Ram Devkota, Sara V. Brant, Arjun Thapa, Eric S. Loker,
... from the eggs/miracidia were consistent with Bivitellobilharzia nairi, reported here for the first time from Nepal. ... contained viable eggs indistinguishable from those of B. nairi. This identification was confirmed by comparison with both cox1 and 28S sequences from B. nairi eggs/miracidia derived from Nepalese and Sri Lankan ... work suggests that elephants and rhinos share B. nairi in CNP, even though these two members of ... and mode of definitive host infection for B. nairi have yet to be documented. This report also ...
Tópico(s): Wildlife Ecology and Conservation
2012 - Cambridge University Press | Journal of Helminthology
Takeshi Agatsuma, Jayanthe Rajapakse, V.Y. Kuruwita, Moritoshi Iwagami, R. M. R. Nilanthi,
Bivitellobilharzia nairi (Mudaliar and Ramanujachar, 1945) Dutt and Srivastava, 1955 was first recorded in India. A number of adult ... c oxidase subunit 1 (CO1) gene from B. nairi were analyzed. Two intraspecific variations were seen within ... analysis using the nuclear DNA showed that B. nairi was basal to all of species of the ... analysis using the mitochondrial DNA showed that B. nairi was nested within the genus Schistosoma. The taxonomical ...
Tópico(s): Zoonotic diseases and public health
2004 - Elsevier BV | Parasitology International
... nasale, S. incognitum, S. gimvicum (S.haematobium), Bivitellobilharzia nairi, Orientobilharzia bomfordi, O. dattai, O. turkestanicum and O. ... ecologies are not well studied. Species like B. nairi, O. bomfordi, O. harinasutai (Lymnaea rubiginosa intermediate host ...
Tópico(s): Global Maternal and Child Health
2017 - Elsevier BV | Acta Tropica
Sara V. Brant, Kateřina Jirků‐Pomajbíková, David Modrý, Klára J. Petrželková, Angelique Todd, Eric S. Loker,
... 28S sequences, our specimens grouped closely with B. nairi , the schistosome from the Indian elephant Elephas maximus, ... 12% distance cox 1) from those of B. nairi . We conclude the specimens we recovered were of ...
Tópico(s): Helminth infection and control
2012 - Cambridge University Press | Journal of Helminthology
Jayanthe Rajapakse, Moritoshi Iwagami, Saumya Wickramasinghe, Stephen Walker, Takeshi Agatsuma,
Abstract Bivitellobilharzia nairi was first recorded from an Indian elephant ( Elephas maximus ) in Berlin. Infections with this parasite have become increasingly ... correspond very well to the description of B. nairi by Dutt & Srivastava (1955). Moreover, it is clear that B. nairi is a distinctive species easily differentiated from other ... male worms shows that the surface of B. nairi is smoother than in other schistosomes.
Tópico(s): Helminth infection and control
2012 - Cambridge University Press | Journal of Helminthology
Sebastian Rehberg, Sandra Frank, Vladimír Černý, Radek Cihlář, Rainer Borgstedt, Gíanni Biancofiore, Fabio Guarracino, Andreas Schober, Helmut Trimmel, Thomas Pernerstorfer, Christian Siebers, P Dostál, Andrea Morelli, Michael Joannidis, Ingrid Pretsch, Christian Fuchs, Tim Rahmel, Matej Podbregar, Éva Duliczki, Kadri Tamme, Martin Unger, Jan Sus, Christoph Klade, Kurt Krejcy, Nairi Kirchbaumer-Baroian, Günther Krumpl, František Duška,
Excessive tachycardia in resuscitated septic shock patients can impair hemodynamics and worsen patient outcome. We investigated whether heart rate (HR) control can be achieved without increased vasopressor requirements using the titratable highly selective, ultra-short-acting β1-blocker landiolol.
Tópico(s): Sepsis Diagnosis and Treatment
2024 - Springer Science+Business Media | Intensive Care Medicine
Ainhoa Madariaga, Swati Garg, Naïri Tchrakian, Neesha C. Dhani, Waldo Jiménez, Stephen Welch, Helen Mackay, Josée-Lyne Ethier, Lucy Gilbert, Xuan Li, Angela Rodríguez, Lucy Chan, Valerie Bowering, Blaise Clarke, Tong Zhang, I. P. King, Gregory S. Downs, Tracy Stockley, Lisa Wang, Smitha Udagani, Amit M. Oza, Stéphanie Lheureux,
Abstract This multi-centre, non-randomized, open-label, phase II trial (NCT03016338), assessed niraparib monotherapy (cohort 1, C1), or niraparib and dostarlimab (cohort 2, C2) in patients with recurrent serous or endometrioid endometrial carcinoma. The primary endpoint was clinical benefit rate (CBR), with ≥5/22 overall considered of interest. Secondary outcomes were safety, objective response rate (ORR), duration of response, progression free survival and overall survival. Translational research was ...
