Gregory G. Schwartz, Michael Szarek, Vera A. Bittner, Rafael Díaz, Shaun G. Goodman, J. Wouter Jukema, Ulf Landmesser, Patricio López‐Jaramillo, Garen Manvelian, Robert Pordy, Michel Scemama, Peter Sinnaeve, Harvey D. White, Philippe Gabríel Steg, Gregory G. Schwartz, Philippe Steg, Deepak L. Bhatt, Vera A. Bittner, Rafael Diaz, Shaun G. Goodman, Robert A. Harrington, J. Wouter Jukema, Michael Szarek, Harvey D. White, Andreas M. Zeiher, Pierluigi Tricoci, Matthew T. Roe, Kenneth W. Mahaffey, Jay M. Edelberg, Corinne Hanotin, Guillaume Lecorps, Angèle Moryusef, Robert Pordy, William J. Sasiela, Jean‐François Tamby, Rafael Diaz, Philip E. Aylward, Heinz Drexel, Peter Sinnaeve, Mirza Dilic, Renato D. Lopes, Nina Gotcheva, Shaun G. Goodman, Juan-Carlos Prieto, Yong Huo, Patricio López‐Jaramillo, Ivan Pećin, Zeljko Reiner, Petr Ošťádal, Steen Hvitfeldt Poulsen, Margus Viigimaa, Markku S. Nieminen, Nicolas Danchin, Vakhtang Chumburidze, Nikolaus Marx, Evangelos Liberopoulos, Pablo Carlos Montenegro Valdovinos, Hung-Fat Tse, Róbert Gábor Kiss, Denis Xavier, Doron Zahger, Marco Valgimigli, Takeshi Kimura, Hyo Soo Kim, Sang-Hyun Kim, Andrejs Ērglis, Aleksandras Laucevičius, Sasko Kedev, Khalid Yusoff, Gabriel Arturo Ramos López, Marco Alings, Harvey D. White, Sigrun Halvorsen, Roger M. Correa Flores, Rody G. Sy, Andrzej Budaj, Joao Morais, Maria Dorobantu, Yuri Karpov, Arsen D. Ristic, Terrance Chua, Jan Murin, Zlatko Fras, Anthony J. Dalby, José Tuñón, H. Asita de Silva, Emil Hagström, Ulf Landmesser, Christian Müller, Chern‐En Chiang, Piyamitr Sritara, Sema Güneri, Alexander Parkhomenko, Kausik K. Ray, Patrick M. Moriarty, Matthew T. Roe, Robert A. Vogel, Bernard Chaitman, Sheryl F. Kelsey, Anders Olsson, Jean‐Lucien Rouleau, Maarten L. Simoons, Karen P. Alexander, Chiara Meloni, Robert Rosenson, Eric J.G. Sijbrands, Pierluigi Tricoci, John H. Alexander, Luciana Armaganijan, Akshay Bagai, Maria Cecilia Bahit, James M. Brennan, Shaun Clifton, Adam D. DeVore, Shalonda Deloatch, Sheila Dickey, Keith Dombrowski, Grégory Ducrocq, Zubin J. Eapen, Patricia Endsley, Arleen Eppinger, Robert W. Harrison, Connie Ng Hess, Mark A. Hlatky, J. Dedrick Jordan, Joshua W. Knowles, Brad J. Kolls, David F. Kong, Sergio Leonardi, Linda Lillis, Renato D. Lopes, David J. Maron, Kenneth W. Mahaffey, Jill Marcus, Robin Mathews, Rajendra H. Mehta, Robert J. Mentz, Humberto Graner Moreira, Chetan B. Patel, Sabrina Bernardez Pereira, Lynn Perkins, Thomas J. Povsic, Etienne Puymirat, Matthew T. Roe, W. Schuyler Jones, Bimal R. Shah, Matthew W. Sherwood, Kenya Stringfellow, Darin Sujjavanich, Mustafa Toma, Charlene Trotter, Sean F.P. van Diepen, Matthew D. Wilson, Andrew Tze-Kay Yan, Lilia Schiavi, Marcelo Garrido, Andrés F. Alvarisqueta, Sonia A. Sassone, Anselmo P. Bordonava, Alberto Enrique Alves de Lima, Jorge M. Schmidberg, Ernesto Duronto, Orlando C. Caruso, Leonardo P. Novaretto, Miguel Angel Hominal, Oscar Montaña, Alberto Caccavo, Oscar A. Gomez Vilamajo, Alberto J. Lorenzatti, Luis Cartasegna, Gustavo A. Paterlini, Ignacio MacKinnon, Guillermo D. Caime, Philippe Gabríel Steg, Oscar Salomone, Oscar R. Codutti, Horacio O. Jure, Julio O.E. Bono, Adrian D. Hrabar, Julio Vallejos, Rodolfo A. Ahuad Guerrero, Federico Novoa, Cristian A. Patocchi, Cesar Javier Zaidman, Maria E. Giuliano, Ricardo D. Dran, Marisa L. Vico, Gabriela S. Carnero, Pablo N. Guzman, Juan C. Medrano Allende, Daniela F. Garcia Brasca, Miguel H Bustamante Labarta, S Nani, Eduardo D.S. Blumberg, Hugo Colombo, Alberto Liberman, Victorino Fuentealba, Héctor Luciardi, Gabriel Waisman, Mario A Berli, Ruben O Garcia Duran, Horacio G Cestari, Hugo A Luquez, Jorge A Giordano, Silvia S Saavedra, Gerardo Zapata, Osvaldo Costamagna, Susana C. Llois, J. Waites, Nicholas Collins, Allan Soward, Philip E. Aylward, Chris L.S. Hii, Philip E. Aylward, James