Giles Smith, Andrew Robson, Matt Dickinson Chief Sports Correspondent, Janice Turner, Gabriele Marcotti, Christina Hardyment, Alexi Mostrous, Roy Collins, Barry Hearn, Richard Whitehead, Robert Cole, David Brown, Patrick Foster Media Correspondent, Alice Bowe, Zahid Hussain, Mike Finlay, Frances Gibb Legal Editor, Amanda Ursell, Simon Barnes, Jane MacQuitty, Frank Pope Ocean Correspondent, Robert Vincent, Peter Lansley, Ashling O'Connor Olympics Correspondent, Maxine Peake, Simon Hills, Nick Bradshaw, Robert Lindsay, Mark Souster, John Mulvey, T. S. Allen, Grant Thatcher, Sarah Urwin Jones, Emma Cook, Michael Atherton, Mike Harvey, Philip Howard, David J. Finney, Carol Midgley, Adam Nicolson, David Chater, Michael Binyon, Kate Wighton, Rachel Campbell-Johnston, Melissa Katsoulis, Clive Davis, Michael Schmidt, Gráinne Gilmore Economics Correspondent, Graham Stewart, Jane Taylor-Hayhurst, Wendy Ide, John Bungey, Joanna Sugden, Sam Banik, Martin Vlietstra, Giles Coren, Alastair Campbell, Martin Fletcher, Sathnam Sanghera, Ben Webster Transport Correspondent, Sean O'Neill Crime Editor, Dr Copperfield, Valerie Elliott Countryside Editor, John Arlidge, A. C. Grayling, Stephen McClarence, Jane MacArtney, Rob Crilly, Valerie Elliott, Stephen Taylor, Rachel Sylvester, John Clarke, Robert M. Bruce-Chwatt, Jane Whiter, Deborah Haynes, Jane Halliday, Dominic Walsh, Tom Bawden, Debra Craine, Tim Travers, Joe Swift, Tom Charity, Allan Simmons, John Sergeant, Tim Reid, Daniel Finkelstein, Ruth Gledhill Religion Correspondent, Bebeto Matthews, David Kavanagh, Tom Gatti, David Sharrock Ireland Correspondent, Helena Pozniak, Robin Catherwood, Graham Baldwin, C. D. C. Armstrong, Andrew Ellson Personal Finance Editor, David Hands, Charles Bremner, Caroline White, Ron Lewis, David Findlay, Jonathan Sacks, Greg Hurst, Lucy Sweeney, David Charter, Lilly Peel, Tim Teeman, Dennis Witcombe, Dominic Kennedy Investigations Editor, Patrick Heren, Derwent May, Bruce Parker, Kate Muir, James Mottram, Richard Hobson Deputy Cricket Correspondent, Russell Kempson, Peter Paphides, Vanora Bennett, The Rev Dr Andrew, Tom Whitwell, Ed Potton, Suzy Jagger, Oliver Kay, Lisa Freedman, Trevor Johnston, Stephen Anderton, Russell Vallance, Sarah Vine, Mark Atherton, Lisa Armstrong, John Westerby, Rick Broadbent, Tom Baldwin, Scott Rutherford, John Hopkins, Sally Baker, Richard Lichten, Douglas Rankine, David Baddiel, Pete Paphides, Simon de Bruxelles, Rob Wright, ZoË Strimpel, Christina Koning, Neil Harman Tennis Correspondent, Anne Barrowclough, Raymond Keene, Christine Buckley, Suzi Godson, Matthew Pryor, Kate Saunders, Catherine Philp Diplomatic Correspondent, Christine Buckley Industrial Editor, Ivar Amundsen, Kaveh Solhekol, Laura Ivill, Roger Phillips, Jeremy Page, Rick Jones, Chris Campling, Alice Thomson, Dr M. Gullan-Whur, Patrick Hosking, Susan Kelly, Marcus Leroux, Rebecca O'connor, Roy Hyde, Erica Wagner, Marcel Berlins, Ross Leckie, James Charles, Nick Hasell, Thomasina Miers, Margaret Reynolds, David Hands Rugby Correspondent, W. F. Kerswell, Kevin Maher, Paul Simons, Michael Herman, Nicholas Clee, Nancy Durrant, Nigel Kendall, Nick Szczepanik, Abbie Jones, Joanna Pitman, Dearbáil Jordan, Dave Stewart, Philip Webster Political Editor, Richard Ehrlich, Mike