... mammalian nociceptors12 October 2017 | eLife, Vol. 6Specialized Mechanosensory Nociceptors Mediating Rapid Responses to Hair PullNeuron, Vol. 95, ... Postnatal Loss of Heat Sensitivity Among Cutaneous Myelinated Nociceptors in Swiss–Webster MiceYi Ye, and C. Jeffery ... Vol. 103, No. 3Cannabinoid Modulation of Cutaneous Aδ Nociceptors During InflammationCarl Potenzieri, Thaddeus S. Brink, Cholawat Pacharinsak, ... 98, No. 2Heat Sensitization in Skin and Muscle Nociceptors Expressing Distinct Combinations of TRPV1 and TRPV2 ProteinK. ...
Tópico(s): Neuroscience and Neural Engineering
1969 - American Physiological Society | Journal of Neurophysiology
James N. Campbell, Richard A. Meyer, R. H. LaMotte,
... FiguresReferencesRelatedInformation Cited ByHeat Sensitization in Skin and Muscle Nociceptors Expressing Distinct Combinations of TRPV1 and TRPV2 ProteinK. ... of Neurophysiology, Vol. 97, No. 4Morphine Directly Inhibits Nociceptors in Inflamed SkinHeather N. Wenk*, Jill-Desiree Brederson*, ... No. 2Response of Cutaneous A- and C-Fiber Nociceptors in the Monkey to Controlled-Force StimuliR. M. ... 83, No. 4Mechanical and Heat Sensitization of Cutaneous Nociceptors After Peripheral Inflammation in The RatDavid Andrew, and ...
Tópico(s): Pain Mechanisms and Treatments
1979 - American Physiological Society | Journal of Neurophysiology
James N. Campbell, Richard A. Meyer,
... to C fiber thermonociceptorsNeuroImage, Vol. 146Morphine Directly Inhibits Nociceptors in Inflamed SkinHeather N. Wenk*, Jill-Desiree Brederson*, ... Vol. 21, No. 3-4Two Types of C Nociceptors in Human Skin and Their Behavior in Areas ... Mediators and by Mild Burn in Canine Visceral Nociceptors In VitroHisashi Koda, and Kazue Mizumura1 April 2002 | ... No. 2Response of Cutaneous A- and C-Fiber Nociceptors in the Monkey to Controlled-Force StimuliR. M. ... 858, No. 1Mechanical and Heat Sensitization of Cutaneous Nociceptors After Peripheral Inflammation in The RatDavid Andrew, and ...
Tópico(s): Photoreceptor and optogenetics research
1983 - American Physiological Society | Journal of Neurophysiology
Hervé A. Martin, A. I. Basbaum, E J Goetzl, Jon D. Levine,
... 5-lipoxygenase pathway of arachidonic acid metabolism, sensitizes nociceptors to mechanical stimuli. The present study examined whether ... induces a heat sensitization of cutaneous C-fiber nociceptors. The C-fiber nociceptors studied had von Frey hair thresholds greater than ... acetic acid. They were classified as C-polymodal nociceptors (2, 28). Those that were activated by intense ... unresponsive to acid, were classified as C-mechanoheat nociceptors (27). 2. Ninety-four percent of C-polymodal nociceptors and 60% of C-mechanoheat nociceptors were sensitized ...
Tópico(s): Advancements in Transdermal Drug Delivery
1988 - American Physiological Society | Journal of Neurophysiology
... dorsal root ganglia (DRG) show that most (⬎70%) nociceptors are polymodal: they can be activated by multiple ... is unlikely at- tributable to modality-specific primary nociceptor subsets. Rather, it is believed that modality discrimination occurs by the decoding of nociceptor inputs in higher order spinal cord or brain ... is that targeted ablation of any single specific nociceptor subpopulation should cause deficits in behav- ioral responses ... marker either in a homogeneous population of polymodal nociceptors or in multiple modality-specific subpopula- tions. Modality ...
Tópico(s): Pain Mechanisms and Treatments
2009 - National Academy of Sciences | Proceedings of the National Academy of Sciences
Robert H. LaMotte, Lars Lundberg, H. E. Torebjörk,
... the receptive fields of 14 C mechanoheat (polymodal) nociceptor units in awake humans. The nociceptor discharges were recorded using microelectrodes inserted into the ... 4 mm outside, the receptive fields of C nociceptor units evoked discharges. The magnitude of pain and ... next 1‐3 min, which indicates that these nociceptors contribute to the magnitude and duration of pain ... injection. 3. Reduced or abolished excitability in C nociceptors after capsaicin injection within the receptive fields correlated ...
