Davood Javidgonbadi, Bert Andersson, Nils‐Johan Abdon, Maria Schaufelberger, Ingegerd Östman‐Smith,
Objective In order to avoid effects of referral bias, we assessed risk factors for disease-related mortality in a geographical cohort of patients with hypertrophic obstructive cardiomyopathy (HOCM), and any therapy effect on survival. Methods Diagnostic databases in 10 hospitals in the West Götaland Region yielded 251 adult patients with HOCM (128 male, 123 female). Case notes were reviewed for clinical data and ECG and ultrasound findings. Beta-blockers were used in 71.3% of patients from diagnosis ( ...
Tópico(s): Viral Infections and Immunology Research
2019 - BMJ | Open Heart
Per Ola Andersson, Magnus Löndahl, Nils‐Johan Abdon, Andreas Terént,
The aims of this study were to evaluate the community-based prevalence of atrial fibrillation (AF) in a western society using a geographically well-defined population in the northern part of Sweden as a reference and to estimate the proportion of patients eligible for oral anticoagulation (OAC) prophylactic therapy according to the stroke risk indices CHADS2 and CHA2 DS2 -VASc. Bleeding risk was assessed using the HAS-BLED score.The study population was recruited from AURICULA, a Swedish national quality ...
Tópico(s): Venous Thromboembolism Diagnosis and Management
2012 - Wiley | Journal of Internal Medicine
Bert Andersson, Nils‐Johan Abdon, Jan Hammarsten,
In a retrospective study, the frequency of atrial arrhythmias of types known to cause systemic embolisation and the effect of anticoagulant treatment were studied in 106 patients with arterial embolism. Such embolising arrhythimas were found in 84 patients (79%). Permanent atrial fibrillation was documented in 53 patients (50%) and episodic atrial arrhythmia was encountered in 28 patients (26%). In 21 of 28 patients with sinus rhythm on admission, an embolising arrhythmia could be identified in previous ...
Tópico(s): Cardiac Arrhythmias and Treatments
1989 - Elsevier BV | European Journal of Vascular Surgery
Davood Javidgonbadi, Bert Andersson, Nils‐Johan Abdon, Ingegerd Östman‐Smith,
Background Treatment of left ventricular outflow-obstruction (LVOTO) in hypertrophic obstructive cardiomyopathy (HOCM) by short atrio-ventricular delay pacing has long-term hemodynamic results that are not inferior to myectomy, but publications comparing long-term morbidity following those treatments are lacking. Methods A search for HOCM-patients attending all ten hospitals in the West Götaland Region, Sweden, from 2002 through 2013, identified 251 patients (42 treated with myectomy, 88 with pacing ...
Tópico(s): Cardiovascular Function and Risk Factors
2020 - Elsevier BV | International Journal of Cardiology
Sara Kurland, Christopher W. Wheat, Maria de la Paz Celorio‐Mancera, Verena E. Kutschera, Jason Hill, Anastasia Andersson, Carl‐Johan Rubin, Leif Andersson, Nils Ryman, Linda Laikre,
Developing genomic insights is challenging in nonmodel species for which resources are often scarce and prohibitively costly. Here, we explore the potential of a recently established approach using Pool-seq data to generate a de novo genome assembly for mining exons, upon which Pool-seq data are used to estimate population divergence and diversity. We do this for two pairs of sympatric populations of brown trout (Salmo trutta): one naturally sympatric set of populations and another pair of populations ...
Tópico(s): Identification and Quantification in Food
2019 - Wiley | Ecology and Evolution
Davood Javidgonbadi, Nils‐Johan Abdon, Bert Andersson, Maria Schaufelberger, Ingegerd Östman‐Smith,
Examination of long-term results following different treatments in hypertrophic obstructive cardiomyopathy (HOCM) in a complete geographical cohort.HOCM patients attending during 2002-13 in all 10 hospitals in the West Götaland Region, Sweden, were identified (n = 251), follow-up 14.4 (±8.9) years (mean ± SD), 121 managed medically, 42 treated with myectomy and 88 with short atrioventricular (AV) delay pacing as first interventional procedure. Post-intervention follow-up was 12.9 ± 8.7 years and 12.2 ± 5.0 years, ...
