Toshiaki Nakashima, Yoshifumi Seto, Toshikazu Nakajima, Toshihide Shima, Yoshikuni Sakamoto, Ninko Cho, Atsushi Sano, Masaki Iwai, Keizo Kagawa, Takeshi Okanoue, Kei Kashima,
Our study was designed to determine the calcium and oxygen paradoxes in isolated rat hepatocytes, and to evaluate the cytoprotective effects of taurine on hepatocytes during oxygenation, hypoxia, and on these paradoxes. The calcium and oxygen paradoxes were clearly revealed in isolated rat hepatocytes. As the formation of the superoxide radical was accelerated by the hyperbaric conditions and the calcium ions, drugs such as superoxide dismutase and a calcium channel blocking agent (verapamil), prevented ...
Tópico(s): Heme Oxygenase-1 and Carbon Monoxide
1990 - Wiley | Liver International
D.J Kim, Ninko Cho, Jung Hyun Noh, M.-S Lee, Myung-Shin Lee, K.-W Kim,
The purpose of this study was to assess the familial clustering of type 2 diabetes and to investigate the presence of excess maternal transmission of type 2 diabetes in Korea. The medical records of 56,492 subjects (31,680 men and 24,812 women), who attended the Health Promotion Center were examined. The subjects were questioned about their parents' diabetes status. All study subjects were classified into the three groups (normal fasting glucose (NFG), impaired fasting glucose (IFG), and diabetes). ...
Tópico(s): Diabetes and associated disorders
2004 - Elsevier BV | Diabetes Research and Clinical Practice
Ninko Radenković, Marina D. Kostić, Nataša Đorđević, Zana Dolićanin, Tanja Soldatović, Marko Živanović, Vera M. Divac,
Herein we report the synthesis of new trans-bis(2-phenylselenylmethyl)oxolane)dichloroplatinum(II) complex Pt1. Newly synthetized complex, together with two, structurally related trans-Pd(II) complexes (trans-bis(2-(phenylselenylmethyl)oxolane)dichloropalladium(II) Pd1 and trans-bis(2-(phenylselenylmethyl)oxane)dichloropalladium(II)) Pd2, were screened for cytotoxic activity through in vitro study on the HCT-116 colorectal carcinoma cell line and on the MRC-5 healthy lung pleura cell line. Activity ...
Tópico(s): Synthesis of Tetrazole Derivatives
2020 - | Macedonian Journal of Chemistry and Chemical Engineering
Anica Kurzbach, Diana M. Willmes, Tina Schumann, Christine Henke, Nermeen N. El-Agroudy, André Kleinridders, Andreas L. Birkenfeld,
... energy homeostasis. We generated a neuronal mIndy knockout (NINKO) mouse model by crossing mIndy-floxed to NestinCre ... 0.5 kcal/h/kg lean mass (lm); NINKO: 13.6±0.6 kcal/h/kg lm; ... NestinCre mice to 0.77±0.01 in NINKO mice during the light phase (p<0.001), indicating augmented lipid oxidation in NINKO mice. Body temperature increased in NINKO compared to NestinCre mice (NestinCre: 37.0±0.1°C, NINKO: 37.3±0.1°C at 6pm; p& ... was reduced and lean mass increased significantly in NINKO mice (NestinCre: 60±1% lm, 31±1% fat ...
Tópico(s): Apelin-related biomedical research
2018 - American Diabetes Association | Diabetes
Anica Kurzbach, Mareike Schell, Diana M. Willmes, Nermeen N. El-Agroudy, André Kleinridders, Andreas L. Birkenfeld,
... and insulin resistance. Generation of neuronal mIndy-KO (NINKO) mice revealed improved insulin sensitivity (IS) in these ... performed to assess IS after hepatic vagotomy of NINKO mice. NestinCre+ controls were sham-denervated. Ex vivo ... with that, AMPK phosphorylation in the HTM of NINKO mice was significantly reduced (-68.1%, p≤0. ... hepatic glucose output (%); NestinCre+: 100.0±27.2, NINKO: 99.4±8.8). Conclusion: These data suggest ...
Tópico(s): Regulation of Appetite and Obesity
2020 - American Diabetes Association | Diabetes
... cveiiing to reply, to aiiy criticisms I might ninko on his views.Therc arc, I believe, few ...
