National Bureau of Economic Research (NBER)
Thomas G. von Lueder, S. Jeson Sangaralingham, Bing H. Wang, Andrew R. Kompa, Dan Atar, John C. Burnett, Henry Krum,
... potentially has beneficial CV effects. Inhibition of NEP (NEPi) has been advanced as a therapeutic modality. If neprilysin only targeted NPs, NEPi would augment the vasodilating and natriuretic actions afforded ... to catabolize numerous substrates also means that sole NEPi yields broader effects than anticipated, and explains why NEPi is best combined with the inhibition of other ... short bioavailability. For the class of single-acting NEPi, as discussed below, their effectiveness to promote the ... NPs, or indirectly by preventing NP degradation (through NEPi). In particular, degradation-resistant NPs, including designer NPs, ...
Tópico(s): Cardiovascular Function and Risk Factors
2013 - Lippincott Williams & Wilkins | Circulation Heart Failure
Qian Pu, Pascal Brassard, Danesh Javeshghani, Marc Iglarz, Randy L. Webb, Farhad Amiri, Ernesto L. Schiffrin,
... enzyme inhibitor (ACEI) with a neutral endopeptidase inhibitor (NEPI) has potent blood pressure (BP) lowering action, but ... 1 (AT1) receptor blocker (ARB, valsartan) and a NEPI (CGS 25354) in comparison with a dual ACEI/NEPI (CGS 30440) in stroke-prone spontaneously hypertensive rats ( ... BP of SHRSP was lowered by combined valsartan/NEPI and ACEI/NEPI slightly more than valsartan, whereas NEPI was ineffective. Valsartan, valsartan/NEPI and ACEI/NEPI normalized resistance artery relaxation responses to acetylcholine, and ...
Tópico(s): Renin-Angiotensin System Studies
2008 - Lippincott Williams & Wilkins | Journal of Hypertension
Fernando L. Martín, Tracy L. Stevens, Alessandro Cataliotti, John A. Schirger, Daniel D. Borgeson, Margaret M. Redfield, Andreas Luchner, John C. Burnett,
... inhibiting. We hypothesized that chronic oral NEP inhibition (NEPI), initiated in early experimental congestive heart failure (CHF), ... of sodium retention. We also hypothesized that chronic NEPI during progressive CHF (PCHF) would improve the natriuretic ... severe CHF, we defined the actions of chronic NEPI (candoxatril, 10 mg/kg, orally, twice a day) ... ResultsFrom baseline through the moderate phase of CHF, NEPI maintained sodium excretion. In contrast, in moderate CHF, ... In severe CHF, sodium excretion was higher with NEPI compared to control. Chronic NEPI also resulted in ...
Tópico(s): Neuropeptides and Animal Physiology
2005 - Elsevier BV | Kidney International
L. S. Hermann, Gunnar Lindberg, Ulf Lindblad, Arne Melander,
... diabetes L. S. Hermann, L. S. Hermann The NEPI Foundation, Malmö and Stockholm, Sweden Department of Medicine, ... papers by this authorG. Lindberg, G. Lindberg The NEPI Foundation, Malmö and Stockholm, SwedenSearch for more papers by this authorU. Lindblad, U. Lindblad The NEPI Foundation, Malmö and Stockholm, SwedenSearch for more papers by this authorA. Melander, A. Melander The NEPI Foundation, Malmö and Stockholm, SwedenSearch for more papers ... author L. S. Hermann, L. S. Hermann The NEPI Foundation, Malmö and Stockholm, Sweden Department of Medicine, ...
Tópico(s): Pharmaceutical Practices and Patient Outcomes
2002 - Wiley | Diabetes Obesity and Metabolism
Xiao-Ping Yang, Yun-He Liu, Edward L. Peterson, Oscar A. Carretero,
... the ACEi ramiprilat, the NEP-24.11 inhibitor (NEPi) CGS24592, or both. To test whether the effect of NEPi could be suppressed by blocking kinins or ANP, ... controls, infarct size/risk area was 69 ± 4%; NEPi reduced this to 24 ± 4% (p < 0.001) and ramiprilat to 20 ± 3% (p < 0.001). NEPi did not potentiate the effect of ramiprilat (infarct ... risk area, 18 ± 4%). The protective effect of NEPi was blocked by icatibant; infarct size/risk area, 61 ± 4%, significantly larger than NEPi alone (p < 0.001) but no different from controls. The effect of NEPi was slightly diminished by the ANP antagonist HS- ...
