Pedro Arriola‐Villalobos, J. Donate-López, C. Calvo-González, J. Reche-Frutos, Nicolás Alejandre‐Alba, David Díaz‐Valle,
Editor, Radiation retinopathy is a potentially severe complication of radiation therapy of ocular, nasal and paranasal malignancies. It is associated with slowly progressive vasculopathy, which may lead to capillary non-perfusion, large vessel occlusion, retinal vascular incompetence, neovascularization and other sequelae (Maguire & Schachat 2001). It has been shown that the radiation dose and the area irradiated are the most important risk factors in the development of this complication (Takeda et ...
Tópico(s): Glaucoma and retinal disorders
2007 - Wiley | Acta Ophthalmologica
Ángel Ortega‐González, Germán Peces-Barba Romero, Itziar Fernández Ormaechea, René Chumbi Flores, Noelia Cubero de Frutos, Nicolás González Mangado,
We compared the use of noninvasive ventilation (NIV) for hypercapnic acidosis with hypoxemia in patients with chronic obstructive pulmonary disease (COPD), obesity hypoventilation syndrome (OHS), or congestive heart failure (CHF) in a respiratory medicine monitoring unit. The objective was to evaluate each diagnostic groups response to therapy in terms of clinical course and evolution of blood gases.Prospective, 12-month study of 53 patients with hypercapnic acidosis with hypoxemia. Twenty-seven patients ...
Tópico(s): Cardiac Arrest and Resuscitation
2006 - Elsevier BV | Archivos de Bronconeumología
Ángel Ortega‐González, Germán Peces-Barba Romero, Itziar Fernández Ormaechea, René Chumbi Flores, Noelia Cubero de Frutos, Nicolás González Mangado,
Hemos realizado un trabajo comparativo en pacientes con enfermedad pulmonar obstructiva crónica (EPOC), síndrome de hipoventilación-obesidad (SHO) e insuficiencia cardíaca congestiva (ICC) sometidos a ventilación no invasiva (VNI) en una unidad de monitorización de neumología por presentar acidosis hipoxémica-hipercápnica. El objetivo ha sido valorar la respuesta clínica y gasométrica en función del diagnóstico. Se trata de un estudio prospectivo (12 meses de duración) en 53 pacientes con acidosis hipoxémicahipercápnica, ...
Tópico(s): Chronic Obstructive Pulmonary Disease (COPD) Research
2006 - Elsevier BV | Archivos de Bronconeumología
Produção Nacional
Revisado por pares
Eva Tejerina, Paolo Pelosi, Alfonso Muriel, Óscar Peñuelas, Yuda Sutherasan, Fernando Frutos‐Vivar, Nicolás Nín, Andrew R. Davies, Fernando Ríos, Damian A. Violi, Konstantinos Raymondos, Javier Hurtado, Marco González, Bin Du, Pravin Amin, Salvatore Maurizio Maggiore, Arnaud W. Thille, Marco Antonio Soares, Manuel Jibaja, Asisclo Villagómez, Michaël Kuiper, Younsuck Koh, Rui P. Moreno, Amine Ali Zeggwagh, Dimitrios Matamis, Antonio Anzueto, Niall D. Ferguson, Martin Dres,
In neurologically critically ill patients with mechanical ventilation (MV), the development of acute respiratory distress syndrome (ARDS) is a major contributor to morbidity and mortality, but the role of ventilatory management has been scarcely evaluated. We evaluate the association of tidal volume, level of PEEP and driving pressure with the development of ARDS in a population of patients with brain injury. We performed a secondary analysis of a prospective, observational study on mechanical ventilation. ...
Tópico(s): Intensive Care Unit Cognitive Disorders
2016 - Elsevier BV | Journal of Critical Care
Javier Nori, Julián N. Lescano, Patricia Illoldi‐Rangel, Nicolás Frutos, Mario Roberto Cabrera, Gerardo C. Leynaud,
Agricultural expansion generates problems to ecosystems and hinders conservation efforts. Although several researchers worldwide are working to develop efficient approaches for conserving biodiversity adequately, certain decisions should be taken urgently. Here, by using two entire classes of vertebrates (amphibians and reptiles), we calculated optimal conservation area networks (CANs) under nine different scenarios (including three different degrees of land-use and three different degrees of ambition ...
