J Y Homma, Motohiro Matsuura, Shiro Kanegasaki, Yasuaki Kawakubo, Yasuhiko Kojima, Nobuyuki Shibukawa, Yoshio Kumazawa, Akihiro Yamamoto, Ken‐ichi Tanamoto, Tatsuji Yasuda, Masahiro Imoto, Hiroyuki Yoshimura, Shoichi Kusumoto, Tetsuo Shiba,
... Oxford Academic PubMed Google Scholar Yasuhiko KOJIMA, Yasuhiko KOJIMA *The Kitasato InstituteShirokane, Minato-ku, Tokyo 108 Search for other works by this author on: Oxford Academic PubMed Google Scholar Nobuyuki SHIBUKAWA, Nobuyuki SHIBUKAWA *The Kitasato InstituteShirokane, Minato-ku, ...
Tópico(s): Computational Drug Discovery Methods
1985 - Oxford University Press | The Journal of Biochemistry
Tadashi Nagamatsu, Noriyuki Kojima, Nobuyuki Kondo, Tomohisa Hattori, Ryoji Kojima, Mikio Ito, Yoshio Suzuki,
The suppressive effect of cyclosporin A (CyA) on the development of glomerulonephritis was evaluated in rats with either original- or crescentic-type anti-glomerular basement membrane (GBM) nephritis. CyA (2.5, 10 or 20 mg/kg) was given p.o. daily to original-type anti-GBM nephritic rats for 10 days from the day after the injection of anti-GBM serum. The development of the nephritis was dose-dependently suppressed by CyA before the production of specific antibody against rabbit γ-globulin (the heterologous ...
Tópico(s): Diabetes Treatment and Management
1992 - Japanese Pharmacological Society | The Japanese Journal of Pharmacology
Rikako Tanaka, Atsushi Okazawa, H. Konaka, Akito Sasaki, Norimichi Kojima, Nobuyuki Matsushita,
We successfully prepared and crystallographically characterized the first intermolecular charge-transfer (CT)-based vapochromic compound, (EV)(H3O)2[Fe(CN)6] (1-Wet, EV2+: 1,1'-diethyl-4,4'-bipyridine-1,1'-diium), an ethyl viologen-containing CT salt. 1-Wet, which is purple in color, is transformed into a brown powder (1-Dry) upon exposure to methanol vapor, drying over silica gel, or heating; 1-Dry returns to 1-Wet upon exposure to water vapor. These color changes are induced by hydration and dehydration, ...
Tópico(s): Free Radicals and Antioxidants
2018 - American Chemical Society | Inorganic Chemistry
Kuniharu Kojima, Nobuyuki Yoda, C. S. Marvel,
Abstract Basic catalysts in dimethylacetamide solution initiated the polymerization of maleimide to yield a low molecular weight polymer which has a copolymer structure. Approximately 75–85% of the recurring units are formed by hydrogen transfer and 15–25% by vinyl polymerization, as shown by hydrolysis, to yield aspartic acid on the one hand and ammonia and polymaleic acid on the other. Several maleimide derivatives have been prepared, but none has given a high molecular weight polymer by basic ...
Tópico(s): Synthetic Organic Chemistry Methods
1966 - Inderscience Publishers | Journal of Polymer Science Part A-1 Polymer Chemistry
Masanori Sugahara, M. Kojima, Nobuyuki Yoshikawa, T. Akeyoshi, Nobuo Haneji,
The intrinsic resistive transition of an oxide superconductor is found to follow the relation of a Kosterlitz-Thouless transition of binding-unbinding of vortex pairs.
Tópico(s): High-pressure geophysics and materials
1987 - Elsevier BV | Physics Letters A
Hiroshi Kitagawa, Norimichi Kojima, Nobuyuki Matsushita, Toshirō Ban, Ikuji Tsujikawa,
A new non-stoichiometric mixed-valence compound CsAu0.6Br2.6 has been prepared, and its powder X-ray diffraction profile, ESR spectra, and electrical conductivity determined. From its empirical formula the average valence of Au is + 2.67. Powder diffraction data indicate that the compound has a cubic perovskite structure [cubic lattice, space group Pm3m, a= 5.462(2)Å]. This means that the AuBr6 octahedra are crystallographically equivalent. ESR measurements show the existence of a +II formal oxidation ...