Tópico(s): Cardiovascular Issues in Pregnancy
2017 - Oxford University Press | EP Europace
H. von Prost, Nils Johan Andersson, Al. Ed. Lindblom,
... antecknade 1839—43. (Fortsattning fran nummer 8-9). Nils Johan Andersson: De svenska fjell-arterna af slagtet Epilobium. Al. ...
Tópico(s): Botany and Plant Ecology Studies
1844 - Alexis Eduard Lindblom | Botaniska notiser
Luis Alberto Aranda, Nils-Johan Wessman, Lucana Santos, Alfonso Sánchez‐Macián, Jan Andersson, Roland Weigand, Juan Antonio Maestro,
One of the traditional issues in space missions is the reliability of the electronic components on board spacecraft. There are numerous techniques to deal with this, from shielding and rad-hard fabrication to ad-hoc fault-tolerant designs. Although many of these solutions have been extensively studied, the recent utilization of FPGAs as the target architecture for many electronic components has opened new possibilities, partly due to the distinct nature of these devices. In this study, we performed ...
Tópico(s): VLSI and Analog Circuit Testing
2020 - Multidisciplinary Digital Publishing Institute | Electronics
Johan Hansson, Lennart Ohlsson, Robert Persson, Gunnar Andersson, Nils‐Gunnar Ilbäck, Mark J. Litton, Terje Kalland, Mikael Dohlsten,
Superantigens (SAg) are a family of bacterial and viral proteins with strong immunostimulatory properties. SAg bound to major histocompatibility complex (MHC) class II molecules activate a high frequency of T cells and represent the most potent known activators of T cells to date. To explore the use of SAg for T cell-based tumor therapy we have created a tumor-reactive SAg by engineering a fusion protein composed of a tumor-reactive mAb (C215Fab) and the bacterial SAg staphylococcal enterotoxin A (SEA). ...
Tópico(s): RNA Interference and Gene Delivery
1997 - National Academy of Sciences | Proceedings of the National Academy of Sciences
Helena Ågerstam, Marcus Järås, Anna Andersson, Petra Johnels, Nils Hansen, Carin Lassen, Marianne Rissler, David Gisselsson, Tor Olofsson, Johan Richter, Xiaolong Fan, Mats Ehinger, Thoas Fioretos,
Abstract The 8p11 myeloproliferative syndrome (EMS), also referred to as stem cell leukemia/lymphoma, is a chronic myeloproliferative disorder that rapidly progresses into acute leukemia. Molecularly, EMS is characterized by fusion of various partner genes to the FGFR1 gene, resulting in constitutive activation of the tyrosine kinases in FGFR1. To date, no previous study has addressed the functional consequences of ectopic FGFR1 expression in the potentially most relevant cellular context, that of ...
Tópico(s): Chronic Myeloid Leukemia Treatments
2010 - Elsevier BV | Blood
Nils Berginström, Peter Nordström, Urban Ekman, Johan Eriksson, Micael Andersson, Lars Nyberg, Anna Nordström,
To investigate whether functional magnetic resonance imaging (fMRI) can be used to detect fatigue after traumatic brain injury (TBI).Neurorehabilitation clinic.Patients with TBI (n = 57) and self-experienced fatigue more than 1 year postinjury, and age- and gender-matched healthy controls (n = 27).Self-assessment scales of fatigue, a neuropsychological test battery, and fMRI scanning during performance of a fatiguing 27-minute attention task.During testing within the fMRI scanner, patients showed a higher ...
