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... respond to treatment? Is it because of the nocebo effect? Roger Dobson reports Ask Great Ormond Street ...
2007 - Gale Group | TDA
Tessa Rooney, Louise Sharpe, Jemma Todd, Biya Tang, Ben Colagiuri,
The nocebo effect represents a growing concern in clinical settings. Nocebo effects occur when the treatment context generates negative ... not been an attempt to systematically quantify the nocebo effects across health outcomes. The purpose of the ... thus to systematically review and meta-analyze the nocebo literature to quantify the size of the nocebo effect across outcomes and examine which factors moderate the size of the nocebo effect, including process of induction, treatment type, or ... be included, studies had to include both a nocebo and control group/condition, which were compared to ...
Tópico(s): Pain Management and Placebo Effect
2023 - American Psychological Association | Health Psychology
Mia A. Thomaidou, Joseph S. Blythe, Kaya J. Peerdeman, Antoinette I. M. van Laarhoven, Myrthe M. E. Van Schothorst, Dieuwke S. Veldhuijzen, Andrea W.M. Evers,
ABSTRACT Objective In past decades, the field of nocebo research has focused on studying how sensory perception can be shaped by learning. Nocebo effects refer to aggravated sensory experiences or increased ... Gaining a comprehensive view of the magnitude of nocebo effects and contributing factors will help steer nocebo research toward fruitful directions for understanding complex sensory ... analysis of a total of 37 distinct experimental nocebo studies on healthy participants (all published in English ...
Tópico(s): Empathy and Medical Education
2023 - Lippincott Williams & Wilkins | Psychosomatic Medicine
Les effets placebo et nocebo sont des phénomènes psychobiologiques puissants qui sont influencés par les attentes du patient et le contexte dans lequel le traitement ... y compris la podiatrie. En podiatrie, l'effet nocebo peut être particulièrement pertinent en raison des symptômes ... aux problèmes de pieds. Pour prévenir l'effet nocebo et améliorer le résultat thérapeutique en podiatrie, il ... des mécanismes neurophysiologiques derrière les effets placebo et nocebo sera cruciale pour faire avancer le domaine de ...
Tópico(s): Empathy and Medical Education
2023 - Elsevier BV | Douleurs Évaluation - Diagnostic - Traitement
... to their clinical notes-the potential to increase 'nocebo effects'. A growing body of research shows that nocebo effects arise by engaging perceptual and cognitive processes ... context of care can increase the risk of nocebo effects. Connecting research into the nocebo effect with open notes provides preliminary support for ... notes might be a forum for facilitating unwanted nocebo effects. Furthermore, current findings indicate that we might expect to see systematic differences in how nocebo effects are experienced among different patient populations. The ...
Tópico(s): Healthcare cost, quality, practices
2022 - BMJ | Journal of Medical Ethics
Yu Zhang, Yingying Xu, Shuping Liu, Jingjing Liang, Shanghua Fan, Man Ding, Juan Wang, Zheman Xiao,
The nature and magnitude of nocebo responses in primary headache disorders are still unknown. To assess the distribution and possible predictors of nocebo responses in primary headache treatments, databases, including PubMed, ... trials of pharmacologic treatments of primary headaches. The nocebo responses were calculated using a random effects meta- ... associations of study design and demographic characteristics with nocebo responses. A total of 178 randomized controlled trials ... inclusion criteria were included. Prophylactic treatments elicited stronger nocebo responses than acute treatments. The majority of nocebo ...
Tópico(s): Complementary and Alternative Medicine Studies
2022 - Wiley | The Journal of Clinical Pharmacology
K. J. Arrow, Laura L. Burgoyne, Allan M Cyna,
Summary Nocebo refers to non‐pharmacological adverse effects of an intervention. Well‐intended procedural warnings frequently function as a nocebo. Both nocebo and placebo are integral to the generation of ‘ ... the neuroscience literature has repeatedly demonstrated that the nocebo effect is mediated by discrete neurobiological mechanisms and ... biological mechanism has been found to explain the nocebo effect, nocebo hyperalgesia is thought to initiate from the dorsal ... in the perception of affective pain evoked by nocebo words. Research has also explored neurotransmitters which mediate ...
