Julia Catalán, Ghita C.‐M. Falck, Hannu Norppa,
... Wessman M Lindholm C Knuutila S Sorsa M Norppa H Age-associated micronuclei containing centromeres and the ... al. Surrallés et al., 1996aSurrallés J Falck G Norppa H In vivo cytogenetic damage revealed by FISH ... et al., 1998Catalán J Autio K Kuosma E Norppa H Age-dependent inclusion of sex chromosomes in ... use of cytochalasin B for 72 hours (see Norppa et al. Norppa et al., 1993Norppa H Renzi L Lindholm C ... Lindholm et al. Lindholm et al., 1991Lindholm C Norppa H Hayashi M Sorsa M Induction of micronuclei ...
Tópico(s): Genomic variations and chromosomal abnormalities
2000 - Elsevier BV | The American Journal of Human Genetics
Hannu Norppa, Merja Penttilä, Marja Sorsa, Eeva‐Liisa Hintikka, Taina Ilus,
... chromosome changes in Chinese hamster bone marrow HANNU NORPPA, HANNU NORPPA Institute of Occupational Health, Helsinki, FinlandSearch for more ... FinlandSearch for more papers by this author HANNU NORPPA, HANNU NORPPA Institute of Occupational Health, Helsinki, FinlandSearch for more ...
Tópico(s): Plant and fungal interactions
2009 - BioMed Central | Hereditas
Hannu Norppa, Jorma Mäki‐Paakkanen, Kaarina Jantunen, P. Einistö, Riitta Räty,
... Mutagenicity Studies on Styrene and Vinyl Acetatea HANNU NORPPA, HANNU NORPPA Department of Industrial Hygiene and Toxicology Institute of ... FinlandSearch for more papers by this author HANNU NORPPA, HANNU NORPPA Department of Industrial Hygiene and Toxicology Institute of ...
Tópico(s): Pesticide Exposure and Toxicity
1988 - Wiley | Annals of the New York Academy of Sciences
Jordi Surrallés, Julia Catalán, A. Creus, Hannu Norppa, N. Xamena, Ricard Marcos,
... author on: Oxford Academic PubMed Google Scholar H. Norppa, H. Norppa 2Department of Industrial Hygiene and Toxicology, Finnish Institute ...
Tópico(s): DNA and Nucleic Acid Chemistry
1995 - Oxford University Press | Mutagenesis
Mart Uusküla, Hilkka Järventaus, Ari Hirvonen, Marja Sorsa, Hannu Norppa,
... author on: Oxford Academic PubMed Google Scholar Hannu Norppa Hannu Norppa 2 2To whom correspondence should be addressed Search ...
Tópico(s): Estrogen and related hormone effects
1995 - Oxford University Press | Carcinogenesis
Hannu Norppa, L. Renzi, Carita Lindholm,
... staining and in situ hybridization Get access H. Norppa, H. Norppa 1Department of Industrial Hygiene and Toxicology, Institute of ...
Tópico(s): Plant Genetic and Mutation Studies
1993 - Oxford University Press | Mutagenesis
Makoto Hayashi, Hannu Norppa, Toshio Sofuni, Motoi Ishidate,
... author on: Oxford Academic PubMed Google Scholar Hannu Norppa, Hannu Norppa 1Department of Industrial Hygiene and Toxicology, Institute of ...
Tópico(s): Gene expression and cancer classification
1992 - Oxford University Press | Mutagenesis
Hannu Norppa, Harri Vainio, Marja Sorsa,
... in lymphocytes of workers exposed to styrene Hannu Norppa PhD, Corresponding Author Institute of Occupational Health, Helsinki, ... FinlandSearch for more papers by this author Hannu Norppa PhD, Corresponding Author Institute of Occupational Health, Helsinki, ...
Tópico(s): Genetically Modified Organisms Research
1981 - Wiley | American Journal of Industrial Medicine
... Hagmar L, Hemminki K, Merlo F, Natarajan AT, Norppa H, Shuker DE, Tice R, Waters MD, Aitio ... bgp268 CASPubMedWeb of Science®Google Scholar Bonassi S, Norppa H, Ceppi M, Stromberg U, Vermeulen R, Znaor ...
