... Israel along a seven mile front described as nonsense. 1955. FO 371/115903-0019. English. FO 371/ ...
1955 - Gale Group | ArchivesUnbound Arabi Israeli
Martin Weigert, Erich Lanka, Alan Garen,
... oxperiments showed that the triplet UAG was the nonsense condon produced by the N1 class of alkaline phosphatase nonsense mutations. In the present experiments UAA has been identified as a second nonsense codon produced by the N2 class of alkaline phosphatase nonsense mutations. The composition of each nonsense codon was established on the basis of amino ... a result of mutationally induced alterations of the nonsense codons. The substitution data further indicate that UGA ... Escherichia coli and might act as a third nonsense codon.
Tópico(s): Fungal and yeast genetics research
1967 - Elsevier BV | Journal of Molecular Biology
Cobbett, William, Grenville, William Wyndham Grenville, Baron,
Caption title. Book.
0000 - Gale Group | The Making of Modern World
Charles Yanofsky, Junetsu Ito,
... synthesis of tryptophan enzymes, whereas amber and ochre nonsense alterations invariably had polar effects—they reduced the ... the operator region than the gene with the nonsense mutation. Nonsense alterations on the side of a gene close ... enzyme formation. Represser-deficient stocks were prepared with nonsense alterations in two different genes in the operon. Each nonsense alteration acted independently in reducing the relative rate ... of the operon. Repressor-deficient stocks with two nonsense alterations in the same gene behaved in co- ...
Tópico(s): Polyamine Metabolism and Applications
1966 - Elsevier BV | Journal of Molecular Biology
"Re-printed from the Manchester and Salford advertiser, of July 28th, 1838." Book.
0000 - Gale Group | The Making of Modern World
Zhenguo Zhang, Dedong Xin, Ping Wang, Li Zhou, Landian Hu, Xiangyin Kong, Laurence D. Hurst,
Abstract Background Nonsense-mediated decay is a mechanism that degrades mRNAs with a premature termination codon. That some exons have premature ... be a means to prevent costly translation. Alternatively, nonsense-mediated decay can be regulated under certain conditions ... a means to up-regulate transcripts needed when nonsense-mediated decay is suppressed. Results To resolve this issue we examined the properties of putative nonsense-mediated decay targets in humans and mice. We ... to 4% of genes are probably subject to nonsense-mediated decay, and that the premature termination codon ...
Tópico(s): RNA modifications and cancer
2009 - BioMed Central | BMC Biology
Illustrated t.-p. Printed on one side of leaf only. Book.
0000 - Gale Group | Sabin
Ming Du, Kim M. Keeling, Liming Fan, Xiaoli Liu, David M. Bedwell,
... found that PAA also increased the in vivo nonsense suppression induced by gentamicin. Following the withdrawal of ... the use of gentamicin to suppress disease-causing nonsense mutations will require their long term administration, the ... found that PAA also increased the in vivo nonsense suppression induced by gentamicin. Following the withdrawal of ... the use of gentamicin to suppress disease-causing nonsense mutations will require their long term administration, the ... suppress translation termination at disease-causing premature stop (nonsense) mutations and partially restore the expression of functional ...
Tópico(s): Cystic Fibrosis Research Advances
2009 - Elsevier BV | Journal of Biological Chemistry
Caption title. Signed: William Martin. "The explosion"--p. 2. Book.
0000 - Gale Group | The Making of Modern World
Fabrice Lejeune, Yasuhito Ishigaki, Xiaojie Li, Lynne E. Maquat,
... complex recruits Upf3 and Upf2, which function in nonsense-mediated mRNA decay (NMD). Both Upf proteins are ... An additional quality control, called mRNA surveillance or nonsense-mediated mRNA decay (NMD), degrades mRNAs that prematurely ... for NMD was based on several criteria: (i) nonsense-containing CBP80-bound mRNA is reduced in abundance to an extent that is comparable to nonsense-containing eIF4E-bound mRNA, and CBP80-bound mRNA ... a precursor to eIF4E-bound mRNA; (ii) the nonsense-mediated reduction in the abundance of CBP80-bound ...