Tópico(s): Cardiac Arrest and Resuscitation
2017 - Lippincott Williams & Wilkins | Journal of Head Trauma Rehabilitation
Tomas Kirkhorn, M. Kehler, Johan Nilsson, K. Lyttkens, Berth Andersson, Nils‐Gunnar Holmer,
Different digital medical images have been printed on paper with a continuous ink jet printer, and the quality has been evaluated. The emphasis has been on digital chest radiographs from a computed radiography system. The ink jet printing technique is described as well as the handling of the image data from image source to printer. Different versions of paper prints and viewing conditions were compared to find the optimum alternative. The evaluation has been performed to maximize the quality of ...
Tópico(s): Digital Radiography and Breast Imaging
1992 - Springer Science+Business Media | Journal of Digital Imaging
Knut Jørgen Labori, Svein Olav Bratlie, Bodil Andersson, Jon‐Helge Angelsen, Christina Biörserud, Bergþór Björnsson, Erling A. Bringeland, Nils Elander, Herish Garresori, Jon Erik Grønbech, Johan Haux, Oskar Hemmingsson, Maria Gustafsson Liljefors, Tor Åge Myklebust, Linn Såve Nymo, Katriina Peltola, Per Pfeiffer, Ville Sallinen, Per Sandström, Ernesto Sparrelid, Helge Stenvold, Kjetil Søreide, Bobby Tingstedt, Caroline S. Verbeke, Daniel Öhlund, Leif Klint, Svein Dueland, Kristoffer Lassen, Eirik Kjus Aahlin, Charlotte Bratthäll, Asif Halimi, Ingunn Hatlevoll, Margareta Heby, Arto Kokkola, Maximilian Kordes, Stina Lindblad, Linda Lundgren, Michael Bau Mortensen, Kim Erlend Mortensen, Jan Persson, Elena Rangelova, Elin Rønne, Oddvar M. Sandvik, Jon Arne Søreide, Caroline Vilhav, Kim Waardal, Johanna Wennerblom, Caroline Williamsson, Sheraz Yaqub,
Summary Background In patients undergoing resection for pancreatic cancer, adjuvant modified fluorouracil, leucovorin, irinotecan, and oxaliplatin (FOLFIRINOX) improves overall survival compared with alternative chemotherapy regimens. We aimed to compare the efficacy and safety of neoadjuvant FOLFIRINOX with the standard strategy of upfront surgery in patients with resectable pancreatic ductal adenocarcinoma. Methods NORPACT-1 was a multicentre, randomised, phase 2 trial done in 12 hospitals in Denmark, ...
Tópico(s): Hepatocellular Carcinoma Treatment and Prognosis
2024 - Elsevier BV | The Lancet. Gastroenterology & hepatology
Johan Saldeen, David T. Curiel, Décio L. Eizirik, Arne Andersson, Eva Strandell, Karsten Buschard, Nils Welsh,
The establishment of gene delivery systems that result in efficient transfection of the pancreatic β-cells may generate an important tool for the study of IDDM and may also represent one critical step toward a clinical application of gene transfer for the prevention or early treatment of the disease. Using the reporter gene vectors pCAT and pCMV β-gal, we have investigated the efficiency of transfection mediated by calcium phosphate precipitation, the monocationic liposome Lipofectin, the polycationic ...
Tópico(s): Virus-based gene therapy research
1996 - American Diabetes Association | Diabetes
Henrik Hadimeri, Carsten Frisenette‐Fich, S.-I. Deurell, Lars G. Svensson, Lena Carlsson-Bjering, Anders Fernström, Gabriel Almroth, Stefan Melander, Mattias Haarhaus, Per‐Olof Andersson, Agneta Cassel, Nils-Johan Mauritz, Agneta Ståhl-Nilsson, Jan Wilske, Kataryna Nordström, Pavel Oruda, Marie Eriksson, Annelie Inghilesi Larsson, Bernd Stegmayr,
Background: The primary aim of this study was to assess whether a fixed protocol, using a specially trained team, for intermediate follow-up to fulfillment of guideline targets is non-inferior to conventional follow-up in the care of uraemic patients. A secondary aim was to investigate possible impact on patient outcome. Methods: The cohort comprised 424 patients from seven centers. Inclusion criteria were either serum creatinine exceeding 200 µmol/l or calculated clearance below 30 ml/min, representing ...
