Nicolai Grønne Jørgensen, Shamaila Munir Ahmad, Niels Abildgaard, Per thor Straten, Inge Marie Svane, Mads Hald Andersen, Lene Meldgaard Knudsen,
The B-cell lymphoma-2 (Bcl-2) family of proteins play a crucial role in multiple myeloma (MM), contributing to lacking apoptosis which is a hallmark of the disease. This makes the Bcl-2 proteins interesting targets for therapeutic peptide vaccination. We report a phase I trial of therapeutic vaccination with peptides from the proteins Bcl-2, Bcl-X
Tópico(s): Monoclonal and Polyclonal Antibodies Research
2016 - AME Publishing Company | Stem Cell Investigation
Evelina Martinenaite, Rasmus Erik Johansson Mortensen, Morten Hansen, Morten Orebo Holmström, Shamaila Munir Ahmad, Nicolai Grønne Jørgensen, Özcan Met, Marco Donia, Inge Marie Svane, Mads Hald Andersen,
The enzyme arginase-1 reduces the availability of arginine to tumor-infiltrating immune cells, thus reducing T-cell functionality in the tumor milieu. Arginase-1 is expressed by some cancer cells and by immune inhibitory cells, such as myeloid-derived suppressor cells (MDSCs) and tumor-associated macrophages (TAMs), and its expression is associated with poor prognosis. In the present study, we divided the arginase-1 protein sequence into overlapping 20-amino-acid-long peptides, generating a library ...
Tópico(s): Adenosine and Purinergic Signaling
2017 - Landes Bioscience | OncoImmunology
Uffe Klausen, Staffan Holmberg, Morten Orebo Holmström, Nicolai Grønne Jørgensen, Jacob Handlos Grauslund, Inge Marie Svane, Mads Hald Andersen,
Peptides vaccination is an interesting tool to direct T-cells towards desired antigens in hematological malignancies. In addition to classical tumor associated antigens, such as cancer testis antigens, new potential targets for peptide vaccination comprise neo-antigens including JAK2 and CALR mutations, and antigens from immune regulatory proteins in the tumor microenvironment such as programmed death 1 ligands (PD-L1 and PD-L2). Immunosuppressive defenses of tumors are an important challenge to ...
Tópico(s): Acute Myeloid Leukemia Research
2018 - Frontiers Media | Frontiers in Immunology
Uffe Klausen, Nicolai Grønne Jørgensen, Jacob Handlos Grauslund, Morten Orebo Holmström, Mads Hald Andersen,
Tópico(s): Immune Cell Function and Interaction
2018 - Springer Science+Business Media | Seminars in Immunopathology
Nicolai Grønne Jørgensen, Uffe Klausen, Jacob Handlos Grauslund, Carsten Helleberg, Thomas Granum Aagaard, Trung Hieu, Shamaila Munir Ahmad, Lars Rønn Olsen, Tobias Wirenfeldt Klausen, Marie Fredslund Breinholt, Morten Hansen, Evelina Martinenaite, Özcan Met, Inge Marie Svane, Lene Meldgaard Knudsen, Mads Hald Andersen,
Immune checkpoint blockade with monoclonal antibodies targeting programmed death 1 (PD-1) and its ligand PD-L1 has played a major role in the rise of cancer immune therapy. We have identified naturally occurring self-reactive T cells specific to PD-L1 in both healthy donors and cancer patients. Stimulation with a PD-L1 peptide (IO103), activates these cells to exhibit inflammatory and anti-regulatory functions that include cytotoxicity against PD-L1-expressing target cells. This prompted the initiation ...
