Seisho Takeuchi, Naoko Takeuchi, Kunihiro Tsukasaki, Claus R. Bartram, Martin Zimmermann, Martin Schrappe, Hirokuni Taguchi, H. Phillip Koeffler,
Summary. Genetic polymorphisms in the tumour necrosis factor (TNF) locus influence the outcome of non‐Hodgkin's lymphoma (NHL). We investigated whether these polymorphisms might contribute to the clinical course of childhood acute lymphoblastic leukaemia (ALL). Genomic DNA from 214 childhood ALL patients was analysed. Patients with a high‐risk haplotype were older than patients with low‐risk haplotype ( P = 0·024). No statistically significant associations were found between TNF haplotype and sex, WBC ...
Tópico(s): Lung Cancer Research Studies
2002 - Wiley | British Journal of Haematology
W.‐K. Hofmann, Seisho Takeuchi, Naoko Takeuchi, E. Thiel, D. Hoelzer, H. Phillip Koeffler,
Hypermethylation of CpG islands within the promoter region is one of the mechanisms by which genes are inactivated and may be one of the reason for silencing of cell cycle control or DNA-mismatch repair genes in myelodysplastic syndrome (MDS). Since the function of cell cycle control genes including the cyclin-dependent kinase inhibitors known as p15INK4b and p16INK4a, as well as p14ARF which blocks MDM-2 (an inhibitor of p53), the retinoblastoma (RB1) protein and the mismatch repair gene MGMT is critical ...
Tópico(s): RNA modifications and cancer
2006 - Elsevier BV | Leukemia Research
Seisho Takeuchi, Wolf‐Karsten Hofmann, Kunihiro Tsukasaki, Naoko Takeuchi, Takayuki Ikezoe, Masahide Matsushita, Yoshio Uehara, H. Phillip Koeffler,
Adult T-cell leukaemia/lymphoma (ATL) is associated with the monoclonal integration of human T-lymphotropic virus type I (HTLV-I) proviral DNA into tumour cells, but the incidence of ATL is low (2–5%) among HTLV-I carriers; and those who develop the disease usually have a 40- to 60-year latency period from the time of infection to progression to ATL. These phenomena suggest that additional mechanisms are involved in the progress of the disease, such as inactivation of tumour suppressor genes, or activation ...
Tópico(s): T-cell and Retrovirus Studies
2007 - Wiley | British Journal of Haematology
Seisho Takeuchi, Taku Seriu, Jacques J. M. van Dongen, Tomasz Szczepański, Kunihiro Tsukasaki, Naoko Takeuchi, Anthony C. Fermin, Hiromi Seo, Claus R. Bartram, H. Phillip Koeffler,
Tópico(s): Epigenetics and DNA Methylation
2003 - Springer Nature | Oncogene
Seisho Takeuchi, Kunihiro Tsukasaki, Claus R. Bartram, Taku Seriu, M Zimmermann, Martin Schrappe, Naoko Takeuchi, S Park, Hirokuni Taguchi, H. Phillip Koeffler,
Tópico(s): RNA modifications and cancer
2003 - Springer Nature | Leukemia
Jeffrey A. Fawcett, Ryoma Takeshima, Shinji Kikuchi, Euki Yazaki, Tomoyuki Katsube‐Tanaka, Yumei Dong, Meifang Li, Harriet V. Hunt, Martin K. Jones, Diane L. Lister, Takanori Ohsako, Eri Ogiso‐Tanaka, Kenichiro Fujii, Takashi Hara, Katsuhiro Matsui, Nobuyuki Mizuno, Kazusa Nishimura, Tetsuya Nakazaki, Hiroki Saito, Naoko Takeuchi, Mariko Ueno, Daiki Matsumoto, Miyu Norizuki, Kenta Shirasawa, Chengyun Li, Hideki Hirakawa, Tatsuya Ota, Y. Yasui,
Tópico(s): Genetic and Environmental Crop Studies
2023 - Nature Portfolio | Nature Plants
Kazuma Nagata, Takeo Horie, Naohiko Chohnabayashi, Torahiko Jinta, Ryosuke Tsugitomi, Akira Shiraki, Fumiaki Tokioka, Toru Kadowaki, Akira Watanabe, Motonari Fukui, Takamasa Kitajima, Susumu Satō, Toru Tsuda, Nobuhito Kishimoto, Hideo Kita, Yoshihiro Mori, Masayuki Nakayama, Kenichi Takahashi, Tomomasa Tsuboi, Makoto Yoshida, Osamu Hataji, Satoshi Fuke, Michiko Kagajo, Hiroki Nishine, Hiroyasu Kobayashi, Hiroyuki Nakamura, Miyuki Okuda, Sayaka Tachibana, Shohei Takata, Hisayuki Osoreda, Kenichi Minami, Takashi Nishimura, Tadashi Ishida, Jiro Terada, Naoko Takeuchi, Yasuo Kohashi, Hiromasa Inoue, Yoko Nakagawa, Takashi Kikuchi, Keisuke Tomii,
Rationale: The long-term effects of using a high-flow nasal cannula for chronic hypercapnic respiratory failure caused by chronic obstructive pulmonary disease remain unclear. Objectives: To assess whether long-term high-flow nasal cannula use reduces the number of exacerbations and improves other physiological parameters in patients with chronic hypercapnic respiratory failure caused by chronic obstructive pulmonary disease. Methods: We enrolled 104 participants (aged ⩾40 yr) with daytime hypercapnia ( ...