Tópico(s): Coagulation, Bradykinin, Polyphosphates, and Angioedema
1997 - Lippincott Williams & Wilkins | Journal of Cardiovascular Pharmacology
Kiyotaka Kugiyama, Seigo Sugiyama, Toshiyuki Matsumura, Yasutaka Ohta, Hideki Doi, Hirofumi Yasue,
... of UK79300 (candoxatril), an orally active NEP inhibitor (NEPI), on the development of atherosclerotic changes in high- ... n=15), or 1.5% cholesterol diet containing NEPI (20 mg·kg −1 ·d −1 ) (Cholesterol+NEPI, n=15). At the end of the dietary period, NEPI treatment was found to suppress the surface area ... plaques (% surface area: Cholesterol, 59±6 versus Cholesterol+NEPI, 36±7, P <.01) and decreased contents of cholesterol and cholesterol esters in the aortas. NEPI also reduced plasma total cholesterol by 27% of ... in response to acetylcholine, was preserved in Cholesterol+NEPI rabbits compared with that in Cholesterol rabbits. NEP ...
Tópico(s): Cardiovascular, Neuropeptides, and Oxidative Stress Research
1996 - Lippincott Williams & Wilkins | Arteriosclerosis Thrombosis and Vascular Biology
I. Pham, Walter González, Abdelaziz Amrani, M C Fournié-Zaluski, M. Philippe, I Laboulandine, B P Roques, J B Michel,
... The effects of a highly selective NEP inhibitor (NEPI), retrothiorphan, of a converting enzyme inhibitor (CEI), enalaprilat, and of the combination, CEI + NEPI, were assessed in deoxycorticosterone acetate (DOCA)-salt hypertensive ... spontaneously hypertensive rats (SHRs) and renovascular hypertensive rats. NEPI increased diuresis, natriuresis and urinary cyclic GMP (cGMP), ANF and bradykinin in the three models. NEPI decreased blood pressure in DOCA-salt hypertensive rats ... bradykinin in any of the three models. CEI + NEPI increased diuresis and natriuresis in DOCA-salt hypertensive ...
Tópico(s): Hormonal Regulation and Hypertension
1993 - American Society for Pharmacology and Experimental Therapeutics | Journal of Pharmacology and Experimental Therapeutics
Valérie Borrel, P. Thomas, Chloé Catovic, Pierre‐Jean Racine, Yoan Konto-Ghiorghi, Luc Lefeuvre, Cécile Duclairoir Poc, Christos C. Zouboulis, Marc Feuilloley,
... of catecholamines, i.e. epinephrine (Epi) and norepinephrine (Nepi), on two representative strains of C. acnes whose ... acneic and RT6 non-acneic strains. Epi and Nepi (10-6 M) had no impact on the ... Epi increased RT4 and RT6 biofilm formation whereas Nepi was only active on the RT4 strain. Same ... is also sensitive to catecholamines since Epi and Nepi affect its surface polarity. Flow cytometry studies revealed that Epi and Nepi are unable to induce major changes of the ... to control or catecholamines treated bacteria, Epi and Nepi were without effect on the cytotoxicity and inflammatory ...
Tópico(s): Oral microbiology and periodontitis research
2019 - Frontiers Media | Frontiers in Medicine
Jianping Zhang, Raymond Niaura, Joshua R. Dyer, Biing‐Jiun Shen, John F. Todaro, Jeanne M. McCaffery, Avron Spiro, Kenneth D. Ward,
... hypothesized that hostility may interact with circulating norepinephrine (NEPI) levels, indexed by 24-hour urine concentrations, to ... Cook-Medley Hostility (Ho) and 24-hour urine NEPI were used to predict insulin resistance defined by ... that the two-way interaction between Ho and NEPI significantly predicted HOMA and PCIL, but not PCGL, ... explored and indicated that, at higher levels of NEPI, higher Ho was associated with higher HOMA (β = ... of HOMA at mean and lower levels of NEPI. Similar results were obtained for PCIL, but not ...
Tópico(s): Blood Pressure and Hypertension Studies
2006 - Lippincott Williams & Wilkins | Psychosomatic Medicine
Adria Colletti, Kenneth R. Olson,
... 10 −8 M and 10 −6 M norepinephrine (NEPI) or epinephrine (EPI) and effluent from the arterioarterial ( ... After 20 minutes of continuous 10 −6 M NEPI perfusion, metabolites accounted for 70% and 96% of ... Gills perfused with a bolus of 3 H‐NEPI extracted 47% of the radiolabel. Continuous perfusion with ... M tyramine 30 minutes after the 3 H‐NEPI pulse released 3 H‐labeled and ‐unlabeled NEPI and metabolites into the AA effluent. Cocaine released more unmetabolized 3 H‐NEPI than tyramine, whereas tyramine released more 3 H‐ ...
