Samia Kalsoom, Ammara Zamir, Anees ur Rehman, Waseem Ashraf, Imran Imran, Hamid Saeed, Abdul Majeed, Faleh Alqahtani, Muhammad Fawad Rasool,
Nadolol is a non-selective beta-adrenergic antagonist that is used for the treatment of hypertension and ... of all the available pharmacokinetic (PK) data on nadolol in humans. This review aimed to systematically collate ... analyze publish data on the clinical PK of nadolol in humans and this can be beneficial for ... All the relevant articles containing PK data of nadolol in humans were retrieved. A total of 1275 ... curve (AUC) and maximum plasma concentration (Cmax ) of nadolol increased in a dose-dependent manner. The t½ ...
Tópico(s): Vitamin K Research Studies
2022 - Wiley | Journal of Clinical Pharmacy and Therapeutics
Elena Pope, Irene Lara‐Corrales, Cathryn Sibbald, Carmen Liy‐Wong, Nordau Kanigsberg, Beth A. Drolet, Jin Ma,
... However, other less lipophilic β-blockers, such as nadolol, may be preferable in individuals who experience propranolol ... To document the noninferiority and safety of oral nadolol compared with oral propranolol in infants with IH. ... a noninferiority margin of 10% compared propranolol with nadolol in infants aged 1 to 6 months with ... impairment or cosmetic disfigurement. Interventions Oral propranolol and nadolol in escalating doses up to 2 mg/kg ... were female. Thirty-five infants were treated with nadolol. The mean (SD) age in this group was ...
Tópico(s): Vascular Tumors and Angiosarcomas
2021 - American Medical Association | JAMA Pediatrics
Shingen Misaka, Osamu Abe, Tomoyuki Ono, Yuko Ono, H. Ogata, Itaru Miura, Yayoi Shikama, Martin F. Fromm, Hirooki Yabe, Kenju Shimomura,
... tea (GT), administered concomitantly or 1 hour before nadolol intake on nadolol pharmacokinetics. Methods In a randomized 3‐phase crossover ... 11 healthy volunteers received an oral administration of nadolol with, or 1 hour after preingestion of brewed ... Geometric mean ratio with 90% confidence interval for nadolol AUC 0–48 was 0.371 (0.303– ... In addition, ingestion of GT 1 hour before nadolol administration resulted in a significant reduction of nadolol AUC 0–48 with geometric mean ratio of ... to maximal plasma concentration and renal clearance of nadolol among groups. Conclusion These results suggest that single ...
Tópico(s): Phytochemicals and Antioxidant Activities
2020 - Wiley | British Journal of Clinical Pharmacology
Eric McGillis, Travis Baumann, Jenna M. LeRoy,
Nadolol is a β-adrenergic antagonist that has been shown to be efficacious in the treatment of ... brain barrier. However, the pharmacokinetics and safety of nadolol in infants are not well understood, potentially making ... 10-week-old girl who was started on nadolol for infantile hemangioma, died 7 weeks later, and ... found to have an elevated postmortem cardiac blood nadolol level of 0.94 mg/L. The infant ... before her death, which we hypothesize contributed to nadolol toxicity. Pharmacokinetics studies show a large fraction of ...
Tópico(s): Central Venous Catheters and Hemodialysis
2019 - American Academy of Pediatrics | PEDIATRICS
Shingen Misaka, J. Knop, Katrin Singer, Eva Hoier, Markus Keiser, Fabian Müller, Hartmut Glaeser, Jörg König, Martin F. Fromm,
Nadolol is a nonmetabolized β-adrenoceptor antagonist and is a substrate of OATP1A2, but not of OATP2B1. However, other drug transporters involved in translocation of nadolol have not been characterized in detail. We therefore investigated nadolol as a potential substrate of the hepatic uptake ... the importance of P-glycoprotein (P-gp) for nadolol transport was studied using double transfected MDCK-OCT1-P-gp cells. Nadolol was not transported by OATP1B1 and OATP1B3. In contrast, a significantly higher nadolol accumulation (at 1 and 10 μM) was found ...