Tópico(s): Neonatal Respiratory Health Research
2022 - American Thoracic Society | American Journal of Respiratory and Critical Care Medicine
... la japonesa Sailor Moon, creada en 1992 por Naoko Takeuchi, pues es, a su vez, una de las ...
Tópico(s): Asian Culture and Media Studies
2018 - Technical University of Valencia | Con A de animación
Akihiro Tamiya, Motohiro Tamiya, Takashi Nishihara, Takayuki Shiroyama, Keiko Nakao, Taisuke Tsuji, Naoko Takeuchi, Shun‐ichi Isa, Naoki Omachi, Norio Okamoto, Hidekazu Suzuki, Kyoichi Okishio, Ayano Iwazaki, Kimie Imai, Tomonori Hirashima, Shinji Atagi,
Background: Afatinib is an effective first-line treatment for epidermal growth factor receptor (EGFR) mutation-positive advanced non-small cell lung cancer (NSCLC). However, few reports have addressed the influence of cerebrospinal fluid (CSF) penetration rate on the efficacy of afatinib in patients with central nervous system metastases. Therefore, we conducted a prospective multicenter trial to evaluate the CSF penetration rate and efficacy of afatinib in patients with EGFR mutation-positive NSCLC ...
Tópico(s): Lung Cancer Research Studies
2017 - International Institute of Anticancer Research (IIAR) Conferences 1997. Athens, Greece. Abstracts | Anticancer Research
Yoshihito Fujita, Satoru Moriyama, Satoshi Aoki, Saya Yoshizawa, Maiko Tomita, Taiki Kojima, Yukiko Mori, Naoko Takeuchi, MinHye So, Motoki Yano, Kazuya Sobue,
Although maintaining anesthesia for myasthenia gravis (MG) with minimal muscle relaxants (MR) is common, the success rate of anesthetic management for MG without MR is not clear. We therefore retrospectively examined the success rate of anesthetic management for MG without MR among 66 consecutive cases of thymectomy for MG performed at our hospital between January 2004 and April 2010, before approval of using sugammadex. A total of 60 patients (90.9 %) were treated without MR (N group). Among the 60 cases, ...
Tópico(s): Pituitary Gland Disorders and Treatments
2015 - Springer Science+Business Media | Journal of Anesthesia
Akihiro Tamiya, Motohiro Tamiya, Takayuki Shiroyama, Nobuhiko Saijo, Takeshi Nakatani, Shojiro Minomo, Taisuke Tsuji, Naoko Takeuchi, Naoki Omachi, Kanako Kurata, Hidekazu Suzuki, Norio Okamoto, Kyoichi Okishio, Tomonori Hirashima, Shinji Atagi,
Tópico(s): Colorectal Cancer Treatments and Studies
2015 - Springer Science+Business Media | Medical Oncology
Mark Ravinet, Naoko Takeuchi, Manabu Kume, Seiichi Mori, Jun Kitano,
Divergent selection and adaptive divergence can increase phenotypic diversification amongst populations and lineages. Yet adaptive divergence between different environments, habitats or niches does not occur in all lineages. For example, the colonization of freshwater environments by ancestral marine species has triggered adaptive radiation and phenotypic diversification in some taxa but not in others. Studying closely related lineages differing in their ability to diversify is an excellent means ...
