Hendrik Gille, Joe Kowalski, Lanlan Yu, Helen Chen, M. Teresa Pisabarro, Terri Davis-Smyth, Napoleone Ferrara,
... USA Search for more papers by this author Napoleone Ferrara Corresponding Author Napoleone Ferrara Departments of Molecular Oncology, South San Francisco, CA, ... USA Search for more papers by this author Napoleone Ferrara Corresponding Author Napoleone Ferrara Departments of Molecular Oncology, South San Francisco, CA, ... Chen1, M.Teresa Pisabarro3, Terri Davis-Smyth4 and Napoleone Ferrara 1 1Departments of Molecular Oncology, South San Francisco, ...
Tópico(s): Protease and Inhibitor Mechanisms
2000 - Springer Nature | The EMBO Journal
Jianying Dong, Jeremy Grunstein, Max L. Tejada, Frank Peale, Gretchen Frantz, Wei‐Ching Liang, Wei Bai, Lanlan Yu, Joe Kowalski, Xiao‐Huan Liang, Germaine Fuh, Hans‐Peter Gerber, Napoleone Ferrara,
... USA Search for more papers by this author Napoleone Ferrara Corresponding Author Napoleone Ferrara Department of Molecular Oncology, Genentech Inc., South San ... USA Search for more papers by this author Napoleone Ferrara Corresponding Author Napoleone Ferrara Department of Molecular Oncology, Genentech Inc., South San ... Xiaohuan Liang1, Germaine Fuh3, Hans-Peter Gerber1 and Napoleone Ferrara 1 1Department of Molecular Oncology, Genentech Inc., South ...
Tópico(s): Cancer Research and Treatments
2004 - Springer Nature | The EMBO Journal
Pin Li, Qin Li, Nilima Biswas, Hong Xin, Tanja Diemer, Lixian Liu, Lorena Pérez, Giovanni Paternostro, Carlo Piermarocchi, Sergii Domanskyi, Ruikang K. Wang, Napoleone Ferrara,
... USA Search for more papers by this author Napoleone Ferrara Corresponding Author Napoleone Ferrara [email protected] orcid.org/0000-0002-7029-6375 ... USA Search for more papers by this author Napoleone Ferrara Corresponding Author Napoleone Ferrara [email protected] orcid.org/0000-0002-7029-6375 ... Carlo Piermarocchi4, Sergii Domanskyi4, Ruikang K Wang5 and Napoleone Ferrara *,1,2 1Department of Pathology, University of California ...
Tópico(s): Neutrophil, Myeloperoxidase and Oxidative Mechanisms
2021 - Springer Nature | EMBO Molecular Medicine
Napoleone Ferrara, Henry Heinsohn, Claire E. Walder, Stuart Bunting, Glyn Thomas,
... Blood Vessel Growth by Vascular Endothelial Growth Factor NAPOLEONE FERRARA, Corresponding Author NAPOLEONE FERRARA Departments of Cardiovascular Research, 460 Point Sun Bruno ... California 94080Search for more papers by this author NAPOLEONE FERRARA, Corresponding Author NAPOLEONE FERRARA Departments of Cardiovascular Research, 460 Point Sun Bruno ...
Tópico(s): Congenital heart defects research
1995 - Wiley | Annals of the New York Academy of Sciences
... s Lasker DeBakey Clinical Research Award goes to Napoleone Ferrara for the discovery of vascular endothelial growth factor ( ... s Lasker DeBakey Clinical Research Award goes to Napoleone Ferrara for the discovery of vascular endothelial growth factor ( ... development of an effective new class of therapeutics. Napoleone Ferrara, recipient of this year's Lasker DeBakey Clinical ...
Tópico(s): Venous Thromboembolism Diagnosis and Management
2010 - Cell Press | Cell
Napoleone Ferrara and his colleagues at Genentech were the first to isolate and clone vascular endothelial growth factor ( ...
Tópico(s): Angiogenesis and VEGF in Cancer
2011 - University of the Basque Country | The International Journal of Developmental Biology
Napoleone Ferrara and his colleagues at Genentech were the first to isolate and clone vascular endothelial growth factor ( ...
