Nils Eriksen, Lester D. Ellerbrook, Edward C. Meek, Stuart W. Lippincott,
... V. The Heat “Coagulation” of Plasma Get access Nils Eriksen, Nils Eriksen Search for other works by this author on: ...
Tópico(s): Biomarkers in Disease Mechanisms
1951 - Oxford University Press | JNCI Journal of the National Cancer Institute
Edmund L. Keeney, Nils Eriksen,
Tópico(s): Transgenic Plants and Applications
1949 - Elsevier BV | Journal of Allergy
Ian R. Mackay, Wade Volwiler, Patrick D. Goldsworthy, Nils Eriksen, Patricia A. Wood,
Tópico(s): Erythrocyte Function and Pathophysiology
1954 - American Society for Clinical Investigation | Journal of Clinical Investigation
Ian R. Mackay, Nils Eriksen, Arno G. Motulsky, Wade Volwiler,
Five patients with varying degrees of cryo- and macroglobulinemia have been studied and the physicochemical characteristics of these abnormal proteins investigated. 1.1. Macroglobulins are giant protein molecules with a molecular weight of over one million. Cryoglobulins are proteins which precipitate on cooling but redissolve on warming to body temperature. Occasionally, an abnormal plasma protein may be both a cryo- and macroglobulin. These abnormal proteins are probably elaborated by the reticuloendothelial- ...
Tópico(s): Erythrocyte Function and Pathophysiology
1956 - Elsevier BV | The American Journal of Medicine
George M. Martin, Earl P. Benditt, Nils Eriksen,
5-Hydroxytryptamine (5-HT) consumes oxygen in the presence of pooled serum from pregnant humans and ceruloplasmin concentrates. The properties of the catalyst in serum were those of an enzyme. 5-HT oxidase may be identical with the enzyme which oxidizes p-phenylenediamine. Chromatography of incubation mixtures containing 5-HT and serum or 5-HT and ceruloplasmin concentrates revealed several indolic products as well as a pigment having properties similar to the melanins. These products appear to be ...
Tópico(s): Electrochemical Analysis and Applications
1960 - Elsevier BV | Archives of Biochemistry and Biophysics
Nils Eriksen, George M. Martin, Earl P. Benditt,
The products of the metabolism of 5-hydroxytryptamine are of interest not only because of their possible physiological importance but also because of their pathological potentialities. Although the oxidation of the ethylamine portion of the molecule has been extensively investigated (1) only suggestions have been made concerning oxidation of the indole nucleus: Dalgliesh (2) has proposed that 5-hydroxytryptamine may be metabolized to a substance of enhanced physiological activity, e.g. 5,6or 4,5-dihydroxytryptamine; ...
Tópico(s): Olfactory and Sensory Function Studies
1960 - Elsevier BV | Journal of Biological Chemistry
George M. Martin, Earl P. Benditt, Nils Eriksen,
Tópico(s): Oxidative Organic Chemistry Reactions
1960 - Nature Portfolio | Nature
David C. Parmelee, Koiti Titani, Lowell H. Ericsson, Nils Eriksen, Earl P. Benditt, Kenneth A. Walsh,
... lipoproteinDavid C. Parmelee, Koiti Titani, Lowell H. Ericsson, Nils Eriksen, Earl P. Benditt, and Kenneth A. WalshCite this: ...
Tópico(s): Peroxisome Proliferator-Activated Receptors
1982 - American Chemical Society | Biochemistry
Mark A. Hermodson, Robert W. Kuhn, Kenneth A. Walsh, Hans Neurath, Nils Eriksen, Earl P. Benditt,
... Robert W. Kuhn, Kenneth A. Walsh, Hans Neurath, Nils Eriksen, and Earl P. BendittCite this: Biochemistry 1972, 11, ...
Tópico(s): Protein Structure and Dynamics
1972 - American Chemical Society | Biochemistry
Nils Eriksen, Lowell H. Ericsson, Nancy N. Pearsall, David Lagunoff, Earl P. Benditt,
The major protein extracted from anyloid deposits induced in mice by injection of either Candida albicans cells or sodium caseinate was found to have chromatographic and electrophoretic properties and an amino-acid compostiion characteristic of the AA class of amyloid proteins. The homology of the mouse protein with protein AA from man and monkey was established by determination of the sequence of the first 28 amino-acid residues.
