"Herausgegeben von August Hagen. "; Publisher's advertisement: [1] p. at end (Bd. 1) Book.
1829 - Gale Group | NCCO Corvey
Johannes Novak, Stefan Novak, Christina Bitsch, Chlodwig Franz,
... Share a linkShare onEmailFacebookTwitterLinkedInRedditWechat Abstract Valeriana celtica ssp. norica was collected until 70 years ago in huge ... of two different populations of Valeriana celtica ssp. norica from Gleinalm and Schoberriegel (Austria) and one population ... two different subspecies; the two Valeriana celtica ssp. norica populations also showed significantly different compositions. Further research ... der Nutzung einer naturgeschützten Pflanze (Valeriana celtica ssp. norica) auf ihren Bestand, Nationalparkverwaltung Nockberge, Sauereggen, Klagenfurt, Wien ( ...
Tópico(s): Plant and animal studies
2000 - Wiley | Flavour and Fragrance Journal
Joseph Mazzini, D. Bratiano, S. W. Hill, Thomas Noel, Henry Travis,
... The Arts The History of Pantomimes, Gift Books Norica; or, Tales of Nürnberg from the Olden Time. ...
1851 - Gale Group | NCCO BritishPolitics
Johannes Novak, Chlodwig Franz, Stefan Novak,
Abstract Dried plants of Valeriana celtica L. ssp. norica Vierh. collected in Austria have been divided in ... 220. The Austrian oil of V. celtica ssp. norica differs compared to Italian leaf oil of V. ...
Tópico(s): Plant and Fungal Species Descriptions
1998 - Taylor & Francis | Journal of Essential Oil Research
... Pekin, &c. By The Late Rev. Charles Gutzlapf Norica; Or, Tales Of Nurnberg. From The Olden Time. ...
1852 - Gale Group | The Economist
Martin Čertner, Filip Kolář, Božo Frajman, Manuela Winkler, Peter Schönswetter,
... disentangle origin and evolutionary history of tetraploid Knautia norica, endemic to the eastern Central Alps in Austria. ... contributed to the greater evolutionary success of K. norica, compared with its stenoendemic progenitor K. carinthiaca. There ... introgression of morphologically divergent K. drymeia into K. norica, which might present a threat to the long- ...
Tópico(s): Genetic diversity and population structure
2019 - Elsevier BV | Perspectives in Plant Ecology Evolution and Systematics
Palmira Ros-Farré, Juli Pujade‐Villar,
... cavroi (Hedicke, 1914), O. latreillii (Hartig, 1840), O. norica Giraud, 1860 and O. orientalis Belizin, 1968 are ... O. abnormis (Kieffer, 1901) are synonymized with O. norica, and O. ruficornis Thomson, 1877 is synonymized with ...
Tópico(s): Insect-Plant Interactions and Control
2011 - Q15088586 | Zootaxa
Ştefana M. Petrescu, Norica Branza‐Nichita, Gabriela Negroiu, Andrei‐José Petrescu, Raymond A. Dwek,
... of Chaperones That Recognize Glycans†Stefana M. Petrescu, Norica Branza-Nichita, Gabriela Negroiu, Andrei J. Petrescu, and ...
Tópico(s): RNA and protein synthesis mechanisms
2000 - American Chemical Society | Biochemistry
Baba Senowbari‐Daryan, R. Pamela Reid,
... rigbyi, and the species Polytholosia ramosa and Polycystocoelia norica are described for the first time. Some of ...
Tópico(s): Crustacean biology and ecology
1987 - NRC Research Press | Canadian Journal of Earth Sciences
Alina Macovei, Cristina Radulescu, Catalin Lazar, Ştefana M. Petrescu, David Durantel, Raymond A. Dwek, Nicole Zitzmann, Norica Nichita,
ABSTRACT Investigation of the entry pathways of hepatitis B virus (HBV), a member of the family Hepadnaviridae , has been hampered by the lack of versatile in vitro infectivity models. Most concepts of hepadnaviral infection come from the more robust duck HBV system; however, whether the two viruses use the same mechanisms to invade target cells is still a matter of controversy. In this study, we investigate the role of an important plasma membrane component, caveolin-1 (Cav-1), in HBV infection. Caveolins ...
