Produção Nacional
Revisado por pares
Hugo Alexandre Oliveira Rocha, Fábio A. Moraes, Edvaldo da Silva Trindade, Célia Regina Cavichiolo Franco, Ricardo J.S. Torquato, Sílvio Sanches Veiga, Ana Paula Valente, Paulo A.S. Mourão, Edda Lisboa Leite, Helena B. Nader, Carl P. Dietrich,
... C.F. Armelin H.A. Dietrich C.P. Nader H.B. J. Cell. Biochem. 1998; 70: 563-572Crossref PubMed Scopus (25) Google Scholar).Assay for Factor Xa Activity—Confluent endothelial cells grown in 100-mm ...
Tópico(s): Therapeutic Uses of Natural Elements
2005 - Elsevier BV | Journal of Biological Chemistry
Produção Nacional
Revisado por pares
Samara Evangelista Reis, Rogeria Gabriela C. Andrade, Camila M. Accardo, Lenize F. Maia, Luiz Fernando Cappa de Oliveira, Helena B. Nader, Jair Adriano Kopke de Aguiar, Valquíria P. Medeiros,
The interest in bioactive compounds from natural sources, such as marine organisms, has increased considerably in recent years. Among these compounds, sulfated polysaccharides from seaweed exhibit a broad spectrum of biological activities. Sulfated polysaccharides from green algae are still poorly investigated. For this reason, in this study, using unusual methodologies, such as extraction conditions, FACE, and RAMAN, we investigated the structural features of F50UL and F70UL sulfated polysaccharides ...
Tópico(s): Polysaccharides and Plant Cell Walls
2019 - Elsevier BV | Algal Research
Jack Hirsh, Sonia S. Anand, Jonathan L. Halperin, Valentı́n Fuster,
... M, Sawaya R, Harhous Z, Alefishat E and Nader M (2021) Mechanisms of COVID-19-induced kidney ...
Tópico(s): Proteoglycans and glycosaminoglycans research
2001 - Lippincott Williams & Wilkins | Arteriosclerosis Thrombosis and Vascular Biology
Henry G. Watson, Simon Davidson, David Keeling,
... very common in the 72 h post-surgery (Nader et al, 1999). In these patients platelet recovery ... dermatan sulphate and chondroitin sulphate. It indirectly inhibits Xa and, to a lesser degree, thrombin. It has ... it. If monitoring is required, a specific anti-Xa assay calibrated for danaparoid should be used. The chromogenic anti-Xa assay is not affected by factors that may ... a low dose ('prophylactic') regimen of 750 anti-Xa units b.d. or t.i.d. subcutaneously ... 2003) reported favourable outcomes using 600–800 anti-Xa units b.d. or 10 u/kg b. ...
Tópico(s): Intramuscular injections and effects
2012 - Wiley | British Journal of Haematology
Produção Nacional
Revisado por pares
Adriana S. Brito, Rômulo S. Cavalcante, Lais C. G. F. Palhares, Ashley J. Hughes, Giulianna P.V. Andrade, Edwin A. Yates, Helena B. Nader, Marcelo A. Lima, Suely F. Chavante,
... its significant anticoagulant activity in aPTT and Factor-Xa inhibition assays. Interestingly, in contrast to mammalian heparin, ... they reveal a novel molecule with significant anti-Xa activity coupled with low bleeding effects which make ...
Tópico(s): Protease and Inhibitor Mechanisms
2013 - Elsevier BV | Carbohydrate Polymers
Produção Nacional
Revisado por pares
Suely F. Chavante, Elizeu Antunes dos Santos, Fernanda W. Oliveira, Marco Guerrini, Giangiacomo Torri, Benito Casu, Carl P. Dietrich, Helena B. Nader,
... anticlotting activity in the APTT and anti-factor Xa assays the A. franciscana heparan sulphate has a ...
Tópico(s): Marine Sponges and Natural Products
2000 - Elsevier BV | International Journal of Biological Macromolecules
Produção Nacional
Revisado por pares
Carl P. Dietrich, Jose F. de Paiva, Ricardo A.B. Castro, Suely F. Chavante, Walter Jeske, Jawed Fareed, Philip A.J. Gorin, Aline Mendes, Helena B. Nader,
... is mainly exerted through the inhibition of factor Xa and heparin cofactor II-mediated inhibition of thrombin. ...
Tópico(s): Marine Sponges and Natural Products
1999 - Elsevier BV | Biochimica et Biophysica Acta (BBA) - General Subjects
Produção Nacional
Revisado por pares
Helena B. Nader, Carla Cristina Lopes, Hugo Alexandre Oliveira Rocha, Elizeu Antunes dos Santos, Carl P. Dietrich,
... acids (mollusk heparins) possess high anticloting and anti-Xa activities. These results also suggest that a proper ...