Tópico(s): Enzyme Structure and Function
1976 - National Academy of Sciences | Proceedings of the National Academy of Sciences
Nils Eriksen, Earl P. Benditt,
Two apoproteins immunologically related to the 9000-dalton abnormal tissue constituent known as amyloid protein AA were isolated from the lipoprotein density interval 1.125-1.21 g/cm3 (HDL3) of a pool of human serums by delipidation, gel filtration, and ion-exchange chromatography. Lesser amounts of the same apoproteins were isolated from the density interval 1.063-1.125 g/cm3 (HDL2). These apoproteins, designated apoSAA1 and apoSAA2, have molecular weights near 11,500, almost identical amino acid ...
Tópico(s): Diabetes, Cardiovascular Risks, and Lipoproteins
1980 - National Academy of Sciences | Proceedings of the National Academy of Sciences
Earl P. Benditt, Nils Eriksen, R H Hanson,
Mouse plasma contains a protein antigenically related to mouse protein AA, the principal protein derived from tissue deposits of amyloid substance in mice. In this work the plasma antigen, SAA, was found mainly as a high molecular weight form (2 x 10(5)) residing for the most part in the density interval 1.063-1.21 g/cm3 (high density lipoprotein, HDL); the largest amount of SAA, absolute and relative to total protein, was found in the density interval 1.125-12.1 g/cm3 (HDL3). When apoproteins of the ...
Tópico(s): Lipid metabolism and biosynthesis
1979 - National Academy of Sciences | Proceedings of the National Academy of Sciences
Earl P. Benditt, Joshua Hoffman, Nils Eriksen, David C. Parmelee, Kenneth A. Walsh,
Annals of the New York Academy of SciencesVolume 389, Issue 1 p. 183-189 SAA, AN APOPROTEIN OF HDL: ITS STRUCTURE AND FUNCTION* E. P. Benditt, E. P. Benditt Department of Pathology University of Washington Seattle, Washington 98195Search for more papers by this authorJ. S. Hoffman, J. S. Hoffman Department of Pathology University of Washington Seattle, Washington 98195Search for more papers by this authorN. Eriksen, N. Eriksen Department of Pathology University of Washington Seattle, Washington ...
Tópico(s): Lipoproteins and Cardiovascular Health
1982 - Wiley | Annals of the New York Academy of Sciences
Nils Eriksen, Earl P. Benditt,
Several apoproteins not readily detectable in normal serum lipoproteins were found in markedly increased amounts in the lipoprotein density interval 1.125–1.21 g/ml (HDL3) of serum obtained from victims of severe trauma. Following electrophoretic separations, they were shown to be isotypes of the acute-phase protein serum amyloid A (SAA) by immunoreaction with antiserum to the structurally related tissue amyloid protein A (AA). The two principal apoSAA isotypes in the HDL3 of trauma patients appear ...
Tópico(s): Amyloidosis: Diagnosis, Treatment, Outcomes
1984 - Elsevier BV | Clinica Chimica Acta
J S Hoffman, Lowell H. Ericsson, Nils Eriksen, Kenneth A. Walsh, Earl P. Benditt,
Amyloid protein AA is the presumptive fragment of an acute phase serum apolipoprotein, apoSAA. Two major murine apoSAA isotypes (apoSAA1 and apoSAA2) have been identified. The NH2-terminal amino acid sequences of purified murine apoSAA1 and apoSAA2 have been examined and compared with that of murine amyloid protein AA. Our results indicate that apoSAA1 and apoSAA2 are separate gene products and that amyloid protein AA has NH2-terminal amino acid sequence identity with only one of these isotypes, ...
Tópico(s): Amyloidosis: Diagnosis, Treatment, Outcomes
1984 - Rockefeller University Press | The Journal of Experimental Medicine
Lowell H. Ericsson, Nils Eriksen, Kenneth A. Walsh, Earl P. Benditt,
The amino acid sequence has been determined for the major protein that accumulates in amyloid fibrils in tissues of the Pekin duck. With the exception of 16 residues at the amino terminus, this 106‐residue protein is homologous with human serum amyloid protein A (104‐residue apoSAA), which is the putative precursor of the 76‐residue protein that accumulates in human patients with amyloidosis. Duck serum is shown to contain a protein that is immunologically related and approximately equal in size ( ...