Tópico(s): Empathy and Medical Education
2022 - Wiley | Anaesthesia
Yvonne Nestoriuc, Yiqi Pan, Timm Kinitz, Ella Weik, Meike C. Shedden‐Mora,
... Current information practices might rather harm by inducing nocebo effects. Objective: To investigate whether informing about the nocebo effect using a short information sheet affects patients’ ... either a one-page written information about the nocebo effect or a control text about the history ... 42.3%). Three participants (6.0%) of the nocebo group reported previous knowledge of the nocebo effect. After the experimental manipulation, participants in the nocebo group reported a reduced desire for receiving full ...
Tópico(s): Treatment of Major Depression
2021 - Frontiers Media | Frontiers in Psychiatry
Áron Horváth, Ferenc Köteles, Attila Szabó,
Directionally opposite to placebo effects are the nocebo effects that negatively impact people's thoughts, feelings, and actions. An important but scarcely studied aspect of everyday functioning is motor performance, in which nocebo effects might impair athletic skills and the much- ... of this literature review is to unveil the nocebo effects on motor performance. Searched databases were PubMed, ... bias. Of the 23 studies, 14 found a nocebo effect on motor performance, equivocal results emerged from ... using a between-subjects design have reported a nocebo effect. The mean effect size was 0.60, ...
Tópico(s): Acupuncture Treatment Research Studies
2021 - Wiley | Scandinavian Journal of Psychology
Alanna Mao, Kirsten Barnes, Louise Sharpe, Andrew L. Geers, Suzanne G. Helfer, Kate Faasse, Ben Colagiuri,
... can contribute directly to their occurrence via the nocebo effect. This creates a challenge for clinicians and ... has been proposed as a method for reducing nocebo side effects whilst maintaining the principles of informed ... mixed.To test whether positive attribute framing reduces nocebo side effects relative to negative framing, general warning, ... no warning overall, confirming that warnings can induce nocebo side effects. Importantly, however, positive framing reduced cybersickness ... findings suggest that positive framing not only reduces nocebo side effects relative to negative framing and general ...
Tópico(s): Psychosomatic Disorders and Their Treatments
2021 - Oxford University Press | Annals of Behavioral Medicine
Mia A. Thomaidou, Joseph S. Blythe, Simon J. Houtman, Dieuwke S. Veldhuijzen, Antoinette I. M. van Laarhoven, Andrea W.M. Evers,
... This study aimed to identify electrophysiological correlates of nocebo-augmented pain. Nocebo hyperalgesia (i.e., increases in perceived pain resulting ... terms of its neurophysiological underpinnings. In this study, nocebo hyperalgesia was induced in 36 healthy participants through ... participants received baseline high thermal pain stimulations. During nocebo acquisition, participants learned to associate an inert gel ... stimuli were accompanied by moderate pain, to measure nocebo responses to the inert gel. Pre- to post- ...
Tópico(s): Psychosomatic Disorders and Their Treatments
2021 - Nature Portfolio | Scientific Reports
Andrew L. Geers, Kelly S. Clemens, Kate Faasse, Ben Colagiuri, Rebecca Webster, Lene Vase, Mette Sieg, E Chan Jason, Luana Colloca,
... hesitancy might be influenced by psychosocial factors, particularly nocebo effects. Nocebo effects occur when negative expectations and related factors ( ... depressive symptoms) trigger or exacerbate negative symptoms [7]. Nocebo effects go beyond response bias and have neurobiological ... and headache, are known to be sensitive to nocebo effects. Thus, psychosocial factors, such as expectations, emotions, ... vaccine trials [8], suggesting non-pharmacological causes. Therefore, nocebo effects may worsen side effects related to the ...
Tópico(s): COVID-19 and Mental Health
2021 - Karger Publishers | Psychotherapy and Psychosomatics
Yu Shi, Shao-Ye Cui, Yanyan Zeng, Shimin Huang, Guiyuan Cai, Jian‐Ming Yang, Wen Wu,
Background and Objective: Placebo and nocebo responses are widely observed. Herein, we investigated the nocebo hyperalgesia and placebo analgesia responses in brain network in acute lower back ... during a placebo intervention and once during a nocebo intervention, pseudo-randomly ordered. fMRI scans were performed ... from baseline (pain status) for both placebo and nocebo interventions, as well as between placebo and nocebo interventions. In placebo network, we found a negative ... as the supplementary motor area (SMA). In the nocebo network, we also found a positive lagged-temporal ...