Tópico(s): Identification and Quantification in Food
2014 - Public Library of Science | PLoS ONE
Toru Arai, Yoshikazu Inoue, Chikatoshi Sugimoto, Yasushi Inoue, Keiko Nakao, Naoko Takeuchi, Akiko Matsumuro, Masaki Hirose, Koh Nakata, Seiji Hayashi,
Serum markers, including Krebs von den Lungen (KL-6), surfactant protein (SP)-D, SP-A and carcinoembryonic antigen (CEA), are reported to reflect autoimmune pulmonary alveolar proteinosis (APAP) disease severity. We evaluated serum CYFRA21-1 levels as a marker of APAP.In addition to KL-6, SP-D and CEA, we prospectively measured serum CYFRA 21-1 levels in 48 patients with APAP, consecutively diagnosed between 2002 and 2010. Diagnostic usefulness of CYFRA 21-1 was determined from 68 patients with interstitial ...
Tópico(s): Medical Imaging and Pathology Studies
2013 - Wiley | Respirology
Asano Ishikawa, Naoko Takeuchi, Masashi Kusakabe, Manabu Kume, Seiichi Mori, Hiroshi Takahashi, Jun Kitano,
Although similar patterns of phenotypic diversification are often observed in phylogenetically independent lineages, differences in the magnitude and direction of phenotypic divergence have been also observed among independent lineages, even when exposed to the same ecological gradients. The stickleback family is a good model with which to explore the ecological and genetic basis of parallel and nonparallel patterns of phenotypic evolution, because there are a variety of populations and species ...
Tópico(s): Plant and animal studies
2013 - Oxford University Press | Journal of Evolutionary Biology
Katherine A. Harrisson, Alexandra Pavlova, J. Nevil Amos, Naoko Takeuchi, Alan Lill, James Q. Radford, Paul Sunnucks,
Tópico(s): Conservation, Biodiversity, and Resource Management
2012 - Springer Science+Business Media | Landscape Ecology
Katherine A. Harrisson, Alexandra Pavlova, J. Nevil Amos, Naoko Takeuchi, Alan Lill, James Q. Radford, Paul Sunnucks,
Summary Understanding how habitat fragmentation affects population processes (e.g. dispersal) at different spatial scales is of critical importance to conservation. We assessed the effects of habitat fragmentation on dispersal and regional and fine‐scale population structure in a currently widespread and common cooperatively breeding bird species found across south‐eastern A ustralia, the superb fairy‐wren M alurus cyaneus . Despite its relative abundance and classification as an urban tolerant species, ...
Tópico(s): Animal Behavior and Reproduction
2012 - Wiley | Journal of Animal Ecology
Alexandra Pavlova, J. Nevil Amos, Maria I. Goretskaia, I. R. Beme, Katherine L. Buchanan, Naoko Takeuchi, James Q. Radford, Paul Sunnucks,
Understanding the processes leading to population declines in fragmented landscapes is essential for successful conservation management. However, isolating the influence of disparate processes, and dispersal in particular, is challenging. The Grey Shrike-thrush, Colluricincla harmonica, is a sedentary woodland-dependent songbird, with learned vocalizations whose incidence in suitable habitat patches falls disproportionally with decline in tree cover in the landscape. Although it has been suggested ...
Tópico(s): Avian ecology and behavior
2012 - Wiley | Ecology
Kenichi Nishie, Tomoya Kawaguchi, Akihiro Tamiya, Tomoyasu Mimori, Naoko Takeuchi, Yoshinobu Matsuda, Naoki Omachi, Kazuhiro Asami, Kyoichi Okishio, Shinji Atagi, Tomohisa Okuma, Akihito Kubo, Yoshihito Maruyama, Shinzoh Kudoh, Minoru Takada,
Tópico(s): Cancer therapeutics and mechanisms
2012 - Elsevier BV | Journal of Thoracic Oncology
J. Nevil Amos, S. Balasubramaniam, L. Grootendorst, Katherine A. Harrisson, Alan Lill, Ralph Mac Nally, Alexandra Pavlova, James Q. Radford, Naoko Takeuchi, James R. Thomson, Paul Sunnucks,
Habitat loss, fragmentation and degradation are drivers of major declines in biodiversity and species extinctions. The actual causes of species population declines following habitat change are more difficult to discern and there is typically high covariation among the measures used to infer the causes of decline. The causes of decline may act directly on individual fitness and survival, or through disruption of population processes. We examined the relationships among configuration, extent and status ...