Tópico(s): vaccines and immunoinformatics approaches
2020 - Frontiers Media | Frontiers in Immunology
Jacob Handlos Grauslund, Morten Orebo Holmström, Nicolai Grønne Jørgensen, Uffe Klausen, Stine Emilie Weis-Banke, Daniel El Fassi, Claudia Schöllkopf, Mette Borg Clausen, Lise Mette Rahbek Gjerdrum, Marie Fredslund Breinholt, Julie Westerlin Kjeldsen, Morten Hansen, Steffen Koschmieder, Nicolas Chatain, Guy Wayne Novotny, Jesper Petersen, Lasse Kjær, Vibe Skov, Özcan Met, Inge Marie Svane, Hans Carl Hasselbalch, Mads Hald Andersen,
The calreticulin (CALR) exon 9 mutations that are identified in 20% of patients with Philadelphia chromosome negative chronic myeloproliferative neoplasms (MPN) generate immunogenic antigens. Thus, therapeutic cancer vaccination against mutant CALR could be a new treatment modality in CALR-mutant MPN.The safety and efficacy of vaccination with the peptide CALRLong36 derived from the CALR exon 9 mutations was tested in a phase I clinical vaccination trial with montanide as adjuvant. Ten patients with ...
Tópico(s): Eosinophilic Disorders and Syndromes
2021 - Frontiers Media | Frontiers in Oncology
Simone K. Bendtsen, Maria Perez-Penco, Mie Linder Hübbe, Evelina Martinenaite, Morten Orebo Holmström, Stine Emilie Weis-Banke, Nicolai Grønne Jørgensen, Mia Aaboe Jørgensen, Shamaila Munir Ahmad, Kasper Mølgaard, Christina Friese, Mia Thorup Lundsager, Astrid Z. Johansen, Marco Carretta, Niels Ødum, Özcan Met, Inge Marie Svane, Daniel H. Madsen, Mads Hald Andersen,
Galectin-3 (Gal3) can be expressed by many cells in the tumor microenvironment (TME), including cancer cells, cancer-associated fibroblasts, tumor-associated macrophages, and regulatory T cells (Tregs). In addition to immunosuppression, Gal3 expression has been connected to malignant cell transformation, tumor progression, and metastasis. In the present study, we found spontaneous T-cell responses against Gal3-derived peptides in PBMCs from both healthy donors and cancer patients. We isolated and expanded ...
Tópico(s): Macrophage Migration Inhibitory Factor
2022 - Landes Bioscience | OncoImmunology
Nicolai Grønne Jørgensen, Jeanette Kaae, Jacob Handlos Grauslund, Özcan Met, Signe Ledou Nielsen, Ayako Wakatsuki Pedersen, Inge Marie Svane, E. Ehrnrooth, Mads Hald Andersen, Claus Zachariae, Lone Skov,
Antitumor activity of immune checkpoint blocking antibodies against programmed death 1 (PD-1) in basal cell carcinoma (BCC) has been described. IO103 is a peptide vaccine against the major PD-1 ligand PD-L1. A phase IIa study of vaccination with IO103 and Montanide adjuvant was conducted in patients with resectable BCC (NCT03714529). Vaccinations were given six times every 2 weeks (q2w), followed by three vaccines q4w in responders. Primary endpoints were clinical responses of target tumors, change ...
Tópico(s): Immunotherapy and Immune Responses
2021 - Multidisciplinary Digital Publishing Institute | Cancers
Nicolai Jørgensen, Eric Leif Meline, Stefan Starup Jeppesen, Olfred Hansen, Morten Nielsen, Tine Schytte,
Background: The treatment of choice for patients with locally advanced non-small cell lung cancer (LA-NSCLC) in good performance status is definitive radiotherapy (RT), the five-year survival being approximately 25–30%. Advances in the diagnostic procedures and treatment modalities in NSCLC have increased the overall survival, making identifying factors with impact on survival increasingly relevant. Recent research indicates that tumor laterality has impact on the survival of patients with LA-NSCLC ...
Tópico(s): Effects of Radiation Exposure
2019 - Taylor & Francis | Acta Oncologica
Jacob Handlos Grauslund, Morten Orebo Holmström, Evelina Martinenaite, Thomas Landkildehus Lisle, Hannah Jorinde Glöckner, Daniel El Fassi, Uffe Klausen, Rasmus Erik Johansson Mortensen, Nicolai Grønne Jørgensen, Lasse Kjær, Vibe Skov, Inge Marie Svane, Hans Carl Hasselbalch, Mads Hald Andersen,
Introduction Arginase-1 (ARG1) and Programed death ligand-1 (PD-L1) play a vital role in immunosuppression in myeloproliferative neoplasms (MPNs) and directly inhibit T-cell activation and proliferation. We previously identified spontaneous T-cell responses towards PD-L1 and ARG1 derived peptide epitopes in patients with MPNs. In the present First-in-Man study we tested dual vaccinations of ARG1- derived and PD-L1-derived peptides, combined with Montanide ISA-51 as adjuvant, in patients with Janus ...