Tópico(s): Cannabis and Cannabinoid Research
2015 - American Chemical Society | Molecular Pharmaceutics
José Bernabeu‐Wittel, Basilio Narváez‐Moreno, J.M. de la Torre-García, Israel Fernández‐Pineda, J.J. Domínguez-Cruz, Félix Coserría‐Sánchez, Álvarez-Del-Vayo Concha, Julián Conejo‐Mir,
... to evaluate the efficacy and safety of oral nadolol in a small series of patients whose propranolol ... patients with IHs who were treated with oral nadolol due to propranolol-related sleep disturbances at a ... 2008 and March 2013. Clinical response to oral nadolol and disappearance of propranolol-related side effects were ... discontinued in seven patients and switched to oral nadolol, with resolution of these side effects in 5 ( ... sleep disturbances again after four months of oral nadolol.The sample size was too small to draw ...
Tópico(s): Vascular Malformations Diagnosis and Treatment
2015 - Wiley | Pediatric Dermatology
Shingen Misaka, Junichi Yatabe, Fabian Müller, Kei Takano, Keisuke Kawabe, Hartmut Glaeser, Midori Yatabe, Satomi Onoue, José Pablo Werba, Hiroshi Watanabe, Shizuo Yamada, Martin F. Fromm, Junko Kimura,
... the pharmacokinetics and pharmacodynamics of the β-blocker nadolol. Ten healthy volunteers received a single oral dose of 30 mg nadolol with green tea or water after repeated consumption ... the plasma concentration–time curve (AUC0–48) of nadolol by 85.3% and 85.0%, respectively (P < 0.01), without altering renal clearance of nadolol. The effects of nadolol on systolic blood pressure were significantly reduced by green tea. [3H]-Nadolol uptake assays in human embryonic kidney 293 cells ... anion–transporting polypeptides OATP1A2 and OATP2B1 revealed that nadolol is a substrate of OATP1A2 (Michaelis constant (Km) = ...
Tópico(s): Analytical Chemistry and Chromatography
2014 - Wiley | Clinical Pharmacology & Therapeutics
Shingen Misaka, Nozomu Miyazaki, T Fukushima, Shizuo Yamada, Junko Kimura,
... pharmacokinetics of a non-selective hydrophilic β-blocker nadolol, which is reported to be a substrate for ... a single intragastric administration of 10 mg/kg nadolol. Plasma and urinary concentrations of nadolol were determined using high performance liquid chromatography. Pharmacokinetic ... under the time–plasma concentration curve (AUC) of nadolol by 85% and 74%, respectively, as compared with ... EGCG alone significantly reduced Cmax and AUC of nadolol. Amounts of nadolol excreted into the urine were decreased by pretreatments ...
Tópico(s): Inflammatory mediators and NSAID effects
2013 - Elsevier BV | Phytomedicine
Shingen Misaka, Nozomu Miyazaki, Midori Yatabe, Tomoyuki Ono, Yayoi Shikama, Tetsuhito Fukushima, Junko Kimura,
... of a hydrophilic non‐selective β‐adrenoceptor blocker nadolol, we conducted an open‐label, four‐way crossover ... volunteers. A single oral dose of 30 mg nadolol was administered with water (control), itraconazole (100 mg), ... mg/day). Plasma concentrations and urinary excretions of nadolol were measured over 48 hours after its dosing. ... pressures and pulse rate were periodically recorded after nadolol administration as pharmacodynamic parameters. Itraconazole increased the peak ... the plasma concentration–time curve (AUC 0−∞ ) of nadolol by 468% and 224% of control, respectively ( P < . ...
Tópico(s): Antibiotics Pharmacokinetics and Efficacy
2013 - Wiley | The Journal of Clinical Pharmacology
Gin‐Ho Lo, Wen‐Chi Chen, Huay-Min Wang, Ching-Chang Lee,
Both nadolol and ligation have proved to be effective in the prophylaxis of first variceal bleeding. This study was ... to evaluate the effects and safety of combining nadolol with ligation. Cirrhotic patients with high-risk esophageal ... patients were randomized to receive band ligation plus nadolol (Combined group, 70 patients) or nadolol alone (Nadolol group, 70 patients). In the Combined group multiligators ... an interval of 4 weeks until variceal obliteration. Nadolol was administered at a dose to reduce 25% ...
Tópico(s): Organ Transplantation Techniques and Outcomes
2010 - Lippincott Williams & Wilkins | Hepatology
Càndid Villanueva, Carles Aracil, Alan Colomo, J.M. López-Balaguer, Marta Piqueras, Begoña González, Xavier Torras, Carlos Guarner, J. Balanzó,
... assess the value of HVPG-guided therapy using nadolol + prazosin in nonresponders to nadolol + isosorbide-5-mononitrate (ISMN) compared with a control group treated with nadolol + ligation.Cirrhotic patients with variceal bleeding were randomized to HVPG-guided therapy (n = 30) or nadolol + ligation (n = 29). A Baseline haemodynamic study was ... month. In the guided-therapy group, nonresponders to nadolol + ISMN received nadolol and carefully titrated prazosin and had a third haemodynamic study.Nadolol + prazosin decreased HVPG in nonresponders to nadolol + ISMN ( ...