Tópico(s): Fibroblast Growth Factor Research
2004 - Bentham Science Publishers | Current Pharmaceutical Design
Produção Nacional
Revisado por pares
Lais C. G. F. Palhares, Adriana S. Brito, Marcelo A. Lima, Helena B. Nader, James A. London, Igor Barsukov, Giulianna P.V. Andrade, Edwin A. Yates, Suely F. Chavante,
... by activated partial thromboplastin time, anti-IIa, anti-Xa and anti-heparin cofactor II-mediated activities, and ...
Tópico(s): Invertebrate Immune Response Mechanisms
2019 - Elsevier BV | Carbohydrate Polymers
David F. Aberle, Abner Cohen, Aeron Davis, Michael J. Levy, Francis X. Sutton,
... org/10.1111/j.1749-6632.1960.tb39126.xA. J. W. Taylor Psychology and values, Australian Journal ...
Tópico(s): Epistemology, Ethics, and Metaphysics
1950 - University of Chicago Press | Ethics
... 1 McDuffie, N. M., Dietrich, C. P., and Nader, H. B.: Electrofocusing of heparin-fractionation of heparin ... heparin. J. Biol. Chem. 250: 6841 (1975). 4 Nader, H. B., McDuffie, N. M., and Dietrich, C. ... method based upon the potentiation of anti-factor Xa. Thromb. Haemostas. 30: 471 (1973). 65 Yin, E. ...
Tópico(s): Cell Adhesion Molecules Research
1979 - Wiley | The Journal of Clinical Pharmacology
... Paiva JF, Moraes CT, Takahashi HK, Porcionatto MA, Nader HB. Isolation and characterization of a heparin with ... luminogenic peptide substrate, on blood coagulation Factor X/Xa produced by mouse peritoneal macrophages. Biochem J 1982; ...
Tópico(s): Hemostasis and retained surgical items
1987 - Wiley | Acta Medica Scandinavica
Tomio Yabe, Ritsuko Hosoda‐Yabe, Yoshihiro Kanamaru, Makoto Kiso,
... E.L. Andrade G.P. Oliveira F.W. Nader H.B. Chavante S.F. Bioorg. Med. Chem. ...
Tópico(s): Platelet Disorders and Treatments
2011 - Elsevier BV | Journal of Biological Chemistry
Produção Nacional
JoséF. Paiva, Elizeu Antunes dos Santos, Walter Jeske, Jawed Fareed, Helena B. Nader, Carl P. Dietrich,
... intrinsic and extrinsic pathways of thrombin and factor Xa generation. Mollusan heparin has about the same activity ... high affinity-heparin on the inhibition of factor Xa and thrombin in the presence of antithrombin III ...
Tópico(s): Blood Coagulation and Thrombosis Mechanisms
1995 - Elsevier BV | Comparative Biochemistry and Physiology Part A Physiology
Produção Nacional
Revisado por pares
Eduardo Ramaciotti, Marisa Anahí Gómez, Jeanine M. Walenga, Debra Hoppensteadt, G. H. Rao, Helena B. Nader, Walter Jeske, Jawed Fareed,
... in the aPTT, Heptest, TT, and amidolytic anti‐Xa, anti‐IIa assays. HIT antibody prevalence and the ...
Tópico(s): Platelet Disorders and Treatments
2010 - Wiley | The FASEB Journal
Jawed Fareed, Helena B. Nader, Marcelo A. Lima, Debra Hoppensteadt, Jeanine M. Walenga, Walter Jeske, E Santhana Kumar, W Raake, M Bakhos,
... utilizing ACT, aPTT, Heptest, Calcium Thrombin Time, anti‐Xa and anti‐IIa activities, as well as protamine ... in comparison to BH. PH exhibited higher anti‐Xa and anti‐IIa activities. The USP cross referenced potency in the anti‐Xa assay was 160 + 20 U/mg for PH ...
Tópico(s): Proteoglycans and glycosaminoglycans research
2015 - Wiley | The FASEB Journal
Produção Nacional
Revisado por pares
Walter J. Gomes, Domingo Marcolino Braile, João Carlos Ferreira Leal, Solange Guizilini, Marisa M. Regenga, Ahmed Kouta, Jeanine M. Walenga, Walter Jeske, Debra Hoppensteadt, Eduardo Ramacciotti, Helena B. Nader, Marcelo A. Lima, Jawed Fareed,
... global clotting activity (ACT, APTT) and amidolytic anti‐Xa levels. TNFa, IL‐6, and TFPI antigen were ... 2016). Results All coagulation parameters (ACT, APTT, anti‐Xa, residual bleeding) demonstrated comparable heparinization ( p ≥ 0.05). ...
Tópico(s): Atrial Fibrillation Management and Outcomes
2019 - Wiley | The FASEB Journal