Giles Smith, Gráinne Gilmore, Andrew Robson, Henning Mankell, Janice Turner, Amanda Andrews, David Almond, Peter Brookes, Christina Hardyment, Ska Golfer, Nick Foster, Andrew Billen, Robert Cole, Matthew Syed, Beverley Knight, Andrew Pierce, Neil Johnston, Lloyd Williams Consultant orthopaedic surgeon, Donald S. Scott, Sarah Potter, Ben Naparstek, Tom Dyckhoff, Jane MacQuitty, Simon Barnes, Anthony Osmond-Evans, Jasper Rees, Peter Lansley, David Chator, CArol Midgley, Christopher Somerville, Paul Hoggart, Claire McDonald, Christopher Doyle, Mark Frary, Camilla Curtis Physiotherapist, David Rhys Jones, Clare Lazaro, Kathy Lette, Tony Turnbull, Michael Evans Defence Editor, Emma Cook, Philip Howard, Julia Brookes, Carol Midgley, Serena MacKesy, Christine Seib, David Chater, Kate Wighton, Lewis Grassic Gibbon, James Bone, James Ducker, Melissa Katsoulis, Jodie Foster, Rachel Campbell-Johnston, Clive Davis, Damien Whitworth, Richard Hobson One-Day Cricket Correspondent, Kate Reardon, Elizabeth Judge, Richard Irving, Stephanie Debere, Graham Stewart, Joan Rivers, Amanda Andrews Media Business Correspondent, Kenneth A. Webster, Wendy Ide, Anderida Hatch, David Healer, Richard Hollis Chiropractor, Roger Fox Chairman, Cathie Blackwell, Giles Coren, Rosie Millard, Michelle Cazzullno, Vivienne Parry, Gerard Hall Consultant rheumatologist, Dr Copperfield, Alice Pashley, Valerie Elliott Countryside Editor, Leigh Holmwood, Ann Widdecombe, Stephen McClarence, Valerie Elliott, Vinny Lee, Michael Evans and Daniel McGrory, Toby Donovan, Dara O'Briain, Jim Kelsey, Anthony Browne, Tom Bawden, Dominic Walsh, Dan Sabbagh Media Editor, Kathy Hayward, Jack Malvern, Debra Craine, Mike Pattenden, Alan Webster, Allan Simmons, Joe Morgan, Patricia Cumper, Dr Jane Collins, Tim Reid, Daniel Finkelstein, Ruth Gledhill Religion Correspondent, Dalya Alberge Arts Correspondent, Jane Clarke, Nancy Durrent, Jo Morris, Robin Young, Nicholas Roe, Elaine Feinstein, Nick Wyke, Rhys Blakely, James Cotton, specialist, Richard Lloyd Parry, Tina Gaudoin, Fiona McCann, Charles Bremner, Ron Lewis, Adam Sherwin Media Correspondent, Stefanie Marsh, Liz Chong, Lucy Sweeney, Stephen Spurdon, Jean Marshall, Tim Teeman, Hugo Rifkind, Emlyn Whitley, Jake Arnott, Rebecca Worrell, Russell Kempson, Maria Harding, Andrew Purcell, David Rowan, Daniel McGrory, Marsaden, Carola Long, Ed Potton, Stephen Anderton, Stevie Chick, Sarah Vine, Mark Atherton, Lisa Armstrong, Rick Broadbent, Alan Jordan Chiropractor, Morgan Falconer, Antonia Senior Personal Finance Editor, Richards Ford, Sally Baker, Pete Paphides, Neel Mukherjee, David Baddiel, John Hopkins Golf Correspondent, Rob Wright, Geoffrey Dean, Jane Fearnley-Whittingstall, Christina Koning, Magnus Grimond, Neil Harman Tennis Correspondent, David Powell Athletics Correspondent, Martin Samuel, John Williams, Mary Donald, Raymond Keene, Jeremy Marshall, Ray Main, Adam Sage, Suzi Godson, Nicola Bailey, Lewis Smith, Hilary Freeman, Louise Cardani, Rebecca O'Connor, Steve Corbett Consultant orthopaedic surgeon, Gordon Ramsay, Kim Righetti, Sean O'Neill, Rosemary Bennett Deputy Political Editor, Elizabeth Judge Telecome Correspondent, Fay Weldon Novelist, Jeremy Page, Peta Bee, Gary Jacob and George Caulkin, Chris Campling, The