Tópico(s): Chronic Myeloid Leukemia Treatments
2023 - Frontiers Media | Frontiers in Immunology
Nicolai Lohse, Louise B. Jørgensen, Gitte Kronborg, Axel Møller, Birgit Kvinesdal, Henrik Toft Sørensen, Niels Obel, Jan Gerstoft, J Gerstat, Niels Obel, Gitte Kronborg, C Pedersen, Carsten Schade Larsen, Gert Frølund Pedersen, Alex Lund Laursen, Birgit Kvinesdal, Axel Møller,
To examine the prevalence of drug-resistance-associated mutations in HIV patients with triple-drug class virological failure (TCF) and their association with long-term mortality.Population-based study from the Danish HIV Cohort Study (DHCS).We included all patients in the DHCS who experienced TCF between January 1995 and November 2004, and we performed genotypic resistance tests for International AIDS Society (IAS)-USA primary mutations on virus from plasma samples taken around the date of TCF. We ...
Tópico(s): Pneumocystis jirovecii pneumonia detection and treatment
2007 - SAGE Publishing | Antiviral Therapy
Thomas J. D. Jørgensen, Nicolai Bache, Peter Roepstorff, Henrik Gårdsvoll, Michael Ploug,
Considerable controversy exists in the literature as to the occurrence of intramolecular migration of amide hydrogens upon collisional activation of protonated peptides and proteins. This phenomenon has important implications for the application of CID as an experimental tool to obtain site-specific information about the incorporation of deuterium into peptides and proteins in solution. Using a unique set of peptides with their carboxyl-terminal half labeled with deuterium we have shown unambiguously ...
Tópico(s): Analytical Chemistry and Chromatography
2005 - Elsevier BV | Molecular & Cellular Proteomics
Sowmya R. Ramachandran, Nicolai Krogh, Tor Erik Jørgensen, Steinar Johansen, Henrik Nielsen, Igor Babiak,
During zebrafish development, an early type of rRNA is gradually replaced by a late type that is substantially different in sequence. We applied RiboMeth-seq to rRNA from developmental stages for profiling of 2′- O -Me, to learn if changes in methylation pattern were a component of the shift. We compiled a catalog of 2′- O -Me sites and cognate box C/D guide RNAs comprising 98 high-confidence sites, including 10 sites that were not known from other vertebrates, one of which was specific to late-type ...