Tópico(s): Primate Behavior and Ecology
2013 - Elsevier BV | Biological Conservation
Ximena Porcasi, Camilo H. Rotela, María Virginia Introini, Nicolás Frutos, Sofía Lanfri, Gonzalo Peralta, Estefanía A. De Elia, Mario Lanfri, Carlos Marcelo Scavuzzo,
Based on an agreement between the Ministry of Health and the National Space Activities Commission in Argentina, an integrated informatics platform for dengue risk using geospatial technology for the surveillance and prediction of risk areas for dengue fever has been designed. The task was focused on developing stratification based on environmental (historical and current), viral, social and entomological situation for >3,000 cities as part of a system. The platform, developed with open-source software ...
Tópico(s): COVID-19 epidemiological studies
2012 - PAGEPress (Italy) | Geospatial health
Javier Nori, Mauricio Sebastián Akmentins, Romina Ghirardi, Nicolás Frutos, Gerardo C. Leynaud,
Tópico(s): Genomics and Phylogenetic Studies
2011 - Springer Science+Business Media | Biodiversity and Conservation
Fernando Frutos‐Vivar, Nicolás Nín, Martin Dres,
Purpose of review Acute lung injury (ALI) and acute respiratory distress syndrome (ARDS) are diseases with a significant influence in the public health. A better knowledge of their epidemiology could help to improve the outcome of these diseases. Recent findings Although the clinical criteria of the American-European Consensus Conference definitions for ALI and ARDS are simple, there is a risk of misclassification due to a poor reliability. Except for new emerging infectious diseases, such as severe ...
Tópico(s): Sepsis Diagnosis and Treatment
2004 - Lippincott Williams & Wilkins | Current Opinion in Critical Care
Nicolás Frutos, Leonardo A. Camporro, Luciano Javier Ávila,
RESUMENLiolaemus melanops es un lagarto de mediano tamaño (hasta 90 mm LHC), que habita zonas arenosas bajas y dunas costeras en las provincias argentinas de Río Negro y Chubut.En este estudio se analizó el ámbito de hogar de una población de L. melanops en el centro de Chubut, durante el período febrero a mayo de 2005.En una cuadrícula de 100 x 100 m, todos los individuos observados fueron capturados, sexados, medidos, marcados y liberados en el mismo sitio.Mediante transectas de rumbo fijo, realizadas ...
Tópico(s): Primate Behavior and Ecology
2007 - University of Concepción | Gayana
Nicolás Frutos, Luciana Cecilia Belver,
Tópico(s): Species Distribution and Climate Change
2007 - Asociación Herpetológica Argentina | Cuadernos de herpetología/Cuadernos de herpetología
Cristian Hernán Fulvio Pérez, Nicolás Frutos, Mónica Lilian Kozykariski, Mariana Morando, Daniel Roberto Pérez, Luciano Javier Ávila,
We provide a checklist of lizards distributed in the Rio Negro province, northern Patagonia, Argentina. Representatives of 45 species of lizards were found inhabiting this region as well as several still undescribed species. This list is a contribution to the still poorly known herpetofauna of the region.
Tópico(s): Species Distribution and Climate Change
2011 - Pensoft Publishers | Check List
Pablo Cardinal‐Fernández, Antonio Ferruelo, Mariam El‐Assar, Catalina Santiago, Félix Gómez‐Gallego, Ana Martín-Pellicer, Fernando Frutos‐Vivar, Óscar Peñuelas, Nicolás Nín, Martin Dres, José A. Lorente,
The aim of this study was to demonstrate that candidate gene polymorphisms are associated with an increased risk of acute kidney injury (AKI). Patients admitted to the intensive care unit with the diagnosis of severe sepsis and an expected intensive care unit length of stay more than 48 hours were included. Genetic polymorphisms studied included angiotensin-converting enzyme insertion/deletion (polymerase chain reaction); tumor necrosis factor α − 376, − 308, and − 238; interleukin-8 − 251; vascular endothelial ...