Tópico(s): Blood groups and transfusion
2009 - American Society for Microbiology | Journal of Virology
Baba Senowbari‐Daryan, George D. Stanley,
... new species, Polycystocoelia silberlingi n. sp. and Neoguadalupia? norica n. sp., are added to our knowledge of ...
Tópico(s): Plant and Fungal Species Descriptions
1992 - Cambridge University Press | Journal of Paleontology
Norica Branza‐Nichita, Catalin Lazar, David Durantel, Raymond A. Dwek, Nicole Zitzmann,
Bovine viral diarrhea virus (BVDV) is a pestivirus member of the Flaviviridae family, closely related to, and used as a surrogate model for the hepatitis C virus. Its envelope contains the E1 and E2 glycoproteins, disulfide linked into homo- and heterodimers. In this study, we investigate the role of disulfide bond formation in the folding, assembly, and stability of BVDV glycoproteins. We provide molecular evidence that intact disulfide bonds are critical for the acquirement of a stable conformation ...
Tópico(s): Plant Virus Research Studies
2002 - Elsevier BV | Biochemical and Biophysical Research Communications
Gertrude‐E. Costin, Mihaela Trif, Norica Nichita, Raymond A. Dwek, Ştefana M. Petrescu,
Tyrosinase, the key enzyme of melanin biosynthesis, is inactivated in melanoma cells following the incubation with the imino-sugar N-butyldeoxynojirimycin, an inhibitor of the endoplasmic reticulum N-glycosylation processing. We have previously shown that tyrosinase inhibition requires high NB-DNJ concentrations, suggesting an inefficient cellular uptake of the drug. Here we show that the use of pH-sensitive liposomes composed of dioleoylphosphatidylethanolamine and cholesteryl hemisuccinate for ...
Tópico(s): RNA Interference and Gene Delivery
2002 - Elsevier BV | Biochemical and Biophysical Research Communications
Catalin Lazar, Nicole Zitzmann, Raymond A. Dwek, Norica Branza‐Nichita,
Erns is a pestivirus envelope glycoprotein indispensable for virus attachment and infection of target cells. Unlike the other two envelope proteins E1 and E2, Erns lacks a transmembrane domain and a vast quantity is secreted into the medium of infected cells. The protein is also present in fractions of pure pestivirus virions, raising the important and intriguing question regarding the mechanism of its attachment to the pestivirus envelope. In this study a direct interaction between Erns and E2 ...
Tópico(s): Viral gastroenteritis research and epidemiology
2003 - Elsevier BV | Virology
U. Kağan Tekın, Tuğrul Şükrü Yurtsever,
... Three species (Nodocapnuchosphaera altineri, Renzium whalenae and Enoplocampe(?) norica) and one subspecies (Kinyrosphaera helicata goekcamensis) are defined ...
Tópico(s): Geological and Geophysical Studies
2003 - Copernicus Publications | Journal of Micropalaeontology
Stephen D. Woodhouse, Caroline Smith, Maud Michelet, Norica Branza‐Nichita, Mark S. Hussey, Raymond A. Dwek, Nicole Zitzmann,
ABSTRACT We evaluated interferon (IFN) and ribavirin (RBV) as dual therapy and as part of triple-combination therapies with the iminosugars N -butyl-deoxynojirimycin ( N B-DNJ), N -nonyl-deoxynojirimycin, and N -7-oxanonyl-6-deoxymethyl-galactonojirimycin. The ability of these compounds to clear bovine viral diarrhea virus (BVDV), a surrogate model for hepatitis C virus (HCV), from a persistently infected Madin-Darby bovine kidney cells cell line was determined by monitoring the secretion of viral RNA and ...
Tópico(s): Virus-based gene therapy research
2008 - American Society for Microbiology | Antimicrobial Agents and Chemotherapy
... laxa (2n ≈ 4x), F. lemanii (2n ≈ 6x), F. norica (2n ≈ 2x), F. ovina subsp. ovina (2n ≈ 2x), ...