Tópico(s): RNA Research and Splicing
2020 - Cold Spring Harbor Laboratory Press | RNA
Frederik Plesner Lyngse, Kåre Mølbak, Robert Skov, Lasse Engbo Christiansen, Laust Hvas Mortensen, Mads Albertsen, Camilla Holten Møller, Tyra Grove Krause, Morten Rasmussen, Thomas Yssing Michaelsen, Marianne Voldstedlund, Jannik Fonager, Nina R. Steenhard, Jakob Brandt, Simon Knuttson, Emil A. Sørensen, Thomas Bygh Nymann Jensen, Trine Sørensen, Celine Petersen, Clarisse Chiche-Lapierre, Frederik T. Hansen, Emilio F. Collados, Amalie Berg, Susanne R. Bielidt, Sebastian Mølvang Dall, Erika Dvarionaite, Susan Hove Hansen, Vibeke Børsholt Rudkjøbing, Trine B. Nicolajsen, Wagma Saei, Stine Karstenskov Østergaard, Thomas Yssing Michaelsen, Vang Quy Le, Mantas Sereika, Rasmus Hansen Kirkegaard, Kasper Skytte Andersen, Martin Hjorth Andersen, Karsten Kryger Hansen, Mads Boye, Mads P. Bach, Peter Dissing, Anton Drastrup-Fjordbak, Michael Collin, Finn Büttner, Susanne Andersen, L. Otte, Martin Bøgsted, Rasmus Froberg Brøndum, Katja Hose, Tomer Sagi, Miroslav Pakanec, Anders Fomsgaard, Søren Michael Karst, Vithiagaran Gunlan, Marc Bennedbæk, Raphael N. Sieber, Kirsten Ellegaard, Anna Cäcilia Ingham, Thor Bech Johannesen, Martín Basterrechea, Berit Lilje, Kim Lee Ng, Sofie Marie Edslev, Sharmin Baig, Marc Stegger, Povilas Matusevicius, Lars Christoffersen, Man-Hung Eric Tang, Christina Wiid Svarrer, Nour Saad Al-Tamimi, Marie Bækvad‐Hansen, Jonas Byberg-Grauholm, Mette T. Christiansen, Karen Mare Jørgensen, Nicolai Balle Larsen, Arieh S. Cohen, Henrik Krarup, David Fuglsang-Damgaard, Mette Mølvadgaard, Marc T. K. Nielsen, Kristian Schønning, Martin Schou Pedersen, Rasmus L. Marvig, Nikolai Kirkby, Uffe Vest Schneider, José Alfredo Samaniego Castruita, Nana G. Jacobsen, Christian Østergaard Andersen, Mette T. Christiansen, Ole H. Larsen, Kristian Alsbjerg Skipper, Søren Vang, Kurt Handberg, Carl M. Kobel, Camilla Andersen, Irene Harder Tarpgaard, Svend Ellermann‐Eriksen, Marianne Nielsine Skov, Thomas Vognbjerg Sydenham, Lene Nielsen, Line Nilsson, Martin Barfred Friis, Thomas Sundelin, Thomas Arn Hansen, Anders Møller Jensen, Ea S. Marmolin, Xiaohui Chen Nielsen, Christian Højte Schouw, John Coia, Dorte Terp Andersen, Carsten Kirkeby,
New lineages of SARS-CoV-2 are of potential concern due to higher transmissibility, risk of severe outcomes, and/or escape from neutralizing antibodies. Lineage B.1.1.7 (the Alpha variant) became dominant in early 2021, but the association between transmissibility and risk factors, such as age of primary case and viral load remains poorly understood. Here, we used comprehensive administrative data from Denmark, comprising the full population (January 11 to February 7, 2021), to estimate household ...
Tópico(s): COVID-19 epidemiological studies
2021 - Nature Portfolio | Nature Communications
Matthew D. Lycas, Aske L. Ejdrup, Andreas T. Sørensen, Nicolai O. Haahr, Søren Jørgensen, Daryl A. Guthrie, Jonatan Fullerton Støier, Christian Werner, Amy Hauck Newman, Markus Sauer, Freja Herborg, Ulrik Gether,
The nanoscopic organization and regulation of individual molecular components in presynaptic varicosities of neurons releasing modulatory volume neurotransmitters like dopamine (DA) remain largely elusive. Here we show, by application of several super-resolution microscopy techniques to cultured neurons and mouse striatal slices, that the DA transporter (DAT), a key protein in varicosities of dopaminergic neurons, exists in the membrane in dynamic equilibrium between an inward-facing nanodomain-localized ...
Tópico(s): Lipid Membrane Structure and Behavior
2022 - Cell Press | Cell Reports
Stine Bjerrum Møeller, Krzysztof Gbyl, Carsten Hjorthøj, Maike Andreasen, Stephen F. Austin, Poul Erik Buchholtz, Line Fønss, Simon Hjerrild, Lise Hogervorst, Martin Balslev Jørgensen, Nicolai Ladegaard, Klaus Martiny, Jonas Meile, Aake Packness, Karen Rodriguez Sigaard, Krista Nielsen Straarup, Sune Puggaard Vogt Straszek, Claus Havregaard Soerensen, Birgitte Welcher, Poul Videbech,
Background Difficult-to-treat-depression (DTD) is a clinical challenge. The interventions that are well-established for DTD are not suitable or effective for all the patients. Therefore, more treatment options are highly warranted. We formulated an evidence-based guideline concerning six interventions not well-established for DTD in Denmark.Methods Selected review questions were formulated according to the PICO principle with specific definitions of the patient population (P), the intervention (I), ...