Tópico(s): Inorganic Chemistry and Materials
1991 - Royal Society of Chemistry | Journal of the Chemical Society. Dalton transactions
Naki Hiki, Hanzou Kurosaka, Yusuke Tatsutomi, Shouji Shimoyama, Eiichi Tsuji, Junichi Kojima, Nobuyuki Shimizu, Hitoshi ONO, Tatsuo Hirooka, Chiaki Noguchi, Ken‐ichi Mafune, Michio Kaminishi,
Background: Gl endoscopy without general anesthesia causes a hyperperistaltic state in the stomach, which frequently necessitates the use of antispasmodic agents, such as hyoscine-N-butylbromide, but these drugs have side effects. Peppermint oil is harmless and acts locally to inhibit Gl smooth muscle contraction. Methods: A randomized double-blind, double-dummy, controlled trial was conducted in 100 patients to compare the antispasmodic effects of hyoscine-N-butylbromide administered intramuscularly ...
Tópico(s): Gastrointestinal motility and disorders
2003 - Elsevier BV | Gastrointestinal Endoscopy
Keisuke Sasaki, Keigo Kurata, Nobuhiko Kojima, Nobuyuki Kurosawa, Shigenori Ohta, Nobuo Hanai, Shingo Tsuji, Tatsunari Nishi,
A cDNA encoding a G,-specific a-2,B-sialyltransferase (G,, synthase) was obtained from an expression cDNA library of human melanoma cell line WM266-4 by enrichment of Namalwa K J " 1 cells highly expressing G,, using an anti-G,, antibody and a fluorescence-activated cell sorter.Selection of B-cell line Namalwa cells expressing transfected cDNh in the presence of anti-G,, monoclonal antibody K M 6 4 1 gave a cDNA (pAMo-GD3) encoding a protein with a type I1 transmembrane topology as found for mammalian ...
Tópico(s): Carbohydrate Chemistry and Synthesis
1994 - Elsevier BV | Journal of Biological Chemistry
Nobuhiko Kojima, Nobuyuki Kurosawa, Tatsunari Nishi, Nobuo Hanai, Shingo Tsuji,
The expression of a single glycosyltransferase, GD3 synthase, caused cholinergic differentiation with neurite sprouting. The cells that expressed GD3 were established from Neuro2a cells by transfection of a mammalian expression vector into which were carried a cDNA encoding GD3 synthase and the blasticidin-S-deaminase gene with a SV40 promoter, followed by selection with blasticidin-S-hydrochloride. The blasticidin-S-hydrochloride-resistant colonies derived from the cells transfected with the cDNA ...
Tópico(s): 14-3-3 protein interactions
1994 - Elsevier BV | Journal of Biological Chemistry
Kenji Kono, Chie Kojima, Nobuyuki Hayashi, Eiko Nishisaka, Katsuyuki Kiura, Shinobu Watarai, Atsushi Harada,
We have developed poly(amidoamine) (PAMAM) dendrimers that have poly(ethylene glycol) (PEG) grafts at all dendrimer chain ends. To obtain PEG-modified dendrimers with sites for conjugation of anticancer drugs for this study, we prepared PAMAM G4 dendrimers that have a glutamic acid (Glu) residue at every chain end of dendrimer; PEG chains were attached to amino groups of Glu residues. We then combined the anticancer drug adriamycin to side chains of the Glu residues using an amide bond, [PEG–Glu(ADR)- ...