Shaw, Margaret Arstall, John Horowitz, Daniel Ninio, James Frederick Rogers, David Colquhoun, Romulo E Oqueli Flores, Philip Roberts‐Thomson, O. Raffel, Sam J. Lehman, Constantine Aroney, Steven Coverdale, P. Garrahy, Gregory Starmer, Mark Sader, Patrick A. Carroll, Ronald Dick, Robert Zweiker, Uta Hoppe, Heinz Drexel, Kurt Huber, Rudolf Berger, Georg Delle-Karth, Bernhard Frey, Dirk Faes, Kurt Hermans, B. Pirenne, Attilio Leone, Etienne Hoffer, Peter Sinnaeve, Mathias C.M. Vrolix, Luc De Wolf, Bart Wollaert, Marc Castadot, Karl Dujardin, Christophe Beauloye, Geert Vervoort, Harry Striekwold, Carl Convens, John Roosen, Emanuele Barbato, Marc Claeys, Frank Cools, Ibrahim Terzić, Fahir Baraković, Zlatko Midzic, Belma Pojskic, Emir Fazlibegovic, Mirza Dilic, Azra Durak-Nalbantic, Mehmed Kulić, Dusko Vulic, Adis Muslibegovic, Boris Goronja, Gilmar Reis, Luciano Sousa, José Carlos Nicolau, Flavio E Giorgeto, Ricardo Pereira Silva, Lilia Nigro Maia, Rafael Rech, Paulo R.F. Rossi, Maria José AG Cerqueira, Norberto Duda, Renato Kalil, Adrian Kormann, José Antonio M. Abrantes, Pedro Pimentel Filho, Ana Priscila Soggia, Mayler O.N. de Santos, Fernando Neuenschwander, Luiz Carlos Bodanese, Yorghos L Michalaros, Freddy G. Eliaschewitz, Maria H Vidotti, Paulo Leães, Roberto V. Botelho, Sérgio Kaiser, Euler Roberto Fernandes Manenti, Dalton B. Precoma, José Carlos Moura Jorge, Pedro Silva,
Guidelines recommend nonstatin lipid-lowering agents in patients at very high risk for major adverse cardiovascular events (MACE) if low-density lipoprotein cholesterol (LDL-C) remains ≥70 mg/dL on maximum tolerated statin treatment. It is uncertain if this approach benefits patients with LDL-C near 70 mg/dL. Lipoprotein(a) levels may influence residual risk. In a post hoc analysis of the ODYSSEY Outcomes (Evaluation of Cardiovascular Outcomes After an Acute Coronary Syndrome During Treatment With Alirocumab) ...
Elsevier BV
Gregory G. Schwartz, Michael Szarek, Vera Bittner, Deepak L. Bhatt, Rafael Díaz, Shaun G. Goodman, J. Wouter Jukema, Megan Loy, Garen Manvelian, Robert Pordy, Harvey D. White, Philippe Gabríel Steg, Gregory G. Schwartz, Philippe Gabríel Steg, Deepak L. Bhatt, Vera Bittner, Rafael Díaz, Shaun G. Goodman, Robert A. Harrington, J. Wouter Jukema, Michael Szarek, Harvey D. White, Andreas M. Zeiher, Pierluigi Tricoci, Matthew T. Roe, Kenneth W. Mahaffey, Jay M. Edelberg, Corinne Hanotin, Guillaume Lecorps, Angèle Moryusef, Robert Pordy, William J. Sasiela, Jean‐François Tamby, Philip E. Aylward, Heinz Drexel, Peter Sinnaeve, Mirza Dilić, Renato D. Lópes, Nina Gotcheva, Juan-Carlos Prieto, Yong Huo, Patricio López‐Jaramillo, Ivan Pećin, Željko Reiner, Petr Ošťádal, Margus Viigimaa, Markku S. Nieminen, Vakhtang Chumburidze, Nikolaus Marx, Nicolas Danchin, Evangelos Liberopoulos, Pablo Carlos Montenegro Valdovinos, Hung‐Fat Tse, Róbert Gábor Kiss, Denis Xavier, Doron Zahger, Marco Valgimigli, Takeshi Kimura, Hyo Soo Kim, Sang‐Hyun Kim, Andrejs Ērglis, Aleksandras Laucevičius, Sasko Kedev, Khalid Yusoff, Gabriel Arturo Ramos López, Marco Alings, Sigrun Halvorsen, R. Correa, Andrzej Budaj, João Morais, Maria Dorobanţu, Yuri Karpov, Arsen D. Ristic, Terrance Chua, Ján Murín, Zlatko Fras, Anthony J. Dalby, José Tuñón, H. Asita de Silva, Emil Hagström, Ulf Landmesser, Chern-En Chiang, Piyamitr Sritara, Sema Guneri, Alexander Parkhomenko, Kausik K. Ray, Patrick M. Moriarty, Robert A. Vogel, Bernard Chaitman, Sheryl F. Kelsey, Anders Olsson, Jean‐Lucien Rouleau, Maarten L. Simoons, Karen Alexander, Chiara Meloni, Robert S. Rosenson, Eric J.G. Sijbrands, Pierluigi Tricoci, John H. Alexander, Luciana Armaganijan, Akshay Bagai, Maria Cecilia Bahit, J. Matthew Brennan, Shaun Clifton, Adam D. DeVore, Shalonda Deloatch, Sheila Dickey, Keith Dombrowski, Grégory Ducrocq, Zubin J. Eapen, Patricia Endsley, Arleen