Rev K. Ian Hobbs, Pip Clothier, Patrick Hosking, Helen Nugent, Richard Owen, Joyce Vetterlein Osteopath, Hilly Janes, Julie Myerson, Ross Leckie, Morrissey, Erica Wagner, Marcel Berlins, Mark Heap, David Mattin, Ross Boatman, Nick Hasell, Andrew Jack, Seamus Heaney, Peter Hamlyn Consultant neorosurgeon, Dalya Alberge, Sarah Burton, Tom Dart, Frank Egerton, Julian Muscat, Paul Simons, Ruth Scurr, Nicholas Clee, Steve Jelbert, Nigel Kendall, William Rees-Mogg, Clare Allan, Giles Whittell, Trish Fromby Physiotherapist, Robert Crampton, Claire McDonald Body&Soul Spa Editor, Michael Grosvenor Myer, Craig Lord, Ian Johns, Dominic Maxwell, Alice Fordham, Mark Souster and David Hands Rugby Correspondent, Matthew Parris, Amanda Craig, David Bennington, George Caulkin, Imran Khan, Tim Wapshott, Russell Jenkins, Howard Swains, Caitlin Moran, Rebecca Ley, The Rev John C. Greatbatch, Iain Finlayson, Neil Fisher, Jamie Theakston, Ben MacIntyre, Helen Pridham, Graham Wynne Chief Executive, Richard Beeston Diplomatic Editor, Barbara Catchpole, Alison Gibson, Suzanna Cobb, Jacqui Goddard, Graham Searjeant, John Naish, Annabelle Thorpe, Martin Waller, Mark Henderson, Professor Geoffrey Alderman, Christopher Gillibrand, James Jackson, Nigel Hawkes Health Editor, Sarah Butler, Anna Shepard, Benedict Nightingale, Sam Coates Political Correspondent, Dr Thomas Stuttaford, Jill Crawshaw, Tom Bryant, Nicola Woolcock, Leo Lewis, Stephen Dalton, Alyson Rudd, Richard Morrison, James Christopher, Alice Miles, Philip Pullman, John Hoyland, Indarjit Singh, Cath Urquhart Travel Editor, Olav Bjortomt, Jenny Davey, Joe Aveline Former chairman, Richard Ford, James Catford Chief executive, Peter Klinger, Nick Meo, Ian McEwan, Amanda Joy Colley,
... The Times District and Circle Planting the Alder Rizzoli One poet in search of a title Seamus ... Bestsellers Bookseller's Chart Flapjacks, travel and romance: Nicola Bailey reveals the books mums in Hertfordshire really ...
2006 - Gale Group | TDA
Luize Otero, Arthur Moellmann, Maria S. Pombo‐de‐Oliveira, Maria Helena Ornellas, Virgínia Pires, Luís Fernando Bouzas, Teresa de Souza Fernandez,
... Isabel De Celis, Francesca Morandi, Cecilia Caramatti, Vittorio Rizzoli, Nicola Giuliani, European Journal of Haematology
Tópico(s): Chronic Lymphocytic Leukemia Research
2007 - Wiley | European Journal Of Haematology
Stephen Dodgson, Kenneth McLeish, Barbara Hall, Paul Channon, Mike Graham, Jim Tucker, Peter Willmot, John Davison, Rob Hughes, Andrew Grice Political Correspondent, Bemard Cafferty, Sheila Ferguson, Marion Holland, Terrence Stamp, John Diamond, Neville Hodgkinson Medical Correspondent, Graham Rose, Roy Porter, Norman Howell, Nicolette Jones, Diana Wright Personal Finance Editor, Arnold Kellett, Michael Meyer, Rupert Christiansen, Olive Townsley Clerk, David Smith, Marten Julian, Mike Brearley, Dalbert Hallenstein, Cal McCrystal, Mark Hosenball, L Taylor, Edward Welsh, Dr Ian Dunlop, Pamela Pilbeam, C Crofton-Sleigh, Geordie Greig, Patrick Stoddart, Mario Modiano, Robert Sandall, Alex Sutherland, Iain Johnstone, Susan Marling, Norma Hornby, I W Roberts, Paul Quarry, Irwin Stelzer, E Jane Dickson, Robert Hewison, Ivan Fallon, David Dougill, Cliff Temple, Valerie Elliott, Judy Merwezen, Tina