Masato Yamaguchi, Masami Shimizu, Hidekazu Ino, Hidenobu Terai, Kenshi Hayashi, Tomoya Kaneda, Hiroshi Mabuchi, Ryo Sumita, Tohru Oshima, Naoto Hoshi, Haruhiro Higashida,
LQTS (long QT syndrome) is an inherited cardiac disorder characterized by prolongation of QT interval, torsades de pointes and sudden death. We have identified two heterozygous missense mutations in the KCNQ1 and KCNH2 (also known as HERG) genes [Asp611→Tyr (D611Y) in KCNQ1 and Asp609→Gly (D609G) in KCNH2] in a 2-year-old boy with LQTS. The aim of the present study was to characterize the contributions of the mutations in the KCNQ1 and KCNH2 genes relative to the clinical manifestations and electrophysiological ...
Tópico(s): Receptor Mechanisms and Signaling
2005 - Portland Press | Clinical Science
Tsutomu Sato, Takashi Oshima, Naoto Yamamoto, Takanobu Yamada, Shinichi Hasegawa, Norio Yukawa, Kazushi Numata, Chikara Kunisaki, Katsuaki Tanaka, Manabu Shiozawa, Takaki Yoshikawa, Makoto Akaike, Yasushi Rino, Toshio Imada, Munetaka Masuda,
Purpose Secreted protein acidic and rich in cysteine (SPARC) is one of the first known matricellular proteins that modulates interactions between cells and extracellular matrix. Recent studies investigated the clinical significance of SPARC gene expression in the development, progression, and metastasis of cancer. The present study examined the relations of the relative expression of the SPARC gene to clinicopathological factors and overall survival in patients with gastric cancer. Methods We studied ...
Tópico(s): Cancer Research and Treatments
2013 - Wiley | Journal of Surgical Oncology
Yoshinori Aoki, Hongmei Dai, Fumika Furuta, Tomohisa Akamatsu, Takuya Oshima, Naoto Takahashi, Yu‐ichi Goto, Akira Oka, Masayuki Itoh,
Abstract Background Microglial cells play an important role in the immune system in the brain. Activated microglial cells are not only injurious but also neuroprotective. We confirmed marked lectin-like oxidized low-density lipoprotein receptor-1 (LOX-1) expression in microglial cells in pathological lesions in the neonatal hypoxic-ischemic encephalopathy (nHIE) model brain. LOX-1 is known to be an activator of cytokines and chemokines through intracellular pathways. Here, we investigated a novel ...
Tópico(s): Atherosclerosis and Cardiovascular Diseases
2023 - BioMed Central | Cell Communication and Signaling
Hiromu Katamoto, Hiroshi Fukuda, Izumi OSHIMA, Naoto Ishikawa, Yukio KANAI,
Experiment was designed to determine whether heat stress suppresses neutrophil function and injections of selenium and vitamin E prior to heat stress prevent suppression of neutrophil function in goats. Twelve female goats were divided into 2 groups of 6 each and were kept at 25°C. Goats in the treatment group were injected intramuscularly with 0.1 mg/kg of selenium and 2.72 IU/kg of vitamin E at 8 and 1 day prior to the initiation of heat stress. The other group was kept as control. All goats were ...
Tópico(s): Forensic Entomology and Diptera Studies
1998 - Japanese Society of Veterinary Science | Journal of Veterinary Medical Science
Kengo Okada, Kouhei Kasagi, Naoto Oshima, Safumi Suzuki, Masahiro Asada,
In this paper, we proposed and fabricated resonant-tunneling-diode (RTD) terahertz oscillators integrated with slot-fed patch antennas to extract output power without using typical Si lenses. A square patch antenna with a 170 μm-long side was fabricated on a 7 μm-thick benzocyclobutene (BCB) layer stacked on an RTD with a slot resonator. The RTD oscillated at ~ 510 GHz, and an output power of ~ 40 μW radiated in the upward direction without the Si lens. An equivalent circuit model was proposed to estimate ...
Tópico(s): Semiconductor Quantum Structures and Devices
2015 - IEEE Microwave Theory and Techniques Society | IEEE Transactions on Terahertz Science and Technology
Naoto Oshima, Keisuke Hashimoto, Safumi Suzuki, Masahiro Asada,
A resonant-tunnelling-diode terahertz oscillator capable of wide-band direct modulation was fabricated, and wireless data transmission at a 500-GHz range was demonstrated. An error-free transmission up to the data rate of 22 Gbit/s and a transmission with a bit error rate less than the forward error correction limit up to 34 Gbit/s were achieved.