Tópico(s): Organ Transplantation Techniques and Outcomes
2008 - Wiley | Alimentary Pharmacology & Therapeutics
Guadalupe García–Tsao, Arun J. Sanyal, Norman D. Grace, William D. Carey,
... reasons), switching to a nonselective β-blocker (propranolol, nadolol) would be necessary. A procedure that may replace ... trials evaluating nonselective β-blockers (i.e., propranolol, nadolol) in the prevention of first variceal hemorrhage (primary ... showed that patients with small varices treated with nadolol had a significantly slower progression to large varices ( ... patients evaluating nonselective β-blockers (i.e., propranolol, nadolol) versus non-active treatment or placebo in the ... of prophylactic therapy (55). Nonselective β-blockers (propranolol, nadolol) reduce portal pressure by decreasing cardiac output (β- ...
Tópico(s): Hepatitis C virus research
2007 - Lippincott Williams & Wilkins | The American Journal of Gastroenterology
Guadalupe García–Tsao, Arun J. Sanyal, Norman D. Grace, William D. Carey, Margaret C. Shuhart, Gary L. Davis, Kiran Bambha, Andrés Cárdenas, Stanley M. Cohen, Timothy J. Davern, Steven L. Flamm, Steven Han, Charles D. Howell, David R. Nelson, K. Rajender Reddy, Bruce A. Runyon, John B. Wong, Colina Yim, Nizar N. Zein, John M. Inadomi, Darren Baroni, David Bernstein, William R. Brugge, Lin Chang, William Y. Chey, John A. Cunningham, Kenneth R. DeVault, Steven A. Edmundowicz, Ronnie Fass, Kelvin Hornbuckle, Costas Kefalas, Timothy R. Koch, Jenifer K. Lehrer, Anthony Lembo, John O'Brien, John R. Papp, Henry P. Parkman, Albert C. Roach, Richard E. Sampliner, Amnon Sonnenberg, Subbaramiah Sridhar, Miguel A. Valdovinos, John J. Vargo, Marcelo Vela, Nizar N. Zein,
... reasons, switching to a nonselective β-blocker (propranolol, nadolol) would be necessary. A procedure that may replace ... trials evaluating nonselective β-blockers (i.e., propranolol, nadolol) in the prevention of first variceal hemorrhage (primary ... showed that patients with small varices treated with nadolol had a significantly slower progression to large varices ( ... patients evaluating nonselective β-blockers (i.e., propranolol, nadolol) versus non-active treatment or placebo in the ... of prophylactic therapy.55 Nonselective β-blockers (propranolol, nadolol) reduce portal pressure by decreasing cardiac output (β- ...
Tópico(s): Organ Transplantation Techniques and Outcomes
2007 - Lippincott Williams & Wilkins | Hepatology
Ulrich Thalheimer, Jaime Bosch, Andrew K. Burroughs,
... most commonly used is nonselective β blockers (propranolol, nadolol, or timolol) either as monotherapy or in association ... C. Balanzo J. Novella M.T. et al.Nadolol plus isosorbide mononitrate compared with sclerotherapy for the ... al.Endoscopic ligation compared with combined treatment with nadolol and isosorbide mononitrate to prevent recurrent variceal bleeding. ... C. Balanzo J. Novella M.T. et al.Nadolol plus isosorbide mononitrate compared with sclerotherapy for the ... al.Endoscopic ligation compared with combined treatment with nadolol and isosorbide mononitrate to prevent recurrent variceal bleeding. ...
Tópico(s): Drug-Induced Hepatotoxicity and Protection
2007 - Elsevier BV | Gastroenterology
Seitaro Ohkuma, Masashi Katsura, Masahiro Shibasaki, Atsushi Tsujimura, Masaaki Hirouchi,
... induced by sustained exposure to 10− 8 M nadolol, a non-selective β-AR antagonist, were examined using mouse cerebrocortical neurons. Nadolol dose- and time-dependently increased [3H]CGP-12177 ... cycloheximide (CHX) decreased the bindings with or without nadolol, the extent of increase of the bindings induced by nadolol was not affected by CHX. Actinomycin D (AD) with nadolol showed no affects on the bindings 12 h after nadolol exposure, while AD treated 6 h after nadolol exposure significantly reduced the bindings 48 h after ...