Tópico(s): Advanced biosensing and bioanalysis techniques
2008 - Elsevier BV | Biomaterials
Shinnosuke Kamei, Yoshiyuki Kojima, Nobuyuki Nishimiya,
This study reports the synthesis of novel red-emitting Eu3+-activated amorphous alkaline earth silicate phosphors with high emission intensities. Eu3+-activated barium (strontium) silicate hydrate phosphors were synthesized using a liquid phase reaction and then heated at 850 °C for 0.5 h to form amorphous barium (strontium) silicate phosphors. These amorphous phosphors emitted in the red region following near-UV (395 nm) irradiation. The internal quantum efficiencies of the Eu3+-activated amorphous ...
Tópico(s): Solid-state spectroscopy and crystallography
2010 - Elsevier BV | Journal of Luminescence
Nobuhiko Kojima, Nobuyuki Matsushita,
M2[AuIX2][AuIIIX4] (M=K, Rb, Cs; X=Cl, Br, I) are perovskite-type gold mixed-valence complexes. In this review, we describe their structural P–T phase diagram, the pressure induced Au valence transition from the AuI, III state to the AuII one, which is coupled with a structural phase transition. The metallic cubic phase appearing under high pressure and high temperature can be obtained as a metastable phase even at ambient pressure and room temperature. In the pressure region below the Au valence ...
Tópico(s): Magnetism in coordination complexes
2000 - Elsevier BV | Coordination Chemistry Reviews
Suguru Fukahori, Kimio Asagiri, Shinji Ishii, Yoshiaki Tanaka, Shin-ichiro Kojima, Nobuyuki Saikusa, Yoshinori Koga, Motomu Yoshida, Daisuke Masui, Naoko Komatsuzaki, Yoshitaka Seki, Minoru Yagi,
Gastroesophageal reflux disease (GERD) in patients with neurological impairment (NI) has not been fully studied before and after fundoplication procedure because their characteristics such as generalized gastrointestinal dysmotility, non-acid reflux, and the proximal reflux due to feeding of enteral nutrition via a nasogastric tube prevent their GERD from being detected by 24 h pH monitoring. The aim of this study was to elucidate whether multichannel impedance–pH measurement (pH/MII) is able to detect ...
Tópico(s): Helicobacter pylori-related gastroenterology studies
2013 - Springer Science+Business Media | Pediatric Surgery International
Yasuko Yoshida, Naoya Kojima, Nobuyuki Kurosawa, Toshiro Hamamoto, Shuichi Tsuji,
A cDNA encoding a new α2,8-sialyltransferase (ST8Sia III), which exhibits activity toward the Siaα2,3Galβ1,4GlcNAc sequences of N-linked oligosaccharides, was cloned from mouse brain by means of the polymerase chain reaction-based approach. The predicted amino acid sequence of ST8Sia III showed 27.6 and 34.4% identity with those of so far cloned mouse α2,8-sialyltransferases, i.e. GD3 synthase (ST8Sia I) and STX (ST8Sia II), respectively. Transfection of the protein A-fused ST8Sia III gene into COS- ...
Tópico(s): Proteoglycans and glycosaminoglycans research
1995 - Elsevier BV | Journal of Biological Chemistry
Masami Kojima, Nobuyuki Takei, Tadahiro Numakawa, Yasuyuki Ishikawa, Shingo Suzuki, Tomoya Matsumoto, Ritsuko Katoh‐Semba, Hiroyuki Nawa, Hiroshi Hatanaka,
To visualize the release dynamics of the brain-derived neurotrophic factor (BDNF) involved in neural plasticity, we constructed a plasmid encoding green fluorescent protein (GFP) fused with BDNF. First, several biological studies confirmed that this fusion protein (BDNF-GFP) mimics the biological functions and the release kinetics of unfused (native) BDNF. Second, when BDNF-GFP was expressed in cultured hippocampal neurons, we observed that this protein formed striking clusters in the neurites of mature ...