Tópico(s): Terahertz technology and applications
2016 - Institution of Engineering and Technology | Electronics Letters
Naoto Oshima, Kazuhide Hashimoto, Safumi Suzuki, Masahiro Asada,
High-capacity short-distance wireless communications in the terahertz (THz) range are anticipated and therefore have been intensively studied. Higher data rates are made possible by the introduction of frequency division multiplexing (FDM) and polarization division multiplexing (PDM) schemes in the THz range. In this paper, wireless data transmissions using 2-channel FDM in the 500 and 800 GHz ranges and PDM in the 500 GHz range are demonstrated using resonant-tunneling-diode oscillators with different ...
Tópico(s): Superconducting and THz Device Technology
2017 - IEEE Microwave Theory and Techniques Society | IEEE Transactions on Terahertz Science and Technology
M. Tomizawa, Fuminobu Shinozaki, Yoshitaka Uchida, Katsuhiro Uchiyama, Kazunori Fugo, Takafumi Sunaoshi, Aika Ozaki, Eriko Sugiyama, Akira Baba, Yoshiya Fukamizu, Satoshi Kagayama, Rumiko Hasegawa, Yoshinori Shirai, Yuji Oshima, Naoto Koike, Yasuko Toshimitsu, Yasufumi Motoyoshi, Takao Sugiyama, Shigenori Yamamoto, Takashi Kishimoto, Naoki Ishige,
Tópico(s): Medical Imaging Techniques and Applications
2015 - Springer Nature | Abdominal Radiology
Yasuo Kosugi, Michimasa Suzuki, Mitsuhisa Fujimaki, Shinichi Ohba, Fumihiko Matsumoto, Yoichi Muramoto, Terufumi Kawamoto, Masaki Oshima, Naoto Shikama, Keisuke Sasai,
Abstract Objective To determine the most appropriate radiologic criteria of metastatic retropharyngeal lymph nodes (RLNs) in patients with maxillary sinus cancer (MSC). Materials and methods We retrospectively evaluated 16 consecutive patients who underwent magnetic resonance imaging (MRI) before and after the treatment of locally advanced squamous cell carcinoma of the maxillary sinus. The minimal and maximal diameters of all RLNS were recorded. RLNs were classified as metastatic on the basis of the ...
Tópico(s): Sinusitis and nasal conditions
2021 - BioMed Central | Radiation Oncology
Yoshikazu Kinoshita, Taku Hashimoto, Akira Kawamura, Mika Yuki, Kazutoshi Amano, Hironubu Sato, Kyoichi Adachi, Shiori Sato, N Oshima, Toshiharu Takashima, Naoto Kitajima, Kazunori Abe, H. Suetsugu,
Summary Background : An effective therapeutic strategy for functional dyspepsia (FD) has not been well‐established. Aim : We investigated and compared the therapeutic effects of famotidine, mosapride and tandospirone for the control of dyspeptic symptoms. Methods : Fully examined FD patients of outpatient clinics at seven different medical centres were enrolled in the study. They were randomly assigned to three groups based on the type of drug administered: famotidine, mosapride and tandospirone. The effects ...
Tópico(s): Herbal Medicine Research Studies
2005 - Wiley | Alimentary Pharmacology & Therapeutics
Kazuhiro Ohara, Hideaki Unno, Yasuhiro Oshima, Miho Hosoya, Naoto Fujino, Kazutake Hirooka, Seiji Takahashi, Satoshi Yamashita, Masami Kusunoki, Tôru Nakayama,
To investigate the mechanism for low pH adaptation by a carboxylesterase, structural and biochemical analyses of EstFa_R (a recombinant, slightly acidophilic carboxylesterase from Ferroplasma acidiphilum) and SshEstI (an alkaliphilic carboxylesterase from Sulfolobus shibatae DSM5389) were performed. Although a previous proteomics study by another group showed that the enzyme purified from F. acidiphilum contained an iron atom, EstFa_R did not bind to iron as analyzed by inductively coupled plasma ...