Tópico(s): Erythropoietin and Anemia Treatment
2013 - Elsevier BV | Journal of Critical Care
Pablo Cardinal‐Fernández, Antonio Ferruelo, Mariam El‐Assar, Catalina Santiago, Félix Gómez‐Gallego, Ana Martín-Pellicer, Fernando Frutos‐Vivar, Óscar Peñuelas, Nicolás Nín, Martin Dres, José A. Lorente,
The objective of this study was to analyze the association between candidate gene polymorphisms and susceptibility to acute respiratory distress syndrome (ARDS) in patients with severe sepsis.Patients older than 18 years admitted to the intensive care unit (ICU) with the diagnosis of severe sepsis were prospectively included. A blood sample was drawn on the first day of ICU admission, and DNA was extracted. We genotyped the insertion/deletion polymorphism of the angiotensin-converting enzyme (ACE) ...
Tópico(s): Electrolyte and hormonal disorders
2013 - Lippincott Williams & Wilkins | Shock
Paula C. Escudero, Ignacio Minoli, Nicolás Frutos, Luciano Javier Ávila, Mariana Morando,
Color patterns and melanism have been focus of evolutionary studies in a wide variety of taxa, including lizards, and are often associated with certain ecological attributes. However, within the genus Liolaemus, only some particular aspects of melanism have been studied in a few species of the L. fitzingerii group. Populations of these species show different degrees of melanism with respect to both the intensity and location of black pigment, that in some cases have been used as diagnostic characters ...
Tópico(s): Plant and animal studies
2012 - Asociación Herpetológica Argentina | Cuadernos de herpetología/Cuadernos de herpetología
Produção Nacional
Revisado por pares
Dietger Niederwieser, Helen Baldomero, Yoshiko Atsuta, Mahmoud Aljurf, Adriana Seber, Hildegard Greinix, Mickey Koh, Nina Worel, Sebastián Galeano, Gregorio Jaimovich, Juliana Martínez Rolón, Yoshihisa Kodera, Malek Benakli, Nosa Bazuaye, Cristobal Augusto Frutos Ortiz, Rolandas Gerbutavičius, Alaa Elhaddad, Nicolás Novitzky, Jeff Szer, Jakob Passweg, Nicolaus Kröger, Daniel J. Weisdorf, Marcelo C. Pasquini,
HSCT is the only curative option for many malignant and non-malignant diseases. The WBMT was founded as an umbrella organization of societies involved in cellular therapies with the mission of promoting excellence in HSCT. As a non-governmental organization in official relation with the World Health Organization (WHO), the WBMT assisted in the founding of regional societies (Latin America Blood and Marrow Transplantation Group and African Blood and Marrow Transplantation Group), performs global activity ...
Tópico(s): Telemedicine and Telehealth Implementation
2019 - Elsevier BV | Blood
Luciano Javier Ávila, Nicolás Frutos, Cristian Hernán Fulvio Pérez, Mariana Morando,
Tópico(s): Plant and animal studies
2006 - Pensoft Publishers | Check List
Luciano Javier Ávila, Nicolás Frutos, Mariana Morando, Cristian Hernán Fulvio Pérez, Mónica Lilian Kozykariski,
Tópico(s): Bat Biology and Ecology Studies
2006 - Pensoft Publishers | Check List
Martin Dres, Niall D. Ferguson, Maureen O. Meade, Fernando Frutos‐Vivar, Carlos Apezteguía, Laurent Brochard, Konstantinos Raymondos, Nicolás Nín, Javier Hurtado, Vinko Tomicić, Marco González, José Elizalde, Peter Nightingale, Fekri Abroug, Paolo Pelosi, Yaseen M. Arabi, Rui P. Moreno, Manuel Jibaja, Gabriel D’Empaire, Fredi Sandi, Dimitros Matamis, Ana María Montañez, Antonio Anzueto,
Recent literature in mechanical ventilation includes strong evidence from randomized trials. Little information is available regarding the influence of these trials on usual clinical practice.To describe current mechanical ventilation practices and to assess the influence of interval randomized trials when compared with findings from a 1998 cohort.A prospective international observational cohort study, with a nested comparative study performed in 349 intensive care units in 23 countries. We enrolled ...