Tópico(s): Neuroscience and Neural Engineering
2001 - Wiley | Journal of Neuroscience Research
Tadahiro Numakawa, Tomoya Matsumoto, Naoki Adachi, Daisaku Yokomaku, Masami Kojima, Nobuyuki Takei, H. Hatanaka,
Abstract We reported previously that BDNF induced glutamate release was dependent on intracellular Ca 2+ but not extracellular Ca 2+ in cerebellar neurons (Numakawa et al., 1999 ). It was revealed that the release was through a non‐exocytotic pathway (Takei et al., 1998 ; Numakawa et al., 1999 ). In the present study, we monitored the dynamics of intracellular Ca 2+ and Na + in cerebellar neurons, and investigated the possibility of reverse transport of glutamate mediated by BDNF. As reported, BDNF increased ...
Tópico(s): Neurogenesis and neuroplasticity mechanisms
2001 - Wiley | Journal of Neuroscience Research
Hong Liu, Naoya Kojima, Nobuyuki Kurosawa, Shuichi Tsuji,
It was reported recently by our group that the transfection of GD3 synthase cDNA into Neuro2a cells, a neuroblastoma cell line, caused cell differentiation with neurite sprouting (Kojima et al, 1994; J. Biol Chem., 269, 30451–30456). To further explore this phenomenon in detail, we applied tet-racycline-regulated system to control the expression of GD3 synthase cDNA in Neuro2a cells. Under this system, the process of Neuro2a cell differentiation was rather slow, about 3 weeks of cell culturing in ...
Tópico(s): Virus-based gene therapy research
1997 - Oxford University Press | Glycobiology
Akira Ohara, Seiji Kojima, Nobuyuki Hamajima, Masahiro Tsuchida, Shinsaku Imashuku, Shigeru Ohta, Hideki Sasaki, Jun Okamura, Kanji Sugita, Hisato Kigasawa, Yukio Kiriyama, J Akatsuka, Ichiro Tsukimoto,
Abstract The improved outcome of acquired aplastic anemia (AA) has revealed later complications, such as myelodysplastic syndrome (MDS) and acute myelogenous leukemia (AML). We retrospectively analyzed 167 children with severe acquired AA. Eleven of 50 children treated with cyclosporin (CSA) and recombinant human granulocyte colony-stimulating factor (rhG-CSF ) developed MDS/AML; 8 of these were within 36 months of the diagnosis of AA, much earlier than previous reports. Six of the 11 children received ...
Tópico(s): Neutropenia and Cancer Infections
1997 - Elsevier BV | Blood
Yuzuru Ikehara, Nobuhiko Kojima, Nobuyuki Kurosawa, Takashi Kudo, Mari Kono, Shoko Nishihara, S. Issiki, K Morozumi, Steven H. Itzkowitz, T Tsuda, Shin‐Ichiro Nishimura, Shingo Tsuji, Hisashi Narimatsu,
The sialyl-Tn (sTn) antigen is a well known cancer-associated antigen, the expression of which is related to the prognosis of cancer patients. We aimed to isolate a human gene encoding an N-acetylgalactosamine α2,6-sialyltransferase which synthesizes sTn antigen, and to characterize the enzyme. Degenerate primers encoding sialyl motifs were used for the polymerase chain reaction to amplify complementary DNAs prepared from RNAs of human pyloric mucosae with intestinal metaplasia, which abundantly ...
Tópico(s): Monoclonal and Polyclonal Antibodies Research
1999 - Oxford University Press | Glycobiology
Kosuke Sugawa, Natsumi Tsunenari, Hideyuki Takeda, Saki Fujiwara, Tsuyoshi Akiyama, Jotaro Honda, Shuto Igari, Wataru Inoue, Kyo Tokuda, Naoto Takeshima, Yasuhiro Watanuki, Satoshi Tsukahara, Kouichi Takase, Tetsuo Umegaki, Yoshiyuki Kojima, Nobuyuki Nishimiya, Nobuko Fukuda, Yasuyuki Kusaka, Hirobumi Ushijima, Joe Otsuki,
We describe efficient visible- and near-infrared (vis/NIR) light-driven photocatalytic properties of hybrids of Cu2O and plasmonic Cu arrays. The Cu2O/Cu arrays were prepared simply by allowing a Cu half-shell array to stand in an oxygen atmosphere for 3 h, which was prepared by depositing Cu on two-dimensional colloidal crystals with a diameter of 543 or 224 nm. The localized surface plasmon resonances (LSPRs) of the arrays were strongly excited at 866 and 626 nm, respectively, at which the imaginary ...