Tópico(s): European and International Law Studies
1867 - Taylor & Francis | Royal United Services Institution Journal
... Tintonictm 1 found tlint it \vns possible to ninko ghtsacs of clilTcrcnt V J L ~R J ...
Tópico(s): Inorganic and Organometallic Chemistry
1910 - Wiley | Journal of the Society of Chemical Industry
M. D. Rvovic, Vera M. Divac, Ninko Radenković, Zorica Bugarčić,
Tópico(s): Vanadium and Halogenation Chemistry
2011 - De Gruyter | Zeitschrift für Naturforschung B
Aleksas Girdenis, Vida Karosienė,
... pasinaudota originaliais Platelių šnektos tyrimais, atliktais savamokslio kalbininko Liudviko Razmos. Iš jų taip pat matyti, kad ...
Tópico(s): Linguistics, Language Diversity, and Identity
2011 - Vilnius University | Baltistica
Jadranka Mrsik, Ninko Kostovski,
The aim of this paper is to explore the viability of off-shoring of accounting services to foreign companies by providers of such services located in Republic of Macedonia. We have assessed the potentials of accountants in Republic of Macedonian to offer off-shored accounting services by using the criteria for assessment of outsourcing destinations in general as established by the McKinsey Institute. We have founded that there is considerable potentials for off-shoring of accounting and related ...
Tópico(s): Outsourcing and Supply Chain Management
2017 - Bucharest Academy of Economic Studies | Journal of Accounting and Management Information Systems
Valdemaras Makutėnas, Aurelija Šukienė,
... būti efektyvi ir tapti ne tik paties ūki-ninko, bet ir kooperatyvo, kuriam jis priklauso, siekiu. Todėl ...
Tópico(s): Working Capital and Financial Performance
2017 - Vytautas Magnus University Agriculture Academy | Management Theory and Studies for Rural Business and Infrastructure Development
Industrial clusters have various forms and in their essence, are very dynamic concepts. According to Porter, they are spatial concentrations of interrelated enterprises, suppliers, knowledge workers, universities and research and development institutions, that establishing and maintaining intense linkages between them, create their competitive advantages in relation with the enterprises that are out of the agglomeration (Porter, 1989).
Tópico(s): Polish socio-economic development
2009 - RELX Group (Netherlands) | SSRN Electronic Journal
Ninko Kostovski, Milen Baltov,
What makes the entrepreneurship among the academia so special? Do the world of science and the business live their own lives in the transition countries such as Bulgaria and Macedonia?
Tópico(s): Entrepreneurship Studies and Influences
2010 - RELX Group (Netherlands) | SSRN Electronic Journal
Entrepreneurship is listed among the key competencies of the new generations. It is essential trait for the young people in the new, fast changing environment, no matter shell they link their careers with the small business or not. Consequently, the education systems can substantially contribute to the successful promotion of the entrepreneurship and to the larger employment of the new graduates within their own business ventures.
Tópico(s): Entrepreneurship Studies and Influences
2007 - RELX Group (Netherlands) | SSRN Electronic Journal
Marina D. Rvović, Vera M. Divac, Ninko Radenković, Zorica Bugarčić,
An innovative route for intramolecular cyclization of pent- 4-en-1-ol has been delineated through a ring closing reaction with phenylselenyl halides, in good yield. Several catalysts (triethylamine, quinoline, 2,2ʹ-bipyridine, pyridine, CoCl 2 and SnCl 2 ) enable fast, facile and efficient cyclization.
Tópico(s): Chemical Synthesis and Reactions
2011 - De Gruyter | Zeitschrift für Naturforschung B
Ninko Kostovski, Elena Klisarovska,
Despite the advocates of the common EU identity, many people and scholars do believe that the EU will not ultimately prevent them from being French, Germans, Polish, and so on. It is almost impossible to avoid the recognition of the opposite phenomenon to the common identity, the growing ethnocentrism, particularly when EU is viewed from the perspective of the smaller countries and cultures. Many of them seem sincerely concerned about the prospects of the effective preservation of their cultural ...
Tópico(s): Corporate Governance and Law
2011 - RELX Group (Netherlands) | SSRN Electronic Journal
Marina Rvocic, Vera M. Divac, Ninko Radenković, Zorica Bugarčić,
Abstract Alternatively to PhSeCl, PhSeBr can be used as cyclization agent.
