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Artigo Brasil Produção Nacional Revisado por pares

Rodrigo Pires dos Santos, Camila Hubner Dalmora, Stephani A Lukasewicz, Otávio Luiz da Fontoura Carvalho, Caroline Deutschendorf, Raquel Barbosa de Lima, Tiago Leitzke, Nilson C Correa, Marcelo V Gambetta,

Introduction Telemedicine technologies are increasingly being incorporated into infectious disease practice. We aimed to demonstrate the impact of antimicrobial stewardship through telemedicine on bacterial resistance rates. Methods We conducted a quasi-experimental study in a 220-bed hospital in southern Brazil. An antimicrobial stewardship program incorporating the use of telemedicine was implemented. Resistance and antimicrobial consumption rates were determined and analysed using a segmented ...

Tópico(s): Urinary Tract Infections Management

2018 - SAGE Publishing | Journal of Telemedicine and Telecare

Carta Acesso aberto Brasil Produção Nacional

Carmen Dolores Gonçalves Brandão, Angélica Espinosa Miranda, Nilson Duarte Corrêa, Lino Sieiro Netto, Rossana Corbo, Mário Vaisman,

OBJECTIVES: To evaluate abortion and fetal congenital anomaly rates in women previously submitted to radioiodine therapy for differentiated thyroid carcinoma. STUDY DESIGN: A case-control study of 108 pregnant women, 48 cases whose pregnancies were evaluated after they had undergone radioiodine therapy for differentiated thyroid carcinoma, and the control group consisted of 60 healthy pregnant women. RESULTS: Of a total of 66 pregnancies, 14 conceived within the first year, 51 one or more years ...

Tópico(s): BRCA gene mutations in cancer

2007 - Editora da Universidade de São Paulo | Arquivos Brasileiros de Endocrinologia & Metabologia

Artigo Acesso aberto Brasil Produção Nacional Revisado por pares

Nilson César Corrêa Padilha, M. do S. P. de Oliveira, M. G. da C. Mota,

No melhoramento da pupunheira, visando a produção de palmito, é primordial o conhecimento de parâmetros genéticos de caracteres produtivos associados aos morfológicos na seleção de plantas promissoras. Por ser uma palmeira perene com caráter de produção destrutivo, o coeficiente de repetibilidade consiste em uma estratégia desejável. Assim, estimou-se o coeficiente de repetibilidade entre oito caracteres morfológicos e oito de produção de palmito em pupunheiras da coleção de germoplasma da Embrapa ...

Tópico(s): Agricultural and Food Sciences

2003 - Sociedade de Investigações Florestais | Revista Árvore

Artigo Acesso aberto Brasil Produção Nacional Revisado por pares

Mabel Nilson Alves, Ludmila Corrêa Muniz, Maria de Fátima Alves Vieira,

O objetivo deste estudo foi descrever características do consumo alimentar de crianças brasileiras e sua associação com fatores sociodemográficos. Foram analisados os dados de consumo alimentar da Pesquisa Nacional de Demografia e Saúde da Criança e da Mulher realizada em 2006. A análise considerou a complexidade amostral e incluiu 3.083 crianças de dois a cinco anos de idade. O desfecho foi avaliado a partir de marcadores alimentares. As estimativas desses marcadores foram descritas segundo sexo ...

Tópico(s): Indigenous Health and Education

2013 - ASSOCIAÇÃO BRASILEIRA DE SAÚDE COLETIVA | Ciência & Saúde Coletiva

Artigo Acesso aberto Brasil Produção Nacional Revisado por pares

Carmen Dolores Gonçalves Brandão, Jane B. Antonucci, Nilson Duarte Corrêa, Rossana Corbo, Mário Vaisman,

A radioiodoterapia tem conseguido desempenhar um papel significante no tratamento do carcinoma diferenciado de tireóide. A literatura é limitada em relação a possíveis efeitos secundários do 131I, embora o interesse tenha aumentado nesse campo. A importância de se saber mais sobre os efeitos mutagênicos da radiação em filhos de mães expostas ao 131I para tratamento do carcinoma diferenciado de tireóide é devida à possibilidade de ocorrência de abortos, anormalidades genéticas e aparecimento de malignidades ...