Ashley, Andy Zaltzman, Ian King Deputy Business Editor, Robert Crampton, Harriet Addison, Dominic Maxwell, Alice Fordham, Prue White, Matthew Parris, Mark Bridge, Joanne Sim, Helen Power, Amanda Craig, George Caulkin, Tim Wapshott, Russell Jenkins, Caitlin Moran, Sheila Keating, Neil Fisher, Iain Finlayson, Ben MacIntyre, Sarah Ebner, Joe Clay, John Naish, Michael Horovitz, Lewis Stuart, Martin Waller, Mark Henderson, Lewis Smith Environment Reporter, Chris Ayres, Dan Hughes, Captain Nigel Palmer, Kathleen Wyatt, Carl Mortished World Business Editor, Louise Cohen, Benedict Nightingale, Stephen Dalton, Bob Mankoff, Leo Lewis, Alyson Rudd, Frances Gibb, Richard Morrison, Tony Halpin, John Bradfield, Geoff Watson, David Budworth, Adam Sherwin, James Christopher, Simon Crompton, Ahdaf Soueif, Alan Lee Racing Correspondent, Ian Stewart, Kim Newman, Miles Costello, Fiona Hamilton, Andrew Dow, Priya Elan,
... 18,89min Stars: Jennifer Carpenter, Steve Harris, Jay Hernandez On general release Choke Director: Clark Gregg, 18, ...
2008 - Gale Group | TDA
Isaac Ehrlich, Gary S. Becker,
... org/10.1007/s10640-020-00429-wSarah Bensalem, Nicolás Hernández Santibáñez, Nabil Kazi-Tani Prevention efforts, insurance demand ...
Tópico(s): Taxation and Compliance Studies
1972 - University of Chicago Press | Journal of Political Economy
J. Nicolás Hernández, Miguel Á. Ramírez, Victor S. Martı́n,
A mild and new procedure for the selective cleavage of an alkoxycarbonyl group (Boc, CBz) in N,N-dicarbamoyl-protected amino compounds is described. The method is based on the use of lithium bromide in acetonitrile and is compatible with a large range of other functionalities present in the substrates. Compared with other reported methodologies, the procedure is particularly useful for the Cbz-selective cleavage in N,N-Ts,Cbz-diprotected amines. A rationalization of the selectivity supported by ab ...
Tópico(s): Coordination Chemistry and Organometallics
2002 - American Chemical Society | The Journal of Organic Chemistry
A.J. Sánchez‐Herencia, Nicolás Hernández, Rodrigo Moreno,
A strong effort has been devoted recently toward processing of metal–ceramic composites with tailored microstructure by colloidal methods. The aim of this work is to optimize the rheological behavior of concentrated Al 2 O 3 –nickel (Ni) aqueous suspensions and further slip casting in order to obtain dense green composites. Compositions with Ni relative contents ranging from 5 to 75 vol% were prepared from suspensions with high solids loadings (50 vol%) by adjusting the colloidal stability of each ...
Tópico(s): Polymer Surface Interaction Studies
2006 - Wiley | Journal of the American Ceramic Society
Nicolás Hernández, Rodrigo Moreno, A.J. Sánchez‐Herencia, J.L.G. Fierro,
The colloidal behavior of nickel aqueous suspensions is studied and compared to that of NiO suspensions. Under acidic conditions, nickel readily dissolves, but no dissolution takes place at basic pH. Zeta potential is studied as a function of pH, showing that the isoelectric point (IEP) occurs at pH 3.5-4. Above the IEP there is a zeta potential plateau, which is associated to the predominance of NiO(OH) species. At pH 9 a new decrease in zeta potential is associated to NiO predominance. XPS studies ...
