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Dennis Cartwright, Matt Dickinson Chief Sports Correspondent, Janice Turner, Amanda Andrews, Christina Hardyment, David Wighton, Alexi Mostrous, John McNamara, Robert Cole, Richard Ellis, Matthew Syed, Tom Jenkins, Patrick Foster Media Correspondent, Alexandra Frean, Tim Albone, Caroline Stacey, David Aaronovitch, Gary Duncan, Simon Barnes, Fiona Maddocks, Robin Pagnamenta Energy and Environment Editor, Amanda Ursell, Peter Lansley, Jane MacQuitty, Simon Hills, Robert Lindsay, Claire McDonald, Mark Souster, Philip Clothier, John Mulvey, Jeremy A. Woodcock, Jane Knight, Bill Jarvis, Professor Bob Garratt, Ivo Tennant, Mr Azhar Aslam, Dr Rita Rakus MBBS, Emma Cook, Clare Lazaro, Tony Turnbull, Philip Howard, Sarah Urwin Jones, Carol Midgley, Jonny Wilkinson, David Chater, Ben Hoyle Arts Reporter, Rachel Campbell-Johnston, James Bone, Andy Hayman, Dominic Wells, Clive Davis, Mike Mulvlhill, Jake Elliott, Lynne Truss, Lucia Van Der Post, Carl Mortished, Jayne Wilson, Lauren Thompson, Khaled Hosseini, Sam Marlowe, Wendy Ide, James Hider, John Bungey, Mr Lucian Ion, Lucy Bannerman, Joanna Sugden, Nilgin Yusuf, Katle Duval, Giles Coren, W. M. R. Pumfrey, Robin Pagnamenta, Vivienne Parry, Martin Fletcher, Sean O'Neill Crime Editor, Pat Gibson, Ronni Ancona, Jane MacArtney, Rob Crilly, Hannah Fletcher, Rachel Sylvester, Francis Elliott, Jack Malvern, Ruth Gledhill, Debra Craine, Ruth Corbett, James Turner, Tom Charity, Allan Simmons, Peter Stiff, Norman Harris, Tim Reid, Rosemary Bennett, Daniel Finkelstein, Michael Reynolds, Ruth Gledhill Religion Correspondent, Dalya Alberge Arts Correspondent, Dan Sabbagh, Sergey Dolzhenko, Jeanette Winterson, Bishop Trevor Mwamba, Peter Ackroyd, Richard Ford Home Correspondent, Jo Morris, Doug Johnstone, Laura Dixon, W. H. Lewis, C. S. Lewis, Nico Hines, Anatole Kaletsky, Michael Caplan, QC, Sophie Harris, Rhys Blakely, Valerie Elliott Consumer Editor, Andrew Ellson Personal Finance Editor, David Hands, Charles Bremner, Geoffrey Boycott, Caroline White, Ron Lewis, Martin Symington, Ben MacHell, Lisa Armstrong Fashion Editor, Lucy Sweeney, Tim Teeman, Sara Thornton, Susan Thompson, Derwent May, Hugo Rifkind, Ms Angelica Kavouni MD FRCS EBOPRAS Cosmetic Plastic Surgeon, William Drew, Kate Muir, David Miliband, Malcolm Farrow, Richard Hobson Deputy Cricket Correspondent, Tom Whitwell, Ed Potton, Suzy Jagger, Gary Duncan Economics Editor, Oliver Kay, Trevor Johnston, Stephen Anderton, Roger J. Casson, Sarah Vine, Mark Atherton, Lisa Armstrong, John Westerby, Patrick Hosking Banking and Finance Editor, Neil Harman, Vikram Seth, Jane Wheatley, Jenny Lewis, Terry Lockhart, Sally Baker, Douglas Rankine, Pete Paphides, Simon de Bruxelles, John Hopkins Golf Correspondent, Rob Wright, Andrew Motion, J. W. Lewis, Christina Koning, Neil Harman Tennis Correspondent, Professor Emeritus Bob Spence, Anne Barrowclough, Tony Evans, Craig Tregurtha, Raymond Keene, Adam Sage, Suzi Godson, Richard Siklos, Lewis Smith, Hilary Freeman, Kate Saunders, Matt Hughes, Gordon Ramsay, Salley Vickers, Tom McIntyre, Dr Keith Hopcroft, Emma Inkester, Rick Jones, Neville Scott, Chris Campling, Alice Thomson, Fran Yeoman, Patrick Hosking, Richard Owen, Sarah Maslin Nir, Marcus Leroux, Rebecca O'connor, Ross Leckie, Erica Wagner, Marcel Berlins, James Charles, Peter Dixon, Nick Hasell, Thomasina Miers, Christian Pambrun, Carolyn Asome, David Hands Rugby Correspondent, Tom Dart, Owen Slot Chief Sports Reporter, James Collard, Paul Simons, Kevin Maher, Michael Herman, Nicholas Clee, Mike Mulvihill, Nigel Kendall, Gerard Baker US Editor, Joanna Pitman, Matthew Chalmers, Jonathan Clayton, Richard Ehrlich, Robert Crampton, Dom Phillips, Liz Hollis, Harriet Addison, Dominic Maxwell, Prue White, Matthew Parris, Amanda Cartlidge, John Polkinghorne, Amanda Craig, George Caulkin, Tim Wapshott, Russell Jenkins, Caitlin Moran, Michael Austin, Alan Lee, Neil Fisher, Iain Finlayson, Ian Arnott, Hank Paulson, Simon Annand, Joe Clay, David Hutcheon, Philip Webster, John Naish, Meg Wolitzer, Mark Henderson, Robert Baty, Chris Ayres, Lewis Smith Environment Reporter, Valentine Low, Martin Waller, Bradley Scheffer, Douglas Deeks, Mark Baldwin, Ian Hunter, Ashling O'Connor, Benedict Nightingale, Anna Shepard, Rob Green, Louise Cohen, Dr Thomas Stuttaford, Stephen Dalton, Nicola Woolcock, The Rev Michael Bentley, Alyson Rudd, Richard Morrison, Tony Halpin, James Christopher, David Budworth, Simon Crompton, Alan Lee Racing Correspondent, Alan Jackson, Matt Roberts, Steve Hawkes Retail Correspondent, Rev Louis a Ewart, Kim Newman, Alex Hardy, Fiona Hamilton, Garry Jenkins, Antonia Southern, Richard Ford, Christopher Irvine,