Tópico(s): Anxiety, Depression, Psychometrics, Treatment, Cognitive Processes
2021 - Taylor & Francis | Nordic Journal of Psychiatry
Morsi W. Abdallah, Erik Lykke Mortensen, Kirstin Greaves‐Lord, Nicolai Balle Larsen, Eva Cecilie Bonefeld‐Jørgensen, B Nørgaard‐Pedersen, David M. Hougaard, Jakob Grove,
Objective To examine levels of 3 neurotrophic factors (NTFs): Brain derived neurotrophic factor ( BDNF ), Neurotrophin‐4 ( NT ‐4), and transforming growth factor‐β ( TGF ‐β) in dried blood spot samples of neonates diagnosed with autism spectrum disorders ( ASD ) later in life and frequency‐matched controls. Method Biologic samples were retrieved from the D anish N ewborn S creening B iobank. NTF s for 414 ASD cases and 820 controls were measured using L uminex technology. Associations were analyzed with continuous ...
Tópico(s): Genetics and Neurodevelopmental Disorders
2012 - Wiley | Acta Psychiatrica Scandinavica
David C. Poole, Timothy I. Musch,
... exercise: role of cGMP signalingPeter Piil, Tue Smith Jørgensen, Jon Egelund, Nicolai Rytter, Lasse Gliemann, Jens Bangsbo, Ylva Hellsten, and ...
Tópico(s): Sports Performance and Training
2009 - American Physiological Society | Journal of Applied Physiology
Uffe Klausen, Nicolai Grønne Jørgensen, Jacob Handlos Grauslund, Shamaila Munir Ahmad, Anne Ortved Gang, Evelina Martinenaite, Stine Emilie Weis-Banke, Marie Fredslund Breinholt, Guy Wayne Novotny, Julie Westerlin Kjeldsen, Morten Orebo Holmström, Lone Bredo Pedersen, Christian Bjørn Poulsen, Per Boye Hansen, Özcan Met, Inge Marie Svane, Carsten Utoft Niemann, Lars Møller Pedersen, Mads Hald Andersen,
Cells in the tumor microenvironment of Follicular lymphoma (FL) express checkpoint molecules such as programmed death ligands 1 and 2 (PD-L1 and PD-L2) and are suppressing anti-tumor immune activity. Stimulation of peripheral blood mononuclear cells (PBMC) with PD-L1 (IO103) or PD-L2 (IO120) peptides can activate specific T cells inducing anti-regulatory functions including cytotoxicity against PD-L1/PD-L2-expressing cells. In this study, we vaccinated eight FL patients with PD-L1 and PD-L2 peptides ...
Tópico(s): Immunotherapy and Immune Responses
2021 - Landes Bioscience | OncoImmunology
Nicolai Bo Vanting, Zheng Ma, Bo Nørregaard Jôrgensen,
Abstract The increasing dependency on electricity and demand for renewable energy sources means that distributed system operators face new challenges in their grid. Accurate forecasts of electric load can solve these challenges. In recent years deep neural networks have become increasingly popular in research, and researchers have carried out many experiments to create the most accurate deep learning models. Players in the energy sector can exploit the increasing amount of energy-related data collected ...
