Produção Nacional
Revisado por pares
Ana Paula Mendes‐Silva, Kelly Silva Pereira, Gesiane Thamire Tolentino-Araújo, Eduardo de Souza Nicolau, Camila Moreira Silva-Ferreira, Antônio Lúcio Teixeira, Breno S. Diniz,
Objective The clinical–epidemiological relationship between major depressive disorder (MDD) and Alzheimer disease (AD) suggests that they may share common neurobiologic abnormalities. Methods The authors conducted a systematic review and identified microRNAs abnormally expressed in both AD and MDD. The pattern of microRNA regulation in each disorder and the genes regulated by each microRNA and the biologic processes and pathways regulated by these genes were identified. Results Seventy-four microRNAs ...
Tópico(s): Neuroinflammation and Neurodegeneration Mechanisms
2016 - Elsevier BV | American Journal of Geriatric Psychiatry
Produção Nacional
Revisado por pares
Ana Paula Mendes‐Silva, Patrícia Tiemi Fujimura, Jéssica Regina da Costa Silva, Antônio Lúcio Teixeira, Érica Leandro Marciano Vieira, Pedro Guedes, Lucélia Scarabeli Silva Barroso, Mariana de Souza Nicolau, Jéssica Diniz Rodrigues Ferreira, Laiss Bertola, Eduardo de Souza Nicolau, Gesiane Thamire Tolentino-Araújo, Camila Moreira Silva Ferreira Berlezzi, Tamíris Sabrina Rodrigues, Luiza Diniz Ferreira Borges, Matheus de Souza Gomes, Laurence Rodrigues do Amaral, Ana Maria Bonetti, Carlos Ueira-Vieira, Breno S. Diniz,
Changes in microRNAs (miRNAs) expression have been described in major depressive disorder in young and middle-aged adults. However, no study has evaluated miRNA expression in older adults with major depression (or late-life depression [LLD]). Our primary aim was to evaluate the expression of miRNAs in subjects with LLD. We first evaluated the miRNA expression using next-generation sequencing (NGS) and then we validated the miRNAs found in NGS in an independent sample of LLD patients, using RT-qPCR. ...
Tópico(s): Extracellular vesicles in disease
2019 - Elsevier BV | Journal of Psychiatric Research
Produção Nacional
Revisado por pares
Ana Paula Mendes‐Silva, Breno S. Diniz, Gesiane Thamire Tolentino Araújo, Eduardo de Souza Nicolau, Kelly Silva Pereira, Camila Moreira Silva Ferreira, Lucélia Silva Barroso,
Previous studies have demonstrated the relevance of cerebrovascular changes, abnormalities in amyloid-β protein metabolism and changes in inflammatory, neurotrophic and endocrine-metabolic markers in depression in the elderly. Similar patterns of abnormalities in these neurobiological cascades were also found in patients with Alzheimer's Disease (AD) and in patients with amnestic Mild Cognitive Impairment (MCI) who progressed to AD during longitudinal follow-up. These results suggest that depression ...
Tópico(s): MicroRNA in disease regulation
2017 - Wiley | Alzheimer s & Dementia
Rodrigo Gomes de Oliveira Pinto,
Na obra satírica do poeta lusitano Nicolau Tolentino de Almeida (1740-1811), os sonetos “Aos toucados altos” e “O colchão dentro do toucado” podem ser lidos como exemplares de poesia cômico- ... comedimento. Manuel Pinheiro Chagas (1842-1895), leitor oitocentista de Nicolau Tolentino, afirma que o uso do verbo “photographar” não é capaz de dizer a vividez descritiva dos versos desses sonetos, ...
Tópico(s): Linguistics and Language Studies
2018 - | Revista Desassossego
... receita e despesa, conferindo particular atenção à confraria de S. Nicolau Tolentino e Almas da igreja do convento do Pópulo da cidade de Braga na ligação de um dos seus membros ...