Tópico(s): Trace Elements in Health
1987 - Wiley | FEBS Letters
Nils Eriksen, Earl P. Benditt,
The discovery of a unique protein (AA) characteristic of amyloid deposits in tissues of patients with chronic inflammatory diseases have led to the immunological recognition of a structurally related protein (SAA) in human serum. This chapter describes the preparation of ApoSAA, physical and chemical characteristics of ApoSAA, and assay of SAA. ApoSAA might participate in a variety of molecular associations, any one of which could interfere to some extent with its detection. Limited proteolysis of ...
Tópico(s): Drug Transport and Resistance Mechanisms
1986 - Academic Press | Methods in enzymology on CD-ROM/Methods in enzymology
Earl P. Benditt, Nils Eriksen,
Communicated by Shields Warren and read before the Academy, October 12, 19651 Amyloid is the name applied to deposits of material in the intercellular spaces of many organs and tissues.Most frequently seen in liver, spleen, and kidney, it may occur in any organ.Three main varieties are recognized: (1) primary, (2) sec- ondary, and (3) associated with multiple myeloma.The secondary variety is the
Tópico(s): Bacteriophages and microbial interactions
1966 - National Academy of Sciences | Proceedings of the National Academy of Sciences
Earl P. Benditt, Nils Eriksen, C. Berglund,
The spectral absorption, optical rotatory dispresion, and circular dichroism associated with interaction of Congo red dye with partly purified suspensions of amyloid fibril fragments were examined. A set of phenomena consistent with a Cotton effect was found. A nearly identical set of phenomena was obtained with poly-L-lysine in its alpha-helical form. The dichroism seen when Congo red binds to amyloid substance in tissue sections can also be interpreted as a Cotton effect. This suggests that some ...
Tópico(s): Protein Structure and Dynamics
1970 - National Academy of Sciences | Proceedings of the National Academy of Sciences
Earl P. Benditt, Nils Eriksen, Mark A. Hermodson, Lowell H. Ericsson,
FEBS LettersVolume 19, Issue 2 p. 169-173 Full-length articleFree Access The major proteins of human and monkey amyloid substance: Common properties including unusual N-terminal amino acid sequences E.P. Benditt, E.P. Benditt Departments of Pathology and Biochemistry of the University of Washington, Seattle, Washington 98195, USASearch for more papers by this authorN. Eriksen, N. Eriksen Departments of Pathology and Biochemistry of the University of Washington, Seattle, Washington 98195, USASearch ...
Tópico(s): Amyloidosis: Diagnosis, Treatment, Outcomes
1971 - Wiley | FEBS Letters
Earl P. Benditt, Nils Eriksen,
Human serums contain a protein antigenically related to protein AA, the principal protein of a major class of amyloid substance. The serum antigen, SAA, occurs mainly in a high molecular weight form, 1 to 2 X 10(5). This work shows that the bulk of the SAA sediments at density 1.12 g/cm3 and floats at density 1.21 g/cm3, as does the high density lipoprotein HDL3. SAA is associated with the apolipoproteins ApoA-I and ApoA-II. The total cholesterol:total protein ratio of the fraction with density ...
Tópico(s): Cholesterol and Lipid Metabolism
1977 - National Academy of Sciences | Proceedings of the National Academy of Sciences
Rick L. Meek, Nils Eriksen, Earl P. Benditt,
The serum amyloid A (SAA) proteins make up a multigene family of apolipoproteins associated with high density lipoproteins. They are of ancient origin; the finding of a highly homologous protein in mammals and ducks indicates that SAAs have been in existence for at least 300 million years. The interspecies similarity among the SAAs makes the mouse, in which they have been most thoroughly studied, a reasonable model to use for defining the function(s) of this family of proteins in humans. Originally ...
Tópico(s): Peroxisome Proliferator-Activated Receptors
1992 - National Academy of Sciences | Proceedings of the National Academy of Sciences
Conrad T. O. Fong, Stuart W. Lippincott, Nils Eriksen,
... this author on: Oxford Academic PubMed Google Scholar Nils Eriksen Nils Eriksen Field Investigations and Demonstrations Branch, National Cancer Institute, ...