Tópico(s): Electrochemical Analysis and Applications
2005 - American Chemical Society | The Journal of Physical Chemistry B
J. Nicolás Hernández, Victor S. Martı́n,
The consecutive treatment of N-Cbz amino protected compounds with LiHMDS and CbzCl provides a practical method for the preparation of N,N-benzyloxycarbamoyl (N,N-di-Cbz) derivatives in good yield. When alpha-amino acids are used the protection occurs without racemization. The method is compatible with a wide range of other functional and protecting groups. The procedure is also valid for the synthesis of mixed N,N-carbamoyl derivatives.
Tópico(s): Organophosphorus compounds synthesis
2004 - American Chemical Society | The Journal of Organic Chemistry
Juan M. López‐Soria, Sixto J. Pérez, J. Nicolás Hernández, Miguel Á. Ramírez, Victor S. Martı́n, Juan I. Padrón,
A selective, catalytic and practical method for removing a Boc group from several N , N ′-diprotected amino acids and amine derivatives using iron( iii ) salts as sustainable catalysts is described.
Tópico(s): Chemical Synthesis and Reactions
2014 - Royal Society of Chemistry | RSC Advances
Carlos Ayala‐Torres, Nicolás Hernández, Alejandra Galeano, Lorena Novoa‐Aponte, Carlos‐Y. Soto,
The surface charge of bacteria is closely related to their envelope structure and interactions with surfaces in natural environments. The aim of this study was to estimate the effect of experimental conditions on the zeta (ζ) potential of mycobacterial cells as a measure of their cell-surface charge. We observed that Mycobacterium smegmatis mc2155 cells at physiological conditions displayed a high and stable ζ potential (−42.9 ± 5.9 mV) which increased from the late-exponential phase of growth and at ...
Tópico(s): Bacterial biofilms and quorum sensing
2013 - BioMed Central | Annals of Microbiology
Nicolás Hernández, Victor S. Martı́n,
ADVERTISEMENT RETURN TO ISSUEPREVNoteNEXTGeneral Stereoselective Synthesis of Chemically Differentiated α-Diamino Acids: Synthesis of 2,6-Diaminopimelic and 2,7-Diaminosuberic AcidsNicolás Hernández and Víctor S. MartínView Author Information Instituto Universitario de Bio-Orgánica "Antonio González", Universidad de La Laguna, C/Astrofísico Francisco Sánchez, 2, 38206 La Laguna, Tenerife, Spain [email protected]Cite this: J. Org. Chem. 2001, 66, 14, 4934–4938Publication Date (Web):June 9, 2001Publication ...
Tópico(s): Chemical Synthesis and Analysis
2001 - American Chemical Society | The Journal of Organic Chemistry
Gerardo Martínez‐Aguilar, Carmen J. Serrano, Julio Enrique Castañeda‐Delgado, N. Macías-Segura, Nicolás Hernández-Delgadillo, Leonor Enciso‐Moreno, Yolanda García de Lira, Ema Valenzuela-Méndez, Benjamín Gándara-Jasso, Joel Correa-Chacón, Yadira Bastián, Martha Rodríguez-Morán, Fernando Guerrero-Romero, José Antonio Enciso‐Moreno,
Type 2 diabetes mellitus (DM2) confers a higher risk for active tuberculosis (TB). However, information on associated risk factors for latent tuberculosis infection (LTBI) inpatients with DM2 is limited. We conducted a cross-sectional study to elucidate the prevalence of LTBI and its associated factors on Mexican adults with DM2 receiving medical care at the Mexican Social Security Institute (IMSS).Six hundred patients with DM2 without a prior history of TB from outpatient diabetes clinics were enrolled ...