Eppinger, Robert W. Harrison, Connie Ng Hess, Mark A. Hlatky, J. Dedrick Jordan, Joshua W. Knowles, Brad J. Kolls, David F. Kong, Sergio Leonardi, Linda Lillis, David J. Maron, Jill Marcus, Robin Mathews, Rajendra H. Mehta, Robert J. Mentz, Humberto Graner Moreira, Chetan B. Patel, Sabrina Bernardez‐Pereira, Lynn Perkins, Thomas J. Povsic, Etienne Puymirat, W. Schuyler Jones, Bimal R. Shah, Matthew W. Sherwood, Kenya Stringfellow, Darin Sujjavanich, Mustafa Toma, Charlene Trotter, Sean van Diepen, Matthew D. Wilson, Andrew T. Yan, Lilia Schiavi, Marcelo Garrido, Andrés F. Alvarisqueta, Sonia A Sassone, Anselmo P. Bordonava, Alberto Enrique Alves de Lima, Jorge M. Schmidberg, Ernesto Duronto, Orlando C. Caruso, Leonardo P. Novaretto, Miguel Angel Hominal, Oscar Montaña, Alberto Caccavo, Oscar A. Gomez Vilamajo, Alberto J. Lorenzatti, Luis Cartasegna, Gustavo A. Paterlini, Ignacio MacKinnon, Guillermo D. Caime, Philippe Gabríel Steg, Oscar Salomone, Oscar R. Codutti, Horacio O. Jure, Julio O.E. Bono, Adrian D. Hrabar, Julio Vallejos, Rodolfo A. Ahuad Guerrero, Federico Novoa, Cristian A. Patocchi, Cesar Javier Zaidman, María Elena Giuliano, Ricardo D. Dran, Marisa L. Vico, Gabriela S. Carnero, Pablo N. Guzman, Juan C. Medrano Allende, Daniela F. Garcia Brasca, Miguel H Bustamante Labarta, S Nani, Eduardo D.S. Blumberg, Hugo Colombo, Alberto Liberman, Victorino Fuentealba, Héctor Luciardi, Gabriel Waisman, Mario A Berli, Ruben O Garcia Duran, Horacio G. Cestari, Hugo A Luquez, Jorge A Giordano, Silvia S Saavedra, Gerardo Zapata, Osvaldo Costamagna, Susana Llois, J. Waites, Nicholas Collins, Allan Soward, Chris L.S. Hii, James Shaw, Margaret Arstall, John D. Horowitz, Daniel M. Ninio, James Frederick Rogers, David Colquhoun, Romulo E Oqueli Flores, Philip Roberts‐Thomson, Owen Raffel, Sam J. Lehman, Constantine Aroney, Steven Coverdale, P. Garrahy, Gregory Starmer, Mark Sader, Patrick A. Carroll, Ronald Dick, Robert Zweiker, Uta Hoppe, Kurt Huber, Rudolf Berger, Georg Delle-Karth, Bernhard Frey, Franz Weidinger, Dirk Faes, Kurt Hermans, B. Pirenne, Attilio Leone, E Hoffer, Mathias C.M. Vrolix, Luc De Wolf, Bart Wollaert, Marc Castadot, Karl Dujardin, Christophe Beauloye, Geert Vervoort, Harry Striekwold, Carl Convens, John Roosen, Emanuele Barbato, Marc Claeys, Frank Cools, Ibrahim Terzić, Fahir Barakovic, Zlatko Midzic, Belma Pojskic, Emir Fazlibegovic, Mehmed Kulić, Azra Durak-Nalbantić, Duško Vulić, Adis Muslibegovic, Boris Goronja, Gilmar Reis, Luciano Sousa, José Carlos Nicolau, Flavio E Giorgeto, Ricardo Pereira Silva, Lília Nigro Maia, Rafael Rech, Paulo R.F. Rossi, Maria José AG Cerqueira, Norberto Duda, Renato Kalil, Adrian Kormann, José Antonio M Abrantes, Pedro Pimentel Filho, Ana Priscila Soggia, Mayler O.N. de Santos, Fernando Neuenschwander, Luiz Carlos Bodanese, Yorghos L Michalaros, Freddy G. Eliaschewitz, Maria H Vidotti, Paulo Leães, Roberto Botelho, Sérgio Kaiser, Euler Roberto Fernandes Manenti, Dalton Bertolim Précoma, José Carlos Moura Jorge, Pedro G. Silva, José Alexandre Silveira, Wladmir Saporito, José Antônio Marin‐Neto, Gílson Soares Feitosa, Luiz Eduardo Fonteles Ritt, Juliana A. de Souza, Fernando Costa, Weimar K.S.B. Souza, Helder J.L. Reis, Leandro Machado, José Carlos Aidar Ayoub, Georgi V Todorov, Fedya Nikolov, Elena S Velcheva, M. Tzekova, Haralambi O Benov,
OBJECTIVE In observational data, lower levels of lipoprotein(a) have been associated with greater prevalence of type 2 diabetes. Whether pharmacologic lowering of lipoprotein(a) influences incident type 2 diabetes is unknown. We determined the relationship of lipoprotein(a) concentration with incident type 2 diabetes and effects of treatment with alirocumab, a PCSK9 inhibitor. RESEARCH DESIGN AND METHODS In the ODYSSEY OUTCOMES trial alirocumab was compared with placebo in patients with acute coronary ...