Tópico(s): Effects of Radiation Exposure

2004 - Colégio Brasileiro de Radiologia e Diagnóstico por Imagem | Radiologia Brasileira

Artigo Acesso aberto Brasil Produção Nacional Revisado por pares

Wallax Augusto Silva Ferreira, Mariana Diniz Araújo, Nilson Praia Anselmo, Edivaldo Herculano Corrêa de Oliveira, José Reginaldo Nascimento Brito, Rommel Mário Rodríguez Burbano, Maria Lúcia Harada, Bárbara do Nascimento Borges,

Astrocytic gliomas, which are derived from glial cells, are considered the most common primary neoplasias of the central nervous system (CNS) and are histologically classified as low grade (I and II) or high grade (III and IV). Recent studies have shown that astrocytoma formation is the result of the deregulation of several pathways, including the RB/E2F pathway, which is commonly deregulated in various human cancers via genetic or epigenetic mechanisms. On the basis of the assumption that the study ...

Tópico(s): Hedgehog Signaling Pathway Studies

2015 - Public Library of Science | PLoS ONE

Artigo Acesso aberto Brasil Produção Nacional Revisado por pares

Cleber Nunes Corrêa, Nilson Reinaldo Fernandes dos Santos, Wanderson Cleiton Schmidt Cavalheiro, Raymundo Leite da Silva Júnior, Eduardo Ossamu Nagao, Jhony Vendruscolo,

Conhecer as características da paisagem é o primeiro passo para se identificar as potencialidades e limitações de uma região, e, consequentemente, planejar e gerir adequadamente os recursos naturais. Portanto, objetivou-se com este trabalho, realizar a caracterização hidrogeomorfométrica da microbacia do rio Maritaca, para fornecer informações básicas ao planejamento do desenvolvimento sustentável. Foram analisados os parâmetros hidrogeomorfométricos, utilizando os softwares Google Earth, QGIS e ...

Tópico(s): Groundwater and Watershed Analysis

2021 - Grupo de Pesquisa Metodologias em Ensino e Aprendizagem em Ciências | Research Society and Development

Revisão Acesso aberto Brasil Produção Nacional Revisado por pares

Márcio Alexandre Terra Passos, Fernanda Correa Chaves, Nilson CHAVES-JUNIOR,

ABSTRACT Introduction: Endoscopic evaluation, particularly the macroscopic mucosal and histological results of ileocolic biopsies, is essential for the management of inflammatory bowel disease. Endoscopic appearance is not always sufficient to differentiate Crohn’s disease and ulcerative colitis, but there are some characteristics that favor one or another diagnosis. Both diseases have an increased incidence of colorectal carcinoma; so, surveillance colonoscopy is important for detecting early neoplastic ...

Tópico(s): Colorectal Cancer Screening and Detection

2018 - Colégio Brasileiro de Cirurgia Digestiva | ABCD Arquivos Brasileiros de Cirurgia Digestiva (São Paulo)

Artigo Acesso aberto Brasil Produção Nacional Revisado por pares

Ana Paula Alves Valle Dornas, Frederico Thadeu Assis Figueiredo Campos, Cláudia Juliana Rezende, Carlos Alberto Ribeiro, Nilson Figueiredo Amaral, Ricardo de Amorim Corrêa,

O sarcoma intimal de artéria pulmonar é um tumor raro e potencialmente letal, de diagnóstico difícil e, muitas vezes, tardio. Os sinais e sintomas clínicos são inespecíficos, simulando com frequência o tromboembolismo pulmonar crônico (TEPC). Apresentamos o caso de um homem de 45 anos em tratamento de TEPC associado com hipertensão arterial pulmonar e cor pulmonale crônico, sem resposta ao uso de anticoagulantes e sildenafil. Ressaltamos as dificuldades para o diagnóstico do sarcoma intimal de artéria ...

Tópico(s): Venous Thromboembolism Diagnosis and Management

2009 - Sociedade Brasileira de Pneumologia e Tisiologia | Jornal Brasileiro de Pneumologia

Artigo Acesso aberto Brasil Produção Nacional Revisado por pares

Tarcília Henrique Amaral Corrêa, José Nilson França de Holanda,

Abstract Calcium pyrophosphate (CPP) was prepared by a simple precipitation method using avian eggshell waste as a low-cost alternative calcium precursor source. The synthesized CPP powder was characterized by X-ray diffraction (XRD), scanning electron microscopy (SEM/EDS), thermogravimetric analysis (TGA), and Fourier transform infrared spectroscopy (FTIR). The results indicate that pure β-CPP nanocrystallites (Ca/P = 1.067) were successfully synthesized from avian eggshell waste. The correlation among ...