Tópico(s): Plant and Biological Electrophysiology Studies
1992 - Wiley | The Journal of Physiology
Produção Nacional
Revisado por pares
Daniela Sachs, Fernando Q. Cunha, Stephen Poole, Sérgio Henrique Ferreira,
... days cause the development of a persistent mechanical nociceptor hypersensitivity state lasting more than 30 days. Considering ... TNF-α) are able to induce persistent mechanical nociceptor hypersensitivity. Daily i.pl. administration of TNF-α, ... 8 for 18 days led to persistent mechanical nociceptor hypersensitivity, which lasted at least 30 days after ... with atenolol, prevented the induction of persistent mechanical nociceptor hypersensitivity. The co-treatment of the animals with ... with indomethacin, prevented the induction of persistent mechanical nociceptor hypersensitivity. The daily co-treatment of TNF-α ...
Tópico(s): Acupuncture Treatment Research Studies
2002 - Lippincott Williams & Wilkins | Pain
Seth C. Silbert, Daniel Beacham, Edwin W. McCleskey,
... the mu-opioid receptor (MOR) gene in primary nociceptors (pain-sensing neurons) might contribute to this aspect ... measured opioid inhibition of Ca channels on identified nociceptors and low-threshold mechanosensors (non-nociceptors) isolated from rats. Negligibly few non-nociceptors express MOR mRNA, thereby rendering nonpain sensations insensitive to opioids. Nearly half of nociceptors of all size classes also fail to express ... to respond to opioids. Among the opioid-responsive nociceptors, a gene dose-response relationship exists such that ...
Tópico(s): Ion channel regulation and function
2003 - Society for Neuroscience | Journal of Neuroscience
Kazuo Toda, Jorge L. Zeredo, Rie Fujiyama, Yukio Okada, Kumiko Oi, Yoshihiko Hayashi, Fajar Hamonangan Nasution,
Recent studies have indicated that nociceptors can be classified into various types according to their physiological properties. These studies have clarified that the frequency distribution of various nociceptor types is different among body sites and animal ... investigated the physiological properties of rat’s periodontal nociceptors in an in vitro jaw-nerve preparation. Responses ... in the inferior alveolar nerve. To determine the nociceptor type, calibrated von Frey filaments, heat, and bradykinin ( ...
Tópico(s): Hormonal and reproductive studies
2003 - Elsevier BV | Brain Research Bulletin
Christopher Voscopoulos, Mark J. Lema,
... to be activated. It is the activation of nociceptors in the periphery, and their ongoing activation, through ... of the transition to the chronic pain state. Nociceptors are free nerve endings, with no extracellular matrix ... Kavookjian A Kumazawa T Light A Mizumura K Nociceptor structural specialization in canine and rodent testicular ‘free’ ... 463: 197-211Crossref PubMed Scopus (0) Google Scholar Nociceptors are present in skin, muscle, joints, and viscera, ... 5Gold M Gebhart G Peripheral pain mechanisms and nociceptor sensitization.in: Fishman S Ballantyne JC Rathmell JP ...
Tópico(s): Pain Management and Opioid Use
2010 - Elsevier BV | British Journal of Anaesthesia
F. Ru, Lenka Surdenikova, Mariana Brozmanová, Marián Kollárik,
... addressed the hypothesis that adenosine selectively activates esophageal nociceptors. Whole cell perforated patch-clamp recordings and single- ... crest-derived (spinal DRG and vagal jugular) esophageal nociceptors expressed predominantly the adenosine A 1 receptor while the placodes-derived vagal nodose nociceptors expressed the adenosine A 1 and/or A ... nerve terminals. Furthermore, the neural crest-derived jugular nociceptors were activated by the selective A 1 receptor agonist CCPA, and the placodes-derived nodose nociceptors were activated by CCPA and/or the selective ...
Tópico(s): Ion channel regulation and function
2010 - American Physiological Society | AJP Gastrointestinal and Liver Physiology
Omar Abdel Samad, Yang Liu, Fu‐Chia Yang, Ina Krämer, Silvia Arber, Qiufu Ma,
... transcription factor Runx1 is initially expressed in most nociceptors and controls sensory neuron phenotypes necessary for inflammatory ... ion channels and receptors is distributed into two nociceptor populations that are distinguished by persistent or transient ... stages leads to preferential impairment of Runx1-persistent nociceptors and a selective defect in inflammatory pain. Conversely, constitutive Runx1 expression in Runx1-transient nociceptors leads to an impairment of Runx1-transient nociceptors ...