American Diabetes Association
Emil Hagström, Philippe Gabríel Steg, Michael Szarek, Deepak L. Bhatt, Vera Bittner, Nicolas Danchin, Rafael Díaz, Shaun G. Goodman, Robert A. Harrington, J. Wouter Jukema, Evangelos Liberopoulos, Nikolaus Marx, Jennifer McGinniss, Garen Manvelian, Robert Pordy, Michel Scemama, Harvey D. White, Andreas M. Zeiher, Gregory G. Schwartz, Gregory G. Schwartz, Deepak L. Bhatt, Vera Bittner, Rafael Díaz, Shaun G. Goodman, Robert A. Harrington, J. Wouter Jukema, Michael Szarek, Harvey D. White, Andreas M. Zeiher, Pierluigi Tricoci, Matthew T. Roe, Kenneth W. Mahaffey, Jay M. Edelberg, Corinne Hanotin, Guillaume Lecorps, Angèle Moryusef, Robert Pordy, William J. Sasiela, Jean‐François Tamby, Rafael Díaz, Philip E Aylward, Heinz Drexel, Peter Sinnaeve, Mirza Dilić, Renato D. Lópes, Nina N Gotcheva, Shaun G. Goodman, Juan Carlos Prieto, Huo Yong, Patricio López‐Jaramillo, Ivan Pećin, Zeljko Reiner, Petr Ostadal, Steen Hvitfeldt Poulsen, Margus Viigimaa, Markku S Nieminen, Nicolas Danchin, Vakhtang Chumburidze, Nikolaus Marx, Evangelos Liberopoulos, Pablo Carlos, Montenegro Valdovinos, Hung‐Fat Tse, Róbert Gábor Kiss, Denis Xavier, Doron Zahger, Marco Valgimigli, Takeshi Kimura, Hyo-Soo Kim, Sang‐Hyun Kim, Andrejs Ērglis, Aleksandras Laucevičius, Saško Kedev, Khalid Yusoff, Gabriel Arturo Ramos López, Marco Alings, Harvey D. White, Sigrun Halvorsen, Roger M Correa Flores, Rody G. Sy, Andrzej Budaj, João Morais, Maria Dorobantu, Yuri Karpov, Arsen Ristić, Terrance Chua, Ján Murín, Zlatko Fras, Anthony J. Dalby, José Tuñón, H. Asita de Silva, Emil Hagström, Ulf Landmesser, Christian Müller, Chern‐En Chiang, Piyamitr Sritara, Sema Güneri, Alexander Parkhomenko, Kausik K. Ray, Patrick M. Moriarty, Matthew T. Roe, Robert A. Vogel, Bernard Chaitman, Sheryl F. Kelsey, Anders Olsson, Jean-Lucien Rouleau, Maarten L. Simoons, Karen Alexander, Chiara Meloni, Robert Rosenson, Eric J.G. Sijbrands, Pierluigi Tricoci, John H. Alexander, Luciana Armaganijan, Akshay Bagai, Maria Cecilia Bahit, J. Matthew Brennan, Shaun Clifton, Adam D. DeVore, Shalonda Deloatch, Sheila Dickey, Keith Dombrowski, Grégory Ducrocq, Zubin J. Eapen, Patricia Endsley, Arleen Eppinger, Robert W. Harrison, Connie Ng Hess, Mark A. Hlatky, J. Dedrick Jordan, Joshua W. Knowles, Brad J. Kolls, David F. Kong, Sergio Leonardi, Linda Lillis, Renato D. Lópes, David J. Maron, Kenneth W. Mahaffey, Jill Marcus, Robin Mathews, Rajendra H. Mehta, Robert J. Mentz, Humberto Graner Moreira, Chetan B. Patel, Sabrina Bernardez Pereira, Lynn Perkins, Thomas J. Povsic, Etienne Puymirat, Matthew T. Roe, W. Schuyler Jones, Bimal R. Shah, Matthew W. Sherwood, Kenya Stringfellow, Darin Sujjavanich, Mustafa Toma, Charlene Trotter, Sean F.P. van Diepen, Matthew D. Wilson, Andrew T. Yan, Lilia Schiavi, Marcelo Garrido, Andrés F. Alvarisqueta, Sonia A Sassone, Anselmo P Bordonava, Alberto E Alves De Lima, Jorge M. Schmidberg, Ernesto A Duronto, Orlando C. Caruso, Leonardo P Novaretto, Miguel Angel Hominal, Oscar Montaña, Alberto Caccavo, Oscar A. Gomez Vilamajo, Alberto J. Lorenzatti, Luis R Cartasegna, Gustavo A. Paterlini, Ignacio J Mackinnon, Guillermo D. Caime, Philippe Gabríel Steg, Oscar Salomone, Oscar R. Codutti, Horacio O. Jure, Julio Bono, Adrian D. Hrabar, Julio Vallejos, Rodolfo A Ahuad Guerrero, Federico Novoa, Cristian A. Patocchi, Cesar Javier Zaidman, María Elena Giuliano, Ricardo D. Dran, Marisa L. Vico, Gabriela S. Carnero, Pablo N. Guzman, Juan C. Medrano Allende, Daniela F Garcia Brasca, Miguel H Bustamante Labarta, Sebastian Nani, Eduardo DS Blumberg, Hugo Colombo, Alberto Liberman, Victorino Fuentealba, Héctor Luciardi, Gabriel Waisman, Mario A Berli, Ruben O Garcia Duran, Horacio G Cestari, Hugo A Luquez, Jorge A Giordano, Silvia S Saavedra, Gerardo Zapata, Osvaldo Costamagna, Susana C. Llois, J. Waites, Nicholas Collins, Allan Soward, Philip E Aylward, Chris LS Hii, Philip E Aylward, James Shaw, Margaret Arstall, John D. Horowitz, Daniel Ninio, James Frederick Rogers, David Colquhoun, Romulo E Oqueli Flores, Philip Roberts-Thomson, Owen Raffel, Sam J. Lehman, Constantine Aroney, Steven Coverdale, P. Garrahy, Gregory Starmer, Mark Sader, Patrick A. Carroll, Ronald Dick, Robert Zweiker, Uta Hoppe, Heinz Drexel, Kurt Huber, Rudolf Berger, Georg Delle-Karth, Bernhard Frey, Franz Weidinger, Dirk Faes, Kurt Hermans, B. Pirenne, Attilio Leone, E Hoffer, Peter Sinnaeve, Mathias Vrolix, Luc De Wolf, Bart Wollaert, Marc Castadot, Karl Dujardin, Christophe Beauloye, Geert Vervoort, Harry Striekwold, Carl Convens, John Roosen, Emanuele Barbato, Marc J. Claeys, Frank Cools, Ibrahim Terzić, Fahir Barakovic, Zlatko Midzic, Belma Pojskić, Emir Fazlibegovic, Mirza Dilić, Azra Durak-Nalbantić, Mehmed Kulić, Dusko Vulic, Adis Muslibegovic, Boris Goronja, Gilmar Reis, Luciano Fernandes Sousa, José Carlos Nicolau, Flavio E Giorgeto, Ricardo Pereira Silva, Lília Nigro Maia, Rafael Rech, Paulo RF Rossi, Maria José AG Cerqueira, Norberto Duda, Renato Kalil, Adrian Kormann, José Antonio M Abrantes, Pedro Pimentel Filho, Ana Priscila Soggia, Mayler ON de Santos, Fernando Neuenschwander, Luiz Carlos Bodanese, Yorghos L Michalaros, Freddy G. Eliaschewitz, Maria H Vidotti, Paulo Leães,
Background: Apolipoprotein B (apoB) provides an integrated measure of atherogenic risk. Whether apoB levels and apoB lowering hold incremental predictive information on residual risk after acute coronary syndrome beyond that provided by low-density lipoprotein cholesterol is uncertain. Methods: The ODYSSEY OUTCOMES trial (Evaluation of Cardiovascular Outcomes After an Acute Coronary Syndrome During Treatment With Alirocumab) compared the proprotein convertase subtilisin/kexin type 9 inhibitor alirocumab ...