... Na, 18,125min Stars: Kim Yun Seok, Ha Jung Woo, Seo Yeong Hie On selected release Films ...

2008 - Gale Group | TDA

Capítulo de livro Acesso aberto Revisado por pares

Konstantin Schall, Kai Uwe Barthel, Nico Hezel, Klaus Jung,

Even though it has extensively been shown that retrieval specific training of deep neural networks is beneficial for nearest neighbor image search quality, most of these models are trained and tested in the domain of landmarks images. However, some applications use images from various other domains and therefore need a network with good generalization properties - a general-purpose CBIR model. To the best of our knowledge, no testing protocol has so far been introduced to benchmark models with respect ...

Tópico(s): Domain Adaptation and Few-Shot Learning

2022 - Springer Science+Business Media | Lecture notes in computer science

Artigo Acesso aberto Revisado por pares

Raphael Romano Bruno, Nico Bruining, Christian Jung, Malte Kelm, Georg Wolff, Bernhard Wernly,

A tool for the intensive care unit emerging from the entertainment industryVirtual and augmented reality (VR/AR) are becoming increasingly familiar to us from science fiction and are now commonly used for entertainment.In VR, the user wears special glasses to immerse them entirely into an artificial three-dimensional world (VR) or to integrate different imaging modalities superimposing virtual elements into a real-world environment (AR).For VR, various applications are helpful in intensive care medicine ...

Tópico(s): Family and Patient Care in Intensive Care Units

2022 - Springer Science+Business Media | Intensive Care Medicine

Artigo Acesso aberto Revisado por pares

Christoph Bobeth, Marzia Bordone, Nico Gubernari, Martin Jung, Danny van Dyk,

Abstract We analyze in detail the angular distributions in $${\bar{B}}\rightarrow D^*\ell {{\bar{\nu }}}$$ B ¯ → D ∗ ℓ ν ¯ decays, with a focus on lepton-flavour non-universality. We investigate the minimal number of angular observables that fully describes current and upcoming datasets, and explore their sensitivity to physics beyond the Standard Model (BSM) in the most general weak effective theory. We apply our findings to the current datasets, extract the non-redundant set of angular observables from the data, and ...