Tópico(s): PI3K/AKT/mTOR signaling in cancer
2008 - Taylor & Francis | Endothelium
Jennifer LeCouter, Joe Kowalski, Jessica Foster, Phil Hass, Zemin Zhang, Lisa Dillard‐Telm, Gretchen Frantz, Linda Rangell, Leo Deguzman, Gilbert-André Keller, Franklin Peale, Austin Gurney, Kenneth J. Hillan, Napoleone Ferrara,
... Andre; Peale, Franklin; Gurney, Austin; Hillan, Kenneth J.; Ferrara, Napoleone
Tópico(s): Angiogenesis and VEGF in Cancer
2002 - Lippincott Williams & Wilkins | Obstetrical & Gynecological Survey
Jenny Yao, Xiumin Wu, Guanglei Zhuang, Ian Kasman, Tobias Vogt, Vernon T. Phan, Masabumi Shibuya, Napoleone Ferrara, Carlos Bais,
PlGF, one of the ligands for VEGFR-1, has been implicated in tumor angiogenesis. However, more recent studies indicate that genetic or pharmacological inhibition of PlGF signaling does not result in reduction of microvascular density in a variety of tumor models. Here we screened 12 human tumor cell lines and identified 3 that are growth inhibited by anti-PlGF antibodies in vivo. We found that efficacy of anti-PlGF treatment strongly correlates with VEGFR-1 expression in tumor cells, but not with ...
Tópico(s): Cancer, Hypoxia, and Metabolism
2011 - National Academy of Sciences | Proceedings of the National Academy of Sciences
Michal Milgrom-Hoffman, Zachary Harrelson, Napoleone Ferrara, Elazar Zelzer, Sylvia Μ. Evans, Eldad Tzahor,
The embryonic heart is composed of two cell layers: the myocardium, which contributes to cardiac muscle tissue, and the endocardium, which covers the inner lumen of the heart. Whereas significant progress has been made toward elucidating the embryonic origins of the myocardium, the origins of the endocardium remain unclear. Here, we have identified an endocardium-forming field medial to the cardiac crescent, in a continuum with the endothelial plexus. In vivo live imaging of quail embryos revealed ...
Tópico(s): Wind Turbine Control Systems
2011 - The Company of Biologists | Development
Claire E. Lewis, Napoleone Ferrara,
Tópico(s): Cancer, Hypoxia, and Metabolism
2011 - Cell Press | Cancer Cell
Alicia S. Chung, Napoleone Ferrara,
The formation of the vascular network is an intricate and complex process that is an obligate requirement during vertebrate development. The cardiovascular system is the first organ to develop and reach a functional state, which underscores the crucial role of the vasculature in the developing embryo. The development of the vasculature into highly branched conduits needs to occur in numerous sites and in precise patterns to supply oxygen and nutrients to the rapidly expanding tissue of the embryo. ...
Tópico(s): Cancer, Hypoxia, and Metabolism
2011 - Annual Reviews | Annual Review of Cell and Developmental Biology
James A. Stefater, Ian Lewkowich, Sujata Rao, Giovanni Mariggi, April C. Carpenter, A. Burr, Jieqing Fan, Rieko Ajima, Jeffery D. Molkentin, Bart O. Williams, Marsha Wills‐Karp, Jeffrey W. Pollard, Terry P. Yamaguchi, Napoleone Ferrara, Holger Gerhardt, Richard A. Lang,
Richard Lang and colleagues identify a mechanism by which myeloid cells regulate the pattern of blood-vessel branching in the post-natal retina. They show that macrophages inhibit branching by secreting Wnt ligands that use a non-canonical pathway to induce secretion of the VEGF inhibitory receptor Flt1. Myeloid cells are a feature of most tissues. Here we show that during development, retinal myeloid cells (RMCs) produce Wnt ligands to regulate blood vessel branching. In the mouse retina, where ...
Tópico(s): Axon Guidance and Neuronal Signaling
2011 - Nature Portfolio | Nature
Max L. Tejada, Lanlan Yu, Jianying Dong, Kenneth Jung, Gloria Meng, Franklin Peale, Gretchen Frantz, Linda Hall, Xiao‐Huan Liang, Hans‐Peter Gerber, Napoleone Ferrara,
Activated fibroblasts are thought to play important roles in the progression of many solid tumors, but little is known about the mechanisms responsible for the recruitment of fibroblasts in tumors. Using several methods, we identified platelet-derived growth factor A (PDGFA) as the major fibroblast chemoattractant and mitogen from conditioned medium generated by the Calu-6 lung carcinoma cell line. In addition, we showed that Calu-6 tumors express significant levels of PDGFC, and that the levels ...