Tópico(s): Immunotherapy and Immune Responses
2014 - Wiley | Genes Chromosomes and Cancer
Pavel Vodička, Alessio Naccarati, Ľudmila Vodičková, Veronika Poláková, Mária Dušinská, Ľudovít Mušák, Erika Halašová, Simona Šůsová, Pavel Souček, Kari Hemminki,
... rectal and lung cancers (Boffetta et al. 2007; Norppa et al. 2006). Nevertheless, these studies, as well ... pathological characteristics.ReferencesBoffetta P, van der Hel O, Norppa H, Fabianova E, Fucic A, Gundy Set al.. ...
Tópico(s): DNA Repair Mechanisms
2009 - National Institute of Environmental Health Sciences | Environmental Health Perspectives
Mark P. Little, Richard Wakeford, E. Janet Tawn, Simon Bouffler, Amy Berrington de González,
... 2005;45:258–270. Crossref, Medline, Google Scholar54 Norppa H, Bonassi S, Hansteen IL, et al. Chromosomal ... Google Scholar55 Boffetta P, van der Hel O, Norppa H, et al. Chromosomal aberrations and cancer risk: ...
Tópico(s): Radioactivity and Radon Measurements
2009 - Radiological Society of North America | Radiology
Anton Brögger, R A Norum, Inger‐Lise Hansteen, Kjell Oskar Clausen, KIRSTI SKÅRDAL, Felix Mitelman, Anne-Marie Kolnig, Bodil Strömbeck, Ingrid Nordenson, Gunilla Andersson, Krister Jakobsson, Jorma Mäki‐Paakkanen, Hannu Norppa, Hilkka Järventaus, Marja Sorsa,
... Nordenson, I., Andersson, G., Jakobsson, K., Mäkipaaskkanen, J., Norppa, H., Järventaus, H. and Sorsa, M. 1984. Comparison ...
Tópico(s): Acute Lymphoblastic Leukemia research
2008 - BioMed Central | Hereditas
Hitoshi Ishikawa, Ying Tian, Toru Yamauchi,
... abstract is available for this article. References 1H Norppa: Cytogenetic markers of susceptibility: influence of polymorphic carcinogen- ... J Sports Med 19, 581– 585 (1998) 7H Norppa, S Luomahaara, H Heikanen, S Roth, M Sorsa, ...
Tópico(s): Air Quality and Health Impacts
2003 - Wiley | Journal of Occupational Health
... 1032– 1037, 1983. 44 Vainio H, Waters MD, Norppa H: Mutagenicity of selected organic solvents. Scand J ... Cold Spring Harbor Laboratory, 1982. 46 Walles SAS, Norppa H, Osterman-Golkar S, Mäki-Paakkanen J: Single- ...
Tópico(s): Carcinogens and Genotoxicity Assessment
1990 - Wiley | CA A Cancer Journal for Clinicians
Gabriel Ángel Martos‐Moreno, Lourdes Travieso‐Suárez, Jesús Pozo‐Román, M.T. Muñoz-Calvo, Julie A. Chowen, Mikko J. Frilander, Luis A. Pérez‐Jurado, Federico Hawkins, Jesús Argente,
... of U12-type introns (Argente et al, 2014; Norppa et al, 2018). We describe the effects of ... Paediatr 89: 200–204CrossrefCASPubMedWeb of Science®Google Scholar Norppa AJ, Kauppala TM, Heikkinen HA, Verma B, Iwai ... of Science®Google Scholar Verma B, Akinyi MV, Norppa AJ, Frilander MJ (2018) Minor spliceosome and disease. ...
Tópico(s): Adipose Tissue and Metabolism
2018 - Springer Nature | EMBO Molecular Medicine
Ekaterina Nepovinnykh, Tuomas Eerola, Vincent Biard, Piia Mutka, Marja Niemi, Mervi Kunnasranta, Heikki Kälviäinen,
... the results for two baseline methods-HotSpotter and NORPPA-are provided. The SealID dataset has been made ...