Tópico(s): RNA modifications and cancer
2002 - Springer Nature | The EMBO Journal
Pomeroy, Mark M. (Mark Mills), Howard, Justin H.,
Book.
0000 - Gale Group | Sabin
Jun Wang, Vita M. Vock, Shulin Li, O. Renee Olivas, Miles Wilkinson,
Nonsense-mediated decay (NMD) is an RNA surveillance pathway that degrades mRNAs containing premature termination codons (PTC). ... that they are down-regulated in response to nonsense codons in the nuclear fraction of cells. This ... as the only well recognized entity that recognizes nonsense codons is the cytoplasmic translation apparatus. Therefore, we ... regulation of TCR-β transcripts in response to nonsense codons requires several features of translation, including an ... proteins encoded by non-productively rearranged TCR genes. Nonsense-mediated decay (NMD) is an RNA surveillance pathway ...
Tópico(s): Cytokine Signaling Pathways and Interactions
2002 - Elsevier BV | Journal of Biological Chemistry
Project Gutenberg
Tony Rushton, Patrick Soper, Phil Yates, Jon Ashworth, Cath Urquhart, Raymond Snoddy Media Editor, Ian Bennett, David Adams, Stella Shamoon, Robert Cole, Portia Colwell, Andrew Pierce, Douglas Emmott, Sally Brock, James Moore, Grace Bradberry, Johnny Dee, A. S., Jane MacQuitty, Gary Neville, John Morgan, Jill Hartley, Lesley Russell, Julian Lee, Bernard Kaukas, Mark Souster, Richard Hobson, Gershon Ellenbogen, Paul Sanders, Ivo Tennant, Robert Lea, Michael Evans Defence Editor, Douglas Friedli, James Bone, Stephanie Theobald, Clive Davis, John Draper, Claire Brereton, Elizabeth Judge, Ian Cundell, M. T., Richard Eaton, Sharon Linnard, Dominic Bradbury, K. J. Barker, Christine Buckley, James Doran, Allan Hall and Roland Watson, Tony Patrick, Clare Stewart, Jane Wilson, John Thicknesse, Antonia Senior, Carl Evans, Conal Urquhart, Pat Gibson, D. J. M. Turner, Norman Davies, John Clarke, D. R., D. G. Duke, Thrasy Petropoulos, Melanie Tringham, Stewart Tendler Crime Correspondent, David Charter Education Correspondent, Geoffrey Owen, Dominic Walsh, Steve Bird, Ruth Gledhill, Stephen Anderton's, Tim Reid, Ruth Gledhill Religion Correspondent, Dalya Alberge Arts Correspondent, David Hunter, Peter Hughes, Jo Morris, Stephen Farrell, Oliver Wright, Mark Inglefield, John Hancock, Peter Millar, T. P., Roland Watson Political Watson, Alice Lagnado, Frances Bissell, David Hands, P. B., Charles Bremner, Helen Rumbelow, Kevin McCarra and Stephen Wood, Conal Urquhart and Richard Ford, Peter Barnard, Anthea Lawson, Michael Gardner, Patience Wheatcroft Business Editor, Derwent May, James Urquhart, James Doran City Correspondent, Mary Loudon, Jasper Gerard, Russell Kempson, Paula Hawkins, Anna Moore, Daniel McGrory, Paul Armstrong, Ed Potton, Justin Langer, Stephen Anderton, M. Hammerton, Lea Paterson and Philip Webster, David Lister, Steve Deeks, Michael