Lippincott Williams & Wilkins
Miguel Ángel Rodríguez García, Ignacio Iglesias-Gárriz, Félix Corral Fernández, Carmen Garrote Coloma, Norberto Alonso‐Orcajo, Luísa Moura Branco, Eugenio Picaño,
Los estudios que evalúan la seguridad de la ecocardiografía de estrés son escasos, con resultados discordantes y de series muy seleccionadas de centros con gran experiencia, difícilmente extrapolables. Conocer la seguridad de las diversas modalidades de ecocardiografía de estrés en nuestro medio. Se analizaron retrospectivamente las complicaciones graves durante los ecocardiogramas de estrés practicadas en 29 hospitales de la península Ibérica, desde el inicio de su actividad hasta septiembre de ...
Tópico(s): Pericarditis and Cardiac Tamponade
2001 - Elsevier BV | Revista Española de Cardiología
Pedro Cepas‐Guillén, Javier Borrego-Rodríguez, Eduardo Flores‐Umanzor, Julio Echarte‐Morales, Andrea Fernandez‐Valledor, Paula Menéndez-Suárez, Sara Vázquez‐Calvo, Norberto Alonso, Jose T. Ortiz‐Pérez, Ander Regueiro, Ignacio Iglesias, Rut Andrea, Mónica Masotti, Armando Pérez de Prado, Salvatore Brugaletta, Julián Bayón-Fernández, Xavier Freixa, Felipe Fernández‐Vázquez, Manel Sabaté,
Although older adults are the fastest-growing age group among cardiovascular patients, nonagenarians with ST-segment elevation myocardial infarction (STEMI) are under-represented in clinical trials. The aims of this study are to analyze the clinical presentation and outcomes of nonagenarian patients presenting with STEMI and to compare in-hospital and 1-year clinical outcomes between those treated with optimal medical treatment alone and those receiving primary percutaneous coronary intervention ( ...
Tópico(s): Cardiac, Anesthesia and Surgical Outcomes
2019 - Elsevier BV | The American Journal of Cardiology
Norberto Alonso‐Orcajo, Francisco Miguel Izquierdo-García, E Simarro,
We present a sudden-death case secondary to a right atrial rupture, occuring as a result of a myocardial infarction with very subtle clinical and electrocardiographical signs. This atrial infarction case illustrates the difficulty of diagnosis and also the serious consequences that can result from this medical condition. We review other potential complications which, in clinical practise, are not always attributed to their true origin.
Tópico(s): Cardiac Arrhythmias and Treatments
1994 - Elsevier BV | International Journal of Cardiology
Armando Pérez de Prado, Felipe Fernández‐Vázquez, J. Carlos Cuellas, Norberto Alonso‐Orcajo, Raúl Carbonell, Cristina Pascual, Cristina Olalla, Alejandro Diego‐Nieto, Antonio De Miguel, Ramón García Calabozo,
The interindividual response to antiplatelet treatment is considerable, with the magnitude of response often related to the appearance of clinical events after elective percutaneous coronary intervention (PCI). We investigated whether platelet aggregation inhibition (PAI) by early administration of abciximab would affect myocardial reperfusion outcomes observed after PCI in patients with acute ST-elevation myocardial infarction (STEMI). Consecutive patients with STEMI who were treated with PCI in our ...