Tópico(s): Marine animal studies overview
2022 - Multidisciplinary Digital Publishing Institute | Sensors
Ana Tavares, Kukka Aimonen, Sophie Ndaw, Aleksandra Fučić, Julia Catalán, Radu Corneliu Duca, Lode Godderis, Bruno Costa Gomes, Beata Janasik, Carina Ladeira, Henriqueta Louro, Sónia Namorado, An Van Nieuwenhuyse, Hannu Norppa, Paul T.J. Scheepers, Célia Ventura, Jelle Verdonck, Susana Viegas, Wojciech Wąsowicz, Tiina Santonen, Maria João Silva,
A study was conducted within the European Human Biomonitoring Initiative (HBM4EU) to characterize occupational exposure to Cr(VI). Herein we present the results of biomarkers of genotoxicity and oxidative stress, including micronucleus analysis in lymphocytes and reticulocytes, the comet assay in whole blood, and malondialdehyde and 8-oxo-2′-deoxyguanosine in urine. Workers from several Cr(VI)-related industrial activities and controls from industrial (within company) and non-industrial (outwith company) ...
Tópico(s): Effects and risks of endocrine disrupting chemicals
2022 - Multidisciplinary Digital Publishing Institute | Toxics
Kukka Aimonen, Monireh Imani, Mira Hartikainen, Satu Suhonen, Esa Vanhala, C. Moreno, Orlando J. Rojas, Hannu Norppa, Julia Catalán,
Cellulose nanofibrils (CNFs) have emerged as a sustainable and environmentally friendly option for a broad range of applications. The fibrous nature and high biopersistence of CNFs call for a thorough toxicity assessment, but it is presently unclear which physico-chemical properties could play a role in determining the potential toxic response to CNF. Here, we assessed whether surface composition and size could modulate the genotoxicity of CNFs in human bronchial epithelial BEAS-2B cells. We examined ...
Tópico(s): Electrospun Nanofibers in Biomedical Applications
2022 - BioMed Central | Particle and Fibre Toxicology
Vittorio Fortino, Pia Kinaret, Michele Fratello, Angela Serra, Laura Aliisa Saarimäki, Audrey Gallud, Govind Gupta, Gerard Vales, Manuel Correia, Omid Rasool, Jimmy Ytterberg, Marco P. Monopoli, Tiina Skoog, Peter Ritchie, Sergio Moya, Socorro Vázquez‐Campos, Richard D. Handy, Roland Grafström, Lang Tran, Roman A. Zubarev, Riitta Lahesmaa, Kenneth A. Dawson, Katrin Loeschner, Erik Husfeldt Larsen, Fritz Krombach, Hannu Norppa, Juha Kere, Kai Savolainen, Harri Alenius, Bengt Fadeel, Dario Greco,
Abstract There is an urgent need to apply effective, data-driven approaches to reliably predict engineered nanomaterial (ENM) toxicity. Here we introduce a predictive computational framework based on the molecular and phenotypic effects of a large panel of ENMs across multiple in vitro and in vivo models. Our methodology allows for the grouping of ENMs based on multi-omics approaches combined with robust toxicity tests. Importantly, we identify mRNA-based toxicity markers and extensively replicate ...
Tópico(s): Molecular Biology Techniques and Applications
2022 - Nature Portfolio | Nature Communications
Kukka Aimonen, Satu Suhonen, Mira Hartikainen, Viviana R. Lopes, Hannu Norppa, Natália Ferraz, Julia Catalán,
Wood-derived nanofibrillated cellulose (NFC) has emerged as a sustainable material with a wide range of applications and increasing presence in the market. Surface charges are introduced during the preparation of NFC to facilitate the defibrillation process, which may also alter the toxicological properties of NFC. In the present study, we examined the in vitro toxicity of NFCs with five surface chemistries: nonfunctionalized, carboxymethylated, phosphorylated, sulfoethylated, and hydroxypropyltrimethylammonium- ...
