Ji Youn Lee, Nazgul Tuleuova, Caroline N. Jones, Erlan Ramanculov, Mark Α. Zern, Alexander Revzin,
... by this author on: Oxford Academic Google Scholar Nazgul Tuleuova, Nazgul Tuleuova Department of Biomedical Engineering, University of California, ...
Tópico(s): Viral Infectious Diseases and Gene Expression in Insects
2009 - Oxford University Press | Integrative Biology
J. Michael Burgess, Ewan Cameron, D. Svinkin, J. Greiner,
... made publicly available here (https://github.com/grburgess/nazgul) for the purpose of replication.
Tópico(s): Stellar, planetary, and galactic studies
2021 - EDP Sciences | Astronomy and Astrophysics
Roxane de la Sablonnière, Donald M. Taylor, Nazgul Sadykova,
The challenge of maximizing student learning has been paramount in many societies. This issue has become especially salient in the context of drastic social and political changes that have taken place in countries such as Kyrgyzstan. Since the collapse of the Soviet Union, teachers and students are confronted with new ways of thinking, which are challenging their understanding of how to promote efficient learning. In this paper, the challenges of applying and developing a new approach to learning, ...
Tópico(s): Innovative Teaching Methodologies in Social Sciences
2009 - Elsevier BV | International Journal of Educational Development
Caroline N. Jones, Nazgul Tuleuova, Ji Youn Lee, Erlan Ramanculov, A. Hari Reddi, Mark Α. Zern, Alexander Revzin,
Growth factors are commonly present in soluble form during in vitro cell cultivation experiments in order to provide signals for cellular proliferation or differentiation. In contrast to these traditional experiments, we investigated solid-phase presentation of a hepatocyte growth factor (HGF), a protein important in liver development and regeneration, on microarrays of extracellular matrix (ECM) proteins. In our experiments, HGF was mixed in solution with ECM proteins (collagen (I), (IV) or laminin) ...
Tópico(s): Viral Infectious Diseases and Gene Expression in Insects
2009 - Elsevier BV | Biomaterials
Nazgul Jenish, Ingmar R. Prucha,
Over the last decades, spatial-interaction models have been increasingly used in economics. However, the development of a sufficiently general asymptotic theory for nonlinear spatial models has been hampered by a lack of relevant central limit theorems (CLTs), uniform laws of large numbers (ULLNs) and pointwise laws of large numbers (LLNs). These limit theorems form the essential building blocks towards developing the asymptotic theory of M-estimators, including maximum likelihood and generalized method ...
Tópico(s): Economics of Agriculture and Food Markets
2009 - Elsevier BV | Journal of Econometrics
Sunny S. Shah, Ji Youn Lee, Stanislav V. Verkhoturov, Nazgul Tuleuova, E. A. Schweikert, Erlan Ramanculov, Alexander Revzin,
This paper describes a novel approach of controlling cell-surface interactions through an electrochemical "switching" of biointerfacial properties of optically transparent microelectrodes. The indium tin oxide (ITO) microelectrodes, fabricated on glass substrates, were modified with poly(ethylene glycol) (PEG) silane to make glass and ITO regions resistant to protein and cell adhesion. Cyclic voltammetry, with potassium ferricyanide serving as a redox reporter molecule, was used to monitor electron ...
Tópico(s): Electrochemical Analysis and Applications
2008 - American Chemical Society | Langmuir
Nazgul Tuleuova, Chung-Il An, Erlan Ramanculov, Alexander Revzin, Yohei Yokobayashi,
RNA interference (RNAi) has emerged as a powerful technology to silence arbitrary genes by designing small RNA constructs based on the targeted messenger RNA sequences. We recently developed a small molecule-controlled RNAi gene switch that combined the molecular recognition by in vitro selected RNA aptamers with versatile gene silencing by small interfering RNAs, and demonstrated for the first time, posttranscriptional modulation of RNAi through direct RNA-small molecule interaction. In this report, ...
Tópico(s): RNA Research and Splicing
2008 - Elsevier BV | Biochemical and Biophysical Research Communications
Roxane de la Sablonnière, Donald M. Taylor, Cristina Perozzo, Nazgul Sadykova,
Abstract The present study investigated the relationship between Temporal Collective Relative Deprivation and collective well‐being in the context of dramatic social change in Kyrgyzstan. Traditional research has evaluated Temporal Collective Relative Deprivation by comparing a group's present situation to a point in the recent past or future. We argue that a reconceptualization of Temporal Collective Relative Deprivation is needed. We hypothesized, first, that examining several, as opposed to a ...