Tópico(s): Cardiac Imaging and Diagnostics
2006 - Elsevier BV | The American Journal of Cardiology
Luis Norberto González Alonso,
Tópico(s): European Union Policy and Governance
2005 - Asociación Española de Profesores de Derecho Internacional y Relaciones Internacionales | Revista Española de Derecho Internacional
Shaun G. Goodman, Philippe Gabríel Steg, Michael Szarek, Deepak L. Bhatt, Vera Bittner, Rafael Díaz, Robert A. Harrington, J. Wouter Jukema, Harvey D. White, Andreas M. Zeiher, Garen Manvelian, Robert Pordy, Yann Poulouin, Wanda Stipek, Geneviève Garon, Gregory G. Schwartz, Gregory G. Schwartz, Philippe Gabríel Steg, Deepak L. Bhatt, Vera Bittner, Rafael Dı́az, Shaun G. Goodman, Robert A. Harrington, J. Wouter Jukema, Michael Szarek, Harvey D. White, Andreas M. Zeiher, Pierluigi Tricoci, Matthew T. Roe, Kenneth W. Mahaffey, Jay M. Edelberg, Corinne Hanotin, Guillaume Lecorps, Angèle Moryusef, Robert Pordy, William J. Sasiela, Jean‐François Tamby, Rafael Dı́az, Philip E. Aylward, Heinz Drexel, Peter Sinnaeve, Mirza Dilić, Renato D. Lópes, Nina Gotcheva, Shaun G. Goodman, Juan Carlos Prieto, Huo Yong, Patricio López‐Jaramillo, Ivan Pećin, Željko Reiner, Petr Ostadal, Steen Hvitfeldt Poulsen, Margus Viigimaa, Markku S. Nieminen, Nicolas Danchin, Vakhtang Chumburidze, Nikolaus Marx, Evangelos Liberopoulos, Pablo Carlos Montenegro Valdovinos, Hung-Fat Tse, Róbert Gábor Kiss, Denis Xavier, Doron Zahger, Marco Valgimigli, Takeshi Kimura, Hyo-Soo Kim, Sang‐Hyun Kim, Andrejs Ērglis, Aleksandras Laucevičius, Sasko Kedev, Khalid Yusoff, Gabriel Arturo Ramos López, Marco Alings, Harvey D. White, Sigrun Halvorsen, R. Correa, Rody G. Sy, Andrzej Budaj, João Morais, Maria Dorobanţu, Yuri Karpov, Arsen Ristić, Terrance Chua, Ján Murín, Zlatko Fras, Anthony J. Dalby, José Tuñón, H Asita de Silva, Emil Hagström, Ulf Landmesser, Chern-En Chiang, Piyamitr Sritara, Sema Güneri, Alexander Parkhomenko, Kausik K. Ray, Patrick M. Moriarty, Bernard Chaitman, Sheryl F. Kelsey, Anders Olsson, Jean‐Lucien Rouleau, Maarten L. Simoons, Karen Alexander, Chiara Meloni, Robert S. Rosenson, Eric J.G. Sijbrands, Pierluigi Tricoci, John H. Alexander, Luciana Armaganijan, J. Dedrick Jordan, Maria Cecilia Bahit, James M. Brennan, Shaun Clifton, Adam D. DeVore, Shalonda Deloatch, Sheila Dickey, Keith Dombrowski, Grégory Ducrocq, Zubin Eapen, Patricia Endsley, Arleen Eppinger, Robert W. Harrison, Connie Ng Hess, Mark A. Hlatky, J. Dedrick Jordan, Joshua W. Knowles, Brad J. Kolls, David F. Kong, Sergio Leonardi, Linda Lillis, Renato D. Lópes, David J. Maron, Kenneth W. Mahaffey, Jill Marcus, Robin Mathews, Rajendra H. Mehta, Robert J. Mentz, Chetan B. Patel, Sabrina Bernardez Pereira, Lynn Perkins, Thomas J. Povsic, Etienne Puymirat, Matthew T. Roe, W. Schuyler Jones, Bimal R. Shah, Matthew W. Sherwood, Kenya Stringfellow, Darin Sujjavanich, Mustafa Toma, Charlene Trotter, Sean F P van Diepen, Matthew D. Wilson, Andrew T. Yan, Lilia Schiavi, Marcelo Garrido, Andrés F. Alvarisqueta, Sonia A Sassone, Anselmo P. Bordonava, Alberto Enrique Alves de Lima, Jorge M. Schmidberg, Ernesto Duronto, Orlando C. Caruso, Leonardo P. Novaretto, Miguel Angel Hominal, Oscar Montaña, Alberto Caccavo, Oscar A. Gomez Vilamajo, Alberto J. Lorenzatti, Luis Cartasegna, Gustavo A. Paterlini, Ignacio MacKinnon, Guillermo D. Caime, Philippe Gabríel Steg, Oscar Salomone, Oscar R. Codutti, Horacio O. Jure, Julio O.E. Bono, Adrian D. Hrabar, Julio Vallejos, Rodolfo A. Ahuad Guerrero, Federico Novoa, Cristian A. Patocchi, Cesar Javier Zaidman, María Elena Giuliano, Ricardo D. Dran, Marisa L. Vico, Gabriela S. Carnero, Pablo N. Guzman, Juan C. Medrano Allende, Daniela F. Garcia Brasca, Miguel H Bustamante Labarta, S Nani, Eduardo D.S. Blumberg, Hugo Colombo, Alberto Liberman, Victorino Fuentealba, Héctor Luciardi, Gabriel Waisman, Mario A Berli, Ruben O Garcia Duran, Horacio G Cestari, Hugo A Luquez, Jorge A Giordano, Silvia S Saavedra, Gerardo Zapata, Osvaldo Costamagna, Susana Llois, J. Waites, Nicholas Collins, Allan Soward, Philip E. Aylward, Chris L.S. Hii, Philip E. Aylward, James Shaw, Margaret Arstall, John D. Horowitz, Daniel Ninio, James Frederick Rogers, David Colquhoun, Romulo E Oqueli Flores, Philip Roberts-Thomson, Owen Raffel, Sam J. Lehman, Constantine Aroney, Steven G M Coverdale, P. Garrahy, G. Starmer, Mark Sader, Patrick A. Carroll, Ronald Dick, Robert Zweiker, Uta Hoppe, Heinz Drexel, Kurt Huber, Rudolf Berger, Georg Delle-Karth, Bernhard Frey, Dirk Faes, Kurt Hermans, B. Pirenne, Attilio Leone, E Hoffer, Peter Sinnaeve, Mathias C.M. Vrolix, Luc De Wolf, Bart Wollaert, Marc Castadot, Karl Dujardin, Christophe Beauloye, Geert Vervoort, Harry Striekwold, Carl Convens, John Roosen, Emanuele Barbato, Marc J. Claeys, Frank Cools, Ibrahim Terzić, Fahir Baraković, Zlatko Midzic, Belma Pojskić, Emir Fazlibegovic, Mirza Dilić, Azra Durak-Nalbantic, Mehmed Kulić, Dusko Vulic, Adis Muslibegovic, Boris Goronja, Gilmar Reis, Luciano Fernandes Sousa, José Carlos Nicolau, Flavio E Giorgeto, Ricardo Pereira Silva, Lília Nigro Maia, Rafael Rech, Paulo RF Rossi, Maria José AG Cerqueira, Norberto Duda, Renato Kalil, Adrian Kormann, José Antonio M Abrantes, Pedro Pimentel Filho, Ana Priscila Soggia, Mayler O.N. de Santos, Fernando Neuenschwander, Luiz Carlos Bodanese, Yorghos L Michalaros, Freddy G. Eliaschewitz, Maria H Vidotti, Paulo Leães, Roberto Botelho, Sérgio Kaiser, Euler Roberto Fernandes Manenti, Dalton Bertolim Précoma, José Carlos Moura Jorge, Pedro Silva, José Alexandre Silveira, Wladmir Faustino Saporito,
The ODYSSEY OUTCOMES trial, comprising over 47 000 patient-years of placebo-controlled observation, demonstrated important reductions in the risk of recurrent ischaemic cardiovascular events with the monoclonal antibody to proprotein convertase subtilisin/kexin type 9 alirocumab, as well as lower all-cause death. These benefits were observed in the context of substantial and persistent lowering of low-density lipoprotein cholesterol with alirocumab compared with that achieved with placebo. The safety ...