Tópico(s): Acupuncture Treatment Research Studies
2021 - Frontiers Media | Frontiers in Behavioral Neuroscience
Lewis Crawford, Emily P. Mills, Theo Hanson, Paul M. Macey, Rebecca Glarin, Vaughan G. Macefield, Kevin A. Keay, Luke A. Henderson,
... in the modulatory phenomena of placebo analgesia and nocebo hyperalgesia remain to be directly addressed. This study ... present during the generation of placebo analgesia and nocebo hyperalgesia in healthy human participants ( N = 25, 12 ... two inert creams labeled lidocaine (placebo) and capsaicin (nocebo) were acting to modulate their pain relative to ... Pain intensity ratings were collected and placebo and nocebo responses determined. Brainstem-specific fMRI analysis revealed altered ... medulla (RVM) pathway when both greater placebo and nocebo effects were observed. Additionally, we found that placebo ...
Tópico(s): Acupuncture Treatment Research Studies
2021 - Society for Neuroscience | Journal of Neuroscience
Matthew J. Coleshill, Louise Sharpe, Ben Colagiuri,
Placebo and nocebo effects in pain are well documented. One leading explanation is that instructions indicating that pain will either increase ... was to test the hypothesis that attention mediates nocebo hyperalgesia. This was done by measuring attentional bias ... dot-probe task both before and after a nocebo manipulation.Ninety-six healthy volunteers were randomized to ... placebo instructions, (2) an inert nasal spray with nocebo instructions, or (3) no treatment. Participants completed measures ... before and after randomization.Results showed that the nocebo instructions induced expectations for increased pain and resulted ...
Tópico(s): Empathy and Medical Education
2021 - Wolters Kluwer | PAIN Reports
Ben Colagiuri, Jeong In Park, Kirsten Barnes, Louise Sharpe, Robert A. Boakes, Luana Colloca, Evan J. Livesey,
Nocebo hyperalgesia is a pervasive problem that significantly adds to the burden of pain. Conditioning is a key mechanism of nocebo hyperalgesia and recent evidence indicates that, once established, nocebo hyperalgesia is resistant to extinction. This means that ... and pre-exposure (Experiment 2) – could inhibit conditioned nocebo hyperalgesia. Overshadowing involves introducing additional cues during conditioning ... compete with and overshadow learning about the target nocebo cue. Pre-exposure involves pre-exposing the target ...
Tópico(s): Pediatric Pain Management Techniques
2021 - Elsevier BV | Journal of Pain
Mia A. Thomaidou, Kaya J. Peerdeman, Melissa I. Koppeschaar, Andrea W.M. Evers, Dieuwke S. Veldhuijzen,
... review summarizes and interprets the neurobiological correlates of nocebo hyperalgesia in healthy humans. Nocebo hyperalgesia refers to increased pain sensitivity resulting from ... pain in healthy and patient populations. The young nocebo field has employed various methods to unravel the ... PsychInfo databases were searched to identify studies examining nocebo hyperalgesia while utilizing neurobiological measures. The final selection ... biochemicals such as cortisol plays a role in nocebo hyperalgesia but showed an involvement of the cyclooxygenase- ...
Tópico(s): Neuroscience, Education and Cognitive Function
2021 - Frontiers Media | Frontiers in Neuroscience
Andrew L. Geers, Kate Faasse, Darwin A. Guevarra, Kelly S. Clemens, Suzanne G. Helfer, Ben Colagiuri,
... nuisance variance in clinical trials, placebo effects and nocebo effects are now widely recognized as important and ... empirical data linking affective states to placebo and nocebo effects. To organize this disparate literature, three questions ... existing state and trait affect modulate placebo and nocebo effects? (2) Does administering placebo and nocebo treatments change affective states, and if so, does the resulting affect causally influence placebo and nocebo effects? Finally, (3) Can placebo treatments be successfully ...
Tópico(s): Empathy and Medical Education
2020 - Wiley | Social and Personality Psychology Compass
Dimos D. Mitsikostas, Charlotte Blease, Elisa Carlino, Luana Colloca, Andrew L. Geers, Jeremy Howick, Andrea W.M. Evers, Magne Arve Flaten, John M. Kelley, Irving Kirsch, Regine Klinger, Antoinette MaassenVanDenBrink, Daniel E. Moerman, Petros P. Sfikakis, Lene Vase, Tor D. Wager, Fabrizio Benedetti,
... the current terminology related to the placebo and nocebo phenomena observed in clinical trials and practice, nor ... clinical trials: [1] to distinguish the placebo or nocebo response from the placebo or nocebo effect ; and [2] for any favorable outcome observed ... unfavorable outcome recorded after placebo administration, the term “ nocebo response ” should be used (12 out of 17 panelists agreed, 70.6% agreement). The placebo or nocebo responses are attributed to a set of factors ... with idiosyncratic ones, in which the placebo or nocebo effects are attributed to idiosyncratic, or nonspecific mechanisms, ...