Tópico(s): High-Energy Particle Collisions Research

2021 - Springer Science+Business Media | The European Physical Journal C

Artigo Acesso aberto Revisado por pares

Anne‐Dorothee Steinkamp, Nico Seling, Soo-Jung Lee, Ebbe Boedtkjer, Carsten Bolm,

Two analogs of S0859 have been synthesized and their effects on Na + ,HCO 3 − co-transport activity have been evaluated.

Tópico(s): Phenothiazines and Benzothiazines Synthesis and Activities

2015 - Royal Society of Chemistry | MedChemComm

Artigo Acesso aberto Revisado por pares

Maximilian Linxweiler, Stefan Schorr, Nico Schäuble, Martin Jung, Johannes Linxweiler, Frank Langer, Hans‐Joachim Schäfers, Adolfo Cavalié, Richard Zimmermann, Markus Greiner,

Abstract Background Tumor cells benefit from their ability to avoid apoptosis and invade other tissues. The endoplasmic reticulum (ER) membrane protein Sec62 is a key player in these processes. Sec62 is essential for cell migration and protects tumor cells against thapsigargin-induced ER stress, which are both linked to cytosolic Ca 2+ . SEC62 silencing leads to elevated cytosolic Ca 2+ and increased ER Ca 2+ leakage after thapsigargin treatment. Sec62 protein levels are significantly increased in ...

Tópico(s): Microtubule and mitosis dynamics

2013 - BioMed Central | BMC Cancer

Capítulo de livro Revisado por pares

Konstantin Schall, Nico Hezel, Klaus Jung, Kai Uwe Barthel,

Vibro represents a powerful tool for interactive video retrieval and browsing and is the winner of the Video Browser Showdown 2022. Following the saying of "never change a winning system" we did not change any of the underlying concepts nor added any new features. Instead, we focused on improving the three existing cornerstones of the software, which are text-to-image search, image-to-image search and browsing results with 2D sorted maps. The changes to these three parts are summarized in this paper, ...

Tópico(s): Video Analysis and Summarization

2023 - Springer Science+Business Media | Lecture notes in computer science

Artigo Acesso aberto Revisado por pares

Craig W. Herbold, Laura E. Lehtovirta‐Morley, Man‐Young Jung, Nico Jehmlich, Bela Hausmann, Ping Han, Alexander Loy, Michael Pester, Luis A. Sayavedra‐Soto, Sung‐Keun Rhee, James I. Prosser, Graeme W. Nicol, Michael Wagner, Cécile Gubry‐Rangin,

Obligate acidophilic members of the thaumarchaeotal genus Candidatus Nitrosotalea play an important role in nitrification in acidic soils, but their evolutionary and physiological adaptations to acidic environments are still poorly understood, with only a single member of this genus (Ca. N. devanaterra) having its genome sequenced. In this study, we sequenced the genomes of two additional cultured Ca. Nitrosotalea strains, extracted an almost complete Ca. Nitrosotalea metagenome-assembled genome ...

Tópico(s): Wastewater Treatment and Nitrogen Removal

2017 - Wiley | Environmental Microbiology

Artigo Acesso aberto Revisado por pares

Stefan Schorr, Marie-Christine Klein, Igor Gamayun, Armin Melnyk, Martin Jung, Nico Schäuble, Qian Wang, Birgit Hemmis, Florian Bochen, Markus Greiner, Pavel Lampel, Sabine Urban, Sarah Haßdenteufel, Johanna Dudek, Xing‐Zhen Chen, Richard Wagner, Adolfo Cavalié, Richard Zimmermann,

In mammalian cells, signal peptide-dependent protein transport into the endoplasmic reticulum (ER) is mediated by a dynamic polypeptide-conducting channel, the heterotrimeric Sec61 complex. Previous work has characterized the Sec61 complex as a potential ER Ca2+ leak channel in HeLa cells and identified ER lumenal molecular chaperone immunoglobulin heavy-chain-binding protein (BiP) as limiting Ca2+ leakage via the open Sec61 channel by facilitating channel closing. This BiP activity involves binding ...