Wolfson, Briony Hallam, Hugh Canning, Margarette Driscoll, Dan Barrett, Susan Crosland, David Cairns, Norman Harris, Michael Hartland, Alan Brownjohn, David Connett, Julia Neuberger, John Dodd, Anne Moffat, Robert Harris, Austin MacCurtain Editor, Peter Millar, Timothy O'Grady, George Perry, John Cassidy, Sue Mott, Robin Marlar, Rose Shepherd, Peter Warren, Christine Toomey, Marie Laura Avignolo, Nicola Shulman, Stuart Wavell, Beverly Pagram, Paul Donovan, Janette Marshall, Bernard Richards, Amit Roy, Angela Newing, Greg Dyke, Jeff Randall, Andrew Davison Chair, Jonathan Sale, James Adams, Paul Driver, Richard Binns, Ray Wyre, David Hughes, David Leppard, Tim Rayment, Dilip Hiro, Joan Forman, Elizabeth Grice, Nick Gilbert, John Hopkins, Celia Brayfield, Brian Walden, Peter Wilsher, Gareth David, Brian Reading, Kate Saunders, Kate Carr, Norman Myers, Malcolm Winton, Michael Brooks, Diana Wright, Craig Brown, Andrew Lorenz Industrial Editor, Sue Fallon, Stephen Jones, Brian Deer, Norman Lebrecht, Richard Palmer, Andrew Grice, Keith Wheatley, Miranda Seymour, Dilys Powell, Bryan Appleyard, Emanuel Litvinoff, Andrew Sanger, Andrew Hogg, Brough Scott, Greg Headfield Education Correspondent, Caroline McGhie, Jo Wade, Richard Woods, Louise Branson, A Lockyer Director General, Marion Hume, Max Prangnell, Maurice Chittenden, Barrie Penrose, Iola Smith, Felix Aprahamian, John Tracy, David Hughes Chief Political Correspondent, Ray Mgadzah, J A May, Brian MacArthur, Douglas Hogg Parliamentary Under Secretary, Michael Jones Political Editor, Brian Ketchell, Hannah Ward, Susan Raven, Mihir Bose, Godfrey Smith, Lord Hartwell, Richard Burnell, Olivia Sagan, Frank Davis, Brian Glanville, Rt Hon Sir Barney Hayhoe MP, John Carey, Norman Macrae, Edward Pearce, Steven Berkoff, Simon Jenkins, Godfrey Golzen, Deirdre Fernand, Nick Fielding, James Smith, Peter, Maryon Tysoe, Gareth David Deputy City Editor, Imre Karacs, Andrew Lorenz, John Furbisher, Peter Burley, Valerie Grove, Hugh Pearman, Marina Vaizey, Jeff Randall City Editor, Richard Caseby, Margaret Park, Rosemary Collins, Angela Long, Aghios Nikolaos, Martin Seymour-Smith, Dorothy Wade, David Smith Economics Editor, Michael Thompson Hon Sec, James Saunders, Tony Hetherington, Penny Perrick, C J Fox, Brenda Jones, Dr Conrad Gorinsky Chairman, James Neilson, Joanna Simon, Chris Blackhurst, James Adams Defence Correspondent, Boris Schapiro, Brendan McMahon,
... Views of the Adirondacks: photographs by Nelson Farb (Rizzoli International, £45) Trek the yeti trail One adventure ...
1989 - Gale Group | Sunday Times HA GDA
Roberto Feuda, Matthew Goulty, Nicola Zadra, Tiziana Gasparetti, Ezio Rosato, Davide Pisani, Annapaola Rizzoli, Nicola Segata, Lino Ometto, Omar Rota‐Stabelli,
Abstract Diptera is one of the biggest insect orders and displays a large diversity of visual adaptations. Similarly to other animals, the dipteran visual process is mediated by opsin genes. Although the diversity and function of these genes are well studied in key model species, a comprehensive comparative genomic study across the dipteran phylogeny is missing. Here we mined the genomes of 61 dipteran species, reconstructed the evolutionary affinities of 528 opsin genes, and determined the selective ...