Tópico(s): Protein Interaction Studies and Fluorescence Analysis
1957 - Oxford University Press | JNCI Journal of the National Cancer Institute
Nils Eriksen, Lester D. Ellerbrook, Stuart W. Lippincott,
Abstract One hundred serum specimens from healthy and diseased adults were analyzed for the major protein constituents by free electrophoresis and by the Wolfson-Cohn chemical method. Albumin values obtained by the two methods were well correlated and were also in good average numerical agreement. The γ-globulin values were well correlated, but were not in quite such good numerical agreement, on a percentage basis, as were the albumin values. The α-globulin values were poorly correlated, as were ...
Tópico(s): Protein Interaction Studies and Fluorescence Analysis
1956 - American Association for Clinical Chemistry | Clinical Chemistry
Torunn Ervik, Stine Eriksen Hammer, Nils Petter Skaugset, Pål Graff,
Abstract Asbestos containing materials (ACMs) are still found in many buildings even though the use of asbestos in building materials has been prohibited in Norway since 1985. Employees that may be at risk of exposure to airborne fibers are workers within the construction industry. However, firefighters and workers investigating fires may also encounter asbestos fibers in their work. The aim of this study was to investigate the airborne fiber concentration during abatement of various ACMs. A comparison ...
Tópico(s): Occupational and environmental lung diseases
2023 - Oxford University Press | Annals of Work Exposures and Health
Anne Negaard, Else Marit Løberg, Paal Aksel Næss, Morten Eriksen, Nils‐Einar Kløw,
Tópico(s): Eosinophilic Esophagitis
2009 - Springer Science+Business Media | Digestive Diseases and Sciences
Kristoffer Russell, Morten Eriksen, Lars Aaberge, Nils Wilhelmsen, Helge Skulstad, Espen W. Remme, Kristina H. Haugaa, Anders Opdahl, Jan Gunnar Fjeld, Ola Gjesdal, Thor Edvardsen, Otto A. Smiseth,
Left ventricular (LV) pressure–strain loop area reflects regional myocardial work and metabolic demand, but the clinical use of this index is limited by the need for invasive pressure. In this study, we introduce a non-invasive method to measure LV pressure–strain loop area. Left ventricular pressure was estimated by utilizing the profile of an empiric, normalized reference curve which was adjusted according to the duration of LV isovolumic and ejection phases, as defined by timing of aortic and ...
Tópico(s): Cardiovascular Function and Risk Factors
2012 - Oxford University Press | European Heart Journal
Jørn Stave, Gufu Oba, Aud B. Eriksen, Inger Nordal, Nils Chr. Stenseth,
The growth and survival of woody seedlings in arid and semi-arid riverine forests is partly determined by the ability of their roots to maintain contact with the alluvial water table. After a flood event, the water table declines in conjunction with the river stage and the rate of decline may have species-specific effects on the regeneration of riverine trees. In this study, a growth experiment involving seedlings of Acacia tortilis and Faidherbia albida, two keystone tree species along the regulated ...
Tópico(s): Ecology and Vegetation Dynamics Studies
2005 - Elsevier BV | Forest Ecology and Management
Kristoffer Russell, Morten Eriksen, Lars Aaberge, Nils Wilhelmsen, Helge Skulstad, Ola Gjesdal, Thor Edvardsen, Otto A. Smiseth,
Left ventricular (LV) dyssynchrony reduces myocardial efficiency because work performed by one segment is wasted by stretching other segments. In the present study, we introduce a novel noninvasive clinical method that quantifies wasted energy as the ratio between work consumed during segmental lengthening (wasted work) divided by work during segmental shortening. The wasted work ratio (WWR) principle was studied in 6 anesthetized dogs with left bundle branch block (LBBB) and in 28 patients with cardiomyopathy, ...
Tópico(s): Cardiomyopathy and Myosin Studies
2013 - American Physical Society | AJP Heart and Circulatory Physiology
Nils Eriksen, Lester D. Ellerbrook, Stuart W. Lippincott,
Tópico(s): Photodynamic Therapy Research Studies
1951 - Oxford University Press | JNCI Journal of the National Cancer Institute