Tópico(s): Cancer, Hypoxia, and Metabolism
2006 - American Association for Cancer Research | Clinical Cancer Research
Wei‐Ching Liang, Mark S. Dennis, Scott Stawicki, Yvan H. Chanthery, Qi Pan, Yongmei Chen, Charles Eigenbrot, Jianping Yin, Alexander Koch, Xiumin Wu, Napoleone Ferrara, Anil Bagri, Marc Tessier‐Lavigne, Ryan J. Watts, Yan Wu,
Non-immune (naïve) antibody phage libraries have become an important source of human antibodies. The synthetic phage antibody library described here utilizes a single human framework with a template containing human consensus complementarity-determining regions (CDRs). Diversity of the libraries was introduced at select CDR positions using tailored degenerate and trinucleotide codons that mimic natural human antibodies. Neuropilin-1 (NRP1), a cell-surface receptor for both vascular endothelial growth ...
Tópico(s): Glycosylation and Glycoproteins Research
2006 - Elsevier BV | Journal of Molecular Biology
Napoleone Ferrara, R. Mass, Claudio Campa, Robert Kim,
Inhibiting angiogenesis is a promising strategy to treat cancer and several other disorders, including intraocular neovascular syndromes. The identification of vascular endothelial growth factor (VEGF)-A as a major regulator of normal and pathological angiogenesis has enabled significant progress toward effective treatments for such disorders. Several VEGF inhibitors have been recently approved by the U.S. Food and Drug Administration for the treatment of cancer and the neovascular form of age-related ...
Tópico(s): Retinoids in leukemia and cellular processes
2006 - Annual Reviews | Annual Review of Medicine
Napoleone Ferrara, Lisa A. Damico, Naveed Shams, Henry B. Lowman, Robert Kim,
In Brief Background: Angiogenesis is a key aspect of the wet form of age-related neovascular (AMD), the leading cause of blindness in the elderly population. Substantial evidence indicated that vascular endothelial growth factor (VEGF)-A is a major mediator of angiogenesis and vascular leakage in wet AMD. VEGF-A is the prototype member of a gene family that includes also PlGF, VEGF-B, VEGF-C, VEGF-D and the orf virus-encoded VEGF-E. Several isoforms of VEGF-A can be generated due to alternative mRNA ...
Tópico(s): Retinal Development and Disorders
2006 - Lippincott Williams & Wilkins | Retina
K. Red-Horse, Napoleone Ferrara,
Since the discovery of vascular-specific growth factors with angiogenic activity, there has been a significant effort to develop cancer drugs that restrict tumorigenesis by targeting the blood supply. In this issue of the JCI, Mancuso et al. use mouse models to better understand the plasticity of the tumor vasculature in the face of antiangiogenic therapy (see the related article beginning on page 2610). They describe a rapid regrowth of the tumor vasculature following withdrawal of VEGFR inhibitors, ...
Tópico(s): Cell Adhesion Molecules Research
2006 - American Society for Clinical Investigation | Journal of Clinical Investigation
Ganka Nikolova, Normund Jabs, Irena Konstantinova, Anna Domogatskaya, Karl Tryggvason, Lydia Sorokin, Reinhard Fässler, Guoqiang Gu, Hans‐Peter Gerber, Napoleone Ferrara, Douglas A. Melton, Eckhard Lammert,
Tópico(s): Diabetes and associated disorders
2006 - Elsevier BV | Developmental Cell
Marcin Kowanetz, Napoleone Ferrara,
Abstract The establishment of a vascular supply is one of the earliest and most important events occurring during embryonic development. Growth and maturation of a functional vascular network are complex and still incompletely understood processes involving orchestrated activation of vascular progenitors in the early stages of embryonic development followed by vasculogenesis and angiogenesis. These processes require a tightly regulated activation of several growth factors and their receptors. The ...