Tópico(s): Bird parasitology and diseases
2012 - Wiley | Journal of Avian Biology
Kazuhiro Asami, Tomohisa Okuma, Tomonori Hirashima, Masaaki Kawahara, Shinji Atagi, Tomoya Kawaguchi, Kyoichi Okishio, Naoki Omachi, Naoko Takeuchi,
Gefitinib is an effective treatment for patients with non-small cell lung cancer who harbor activating epidermal growth factor receptor (EGFR) mutations. However, no optimal strategy has been established for these patients after gefitinib fails. The aim of this retrospective study was to assess the survival benefit of continued gefitinib treatment in these cases.We analyzed gefitinib responders with activating EGFR mutations who developed progressive disease (PD) during the course of therapy. Prognostic ...
Tópico(s): Peptidase Inhibition and Analysis
2012 - Elsevier BV | Lung Cancer
Michael Griesser, Nicole A. Schneider, Mary-Anne Collis, Anthony Overs, M. Guppy, Sarah Guppy, Naoko Takeuchi, Pete Collins, Anne Peters, Michelle L. Hall,
One of the main techniques for recognizing individuals in avian field research is marking birds with plastic and metal leg rings. However, in some species individuals may react negatively to rings, causing leg injuries and, in extreme cases, the loss of a foot or limb. Here, we report problems that arise from ringing and illustrate solutions based on field data from Brown Thornbills (Acanthiza pusilla) (2 populations), Siberian Jays (Perisoreus infaustus) and Purple-crowned Fairy-wrens (Malurus coronatus). ...
Tópico(s): Animal Behavior and Reproduction
2012 - Public Library of Science | PLoS ONE
Tópico(s): Fish Biology and Ecology Studies
2008 - Springer Science+Business Media | Ichthyological Research
Xiangdong Deng, Noriaki Sagata, Naoko Takeuchi, Masami Tanaka, Hideaki Ninomiya, Nakao Iwata, Norio Ozaki, Hiroki Shibata, Yasuyuki Fukumaki,
Abstract Background Based on the glutamatergic dysfunction hypothesis for schizophrenia pathogenesis, we have been performing systematic association studies of schizophrenia with the genes involved in glutametergic transmission. We report here association studies of schizophrenia with SLC1A4 , SLC1A5 encoding neutral amino acid transporters ASCT1, ASCT2, and SLC6A5 , SLC6A9 encoding glycine transporters GLYT2, GLYT1, respectively. Methods We initially tested the association of 21 single nucleotide polymorphisms ( ...
Tópico(s): Neuroscience and Neuropharmacology Research
2008 - BioMed Central | BMC Psychiatry
Xiangdong Deng, Hiroki Shibata, Naoko Takeuchi, Shinako Rachi, Mayumi Sakai, Hideaki Ninomiya, Nakao Iwata, Norio Ozaki, Yasuyuki Fukumaki,
Abstract Based on the glutamatergic dysfunction hypothesis for schizophrenia pathogenesis, we have been performing systematic association studies of schizophrenia with the glutamate receptor and transporter genes. We report here association studies of schizophrenia with three glutamate transporter genes SLC1A1 , SLC1A3 , and SLC1A6 encoding the glutamate transporters EAAT3, EAAT1, and EAAT4, respectively. We initially performed the screening of the total 25 single nucleotide polymorphisms (SNPs) distributed ...