Tópico(s): Cardiac Arrest and Resuscitation
2007 - American Thoracic Society | American Journal of Respiratory and Critical Care Medicine
Óscar Peñuelas, Alfonso Muriel, Fernando Frutos‐Vivar, Eddy Fan, Konstantinos Raymondos, Fernando Ríos, Nicolás Nín, Arnaud W. Thille, Marco González, Asisclo Villagómez, Andrew R. Davies, Bin Du, Salvatore Maurizio Maggiore, Dimitrios Matamis, Fekri Abroug, Rui P. Moreno, Michaël Kuiper, Antonio Anzueto, Niall D. Ferguson, Martin Dres,
Background: Intensive care unit-acquired paresis (ICUAP) is associated with poor outcomes. Our objective was to evaluate predictors for ICUAP and the short-term outcomes associated with this condition. Methods: A secondary analysis of a prospective study including 4157 mechanically ventilated adults in 494 intensive care units from 39 countries. After sedative interruption, patients were screened for ICUAP daily, which was defined as the presence of symmetric and flaccid quadriparesis associated ...
Tópico(s): Sepsis Diagnosis and Treatment
2016 - SAGE Publishing | Journal of Intensive Care Medicine
Nicolás Nín, Raúl Lombardi, Fernando Frutos‐Vivar, Martin Dres, José A. Lorente, Niall D. Ferguson, Javier Hurtado, Carlos Apezteguía, Laurent Brochard, Frédérique Schortgen, Konstantinos Raymondos, Vinko Tomicić, Luis Soto, Marco González, Peter Nightingale, Fekri Abroug, Paolo Pelosi, Yaseen M. Arabi, Rui P. Moreno, Antonio Anzueto,
Emerging evidence suggests that minor changes in serum creatinine concentrations are associated with increased hospital mortality rates. However, whether serum creatinine concentration (SCr) on admission and its change are associated with an increased mortality rate in mechanically ventilated patients is not known. We have conducted an international, prospective, observational cohort study enrolling adult intensive care unit patients under mechanical ventilation (MV). Recursive partitioning was used ...
Tópico(s): Acute Kidney Injury Research
2010 - Lippincott Williams & Wilkins | Shock
Alfonso Muriel, Óscar Peñuelas, Fernando Frutos‐Vivar, Alejandro C. Arroliga, Víctor Abraira, Arnaud W. Thille, Laurent Brochard, Nicolás Nín, Andrew R. Davies, Pravin Amin, Bin Du, Konstantinos Raymondos, Fernando Ríos, Damian A. Violi, Salvatore Maurizio Maggiore, Márcio Soares, Marco González, Fekri Abroug, Hans-Henrik Bülow, Javier Hurtado, Michaël Kuiper, Rui P. Moreno, Amine Ali Zeggwagh, Asisclo Villagómez, Manuel Jibaja, Luis Soto, Gabriel D’Empaire, Dimitrios Matamis, Younsuck Koh, Antonio Anzueto, Niall D. Ferguson, Martin Dres,
There are limited data available about the role of sedation and analgesia during noninvasive positive pressure ventilation (NPPV). The objective of study was to estimate the effect of analgesic or sedative drugs on the failure of NPPV. We studied patients who received at least 2 h of NPPV as first-line therapy in a prospective observational study carried out in 322 intensive care units from 30 countries. A marginal structural model (MSM) was used to analyze the association between the use of analgesic ...