Tópico(s): Nanoparticles: synthesis and applications

2016 - Associação Brasileira de Cerâmica | Cerâmica

Artigo Acesso aberto Brasil Produção Nacional Revisado por pares

Tarcília Henrique Amaral Corrêa, José Nilson França de Holanda,

Fish bone is rich in calcium carbonate, which makes it an alternative source of low cost calcium carbonate for the synthesis of calcium phosphate bioceramic for use in bone regeneration. The calcium phosphate bioceramic was prepared by a wet precipitation method with acid and base reactions. The synthesized bioceramic was characterized in terms of X-ray diffraction (XRD), scanning electron microscopy (SEM/EDS), thermogravimetric analysis (TGA), Fourier transform infrared spectroscopy (FTRI), average ...

Tópico(s): Endodontics and Root Canal Treatments

2019 - Associação Brasileira de Metalurgia e Materiais (ABM); Associação Brasileira de Cerâmica (ABC); Associação Brasileira de Polímer | Materials Research

Artigo Acesso aberto Brasil Produção Nacional

Guilherme Nilson Alves dos Santos, Yara Teresinha Corrêa Silva‐Sousa, A. Alonso, Aline Evangelista Souza‐Gabriel, Alice Corrêa Silva‐Sousa, Fabiane Carneiro Lopes‐Olhê, Renato Roperto, Jardel Francisco Mazzi‐Chaves, Manoel Damião Sousa‐Neto,

To evaluate the push-out bond strength of the adjustable fiberglass post system to dentin. Twenty maxillary canine roots were endodontically treated and divided into two groups (n=10): conventional fiberglass posts (CFPs) and with single adjustable post (SAP) system. Two slices of each third were subjected to the push-out and failure pattern test and the most apical slice was subjected to analysis of the adhesive interface by scanning electron microscopy (SEM). Data were analyzed by the three-way analysis ...

Tópico(s): Dental Implant Techniques and Outcomes

2023 - Japanese Society for Dental Materials and Devices | Dental Materials Journal

Artigo Brasil Produção Nacional Revisado por pares

Jhuliene Elen Muro Torrento, Carlos Roberto Grandini, Tiago dos Santos Pereira de Sousa, L.A. Rocha, Tatiana Maria Gonçalves, Lívia Sottovia, Elidiane Cipriano Rangel, Nilson Cristino da Cruz, Diego Rafael Nespeque Corrêa,

This study investigated the effect of silver addition and micro-arc oxidation (MAO) treatment on the microstructure, selected mechanical properties, and surface characteristics of the Ti-15Zr-15Mo (wt%) alloy. The ingots were produced by argon arc-melting and subsequently subjected to thermomechanical treatments and surface modification. Phase composition and microstructure of the samples exhibited only the β phase. The samples possessed better mechanical biocompatibility (in terms of Vickers microhardness ...

Tópico(s): Orthopaedic implants and arthroplasty

2020 - Elsevier BV | Materials Letters

Artigo Acesso aberto Brasil Produção Nacional Revisado por pares

Nádia Marcuz, Rafael Parra Ribeiro, Elidiane Cipriano Rangel, Nilson Cristino da Cruz, Diego Rafael Nespeque Corrêa,

Fe-based materials have extensive applications in the building and automobile industries due to their excellent mechanical properties and low cost. However, their biomedical employment is restricted by the corrosion propensity when in contact with bodily fluids. In this study, single-step Plasma Electrolytic Oxidation, PEO, treatment in Ta-rich electrolyte was used, for the first time, to improve the corrosion resistance of low-carbon steel SAE 1020 for possible use as device implants. The effect ...