Tópico(s): Health disparities and outcomes
2008 - Wiley | European Journal of Social Psychology
Roxane de la Sablonnière, Émilie Auger, Nazgul Sadykova, Donald M. Taylor,
Dramatic social change leads to profound societal transformations in many countries around the world. The two recent revolutions in March 2005 and April 2010, and the ethnic conflict in June 2010 in Kyrgyzstan are vivid examples. The present research aims to understand people’s reactions to dramatic social change in terms of personal well-being. To further understand how people react psychologically to dramatic social change, the theoretical framework of our research is based on a dominant theory ...
Tópico(s): Mental Health Research Topics
2010 - Hogrefe Verlag | European Psychologist
Nazgul Tuleuova, Alexander Revzin,
Aptamer beacons are DNA or RNA probes that bind proteins or small molecules of interest and emit signal directly upon interaction with the target analyte. This paper describes micropatterning of aptamer beacons for detection of IFN-γ-an important inflammatory cytokine. The beacon consisted of a fluorophore-labeled aptamer strand hybridized with a shorter, quencher-carrying complementary strand. Cytokine molecules were expected to displace quenching strands of the beacon, disrupting FRET effect and ...
Tópico(s): Microfluidic and Capillary Electrophoresis Applications
2010 - Springer Science+Business Media | Cellular and Molecular Bioengineering
Ying Liu, Nazgul Tuleouva, Erlan Ramanculov, Alexander Revzin,
In this paper, we describe the development of an electrochemical DNA aptamer-based biosensor for detection of interferon (IFN)-γ. A DNA hairpin containing IFN-γ−binding aptamer was thiolated, conjugated with methylene blue (MB) redox tag, and immobilized on a gold electrode by self-assembly. Binding of IFN-γ caused the aptamer hairpin to unfold, pushing MB redox molecules away from the electrode and decreasing electron-transfer efficiency. The change in redox current was quantified using square wave ...
Tópico(s): RNA and protein synthesis mechanisms
2010 - American Chemical Society | Analytical Chemistry
Caroline N. Jones, Nazgul Tuleuova, Ji Youn Lee, Erlan Ramanculov, A. Hari Reddi, Mark Α. Zern, Alexander Revzin,
The goal of the present study was to investigate hepato-protective effects of growth factor (GF) arrays during alcohol injury. Hepatocyte growth factor (HGF) and bone morphogenetic protein (BMP)7 were mixed with collagen (I) and robotically printed onto standard glass slides to create arrays of 500 μm diameter spots. Primary rat hepatocytes were seeded on top of the arrays forming clusters corresponding in size to the underlying protein spots. Cell arrays were then injured in culture by exposure to ...
Tópico(s): Mesenchymal stem cell research
2010 - Elsevier BV | Biomaterials
Nazgul Tuleuova, Ji Youn Lee, Jennifer Lee, Erlan Ramanculov, Mark Α. Zern, Alexander Revzin,
The success in driving embryonic stem cells towards hepatic lineage has been confounded by the complexity and cost of differentiation protocols that employ large quantities of expensive growth factors (GFs). Instead of supplementing culture media with soluble GFs, we investigated cultivation and differentiation of mouse embryonic stem cells (mESCs) on printed arrays of GFs. Hepatocyte growth factor (HGF), basic fibroblast growth factor (bFGF) and bone morphogenetic protein (BMP4) were mixed in solution ...
Tópico(s): Liver physiology and pathology
2010 - Elsevier BV | Biomaterials
Nazgul Tuleuova, Caroline N. Jones, Jun Yan, Erlan Ramanculov, Yohei Yokobayashi, Alexander Revzin,
Traditional antibody-based affinity sensing strategies employ multiple reagents and washing steps and are unsuitable for real-time detection of analyte binding. Aptamers, on the other hand, may be designed to monitor binding events directly, in real-time, without the need for secondary labels. The goal of the present study was to design an aptamer beacon for fluorescence resonance energy transfer (FRET)-based detection of interferon-gamma (IFN-γ)—an important inflammatory cytokine. Variants of DNA ...