Tópico(s): Ion Channels and Receptors
2010 - SAGE Publishing | Molecular Pain
Judith P. Golden, Masato Hoshi, Mohammed A. Nassar, Hideki Enomoto, John N. Wood, Jeffrey Milbrandt, Robert W. Gereau, Eugene M. Johnson, Sanjay Jain,
Small unmyelinated sensory neurons classified as nociceptors are divided into two subpopulations based on phenotypic differences, including expression of neurotrophic factor receptors. Approximately half of unmyelinated nociceptors express the NGF receptor TrkA, and half express ... NGF/TrkA signaling in the TrkA population of nociceptors has been extensively studied, and NGF/TrkA signaling ... the physiological function of GFL/Ret signaling in nociceptors. However, perinatal lethality of Ret -null mice has ...
Tópico(s): Ion Channels and Receptors
2010 - Society for Neuroscience | Journal of Neuroscience
Elizabeth K. Joseph, J.D. Levine,
... model for the contribution of neuroplastic changes in nociceptors to the transition from acute to chronic pain. ... In this study we evaluated the population of nociceptors involved in priming, by lesioning isolectin B4-positive (IB4(+)) nociceptors with intrathecal administration of a selective neurotoxin, IB4-saporin. To confirm that the remaining, TrkA(+)/IB4(-), nociceptors are still functional, we evaluated if nerve growth ... acute mechanical hyperalgesia, priming is restricted to IB4(+)-nociceptors, including those that are TrkA(+). While PKCepsilon activation ...
Tópico(s): Pharmacological Effects of Natural Compounds
2010 - Elsevier BV | Neuroscience
... imperative to know about it. This is what nociceptors do—these primary sensory neurons are specialized to ... experience of an intensely unpleasant or painful sensation, nociceptors are essential for the maintenance of the body' ... false alarm. Here, we highlight the genesis of nociceptors during development and the intrinsic properties of nociceptors that enable them to transduce, conduct, and transmit ... imperative to know about it. This is what nociceptors do—these primary sensory neurons are specialized to ...
Tópico(s): Olfactory and Sensory Function Studies
2007 - Cell Press | Neuron
Carlos F. Ibáñez, Patrik Ernfors,
... 27: 2435-2443Crossref PubMed Scopus (165) Google Scholar). Nociceptors express a diverse collection of ion channels that ... external stimuli into electrical activity. The generation of nociceptor cell diversity is believed to be controlled by ... derived neurotrophic factor) ligand family. TrkA+ and Ret+ nociceptors are also distinguished by the presence or absence ... inflammatory or neuropathic pain, respectively. While developing nonpeptidergic nociceptors lose TrkA, maintain Runx1, and gain Ret expression, ...
Tópico(s): Ion channel regulation and function
2007 - Cell Press | Neuron
Roland Schmidt, Inge Petter Kleggetveit, Barbara Namer, Tormod Helås, Otilia Obreja, Martin Schmelz, Ellen Jørum,
Multiple firing of C nociceptors upon a single electrical stimulus has been suggested to be a possible mechanism contributing to neuropathic pain. Because this phenomenon ... investigated painful neuropathy patients using microneurography and analysed nociceptors for the occurrence of multiple spiking and spontaneous activity. In 11 of 105 nociceptors, double spiking was found, with 1 fibre even ... between spontaneous activity and multiple spiking in C nociceptors, with spontaneous activity being present in 9 of ...
Tópico(s): Botulinum Toxin and Related Neurological Disorders
2011 - Lippincott Williams & Wilkins | Pain
Susan M. Carlton, Shengtai Zhou, R. Govea, Junhui Du,
... supraspinal sites. These receptors are expressed by peripheral nociceptors. We investigated whether mGluRs function as activity-dependent ... III) increased capsaicin (CAP)-induced nociceptive behaviors and nociceptor activity. In contrast, group II agonist APDC [(2R, ... prolonged stimulation endogenously activated group II/III, dampening nociceptor activation. In support of this, intraplantar GLU + LY ... heat hyperalgesia, and exogenous GLU + LY applied to nociceptors produced enhanced nociceptor activity and thermal sensitization. Intraplantar ...
Tópico(s): Ion Channels and Receptors
2011 - Society for Neuroscience | Journal of Neuroscience
Jian Zhong, Larysa Pevny, William D. Snider,
... and transduce pain-producing stimuli (referred to as nociceptors) and TrkC-expressing/NT3-dependent neurons, many of ... To address the functions of Runx1 related to nociceptor differentiation, Chen et al., 2006aChen C. Broom D. ... expression of a variety of proteins critical for nociceptor function. Thus, in conditional Runx1 nulls, expression of a number of nociceptor-specific G protein coupled receptors, ATP channels, and ... further investigate the role of Runx1 in regulating nociceptor differentiation, Chen et al. studied the spinal targeting ...