Tópico(s): Solar Radiation and Photovoltaics
2021 - Springer Nature | Energy Informatics
Lene Russell, Sarah Weihe, Emilie Kabel Madsen, Christine Lodberg Hvas, Jens Wolfgang Leistner, Jens Michelsen, Anne Craveiro Brøchner, Anders Bastiansen, Frederik Mølgaard Nielsen, Nick Meier, Anne Sofie Andreasen, Niels‐Erik Ribergaard, Bodil Steen Rasmussen, Christoffer Sølling, David Levarett Buck, Henning Bundgaard, Helle Scharling Pedersen, Iben S. Darfelt, Lone Musaeus Poulsen, Michael Ibsen, Ronni R. Plovsing, Sigurdur T. Sigurdsson, Susanne Iversen, Thomas Hildebrandt, Thomas Mohr, Ulrick Espelund, Vibeke R. L. Jørgensen, Nicolai Haase, Anders Perner,
Intensive care unit (ICU) patients with Coronavirus disease 2019 (COVID-19) have an increased risk of thromboembolic complications. We describe the occurrence of thromboembolic and bleeding events in all ICU patients with COVID-19 in Denmark during the first and second waves of the pandemic.This was a sub-study of the Danish Intensive Care Covid database, in which all patients with SARS-CoV-2 admitted to Danish ICUs from 10th March 2020 to 30th June 2021 were included. We registered coagulation variables ...
Tópico(s): COVID-19 and healthcare impacts
2022 - Wiley | Acta Anaesthesiologica Scandinavica
Kasper D. Rand, Nicolai Bache, Morten M. Nedertoft, Thomas J. D. Jørgensen,
Mass spectrometry has become a powerful tool for measuring protein hydrogen exchange and thereby reveal the structural dynamics of proteins in solution. Here we describe the successful application of a matrix-assisted laser desorption ionization (MALDI) mass spectrometry approach based on in-source decay (ISD) to measure spatially resolved amide backbone hydrogen exchange. By irradiating deuterated protein molecules in a crystalline matrix with a high laser fluence, they undergo prompt fragmentation. ...
Tópico(s): Ion-surface interactions and analysis
2011 - American Chemical Society | Analytical Chemistry
Sara R. Bang-Christensen, Rasmus S. Pedersen, Marina Ayres Pereira, Thomas Mandel Clausen, Caroline Løppke, Nicolai T. Sand, Theresa D. Ahrens, Amalie M. Jørgensen, Yi Chieh Lim, Louise Goksøyr, Swati Choudhary, Tobias Gustavsson, Robert Dagil, Mads Daugaard, Adam F. Sander, Mathias H. Torp, Max Søgaard, Thor G. Theander, Oľga Østrup, Ulrik Lassen, Petra Hamerlik, Ali Salanti, Mette Ø. Agerbæk,
Diffuse gliomas are the most common primary malignant brain tumor. Although extracranial metastases are rarely observed, recent studies have shown the presence of circulating tumor cells (CTCs) in the blood of glioma patients, confirming that a subset of tumor cells are capable of entering the circulation. The isolation and characterization of CTCs could provide a non-invasive method for repeated analysis of the mutational and phenotypic state of the tumor during the course of disease. However, the ...
Tópico(s): Cancer Cells and Metastasis
2019 - Multidisciplinary Digital Publishing Institute | Cells
Nicolai Grønne Jørgensen, Jeanette Kaae, Jacob Handlos Grauslund, Özcan Met, Inge Marie Svane, E. Ehrnrooth, Mads Hald Andersen, Claus Zachariae, Lone Skov,
e22070 Background: Basal cell carcinoma (BCC) is the most frequent malignancy. Case reports have described effect of immune checkpoint blocking antibodies (ICB) against PD-1 in BCC (Cannon et al. 2018, Chang et al. 2017, Ikeda et al. 2016, Winkler et al. 2017). Autoimmune side effects of ICB are well known and limits a wider use in BCC. IO103 is a peptide vaccine against major programmed death (PD) ligand 1 (PD-L1). In a first-in-man study of IO103 in patients with multiple myeloma (NCT03042793) regression ...