Tópico(s): Animal Behavior and Reproduction
2021 - Oxford University Press | Genome Biology and Evolution
Andrew Robson, Lucy Alexander, Amanda Andrews, Kathryn Hughes, Fred Redwood, David Brown, Greg Hurst Political Correspondent, John Brennand, Frances Gibb Legal Editor, Gary Duncan, Amanda Ursell, Peter Lansley, Robert Lindsay, David Rose, Ian Winrow, Philip Howard, David Lister Scotland Correspondent, Christine Seib, David Chater, Jeremy Kingston, James Ducker, Rachel Campbell-Johnston, Sarbjit Ganger, Lorna Blackwood, Elizabeth Judge, Will Pavia, Sam Marlowe, Dr Ellie Lee Senior lecturer in social policy, James Hider, John Bungey, Geoff Brown, Lucy Bannerman, Robin Pagnamenta, Jabbar Hasan, Ben Webster Transport Correspondent, Nancy Durrant, Kasia Maciejowska, Maurice Wren, Rob Crilly, Pedro Lunguela, Gabby Logan, Roger McCANN, Dominic Walsh, Gary Jacob, Hannah Mitchell, Tim Reid, John D. Hart, Phoebe Greenwood, Richard Ford Home Correspondent, Anne Ashworth Property Editor, Lord Walton, Alan Hamilton, David Sharrock Ireland Correspondent, Alan Millard, Elizabeth Colman, Jessie Hewitson, Alison White Chief Executive, Andy Middleton, Tim Lott, Adam Sherwin Media Correspondent, Norman Miller, Stefanie Marsh, Tim Teeman, Susan Thompson, Hugo Rifkind, Derwent May, Russell Kempson, Paula Hawkins, Jeremy Lee, Suzy Jagger, Gary Duncan Economics Editor, Gerard Baker, Mark Henderson Science Editor, John Westerby, James Harding Business Editor, Tom Baldwin, James Rossiter, Sam Coates, Pete Paphides, Ann Treneman, Simon de Bruxelles, Rob Wright, Alice Olins, Gabriel Rozenberg, Neil Harman Tennis Correspondent, Marcus Binney, Raymond Keene, Adam Sage, Lewis Smith, Tim Reilly, Matt Hughes, Christine Buckley Industrial Editor, Paul Lester, Kaveh Solhekol, Chris Campling, Richard Owen, Lindsey Bareham, Mick Hume, Roger Boyes, Francesca Steele, Dalya Alberge, Kevin Maher, Tom Dart, Tony Cascarino, Julian Muscat, Paul Simons, Thomas Fletcher, Roderick Thompson, Steve Jelbert, Michelle Henery, Nick Szczepanik, Anne Ashworth, Philip Webster Political Editor, Sam Coates Chief Political Correspondent, Steve Hawkes, Jane Shilling, Thomas Catán, Russell Jenkins, Peter Riddell, Philip Webster, Sir George Pinker, David Sanderson, Kate Eshelby, Martin Waller, Mark Loveday, Lewis Smith Environment Reporter, Chris Ayres, Alan Johnston, Sarah Butler, Ashling O'Connor, Stuart Birch, Stephen Dalton, Nicola Woolcock, Tony Halpin, Adam Sherwin, Michael Evans, Judith Heywood, Alan Lee Racing Correspondent, Rosemary Behan, Olav Bjortomt, Alan Dronsfield, David Robertson, Christopher Irvine, Jayne Dowle,
... Marketing 'fanfare' disturbs head of archive Medieval enigma Rizzoli It may look like the Apocalypse but in ...
2007 - Gale Group | TDA
Simona Colla, Francesca Morandi, Mirca Lazzaretti, Rita Rizzato, Paolo Lunghi, Sabrina Bonomini, Cecilia Mancini, Mario Pedrazzoni, Monica Crugnola, Vittorio Rizzoli, Nicola Giuliani,
Osteopontin (OPN) is a multifunctional bone matrix glycoprotein that is involved in angiogenesis, cell survival and tumor progression. In this study we show that human myeloma cells directly produce OPN and express its major regulating gene Runx2/Cbfa1. The activity of Runx2/Cbfa1 protein in human myeloma cells has also been demonstrated. Moreover, using small interfering RNA (siRNA) to silent Runx2 in myeloma cells, we suppressed OPN mRNA and protein expression. OPN production in myeloma cells was ...
Tópico(s): Cell Adhesion Molecules Research
2005 - Springer Nature | Leukemia
Marina Bolzoni, Paola Storti, Sabrina Bonomini, Katia Todoerti, Daniela Guasco, Denise Toscani, Luca Agnelli, Antonino Neri, Vittorio Rizzoli, Nicola Giuliani,
Multiple myeloma (MM)–induced osteoclast (OC) formation is mainly due to an imbalance of the receptor activator NF-κB ligand (RANKL)–osteoprotegerin (OPG) ratio in favor of RANKL in the bone microenvironment and to the CCL3 production by MM cells. The purpose of the study was to investigate the effect of the immunomodulatory drugs on RANKL/OPG ratio, the production of pro-osteoclastogenic cytokines, and MM-induced OC formation. We found that in vivo concentrations of both lenalidomide (LEN) and pomalidomide ( ...
Tópico(s): Protein Degradation and Inhibitors
2012 - Elsevier BV | Experimental Hematology
Paola Storti, Gaetano Donofrío, Simona Colla, Irma Airoldi, Marina Bolzoni, Luca Agnelli, Manuela Abeltino, Katia Todoerti, Mirca Lazzaretti, Cecilia Mancini, Doménico Ribatti, Sabrina Bonomini, Valentina Franceschi, Vito Pistoia, Gina Lisignoli, Alessio Pedrazzini, Ottavio Cavicchi, Antonino Neri, Vittorio Rizzoli, Nicola Giuliani,
The deregulation of the homeobox genes as homeoboxB (HOXB)-7 has been previously associated to tumor progression and angiogenesis; here we investigated the potential role of HOXB7 in the pro-angiogenic properties of multiple myeloma (MM) cells. We found that HOXB7 was expressed in 10 out of 22 MM patients analyzed at the diagnosis related to high bone marrow angiogenesis and overexpressed in about 40% of myeloma cell lines compared with normal plasma cells. Enforced HOXB7 expression in MM cells by ...