Tópico(s): Physiological and biochemical adaptations
1988 - Wiley | Journal of Experimental Zoology
... ngono ya nyuma inasabibisha watu wazima wavae ‘pampers’ (nepi). Lakini uvumi huu hauhusu gayism peke yake tu. Uvumi juu ya nepi hurejelea pia nyufa za mwili zinazosabibishwa na ukahaba, ... za "uasherati." Makala hii inatafiti maana tofauti ya nepi katika mazumgumzo ya kila siku kwa ajiji ya ... Ninaonyesha vile uvumi juu ya watu wazima wanaovaa nepi wanafunua mahatari katika “tabaka zinazofichwa” za maisha ya kila siku nchini. Nepi ndiyo vitu vinavyotusaidia kuelewa uhusiano kati ya uraia ... hayo, ninafuata maandishi ya Sara Ahmed kusema kwamba nepi kuwa “vitu queer:” yaani, vitu vinavyoonyesha kwamba mapambano ...
Tópico(s): Feminism, Gender, and Sexuality Studies
2020 - Wiley | Cultural Anthropology
Francesco Di Gennaro, Orlando Cerasuolo, Cecilia Colonna, Ulla Rajala, Simon Stoddart, Nicholas P. Whitehead,
NUOVE RICERCHE SULLA CITTÀ E IL TERRITORIO DI NEPI (VT) In questo articolo si rendono noti i ... dei lavori nella città e nel territorio di Nepi (VT). Vengono dati un resoconto ccmpleto dei reperti ... tra il palazzo vescovile e la cattedrale di Nepi, una serie di stratificazioni che va dal settimo ... preliminare delle recenti indagini sistematiche del territorio di Nepi. In conclusione viene presentato un modello per lo ... del territorio e della topografla della città di Nepi dall'età del bronzo fino al periodo tardo ...
Tópico(s): Medieval Architecture and Archaeology
2002 - Cambridge University Press | Papers of the British School at Rome
N. P. Nekvasil, Kenneth R. Olson,
Abstract Tritiated norepinephrine (Nepi) or Epinephrine (Epi) was perfused through isolated gills of rainbow trout ( Salmo gairdneri ) and the affinity of vascular tissues ... cells in the filamental sinus accumulate 3 H‐Nepi extensively. The afferent and efferent filamental arteries and filamental nutrient vessels did not bind 3 H‐Nepi. Pillar cell and venous endothelial accumulation is selective for Nepi; Epi is not accumulated by these cells, and Nepi uptake can be inhibited by imipramine. These results ...
Tópico(s): Neuroscience of respiration and sleep
1985 - Wiley | Journal of Experimental Zoology
Yuan Liu, Xiaobin Hong, Bin Zhang,
... In this paper, a non-elliptical probability imaging (NEPI) method based on nonlinear ultrasonic guided waves is ... index (NDI) are defined and applied in the NEPI. By comparison with a reference point, the problem ... be solved analytically is avoided skillfully. Finally, the NEPI method is used to present the damage. The experiment results show that the NEPI method can accurately display the damage location. The ... time Fourier transform, and S-transform. The proposed NEPI method based on nonlinear ultrasonic guided waves can ...
Tópico(s): Structural Health Monitoring Techniques
2022 - SAGE Publishing | Structural Health Monitoring
... Orientalizing and Archaic settlement and funerary sites at Nepi (ancient Nepet), one of the first Latin colonies ... colonial developments to the Roman patterns from the Nepi Survey Project and the trends from other Latin ... effects of Roman colonialism. The evidence shows that Nepi seemed to develop as an independent city state ... Roman settlement pattern. The extensive ‘rural colonization’ at Nepi, similarly to Sutri and Cosa, started only in ...
Tópico(s): Ancient and Medieval Archaeology Studies
2016 - Cambridge University Press | Papers of the British School at Rome
... settlement in central Italy, using the territory of Nepi as an example of settlement aggregation in southern ... to the Iron Age in the territory of Nepi found during the Nepi Survey Project. This new evidence is discussed together ... After the settlement aggregated in one centre at Nepi, there are signs of further expansion in the ...