Tópico(s): PARP inhibition in cancer therapy
2023 - Nature Portfolio | Nature Communications
W. Glenn McCluggage, Bárbara Rivera, Anne‐Sophie Chong, Blaise Clarke, Kris Ann P. Schultz, Louis P. Dehner, Naïri Tchrakian, María Apellániz-Ruiz, C. Blake Gilks, Friedrich Kommoss, Colin J.R. Stewart, William D. Foulkes,
Sertoli-Leydig cell tumors (SLCTs) are uncommon ovarian sex cord-stromal neoplasms which are currently classified into well, moderately, and poorly differentiated and retiform types. Well-differentiated SLCT is the least common and typically occurs in pure form, whereas moderately and poorly differentiated and retiform types often comprise a morphologic spectrum with an admixture of all 3. DICER1 pathogenic variants are very common in SLCTs but, as far as we are aware, have not been reported in well- ...
Tópico(s): Chromatin Remodeling and Cancer
2022 - Lippincott Williams & Wilkins | The American Journal of Surgical Pathology
Emily F. Thompson, Lynn Hoang, Anne Kathrin Höhn, Andrea Palicelli, Karen L. Talia, Naïri Tchrakian, Janine Senz, Rosebud Rusike, Suzanne Jordan, Amy Jamieson, Jutta Huvila, Jessica N. McAlpine, C. Blake Gilks, Michael Höckel, Naveena Singh, Lars‐Christian Horn,
Vulvar squamous cell carcinoma is subclassified into three prognostically relevant groups: (i) human papillomavirus (HPV) associated, (ii) HPV independent p53 abnormal (mutant pattern), and (iii) HPV independent p53 wild type. Immunohistochemistry for p16 and p53 serve as surrogates for HPV viral integration and TP53 mutational status. We assessed the reproducibility of the subclassification based on p16 and p53 immunohistochemistry and evaluated the prognostic significance of vulvar squamous cell carcinoma ...
Tópico(s): Sarcoma Diagnosis and Treatment
2022 - BMJ | International Journal of Gynecological Cancer
Margot van Riel, Nathalie Brison, Machteld Baetens, Bettina Blaumeiser, François Boemer, Laura Bourlard, Saskia Bulk, Anne De Leener, Julie Désir, Koenraad Devriendt, Annelies Dheedene, Armelle Duquenne, Nathalie Fieremans, Annelies Fieuw, Jean‐Stéphane Gatot, Bernard Grisart, Sandra Janssens, Naïri Khudashvili, Lore Lannoo, Axel Marichal, Colombine Meunier, Léonor Palmeira, Ilse Parijs, Bruno Pichon, Ellen Roets, Eva Sammels, Guillaume Smits, Marion Suenaert, Yves Sznajer, Kris Van Den Bogaert, Leen Vancoillie, Lotte Vandeputte, Elise Vantroys, Joris Vermeesch, Katrien Janssens,
OBJECTIVE: To evaluate the accuracy and diagnostic value of genome-wide noninvasive prenatal testing (NIPT) for the detection of fetal aneuploidies in multiple gestations, with a focus on dichorionic–diamniotic twin pregnancies. METHODS: We performed a retrospective cohort study including data from pregnant women with a twin or higher-order gestation who underwent genome-wide NIPT at one of the eight Belgian genetic centers between November 1, 2013, and March 1, 2020. Chorionicity and amnionicity ...
Tópico(s): Fetal and Pediatric Neurological Disorders
2021 - Lippincott Williams & Wilkins | Obstetrics and Gynecology
Christian Dalton‐Locke, Sonia Johnson, Jasmine Harju‐Seppänen, Natasha Lyons, Luke Sheridan Rains, Ruth Stuart, Amelia Campbell, Jeremy Clark, Aisling Clifford, Laura Courtney, Ceri Dare, Kathleen Kelly, Chris Lynch, Paul McCrone, Shilpa Nairi, Karen Newbigging, Patrick Nyikavaranda, David Osborn, Karen Persaud, Martin Stefan, Brynmor Lloyd‐Evans,
Inpatient psychiatric care is unpopular and expensive, and development and evaluation of alternatives is a long-standing policy and research priority around the world. In England, the three main models documented over the past fifty years (teams offering crisis assessment and treatment at home; acute day units; and residential crisis services in the community) have recently been augmented by several new service models. These are intended to enhance choice and flexibility within catchment area acute ...