Tópico(s): RNA Interference and Gene Delivery

2015 - Elsevier BV | Journal of Biological Chemistry

Artigo Acesso aberto Revisado por pares

Jen-Feng Lai, Carlene L. Zindl, Lynn B. Duffy, T. Prescott Atkinson, Yong Woo Jung, Nico van Rooijen, Ken B. Waites, Duncan C. Krause, David Chaplin,

Mycoplasma pneumoniae (Mp), a common cause of pneumonia, is associated with asthma; however, the mechanisms underlying this association remain unclear. We investigated the cellular immune response to Mp in mice. Intranasal inoculation with Mp elicited infiltration of the lungs with neutrophils, monocytes and macrophages. Systemic depletion of macrophages, but not neutrophils, resulted in impaired clearance of Mp from the lungs. Accumulation and activation of macrophages were decreased in the lungs ...

Tópico(s): Immune Response and Inflammation

2010 - Public Library of Science | PLoS ONE

Artigo Acesso aberto Revisado por pares

Inge Huitinga, Sigrid R. Ruuls, Steffen Jung, Nico van Rooijen, H.‐P. Hartung, C.D. Dijkstra,

SUMMARY About 50% of the mononuclear cells in the perivascular lesions in the central nervous system (CNS) of rats suffering from experimental allergic encephalomyelitis (EAE) are blood-borne macrophages. In this study we investigated the role of these macrophages in different variants of EAE, using a liposome-mediated macrophage depletion technique. Intravenously injected liposomes containing dichloromethylene diphosphonate (C12MDP) are ingested by macrophages and cause temporary and selective elimination ...

Tópico(s): Immune Response and Inflammation

1995 - Oxford University Press | Clinical & Experimental Immunology

Artigo Acesso aberto Revisado por pares

Jung‐Min Ahn, Frederik M. Zimmermann, Nils P. Johnson, Eun‐Seok Shin, Bon‐Kwon Koo, Pil Hyung Lee, Duk‐Woo Park, Soo‐Jin Kang, Seung–Whan Lee, Young‐Hak Kim, Cheol Whan Lee, Seong‐Wook Park, Nico H.J. Pijls, Seung‐Jung Park,

Fractional flow reserve (FFR) has proven to its prognostic and therapeutic value. However, the additive prognostic value of coronary flow reserve (CFR) remains unclear. This study sought to investigate the clinical utility of combined FFR and CFR measurements to predict outcomes.Using the prospective, multicentre Interventional Cardiology Research Incooperation Society-FFR registry, a total of 2088 lesions from 1837 patients were included in this substudy. Based on baseline and hyperaemic pressure ...

Tópico(s): Acute Myocardial Infarction Research

2017 - Oxford University Press | European Heart Journal

Artigo Acesso aberto Revisado por pares

Frank Erdmann, Nico Schäuble, Sven Lang, Martin Jung, Alf Honigmann, Mazen Ahmad, Johanna Dudek, Julia Benedix, Anke Harsman, Annika Kopp, Volkhard Helms, Adolfo Cavalié, Richard Wagner, Richard Zimmermann,

... for more papers by this author Nico Schäuble Nico Schäuble Medical Biochemistry and Molecular Biology, Saarland University, Homburg, Germany Search for more papers by this author Sven Lang Sven Lang Medical Biochemistry and Molecular Biology, Saarland University, Homburg, Germany Search for more papers by this author Martin Jung Martin Jung Medical Biochemistry and Molecular Biology, Saarland ... for more papers by this author Nico Schäuble Nico Schäuble Medical Biochemistry and Molecular Biology, Saarland University, Homburg, Germany Search for more papers by this author Sven Lang Sven Lang Medical Biochemistry and Molecular Biology, Saarland University, Homburg, Germany Search for more papers by this author Martin Jung Martin Jung Medical Biochemistry and Molecular Biology, Saarland ...

Tópico(s): Transgenic Plants and Applications

2010 - Springer Nature | The EMBO Journal

Artigo Acesso aberto Revisado por pares

Nico F. Leenstra, Oliver C. Jung, Addie Johnson, Klaus W. Wendt, Jaap E. Tulleken,

Good leadership is essential for optimal trauma team performance, and targeted training of leadership skills is necessary to achieve such leadership proficiency. To address the need for a taxonomy of leadership skills that specifies the skill components to be learned and the behaviors by which they can be assessed across the five phases of trauma care, the authors developed the Taxonomy of Trauma Leadership Skills (TTLS).Critical incident interviews were conducted with trauma team leaders and members ...