Tópico(s): Neurology and Historical Studies
2020 - Springer Nature | The Journal of Headache and Pain
Mia A. Thomaidou, Dieuwke S. Veldhuijzen, Ann Meulders, Andrea W.M. Evers,
Abstract Nocebo hyperalgesia refers to increases in perceived pain that putatively result from negative expectations regarding a nocebo stimulus (eg, an inert treatment, compared with no ... cognitive-emotional factors contributing to the origins of nocebo effects are poorly understood. We aimed to test ... related fear on the acquisition and extinction of nocebo hyperalgesia in healthy participants (N = 72). Acquisition and extinction of nocebo hyperalgesia were compared between a group receiving standard ...
Tópico(s): Psychological Treatments and Assessments
2020 - Lippincott Williams & Wilkins | Pain
Giacomo Rossettini, Tommaso Geri, Alvisa Palese, Chiara Marzaro, Mattia Mirandola, Luana Colloca, Mirta Fiorio, Andrea Turolla, Mattia Manoni, Marco Testa,
... OMTs) regarding context factors (CFs) capable of triggering nocebo effects during the treatment and how this knowledge ... questions); (b) the relation between different CFs and nocebo-related effects (2 questions); and (c) the knowledge of participants about nocebo-related effects and how they managed them in ... of 31.0 ± 7.1 years. OMTs defined nocebo-related effects as the psychosocial context effects around ... know that their clinical practice is pervaded by nocebo-related effects (42.5%), triggered by CFs. Participants ...
Tópico(s): Empathy and Medical Education
2020 - Frontiers Media | Frontiers in Psychology
Andrea W.M. Evers, Luana Colloca, Charlotte Blease, Jens Gaab, Karin B. Jensen, Lauren Y. Atlas, Chris Beedie, Fabrizio Benedetti, Ulrike Bingel, Christian Büchel, Jet Bussemaker, Ben Colagiuri, Alia J. Crum, Damien G. Finniss, Andrew L. Geers, Jeremy Howick, Regine Klinger, Stefanie H. Meeuwis, Karin Meißner, Vitaly Napadow, Keith J. Petrie, Winfried Rief, Ionica Smeets, Tor D. Wager, Vishvarani Wanigasekera, Lene Vase, John M. Kelley, Irving Kirsch,
... Clinical and laboratory studies demonstrate that placebo and nocebo effects influence various symptoms and conditions after the ... on how to inform patients about placebo and nocebo effects in clinical practice and train clinicians how ... Based on previous clinical recommendations concerning placebo and nocebo effects, a 3-step, invitation-only Delphi study ... patients about placebo effects, (2) informing patients about nocebo effects, and (3) training clinicians how to communicate ... consensus that communicating general information about placebo and nocebo effects to patients (e.g., explaining their role ...
Tópico(s): Psychological Treatments and Assessments
2020 - Karger Publishers | Psychotherapy and Psychosomatics
Mia A. Thomaidou, Dieuwke S. Veldhuijzen, Kaya J. Peerdeman, Naomi Zoë Sifra Wiebing, Joseph S. Blythe, Andrea Walbruga Maria Evers,
Abstract Nocebo hyperalgesia is a clinically relevant phenomenon and may be formed as a result of associative learning, implemented ... This study explored for the first time distinct nocebo conditioning methods and their consequences for nocebo attenuation methods. Healthy participants (N = 140) were recruited and randomized to the following nocebo hyperalgesia induction groups: conditioning with continuous reinforcement (CRF), ... participants experienced increased thermal pain in 100% of nocebo trials in the CRF groups, while in only ...
Tópico(s): Acupuncture Treatment Research Studies
2020 - Lippincott Williams & Wilkins | Pain
Giacomo Rossettini, Eleonora Maria Camerone, Elisa Carlino, Fabrizio Benedetti, Marco Testa,
Placebo and nocebo effects embody psychoneurobiological phenomena where behavioural, neurophysiological, perceptive and cognitive changes occur during the therapeutic encounter in the ... are produced by a positive healthcare context; while nocebo effects are consequences of negative healthcare context. Historically, placebo, nocebo and context-related effects were considered as confounding ... using the healthcare context to trigger placebo and nocebo effects is currently limited and heterogeneous among physiotherapists, ...