Tópico(s): Emergency and Acute Care Studies
2021 - BioMed Central | BMC Health Services Research
Sabina Alkire, Ricardo Nogales, Natalie Naïri Quinn, Nicolai Suppa,
According to the global Multidimensional Poverty Index (MPI), an internationally comparable measure, poverty in developing countries has fallen substantially over the last 15 years. The COVID-19 pandemic and associated economic contraction are negatively impacting multiple dimensions of poverty and jeopardising this progress. This paper uses recent assessments of food insecurity and school closures made by UN agencies to inform microsimulations of potential short-term impacts of the pandemic under ...
Tópico(s): Agricultural risk and resilience
2021 - Elsevier BV | Social Science & Medicine
Christopher R. Carlson, Jonathan B Asfaha, Chloe M. Ghent, Conor J Howard, Nairi Hartooni, Maliheh Safari, Alan D. Frankel, David O. Morgan,
Tópico(s): Nuclear Structure and Function
2020 - Elsevier BV | Molecular Cell
Melissa V. Fernandez, Huxley K. Hoffman, Nairi Pezeshkian, Philip R. Tedbury, Schuyler B. van Engelenburg, Eric O. Freed,
The HIV-1 Env cytoplasmic tail (CT) is required for efficient Env incorporation into nascent particles and viral transmission in primary CD4 + T cells. The MT-4 T-cell line has been reported to support multiple rounds of infection of HIV-1 encoding a gp41 CT truncation. Uncovering the underlying mechanism of MT-4 T-cell line permissivity to gp41 CT truncation would provide key insights into the role of the gp41 CT in HIV-1 transmission. This study reveals that multiple factors contribute to the unique ...
Tópico(s): T-cell and B-cell Immunology
2020 - American Society for Microbiology | Journal of Virology
Anthony W. Martinelli, Tejas Ingle, Joseph Newman, Iftikhar Nadeem, Karl Jackson, Nicholas D. Lane, J. Mark Melhorn, Helen Davies, Anthony Rostron, Aldrin Adeni, Kevin Conroy, N. Woznitza, M. Jeremiah Matson, Simon Brill, James R. D. Murray, Amar Shah, Revati Naran, Samanjit S Hare, Oliver Collas, Sarah Bigham, Michael Spiro, Margaret M. Huang, Beenish Iqbal, Sarah J. Trenfield, Stéphane Ledot, Sujal R. Desai, Lewis Standing, Judith Babar, Razeen Mahroof, Ian Smith, Kai Lee, Naïri Tchrakian, Stephanie Uys, William Ricketts, Anant Patel, Avinash Aujayeb, Maria Kokosi, Alex Wilkinson, Stefan J. Marciniak,
Introduction Pneumothorax and pneumomediastinum have both been noted to complicate cases of coronavirus disease 2019 (COVID-19) requiring hospital admission. We report the largest case series yet described of patients with both these pathologies (including nonventilated patients). Methods Cases were collected retrospectively from UK hospitals with inclusion criteria limited to a diagnosis of COVID-19 and the presence of either pneumothorax or pneumomediastinum. Patients included in the study presented ...
Tópico(s): Respiratory Support and Mechanisms
2020 - European Respiratory Society | European Respiratory Journal
Norman F. Truong, Evan Kurt, Nairi Tahmizyan, Sasha Cai Lesher‐Pérez, Mabel Chen, Nicole J. Darling, Weixian Xi, Tatiana Segura,
Designing scaffolds for polyplex-mediated therapeutic gene delivery has a number of applications in regenerative medicine, such as for tissue repair after wounding or disease. Microporous annealed particle (MAP) hydrogels are an emerging class of porous biomaterials, formed by annealing microgel particles to one another in situ to form a porous bulk scaffold. MAP gels have previously been shown to support and enhance proliferative and regenerative behaviors both in vitro and in vivo. Therefore, coupling ...
Tópico(s): Nerve injury and regeneration
2019 - Elsevier BV | Acta Biomaterialia
Hui Gao, Zongzhen Li, Shaoxiong Zhou, Guangqiang Zhang, Nairi Cui,
The influence of melt overheating on the viscosity of the melt and surface quality of the Fe78Si9B13 melt-spun ribbons have been studied by using oscillating vessel viscometry, X-ray diffraction, transmission electron microscopy, and field emission scanning electron microscopy. A critical temperature Tc (about 1350 °C) of the melt transformation was determined via viscosity measurements during overheating and subsequent cooling processes. The Fe78Si9B13 amorphous ribbons were produced through planar ...