Tópico(s): Myofascial pain diagnosis and treatment
2006 - Cell Press | Neuron
Abdelkrim Alloui, Katharina Zimmermann, Julien Mamet, Fabrice Duprat, Jacques Noël, Jean Chemin, Nicolas Guy, Nicolas Blondeau, Nicolas Voilley, Cathérine Rubat-Coudert, Marc Borsotto, Georges Romey, Catherine Heurteaux, Peter W. Reeh, Alain Eschalier, Michel Lazdunski,
... small diameter DRG neurons, considered as C-fiber nociceptors (capacitance <30 pF), is presented in Figure 2. ... 2002). TREK-1 contribution to peripheral C-fiber nociceptor thermosensitivity TREK-1 contribution to peripheral C-fiber heat nociceptor was tested using the isolated skin-saphenous nerve ... TREK-1+/+ mice (P<0.001, t-test). Nociceptors from TREK-1−/− mice showed much larger responses ... together suggest that TREK-1 is important in nociceptors for the perception of low-threshold but not ... be that in most capsaicin-sensitive TRPV1 containing nociceptors, the depolarization induced by TRPV1 is compensated or ...
Tópico(s): Ion channel regulation and function
2006 - Springer Nature | The EMBO Journal
Simon McMullan, Bridget M. Lumb,
... processing of inputs arising from unmyelinated and myelinated nociceptors by (i) determining the response characteristics of Class ... preferential activation of C‐ and A‐fibre heat nociceptors, and (ii) investigating the control exerted by the ... A‐fibre; 7.5°C s −1 ) heat nociceptors revealed that, in response to C‐nociceptor activation, Class 2 neurones encode well only over ... temperatures responses decline. In contrast, responses to A‐nociceptor activation are linear and encode skin temperature over ... the magnitude of responses to A‐ and C‐nociceptor activation. However, differences were revealed in the effects ...
Tópico(s): Olfactory and Sensory Function Studies
2006 - Wiley | The Journal of Physiology
Roman Rukwied, Maurice Main, Benjamin Weinkauf, Martin Schmelz,
... 132) Google Scholar. Cowhage activates mechanoresponsive "polymodal" C-nociceptors in humans and also Aδ fibers in monkey ( ... Scholar. We therefore hypothesized that NGF sensitizes skin nociceptors in AD patients and thereby increases pruritus. In healthy volunteers, intradermally administered NGF chronically sensitizes nociceptors, resulting in a localized hyperalgesia to heat and ... Scholar. It is unclear whether such NGF-mediated nociceptor sensitization also modulates the sensitivity to various pruritic ...
Tópico(s): Circadian rhythm and melatonin
2012 - Elsevier BV | Journal of Investigative Dermatology
... cord injury (SCI) causes chronic peripheral sensitization of nociceptors and persistent generation of spontaneous action potentials (SA) in peripheral branches and the somata of hyperexcitable nociceptors within dorsal root ganglia (DRG). Here it is proposed that SCI triggers in numerous nociceptors a persistent hyperfunctional state (peripheral, synaptic, and somal) ... severe but survivable peripheral injury. In this hypothesis, nociceptor somata monitor the status of their own receptive ... and central branches and the soma itself. A nociceptor switches into a potentially permanent hyperfunctional state when ...
Tópico(s): Spinal Cord Injury Research
2012 - Frontiers Media | Frontiers in Physiology
Inge Petter Kleggetveit, Barbara Namer, Roland Schmidt, Tormod Helås, Michael Rückel, Kristin Ørstavik, Martin Schmelz, Ellen Jørum,
... to reduced pain sensitivity. We investigated peripheral C-nociceptors in painful and painless polyneuropathy patients to identify ... routine clinical methods. For a specific examination of nociceptor function, action potentials from single C-fibres including 214 C-nociceptors were recorded by microneurography. Patients with and without ... of spontaneous activity and mechanical sensitization in C-nociceptors. The mean percentage of C-nociceptors being spontaneously active or mechanically sensitized was significantly ...