Tópico(s): Plant and fungal interactions
2008 - Springer Nature | Biologia
Stephanie Pollock, Norica Nichita, Annette Isabel Böhmer, Cristina Radulescu, Raymond A. Dwek, Nicole Zitzmann,
The pressing need for broad-spectrum antivirals could be met by targeting host rather than viral processes. Cholesterol biosynthesis within the infected cell is one promising target for a large number of viral systems, including hepatitis C virus (HCV), hepatitis B virus (HBV) and HIV. Liposomes developed for intracellular, endoplasmic reticulum (ER)-targeted in vivo drug delivery have been modified to include polyunsaturated fatty acids that exert an independent antiviral activity through the reduction ...
Tópico(s): HIV/AIDS drug development and treatment
2010 - National Academy of Sciences | Proceedings of the National Academy of Sciences
Norica Godja, Nóra Zsuzsa Kiss, Ch. Löcker, Andreas Schindel, Aleksandra Gavrilović-Wohlmuther, J. Wosik, R. F. Mann, J. Wendrinsky, A. Merstallinger, Gerhard Nauer,
Aerospace applications and energy saving strategies in general boosted the interest and the research in the field of light weight materials, typically on alloys based on aluminium. Aluminium itself does not provide sufficient mechanical strength for structural parts, but there exists a lot of recently developed alloys containing silicon, copper, magnesium, zinc or manganese in various combinations and compositions exhibiting excellent mechanical properties. These alloys require surface treatments ...
Tópico(s): Corrosion Behavior and Inhibition
2010 - Elsevier BV | Tribology International
Stephanie Pollock, Robin Antrobus, Laura Newton, Bettina Kampa, Jan Rossa, Sally Latham, Norica Nichita, Raymond A. Dwek, Nicole Zitzmann,
Liposomes are vesicular structures consisting of an aqueous core surrounded by a lipid bilayer. Apart from the cytosol and lysosomes, no other intracellular compartment has been successfully targeted using liposomal delivery. Here, we report the development of liposomes capable of specific targeting to the endoplasmic reticulum (ER) and associated membranes. Using competition and inhibitor assays along with confocal microscopy, we have determined that ER liposomes utilize scavenger and low-density ...
Tópico(s): Pancreatic function and diabetes
2010 - Wiley | The FASEB Journal
Catalin Lazar, David Durantel, Alina Macovei, Nicole Zitzmann, Fabien Zoulim, Raymond A. Dwek, Norica Branza‐Nichita,
Trimming of the N-glycans attached to the envelope proteins of hepatitis B virus (HBV) is required in different steps of the viral life cycle. Inhibition of the host enzymes α-glucosidases, involved in the endoplasmic reticulum (ER)-associated processing of the N-linked glycans, results in misfolding of the HBV envelope proteins, prevention of HBV secretion and accumulation of viral DNA within infected cells. However, the impact of these effects on HBV morphogenesis and infectivity of the viral particles ...
Tópico(s): Viral gastroenteritis research and epidemiology
2007 - Elsevier BV | Antiviral Research
Cristina M. Dorobantu, Alina Macovei, Catalin Lazar, Raymond A. Dwek, Nicole Zitzmann, Norica Branza‐Nichita,
ABSTRACT Previous reports have shown that cholesterol depletion of the membrane envelope of the hepatitis B virus (HBV) impairs viral infection of target cells. A potential function of this lipid in later steps of the viral life cycle remained controversial, with secretion of virions and subviral particles (SVP) being either inhibited or not affected, depending on the experimental approach employed to decrease the intracellular cholesterol level. This work addressed the role of host cell cholesterol ...
Tópico(s): Endoplasmic Reticulum Stress and Disease
2011 - American Society for Microbiology | Journal of Virology
... previously identified species; and 4) upper Norian Otaparia norica n. sp. which has a delicate thin shell, ...
Tópico(s): Aquatic Invertebrate Ecology and Behavior
2011 - Cambridge University Press | Journal of Paleontology
Alina Macovei, Nicole Zitzmann, Catalin Lazar, Raymond A. Dwek, Norica Branza‐Nichita,
The enveloped bovine viral diarrhea virus (BVDV) is a member of the Pestivirus genus within the Flaviviridae family. While considerable information has been gathered on virus entry into the host cell, genome structure and protein function, little is known about pestivirus morphogenesis and release from cells. Here, we analyzed the intracellular localization, N-glycan processing and secretion of BVDV using brefeldin A (BFA), which blocks protein export from the endoplasmic reticulum (ER) and causes ...