Tópico(s): Advanced Photocatalysis Techniques
2017 - American Chemical Society | Langmuir
Shinichi Tamura, Joe Chiba, Asato Kojima, Nobuyuki Uchida,
Cloned T-cell lines that mediate delayed-type hypersensitivity (DTH) against soluble protein antigen, ovalbumin (OA), were established in (C57BL/6 X DBA/2)F1 mice and their properties were examined. They induced antigen-specific delayed-type footpad reactions, characterized histologically by a predominant mononuclear cell infiltration, when transferred intravenously into syngeneic mice. Morphologically, they were medium or large lymphoblasts with granules in the cytoplasm and expressed Lyt 1 cell surface ...
Tópico(s): Reproductive System and Pregnancy
1983 - Elsevier BV | Cellular Immunology
Akira Ohara, Seiji Kojima, Nobuyuki Hamajima, Masahiro Tsuchida, Shinsaku Imashuku, Shigeru Ohta, Hideki Sasaki, Jun Okamura, Kanji Sugita, Hisato Kigasawa, Yukio Kiriyama, J Akatsuka, Ichiro Tsukimoto,
The improved outcome of acquired aplastic anemia (AA) has revealed later complications, such as myelodysplastic syndrome (MDS) and acute myelogenous leukemia (AML). We retrospectively analyzed 167 children with severe acquired AA. Eleven of 50 children treated with cyclosporin (CSA) and recombinant human granulocyte colony-stimulating factor (rhG-CSF ) developed MDS/AML; 8 of these were within 36 months of the diagnosis of AA, much earlier than previous reports. Six of the 11 children received rhG-CSF ...
Tópico(s): Hematological disorders and diagnostics
1997 - Elsevier BV | Blood
Jing Jiang, Sadao Suzuki, Jin Xiang, Kiyonori Kuriki, Akihiro Hosono, Kazuyuki Arakawa, Jingwen Wang, Teruo Nagaya, Masayo Kojima, Nobuyuki Katsuda, Shinkan Tokudome,
To investigate associations between plasma carotenoids, α-tocopherol and retinol with colorectal adenomas risk, we measured concentrations in 224 asymptomatic colorectal adenoma cases and 230 population-based controls matched for age and sex. After adjustment for age, history of colorectal adenomas and cancers, BMI, smoking, drinking status, multivitamin consumption and plasma total cholesterol, the risk of colorectal adenomas in the highest quartile was approximately half of that of men in the ...
Tópico(s): Retinoids in leukemia and cellular processes
2005 - Elsevier BV | Cancer Letters
Hiroshi Kaneko, Yukitoshi Hosokawa, Noriko Kojima, Nobuyuki Gokon, Noriko Hasegawa, Masafumi Kitamura, Yutaka Tamaura,
Reactivities of three metal oxides (Fe2O3, TiO2 and MnO2) with Na2CO3, and of their reaction products with CO2, have been studied to enhance the O2-releasing step in the two-step water splitting by the MnFe2O4–Na2CO3 system. X-ray diffraction analysis and thermogravimetric measurements showed that the reaction of α-Fe2O3 with Na2CO3 (mole ratio=1:1) completed within 10 min at 1073 K to produce NaFeO2 (Fe2O3+Na2CO3→NaFeO2+CO2). Also, the regeneration of Fe2O3 and Na2CO3 proceeded readily by passing ...