Tópico(s): Multiple Myeloma Research and Treatments
2010 - Springer Nature | Leukemia
Simona Colla, Sara Tagliaferri, Francesca Morandi, Paolo Lunghi, Gaetano Donofrío, Davide Martorana, Cristina Mancini, Mirca Lazzaretti, Laura Mazzera, Lara Ravanetti, Sabrina Bonomini, Luca Ferrari, Claudia Miranda, Marco Ladetto, Tauro Maria Neri, Antonino Neri, Angela Greco, Marcellina Mangoni, Antonio Bonati, Vittorio Rizzoli, Nicola Giuliani,
Angiogenesis has a critical role in the pathophysiology of multiple myeloma (MM); however, the molecular mechanisms underlying this process are not completely elucidated. The new tumor-suppressor gene inhibitor of growth family member 4 (ING4) has been recently implicated in solid tumors as a repressor of angiogenesis. In this study, we found that ING4 expression in MM cells was correlated with the expression of the proangiogenic molecules interleukin-8 (IL-8) and osteopontin (OPN). Moreover, we demonstrate ...
Tópico(s): Glycosylation and Glycoproteins Research
2007 - Elsevier BV | Blood
Produção Nacional
Revisado por pares
Simona Colla, Francesca Morandi, Mirca Lazzaretti, P. Polistena, Mirija Svaldi, P Coser, Sabrina Bonomini, Magda Hojden, Eugenia Martella, Teodoro Chisesi, Vittorio Rizzoli, Nicola Giuliani,
Basic fibroblast growth factor (bFGF) is a growth factor with proangiogenetic properties. Elevated bone marrow (BM) and peripheral serum bFGF levels have been reported in patients with multiple myeloma (MM)[1][1]-[3][2]; however, the source of bFGF in patients with MM is not completely elucidated.
Tópico(s): Proteoglycans and glycosaminoglycans research
2003 - Elsevier BV | Blood
Nicholas R. Fuggle, Charlotte Beaudart, Olivier Bruyère, Bo Abrahamsen, Nasser M. Al‐Daghri, Nansa Burlet, Manju Chandran, Màrio Miguel Rosa, Bernard Cortet, Céline Demonceau, W. Dere, Philippe Halbout, Mickaël Hiligsmann, John А. Kanis, Jean‐Marc Kaufman, Andreas Kurth, Olivier Lamy, Andrea Laslop, Stefania Maggi, Radmila Matijević, Eugène McCloskey, Ali Mobasheri, María Concepción Prieto Yerro, Régis Radermecker, Shaun Sabico, Yousef Al‐Saleh, Stuart Silverman, Nicola Veronese, René Rizzoli, Cyrus Cooper, Jean‐Yves Reginster, Nicholas C. Harvey,
Historically, osteoporosis has been viewed as a disease of women, with research, trials of interventions and guidelines predominantly focused as such. It is apparent, however, that this condition causes a substantial health burden in men also, and that its assessment and management must ultimately be addressed across both sexes. In this article, an international multidisciplinary working group of the European Society for Clinical and Economic Aspects of Osteoporosis, Osteoarthritis and Musculoskeletal ...
Tópico(s): Bone Metabolism and Diseases
2024 - Nature Portfolio | Nature Reviews Rheumatology
Mickaël Hiligsmann, Daniel Pinto, Elaine Dennison, Nasser M. Al‐Daghri, Charlotte Beaudart, Jaime Branco, Olivier Bruyère, Philip G. Conaghan, Cyrus Cooper, Gabriel Herrero‐Beaumont, Famida Jiwa, Willem F. Lems, René Rizzoli, Thierry Thomas, Nicola Veronese, Jean‐Yves Reginster,
Tópico(s): Nasal Surgery and Airway Studies
2019 - Springer Science+Business Media | Aging Clinical and Experimental Research
Sangyong Jung, Tanja Maritzen, Carolin Wichmann, Zhizi Jing, Andreas Neef, Natalia H. Revelo, Hanan Al‐Moyed, Sandra Meese, Sonja M. Wojcik, Iliana Panou, Haydar Bulut, Peter Schu, Ralf Ficner, Ellen Reisinger, Silvio O. Rizzoli, Jakob Neef, Nicola Strenzke, Volker Haucke, Tobias Moser,
Article7 October 2015free access Disruption of adaptor protein 2μ (AP-2μ) in cochlear hair cells impairs vesicle reloading of synaptic release sites and hearing SangYong Jung SangYong Jung Institute for Auditory Neuroscience and InnerEarLab, University Medical Center Göttingen, Göttingen, Germany Collaborative Research Center 889, University of Göttingen, Göttingen, Germany Synaptic Nanophysiology Group, Max Planck Institute for Biophysical Chemistry, Göttingen, Germany Search for more papers by ...