Tópico(s): Nanocomposite Films for Food Packaging
2021 - Multidisciplinary Digital Publishing Institute | Nanomaterials
Pia Kinaret, Joseph Ndika, Marit Ilves, Henrik Wolff, Gerard Vales, Hannu Norppa, Kai Savolainen, Tiina Skoog, Juha Kere, Sergio Moya, Richard D. Handy, Piia Karisola, Bengt Fadeel, Dario Greco, Harri Alenius,
Toxicogenomics opens novel opportunities for hazard assessment by utilizing computational methods to map molecular events and biological processes. In this study, the transcriptomic and immunopathological changes associated with airway exposure to a total of 28 engineered nanomaterials (ENM) are investigated. The ENM are selected to have different core (Ag, Au, TiO
Tópico(s): Air Quality and Health Impacts
2021 - Wiley | Advanced Science
Gerard Vales, Satu Suhonen, Kirsi Siivola, Kai Savolainen, Julia Catalán, Hannu Norppa,
Several studies suggested that gold nanoparticles (NPs) could be genotoxic in vitro and in vivo. However, gold NPs have currently produced present a wide range of sizes and functionalization, which could affect their interactions with the environment or with biological structures and, thus, modify their toxic effects. In this study, we investigated the role of surface charge in determining the genotoxic potential of gold NPs, as measured by the induction of DNA damage (comet assay) and chromosomal ...
Tópico(s): Nanoparticle-Based Drug Delivery
2020 - Multidisciplinary Digital Publishing Institute | Nanomaterials
Kirsi Siivola, Satu Suhonen, Mira Hartikainen, Julia Catalán, Hannu Norppa,
We studied the genotoxicity and cellular uptake of nanosized (<50 nm) and fine (<10 μm) copper oxide (CuO) particles in vitro in human bronchial epithelial (BEAS-2B) cells. In addition, the effect of dispersing the particles using bovine serum albumin (BSA) on DNA damage induction was investigated. DNA damage was assessed by the alkaline comet (single cell gel electrophoresis) assay after 3-h, 6-h and 24-h exposures. The cytokinesis-block micronucleus assay was applied to study chromosome damage. Both fine- ...
Tópico(s): Heavy Metal Exposure and Toxicity
2020 - Elsevier BV | Mutation Research/Genetic Toxicology and Environmental Mutagenesis
Niels Hadrup, Kukka Aimonen, Marit Ilves, Hanna Lindberg, Rambabu Atluri, Nicklas Sahlgren, Nicklas Raun Jacobsen, Kenneth Klingenberg Barfod, Trine Berthing, Alan Lawlor, Hannu Norppa, Henrik Wolff, Keld Alstrup Jensen, Karin Sørig Hougaard, Harri Alenius, Julia Catalán, Ulla Vogel,
Materials can be modified for improved functionality. Our aim was to test whether pulmonary toxicity of silica nanomaterials is increased by the introduction of: a) porosity; and b) surface doping with CuO; and whether c) these modifications act synergistically. Mice were exposed by intratracheal instillation and for some doses also oropharyngeal aspiration to: 1) solid silica 100 nm; 2) porous silica 100 nm; 3) porous silica 100 nm with CuO doping; 4) solid silica 300 nm; 5) porous silica 300 nm; ...
Tópico(s): Ga2O3 and related materials
2020 - Taylor & Francis | Nanotoxicology
Niels Hadrup, Kristina Bram Knudsen, Trine Berthing, Henrik Wolff, Stefan Bengtson, Christian Kofoed, Roall Espersen, Casper Højgaard, Jakob R. Winther, Martin Willemoës, Irene Wedin, Markus Nuopponen, Harri Alenius, Hannu Norppa, Håkan Wallin, Ulla Vogel,
We studied if the pulmonary and systemic toxicity of nanofibrillated celluloses can be reduced by carboxylation. Nanofibrillated celluloses administered at 6 or 18 μg to mice by intratracheal instillation were: 1) FINE NFC, 2–20 μm in length, 2–15 nm in width, 2) AS (−COOH), carboxylated, 0.5–10 μm in length, 4–10 nm in width, containing the biocide BIM MC4901 and 3) BIOCID FINE NFC: as (1) but containing BIM MC4901. FINE NFC administration increased neutrophil influx in BAL and induced SAA3 in plasma. ...