Theodoulou, Christopher Martin-Jenkins, James Aufenast, Toni Carragher, Stephen Farrell South Asia Correspondent, Rob Wright, Geoffrey Dean, Christina Koning, Stephen Wood, Adam Jones, J. H. Baker, Raymond Keene, Vaughan Freeman, David Robinson, Clive Mathieson, Matt Dickinson, Lucy Pinney, Anne Boston, James Allcock, Christine Buckley Industrial Editor, Graham Doswell, Managing Director, Jeannette Hyde, Clive Petty, Walter Cairns, Chris Ayres Media Business Correspondent, Adam Jones and James Doran, Oliver Holt, Caroline Donald, Damian Whitworth, Christopher Martin-Jenkins Chief Cricket Correspondent, Chris Porteous, John Stern, Nick Hasell, Dalya Alberge, Robin Renwick, David Hands Rugby Correspondent, Martin Fletcher European Correspondent, Anne Ashworth, Elizabeth James, Jane Shilling, Mel Webb, Srikumar Sen Boxing Correspondent, Kevin McCarra, Amanda Craig, Chris McGrath, Clare Catford, Tim Wapshott, William McConnell, Russell Jenkins, Michael Austin, Clarissa Hyman, Lionel Leventhal, Jane Owen, Ben MacIntyre, Helen Pridham, Michael Dobbs, John Goodbody Sports News Correspondent, Chlöe Bryan-Brown, Richard Beeston Diplomatic Editor, Brenda Jenkinson, Richard Miles, John Naish, Graham Searjeant, Annabelle Thorpe, Nick Roe, Geoffrey Rowell, Martin Waller, Minty Clinch, Chris Ayres, Peter Ingham, Nigel Hawkes Science Editor, Danny Baker, Fran Littlewood, Philip Johnston, Stuart Birch, Jill Crawshaw, Richard Morrison, Alyson Rudd, Tom Chesshyre, Elizabeth Buchan, Valerie Grove, Adam Sherwin, Hugh Weatherly, Allan Hall, Robert Whymant, Kirsty Young, Daisy Hope-Johnston, Jan Godfrey, Lea Paterson Economics Correspondent, Roland Watson Chief Political Correspondent, Sally Patten, Nick Baty, Spencer Bright, Cath Urquhart Travel Editor, Fraser Nelson Retail Correspondent, Maurice Fitzpatrick, Patience Wheatcroft, Christopher Irvine, William Gray, William Feaver, Susan Emmett, Arthur Leathley Transport Correspondent,
... No Title Multiple Display Advertising Items Why talking nonsense is bad for baby The BabyTalk programme will ... could save lives, says Annabelle Thorpe Why talking nonsense is bad for Baby Why talking nonsense is ...
2000 - Gale Group | TDA
James D. Fackenthal, Luca Cartegni, Adrian R. Krainer, Olufunmilayo I. Olopade,
... HT Serova-Sinilnikova OM Lenoir GM A BRCA1 nonsense mutation causes exon skipping.Am J Hum Genet. ... AR A mechanism for exon skipping caused by nonsense or missense mutations in BRCA1 and other genes. ... by Valentine (Valentine, 1998Valentine CR The association of nonsense codons with exon skipping.Mutat Res. 1998; 411: ... S Krainer A Listening to silence and understanding nonsense: exonic mutations that affect splicing.Nat Rev Genet. ... AR A mechanism for exon skipping caused by nonsense or missense mutations in BRCA1 and other genes. ...