Tópico(s): Innovations in Medical Education

2015 - Lippincott Williams & Wilkins | Academic Medicine

Capítulo de livro Revisado por pares

Nico Hezel, Konstantin Schall, Klaus Jung, Kai Uwe Barthel,

In this paper, we present the newest version of our interactive video browser tool Vibro. For this iteration, we focused on improving the user interface to enable a more accessible temporal search, upgrading the shot-detection algorithm, replacing a keyword-based search with rich text input, and reducing query times by applying a graph-based approximate nearest neighbor search method. With these extensive updates, we feel well-equipped to handle the huge amounts of data coming our way in the next ...

Tópico(s): Multimodal Machine Learning Applications

2022 - Springer Science+Business Media | Lecture notes in computer science

Artigo Acesso aberto Revisado por pares

Danny van Dyk, Frederik Beaujean, T. Blake, Christoph Bobeth, Marzia Bordone, K. Dugic, Eike Eberhard, Nico Gubernari, E. Graverini, Martin Jung, Ahmet Kokulu, Stephan Kürten, Domagoj Leljak, P. Lüghausen, Stefan Meiser, Mansour Rahimi, M. Reboud, R. Silva Coutinho, Javier Virto, K. Vos,

EOS is an open-source software for a variety of computational tasks in flavor physics. Its use cases include theory predictions within and beyond the Standard Model of particle physics, Bayesian inference of theory parameters from experimental and theoretical likelihoods, and simulation of pseudo events for a number of signal processes. EOS ensures high-performance computations through a C++ back-end and ease of usability through a Python front-end. To achieve this flexibility, EOS enables the user ...

Tópico(s): High-Energy Particle Collisions Research

2022 - Springer Science+Business Media | The European Physical Journal C

Artigo Acesso aberto Revisado por pares

Nico Schäuble, Sven Lang, Martin Jung, Sabine Cappel, Stefan Schorr, Özlem Ulucan, Johannes Linxweiler, Johanna Dudek, Robert Blum, Volkhard Helms, Adrienne W. Paton, James C. Paton, Adolfo Cavalié, Richard Zimmermann,

In mammalian cells, signal peptide-dependent protein transport into the endoplasmic reticulum (ER) is mediated by a dynamic protein-conducting channel, the Sec61 complex. Previous work has characterized the Sec61 channel as a potential ER Ca(2+) leak channel and identified calmodulin as limiting Ca(2+) leakage in a Ca(2+)-dependent manner by binding to an IQ motif in the cytosolic aminoterminus of Sec61α. Here, we manipulated the concentration of the ER lumenal chaperone BiP in cells in different ...

Tópico(s): Cellular transport and secretion

2012 - Springer Nature | The EMBO Journal

Artigo Acesso aberto Revisado por pares

Marzia Bordone, Nico Gubernari, Danny van Dyk, Martin Jung,

We carry out a comprehensive analysis of the full set of $\bar{B}_q \to D_q^{(*)}$ form factors for spectator quarks $q=u,d,s$ within the framework of the Heavy-Quark Expansion (HQE) to order $\mathcal{O}(\alpha_s, 1/m_b, 1/m_c^2)$. In addition to the available lattice QCD calculations we make use of two new sets of theoretical constraints: we produce for the first time numerical predictions for the full set of $\bar{B}_s \to D_s^{(*)}$ form factors using Light-Cone Sum Rules with $B_s$-meson distribution ...

Tópico(s): Black Holes and Theoretical Physics

2020 - Springer Science+Business Media | The European Physical Journal C

Artigo Acesso aberto Revisado por pares

Yong Zou, Sandra Wenzel, Nico Müller, Katja Prager, Elke‐Martina Jung, Erika Kothe, Tilman Kottke, Maria Mittag,

Cryptochromes are known as flavin-binding blue light receptors in bacteria, fungi, plants, and insects. The animal-like cryptochrome (aCRY) of the green alga Chlamydomonas reinhardtii has extended our view on cryptochromes, because it responds also to other wavelengths of the visible spectrum, including red light. Here, we have investigated if aCRY is involved in the regulation of the sexual life cycle of C. reinhardtii, which is controlled by blue and red light at the steps of gametogenesis along ...