Tópico(s): Biomarkers in Disease Mechanisms
2006 - American Association for Cancer Research | Clinical Cancer Research
Balamurali K. Ambati, Miho Nozaki, Nirbhai Singh, Atsunobu Takeda, Pooja D. Jani, Tushar Suthar, Romulo Albuquerque, Elizabeth R. Richter, Eiji Sakurai, Michael T. Newcomb, Mark E. Kleinman, Ruth B. Caldwell, Qing Lin, Yuichiro Ogura, Angela Orecchia, Don A. Samuelson, Dalen Agnew, Judy St. Leger, W. Richard Green, Parameshwar J. Mahasreshti, David T. Curiel, Donna Kwan, Helene Marsh, Sakae Ikeda, Lucy J. Leiper, J. Martin Collinson, Sasha Bogdanovich, Tejvir S. Khurana, Masabumi Shibuya, Megan E. Baldwin, Napoleone Ferrara, Hans-Peter Gerber, Sandro De Falco, Jassir Witta, Judit Baffi, Brian J. Raisler, Jayakrishna Ambati,
Corneal avascularity-the absence of blood vessels in the cornea-is required for optical clarity and optimal vision, and has led to the cornea being widely used for validating pro- and anti-angiogenic therapeutic strategies for many disorders. But the molecular underpinnings of the avascular phenotype have until now remained obscure and are all the more remarkable given the presence in the cornea of vascular endothelial growth factor (VEGF)-A, a potent stimulator of angiogenesis, and the proximity ...
Tópico(s): Corneal surgery and disorders
2006 - Nature Portfolio | Nature
N. Iwashita, Toyoyoshi Uchida, Jong Bock Choi, Kosuke Azuma, Takeshi Ogihara, Napoleone Ferrara, Hans‐Peter Gerber, Ryuzo Kawamori, M Inoue, Hirotaka Watada,
Endothelial cells are considered to be essential for normal pancreatic beta cell function. However, there have been no reports showing their importance for beta cell function. Using mice with disrupted vascular endothelial growth factor-A gene specifically in beta cells, we investigated the relation between islet vascular structure and beta cell function. Mice with disrupted vascular endothelial growth factor-A gene specifically in beta cells had reduced islet vascular density with impaired formation ...
Tópico(s): Diabetes Treatment and Management
2006 - Springer Science+Business Media | Diabetologia
Vera Eremina, Shiying Cui, Hans‐Peter Gerber, Napoleone Ferrara, Jody J. Haigh, András Nagy, Masatsugu Ema, Janet Rossant, Serge Jothy, Jeffrey H. Miner, Susan E. Quaggin,
The glomerular filtration barrier separates the blood from the urinary space and consists of two major cell types: podocytes and fenestrated endothelial cells. Mesangial cells sit between the capillary loops and provide structural support. Proliferation and loss of mesangial cells both are central findings in a number of renal diseases, including diabetic nephropathy and mesangiolysis, respectively. Using cell-specific gene targeting, it was shown previously that vascular endothelial growth factor ...
Tópico(s): Angiogenesis and VEGF in Cancer
2006 - American Society of Nephrology | Journal of the American Society of Nephrology
Azeb Tadesse Argaw, Linnéa Asp, Jingya Zhang, Kristina Navrazhina, Trinh Pham, John N. Mariani, Sean S. Mahase, Dipankar J. Dutta, Jeremy Seto, Elisabeth G. Kramer, Napoleone Ferrara, Michael V. Sofroniew, Gareth John,
In inflammatory CNS conditions such as multiple sclerosis (MS), current options to treat clinical relapse are limited, and more selective agents are needed. Disruption of the blood-brain barrier (BBB) is an early feature of lesion formation that correlates with clinical exacerbation, leading to edema, excitotoxicity, and entry of serum proteins and inflammatory cells. Here, we identify astrocytic expression of VEGF-A as a key driver of BBB permeability in mice. Inactivation of astrocytic Vegfa expression ...
Tópico(s): Cell Adhesion Molecules Research
2012 - American Society for Clinical Investigation | Journal of Clinical Investigation
Jing Jin, Karen Sison, Chengjin Li, Ruijun Tian, Monika Wnuk, Hoon‐Ki Sung, Marie Jeansson, Cunjie Zhang, Monika Tucholska, Nina Jones, Dontscho Kerjaschki, Masabumi Shibuya, I. George Fantus, András Nagy, Hans-Peter Gerber, Napoleone Ferrara, Tony Pawson, Susan E. Quaggin,
SummaryVascular endothelial growth factor and its receptors, FLK1/KDR and FLT1, are key regulators of angiogenesis. Unlike FLK1/KDR, the role of FLT1 has remained elusive. FLT1 is produced as soluble (sFLT1) and full-length isoforms. Here, we show that pericytes from multiple tissues produce sFLT1. To define the biologic role of sFLT1, we chose the glomerular microvasculature as a model system. Deletion of Flt1 from specialized glomerular pericytes, known as podocytes, causes reorganization of their ...