Tópico(s): Cellular transport and secretion
2015 - Springer Nature | The EMBO Journal
Produção Nacional
Revisado por pares
Simona Colla, Paola Storti, Gaetano Donofrío, Katia Todoerti, Marina Bolzoni, Mirca Lazzaretti, Manuela Abeltino, Luigi Ippolito, Antonino Neri, Doménico Ribatti, Vittorio Rizzoli, E Martella, Nicola Giuliani,
Tópico(s): Angiogenesis and VEGF in Cancer
2010 - Springer Nature | Leukemia
Gina Lisignoli, Katia Codeluppi, Katia Todoerti, Cristina Manferdini, A. Piacentini, Nicoletta Zini, Francesco Grassi, Luca Cattini, Roberta Piva, Vittorio Rizzoli, Andrea Facchini, Nicola Giuliani, Antonino Neri,
Abstract Bone marrow stromal cells (MSCs) and osteoblasts are the two main non‐haematopoietic cellular components of human bone tissue. To identify novel osteoblast‐related molecules, we performed a gene expression profiling analysis comparing MSCs and osteoblasts isolated from the same donors. Genes differentially overexpressed in osteoblasts were mainly related to the negative control of cell proliferation, pro‐apoptotic processes, protein metabolism and bone remodelling. Notably, we also identified ...
Tópico(s): Bone health and treatments
2009 - Wiley | Journal of Cellular Physiology
Katia Todoerti, Gina Lisignoli, Paola Storti, Luca Agnelli, Francesca Novara, Cristina Manferdini, Katia Codeluppi, Simona Colla, Monica Crugnola, Manuela Abeltino, Marina Bolzoni, Valentina Sgobba, Andrea Facchini, Giorgio Lambertenghi‐Deliliers, Orsetta Zuffardi, Vittorio Rizzoli, Antonino Neri, Nicola Giuliani,
Objective Multiple myeloma (MM) is characterized by a high incidence of osteolytic bone lesions, which have been previously correlated with the gene expression profiles of MM cells. The aim of this study was to investigate the transcriptional patterns of cells in the bone microenvironment and their relationships with the presence of osteolysis in MM patients. Materials and Methods Both mesenchymal (MSC) and osteoblastic (OB) cells were isolated directly from bone biopsies of MM patients and controls to perform ...
Tópico(s): Bone health and treatments
2009 - Elsevier BV | Experimental Hematology
Lori A. Ehrlich, Ho Yeon Chung, Irene M. Ghobrial, Sun Jin Choi, Francesca Morandi, Simona Colla, Vittorio Rizzoli, G. David Roodman, Nicola Giuliani,
Abstract Bone destruction in multiple myeloma is characterized both by markedly increased osteoclastic bone destruction and severely impaired osteoblast activity. We reported that interleukin-3 (IL-3) levels are increased in bone marrow plasma of myeloma patients compared with healthy controls and that IL-3 stimulates osteoclast formation. However, the effects of IL-3 on osteoblasts are unknown. Therefore, to determine if IL-3 inhibits osteoblast growth and differentiation, we treated primary mouse ...
Tópico(s): Bone Metabolism and Diseases
2005 - Elsevier BV | Blood
Pietro Castellan, Michele Marchioni, Ambra Rizzoli, Marta Di Nicola, Italo Porfilio, Jamil Ghahhari, Francesco Greco, Luigi Schips, Luca Cindolo,
To assess the extent to which surgical experience can affect perioperative and functional outcomes after photoselective vaporization of the prostate (PVP) with 180W XPX GreenLight laser in patients with lower urinary tract symptoms secondary to benign prostatic obstruction (BPO).Data from 291 consecutive patients with symptomatic BPO (median follow-up 12 m) were collected and analyzed. Patients were treated at 2 different institutions by 2 expert (G1, n = 182) and 2 novice (G2, n = 109) transurethral prostate ...