Tópico(s): Enzyme function and inhibition
2014 - Elsevier BV | Journal of Biological Chemistry
Hiroshi Tamagawa, Takashi Oshima, Masakatsu Numata, Naoto Yamamoto, Manabu Shiozawa, Soichiro Morinaga, Yuichi Nakamura, Masato Yoshihara, Yuji Sakuma, Y. Kameda, Makoto Akaike, Norio Yukawa, Yasushi Rino, Muneyuki Masuda, Yohei Miyagi,
We evaluated the methylation patterns of histone H3 lysine 27 (H3K27), H3 lysine 36 (H3K36) and the expression of H3K27 methylase EZH2 in patients with colorectal carcinomas with metachronous liver metastasis to search for biomarkers identifying these patients.Double 2-mm core tissue microarrays were made from 54 paraffin-embedded samples of primary colorectal adenocarcinomas and corresponding liver metastases and examined using an immunohistochemical analysis of dimethylation and trimethylation in ...
Tópico(s): RNA modifications and cancer
2013 - Elsevier BV | European Journal of Surgical Oncology
Yukihiro Kaneko, Gen Shinohara, Masato Hoshino, Hiroyuki Morishita, Kiyozo Morita, Yoshihiro Oshima, Masashi Takahashi, Naoto Yagi, Yutaka Okita, Takuro Tsukube,
Structural examination of human heart specimens at the microscopic level is a prerequisite for understanding congenital heart diseases. It is desirable not to destroy or alter the properties of such specimens because of their scarcity. However, many of the currently available imaging techniques either destroy the specimen through sectioning or alter the chemical and mechanical properties of the specimen through staining and contrast agent injection. As a result, subsequent studies may not be possible. ...
Tópico(s): Laser-Plasma Interactions and Diagnostics
2016 - Springer Science+Business Media | Pediatric Cardiology
Takayoshi Oshima, Yuji Katō, Naoto Kawano, Akito Kuramata, Shigenobu Yamakoshi, Shizυo Fujita, Toshiyuki Oishi, Makoto Kasu,
A β-(AlxGa1−x)2O3:Si/Ga2O3 modulation-doped structure was fabricated by direct β-(AlxGa1−x)2O3 epitaxial growth on a (010) β-Ga2O3 substrate. Si on the order of 1018 cm−3 from adsorbed contaminants on the substrate surface was doped into the β-(AlxGa1−x)2O3 layer. The heterojunction interface exhibited a confined sheet carrier density of ∼3 × 1012 cm−2, which is on the same order as that of AlGaAs/GaAs. The successful modulation doping for the β-(AlxGa1−x)2O3/Ga2O3 heterostructure encourages the development ...
Tópico(s): Electronic and Structural Properties of Oxides
2017 - Institute of Physics | Applied Physics Express
Naoya Hara, Akira Isobe, Kana Yamada, Yasuo Kosugi, Masaki Oshima, Terufumi Kawamoto, Naoto Shikama, Keisuke Sasai,
During radiotherapy sessions to treat brain tumors or head-and-neck cancers, some patients experience unusual visual and/or olfactory perceptions. This prospective study sought to answer two questions: (i) what proportion of patients experience these unpleasant sensations?, and (ii) which organs are responsible? Eligible patients had brain or near-orbital tumors treated by helical tomotherapy. All were aged 10 years or older, able to communicate, and interviewed by a radiation oncologist at least ...
Tópico(s): Advanced Chemical Sensor Technologies
2021 - Oxford University Press | Journal of Radiation Research
M. Tomizawa, Fuminobu Shinozaki, Kazunori Fugo, Satomi Tanaka, Takafumi Sunaoshi, Daisuke Kano, Eriko Sugiyama, Misaki Shite, Ryouta Haga, Yoshiya Fukamizu, Toshiyuki Fujita, Satoshi Kagayama, Rumiko Hasegawa, Akira Togawa, Yoshinori Shirai, Noboru Ichiki, Yuji Oshima, Naoto Koike, Yasuko Toshimitsu, Yasufumi Motoyoshi, Takao Sugiyama, Shigenori Yamamoto, Takashi Kishimoto, Naoki Ishige,
Diffusion-weighted whole-body imaging with background body signal suppression (DWIBS) images show significant contrast for cancer tissues against non-cancerous tissues. Fusion of a DWIBS and a T2-weighted image (DWIBS/T2) can be used to obtain functional, as well as anatomic, information. In the present study, the performance of DWIBS/T2 in the diagnosis of abdominal solid cancer was evaluated. The records of 14 patients were retrospectively analyzed [5 patients with hepatocellular carcinoma (HCC), ...