Oxford University Press
Enrique M. San Norberto, Daniel Gómez-Alonso, José M. Trigueros, Jorge Quiroga, Javier Gualis, Carlos Vaquero,
Evaluar la legibilidad de los documentos de consentimiento informado (CI) de las diferentes sociedades nacionales quirúrgicas. Durante enero de 2012 se recogieron los 504 protocolos de CI de las diferentes especialidades. Para el cálculo de legibilidad se valoraron los parámetros: número de palabras, sílabas y frases, promedio sílabas/palabra y palabras/frase, índice de correlación Word, índice de Flesch-Szigriszt, índice de Fernández-Huerta, grado en la escala Inflesz y el índice de Gunning-Fog. ...
Tópico(s): Ethics in Clinical Research
2013 - Elsevier BV | Cirugía Española
Enrique M. San Norberto, Daniel Gómez-Alonso, José M. Trigueros, Jorge Quiroga, Javier Gualis, Carlos Vaquero,
To assess the readability of informed consent (IC) documents of the different national surgical societies. During January 2012 we collected 504 IC protocols of different specialties. To calculate readability parameters the following criteria were assessed: number of words, syllables and phrases; syllables/word and word/phrase; averages; Word correlation index; the Flesch-Szigriszt index; Fernández-Huerta index; the Inflesz scale degree and the Gunning Fog index. The mean Flesch-Szigriszt index was ...
Tópico(s): Ethics and bioethics in healthcare
2014 - Elsevier BV | Cirugía Española (English Edition)
Michael E. Pichichero, Ángela Gentile, Norberto Giglio, Margarita Martin Alonso, Maria Veronica Fernandez Mentaberri, Grażyna Zaręba, Thomas W. Clarkson, C Gotelli, Mariano Gotelli, Lihan Yan, John J. Treanor,
Objective We conducted a population-based pharmacokinetic study to assess blood levels and elimination of mercury after vaccination of premature infants born at ≥32 and <37 weeks of gestation and with birth weight ≥2000 but <3000 g. Study design Blood, stool, and urine samples were obtained before vaccination and 12 hours to 30 days after vaccination from 72 premature newborn infants. Total mercury levels were measured by atomic absorption. Results The mean ± standard deviation (SD) birth weight was 2. ...
Tópico(s): Prenatal Substance Exposure Effects
2009 - Elsevier BV | The Journal of Pediatrics
María Isabel Peralta‐Ramírez, Maria Angeles Coín-Mejias, J Jiménez-Alonso, Norberto Ortego‐Centeno, José Luis Callejas‐Rubio, Alfonso Caracuel, Miguel Pérez-Garcı́a,
The objective of this study was to investigate the possible effects of the daily stress experienced during a six-month period on the cognitive functioning of patients with systemic lupus erythematosus (SLE). For this purpose, we evaluated the daily stress of 21 patients with lupus every day for six months. Later, we carried out a neuropsychological exam that included an evaluation of attention and memory. At the same time, scores on depression and anxiety were recorded with the objective of controlling ...
Tópico(s): Sphingolipid Metabolism and Signaling
2006 - SAGE Publishing | Lupus
Produção Nacional
Revisado por pares
Márcio Flávio Dutra Moraes, Orfa Yineth Galvis‐Alonso, Norberto Garcia‐Cairasco,
Repetitive high intensity (110 dB) sound stimulation induces a forebrain-kindling phenomenon in animals predisposed to sound induced seizures. Wistar audiogenic rats (WARs) have been reported to develop a mixed brainstem-limbic seizure pattern, after more than five to ten stimuli. Besides the original brainstem wild running and tonic-clonic seizures, new behavioral patterns appear resembling those of electrical amygdala kindling. Although audiogenic kindling is a well-known phenomenon, electrographic ...