Tópico(s): CRISPR and Genetic Engineering
2002 - Elsevier BV | The American Journal of Human Genetics
Ernest Newman, A. L. Rowse, A. T. Johnson, A. A. Milne, L. A. Luxmoore, Iain Lang "Sunday Times" War Correspondent, E. Colston Shepherd Air Correspondent of "The Sunday Times"\, Noel Deerr, Maria Steuart, C. Strickland, Walter Lippmann, Yarborough, W. Kay Robinson, Ludwig Koch, E. Shinwell, Ralph Straus, Harold Hobson, J. Boggins, C. M. Newton, Eric Newton, Norman Crump City Editor, Margaret H. Lechmere-Oertel, James Agate, John B. Chubb, A. Radclyffe Dugmore, Alfred Hills, Patrick Donner, Julia Herrick, R. H., Michael Kelly, Rev. S. M. Berry D. D., T. C. Love, Desmond Shawe-Taylor, Paul Einzing, Desmond MacCarthy, G. D. Summers, James McDowall "The Sunday Times" War Correspondent, Frank MacDermot Special Correspondent of "The Sunday Times", E. H. Blakeney, H. K. Thorold, G. E. Carpenter, A. W. J. Davies, Sayar, Dilys Powell, Alexander Werth "Sunday Times" Special Correspondent, George Mills, J. B., Elton Ede, Rev. R. W. A. Ward, J. Robinson, Maurice Watts "The Sunday Times" Special Correspondent, O. H. Brandon "The Sunday Times" Special Correspondent, R. W. Thompson "Sunday Times" Special Correspondent, J. P. Jordan, S. E. G. Tutenberg, E. Graham-Little M. P.,
... Building a House "The Honeywood Settlement" Sense and Nonsense About Politics Everybody's Political What's What. ... Constable. 10s.) Forgiveness and the Enemy Sense and Nonsense About Politics Multiple Display Advertising Items Harrap Eyre & ...
1944 - Gale Group | Sunday Times HA GDA
... favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinked InMendeleyWechatReddit Figures & Info The nonsense-mediated decay (NMD) RNA surveillance pathway detects and ... other known mammalian gene transcripts in response to nonsense codons. Here, we demonstrate that this is not ... down-regulatory elements identified that act upstream of nonsense codons. Introduction Nonsense-mediated decay (NMD) is an RNA surveillance pathway ... harboring premature termination codons (PTCs) generated by frameshifts, nonsense mutations, splicing errors and transcriptional errors. This pathway ...
Tópico(s): RNA modifications and cancer
2002 - Springer Nature | The EMBO Journal
Andrew Robson, Raymond Snoddy Media Editor, Suzannah Olivier, David Charter Health Correspondent, Robert Cole, Parry Mitchell, Chairman, James Moore, Patricia Davies, Grace Bradberry, Sarah Potter, Gary Duncan, Peter Lansley, Russell Kemspon, Mark Atherton and Gary Duncan, Mark Souster, Rupert Earle, Linda Tsang, Richard Hobson, Philip Howard, Ian Cobain, Hilary Finch, David Smith, Joanna Bale, Nigel Hawkes and Philip Webster, Jon Belk, Elizabeth France, Information Commissioner, Ila R. Mehta, Nahid Rahman, Gabrielle Starkey, Edward Davies, Steve Knott, John Bungey, Kevin Eason, Valerie Elliott and Paul Wilkinson, Jim Dixon, Joe Joseph, Giles Coren, Andrew Norfolk, John O'Leary Education Editor, Martin Fletcher, Ben Webster Transport Correspondent, Valerie Elliott Countryside Editor, Ian Blackshaw (Lecturer), Dominic Walsh, Steve Bird, Tom Baldwin and Joanna Bale, Ruth Gledhill, James Bone and Sam Kiley, Debra Craine, Victoria Segal, James Harcus, Dalya Alberge Arts Correspondent, Peter Pallot, Libby Purves, Richard Ford Home Correspondent, Alan Hamilton, Robin Young, Oliver Wright, Paula Pridham, Rodney Milnes, Matt Sims, Alice Lagnado, Miranda Ingram, David Hands, John E. Strafford, Chairman, Peter Barnard, Mark Court, Clive Mathieson Telecoms