Tópico(s): Neuropeptides and Animal Physiology
2006 - Elsevier BV | Brain Research
José López‐Sendón, Karl Swedberg, John J.V. McMurray, Juan Tamargo, Aldo P. Maggioni, Henry Dargie, Michał Tendera, Finn Waagstein, J Kjekshus, Philippe Lechat, Christian Torp‐Pedersen,
... It has been reported that EGCG reduces plasma nadolol bioavailability in normotensive models. Nevertheless, evidence on the ... i) to investigate the effects of EGCG on nadolol pharmacokinetics (maximum plasma concentration, time to achieve maximum ... identify transcriptional regulatory roles of EGCG on the nadolol intestinal and hepatic drug-transporters in SHR.Male ... days. On day-14, a single dose of nadolol (10 mg/kg body weight) was given to ... measured at 6-h and 22-h post-nadolol administration. Plasma and urinary nadolol concentrations were quantified ...
Tópico(s): Blood Pressure and Hypertension Studies
2005 - Elsevier BV | Revista Española de Cardiología
Gin‐Ho Lo, Wen‐Chi Chen, Mei‐Hsiu Chen, Chi‐Pin Lin, Gin‐Ho Lo, Ping‐I Hsu, Jin‐Shiung Cheng, Kwok‐Hung Lai,
... to band ligation (50 patients) or treatment with nadolol (50 patients). In the ligation group, two to ... weeks until variceal obliteration was achieved. In the nadolol group, the dose of the drug, administered once ... 2.7 (1.1) ligation sessions. In the nadolol group, the mean daily dose of nadolol administered was 60 (20) mg. During follow-up ( ... the ligation group and 16 (32%) in the nadolol group had upper-GI bleeding (p = 0.23). ... the ligation group and 9 (18%) in the nadolol group (p = 0.31). By multivariate Cox analysis, ...
Tópico(s): Gastroesophageal reflux and treatments
2004 - Elsevier BV | Gastrointestinal Endoscopy
Maria Vittoria Pitzalis, Filippo Mastropasqua, Francesco Massari, Andrea Passantino, Paolo Totaro, Cinzia Forleo, P Rizzon,
... years old) were randomized to receive a hydrophilic (nadolol) β-blocker, a lipophilic (metoprolol) β-blocker, and ... the mean (±SD) RR interval (placebo=808±21, nadolol =1,054±30, metoprolol=1,031±27 ms; p<0.0001), RSA (placebo=542, nadolol =1,177, metoprolol=1,316 ms 2 Fouad ... and the gain (placebo=13.6±1.5, nadolol=21.9±2.8, metoprolol=24.5±3. ... the phase function (placebo=–21.1±5.3, nadolol=–1.8±4.9, metoprolol=–2.9±4. ... p<0.0001). No difference was found between nadolol and metoprolol. Conclusions Chronic β-adrenergic blockade enhanced ...
Tópico(s): Cardiac electrophysiology and arrhythmias
1998 - Elsevier BV | CHEST Journal
Carlo Merkel, David Sacerdoti, Massimo Bolognesi, Elena Enzo, Renato Marin, Giancarlo Bombonato, Paolo Angeli, Angelo Gatta,
... before and after 1 month of treatment with nadolol. Nine patients who did not exhibit a decrease ... methodology after 3 months of chronic administration of nadolol + I5M 20 mg twice per day. In poor responders, mean HVPG decrease after nadolol was 8.9% ± 2.8%, and after the ... association. Portal blood flow (PBF) decreased significantly after nadolol (P = .004), and remained unchanged after the addition ... Resistance to portal blood flow (RPBF) increased after nadolol (P = .02) and returned to baseline values during ... combined changes in PBF and in RPBF after nadolol was observed in poor responders, ranging from no ...
Tópico(s): Renal function and acid-base balance
1997 - Lippincott Williams & Wilkins | Hepatology
... before and after 1 month of treatment with nadolol. Nine patients who did not exhibit a decrease ... methodology after 3 months of chronic administration of nadolol + I5M 20 mg twice per day. In poor responders, mean HVPG decrease after nadolol was 8.9% +/- 2.8%, and after the ... association. Portal blood flow (PBF) decreased significantly after nadolol (P = .004), and remained unchanged after the addition ... Resistance to portal blood flow (RPBF) increased after nadolol (P = .02) and returned to baseline values during ... combined changes in PBF and in RPBF after nadolol was observed in poor responders, ranging from no ...