Tópico(s): Advanced Biosensing Techniques and Applications
2010 - American Chemical Society | Analytical Chemistry
Emil Omurzak, Janar Jasnakunov, Nazgul Mairykova, Alima Abdykerimova, Aigul Maatkasymova, Saadat Sulaimankulova, Mitsuhiro Matsuda, Minoru Nishida, Hirotaka Ihara, Tsutomu Mashimo,
A new synthesis method of nanomaterials using pulsed plasma in liquid by the low voltage spark discharge is presented. The fullerene C60 and TiO nanopowder were for the first time synthesized by electric discharge method in liquid. The purity of C60 was >99%, which is much higher than those by the conventional arc plasma in inert gas methods (less than 80% C60 and 20% C70 and other fullerenes). Copper nanoparticles prepared by this method were smaller than those by arc method by a factor of >5. The ...
Tópico(s): Carbon Nanotubes in Composites
2007 - American Scientific Publishers | Journal of Nanoscience and Nanotechnology
This paper establishes asymptotic normality and uniform consistency with convergence rates of the local linear estimator for spatial near-epoch dependent (NED) processes. The class of the NED spatial processes covers important spatial processes, including nonlinear autoregressive and infinite moving average random fields, which generally do not satisfy mixing conditions. Apart from accommodating a larger class of dependent processes, the proposed asymptotic theory allows for triangular arrays of ...
Tópico(s): Economic and Environmental Valuation
2011 - Elsevier BV | Journal of Econometrics
Mahboobe Ghaedi, Nazgul Tuleuova, Mark Α. Zern, Jian Wu, Alexander Revzin,
The capacity of stem cells to differentiate into specific cell types makes them very promising in tissue regeneration and repair. However, realizing this promise requires novel methods for guiding lineage-specific differentiation of stem cells. In this study, hepatocyte growth factor (HGF), an important morphogen in liver development, was co-printed with collagen I (Col) to create arrays of protein spots on glass. Human adipose stem cells (ASCs) were cultured on top of the HGF/Col spots for 2 weeks. ...
Tópico(s): 3D Printing in Biomedical Research
2011 - Elsevier BV | Biochemical and Biophysical Research Communications
Francisco Hita Garcia, Brian L. Fisher,
... Tetramorium marojejy sp. n., Tetramorium latreillei Forel, Tetramorium nazgul sp. n., Tetramorium sabatra sp. n., and Tetramorium ...
Tópico(s): Animal and Plant Science Education
2012 - Q15088586 | Zootaxa
Nazgul Jenish, Ingmar R. Prucha,
The development of a general inferential theory for nonlinear models with cross-sectionally or spatially dependent data has been hampered by a lack of appropriate limit theorems. To facilitate a general asymptotic inference theory relevant to economic applications, this paper first extends the notion of near-epoch dependent (NED) processes used in the time series literature to random fields. The class of processes that is NED on, say, an α-mixing process, is shown to be closed under infinite transformations, ...
Tópico(s): Regional Economics and Spatial Analysis
2012 - Elsevier BV | Journal of Econometrics
Qing Zhou, Ying Liu, Dong‐Sik Shin, Jaime Silangcruz, Nazgul Tuleuova, Alexander Revzin,
Aptamers have recently emerged as an excellent alternative to antibodies because of their inherent stability and ease of modification. In this paper, we describe the development of an aptamer-based surface for capture of cells expressing CD4 antigen. The glass or silicon surfaces were modified with amine-terminated silanes and then modified with thiolated RNA aptamer against CD4. Modification of the surface was first characterized by ellipsometry to demonstrate assembly of biointerface components ...
Tópico(s): Advanced Biosensing Techniques and Applications
2012 - American Chemical Society | Langmuir
This paper proposes a semiparametric generalized method of moments estimator (GMM) estimator for a partially parametric spatial model with endogenous spatially dependent regressors. The finite-dimensional estimator is shown to be consistent and root-n asymptotically normal under some reasonable conditions. A spatial heteroscedasticity and autocorrelation consistent covariance estimator is constructed for the GMM estimator. The leading application is nonlinear spatial autoregressions, which arise ...
Tópico(s): Fiscal Policy and Economic Growth
2014 - Cambridge University Press | Econometric Theory
Abdumauvlen Berdyshev, Erkinjon Karimov, N. S. Akhtaeva,
... Site Citation Abdumauvlen S. Berdyshev, Erkinjon T. Karimov, Nazgul S. Akhtaeva; On a boundary-value problem for ...