Tópico(s): Algal biology and biofuel production

2017 - Oxford University Press | PLANT PHYSIOLOGY

Artigo Acesso aberto Revisado por pares

Nico Blüthgen, Nadja K. Simons, Kirsten Jung, Daniel Prati, Swen C. Renner, Steffen Boch, Markus Fischer, Norbert Hölzel, Valentin H. Klaus, Till Kleinebecker, Marco Tschapka, Wolfgang W. Weisser, Martin M. Goßner,

Abstract Human land use may detrimentally affect biodiversity, yet long-term stability of species communities is vital for maintaining ecosystem functioning. Community stability can be achieved by higher species diversity (portfolio effect), higher asynchrony across species (insurance hypothesis) and higher abundance of populations. However, the relative importance of these stabilizing pathways and whether they interact with land use in real-world ecosystems is unknown. We monitored inter-annual fluctuations ...

Tópico(s): Plant and animal studies

2016 - Nature Portfolio | Nature Communications

Artigo Acesso aberto Revisado por pares

Idan Milo, Anita Sapoznikov, Vyacheslav Kalchenko, Orna Tal, Rita Krauthgamer, Nico van Rooijen, Diana Dudziak, Steffen Jung, Guy Shakhar,

Key Points Soluble blood-borne antigens are crosspresented in the BM, triggering T-cell arrest, clustering, and in situ proliferation. In the BM, not only DCs but also other mononuclear phagocytes participate in crosspresentation.

Tópico(s): Immune Response and Inflammation

2013 - Elsevier BV | Blood

Artigo Revisado por pares

Seung‐Jung Park, Jung‐Min Ahn, Nico H.J. Pijls, Bernard De Bruyne, Eun Bo Shim, Young Tae Kim, Soo‐Jin Kang, Hae‐Geun Song, Jong‐Young Lee, Won‐Jang Kim, Duk‐Woo Park, Seung–Whan Lee, Young‐Hak Kim, Cheol Whan Lee, Seong‐Wook Park,

Functional lesion assessment for coronary tandem lesions and its clinical applications have not been thoroughly studied. The aim of this study was to test the hypothesis that the fractional flow reserve (FFR) gradient across an individual stenosis (ΔFFR) during pressure-wire pullback is a surrogate of the relative functional severity of each stenosis in coronary tandem lesions. For in vitro validation, computational flow dynamic modeling of coronary tandem lesion with various degree of stenosis was ...

Tópico(s): Cardiac Valve Diseases and Treatments

2012 - Elsevier BV | The American Journal of Cardiology

Artigo Acesso aberto Revisado por pares

Nico Schäuble, Adolfo Cavalié, Richard Zimmermann, Martin Jung,

According to live-cell calcium-imaging experiments, the Sec61 complex is a passive calcium-leak channel in the human endoplasmic reticulum (ER) membrane that is regulated by ER luminal immunoglobulin heavy chain binding protein (BiP) and cytosolic Ca(2+)-calmodulin. In single channel measurements, the open Sec61 complex is Ca(2+) permeable. It can be closed not only by interaction with BiP or Ca(2+)-calmodulin, but also with Pseudomonas aeruginosa Exotoxin A which can enter human cells by retrograde ...

Tópico(s): Clostridium difficile and Clostridium perfringens research

2013 - Taylor & Francis | Channels

Artigo Revisado por pares

Maik Lange, S. Braune, Karola Lüetzow, K. Richau, Nico Scharnagl, Marie Weinhart, Axel T. Neffe, F. Jung, Rainer Haag, Andreas Lendlein,

Abstract Materials for biomedical applications are often chosen for their bulk properties. Other requirements such as a hemocompatible surface shall be fulfilled by suitable chemical functionalization. Here we show, that linear, side‐chain methylated oligoglycerols (OGMe) are more stable to oxidation than oligo(ethylene glycol) (OEG). Poly(ether imide) (PEI) membranes functionalized with OGMes perform at least as good as, and partially better than, OEG functionalized PEI membranes in view of protein ...