Tópico(s): Diagnosis and treatment of tuberculosis
2015 - Elsevier BV | Archives of Medical Research
Clément Delmas, Aemilia Jacquemin, Fanny Vardon‐Bounes, Bernard Georges, Felipe Guerrero, Nicolás Hernández, Bertrand Marcheix, Thierry Seguin, Vincent Minville, Jean‐Marie Conil, Stein Silva,
Purpose: Extra Corporeal Membrane Oxygenation (ECMO) is used in cases of severe respiratory and/or circulatory failure over periods of several days to several weeks. Its circuitry requires a closely monitored anticoagulation therapy that is empirically supported by activated clotting time (ACT)—a method often associated with large inter- and intraindividual variability. We aimed to compare the measurement of heparin activity with ACT and the direct measurement of the heparin activity (anti-Xa) in a ...
Tópico(s): Heart Failure Treatment and Management
2018 - SAGE Publishing | Journal of Intensive Care Medicine
Nicolás Hernández, Andrés Fuentes, Pedro Reszka, A. Carlos Fernandez‐Pello,
The theory to predict ignition of solid fuels exposed to incident radiant heat fluxes has permitted to obtain simple correlations of the ignition delay time with the incident heat flux which are useful in practical engineering applications. However, the theory was developed under the assumption that radiation does not penetrate into the solid phase. In the case of semi-transparent solids, where the penetration of radiation plays an important role in the heating and subsequent ignition of the fuel, ...
Tópico(s): Fire dynamics and safety research
2018 - Elsevier BV | Proceedings of the Combustion Institute
Aitor Rizo-Liendo, Inés Sifaoui, María Reyes‐Batlle, Olfa Chiboub, Rubén L. Rodríguez-Expósito, Carlos J. Bethencourt-Estrella, Desirée San Nicolás-Hernández, Edyta B. Hendiger, Atteneri López‐Arencibia, Pedro Rocha-Cabrera, José E. Piñero, Jacob Lorenzo‐Morales,
Naegleria fowleri causes a deadly disease called primary amoebic meningoencephalitis (PAM). Even though PAM is still considered a rare disease, the number of reported cases worldwide has been increasing each year. Among the factors to be considered for this, awareness about this disease, and also global warming, as these amoebae thrive in warm water bodies, seem to be the key factors. Until present, no fully effective drugs have been developed to treat PAM, and the current options are amphotericin ...
Tópico(s): Amoebic Infections and Treatments
2019 - Multidisciplinary Digital Publishing Institute | Pathogens
Atteneri López‐Arencibia, Desirée San Nicolás-Hernández, Carlos J. Bethencourt-Estrella, Inés Sifaoui, María Reyes‐Batlle, Rubén L. Rodríguez-Expósito, Aitor Rizo-Liendo, Jacob Lorenzo‐Morales, Isabel L. Bazzocchi, José E. Piñero, Ignacio A. Jiménez,
Leishmaniasis and American trypanosomiasis are parasitic diseases that cause significant clinical, social and economic impact on the population of tropical and subtropical countries. Their current treatment is limited and presents multiple drawbacks, including high toxicity, high cost, lengthy treatment plans, as well as the emergence of resistant species. Therefore, there is a need to find new lead compounds with high potency against parasites and low toxicity in patients. In the present work, ...
Tópico(s): Nanoparticles: synthesis and applications
2019 - Multidisciplinary Digital Publishing Institute | Pathogens
Edyta B. Hendiger, Marcin Padzik, Inés Sifaoui, María Reyes‐Batlle, Atteneri López‐Arencibia, Aitor Rizo-Liendo, Carlos J. Bethencourt-Estrella, Desirée San Nicolás-Hernández, Olfa Chiboub, Rubén L. Rodríguez-Expósito, Marta Grodzik, Anna Pietruczuk-Padzik, Karolina Stępień, Gabriela Olędzka, Lidia Chomicz, José E. Piñero, Jacob Lorenzo‐Morales,
Free living, cosmopolitan amoebae from Acanthamoeba genus present a serious risk to human health. As facultative human parasites, these amoebae may cause Acanthamoeba keratitis (AK). Acanthamoeba keratitis is a severe, vision-threatening corneal infection with non-specific symptoms. The number of reported AK cases worldwide has been increasing every year. Moreover, 90% of Acanthamoeba keratitis cases are related to contact lens use. Wearing and storage contact lenses not in accordance with the physicians ...