Tópico(s): Orthopaedic implants and arthroplasty

2023 - Multidisciplinary Digital Publishing Institute | Metals

Artigo Acesso aberto Brasil Produção Nacional Revisado por pares

Sérgio André Lopes Quaresma, Guilherme Nilson Alves dos Santos, Alice Corrêa Silva‐Sousa, Rafael Verardino de Camargo, Yara Teresinha Corrêa Silva‐Sousa, Fabiane Carneiro Lopes‐Olhê, Jardel Francisco Mazzi‐Chaves, Manoel Damião Sousa‐Neto,

To evaluate the bond strength (BS) and analysis of the adhesive interface in root canals filled with bioceramic gutta percha sealers and cones. Ninety-six maxillary canines were divided into eight groups according to the endodontic sealer (AH Plus, AH Plus Bioceramic, Bio-C Sealer or Bio-C Sealer Ion+ and gutta percha cones (conventional or bioceramic) tested. They were analyzed using the BS test, failure pattern, analysis of the adhesive interface by scanning electron microscopy and confocal laser ...

Tópico(s): Dental Radiography and Imaging

2023 - Springer Nature | Clinical Oral Investigations

Artigo Acesso aberto Brasil Produção Nacional Revisado por pares

Joana Aurora Braun Chagas, Nilson Oleskovicz, Aury Nunes de Moraes, Fabíola Niederauer Flôres, André Luís Corrêa, Júlio C. Souza Júnior, André Vasconcelos Soares, Átila Costa,

O objetivo deste estudo foi avaliar o protocolo de contenção química com cetamina S(+) e midazolam em bugios-ruivos, comparando o cálculo de doses pelo método convencional e o método de extrapolação alométrica. Foram utilizados 12 macacos bugios (Alouatta guariba clamitans) hígidos, com peso médio de 4,84±0,97kg, de ambos os sexos. Após jejum alimentar de 12 horas e hídrico de seis horas, realizou-se contenção física manual e aferiram-se os seguintes parâmetros: frequência cardíaca (FC), frequência ...

Tópico(s): Antibiotics Pharmacokinetics and Efficacy

2010 - UNIVERSIDADE FEDERAL DE SANTA MARIA | Ciência Rural

Artigo Brasil Produção Nacional Revisado por pares

Gunther Ricardo Bertolini, Guilherme Nilson Alves dos Santos, Francisco Wanderley Garcia Paula‐Silva, Alice Corrêa Silva‐Sousa, Renato Roperto, Manoel Damião Sousa‐Neto, Fabiane Carneiro Lopes‐Olhê,

• Higher BS was found for MFPs compared to conventional fiberglass posts. • Ultrasonic tip filling removal results in higher BS and better adaptation of MFPs. • Highest BS was found for the use of ultrasonic tip with surgical microscopy.

Tópico(s): Surgical Sutures and Adhesives

2022 - Elsevier BV | Journal of the mechanical behavior of biomedical materials/Journal of mechanical behavior of biomedical materials

Artigo Brasil Produção Nacional Revisado por pares

Nilson C. Ferreira‐Junior, Alessandra G. Fedoce, Fernando H.F. Alves, Fernando Morgan de Aguiar Corrêa, Leonardo B.M. Resstel,

Neural reflex mechanisms, such as the baroreflex, are involved in the regulation of cardiovascular system activity. Previous results from our group (Resstel LB, Correa FM. Medial prefrontal cortex NMDA receptors and nitric oxide modulate the parasympathetic component of the baroreflex. Eur J Neurosci 23: 481-488, 2006) have shown that glutamatergic synapses in the ventral portion of the medial prefrontal cortex (vMPFC) modulate baroreflex activity. Moreover, glutamatergic neurotransmission in the ...

Tópico(s): Neuroscience of respiration and sleep

2011 - American Physiological Society | AJP Regulatory Integrative and Comparative Physiology

Artigo Brasil Produção Nacional Revisado por pares

Nilson Camargo Roso, Rosana Rosa Miranda Corrêa, Yara Marcondes Machado Castiglia, Lídia Raquel de Carvalho, Lúcia Marina Scatena, Aparecida Vitória Gonçalves de Souza, Cristiano Claudino Oliveira, Pedro Thadeu Galvão Vianna,

The purpose of this investigation was to examine the effect of caffeic acid phenethyl ester (CAPE) in renal ischemia/reperfusion injury in rats anesthetized with isoflurane (iso).We randomly assigned 26 male Wistar rats anesthetized with isoflurane, intubated and mechanically ventilated to 3 groups: G1 (controls; n = 8), G2 (CAPE; n = 10), and G3 (ethanol; n = 8). Mean arterial pressure was monitored for anesthetic control. Intraperitoneal CAPE (G2) or ethanol (G3) injections were administered 40 minutes before ...