Tópico(s): Eicosanoids and Hypertension Pharmacology
1997 - Lippincott Williams & Wilkins | Hepatology
Carlo Merkel, Renato Marin, Elena Enzo, Carlo Donada, Giorgio Cavallarin, Pierluigi Torboli, Piero Amodio, Giuliana Sebastianelli, David Sacerdoti, Martina Felder, Cesare Mazzaro, Pietro Beltrame, Angelo Gatta,
... mononitrate as an adjunct to the β-blocker nadolol in the prophylaxis of first variceal bleeding in ... study to compare the non-selective β -blocker, nadolol, with nadolol plus isosorbide mononitrate in 146 relatively well (Child- ... oesophageal varices at risk of bleeding. Patients on nadolol alone received a single oral 40 mg daily ... 160 mg daily). Patients receiving both drugs received nadolol as above then isosorbide mononitrate was added starting ... study period 11 of 74 patients from the nadolol alone group and four of 72 from the ...
Tópico(s): Organ Transplantation Techniques and Outcomes
1996 - Elsevier BV | The Lancet
Nuggehally R. Srinivas, William H. Barr, Wen Chyi Shyu, Emmanuel Mohandoss, Shein Chung Chow, Joan E. Staggers, Guhan Balan, Frank J. Belas, Ian A. Blair, Rashmi H. Barbhaiya,
Nadolol, a nonspecific β-blocker, is a racemate composed of equal amounts of four stereoisomers, namely, SQ- ... randomized, four-period crossover study, the pharmacokinetics of nadolol and its stereoisomers and the bioequivalence of two formulations of nadolol were assessed in 20 healthy male subjects following ... compressed tablet formulations, each containing 80 mg of nadolol, with different in vitro dissolution profiles that met ... washout period between successive treatments. All doses of nadolol were administered after an overnight fast. Serial blood ...
Tópico(s): Inflammatory mediators and NSAID effects
1996 - Elsevier BV | Journal of Pharmaceutical Sciences
Nuggehally R. Srinivas, Wen Chyi Shyu, Vinod R. Shah, Dale A. Campbell, Rashmi H. Barbhaiya,
... was developed and validated for the determination of nadolol, a β‐blocker, in human plasma. Nadolol and the internal standard (desmethyl nadolol) were extracted from alkalinized plasma into methyl‐ tert. ‐ ... 4.3 min for the internal standard and nadolol, respectively. The lower limit of quantitation was 5 ... from the nominal values. The extraction recovery of nadolol from human plasma was 64%. Nadolol was stable in human plasma at −20°C ... and for at least three freeze‐thaw cycles. Nadolol and the internal standard were stable in the ...
Tópico(s): Inflammatory mediators and NSAID effects
1995 - Wiley | Biomedical Chromatography
Alfredo H. Jimenez, Geoffrey H. Tofler, Xianghong Chen, Miguel E. Stubbs, Harold S. Solomon, James E. Muller,
... in the morning. We determined the effect of nadolol on the hemodynamic and hemostatic responses to mental ... using a placebo-controlled, double-blind, crossover design. Nadolol reduced systolic pressure and heart rate after mental ... was 139 ± 4 mm Hg during therapy with nadolol versus 161 ± 4 mm Hg during placebo administration ( ... 05). Heart rate increased to 61 ± 2 during nadolol therapy versus 89 ± 5 beats/min during placebo ... systolic pressure increase was similar during therapy with nadolol and placebo (29 ± 2 vs 33 ± 2 beats/ ...
Tópico(s): Sodium Intake and Health
1993 - Elsevier BV | The American Journal of Cardiology
... 5-10 mg once daily was compared with nadolol 40-160 mg once daily in a long- ... 80 patients were randomized to receive amlodipine or nadolol for 26 weeks after a 2-week single- ... run-in period. The effects of amlodipine and nadolol on total exercise time were minimal and not ... increase in time to onset of angina than nadolol (+21% amlodipine; +8% nadolol). No significant differences were noted between amlodipine and nadolol on ST-segment depression, angina attack rate, or ... requirements (as assessed by the rate pressure product). Nadolol produced a reduction of 29% compared with a ...