Tópico(s): Ocular Infections and Treatments
2020 - Multidisciplinary Digital Publishing Institute | Pathogens
Luis Cartuche, Inés Sifaoui, Atteneri López‐Arencibia, Carlos J. Bethencourt-Estrella, Desirée San Nicolás-Hernández, Jacob Lorenzo‐Morales, José E. Piñero, Ana R. Díaz‐Marrero, José J. Fernández,
Chagas disease and leishmaniasis are neglected tropical diseases caused by kinetoplastid parasites of Trypanosoma and Leishmania genera that affect poor and remote populations in developing countries. These parasites share similar complex life cycles and modes of infection. It has been demonstrated that the particular group of phosphorylating enzymes, protein kinases (PKs), are essential for the infective mechanisms and for parasite survival. The natural indolocarbazole staurosporine (STS, 1) has ...
Tópico(s): Phytochemical compounds biological activities
2020 - Multidisciplinary Digital Publishing Institute | Biomolecules
José Ignacio Rivera, Nicolás Hernández, Jean-Louis Consalvi, Pedro Reszka, Jorge Lotero Contreras, Andrés Fuentes,
Experiments were carried out in the Idealized-Firebrand Ignition Test (I-FIT), a bench scale apparatus specifically designed to test the ignition of forest fuel layers from a representative firebrand. A cylindrical heater was used to model the firebrand, which allowed to control the incident radiative heat flux on the specimen, from the critical heat flux up to 25 kW/m2, for five different porosities of the fuel layer. Experimental ignition delay times were interpreted based on a theoretical model ...
Tópico(s): Combustion and flame dynamics
2020 - Elsevier BV | Fire Safety Journal
Nicolás Hernández, Jana Soenksen, Paul J. Newcombe, Manjinder S. Sandhu, Inês Barroso, Chris Wallace, Jennifer L. Asimit,
Abstract Joint fine-mapping that leverages information between quantitative traits could improve accuracy and resolution over single-trait fine-mapping. Using summary statistics, flashfm (flexible and shared information fine-mapping) fine-maps signals for multiple traits, allowing for missing trait measurements and use of related individuals. In a Bayesian framework, prior model probabilities are formulated to favour model combinations that share causal variants to capitalise on information between ...
Tópico(s): Advanced Causal Inference Techniques
2021 - Nature Portfolio | Nature Communications
Nicolás Hernández, Danielle Endres,
As we write this, California is being ravaged by the second worst wildfire in its history (Dixie) and our fellow Utahns have experienced some of the world's worst air quality due, in part, to the smoke traveling east from the Dixie and other fires in the west. These consequences are just a few of the many ways in which the ongoing climate crisis is a threat multiplier: worsening extreme weather, droughts, wildfires, and, most significantly, the disproportionate inequities historically marginalized ...
Tópico(s): Ecocriticism and Environmental Literature
2022 - Michigan State University | Rhetoric and Public Affairs
Nicolás Hernández, Andrés Fuentes, Jean-Louis Consalvi, J.C. Elicer-Cortés,
The spontaneous ignition of a forest fuel layer by idealized firebrands was carried out experimentally in a bench scale apparatus designed to understand the relationship between the time to ignition and incident radiative heat flux on a ring-shaped forest fuel litter. Time to ignition, mass loss, radial temperatures and incident radiative heat flux were measured. The fuel samples were Radiata Pine needles, representative of Chilean forests and the influence of the physical characteristics of the ...