Tópico(s): Fashion and Cultural Textiles
2019 - Elsevier BV | Progress in Natural Science Materials International
Nairi Pezeshkian, Nicholas S. Groves, Schuyler B. van Engelenburg,
The HIV-1 envelope glycoprotein (Env) is sparsely incorporated onto assembling virus particles on the host cell plasma membrane in order for the virus to balance infectivity and evade the immune response. Env becomes trapped in a nascent particle on encounter with the polymeric viral protein Gag, which forms a dense protein lattice on the inner leaflet of the plasma membrane. While Env incorporation efficiency is readily measured biochemically from released particles, very little is known about the ...
Tópico(s): Cytomegalovirus and herpesvirus research
2019 - National Academy of Sciences | Proceedings of the National Academy of Sciences
Valentina Nairi, Silvia Magnolia, Marco Piludu, Mariella Nieddu, Cristian Antonio Caria, Valeria Sogos, María Vallet‐Regí, Maura Monduzzi, Andrea Salis,
Mesoporous silica nanoparticles (MSNs) were functionalized with amino groups (MSN-NH2) and then with hyaluronic acid, a biocompatible biopolymer which can be recognized by CD44 receptors in tumor cells, to obtain a targeting drug delivery system. To this purpose, three hyaluronic acid samples differing for the molecular weight, namely HAS (8–15 kDa), HAM (30–50 kDa) and HAL (90–130 kDa), were used. The MSN-HAS, MSN-HAM, and MSN-HAL materials were characterized through zeta potential and dynamic light ...
Tópico(s): Bone Tissue Engineering Materials
2018 - Elsevier BV | Colloids and Surfaces B Biointerfaces
Hassan Askari, Mohammad Foad Abazari, Pegah Ghoraeian, Sepehr Torabinejad, Maryam Nouri Aleagha, Reza Mirfallah Nassiri, Farshid Tahmasebi, Nairi Abedi, Sulail Fatima Rajani, Ali Salarian, Maryam Belaran, Mohammed Elshiekh, Nima Sanadgol,
Tópico(s): Nitric Oxide and Endothelin Effects
2018 - Springer Science+Business Media | Metabolic Brain Disease
Frauke von Versen‐Höynck, Nairi Strauch, Jing Liu, Yueh-Yun Chi, Maureen Keller-Woods, Kirk P. Conrad, Valerie L. Baker,
To investigate how the mode of conception affects maternal relaxin, creatinine, and electrolyte concentrations. Pregnancies achieved by fertility treatment often begin in a nonphysiologic endocrine milieu with no corpus luteum (CL) or with many corpora lutea. The CL produces not only estradiol and progesterone but is also the sole source of relaxin in early pregnancy, a hormone that may contribute to maternal systemic and renal vasodilation. There is limited data about maternal physiology in early ...
Tópico(s): Ectopic Pregnancy Diagnosis and Management
2018 - Springer Nature | Reproductive Sciences
Valentina Nairi, Sara Medda, Marco Piludu, Maria F. Casula, María Vallet‐Regí, Maura Monduzzi, Andrea Salis,
Biomedical application of nanoparticles is largely associated to their fate in biological media which, in turn, is related to their surface properties. Surface functionalization plays a key role in determining biodegradation, cytotoxicity and biodistribution through interactions which may be mediated by the macromolecules occurring in biological media. A typical example is given by several proteins which lead to the formation of coated nanoparticles referred as protein corona. In this work we focus ...
Tópico(s): Surfactants and Colloidal Systems
2018 - Elsevier BV | Chemical Engineering Journal
Carmen A. Buttler, Nairi Pezeshkian, Melissa V. Fernandez, Jesse Aaron, Sofya Norman, Eric O. Freed, Schuyler B. van Engelenburg,
Human immunodeficiency virus type 1 (HIV-1) assembly occurs on the inner leaflet of the host cell plasma membrane, incorporating the essential viral envelope glycoprotein (Env) within a budding lattice of HIV-1 Gag structural proteins. The mechanism by which Env incorporates into viral particles remains poorly understood. To determine the mechanism of recruitment of Env to assembly sites, we interrogate the subviral angular distribution of Env on cell-associated virus using multicolor, three-dimensional ( ...