Tópico(s): Analytical Methods in Pharmaceuticals
1993 - Wiley | Clinical Cardiology
D. Gilligan, Wan Leong Chan, Jo Joshi, Peter Clarke, Astrid Fletcher, Shirley Krikler, Celia M. Oakley,
... Methods. A randomized, double-blind crossover trial of nadolol, verapamil and placebo, administered for periods of 4 ... the study owing to symptomatic sinus bradycardia during nadolol therapy. Neither drug improved maximal oxygen consumption (placebo 26 ± 8, verapamil 23 ± 6, nadolol 21 ± 7 ml/kg per min; p = 0. ... by ≥10 W in 13 patients (81%) during nadolol therapy and in 4 patients (25%) during verapamil therapy (p = 0.005, nadolol vs. verapamil). Despite the effects on exercise capacity, ... patients (81%) preferred drug treatment (8 verapamil, 5 nadolol) over placebo (p = 0.001). Verapamil improved reported ...
Tópico(s): Cardiovascular Conditions and Treatments
1993 - Elsevier BV | Journal of the American College of Cardiology
Ashok V. Mehta, B. Chidambaram,
The efficacy and safety of oral nadolol in supraventricular tachycardia were evaluated prospectively in 27 children (median age 5.5 years). Fifteen patients had an unsuccessful trial of digoxin therapy. Intravenous nadolol was given to seven patients during electrophysiologic study; ... these patients had a similar response to oral nadolol. Twelve patients received both propranolol and nadolol. Among six patients, intravenous propranolol was successful in ... all six had a similar response to oral nadolol. With oral propranolol, tachycardia was well controlled in ...
Tópico(s): Atrial Fibrillation Management and Outcomes
1992 - Elsevier BV | Journal of the American College of Cardiology
Juan Carlos García‐Pagán, Faust Feu, Jaume Bosch, Joan Rodés,
... controlled study on prevention of variceal rebleeding comparing nadolol + ligation vs. hepatic venous pressure gradient-guided pharmacological ... in oesophageal varicesComparison of Endoscopic Variceal Ligation and Nadolol Plus Isosorbide-5-mononitrate in the Prevention of ... Cirrhotic PatientsPharmacologic Therapy of Portal HypertensionComparative study between nadolol and 5-isosorbide mononitrate vs. endoscopic band ligation ... Patients With Variceal HemorrhageIncreased Hepatic ResistanceVariceal ligation plus nadolol compared with ligation for prophylaxis of variceal rebleeding: ...
Tópico(s): Organ Transplantation Techniques and Outcomes
1991 - American College of Physicians | Annals of Internal Medicine
Abraham Sudilovsky, A. Elkind, Ryan Re, JR Saper, Martin Stern, Jarrett Meyer,
... classic and/or common migraine who received either nadolol (80 mg or 160 mg OD) or propranolol ( ... index was found in 48% of patients on nadolol 80 mg (p=NS vs propranolol 160 mg) and in 69% of the patients on nadolol 160 mg compared with 54% on propranolol 160 ... indices was found in 21% of patients on nadolol 80 mg (p=NS vs propranolol 160 mg) and in 41% of patients on 160 mg nadolol as compared to 15% on propranolol 160 mg ( ... from therapy in 2 of 48 patients on nadolol 80 mg (4.1%), 2 of 47 patients on nadolol 160 mg (4.3%), and 4 of 44 ...
Tópico(s): Olfactory and Sensory Function Studies
1987 - Wiley | Headache The Journal of Head and Face Pain
Sanjeev Saksena, George J. Klein, Peter R. Kowey, Ricardo Calvo, R Boccadamo, James E. Brown, Arjun D. Sharma, Arun Gadhoke, Adeoye Y. Olukotun,
... clinical efficacy and safety of intravenous and oral nadolol therapy were examined in 34 patients with recurrent ... control (drug-free) state, after infusion of intravenous nadolol (mean dose 0.09 ± 0.03 mg/kg) and after chronic oral nadolol therapy in patients who responded to intravenous nadolol (mean dose 83 ± 12 mg for 5 days). Intravenous nadolol administration prolonged mean sinus cycle length (p = 0. ... the atrium, ventricle or accessory bypass tracts. Oral nadolol had similar electrocardiographic and electrophysiologic effects, but of ...
Tópico(s): Cardiac electrophysiology and arrhythmias
1987 - Elsevier BV | The American Journal of Cardiology