Tópico(s): Advanced Neuroimaging Techniques and Applications
2017 - Spandidos Publishing | Experimental and Therapeutic Medicine
Kouhei Kasagi, Naoto Oshima, Safumi Suzuki, Masahiro Asada,
In this study, we propose and fabricate an oscillator array composed of three resonant-tunneling-diode terahertz oscillators integrated with slot-coupled patch antennas, and which does not require a Si lens. We measure the radiation pattern for single and arrayed oscillator, and calculate the output power using the integration of the pattern. The output power of a single oscillator was found to be ～15 µW. However, using an array configuration, almost combined output power of ～55 µW was obtained.
Tópico(s): Semiconductor Quantum Structures and Devices
2015 - Institute of Electronics, Information and Communication Engineers | IEICE Transactions on Electronics
Yasuhiro Kazuki, Kaoru Kobayashi, Sasitorn Aueviriyavit, Takeshi Oshima, Yoshimi Kuroiwa, Yasuko Tsukazaki, Naoto Senda, Hiroki Kawakami, Sumio Ohtsuki, Satoshi Abe, Masato Takiguchi, Hidetoshi Hoshiya, Naoyo Kajitani, Shoko Takehara, Kin‐ya Kubo, Tetsuya Terasaki, Kan Chiba, Kazuma Tomizuka, Mitsuo Oshimura,
Human CYP3A is the most abundant P450 isozyme present in the human liver and small intestine, and metabolizes around 50% of medical drugs on the market. The human CYP3A subfamily comprises four members (CYP3A4, CYP3A5, CYP3A7, CYP3A43) encoded on human chromosome 7. However, transgenic mouse lines carrying the entire human CYP3A cluster have not been constructed because of limitations in conventional cloning techniques. Here, we show that the introduction of a human artificial chromosome (HAC) containing ...
Tópico(s): Epigenetics and DNA Methylation
2012 - Oxford University Press | Human Molecular Genetics
Ryuji Oshima, Takafumi Hasegawa, Keiichi Tamai, Naoto Sugeno, Shun Yoshida, Junpei Kobayashi, Akio Kikuchi, Toru Baba, Akira Futatsugi, Ikuro Sato, Kennichi Satoh, Atsushi Takeda, Masashi Aoki, Nobuyuki Tanaka,
Abstract Endosomal sorting required for transport (ESCRT) complexes orchestrate endo-lysosomal sorting of ubiquitinated proteins, multivesicular body formation and autophagic degradation. Defects in the ESCRT pathway have been implicated in many neurodegenerative diseases, but the underlying molecular mechanisms that link them to neurodegeneration remain unknown. In this study, we showed that forebrain-specific ablation of ESCRT-0/Hrs induced marked hippocampal neuronal cell loss accompanied by the ...
Tópico(s): Autophagy in Disease and Therapy
2016 - Nature Portfolio | Scientific Reports
Akio Hasegawa, Naoto Miwa, Tairo Oshima, Kazutomo Imahori,
... on: Oxford Academic PubMed Google Scholar Naoto MIWA, Naoto MIWA Department of Agricultural Chemistry, Faculty of Agriculture, the University of TokyoBunkyo-ku, Tokyo 113 Search for other works by this author on: Oxford Academic PubMed Google Scholar Tairo OSHIMA, Tairo OSHIMA Department of Agricultural Chemistry, Faculty of ...
Tópico(s): Biofuel production and bioconversion
1976 - Oxford University Press | The Journal of Biochemistry
Yoshiaki Oshima, Yuichi Ishibe, Naoto OKAZAKI, Tôru Satô,
The role of volatile anaesthetics on nitric oxide (NO)-dependent relaxation is unclear in the pulmonary circulation. We examined the effects of isoflurane on NO-dependent relaxation in isolated perfused rabbit lungs.Eighteen rabbit lungs were perfused in a constant-flow recirculation manner. In study 1 (n = 12), acetylcholine (ACh, 4 x 10(-10)-10(-8) M) or nitroglycerine (NTG, 6 x 10(-10)-10(-8) M) was cumulatively injected into the pulmonary artery in the absence or presence of isoflurane (1, 2 MAC). ...