Tópico(s): Nanoparticles: synthesis and applications
2019 - Elsevier BV | Environmental Toxicology and Pharmacology
Marit Ilves, Sara Vilske, Kukka Aimonen, Hanna Lindberg, Saila K. Pesonen, Irene Wedin, Markus Nuopponen, Esa Vanhala, Casper Højgaard, Jakob R. Winther, Martin Willemoës, Ulla Vogel, Henrik Wolff, Hannu Norppa, Kai Savolainen, Harri Alenius,
Nanofibrillated cellulose (NFC) is a renewable nanomaterial that has beneficial uses in various applications such as packaging materials and paper. Like carbon nanotubes (CNT), NFCs have high aspect ratio and favorable mechanical properties. The aspect ratio also rises a concern whether NFC could pose a health risk and induce pathologies, similar to those triggered by multi-walled CNT. In this study, we explored the immunomodulatory properties of four NFCs in vitro and in vivo, and compared the results ...
Tópico(s): Nanocomposite Films for Food Packaging
2018 - Taylor & Francis | Nanotoxicology
Bhupendra Verma, Maureen V. Akinyi, Antto J. Norppa, Mikko J. Frilander,
The U12-dependent (minor) spliceosome excises a rare group of introns that are characterized by a highly conserved 5' splice site and branch point sequence. Several new congenital or somatic diseases have recently been associated with mutations in components of the minor spliceosome. A common theme in these diseases is the detection of elevated levels of transcripts containing U12-type introns, of which a subset is associated with other splicing defects. Here we review the present understanding of ...
Tópico(s): RNA Interference and Gene Delivery
2017 - Elsevier BV | Seminars in Cell and Developmental Biology
Moving towards a bio-based and circular economy implies a major focus on the responsible and sustainable utilization of bio-resources. The emergence of nanotechnology has opened multiple possibilities, not only in the existing industrial sectors, but also for completely novel applications of nanoscale bio-materials, the commercial exploitation of which has only begun during the last few years. Bio-based materials are often assumed not to be toxic. However, this pre-assumption is not necessarily ...
Tópico(s): Nanoparticles: synthesis and applications
2017 - Multidisciplinary Digital Publishing Institute | Bioengineering
Antto J. Norppa, Tuuli M. Kauppala, Harri Heikkinen, Bhupendra Verma, Hideo Iwaï, Mikko J. Frilander,
Mutations in the components of the minor spliceosome underlie several human diseases. A subset of patients with isolated growth hormone deficiency (IGHD) harbors mutations in the RNPC3 gene, which encodes the minor spliceosome-specific U11/U12-65K protein. Although a previous study showed that IGHD patient cells have defects in U12-type intron recognition, the biochemical effects of these mutations on the 65K protein have not been characterized. Here, we show that a proline-to-threonine missense ...
Tópico(s): Cancer-related molecular mechanisms research
2017 - Cold Spring Harbor Laboratory Press | RNA
Julia Catalán, Helene Stockmann‐Juvala, Hannu Norppa,
Several approaches have recently been proposed for predicting the potential hazard and risk to human health of engineered nanomaterials (NMs). Here, we present a theoretical approach to assess the mutagenic potential of NMs, which could be incorporated into risk assessment tools. Following the weight of evidence approach recommended for chemicals, we describe criteria for evaluating and weighting existing literature information, based on current knowledge on the relevance and limitations of genotoxicity ...
Tópico(s): Air Quality and Health Impacts
2017 - Taylor & Francis | Nanotoxicology