Tópico(s): Archaeological Research and Protection
2013 - Cambridge University Press | Papers of the British School at Rome
Jian Xu, Oscar A. Carretero, Y LIU, F YANG, Edward G. Shesely, Nancy Oja-Tebbe, Xiao Yang,
... than ACE or NEP inhibitors alone (ACEi and NEPi) and (2) the effects of these inhibitors are ... vehicle, ACEi (ramipril, 2.5 mg/kg/d), NEPi (candoxatril, 20 mg/kg/d) or VPi (omapatrilat, ... measured histopathologically. Results We found that ACEi or NEPi improved cardiac function and remodeling and that these ... VPi. Furthermore, the beneficial cardiac effects of ACEi, NEPi, and VPi were significantly attenuated in B2−/− mice. ... with VPi provides better cardioprotection than ACEi or NEPi alone in mice with congestive heart failure induced ...
Tópico(s): Peptidase Inhibition and Analysis
2004 - Elsevier BV | Journal of Cardiac Failure
Jiang Xu, Oscar A. Carretero, Yun-He Liu, Fang Yang, Edward G. Shesely, Nancy Oja-Tebbe, Xiao-Ping Yang,
... than ACE or NEP inhibitors alone (ACEi and NEPi) and (2) the effects of these inhibitors are ... vehicle, ACEi (ramipril, 2.5 mg/kg/d), NEPi (candoxatril, 20 mg/kg/d) or VPi (omapatrilat, ... were measured histopathologically.We found that ACEi or NEPi improved cardiac function and remodeling and that these ... VPi. Furthermore, the beneficial cardiac effects of ACEi, NEPi, and VPi were significantly attenuated in B(2)-/- ... with VPi provides better cardioprotection than ACEi or NEPi alone in mice with congestive heart failure induced ...
Tópico(s): Heart Failure Treatment and Management
2004 - Elsevier BV | Journal of Cardiac Failure
Victor G. Sharov, Anastassia Todor, George Suzuki, Hideaki Morita, Elaine J. Tanhehco, Hani N. Sabbah,
... hypoxia (HX), angiotensin‐II (A‐II) and norepinephrine (NEPI) can mediate apoptosis by activating p38 MAPK, and ... were subjected to HX or A‐II or NEPI with and without a p38 MAPK inhibitor (SB ... L and decreased cyclin D 1 expression, and NEPI‐induced apoptosis was associated with decreased cyclin D ... D 1 expression. Conclusions: HX, A‐II and NEPI mediate apoptosis in failing cardiomyocytes via different effects ... that apoptosis induced by HX, A‐II and NEPI involves activation of p38 MAPK upstream from Fas‐ ...
Tópico(s): Autophagy in Disease and Therapy
2003 - Elsevier BV | European Journal of Heart Failure
... Skaraborg Institute, Skövde, Sweden The Network of Pharmacoepidemiology (NEPI), Sweden Department of Community Medicine, Medical Research Centre, ... authorArne Melander, Arne Melander The Network of Pharmacoepidemiology (NEPI), Sweden Department of Community Medicine, Medical Research Centre, ... Skaraborg Institute, Skövde, Sweden The Network of Pharmacoepidemiology (NEPI), Sweden Department of Community Medicine, Medical Research Centre, ... authorArne Melander, Arne Melander The Network of Pharmacoepidemiology (NEPI), Sweden Department of Community Medicine, Medical Research Centre, ...
Tópico(s): Pharmacology and Obesity Treatment
2000 - Wiley | Diabetes Obesity and Metabolism
Clara Vollmer Barbosa, Hannah Lang, Anette Melk, Bernhard M.W. Schmidt,
... acute renal failure, the role of neprilysin inhibition (NEPi) is unclear and some physicians are reluctant to ... disease (CKD) or progression to dialysis on combined NEPi and ACEi/ARBs compared with ACEi or ARBs. ... OR 1.02 (0.84–1.23)]. Conclusion NEPi + ACEi/ARBs are safe in terms of renal ... CKD are needed to evaluate the effect of NEPi on decreasing progression of CKD.
Tópico(s): Bipolar Disorder and Treatment
2022 - Oxford University Press | Nephrology Dialysis Transplantation
Vajir Malek, Nisha Sharma, Himanshu Sankrityayan, Anil Bhanudas Gaikwad,
... NPS and RAS simultaneously using a neprilysin inhibitor (NEPi) in combination with either angiotensin receptor blocker (ARB) ... monotherapies, in preventing DN.Renoprotective potential of thiorphan (NEPi)/telmisartan (ARB) and thiorphan/Dize (ACE2 activator) combination ... fibrosis, and apoptosis. Hence, we can conclude that NEPi/ARB and NEPi/ACE2 activator combination therapies might be new therapeutic ...
Tópico(s): Diabetes Treatment and Management
2019 - Elsevier BV | Life Sciences
Nelson Sewankambo, Peter Donkor,
... Initiative (MEPI) and the Nursing Education Partnership Initiative (NEPI) were large undertakings that introduced major creative changes ... but to scale up beyond the MEPI and NEPI institutions and continue with shared learning and the ... best way forward in the post-MEPI and NEPI period. The African Forum for Research and Education ...