Tópico(s): Receptor Mechanisms and Signaling
2007 - Wiley | American Journal of Medical Genetics Part B Neuropsychiatric Genetics
Yōichi Shibusawa, Naoko Takeuchi, Kazusa Sugawara, Akio Yanagida, Heisaburo Shindo, Yoichiro Ito,
Tópico(s): Phytochemistry and biological activity of medicinal plants
2006 - Elsevier BV | Journal of Chromatography B
Asao Ogawa, Ichiro Mizuta, Tomoko Fukunaga, Naoko Takeuchi, Eiko Honaga, Yoshiro Sugita, Akira Mikami, Yoichi Inoue, Masatoshi Takeda,
Abstract Eating disorders are common psychiatric disorders in young women. The aim of the present study was to evaluate the gastric electrical acitivity of patients with eating disorders and its relation to their symptoms. The electrogastrography (EGG) was performed before and after a water load test for outpatients with eating disorders ( n = 36; 14 anorexia nervosa, 14 bulimia nervosa, eight eating disorder not otherwise specified) and healthy women ( n = 19). A structured interview (Eating Disorder Examination) ...
Tópico(s): Biochemical Analysis and Sensing Techniques
2004 - Wiley | Psychiatry and Clinical Neurosciences
Yoriko Murata, Yasuhiro Ogawa, Toshiji Saibara, Akihito Nishioka, Naoko Takeuchi, Shinji Kariya, Saburo Onishi, Shōji Yoshida,
We have evaluated the distribution of fatty infiltration in the liver for determination of a suitable biopsy site for diagnosis of tamoxifen-induced non-alcoholic steatohepatitis (NASH) in patients with breast cancer. Thirty-eight consecutive breast cancer patients undergoing tamoxifen treatment were analyzed by CT to identify hepatic steatosis (HS) via calculation of the liver/spleen CT ratio in Couinaud's 8 areas. We defined hepatic fatty infiltration as a liver/spleen ratio of less than 0.9. The ...
Tópico(s): Hepatocellular Carcinoma Treatment and Prognosis
2003 - Elsevier BV | Oncology Reports
Naoko Takeuchi, Takahiko Kawamura, Akio Kanai, Nobuhisa Nakamura, Tomoko Uno, Tasuku Hara, Takahisa Sano, N. Sakamoto, Yuichi Hamada, Jun Nakamura, Norio Hotta,
Abstract Aims To investigate the effect of smoking on soluble adhesion molecules in middle‐aged diabetic patients. Methods One hundred out‐patients with Type 2 diabetes and 100 age‐ and sex‐matched non‐diabetic subjects without clinical macrovascular disease were selected. Soluble serum levels of adhesion molecules were analysed using enzyme immunoassay. Carotid atherosclerosis was assessed using an ultrasound system. Results When compared with non‐diabetic subjects, soluble vascular cell adhesion ...
Tópico(s): Cerebrovascular and Carotid Artery Diseases
2002 - Wiley | Diabetic Medicine
Wolf‐Karsten Hofmann, Kunihiro Tsukasaki, Naoko Takeuchi, Seisho Takeuchi, H. Phillip Koeffler,
Central to many cancers is the aberrant expression of genes that regulate the cell cycle including the cyclin-dependent kinase inhibitors known as p15INK4b and p16INK4a, p14ARF and the retinoblastoma (RB) protein. We performed a detailed analysis of the methylation status of these genes by methylation specific polymerase chain reaction (MSP) in tumor cells of 35 adult T-cell leukemia/lymphoma (ATL) patients. We found in nine of 35 cases (26%) at least one gene methylated. The frequency of p15INK4b methylation ...
Tópico(s): Epigenetics and DNA Methylation
2001 - Taylor & Francis | Leukemia & lymphoma/Leukemia and lymphoma
J Ikezoe, Naoko Takeuchi, Takeshi Johkoh, Naoyuki Kohno, Noriyuki Tomiyama, T. Kozuka, K Noma, E Ueda,
It has been stated, but not adequately assessed, that pulmonary tuberculosis in diabetic or immunocompromised patients often has an atypical pattern and distribution. To evaluate the CT features of pulmonary tuberculosis in diabetic or immunocompromised patients compared with patients without underlying disease, we performed this retrospective study. We reviewed conventional CT scans (n = 100) and high-resolution CT scans (n = 16) of the chest in 110 adult patients with active postprimary tuberculosis. ...
Tópico(s): Diagnosis and treatment of tuberculosis
1992 - American Roentgen Ray Society | American Journal of Roentgenology