Tópico(s): Organic and Inorganic Chemical Reactions
2012 - Wiley | ChemInform
Zoran Sapurik, Ninko Kostovski, Elena Klisarovska,
Recent developments in the European Union in the field of economic policy show the need for redefinition of certain aspects of the common activities. The consequences of uncoordinated government spending and fiscal and monetary activities in the member states are evident. It led to large budget deficits in some member states which have caused a range of threats to their macroeconomic stability and to the overall macroeconomic stability of the entire Union. This requires urgent harmonization of the ...
Tópico(s): Global Financial Crisis and Policies
2012 - RELX Group (Netherlands) | SSRN Electronic Journal
Jadranka Mrsik, Ninko Kostovski,
Tópico(s): Financial Reporting and Valuation Research
2014 - RELX Group (Netherlands) | SSRN Electronic Journal
Ninko Kostovski, Н.М. Панкратова,
English Abstract: Exploration of the attitude of the Russians towards entrepreneurship. The importance and the influence of the cultural background, the religious sentiments, the role of the Church and the political system are commented in light of some recent research on the issue. We argue that the negative attitude, when present, is a result of the detrimental social impact of the post-Soviet era of aggressive economic restructuring and of the plethora of negative news in the relations with private ...
Tópico(s): Regional Socio-Economic Development Trends
2013 - RELX Group (Netherlands) | SSRN Electronic Journal
Ninko Kostovski, Milen Baltov,
Clusters, concentrations of businesses and research institutions, show high capacity for job creation, innovation and development. They can also, foster the access to the EU development funds. However, in the case of small business, their early tracing can be very difficult with top-down methods. The statistical activity code mapping, fairly appropriate for big industries, fails due to the apparent discrepancies between the registered and the actual activity of the small businesses. In addition, ...
Tópico(s): Regional Development and Policy
2013 - RELX Group (Netherlands) | SSRN Electronic Journal
Zoran Sapurik, Ninko Kostovski, Elena Klisarovska,
The Treaty on Stability, Coordination and Governance in the Economic and Monetary Union, known also as the Fiscal Stability Treaty or EU Fiscal Pact, entered into force on 1 January 2013, following the successful ratification by twelve of the sixteen signatory states. The Treaty introduced new rules in the Euro Zone and into the EU as a whole. Establishing strict requirements for budget deficit, it calls for strong fiscal discipline and for real fiscal austerity in many EU member states, which makes ...
Tópico(s): Economic and Fiscal Studies
2013 - RELX Group (Netherlands) | SSRN Electronic Journal
Mrsik Jadranka, Kostovski Ninko,
Abstract Incorporating environmental impact into financial reports is becoming standard practice in the 21 st Century. Investors are aware of the need for environmentally correct operations since failures in this domain lower the price of shares. However, in terms of regulation, in most of the countries, environmental reporting remains voluntary. Institutions dealing with development and promotion of the modern accounting and financial reporting standards encourage companies to concurrently report ...
Tópico(s): Sustainable Supply Chain Management
2015 - Oeconomica Timisiensis Foundation | Timisoara Journal of Economics and Business
Izet Zeqiri, Ninko Kostovski, Dana Gapkovska,
The role of the small and medium size enterprises as providers of employment and contributors to the well-being of the local communities is not questioned in the in the today’s globally changing society. As the small entrepreneurs usually start serving local markets, their close social environment is deciding influencer to their establishment, survivability and growth. Knowing that and having in mind that the unemployment is especially high among the young population in the larger urban communities, ...
Tópico(s): Entrepreneurship Studies and Influences
2017 - | Knowledge International Journal
Andrillene Laure Deutou Wondeu, Aline Okoko, Ghyslaine Bruna Djeunang Dongho, Christan Doll, Samuel Bahebegue, Ulrich Stéphane Mpeli Mpeli, Christian Chouamou Ninko, Carla Montesano, Nicolas Félicien Dologuele, Herman Parfait Awono-Ambene,
Case detection is essential for the management of human African trypanosomiasis (HAT), which is caused by Trypanosoma brucei gambiense. Prior to parasitological confirmation, routine screening using the card agglutination test for trypanosomiasis (CATT) is essential. Recently, individual rapid diagnostic tests (RDTs) for the serodiagnosis of HAT have been developed.The purpose of this study was to evaluate the contribution of SD Bioline HAT to the serological screening of human African trypanosomiasis ...
Tópico(s): Insect symbiosis and bacterial influences
2022 - PAGEPress (Italy) | Journal of Public Health in Africa