Tópico(s): Herpesvirus Infections and Treatments
2018 - Nature Portfolio | Nature Communications
Hayk Sedrakyan, Nairi Sedrakyan,
Tópico(s): Mathematics and Applications
2018 - Springer Nature | Problem books in mathematics
Andrea Grüber, Martin Czejka, Philipp Buchner, M. Kitzmueller, Nairi Baroian, Christian Dittrich, Azra Sahmanovic Hrgovcic,
In this study, a therapeutic drug monitoring (TDM) of erlotinib in pancreatic cancer patients was performed over 50 weeks to reveal possible alterations in erlotinib plasma concentrations. Additionally, a physiologically based pharmacokinetic (PBPK) model was created to assess such variations in silico. Patients with advanced pancreatic cancer received a chemotherapeutic combination of 100 mg erlotinib q.d., 500–900 mg capecitabine b.d. and 5 mg/kg bevacizumab q.2wks. Samples were analyzed by HPLC ...
Tópico(s): Lung Cancer Treatments and Mutations
2018 - Springer Science+Business Media | Cancer Chemotherapy and Pharmacology
Valentina Nairi, Luca Medda, Maura Monduzzi, Andrea Salis,
In this work the adsorption and the release of ampicillin - a β-lactam penicillin-like antibiotic - from MCM-41, SBA-15, and (amino functionalized) SBA-15-NH2 ordered mesoporous silica (OMS) materials were investigated. The silica matrices differ for their pore size (SBA-15 vs. MCM-41) mainly, and also for surface charge (SBA-15 and MCM-41, vs. SBA-15-NH2). OMS samples were characterized through small-angle X-rays scattering (SAXS), transmission electron microscopy (TEM), N2 adsorption–desorption isotherms, ...
Tópico(s): Layered Double Hydroxides Synthesis and Applications
2017 - Elsevier BV | Journal of Colloid and Interface Science
Gonzalo Villaverde, Valentina Nairi, Alejandro Baeza, María Vallet‐Regí,
Abstract The selective transportation of therapeutic agents to tumoral cells is usually achieved by their conjugation with targeting moieties able to recognize these cells. Unfortunately, simple and static targeting systems usually show a lack in selectivity. Herein, a double sequential encrypted targeting system is proposed as a stimuli‐responsive targeting analogue for selectivity enhancement. The system is able to recognize diseased bone tissue in the first place, and once there, a hidden secondary ...
Tópico(s): RNA Interference and Gene Delivery
2017 - Wiley | Chemistry - A European Journal
Naïri Usher, Matty J. Hoban, Dan E. Browne,
A central result in the study of Quantum Hamiltonian Complexity is that the k-Local hamiltonian problem is QMA-complete. In that problem, we must decide if the lowest eigenvalue of a Hamiltonian is bounded below some value, or above another, promised one of these is true. Given the ground state of the Hamiltonian, a quantum computer can determine this question, even if the ground state itself may not be efficiently quantum preparable. Kitaev's proof of QMA-completeness encodes a unitary quantum ...
Tópico(s): Quantum Mechanics and Applications
2017 - American Physical Society | Physical review. A/Physical review, A
Ana Maria Săcară, Valentina Nairi, Andrea Salis, Graziella Liana Turdean, Liana Maria Mureşan,
Abstract New silica‐modified glassy carbon electrodes prepared with three different sorts of ordered mesoporous silica (OMS) were characterized and tested for the electrochemical detection of Malachite Green (MG). The electrodes were prepared by drop casting using silica suspensions and, for stability sake, a Nafion coating was deposited on the electrode top by the same technique. Square wave anodic stripping voltammetry was used to investigate the effect of various experimental parameters (deposition ...
Tópico(s): Aquaculture disease management and microbiota
2017 - Wiley | Electroanalysis
Thomas U. Ahearn, Naïri Tchrakian, Kathryn M. Wilson, Rosina T. Lis, Elizabeth Nuttall, Howard D. Sesso, Massimo Loda, Edward L. Giovannucci, Lorelei A. Mucci, Stephen P. Finn, Irene M. Shui,
Prostate cancer metastases preferentially target bone, and the calcium-sensing receptor (CaSR) may play a role in promoting this metastatic progression. We evaluated the association of prostate tumor CaSR expression with lethal prostate cancer. A validated CaSR immunohistochemistry assay was performed on tumor tissue microarrays. Vitamin D receptor (VDR) expression and phosphatase and tensin homolog tumor status were previously assessed in a subset of cases by immunohistochemistry. Cox proportional ...
Tópico(s): Thyroid Disorders and Treatments
2016 - Oxford University Press | The Journal of Clinical Endocrinology & Metabolism