Tópico(s): Psychosomatic Disorders and Their Treatments
2020 - BioMed Central | Archives of Physiotherapy
Fabian Wolters, Kaya J. Peerdeman, Andrea W.M. Evers,
Placebo and nocebo effects are, respectively, the helpful and harmful treatment effects that do not arise from active treatment components. These ... other somatic symptoms. This review investigates placebo and nocebo effects in four other highly prevalent symptoms: dyspnea, ... learning mechanisms (verbal suggestions, conditioning) in placebo and nocebo effects on various outcomes (self-reported, behavioral, and ... effective than suggestion alone for evoking placebo and nocebo effects. However, conditioning appears more and verbal suggestions ...
Tópico(s): Empathy and Medical Education
2019 - Frontiers Media | Frontiers in Psychiatry
Elisabeth Vögtle, Birgit Kröner‐Herwig, Antonia Barke,
Nocebo hyperalgesia is an increase in pain through the expectation of such an increase as a consequence of a sham treatment. Nocebo hyperalgesia can be induced by observation of a ... such as facial pain expressions, can also induce nocebo responses.Eighty female participants (age: 22.4 y± ... either modeled increased pressure pain upon ointment application (nocebo condition) or showed a neutral facial expression throughout ( ... A 2×2 analysis of variance with condition (nocebo; control) as a between-subjects factor and ointment ...
Tópico(s): Musculoskeletal pain and rehabilitation
2019 - Lippincott Williams & Wilkins | Clinical Journal of Pain
... can influence health outcomes through the placebo and nocebo effects in pain medicine. Namely, the 5 articles ... placebo effects in nursing,15 strategies to minimize nocebo effects,12 and relevance of placebo effects for ... snapshot of the clinical relevance of placebo and nocebo effects and, most importantly, how health practitioners might ... perception of health pain outcomes through placebo and nocebo effects.4 However, it remained unknown how the ... measured the occurrence and persistence of placebo and nocebo effects when an operant avoidance learning task was ...
Tópico(s): Pediatric Pain Management Techniques
2019 - Wolters Kluwer | PAIN Reports
Meriem Manaï, Henriët van Middendorp, Dieuwke S. Veldhuijzen, T. Huizinga, Andrea W.M. Evers,
Nocebo effects, such as side effects due to negative expectations regarding the pain treatment, are a concern ... factors that contribute to the susceptibility to the nocebo effect on pain and related outcomes and suggests strategies that can prevent, minimize, or extinguish nocebo effects in clinical settings. Nocebo effects are the result of psychological (eg, conditioning, ... to various recommendations and strategies to alter the nocebo effect in order to optimize pain treatments, such ... experimental studies provides a better understanding of the nocebo effect and possible factors that modulate its strength ...
Tópico(s): Pain Mechanisms and Treatments
2019 - Wolters Kluwer | PAIN Reports
The term nocebo effect refers to the harmful outcomes that result from people’s negative beliefs, anticipations, or experiences related to ... placebo that is supposed to imitate it. The nocebo effect is always unwanted and may distort estimates ... of therapy or withdrawal from a trial. The nocebo effect may be unintentionally evoked by the explanations ... lack of blinding, may introduce bias from the nocebo effect. Unlike the placebo effect, which is usually ... outcomes and controlled for in clinical trials, the nocebo effect is under-recognised by clinical researchers and ...
Tópico(s): Neuroscience, Education and Cognitive Function
2019 - Faculty of 1000 | F1000Research
Aleksandrina Skvortsova, Dieuwke S. Veldhuijzen, Henriët van Middendorp, Luana Colloca, Andrea W.M. Evers,
... investigated whether oxytocin can increase placebo analgesia, decrease nocebo hyperalgesia, and influence extinction processes of both. Eighty ... to a placebo control group. Placebo analgesia and nocebo hyperalgesia were induced by a conditioning procedure in ... conditioning procedure successfully elicited significant placebo analgesia and nocebo hyperalgesia responses (P < .001). Furthermore, extinction was observed (P < .001), although placebo and nocebo responses did not return to baseline and remained significant. Oxytocin did not influence placebo analgesia or nocebo hyperalgesia and had no effect on extinction. This ...
Tópico(s): Empathy and Medical Education
2019 - Elsevier BV | Journal of Pain