Tópico(s): Thermochemical Biomass Conversion Processes
2018 - Elsevier BV | Experimental Thermal and Fluid Science
Inés Sifaoui, María Reyes‐Batlle, Atteneri López‐Arencibia, Olfa Chiboub, Carlos J. Bethencourt-Estrella, Desirée San Nicolás-Hernández, Rubén L. Rodríguez-Expósito, Aitor Rizo-Liendo, José E. Piñero, Jacob Lorenzo‐Morales,
Acanthamoeba are free living amoeba that have been isolated from different environments like soil, water, air dust. Moreover, they are also able to act as opportunist pathogens, mainly causing a fatal encephalitis and also keratitis in both human and animals. This study was aimed to evaluate the activity of the Medicines for Malaria Venture (MMV) compounds against the trophozoite stage of Acanthamoeba castellanii Neff. Sixteen compounds showed ≥90% inhibition of parasite growth in the initial screen ( ...
Tópico(s): Bacillus and Francisella bacterial research
2019 - Elsevier BV | Experimental Parasitology
Nicolás Hernández, Rodolphe Sonnier, Stéphane Giraud,
The flammability of nine polypropylene fabrics or sheets has been tested using cone calorimeter at various heat fluxes (25, 35, 50, and 75 kW/m 2 ) in order to assess the relevance of this fire test for thermally thin materials. The chosen procedure uses a grid and allows maintaining a constant exposed surface during the test, except for the lightest fabric. The structure of the knitted fabrics has a relatively small influence on the main flammability parameters. On the contrary, the area density of ...
Tópico(s): Combustion and Detonation Processes
2017 - SAGE Publishing | Journal of Fire Sciences
Andrés González-Guerra, Marta Roche-Molina, Nieves García-Quintáns, Cristina Sánchez‐Ramos, Daniel Martín-Pérez, Mariya Lytvyn, Javier de Nicolás‐Hernández, José Rivera, Diego F. Arroyo, David Sanz‐Rosa, Juan A. Bernal,
The continuous relationship between blood pressure (BP) and cardiovascular events makes the distinction between elevated BP and hypertension based on arbitrary cut-off values for BP. Even mild BP elevations manifesting as high-normal BP have been associated with cardiovascular risk. We hypothesize that persistent elevated BP increases atherosclerotic plaque development. To evaluate this causal link, we developed a new mouse model of elevated BP based on adeno-associated virus (AAV) gene transfer. ...
Tópico(s): Cardiovascular Health and Disease Prevention
2021 - Multidisciplinary Digital Publishing Institute | International Journal of Molecular Sciences
Rodrigo Donoso, Álvaro Rodríguez, Karim Esteffan, Claudio Lagos C, Diego Aránguiz, Nicolás Hernández,
Background Purpose To evaluate Pentacam and OPD-Scan parameters in the early detection of keratoconus. Design Retrospective case-control study. Methods Case group included 50 clinically unaffected fellow eyes diagnosed with asymmetric keratoconus showing subtle qualitative changes at the 0.5-D sensitivity OPD-Scan scale, as well as normal anterior and back elevation difference map at Belin/Ambrósio enhanced ectasia display (BAD) at the Pentacam. Control group included 172 normal eyes that underwent ...
Tópico(s): Corneal Surgery and Treatments
2021 - Elsevier BV | American Journal of Ophthalmology
Carlos J. Bethencourt-Estrella, Nathália Nocchi, Atteneri López‐Arencibia, Desirée San Nicolás-Hernández, Marı́a L. Souto, Blanca Suárez‐Gómez, Ana R. Díaz‐Marrero, José J. Fernández, Jacob Lorenzo‐Morales, José E. Piñero,
Leishmaniasis and Chagas disease are neglected tropical diseases that cause problems in developing countries. The causative agents, Leishmania spp. and Trypanosoma cruzi, produce a clinical picture that can be fatal for the patient, such as Chagas heart disease, visceral leishmaniasis and megacolon, among others. Current treatments for these diseases are not very effective and highly toxic, since they require very prolonged treatments. The development of innovative, effective and safe drugs to fight ...