Tópico(s): Religious Tourism and Spaces
2021 - Centre de Recherches sur les Mondes Américains | Nuevo mundo mundos nuevos
Tópico(s): Historical Studies in Latin America
2004 - Fundacao Calouste Gulbenkian | Colóquio. Letras
Produção Nacional
Revisado por pares
... de ascensao social pelo emprego publico de Francisco Nicolau Tolentino, um funcionario de origens humildes que chegou a presidir a provincia ...
Tópico(s): Social and Economic Solidarity
2003 - UNIVERSIDADE FEDERAL DO RIO GRANDE DO SUL | Sociologias
Correia Garção, Domingos dos Reis Quita, José Basílio da Gama, Antônio Dinis da Cruz e Silva, Cláudio Manuel da Costa, Inácio José de Alvarenga Peixoto, Manuel Inácio da Silva Alvarenga, Teresa de Melo Breyner, Nicolau Tolentino de Almeida, Catarina de Lencastre, Manuel Maria Barbosa du Bocage, Alberto Magalhães, Simões Dias, Guerra Junqueiro, Machado de Assis, José Branquinho,
Antologia de poemas (1759-1905).
Tópico(s): Literature, Culture, and Criticism
2021 - | Teresa
Produção Nacional
... Império, no qual o autor identificado é Antônio Nicolau Tolentino, que solicita o desligamento de uma linha telefônica entre as duas instituições. O ...
Tópico(s): Literature, Culture, and Criticism
2021 - | LaborHistórico
Produção Nacional
Revisado por pares
Ana Paula Mendes M Silva, Eduardo de Souza S. Nicolau, Kelly Silva Pereira, Kenia Kelly Fiaux do Nascimento, Camila Moreira Silva MS Ferreira, Gesiane Thamire Tolentino TT Araujo, Breno S. Diniz, Antônio Lúcio Teixeira,
Major Depressive Disorder (MDD) and Alzheimer's disease (AD) present a clinical-epidemiological relationship suggesting that neurobiological abnormalities may be found in common in both conditions. Presenting complexity and probably bidirectional relationship, despite well-defined differences in clinical manifestations. In young and older adults, even after successful antidepressant treatment, Cognitive Impairment due to depressive episodes is common and persistent. Furthermore, higher rates of depressive ...
Tópico(s): MicroRNA in disease regulation
2016 - Wiley | Alzheimer s & Dementia
Produção Nacional
Revisado por pares
Roberto Carlos de Oliveira, Rodrigo Venâncio da Silva, Elisa Chain de Assis, Gabriel Coimbra Carvalho Schuwarten, Dilceu Silveira Tolentino Júnior, Ana Valéria Machado Mendonça, Belinda Nicolau, Andréa Maria Duarte Vargas, Efigênia Ferreira e Ferreira,
This study shows how it was possible to engage in intersubjective dialogue regarding the replacement of models and uses of Maxakali traditional drinks with a distilled beverage introduced through inter-ethnic contact. A comprehensive phenomenological approach was employed to understand and describe the social perceptions about the use of this distillate. Through thematic analysis, symbols and meanings of alcohol use were interpreted through their daily life histories, recorded by 21 leaders in three ...
Tópico(s): Youth, Drugs, and Violence
2022 - Grupo de Pesquisa Metodologias em Ensino e Aprendizagem em Ciências | Research Society and Development
Produção Nacional
Revisado por pares
The life of Antonio Nicolau Tolentino makes possible to reconstitute 19th century Brazil’s social and political dynamics, and also the wider context of relations between ...
Tópico(s): History of Colonial Brazil
2009 - UNIVERSIDADE DE SÃO PAULO | Literatura e Sociedade
Produção Nacional
Revisado por pares
... guidance. More than a biography, the trajectory of Nicolau Tolentino may be seen as a kind of pretext ...
Tópico(s): Brazilian History and Foreign Policy
2009 - UNIVERSIDADE DE SÃO PAULO | Literatura e Sociedade