Correspondent, Caroline Merrell Banking Correspondent, Angela Jameson, Alistair B. Cooke, General Secretary, Vanora Bennett, Sally Jones, Felipe Fernandez-Armesto, Edward Fennell, Oliver Kay, Rick Broadbent, Matt Dickinson Football Correspondent, T. F. McCrickard, Sam Coates, Christopher Martin-Jenkins, Simon de Bruxelles, John Hopkins Golf Correspondent, Geoffrey Dean, Rob Wright, Meg Henderson, Francis Bennion, David Powell Athletics Correspondent, George Wood, Raymond Keene, Adam Sage, Paul Wilkinson and Michael Horsnell, Philip Webster and Roland Watson, Paul Wilkinson, Rajnikant J. Mehta, A. F. Green, Ambassador, Christopher Walker Chief Ireland Correspondent, Adam Fresco and David Lister, Fred Cosstick, Roger Foord, Helen Nugent, Richard Owen, Damian Whitworth, David Pannick QC, Nick Hasell, Grania Langdon-Down, V. N. Bingham, National President, Veronica Cowan, Jonathan Seltzer, Ben Hammersley, Nick Szczepanik, John Goodbody, John Cooper, Anatole Kaletsky and Robin Marris, James Doran, Melissa Kite Political Correspondent, Robert Crampton, Tim Hames, Paul McCann Media Correspondent, Matthew Parris, George Caulkin, Caitlin Moran, Alan Lee, Ben MacIntyre, Patience Wbeatcroft, John Malpas, Michael Dynes, David McLaughlin, Fraser Nelson, Gary Duncan Economics Correspondent, Martin Waller, Christopher Irvine, Lisa Verrico, Carl Mortished International Business Editor, Nigel Hawkes Health Editor, Laura Peek, Philip Webster, Paul McCann and James Landale, Stephen Dalton, Alan Sargent, Alyson Rudd, Frances Gibb, Sam Kiley, Julian, Norman Williams, James Christopher, Adam Sherwin, Simon Crompton, Sally Patten, Roland Watson Chief Political Correspondent, Anthony Howard, Edward Gorman Sailing Correspondent, Patience Wheatcroft, Nick Faldo,
... discovered America in 1485, writes Richard Owen. What nonsense, says Felipe Fernàndez-Armestro 'His real motives were ... up … Case for promotion Doctor's disappointment Patent nonsense LawWeek Legal laundry Carillion Homebase UWE An exciting ...
2001 - Gale Group | TDA
Edward Gorey, Children's Literature, and Nonsense Verse Kevin Shortsleeve (bio) "A lot of my books I've intended for children primarily." —Edward Gorey (Wynne-Jones 543) "Ted Gorey ... 31), and Celia Anderson and Marilyn Apseloff, in Nonsense Literature for Children: Aesop to Seuss, confirmed that ... indicative of their affiliation with a subgenre of nonsense literature (35). Completing the spectrum, Amy Hanson exhibited ... further, that his contributions to the field of nonsense verse are both unique and valuable precisely because ...
Tópico(s): American and British Literature Analysis
2002 - Johns Hopkins University Press | Children's Literature Association quarterly
Andrew Robson, Simon Barnes Chief Sports Writer, Jon Ashworth, Helen Studd, Robert Cole, Andrew Pierce, DJM, Alan King-Hamilton, Peter Lansley, David Middleton, Paul Hoggart, Mark Souster, Frances Gibb Legal Editor, Sam Lister and Michael Horsnell, Richard Hobson, Patrick Barkham and Gillian Harris, Ian Winrow, Philip Howard, Hilary Finch, David Chater, John Kennett, Lucia Van Der Post, Carl Mortished, Patrick Kidd, David Brooks, Patrick Barkham, Anthony Wigram, Kevin Eason, Raymond Snoddy, Andrew Norfolk, Douglas Tuckey, Ben Webster Transport Correspondent, Caroline Raphael, Graham Booth, Stewart Tendler Crime Correspondent, Mark Atherton and Joe Morgan, Jennai Cox Fitness Editor, Daniel McGrory and Sam Lister, Michael Lazarus, Dominic Walsh, James Doran Wall Street