Tópico(s): Respiratory Support and Mechanisms
1997 - Springer Science+Business Media | Canadian Journal of Anesthesia/Journal canadien d anesthésie
Takanobu Inada, Hitoshi Sato, Yoshinori Hayashi, Suzuro Hitomi, Akihiko Furukawa, Masatoshi Ando, Eri Oshima, Jo Otsuji, Naoto Taguchi, Ikuko Shibuta, Hiromasa Tsuda, Koichi Iwata, Tatsuo Shirota, Masamichi Shinoda,
Sensory disturbance in the orofacial region owing to trigeminal nerve injury is caused by dental treatment or accident. Commercially available therapeutics are ineffective for the treatment of sensory disturbance. Additionally, the therapeutic effects of rapamycin, an allosteric inhibitor of mammalian target of rapamycin (mTOR), which negatively regulates autophagy, on the sensory disturbance are not fully investigated. Thus, we investigated the therapeutic effects of rapamycin on the sensory disturbance ...
Tópico(s): Autophagy in Disease and Therapy
2021 - Elsevier BV | Neuroscience
Tsutomu Sato, Toru Aoyama, Tsutomu Hayashi, Kenki Segami, Taiichi Kawabe, Hirohito Fujikawa, Takanobu Yamada, Naoto Yamamoto, Takashi Oshima, Yasushi Rino, Munetaka Masuda, Takashi Ogata, Haruhiko Cho, Takaki Yoshikawa,
Sarcopenia is a decrease in both muscle mass and strength. It remains unclear whether sarcopenia is associated with morbidity after gastric cancer surgery. This study evaluated the impact of sarcopenia on the morbidity of gastric cancer surgery.A total of 293 gastric cancer patients who underwent curative surgery between May 2011 and June 2013 were retrospectively examined. Patients with performance status 3 or 4 were excluded. Preoperative lean body mass (LBM) was evaluated by bioelectrical impedance ...
Tópico(s): Stoma care and complications
2015 - Springer Science+Business Media | Gastric Cancer
Akio Kikuchi, Nobuyuki Okamura, Takafumi Hasegawa, Ryuichi Harada, S. Watanuki, Yoshihito Funaki, Kotaro Hiraoka, Toru Baba, Naoto Sugeno, Ryuji Oshima, Shun Yoshida, Junpei Kobayashi, Michinori Ezura, Michiko Kobayashi, Ohito Tano, Shunji Mugikura, Ren Iwata, Aiko Ishiki, Katsutoshi Furukawa, Hiroyuki Arai, Shozo Furumoto, Manabu Tashiro, Kazuhiko Yanai, Yukitsuka Kudo, Atsushi Takeda, Masashi Aoki,
To determine whether 18F-THK5351 PET can be used to visualize tau deposits in brain lesions in live patients with corticobasal syndrome (CBS).We evaluated the in vitro binding of 3H-THK5351 in postmortem brain tissues from a patient with corticobasal degeneration (CBD). In clinical PET studies, 18F-THK5351 retention in 5 patients with CBS was compared to that in 8 age-matched normal controls and 8 patients with Alzheimer disease (AD).3H-THK5351 was able to bind to tau deposits in the postmortem brain ...
Tópico(s): Advanced Neuroimaging Techniques and Applications
2016 - Lippincott Williams & Wilkins | Neurology
Naoto Yamamoto, Takashi Oshima, Kazue Yoshihara, Toru Aoyama, Tsutomu Hayashi, Takanobu Yamada, Tsutomu Sato, Manabu Shiozawa, Takaki Yoshikawa, Soichiro Morinaga, Yasushi Rino, Chikara Kunisaki, Katsuaki Tanaka, Makoto Akaike, Toshio Imada, Munetaka Masuda,
The insulin‑like growth factors (IGF) system is involved in tumor proliferation, invasion and metastasis in cancer. The current study investigated the association of IGF‑1, IGF‑2 and IGF‑1 receptor (IGF‑1R), IGF binding proteins type 3 (IGFBP‑3) mRNA expression levels with clinicopathological characteristics and outcomes of 202 patients with untreated colorectal cancer (CRC). IGF‑1, IGF‑2, IGF‑1R and IGFBP‑3 mRNA expression levels were analyzed in surgical specimens of cancer tissues and adjacent normal ...
Tópico(s): Genetic factors in colorectal cancer
2017 - Spandidos Publishing | Oncology Letters
Yukihiko Hiroshima, Rika Kasajima, Yayoi Kimura, Daisuke Komura, Shumpei Ishikawa, Yasushi Ichikawa, Michael Bouvet, Naoto Yamamoto, Takashi Oshima, Soichiro Morinaga, Shree Ram Singh, Robert M. Hoffman, Itaru Endo, Yohei Miyagi,
The pancreatic cancer microenvironment is crucial in cancer development, progression and drug resistance. Cancer-stromal interactions have been recognized as important targets for cancer therapy. However, identifying relevant and druggable cancer-stromal interactions is challenging due to the lack of quantitative methods to analyze the whole cancer-stromal interactome. Here we studied 14 resected pancreatic cancer specimens (8 pancreatic adenocarcinoma (PDAC) patients as a cancer group and 6 intraductal ...