Tópico(s): Veterinary Pharmacology and Anesthesia

2012 - Elsevier BV | Transplantation Proceedings

Artigo Acesso aberto Brasil Produção Nacional Revisado por pares

Eduardo Albino Trindade Fortaleza, Nilson C. Ferreira‐Junior, Davi C. Lagatta, Leonardo B.M. Resstel, Fernando Morgan de Aguiar Corrêa,

The medial amygdaloid nucleus (MeA) is involved in cardiovascular control. In the present study we report the effect of MeA pharmacological ablations caused by bilateral microinjections of the nonselective synaptic blocker CoCl2 on cardiac baroreflex responses in rats. MeA synaptic inhibition evoked by local bilateral microinjection of 100 nL of CoCl2 (1 mM) did not affect blood pressure or heart rate baseline, suggesting no tonic MeA influence on resting cardiovascular parameters. However, 10 min ...

Tópico(s): Neurotransmitter Receptor Influence on Behavior

2015 - Elsevier BV | Autonomic Neuroscience

Artigo Acesso aberto Brasil Produção Nacional Revisado por pares

Danielle Cristina Netto Rodrigues, Ruffo Freitas‐Júnior, Rosemar Macedo Sousa Rahal, Rosângela da Silveira Corrêa, Joäo Emílio Peixoto, Noely Vicente Ribeiro, Nilson Clementino Ferreira, Leonardo Ribeiro Soares,

Background: Factors that may hamper access to mammographic screening in any given region include socioeconomic limitations and the geographical distribution and quality of the mammography machines. This study evaluated access to breast cancer screening within the Brazilian National Health Service (SUS), the geographical distribution of mammography equipment and the number of mammograms performed in Brazil. Methods: This ecological study evaluated the availability of mammography machines within the ...

Tópico(s): Colorectal Cancer Screening and Detection

2019 - West Asia Organization for Cancer Prevention | Asian Pacific Journal of Cancer Prevention

Artigo Acesso aberto

Neuza B. C. de Araújo, Nilton C. de Araujo Filho, Aida Begami Leal, Nair F. Rey Cardoso, Nilson Duarte Corrêa,

O infarto muscular diabético (IMD) é uma complicação incomum do diabetes (DM) de longa duração. Esta condição pode ocorrer em pacientes com DM tipo 1 ou 2 mal controlados, com presença de microangiopatia. O quadro clínico é de dor aguda e intensa com edema do músculo afetado, que persiste por muitas semanas e tem melhora espontânea. Apesar de incerta, a etiologia é atribuída à microangiopatia com oclusão das pequenas artérias. É diagnosticado por biópsia, embora os achados em T2 na ressonância magnética ...

Tópico(s): Diabetic Foot Ulcer Assessment and Management

2004 - Editora da Universidade de São Paulo | Arquivos Brasileiros de Endocrinologia & Metabologia

Artigo Acesso aberto Brasil Produção Nacional Revisado por pares

Bianca A. Ferreira, Elizabeth M. Coser, S. Roca, Juliana Ide Aoki, Nilson Branco, Gustavo Henrique Corrêa Soares, Mayara Ingrid Sousa Lima, Adriano C. Coelho,

In Brazil, Leishmania amazonensis is the etiological agent of cutaneous and diffuse cutaneous leishmaniasis. The state of Maranhão in the Northeast of Brazil is prevalent for these clinical forms of the disease and also has high rates of HIV infection. Here, we characterized the drug susceptibility of a L . amazonensis clinical isolate from a 46-year-old man with diffuse cutaneous leishmaniasis coinfected with HIV from this endemic area. This patient underwent several therapeutic regimens with meglumine ...

Tópico(s): Trypanosoma species research and implications

2024 - Public Library of Science | PLoS neglected tropical diseases

Artigo Acesso aberto Brasil Produção Nacional Revisado por pares

D.S. Vasconcelos, F.P.E. da Silva, Luciana Gonçalves Quintana, Nilson Praia Anselmo, Moneeb A. K. Othman, Thomas Liehr, Edivaldo Herculano Corrêa de Oliveira,

Breast cancer is the second most common origin of brain metastases, after lung cancer, and represents 14-20% of all cases.Abnormalities of chromosome 17 are important molecular genetic events in human breast cancer, and several oncogenes and tumor suppressor genes are located on this chromosome.In about half of all human cancers, the tumor suppressor gene TP53, located at 17p13, is D.S. Vasconcelos et al. ©FUNPEC-RP www.funpecrp.com.brGenetics and Molecular Research (2013) Ahead of Printeither lost ...