Tópico(s): Insect Pest Control Strategies
2021 - Multidisciplinary Digital Publishing Institute | Pharmaceuticals
J. Nicolás Hernández, Miguel Á. Ramírez, M.L. Rodríguez, Victor S. Martı́n,
The intramolecular Nicholas reaction of propargylic alcohols derived from N,N-acyl-diprotected ω-semialdehydes obtained from glutamic acid provided stereoselectively 5-alkynylproline derivatives. The suitable choice of the N-protecting group (tosyl or benzoyl derivative) permitted control of the stereochemistry during the ring formation. Semiempirical calculations of the species involved in the cyclization support the observed stereochemistry.
Tópico(s): Catalytic Alkyne Reactions
2008 - American Chemical Society | Organic Letters
Nicolás Hernández-Santibán͂ez, Thibaut Mastrolia,
In this paper we investigate a Principal-Agent problem with moral hazard under Knightian uncertainty. We extend the seminal framework of Holmström and Milgrom by combining a Stackelberg equilibrium with a worst-case approach. We investigate a general model in the spirit of [J. Cvitanić, D. Possamaï, and N. Touzi, Management Sci., 63 (2016), pp. 3328--3346], [J. Cvitanić, D. Possamaï, and N. Touzi, Finance Stoch., 22 (2018), pp. 1--37]. We show that optimal contracts depend on the output and its quadratic ...
Tópico(s): Climate Change Policy and Economics
2019 - Society for Industrial and Applied Mathematics | SIAM Journal on Control and Optimization
Carlos J. Bethencourt-Estrella, Samuel Delgado‐Hernández, Atteneri López‐Arencibia, Desirée San Nicolás-Hernández, Inés Sifaoui, David Tejedor, Fernando García‐Tellado, Jacob Lorenzo‐Morales, José E. Piñero,
The neglected infection known as Chagas disease, caused by the protozoan parasite Trypanosoma cruzi, results in more than 7000 deaths per year, with an increasing number of cases in non-endemic areas such as Europe or the United States. Moreover, with the current available therapy, only two compounds which are active against the acute phase of the disease are readily available. In addition, these therapeutic agents display multiple undesired side effects such as high toxicity, they are expensive, ...
Tópico(s): Synthesis and Biological Evaluation
2021 - Multidisciplinary Digital Publishing Institute | Pharmaceuticals
Carlos J. Bethencourt-Estrella, Samuel Delgado‐Hernández, Atteneri López‐Arencibia, Desirée San Nicolás-Hernández, David Tejedor, Fernando García‐Tellado, Jacob Lorenzo‐Morales, José E. Piñero,
Leishmaniasis produces approximately-one million of new cases annually, making it one of the most important tropical diseases. As current treatments are not fully effective and are toxic, it is necessary to develop new therapies that are more effective and less toxic, and cause a controlled cell death, with which we can avoid the immunological problems caused by necrosis. In this work 32 acrylonitriles were studied in vitro against Leishmania amazonensis. Three compounds Q20 (12.41), Q29 (11.2) and ...
Tópico(s): Synthesis and Biological Evaluation
2022 - Elsevier BV | Bioorganic Chemistry
J. Nicolás Hernández, Fernando R. Pinacho Crisóstomo, Tomás Martı́n, Victor S. Martı́n,
Abstract A new, practical, and mild procedure for the selective cleavage of a tert ‐butoxycarbonyl group (Boc) in N ‐Boc‐ N ‐acyl‐diprotected amines is described. When applied to α‐amino acids, complete integrity of the stereochemistry was observed. The use of N , N ‐di‐Boc‐α‐amino‐δ‐ and γ‐hydroxy esters provided both δ‐ and γ‐lactones in very good yields. The method is based on the use of Montmorillonite K‐10 either in CH 2 Cl 2 at room temperature or in toluene at 65 °C and is compatible with the presence ...
Tópico(s): Asymmetric Synthesis and Catalysis
2007 - Wiley | European Journal of Organic Chemistry