Tópico(s): Family and Patient Care in Intensive Care Units
2015 - Springer Science+Business Media | Intensive Care Medicine
Raúl Lombardi, Nicolás Nín, José A. Lorente, Fernando Frutos‐Vivar, Niall D. Ferguson, Javier Hurtado, Carlos Apezteguía, Pablo Desmery, Konstantinos Raymondos, Vinko Tomicić, Nahit Çakar, Marco González, José Elizalde, Peter Nightingale, Fekri Abroug, Manuel Jibaja, Yaseen M. Arabi, Rui P. Moreno, Dimitros Matamis, Antonio Anzueto, Martin Dres,
The aim of our study was to assess the new diagnostic criteria of acute kidney injury (AKI) proposed by the Acute Kidney Injury Network (AKIN) in a large cohort of mechanically ventilated patients.This is a prospective observational cohort study enrolling 2783 adult intensive care unit patients under mechanical ventilation (MV) with data on serum creatinine concentration (SCr) in the first 48 hours. The absolute and the relative AKIN diagnostic criteria (changes in SCr ≥ 0.3 mg/dl or ≥ 50% over the first ...
Tópico(s): Cardiac Arrest and Resuscitation
2011 - Lippincott Williams & Wilkins | Clinical Journal of the American Society of Nephrology
Fernando Frutos‐Vivar, Martin Dres, Nicolás Nín,
Tópico(s): Sepsis Diagnosis and Treatment
2005 - Elsevier BV | Archivos de Bronconeumología
Óscar Peñuelas, Fernando Frutos‐Vivar, Cristina Fernández, Antonio Anzueto, Scott K. Epstein, Carlos Apezteguía, Marco González, Nicolás Nín, Konstantinos Raymondos, Vinko Tomicić, Pablo Desmery, Yaseen M. Arabi, Paolo Pelosi, Michaël Kuiper, Manuel Jibaja, Dimitros Matamis, Niall D. Ferguson, Martin Dres,
Rationale: A new classification of patients based on the duration of liberation of mechanical ventilation has been proposed.Objectives: To analyze outcomes based on the new weaning classification in a cohort of mechanically ventilated patients.Methods: Secondary analysis included 2,714 patients who were weaned and underwent scheduled extubation from a cohort of 4,968 adult patients mechanically ventilated for more than 12 hours.Measurements and Main Results: Patients were classified according to ...
Tópico(s): Family and Patient Care in Intensive Care Units
2011 - American Thoracic Society | American Journal of Respiratory and Critical Care Medicine
Martin Dres, Fernando Frutos‐Vivar, Alfonso Muriel, Niall D. Ferguson, Óscar Peñuelas, Víctor Abraira, Konstantinos Raymondos, Fernando Ríos, Nicolás Nín, Carlos Apezteguía, Damian A. Violi, Arnaud W. Thille, Laurent Brochard, Marco González, Asisclo Villagómez, Javier Hurtado, Andrew R. Davies, Bin Du, Salvatore Maurizio Maggiore, Paolo Pelosi, Luis Soto, Vinko Tomicić, Gabriel D’Empaire, Dimitrios Matamis, Fekri Abroug, Rui P. Moreno, Marco Antonio Soares, Yaseen M. Arabi, Freddy Sandi, Manuel Jibaja, Pravin Amin, Younsuck Koh, Michaël Kuiper, Hans‐Henrik Bülow, Amine Ali Zeggwagh, Antonio Anzueto,
Baseline characteristics and management have changed over time in patients requiring mechanical ventilation; however, the impact of these changes on patient outcomes is unclear.To estimate whether mortality in mechanically ventilated patients has changed over time.Prospective cohort studies conducted in 1998, 2004, and 2010, including patients receiving mechanical ventilation for more than 12 hours in a 1-month period, from 927 units in 40 countries. To examine effects over time on mortality in ...