Tópico(s): Lung Cancer Treatments and Mutations

2013 - Research Foundation of Ribeirão Preto | Genetics and Molecular Research

Artigo Brasil Produção Nacional Revisado por pares

Sérgio André Lopes Quaresma, Guilherme Nilson Alves dos Santos, Alice Corrêa Silva‐Sousa, Rafael Verardino de Camargo, Fabiane Carneiro Lopes‐Olhê, Yara Teresinha Corrêa Silva‐Sousa, Jardel Francisco Mazzi‐Chaves, Manoel Damião Sousa‐Neto,

To mensure the physicochemical properties of three ceramic cement endodontic sealers AH Plus Bioceramic, Bio-C Sealer and Bio-C Sealer Ion+ with an epoxy resin sealer, AH Plus. These properties were measured: hardening time (HT), dimensional change (DC), solubility (SL), flow (FL) and radiopacity (RD). The distilled water obtained from the SL test was analyzed with atomic absorption spectrometry. A sample calculation was made considering n = 5 repetitions for each experimental sealer evaluated. Statistical ...

Tópico(s): Dental materials and restorations

2024 - Elsevier BV | Journal of the mechanical behavior of biomedical materials/Journal of mechanical behavior of biomedical materials

Artigo Acesso aberto Brasil Produção Nacional Revisado por pares

Lúbia Cristina Fonseca, Natássia Caroline Resende Corrêa, Mário da Silva Garrote-Filho, Cleine Chagas da Cunha, Nilson Penha‐Silva,

AQUEOUS SOLUTIONS.A protein presents a native (N) macro state, which is functionally active, in equilibrium with the denatured (D) macro state, which is devoid of biological activity.An ensemble of microstates forms each macrostate.The denatured state comprises a greater ensemble of microstates than the native macrostate.The N-D equilibrium can be affected by several factors, that comprise the purity of the water, temperature, pH and solute concentration.This work discusses the influence of osmolytes ...

Tópico(s): Enzyme Catalysis and Immobilization

2006 - Brazilian Chemical Society | Química Nova

Artigo Acesso aberto Brasil Produção Nacional Revisado por pares

Cristiane Busnardo, Nilson C. Ferreira‐Junior, Josiane C. Cruz, Benedito H. Machado, Fernando Morgan de Aguiar Corrêa, Leonardo B.M. Resstel,

We hypothesize that a local ATP-NO-NMDA glutamate receptor interaction in the paraventricular nucleus (PVN) modulates the baseline mean arterial pressure and heart rate in unanaesthetized rats. The microinjection of α,β-methylene ATP [methyl ATP; 0.06, 0.12 and 1.2 nmol (100 nl)(-1)] into the PVN caused pressor and tachycardiac responses. Cardiovascular responses evoked by methyl ATP [0.12 nmol (100 nl)(-1)] in the PVN were blocked by pretreatment with the ganglion blocker pentolinium (5 mg kg(-1) i.v.). ...

Tópico(s): Neuroendocrine regulation and behavior

2013 - Wiley | Experimental Physiology

Artigo Acesso aberto Brasil Produção Nacional Revisado por pares

Jhuliene Elen Muro Torrento, Tiago dos Santos Pereira de Sousa, Nilson Cristino da Cruz, Gerson Santos de Almeida, Willian Fernando Zambuzzi, Carlos Roberto Grandini, Diego Rafael Nespeque Corrêa,

This study produced non-equiatomic TiNbZrTaMn and TiNbZrTaMo high entropy alloy (HEAs) by argon arc-melting and heat-treated for microstructural homogenization. The phase composition, microstructure, and selected mechanical properties were measured and compared with theoretical predictions. Additionally, electrochemical and cytotoxicity tests evaluated their potential applicability for use as biomaterials. X-ray diffraction measurements patterns showed a single BCC phase for the TiNbZrTaMn and a ...

Tópico(s): Additive Manufacturing Materials and Processes

2022 - American Institute of Physics | APL Materials