Tópico(s): Numerical methods in inverse problems
2014 - American Institute of Physics | AIP conference proceedings
Stephen J. Ahern, Mayukh Das, T. S. Bhowmick, Ry Young, C. F. Gonzalez,
... and Salvo belong. The lysis genes of the Nazgul-like phage type include a gene that encodes ...
Tópico(s): Bacteriophages and microbial interactions
2013 - American Society for Microbiology | Journal of Bacteriology
This paper reviews two main strategies for dealing with the threat posed by radically enactive/embodied cognition to traditional cognitive science. Both strategies invoke action oriented representations (AORs). They differ in emphasizing different features of AORs in their attempt to answer the REC threat – focusing on their contents and vehicles, respectively. The first two sections review the central motivations and rationales driving the ‘content’ and ‘format’ strategies in turn and raise initial ...
Tópico(s): Psychology of Moral and Emotional Judgment
2013 - SAGE Publishing | Adaptive Behavior
Yekaterina O. Ostapchuk, Esin Aktaş Çetin, Yuliya V. Perfilyeva, Abdullah Yılmaz, Yuriy Skiba, Alexandr Chirkin, Nazgul A. Omarbaeva, Shynar G. Talaeva, Nikolai N. Belyaev, Günnur Deniz,
Human natural killer (NK) cells are not only professional cytotoxic cells integrated into effector branch of innate immunity, but they are also regulatory cells, managing different immune processes. Immunoregulatory NK cells, expressing HLA-G and IL-10, have been generated in vitro from human hematopoietic progenitors and found in vivo among decidual NK cells of pregnant women. Human peripheral blood NK cells have been shown to acquire suppressive properties after HLA-G uptake during trogocytosis. ...
Tópico(s): Immune Cell Function and Interaction
2015 - Elsevier BV | Cellular Immunology
Nazgul Tazhigaliyeva, Yerassyl Diyas, Dmitriy Brakk, Yernar Aimambetov, Anara Sandygulova,
The goal of this ongoing research is to examine the feasibility of using a social humanoid robot to teach children the basics of programming. We focus on exploring robot's adaptive strategies in order to facilitate both effective educational applications and engaging child-robot interaction. In this paper we present our preliminary work, which explores robot's social roles (peer versus teacher) and their effect on learning. The child needs to learn the basics of programming in order to walk the robot ...
Tópico(s): Reinforcement Learning in Robotics
2016 - Springer Science+Business Media | Lecture notes in computer science
Minhui He, Vladimir V. Shishov, Nazgul Kaparova, Bao Yang, Achim Bräuning, Jussi Grießinger,
Response of climate warming on tree-ring formation has attracted much attention during recent years. However, most studies are based on statistical analysis, lacking understanding of tree-physiological processes, especially in the mountainous regions of the Tibetan Plateau (TP). Herein, we firstly use an updated new version of the tree-ring process-based Vaganov-Shashkin model (VS-oscilloscope) to simulate tree-ring formation and its relationships with climate factors during the past six decades. ...
Tópico(s): Ecology and Vegetation Dynamics Studies
2017 - Elsevier BV | Dendrochronologia
Stefanie Ryglewski, Carsten Duch, Benjamin Altenhein,
... of a candidate enzyme for TA catabolism, named nazgul (Naz), in flight motor behavioral control. We hypothesize ...
Tópico(s): Insect behavior and control techniques
2017 - Frontiers Media | Frontiers in Systems Neuroscience
Evan S. H. Quah, SHAHRULM.S. ANUAR, L. Lee Grismer, Perry L. Wood, Siti Azizah, Mohd Abdul Muin,
... gln), we determine that this new species, Abavorana nazgul sp. nov., is the sister lineage to other ...
Tópico(s): Bat Biology and Ecology Studies
2017 - Q15088586 | Zootaxa
Nazgul Dastanova, Sultan Duisenbay, Olga Krestinskaya, Alex Pappachen James,
In this paper, we present the hardware implementation of a novel algorithm for moving-object detection, which can be integrated with CMOS image sensors. Bit planes of consecutive frames are stored in memristive crossbar arrays and compared using threshold-logic XOR gates. The resulting outputs are combined using weighted summation circuits and thresholded using comparators, to obtain binary images. A resistive content-addressable memory (CAM) array is used in the output stage to observe the numbers ...
Tópico(s): Visual Attention and Saliency Detection
2018 - Institute of Electrical and Electronics Engineers | IEEE Access