Tópico(s): Healthcare cost, quality, practices
2013 - Taylor & Francis | Renal Failure
Can T. Xu, Nils‐Olof Svensson, Johan Axelsson, Pontus Svenmarker, Gabriel Somesfalean, Guanying Chen, Huijuan Liang, Haichun Liu, Zhiguo Zhang, Stefan Andersson‐Engels,
Autofluorescence is a nuisance in the field of fluorescence imaging and tomography of exogenous molecular markers in tissue, degrading the quality of the collected data. In this letter, we report autofluorescence insensitive imaging using highly efficient upconverting nanocrystals (NaYF4:Yb3+∕Tm3+) in a tissue phantom illuminated with near-infrared radiation of 85mW∕cm2. It was found that imaging with such nanocrystals leads to an exceptionally high contrast compared to traditional downconverting ...
Tópico(s): Optical Imaging and Spectroscopy Techniques
2008 - American Institute of Physics | Applied Physics Letters
Nils Welsh, Boris A. Margulis, Lisa Borg, Helena Jernberg‐Wiklund, Johan Saldeen, Malin Flodström‐Tullberg, María Alice Rostom de Mello, Arne Andersson, Daniël Pipeleers, Claes Hellerström, Décio L. Eizirik,
It has previously been observed that the insulin-producing cells of human pancreatic islets are more resistant to alloxan-, streptozotocin-, nitroprusside-, or cytokine-induced injury than those of mouse and rat islets.Human pancreatic islets were obtained from heart-beating organ donors. The expression of the stress proteins heat shock protein 70 (hsp70) and heme oxygenase and the anti-apoptosis gene bcl-2 was determined in isolated rat, mouse, and human islets, either cultured in vitro or transplanted ...
Tópico(s): Diabetes and associated disorders
1995 - BioMed Central | Molecular Medicine
Nils Johan Andersson, Tore Ekström,
Zusammenfassung . Die Größe der Ventilation bei künstlicher Atmung mit der Methode von Schäfer und der von Nielsen wurde untersucht. Es wurden Versuche sowohl während willkürlicher Apnöe wie bei normaler Atmung angestellt. Die Versuche wurden nach einer langen Übungsperiode ausgeführt. . Bei künstlicher Atmung unter normalen Atmungsbedingungen liegt eine auffallende Ähnlichkeit mit der Spontanatmung vor. Die Werte bei künstlicher Atmung liegen etwas höher als die entsprechenden Werte bei normaler Atmung, ...
Tópico(s): Respiratory Support and Mechanisms
1940 - Wiley | Skandinavisches Archiv Für Physiologie
... more papers by this author NILS-AKE HILLARP, NILS-AKE HILLARPSearch for more papers by this authorBERNT HÖKFELT, BERNT HÖKFELTSearch for more papers by this author First published: January 1954 https://doi.org/10.1111/j.1748-1716.1954.tb01074.xCitations: 193 1 Aided by grants from Statens Medicinska Forskningsråd and Stiftelsen Thcrese och Johan Anderssons Minne AboutPDF ToolsRequest permissionExport citationAdd to favoritesTrack citation ...