Tópico(s): Health and Medical Research Impacts
2018 - Elsevier BV | Annals of Global Health
Milan Wolf, Brad Hubbard, Atsushi Sakaoka, Serge Rousselle, Armando Téllez, Xiongjing Jiang, Kazuomi Kario, Mathias Hohl, Michael Böhm, Felix Mahfoud,
... IberisBloom (IBB)]. After 7 days, measurement of norepinephrine (NEPI) tissue concentrations and histological analyses have been performed.Renal NEPI tissue concentration following RDN was significantly reduced when ... millimeter length of renal artery and reduction in NEPI tissue concentration.The two devices under investigation demonstrated ... histopathological lesion characteristics and similar reduction of renal NEPI levels. An increase in number of ablations per ...
Tópico(s): Heart Rate Variability and Autonomic Control
2018 - Lippincott Williams & Wilkins | Journal of Hypertension
Katherine M. McKendy, Lawrence F. Lee, Kerianne Boulva, Dan Deckelbaum, David S. Mulder, Tarek Razek, Jeremy Grushka,
... with those were not treated with epidural analgesia (NEPI) using coarsened exact matching. Primary outcomes were respiratory ... support. Results About 1360 patients (EPI: 329 and NEPI: 1031) met inclusion criteria (mean age: 54.2 ... matching, 204 EPI patients were compared with 204 NEPI patients, with no differences in baseline characteristics. EPI ... mechanical ventilation (EPI: 148 h [SD: 167] versus NEPI: 117 h [SD: 187], P = 0.434), or ...
Tópico(s): Traumatic Ocular and Foreign Body Injuries
2017 - Elsevier BV | Journal of Surgical Research
Thomas G. von Lueder, Dan Atar, Henry Krum,
... actions in CVD. However, stand-alone NEP inhibitors (NEPi) lacked efficacy beyond standard pharmacotherapy. Combined blockers of ... A decade ago, omapatrilat and other dual-acting NEPi-ACEi (vasopeptidase-inhibitors) were promising agents for hypertension ... exploit clinical efficacy of combined RAAS-blockade and NEPi-mediated natriuretic peptide augmentation, and hopefully do so ... clinical safety. We herein review current knowledge of NEPi as stand-alone and combined pharmacotherapeutic agents in ...
Tópico(s): Renin-Angiotensin System Studies
2014 - Elsevier BV | Pharmacology & Therapeutics
Lyn Middleton, Andrea A. Howard, Jennifer Dohrn, Deborah von Zinkernagel, Deborah Parham Hopson, Barbara Aranda-Naranjo, Carolyn Hall, Address Malata, Thokozani Bvumbwe, Adeline Chabela, Nthabiseng Ann Molise, Wafaa El‐Sadr,
... population health needs. The Nursing Education Partnership Initiative (NEPI) was established in 2011 by the U.S. ... nursing and midwifery education in Sub-Saharan Africa. NEPI has formed partnerships with governments and key stakeholders ... and midwifery education institutions and 1 nursing council. NEPI has been informed by activities that strengthen education ...
Tópico(s): Global Health and Surgery
2014 - Lippincott Williams & Wilkins | Academic Medicine
Jian Hao, Ruijin Liao, Zhipeng Ma, Lijun Yang,
... main insulation system using natural ester-pressboard insulation (NEPI) system and mineral oil-pressboard insulation (MOPI) system, ... with the MOPI with low moisture content, the NEPI with the same low moisture content has higher ... show that the dielectric loss difference between the NEPI system and the MOPI system with low moisture ... the 'fingerprint' of the ageing condition of the NEPI system and the mineral-oil pressboard insulation system.
Tópico(s): Power Systems Fault Detection
2012 - Institution of Engineering and Technology | IET Science Measurement & Technology
Michael J. Iatropoulos, Gary M. Williams,
... the dissipation of oxidation energy as heat. Norepinephrine (NEPI) binds to the β3-adrenoreceptor in BA leading ... LPL), which stimulates lipolysis and liberates FFA. Both NEPI and insulin (I) stimulate glucose uptake by BA, and NEPI increases UCP in BA. Nitric oxide (NO) stimulates ... transcription factor A (mtTFA). Thus, UCP, T3, I, NEPI, NO, PPARCA1, cGMP, eNOS, NRF-1 and mtTFA ...
Tópico(s): Muscle metabolism and nutrition
2004 - Japanese Society of Toxicologic Pathology | Journal of Toxicologic Pathology