Tópico(s): Cardiac Arrest and Resuscitation
2013 - American Thoracic Society | American Journal of Respiratory and Critical Care Medicine
Xiao‐jun Wang, Rogelio P. Frutos, Li Zhang, Xiufeng Sun, Yibo Xu, Thomas Wirth, Thomas Nicola, Lawrence J. Nummy, Dhileep Krishnamurthy, Carl A. Busacca, Nathan K. Yee, Chris H. Senanayake,
The synthesis of LFA-1 inhibitor BIRT2584 on metric-ton scale was accomplished by means of a safe and robust process. Highlights of the process include the asymmetric synthesis of the key advanced intermediate by implementation of Seebach’s self-regeneration of stereocenters principle, and a Ph3PCl2-induced dehydration of a critical urea followed by a regioselective bromination to give the elaborated 1H-imidazo[1,2-a]imidazol-2-one. A sulfonyl chloride intermediate was produced through Br/Mg exchange ...
Tópico(s): Cell Adhesion Molecules Research
2011 - American Chemical Society | Organic Process Research & Development
Los cambios en la economia mexicana ocurridos durante los quince ultimos anos han tenido profundas repercusiones en la organizacion del territorio a escala nacional y regional; trastornaron tambien las economias urbanas: un fuerte crecimiento demografico y economico de las ciudades medias, la reestructuracion economicas de las metropolis son algunas de sus consecuencias. Dichas transformaciones dejan tambien entrever la posibilidad de profundas modificaciones de los sistemas sociales y, entre otros, ...
Tópico(s): Latin American Urban Studies
1999 - Pontifical Catholic University of Chile | EURE (Santiago)
Produção Nacional
Revisado por pares
José A. Lorente, Pablo Cardinal‐Fernández, Diego Muñoz, Fernando Frutos‐Vivar, Arnaud W. Thille, Carlos Jaramillo, Aída Ballén-Barragán, José Manuel Vázquez‐Rodríguez, Óscar Peñuelas, Guillermo Ortíz, José Ramón Blanco, Bruno Valle Pinheiro, Nicolás Nín, Maria del Carmen Marín, Martin Dres, Bruce Thompson,
Tópico(s): Neonatal Respiratory Health Research
2015 - Springer Science+Business Media | Intensive Care Medicine
Breni María Posadas-Herrera, Pedro Antonio López, Nicolás Gutiérrez-Rangel, Rufino Díaz-Cervantes, Armando Ibáñez-Martínez,
El manzano (Malus spp.) es un frutal distribuido mundialmente, con más de 30 especies y casi 1000 variedades. El municipio de Zacatlán, ubicado en la Sierra Norte de Puebla, México, es el principal productor en el estado y se le reconoce por su tradición en el cultivo y aprovechamiento de este frutal, así como por la abundancia y variabilidad de cultivares, destacando los ‘locales’ o ‘tradicionales’. No obstante, esta diversidad regional no ha sido caracterizada; por ello, este estudio tuvo como objetivo ...
Tópico(s): Botanical Research and Applications
2018 - Mexican Society of Phytogenetics | Revista Fitotecnia Mexicana
Produção Nacional
Revisado por pares
Eva Tejerina, Paolo Pelosi, Chiara Robba, Óscar Peñuelas, Alfonso Muriel, Deisy Barrios, Fernando Frutos‐Vivar, Konstantinos Raymondos, Bin Du, Arnaud W. Thille, Fernando Ríos, Marco González, Lorenzo del-Sorbo, Maria del Carmen Marín, Bruno Valle Pinheiro, Marco Antonio Soares, Nicolás Nín, Salvatore Maurizio Maggiore, Andrew D. Bersten, Pravin Amin, Nahit Çakar, Gee Young Suh, Fekri Abroug, Manuel Jibaja, Dimitros Matamis, Amine Ali Zeggwagh, Yuda Sutherasan, Antonio Anzueto, Martin Dres,
To describe the changes in ventilator management over time in patients with neurologic disease at ICU admission and to estimate factors associated with 28-day hospital mortality.Secondary analysis of three prospective, observational, multicenter studies.Cohort studies conducted in 2004, 2010, and 2016.Adult patients who received mechanical ventilation for more than 12 hours.None.Among the 20,929 patients enrolled, we included 4,152 (20%) mechanically ventilated patients due to different neurologic ...
Tópico(s): Intracerebral and Subarachnoid Hemorrhage Research
2021 - Lippincott Williams & Wilkins | Critical Care Medicine