Tópico(s): Pelvic floor disorders treatments
2018 - Mary Ann Liebert, Inc. | Journal of Endourology
Manuela Abeltino, Sabrina Bonomini, Marina Bolzoni, Paola Storti, Simona Colla, Katia Todoerti, Luca Agnelli, Antonino Neri, Vittorio Rizzoli, Nicola Giuliani,
Objective Multiple myeloma (MM) cells are extremely resistant to drug-induced apoptosis due to both intrinsic- and bone marrow (BM) microenvironment–dependent drug resistance particularly supported by bone cells. Growing evidence suggest that the osteoclast inhibitor zoledronic acid (ZOL) exerts both indirect and direct anti-tumoral effects, including an in vitro proapoptotic effect on MM cells, although this property has not yet been clearly observed in MM patients. Materials and Methods In this study, we ...
Tópico(s): Cytokine Signaling Pathways and Interactions
2010 - Elsevier BV | Experimental Hematology
Andrea Giustina, John P. Bilezikian, Robert A. Adler, Giuseppe Banfi, Daniel D. Bikle, Neil Binkley, Jens Bollerslev, Roger Bouillon, Maria Luisa Brandi, Felipe F. Casanueva, Luigi di Filippo, Lorenzo M. Donini, Peter R. Ebeling, Ghada El‐Hajj Fuleihan, Angelo Fassio, Stefano Frara, Glenville Jones, Claudio Marcocci, Adrian R. Martineau, Salvatore Minisola, Nicola Napoli, Massimo Procopio, René Rizzoli, Anne L. Schafer, Christopher T. Sempos, Fabio Massimo Ulivieri, Jyrki K. Virtanen,
Abstract The 6th International Conference, “Controversies in Vitamin D,” was convened to discuss controversial topics, such as vitamin D metabolism, assessment, actions, and supplementation. Novel insights into vitamin D mechanisms of action suggest links with conditions that do not depend only on reduced solar exposure or diet intake and that can be detected with distinctive noncanonical vitamin D metabolites. Optimal 25-hydroxyvitamin D (25(OH)D) levels remain debated. Varying recommendations from ...
Tópico(s): Bone health and osteoporosis research
2024 - Oxford University Press | Endocrine Reviews
Nicholas R. Fuggle, Jean‐Yves Reginster, Nasser M. Al‐Daghri, Olivier Bruyère, Nansa Burlet, Claudia Campusano, Cyrus Cooper, Adolfo Díez‐Pérez, Philippe Halbout, Tullio Ghi, Jean‐Marc Kaufman, Andreas Kurt, Radmila Matijević, Régis Radermecker, Şansın Tüzün, Nicola Veronese, René Rizzoli, Nicholas C. Harvey, Maria Luisa Brandi, Maria Luisa Brandi,
Radiofrequency Echographic Multi Spectrometry (REMS) is a radiation-free, portable technology, which can be used for the assessment and monitoring of osteoporosis at the lumbar spine and femoral neck and may facilitate wider access to axial BMD measurement compared with standard dual-energy x-ray absorptiometry (DXA).There is a growing literature demonstrating a strong correlation between DXA and REMS measures of BMD and further work supporting 5-year prediction of fracture using the REMS Fragility ...
Tópico(s): Body Composition Measurement Techniques
2024 - Springer Science+Business Media | Aging Clinical and Experimental Research
Nicola Giuliani, Vittorio Rizzoli,
Bone destruction is the hallmark of multiple myeloma (MM) due to the high capacity of malignant plasma cells to induce a severe imbalance of bone remodeling. Growing evidences suggest that MM cell interactions with bone marrow (BM) osteoblast have a critical role in the pathophysiology of osteolytic lesions. Indeed histomorphometric studies have demonstrated that MM patients with osteolytic bone lesions have lower numbers of osteoblasts and decreased bone formation together with osteoclast activation. ...
Tópico(s): Peptidase Inhibition and Analysis
2007 - Taylor & Francis | Leukemia & lymphoma/Leukemia and lymphoma
Nicola Giuliani, Vittorio Rizzoli, G. David Roodman,
Abstract Multiple myeloma (MM) is a plasma cell malignancy characterized by a high capacity to induce osteolytic bone lesions. Bone destruction in MM results from increased osteoclast formation and activity that occur in close proximity to myeloma cells. However, histomorphometric studies have demonstrated that MM patients with osteolytic bone lesions have lower numbers of osteoblasts and decreased bone formation. This impaired bone formation plays a critical role in the bone-destructive process. ...
Tópico(s): Peptidase Inhibition and Analysis
2006 - Elsevier BV | Blood
Nicola Zadra, Annapaola Rizzoli, Omar Rota‐Stabelli,
One-third of all mosquitoes belong to the Aedini, a tribe comprising common vectors of viral zoonoses such as Aedes aegypti and Aedes albopictus. To improve our understanding of their evolution, we present an updated multigene estimate of Aedini phylogeny and divergence, focusing on the disentanglement between nuclear and mitochondrial phylogenetic signals. We first show that there are some phylogenetic discrepancies between nuclear and mitochondrial markers which may be caused by wrong taxa assignment ...