Tópico(s): Peripheral Neuropathies and Disorders
2012 - Lippincott Williams & Wilkins | Pain
Laiche Djouhri, Xin Fang, Stella Koutsikou, Sally N. Lawson,
Summary After partial nerve injury, changes in uninjured nociceptors and nonnociceptors (spontaneous firing, decreased electrical thresholds, hyperpolarisation) ... a) increased percentages of C-, Ad-, and Ab-nociceptors and cutaneous Aa/b-low-threshold mechanoreceptors with ongoing/spontaneous firing; b) spontaneous firing in C-nociceptors that originated peripherally; this was at a faster ... than SNA; c) decreased electrical thresholds in A-nociceptors after SNA; d) hyperpolarised membrane potentials in A- ...
Tópico(s): Botulinum Toxin and Related Neurological Disorders
2012 - Lippincott Williams & Wilkins | Pain
Lili Gao, Simon McMullan, Laiche Djouhri, Cristian G. Acosta, Alexander A. Harper, Sally N. Lawson,
... in nociception/pain, but its expression levels in nociceptors remained unknown. We recorded I(h) magnitude and ... or Aα/β-conduction velocities (CVs). For both nociceptors andLTMs, I(h) amplitude and I(h) density ( ... 2.2 nA, -20 pA pF(-1); Aβ-nociceptors: -2.6 nA, -21 pA pF(-1); both Aδ-LTMs and nociceptors: -1.3 nA, ∼-14 pA pF(-1); C- ... nA, -7.6 pA pF(-1); and C-nociceptors: -0.26 nA, -5 pApF(-1). I(h) ... for all non-MSA LTMs, and for Aδ-nociceptors. From activation curves ∼2-7% of I(h) ... h) may be important for excitability of A-nociceptors (responsible for sharp/pricking-type pain) and Aα/ ...
Tópico(s): Neuroscience and Neural Engineering
2012 - Wiley | The Journal of Physiology
Jie Zhang, Daniel J. Cavanaugh, Michael I. Nemenov, Allan I. Basbaum,
... of TRPV1+/peptidergic or of MrgprD+/non‐peptidergic nociceptors produces modality‐specific deficits in the behavioural responses ... despite the heat responsiveness of the non‐peptidergic nociceptors. To assess whether this modality‐specific contribution is ... dorsal horn after selective ablation of the two nociceptor populations. Intrathecal capsaicin, which ablated the TRPV1+ nociceptors, abolished responsiveness of superficial and deep dorsal horn ... These findings argue strongly that TRPV1+ and MrgprD+ nociceptors provide modality‐specific contributions to the response properties ...
Tópico(s): Neurobiology and Insect Physiology Research
2012 - Wiley | The Journal of Physiology
Wayne A. Johnson, Justin W. Carder,
... wall have been characterized as high-threshold polymodal nociceptors capable of responding to noxious heat and noxious ... allodynia very similar to that observed in vertebrate nociceptors. We show that the class IV multiple-dendritic(mdIV) nociceptors are also required for a normal larval aversion ... a moist food source. Transgenic inactivation of mdIV nociceptor neurons resulted in larvae moving inappropriately into regions ... conditions of high humidity. Transgenic hyperactivation of mdIV nociceptors caused a reciprocal hypersensitivity to dry surfaces resulting ...
Tópico(s): Bee Products Chemical Analysis
2012 - Public Library of Science | PLoS ONE
William J. Barlow, Roy C. Orlando,
... mucosal breaks where it contacts and activates chemosensitive nociceptors within the esophageal mucosa. These same concepts, however, ... route for acid entry and access to the nociceptors within the mucosa; (2) episodes of heartburn in ... result in greater access of luminal acidity to nociceptors within the esophageal mucosa (see ATR below).Sustained ... acid pH in inflammatory excitation and sensitization of nociceptors in rat skin, in vitro.J Neurosci. 1995; ... they document that the sensory nerves contain chemosensitive nociceptors capable of responding to an acidic environment and, ...
Tópico(s): Helicobacter pylori-related gastroenterology studies
2005 - Elsevier BV | Gastroenterology
P. Charles Garell, Sandra L. B. McGillis, Joel D. Greenspan,
1. The responses of feline cutaneous nociceptors were examined in vivo by systematically manipulating the intensive and spatial dimensions of mechanical stimulation. A computer-controlled motor was used to apply prescribed forces (5-90 g) to a nociceptor's receptive field, with flat-tipped, cylindrical probes ... ramp-and-hold stimulus of controlled force, most nociceptors showed a slowly adapting (SA) response throughout the stimulus. In this way, nociceptors resembled low-threshold SA mechanoreceptors. However, in contrast ...
Tópico(s): Healthcare and Venom Research
1996 - American Physiological Society | Journal of Neurophysiology