Tópico(s): Tumors and Oncological Cases
2020 - Lippincott Williams & Wilkins | Journal of Clinical Oncology
Uffe Klausen, Jacob Handlos Grauslund, Nicolai Grønne Jørgensen, Shamaila Munir Ahmad, Merete Jonassen, Stine Emilie Weis-Banke, Evelina Martinenaite, Lone Bredo Pedersen, Thomas Landkildehus Lisle, Anne Ortved Gang, Lisbeth Enggaard, Morten Hansen, Morten Orebo Holmström, Özcan Met, Inge Marie Svane, Carsten Utoft Niemann, Lars Møller Pedersen, Mads Hald Andersen,
Chronic lymphocytic leukemia (CLL) patients with unmutated immunoglobulin heavy chain (IgHV) are at risk of early disease progression compared to patients with mutated IgHV. As a preventive strategy, we treated 19 previously untreated CLL patients with unmutated IgHV in a phase 1/2 trial (clinicaltrials.gov, NCT03939234) exploring the efficacy and toxicity of a therapeutic cancer vaccine containing peptides derived from programmed death ligand 1 (PD-L1) and ligand 2 (PD-L2), hoping to restore immunological ...
Tópico(s): Immune Cell Function and Interaction
2022 - Frontiers Media | Frontiers in Oncology
Frederik Nicolai Foldager, Peter Bo Jørgensen, Lisa Urup Tønning, Emil Toft Petersen, Stig Storgaard Jakobsen, Dovydas Vainorius, Morten Homilius, Torben Bæk Hansen, Maiken Stilling, Inger Mechlenburg,
Patients with unilateral hip osteoarthritis appear to have between-leg differences in leg extension power (LEP). The Nottingham Leg Extensor Power Rig provides reliable and valid results but requires sensitive equipment. It would be relevant to identify measures closely associated with this test.(i) To investigate if LEP is lower in the affected leg compared to the non-affected leg. Furthermore, to investigate the associations between LEP and the measures: (ii) Functional performance, (iii) accelerometer- ...
Tópico(s): Osteoarthritis Treatment and Mechanisms
2022 - Elsevier BV | Musculoskeletal Science and Practice
Nicolai Lohse, Niels Obel, Gitte Kronborg, Louise B. Jørgensen, Court Pedersen, Carsten Schade Larsen, Birgit Kvinesdal, Henrik Toft Sørensen, Jan Gerstoft,
Transmission of drug-resistant HIV is a potential threat to the substantial clinical benefit of highly active antiretroviral therapy (HAART). To explore the background for the low rates of drug resistance transmission (2.5%) in our population, we estimated acquisition of HIV drug resistance and examined temporal trends in the prevalence of patients at risk of transmitting drug-resistant HIV.The study population included all 4,025 patients from The Danish HIV Cohort Study seen during the period 1995- ...
Tópico(s): HIV/AIDS drug development and treatment
2006 - SAGE Publishing | Antiviral Therapy
John Bagterp Jørgensen, Gianluca Frison, Nicolai Fog Gade-Nielsen, Bernd Damman,
In this paper we present the extended linear quadratic control problem, its efficient solution, and a discussion of how it arises in the numerical solution of nonlinear model predictive control problems. The extended linear quadratic control problem is the optimal control problem corresponding to the Karush-Kuhn-Tucker system that constitute the majority of computational work in constrained nonlinear and linear model predictive control problems solved by efficient MPC-tailored interior-point and ...
Tópico(s): Fault Detection and Control Systems
2012 - Elsevier BV | IFAC Proceedings Volumes
Anne Margrethe Audelin, Nicolai Lohse, Niels Obel, Jan Gerstoft, Louise B. Jørgensen,
Background Newer antiretroviral treatment regimens for HIV carry a lower risk of inducing drug resistance mutations. We estimated changes in incidence rates (IRs) of new mutations in HIV-infected individuals receiving highly active antiretroviral therapy (HAART). Methods Population-based data were obtained from the Danish HIV Cohort Study and the Danish HIV Sequence Database. We included treatment-naive patients initiating HAART after December 1997 and computed time to first drug resistance mutation, ...
Tópico(s): HIV/AIDS Research and Interventions
2008 - SAGE Publishing | Antiviral Therapy
... of α,β-unsaturated aldehydes catalyzed by the Jørgensen–Hayashi catalyst; Nicolai Cramer (ETH Zurich, Laboratory of Organic Chemistry, Zurich, ...
Tópico(s): Various Chemistry Research Topics
2010 - Wiley | Chemistry - A European Journal