Tópico(s): Insect symbiosis and bacterial influences
2021 - Multidisciplinary Digital Publishing Institute | Life
Produção Nacional
Revisado por pares
John P. Bilezikian, Anna Maria Formenti, Robert A. Adler, Neil Binkley, Roger Bouillon, Marise Lazaretti‐Castro, Claudio Marcocci, Nicola Napoli, René Rizzoli, Andrea Giustina,
The 4
Tópico(s): Eating Disorders and Behaviors
2021 - Springer Science+Business Media | Reviews in Endocrine and Metabolic Disorders
Produção Nacional
Revisado por pares
Andrea Giustina, Roger Bouillon, Neil Binkley, Christopher T. Sempos, Robert A. Adler, Jens Bollerslev, Bess Dawson‐Hughes, Peter R. Ebeling, David Feldman, Annemieke C. Heijboer, Glenville Jones, Christopher S. Kovacs, Marise Lazaretti‐Castro, Paul Lips, Claudio Marcocci, Salvatore Minisola, Nicola Napoli, René Rizzoli, Robert Scragg, John H. White, Anna Maria Formenti, John P. Bilezikian,
Abstract The Third International Conference on Controversies in Vitamin D was held in Gubbio, Italy, September 10–13, 2019. The conference was held as a follow‐up to previous meetings held in 2017 and 2018 to address topics of controversy in vitamin D research. The specific topics were selected by the steering committee of the conference and based upon areas that remain controversial from the preceding conferences. Other topics were selected anew that reflect specific topics that have surfaced since ...
Tópico(s): Bone health and osteoporosis research
2020 - Wiley | JBMR Plus
Alessandra Costanzo, Aldo Romani, Diego Masotti, Nicola Arbizzani, Vittorio Rizzoli,
The paper addresses a new integrated design of RF/Microwave receivers and conversion systems for energy harvesting to be adopted in ultra-low power density environments. Such systems can be very useful in typical humanized scenarios in the presence of existing wireless systems with power densities as low as a few μW/cm2. Despite of the scarce RF power available, energy usable to extend battery life or to self-power low-duty cycle electronics may be scavenged by highly efficient receivers and power ...
Tópico(s): Wireless Power Transfer Systems
2012 - Elsevier BV | Sensors and Actuators A Physical
Maria Pia Villa, Maria Chiara Paolino, Rosa Castaldo, Nicola Vanacore, Alessandra Rizzoli, Silvia Miano, Marco Pozzo, Marilisa Montesano,
Overnight polysomnography (PSG) is an expensive procedure which can only be used in a minority of cases, although it remains the gold standard for the diagnosis of sleep disordered breathing (SDB). The objective of this study was to develop a simple, PSG-validated tool to screen SDB, thus reducing the use of PSG. For every participant we performed PSG and a sleep clinical record was completed. The sleep clinical record consists of three items: physical examination, subjective symptoms and clinical ...
Tópico(s): Respiratory Support and Mechanisms
2012 - European Respiratory Society | European Respiratory Journal
Marina Bolzoni, Manuela Abeltino, Paola Storti, Sabrina Bonomini, Luca Agnelli, Katia Todoerti, Antonino Neri, Vittorio Rizzoli, Nicola Giuliani,
Abstract Abstract 448 The increase of osteoclast formation and activation occurring into the bone marrow (BM) area of myeloma cells infiltration is the hallmark of multiple myeloma (MM). The increase of the RANKL/OPG ratio in BM stromal cells (BMSCs) and osteoprogenitor cells, induced by MM cells through the cell-to-cell contact, is critically involved in MM-induced osteoclast formation. In addition, MM cells also up-regulate RANKL expression and secretion by activated T in the MM BM microenvironment. ...
Tópico(s): Protein Degradation and Inhibitors
2010 - Elsevier BV | Blood
Paola Rizzoli, Luca Dell’Amore, José–Luis Bueso–Bello, Nicola Gollin, Daniel Carcereri, Michele Martone,
The bistatic interferometric coherence is affected by different sources of error, among which volume decorrelation, which quantifies the amount of noise caused by volume scattering mechanisms. This represents a key quantity not only for the performance assessment of interferometric synthetic aperture radar (SAR) products, but also for a large variety of scientific applications, ranging from land cover classification to physical parameters estimation, such as ice structure, forest height, and biomass ...
Tópico(s): Soil Moisture and Remote Sensing
2022 - Institute of Electrical and Electronics Engineers | IEEE Journal of Selected Topics in Applied Earth Observations and Remote Sensing