Tópico(s): Cardiovascular and exercise physiology
1954 - Wiley | Acta Physiologica Scandinavica
Per Edlund, Johan Ahlgren, Karsten Bjerre, Michael Andersson, Jonas Bergh, Henning T. Mouridsen, Stig B. Holmberg, Nils‐Olof Bengtsson, Erik Jakobsen, Susanne Møller, Henrik Lindman, Carl Blomqvist,
The SBG 2000-1 trial is a randomised study that investigates if dose-tailored adjuvant FEC therapy based on the individual's leukocyte nadir value can improve outcome. The study has included 1535 women with medium and high-risk breast cancer. Patients and methods. After a first standard dosed FEC course (5-fluorouracil 600 mg/m2, epirubicin 60 mg/mg2 and cyclophosphamide 600 mg/m2), patients who did not reach leukopenia grade III or IV were randomised to standard doses (group standard) or doses tailored ...
Tópico(s): Neutropenia and Cancer Infections
2011 - Taylor & Francis | Acta Oncologica
Stellan Sandler, Annika Andersson, Andreea Barbu, Claes Hellerström, Maria Holstad, Ella Karlsson, Jan-Olov Sandberg, Eva Strandell, Johan Saldeen, Johnny Sternesjö, Linda Tillmar, Décio L. Eizirik, Malin Flodström‐Tullberg, Nils Welsh,
Type 1 diabetes is an autoimmune disease leading to extensive destruction of the pancreatic beta-cells. Our research focusses on the role of beta-cells during the course of the disease, aiming at finding novel strategies to enhance beta-cell resistance against the cytotoxic damage inflicted by the immune system. Special attention has been paid to the possibility that cytokines released by the immune cells infiltrating the pancreatic islets can directly suppress and kill beta-cells. Certain cytokines ( ...
Tópico(s): Diet, Metabolism, and Disease
2000 - Taylor & Francis | Upsala Journal of Medical Sciences
Johan Ahlner, Krister L. Axelsson, Marie Ekstram‐Ljusegren, Richard L. Friedman, Nils Gnindström, J. Karlsson, Rolf G. G. Andersson,
Abstract: Low concentrations (< 1 nM) of glyceryl trinitrate (GTN) induced a considerable relaxation of bovine mesenteric arteries (BMA) brought to sustained contraction by the addition of phenylephrine. The concentration‐response curve of GTN showed a biphasic pattern with a high and a low affinity component. Pretreatment with pertussis toxin (IAP) attenuated the high affinity relaxant component, but not the low affinity component or the relaxation induced by NaNO 2 . A polyclonal antibody to IAP counteracted ...
Tópico(s): Renin-Angiotensin System Studies
1988 - Wiley | Pharmacology & Toxicology
Nils Fagerberg, Jan-Ola Olsson, Peter Lohmander, M. Andersson, Johan Bergh,
Abstract Individual tree selection (ITS) is one option to manage uneven-sized forest ecosystems. However, scientifically based field guidelines adapted to ITS and economic profitability are rare, often because there is a lack of suitable tree models to use in growth and treatment simulations. The objective of this study is to develop individual-tree distance-dependent growth models focusing on Norway spruce dominated uneven-sized stands. Three models of different complexity, but with the same structural ...
Tópico(s): Plant Water Relations and Carbon Dynamics
2022 - Oxford University Press | Forestry An International Journal of Forest Research
Sangeet Lamichhaney, Álvaro Martínez Barrio, Nima Rafati, Görel Sundström, Carl‐Johan Rubin, Elizabeth R. Gilbert, Jonas Berglund, Anna Wetterbom, Linda Laikre, Matthew T. Webster, Manfred Grabherr, Nils Ryman, Leif Andersson,
The Atlantic herring ( Clupea harengus ), one of the most abundant marine fishes in the world, has historically been a critical food source in Northern Europe. It is one of the few marine species that can reproduce throughout the brackish salinity gradient of the Baltic Sea. Previous studies based on few genetic markers have revealed a conspicuous lack of genetic differentiation between geographic regions, consistent with huge population sizes and minute genetic drift. Here, we present a cost-effective ...