Tópico(s): Fuel Cells and Related Materials

2012 - Wiley | Macromolecular Rapid Communications

Artigo Acesso aberto Revisado por pares

Viktor Klippenstein, Madhusmita Tripathy, Gerhard Jung, Friederike Schmid, Nico F. A. van der Vegt,

Preserving the correct dynamics at the coarse-grained (CG) level is a pressing problem in the development of systematic CG models in soft matter simulation. Starting from the seminal idea of simple time-scale mapping, there have been many efforts over the years toward establishing a meticulous connection between the CG and fine-grained (FG) dynamics based on fundamental statistical mechanics approaches. One of the most successful attempts in this context has been the development of CG models based ...

Tópico(s): Theoretical and Computational Physics

2021 - American Chemical Society | The Journal of Physical Chemistry B

Artigo Revisado por pares

Andreas Bertsch, Stephan Jung, Alexandra Zerck, Nico Pfeifer, Sven Nahnsen, Carsten Henneges, Alfred Nordheim, Oliver Kohlbacher,

Targeted proteomic approaches such as multiple reaction monitoring (MRM) overcome problems associated with classical shotgun mass spectrometry experiments. Developing MRM quantitation assays can be time consuming, because relevant peptide representatives of the proteins must be found and their retention time and the product ions must be determined. Given the transitions, hundreds to thousands of them can be scheduled into one experiment run. However, it is difficult to select which of the transitions ...

Tópico(s): Analytical Chemistry and Chromatography

2010 - American Chemical Society | Journal of Proteome Research

Artigo Revisado por pares

Sara D. Leonhardt, Linda-Maria Jung, Thomas Schmitt, Nico Blüthgen,

Tópico(s): Insect and Pesticide Research

2010 - Springer Science+Business Media | Behavioral Ecology and Sociobiology

Artigo Revisado por pares

Nico Sollmann, Florian Trepte-Freisleder, Lucia Albers, Nikolai H. Jung, Volker Mall, Bernhard Meyer, Florian Heinen, Sandro M. Krieg, Mirjam N. Landgraf,

Repetitive peripheral magnetic stimulation (rPMS) has been applied to musculoskeletal pain conditions. Since recent data show that migraine and tension-type headache (TTH) might be closely related to peripheral muscular pain in the neck and shoulder region (supporting the concept of the trigemino-cervical complex (TCC)), this pilot study explores the acceptance of rPMS to the upper trapezius muscles in migraine (partly in combination with TTH).We used rPMS to stimulate active myofascial trigger points ( ...

Tópico(s): Psychosomatic Disorders and Their Treatments

2016 - Elsevier BV | European Journal of Paediatric Neurology

Artigo Acesso aberto Revisado por pares

Jung‐Min Ahn, Frederik M. Zimmermann, Satish Arora, Ole Geir Solberg, Oskar Angerås, Katrine Rolid, Muzammil Rafique, Lars Aaberge, Kristjan Karason, Kozo Okada, Helen Luikart, Kiran K. Khush, Yasuhiro Honda, Nico H.J. Pijls, Sang Eun Lee, Jae‐Joong Kim, Seung‐Jung Park, Lars Gullestad, William F. Fearon,

Abstract Aims We evaluated the long-term prognostic value of invasively assessing coronary physiology after heart transplantation in a large multicentre registry. Methods and results Comprehensive intracoronary physiology assessment measuring fractional flow reserve (FFR), the index of microcirculatory resistance (IMR), and coronary flow reserve (CFR) was performed in 254 patients at baseline (a median of 7.2 weeks) and in 240 patients at 1 year after transplantation (199 patients had both baseline and ...

Tópico(s): Cardiac Structural Anomalies and Repair

2021 - Oxford University Press | European Heart Journal

Artigo Revisado por pares

Frederik M. Zimmermann, Bernard De Bruyne, Nico H.J. Pijls, Manisha Desai, Keith G. Oldroyd, Seung‐Jung Park, Michael J. Reardon, Olaf Wendler, Joseph Woo, Alan C. Yeung, William F. Fearon,

Guidelines recommend coronary artery bypass graft (CABG) surgery over percutaneous coronary intervention (PCI) for the treatment of 3-vessel coronary artery disease (3-VD). The inferior results of PCI demonstrated by previous large randomized trials comparing PCI and CABG might be explained by the use of suboptimal stent technology and by the lack of fractional flow reserve (FFR) guidance of PCI. The objective of this investigator-initiated, multicenter, randomized clinical trial is to investigate whether ...

Tópico(s): Cardiac and Coronary Surgery Techniques

2015 - Elsevier BV | American Heart Journal