Tópico(s): Ferroptosis and cancer prognosis
2019 - Elsevier BV | Cancer Letters
Michinori Ezura, Akio Kikuchi, Aiko Ishiki, Nobuyuki Okamura, Takafumi Hasegawa, Ryuichi Harada, S. Watanuki, Y. Funaki, Kotaro Hiraoka, Toru Baba, Naoto Sugeno, Ryuji Oshima, Sumiko Yoshida, Junpei Kobayashi, Michiko Kobayashi, Ohito Tano, Ichiro Nakashima, Shunji Mugikura, Ren Iwata, Yasuyuki Taki, Katsutoshi Furukawa, Hiroyuki Arai, Shozo Furumoto, Manabu Tashiro, Kazuhiko Yanai, Yoshihisa Kudo, Atsushi Takeda, Masashi Aoki,
Corticobasal syndrome (CBS) is pathologically characterized by tau deposits in neuronal and glial cells and by reactive astrogliosis. In several neurodegenerative disorders, 18 F-THK5351 has been observed to bind to reactive astrocytes expressing monoamine oxidase B. In this study, the aim was to investigate the progression of disease-related pathology in the brains of patients with CBS using positron emission tomography with 18 F-THK5351.Baseline and 1-year follow-up imaging were acquired using ...
Tópico(s): Alzheimer's disease research and treatments
2019 - Wiley | European Journal of Neurology
Naoto Yamamoto, Takashi Oshima, Tsutomu Sato, Hirochika Makino, Yasuhiko Nagano, Shoichi Fujii, Yasushi Rino, Toshio Imada, Chikara Kunisaki,
Postoperative pancreas fistula (POPF) is a major complication after total gastrectomy with splenectomy. We retrospectively studied the effects of upper abdominal shape on the development of POPF after gastrectomy. Fifty patients who underwent total gastrectomy with splenectomy were studied. The maximum vertical distance measured by computed tomography (CT) between the anterior abdominal skin and the back skin (U-APD) and the maximum horizontal distance of a plane at a right angle to U-APD (U-TD) were ...
Tópico(s): Pancreatic and Hepatic Oncology Research
2008 - BioMed Central | World Journal of Surgical Oncology
Takashi Oshima, Chikara Kunisaki, Kazue Yoshihara, Roppei Yamada, Naoto Yamamoto, Tsutomu Sato, Hirochika Makino, Shigeru Yamagishi, Yasuhiko Nagano, Shoich Fujii, Manabu Shiozawa, Makoto Akaike, Nobuyuki Wada, Yasushi Rino, Munetaka Masuda, Katsuaki Tanaka, Toshio Imada,
Matrix metalloproteinase-2 (MMP-2), matrix metalloproteinase-9 (MMP-9) and membrane-type matrix metalloproteinase 1 (MT1-MMP) are involved in colorectal cancer invasion and metastasis. Reversion-inducing cysteine-rich protein with Kazal motifs (RECK) inhibits MMP-2, MMP-9 and MT1-MMP. We examined the clinicopathological significance of the relative expression of these genes in patients with colorectal cancer, especially with regard to metastasis. We studied surgical specimens of cancer tissue and adjacent ...
Tópico(s): Bone health and treatments
2008 - Elsevier BV | Oncology Reports
Takashi Oshima, Chikara Kunisaki, Kazue Yoshihara, Roppei Yamada, Naoto Yamamoto, Tsutomu Sato, Hirochika Makino, Shigeru Yamagishi, Yasuhiko Nagano, Shoich Fujii, Manabu Shiozawa, Makoto Akaike, Nobuyuki Wada, Yasushi Rino, Munetaka Masuda, Katsuaki Tanaka, Toshio Imada,
Claudins, members of a large family of adherent junction proteins, regulate the integrity and function of tight junctions and influence tumorigenesis. Studies have suggested that altered levels of different claudins are related to carcinoma-cell invasion and disease progression. This study examined the relationship between the relative expression of claudin genes and clinicopathological factors, especially invasion and metastasis, in patients with colorectal cancer. We studied surgical specimens ...
Tópico(s): MRI in cancer diagnosis
2008 - Elsevier BV | Oncology Reports