Tópico(s): Genomics and Phylogenetic Studies
2012 - National Academy of Sciences | Proceedings of the National Academy of Sciences
Susanna von Holst, Simone Picelli, David Edler, Claes Lenander, Johan Dalén, Fredrik Hjern, Nils Lundqvist, Ulrik Lindforss, Lars Påhlman, Kenneth Smedh, Anders Törnqvist, Jörn Holm, Martin Janson, Magnus Andersson, S Tumlin Ekelund, Lisen Båverud Olsson, Sam Ghazi, Nikos Papadogiannakis, Albert Tenesa, Susan M. Farrington, Harry Campbell, Malcolm G. Dunlop, Annika Lindblom,
Recently, several genome-wide association studies (GWAS) have independently found numerous loci at which common single-nucleotide polymorphisms (SNPs) modestly influence the risk of developing colorectal cancer. The aim of this study was to test 11 loci, reported to be associated with an increased or decreased risk of colorectal cancer: 8q23.3 (rs16892766), 8q24.21 (rs6983267), 9p24 (rs719725), 10p14 (rs10795668), 11q23.1 (rs3802842), 14q22.2 (rs4444235), 15q13.3 (rs4779584), 16q22.1 (rs9929218), 18q21.1 ( ...
Tópico(s): Colorectal Cancer Screening and Detection
2010 - Springer Nature | British Journal of Cancer
Simone Picelli, Paweł Zając, Xiaolei Zhou, David Edler, Claes Lenander, Johan Dalén, Fredrik Hjern, Nils Lundqvist, Ulrik Lindforss, Lars Påhlman, Kenneth Smedh, Anders Törnqvist, Jörn Holm, Martin Janson, Magnus Andersson, S Tumlin Ekelund, Louise Olsson, Joakim Lundeberg, Annika Lindblom,
The genetic susceptibility to colorectal cancer (CRC) has been estimated to be around 35% and yet high-penetrance germline mutations found so far explain less than 5% of all cases. Much of the remaining variations could be due to the co-inheritance of multiple low penetrant variants. The identification of all the susceptibility alleles could have public health relevance in the near future. To test the hypothesis that what are considered polymorphisms in human CRC genes could constitute low-risk alleles, ...
Tópico(s): Genomic variations and chromosomal abnormalities
2010 - Elsevier BV | European Journal of Cancer
Álvaro Martínez Barrio, Sangeet Lamichhaney, Guangyi Fan, Nima Rafati, Mats E. Pettersson, He Zhang, Jacques Dainat, Diana Ekman, Marc P. Höppner, Patric Jern, Marcel Martin, Björn Nystedt, Xin Liu, Wenbin Chen, Xinming Liang, Chengcheng Shi, Yuanyuan Fu, Kailong Ma, Xiao Zhan, Chungang Feng, Ulla Gustafson, Carl‐Johan Rubin, Markus Sällman Almén, Martina Blass, Michele Casini, Arild Folkvord, Linda Laikre, Nils Ryman, Simon Ming‐Yuen Lee, Xun Xu, Leif Andersson,
Ecological adaptation is of major relevance to speciation and sustainable population management, but the underlying genetic factors are typically hard to study in natural populations due to genetic differentiation caused by natural selection being confounded with genetic drift in subdivided populations. Here, we use whole genome population sequencing of Atlantic and Baltic herring to reveal the underlying genetic architecture at an unprecedented detailed resolution for both adaptation to a new niche ...
Tópico(s): Genetic and phenotypic traits in livestock
2016 - eLife Sciences Publications Ltd | eLife
Tópico(s): Multiculturalism, Politics, Migration, Gender
2001 - Éditions Gallimard | Les Temps Modernes
A propos de : Chloe Maurel, Une breve histoire de l'ONU au fil de ses dirigeants, Editions du Croquant
Tópico(s): Global Peace and Security Dynamics
2017 - | La Vie des idées.fr/La Vie des idées
Tópico(s): Political and Social Issues
1996 - Éditions Gallimard | Les Temps Modernes