Tópico(s): Chronic Kidney Disease and Diabetes
2012 - Cell Press | Cell
Sebastian Willenborg, Tina Lucas, Geert Loo, Johanna A. Knipper, Thomas Krieg, Ingo Haase, Bent Brachvogel, Matthias Hammerschmidt, András Nagy, Napoleone Ferrara, Manolis Pasparakis, Sabine A. Eming,
Abstract Monocytes/macrophages are critical in orchestrating the tissue-repair response. However, the mechanisms that govern macrophage regenerative activities during the sequential phases of repair are largely unknown. In the present study, we examined the dynamics and functions of diverse monocyte/macrophage phenotypes during the sequential stages of skin repair. By combining the analysis of a new CCR2-eGFP reporter mouse model with conditional mouse mutants defective in myeloid cell–restricted ...
Tópico(s): Mesenchymal stem cell research
2012 - Elsevier BV | Blood
Joan W. Miller, Jennifer Le Couter, Erich C. Strauss, Napoleone Ferrara,
The vascular beds supplying the retina may sustain injury as a result of underlying disease such as diabetes, and/or the interaction of genetic predisposition, environmental insults, and age. The vascular pathologic features observed in different intraocular vascular diseases can be categorized broadly as proliferation, exemplified by proliferative diabetic retinopathy, leakage such as macular edema secondary to retinal vein occlusion, or a combination of proliferation and leakage, as seen in neovascular ...
Tópico(s): Retinal Imaging and Analysis
2012 - Elsevier BV | Ophthalmology
Yanqiu Liu, Agnes D. Berendsen, Shidong Jia, Sutada Lotinun, Roland Baron, Napoleone Ferrara, Bjørn R. Olsen,
Osteoporotic bones have reduced spongy bone mass, altered bone architecture, and increased marrow fat. Bone marrow stem cells from osteoporotic patients are more likely to differentiate into adipocytes than control cells, suggesting that adipocyte differentiation may play a role in osteoporosis. VEGF is highly expressed in osteoblastic precursor cells and is known to stimulate bone formation. Here we tested the hypothesis that VEGF is also an important regulator of cell fate, determining whether ...
Tópico(s): Mesenchymal stem cell research
2012 - American Society for Clinical Investigation | Journal of Clinical Investigation
Guanglei Zhuang, Xiumin Wu, Zhaoshi Jiang, Ian Kasman, Jenny Yao, Yinghui Guan, Jason Oeh, Zora Modrušan, Carlos Bais, Deepak Sampath, Napoleone Ferrara,
Angiogenesis plays a crucial role during tumorigenesis and much progress has been recently made in elucidating the role of VEGF and other growth factors in the regulation of angiogenesis. Recently, microRNAs (miRNAs) have been shown to modulate a variety of physiogical and pathological processes. We identified a set of differentially expressed miRNAs in microvascular endothelial cells co-cultured with tumour cells. Unexpectedly, most miRNAs were derived from tumour cells, packaged into microvesicles ( ...
Tópico(s): Cytokine Signaling Pathways and Interactions
2012 - Springer Nature | The EMBO Journal
Ferdinando Nicoletti, Francesco Patti, Napoleone Ferrara, Pier Luigi Canonico, G. Giammona, D. F. Condorelli, U. Scapagnini,
The comparative effects of a 10 day estrogen treatment and estrogen independent hyperprolactinemia on nigral and striatal glutamic acid decarboxylase (GAD, EC 4.1.1.15) activity were investigated in male rats. Data obtained show that estrogen treatment decreases GAD activity in substantia nigra, while an increase was observed in conditions of hyperprolactinemia induced by adenohypophysis homograft or acute and chronic sulpiride injection. The possibility of an opposite modulation of strio-nigral ...
Tópico(s): Growth Hormone and Insulin-like Growth Factors
1982 - Elsevier BV | Brain Research