Tópico(s): Industrial Gas Emission Control
2001 - Elsevier BV | Energy
Yuuki Koizumi, Yoshihito Tanaka, Takehiko Matsumura, Yoichi Kadoh, Haruko Miyoshi, Mitsuya Hongu, Kei Takedomi, Jun Kotera, Takashi Sasaki, Hiroyuki Taniguchi, Yumi Watanabe, Misae Takakuwa, Koki Kojima, Nobuyuki Baba, Itsuko Nakamura, Eiji Kawanishi,
We have developed a new class of PDE10A inhibitor, a pyrazolo[1,5-a]pyrimidine derivative MT-3014 (1). A previous compound introduced was deprioritized due to concerns for E/Z-isomerization and glutathione-adduct formation at the core stilbene structure. We discovered pyrazolo [1,5-a] pyrimidine as a new lead scaffold by structure-based drug design utilizing a co-crystal structure with PDE10A. The lead compound was optimized for in vitro activity, solubility, and selectivity against human ether-á- ...
Tópico(s): Receptor Mechanisms and Signaling
2019 - Elsevier BV | Bioorganic & Medicinal Chemistry
Hironori Fujii, Hirohisa Kojima, Nobuyuki Nakajima,
A control scheme is proposed for a rest-to-rest slew maneuver of a e exible space structure with constraints on the maximum value of the bending moment of the e exible structure. The e exible space structure treated is a rigid body equipped with a e exible appendage. The slew maneuver is a rest-to-rest maneuver with a constraint on the bending moment at the root of the e exible appendage, and a control scheme is studied to minimize the bending moment due to the structural vibration inevitably excited ...
Tópico(s): Fluid Dynamics Simulations and Interactions
2003 - American Institute of Aeronautics and Astronautics | Journal of Guidance Control and Dynamics
Enggah Kurniawan, Takayoshi Hara, Yessi Permana, Takashi Kojima, Nobuyuki Ichikuni, Shogo Shimazu,
Abstract Highly reducible CuO species were created by the calcination of a Cu-Al layered double hydroxide (CuAl LDH) at 1073 K under air. After this heat treatment, the original layered double hydroxide structure was completely transformed into CuO and CuAl2O4 phases. The synthesized calcined CuAl LDH (calc-CuAl LDH) promoted the catalytic hydrogenation of furfural (FALD) into furfuryl alcohol (FOL) with formic acid (FA) as a hydrogen donor. In the initial stage of the above catalytic reaction, the CuO ...
Tópico(s): Catalytic Processes in Materials Science
2021 - Oxford University Press | Bulletin of the Chemical Society of Japan
Saori Ogasawara, Masataka Ezaki, Ryusuke Ishida, Kuni Sueyoshi, Shunya Saito, Yuki Hiradate, Toru Kudo, Mitsuhiro Obara, Soichi Kojima, Nobuyuki Uozumi, Kentaro Tanemura, Toshihiko Hayakawa,
Summary Glutamine is a product of ammonium (NH 4 + ) assimilation catalyzed by glutamine synthetase (GS) and glutamate synthase (GOGAT). The growth of NH 4 + ‐preferring paddy rice ( Oryza sativa L.) depends on root NH 4 + assimilation and the subsequent root‐to‐shoot allocation of glutamine; however, little is known about the mechanism of glutamine storage in roots. Here, using transcriptome and reverse genetics analyses, we show that the rice amino acid transporter‐like 6 (OsATL6) protein exports glutamine to ...
Tópico(s): Plant Molecular Biology Research
2021 - Wiley | The Plant Journal
Naoya Kojima, Young‐Choon Lee, Toshiro Hamamoto, Nobuyuki Kurosawa, Shuichi Tsuji,
... 3GalNAc .alpha.2,3-Sialyltransferase from Mouse BrainNaoya Kojima, Young-Choon Lee, Toshiro Hamamoto, Nobuyuki Kurosawa, and Shuichi TsujiCite this: Biochemistry 1994, 33, ...
Tópico(s): Galectins and Cancer Biology
1994 - American Chemical Society | Biochemistry
Tetsuo Hatakeyama, Takatoshi Watanabe, Kazutoshi Kojima, Nobuyuki Sano, Kazunori Shiraishi, Mitsuhiro Kushibe, Seiji Imai, Takashi Shinohe, Takaya Suzuki, Tomoyuki Tanaka, Kazuo Arai,
Tópico(s): Electromagnetic Compatibility and Noise Suppression
2004 - Trans Tech Publications | Materials science forum