Tópico(s): Viral Infections and Vectors
2006 - Elsevier BV | Biochemical and Biophysical Research Communications
Robert M. Moriarty, Carmen Irena Mitan, Norica Branza‐Nichita, Kenneth R. Phares, Damon A. Parrish,
A facile synthesis is reported for five-membered iminocyclitols which allows for variation in stereochemistry at all the chiral centers, diverse C1- and N-substitution, and the potential for a three-component combinatorial process. The key step is inversion at the C4 stereocenter (l-lyxo sugar → d-ribono azasugar). The exo-imino to endo-iminocyclitol process was extended to the d-lyxo and the d- and l-hexose series. Some analogues were found to be more potent than N-butyl DNJ and N-nonyl DNJ in antiviral ...
Tópico(s): HIV/AIDS drug development and treatment
2006 - American Chemical Society | Organic Letters
Izabela Sokolowska, Cristina M. Dorobantu, Alisa G. Woods, Alina Macovei, Norica Branza‐Nichita, Costel C. Darie,
Liver infection with hepatitis B virus (HBV), a DNA virus of the Hepadnaviridae family, leads to severe disease, such as fibrosis, cirrhosis and hepatocellular carcinoma. The early steps of the viral life cycle are largely obscure and the host cell plasma membrane receptors are not known. HepaRG is the only proliferating cell line supporting HBV infection in vitro, following specific differentiation, allowing for investigation of new host host-cell factors involved in viral entry, within a more robust ...
Tópico(s): Liver Disease Diagnosis and Treatment
2012 - BioMed Central | Proteome Science
Eugene J. Fine, C. J. Segal-Isaacson, Richard D. Feinman, Silvia Herszkopf, Maria Concetta Romano, Norica Tomuta, Amanda Bontempo, Abdissa Negassa, Joseph A. Sparano,
Most aggressive cancers demonstrate a positive positron emission tomographic (PET) result using ¹⁸F-2-fluoro-2-deoxyglucose (FDG), reflecting a glycolytic phenotype. Inhibiting insulin secretion provides a method, consistent with published mechanisms, for limiting cancer growth.Eligible patients with advanced incurable cancers had a positive PET result, an Eastern Cooperative Oncology Group performance status of 0 to 2, normal organ function without diabetes or recent weight loss, and a body mass ...
Tópico(s): Cancer, Hypoxia, and Metabolism
2012 - Elsevier BV | Nutrition
Paula Florian, Alina Macovei, Livia Elena Sima, Norica Nichita, Inger Mattsby‐Baltzer, Anca Roșeanu,
Different cell types have been reported to internalize lactoferrin (Lf) by specific or nonspecific receptors. Our studies focused on the endocytic pathway of human Lf in macrophage-like THP-1 cells. Lactoferrin was found to be internalized by THP-1 cells differentiated with phorbol myristate acetate. Incubation of cells with chlorpromazine and dansylcadaverine, inhibitors of clathrin-dependent endocytosis, led to a 50% inhibition of Lf internalization compared with untreated cells. Bafilomycin A1 ...
Tópico(s): Neonatal Health and Biochemistry
2012 - NRC Research Press | Biochemistry and Cell Biology
Catalin Lazar, Alina Macovei, Ştefana M. Petrescu, Norica Branza‐Nichita,
Hepatitis B virus (HBV) belongs to the Hepadnaviridae family of enveloped DNA viruses. It was previously shown that HBV can induce endoplasmic reticulum (ER) stress and activate the IRE1-XBP1 pathway of the unfolded protein response (UPR), through the expression of the viral regulatory protein X (HBx). However, it remained obscure whether or not this activation had any functional consequences on the target genes of the UPR pathway. Of these targets, the ER degradation-enhancing, mannosidase-like proteins ( ...
Tópico(s): Hepatitis B Virus Studies
2012 - Public Library of Science | PLoS ONE
Davor Pavlović, Wolfgang B. Fischer, M. Hussey, David Durantel, S. Durantel, Norica Branza‐Nichita, S. Woodhouse, Raymond A. Dwek, Nicole Zitzmann,
Tópico(s): Animal Virus Infections Studies
2005 - Springer Nature | Advances in experimental medicine and biology