Correspondent, Shirley English, Rory Watson, Gary Jacob, Joe Morgan, Tim Reid, Daniel Finkelstein, Jon Hills-Jones, Dalya Alberge Arts Correspondent, Phoebe Greenwood, Jeremy Hunt, Nick Robinson, Robin Young, Stephen Farrell, Suzanne Houchin, John Harman, Kevin Eason Motoring Editor, Roland Watson, Paul Ridley, Emma Hartley and Philip Pank, Richard Horrison, Helen Rumbelow, Matt Dickinson Chief Football Correspondent, Angela Jameson, Russell Kempson, Paula Hawkins, John Price, Vanora Bennett, David Rowan, Daniel McGrory, Tony Halpin Education Editor, Roland Watson and Elaine Monaghan, Richard Littlejohn, Neil Harman, Rick Broadbent, Anthony Browne and Paul Simons, Joyce Quin, Tom Baldwin, Jill Sherman Whitehall Editor, Paul Sexton, Simon de Bruxelles, Geoffrey Dean, Elaine Monaghan, David Watts, Mark Souster and Christopher Irvine, Daniel McLaughun, Helen Nugent and David Charter, Paul Klauke, David Powell Athletics Correspondent, Dan Sabbagh Telecoms Correspondent, Raymond Keene, Lewis Smith, Matthew Pryor, Christine Buckley Industrial Editor, Benji Wilson, Robert Galster, Xan Rice and Gary Duncan, Greg Hurst Parliamentary Correspondent, Caroline Merrell, Terry Arthur, Chris Campling, Russell Hotten, Cathy Harris, Richard Owen, Roger Boyes, Peter Dixon, Nick Hasell, Philip Webster, Political Editor, Kevin Baker, Owen Slot Chief Sports Reporter, Alison Beckett, Michael Jewes, Mike Mulvihill, Inna Tysoe, John Allison, Jenny Davey Anne Spackman and Gary Duncan, Christopher Heneghan, John Goodbody, James Doran, Tim Reid and Daniel McGrory, Trevor Stevenson, Tim Hames, Ian Johns, Denis Watkins, Gary Duncan, Joe Bolger and Caroline Merrell, Graham Searjeant Financial Editor, Charles Bremner Roger Boyes and Rosemary Bennett, Anjana Ahuja, Chris McGrath, George Caulkin, Russell Jenkins, Glen Owen Education Correspondent, Caitlin Moran, Mark Court Health Industries Correspondent, Peter Riddell, Ben MacIntyre, Ben Webster, David Charter Chief Political Correspondent, Michael Dynes, Richard Miles, David Sinclair, Simon Jenkins, Robert Whelan, Martin Waller, Gary Duncan Economics Correspondent, Chris Ayres, Lisa Verrico, Nick Bevan, Philippa Kennedy, Emma Hartley, Nigel Hawkes Health Editor, Peter James, Benedict Nightingale, Sarah Butler, Ashling O'Connor, Stephen Dalton, Bill Edgar, Tony Halpin, Michael Evans, Ashley Tatham, Angela Jameson and Sarah Butler, Edward Gorman Sailing Correspondent, Tim Johnston, Michael Evans Defence Editor and Russell Hotten, Robin Shepherd, Giles Whiting, Patience Wheatcroft, Christopher Irvine, Damian Barr,
... Bafta Nominations including Best Film Massive carbuncies and nonsense Business Wales A-level system is 'close to ... injustices Enforce child sex laws before this Pc nonsense Failure of Nerve The carrier contract should have ...
2003 - Gale Group | TDA
Jun Wang, Jayanthi Gudikote, O. Renee Olivas, Miles Wilkinson,
Nonsense‐mediated decay (NMD) is an RNA surveillance mechanism that degrades mRNAs containing premature termination (nonsense) codons. The second signal for this pathway in ... be at least ∼55 nucleotides downstream of the nonsense codon. Although the functional significance of this ‘−55 ... this rule. Rather than a definitive boundary position, nonsense codons had a polar effect, such that nonsense codons distant from the terminal downstream intron triggered robust NMD and proximal nonsense codons caused modest NMD. We identified a region ...
Tópico(s): RNA modifications and cancer
2002 - Springer Nature | EMBO Reports