Tópico(s): Neuroscience and Neuropharmacology Research
2000 - Elsevier BV | Epilepsy Research
Pedro Carriere, Natalia Calvo, María Belén Novoa Díaz, Fernanda López‐Moncada, Alexander Herrera, Marı́a José Torres, Exequiel G. Alonso, Norberto A. Gandini, Graciela Gigola, Héctor R. Contreras, Claudia Gentili,
Tópico(s): Oral and Maxillofacial Pathology
2021 - Elsevier BV | Molecular and Cellular Endocrinology
Armando Pérez de Prado, Carlos Cuellas, Alejandro Diego‐Nieto, Antonio De Miguel, Beatriz Samaniego, Norberto Alonso‐Orcajo, Raúl Carbonell, Cristina Pascual, Felipe Fernández‐Vázquez, Ramón García Calabozo,
Introduction A wide variability in the response to clopidogrel and magnitude of post-treatment platelet reactivity has been described. However, this has been demonstrated by light transmittance aggregometry, a method too laborious for daily practice. Point-of-care devices may overcome this limitation, but little is known on the predictive value of such measurements. Our objective was to determine the relationship between platelet reactivity and the incidence of myocardial damage following percutaneous ...
Tópico(s): Coronary Interventions and Diagnostics
2009 - Elsevier BV | Thrombosis Research
Alejandro Diego‐Nieto, María‐Belén Vidriales, Norberto Alonso‐Orcajo, José Carlos Moreno-Samos, Francisco Martín‐Herrero, Raúl Carbonell, Belén Cid, Ignacio Cruz‐González, Javier Martín‐Moreiras, Carlos Cuellas, Cristina Pascual, María López-Benito, Pedro L. Sánchez, Felipe Fernández‐Vázquez, Armando Pérez de Prado,
Background Ticagrelor use during acute coronary syndromes demonstrated a decrease in all-cause mortality in the PLATO (Platelet Inhibition and Patient Outcomes) trial. This effect has been attributed to a non-platelet-derived improvement in endothelial function. The aim of this study was to determine differences in the number of endothelial progenitor cells and/or circulating endothelial cells found in peripheral blood in patients treated with either ticagrelor or clopidogrel during non-ST-segment- ...
Tópico(s): Acute Myocardial Infarction Research
2018 - Wiley | Journal of the American Heart Association
Michael R. Narkewicz, Simon Horslen, Regina M. Hardison, Benjamin L. Shneider, Norberto Rodriguez‐Baez, Estella M. Alonso, Vicky L. Ng, Mike A. Leonis, Kathleen M. Loomes, David A. Rudnick, Philip Rosenthal, René Romero, Girish Subbarao, Ruosha Li, Steven H. Belle, Robert H. Squires, Robert H. Squires, Kathryn Bukauskas, Madeline Schulte, Michael R. Narkewicz, Michelle Hite, Kathleen M. Loomes, Elizabeth B. Rand, David A. Piccoli, Deborah A. Kawchak, Christa Seidman, René Romero, Saul J. Karpen, Liezl de la Cruz-Tracy, Vicky L. Ng, Kelsey Hunt, Girish Subbarao, Ann Klipsch, Sarah Munson, Estella M. Alonso, Lisa Sorenson, Susan Kelly, Katie Neighbors, Philip Rosenthal, Shannon Fleck, Mike A. Leonis, John C. Bucuvalas, Tracie Horning, Norberto Rodriguez Baez, Shirley Montanye, Martín Cowie, Simon Horslen, Karen F. Murray, Melissa Young, Heather Nielson, Jani Klein, David A. Rudnick, Ross W. Shepherd, Kathy Harris, Saul J. Karpen, Alejandro de la Torre, Dominic Dell Olio, Déirdre Kelly, Carla Lloyd, Steven J. Lobritto, Sumerah Bakhsh, Maureen M. Jonas, Scott A. Elifoson, Roshan Raza, Kathleen B. Schwarz, Wikrom Karnsakul, Mary Kay Alford, Anil Dhawan, Emer Fitzpatrick, Benjamin L. Shneider, Nanda Kerkar, Brandy Haydel, Sreevidya Narayanappa, M. James Lopez, Victoria Shieck, Edward Doo, Averell H. Sherker, Steven H. Belle,
Background & Aims Many pediatric patients with acute liver failure (PALF) do not receive a specific diagnosis (such as herpes simplex virus or Wilson disease or fatty acid oxidation defects)—they are left with an indeterminate diagnosis and are more likely to undergo liver transplantation, which is contraindicated for some disorders. Strategies to facilitate complete diagnostic testing should increase identification of specific liver diseases and might reduce liver transplantation. We investigated whether performing ...
Tópico(s): Sepsis Diagnosis and Treatment
2018 - Elsevier BV | Clinical Gastroenterology and Hepatology
Elena Sánchez, Rogelio Palomino‐Morales, Norberto Ortego‐Centeno, J Jiménez-Alonso, Miguel Á. González‐Gay, Miguel Ángel López‐Nevot, Julio Sánchez-Román, Enrique de Ramón, M.F. González‐Escribano, Bernardo A. Pons‐Estel, Sandra D’Alfonso, Gian Domenico Sebastiani, Marta E. Alarcón‐Riquelme, Javier Martı́n,
Interleukin-18 (IL-18) is a proinflammatory cytokine that plays an important role in chronic inflammation and autoimmune disorders. In this study, we aimed to determine the potential role of the IL18 gene in SLE. To define the genetic association of the IL18 and SLE, we have genotyped nine SNPs in an independent set of Spanish cases and controls. The IL18 polymorphisms were genotyped by PCR, using a predeveloped TaqMan allele discrimination assay. Two SNPs were still significant after fine mapping ...
Tópico(s): Systemic Lupus Erythematosus Research
2009 - Oxford University Press | Human Molecular Genetics
Gamze Kabalak, Rachel Thomas, Javier Martı́n, Norberto Ortego‐Centeno, J Jiménez-Alonso, Enrique de Ramón, Sabine Buyny, Sandra Hamsen, Wolfgang L. Gross, S. Schnarr, H. Zeidler, Erika Gromnica‐Ihle, Reinhold Schmidt, Torsten Witte,
NKG2D, involved in T-cell activation and viral defense, shows a single-nucleotide polymorphism (SNP) in the transmembrane region, characterized by a substitution of alanine with threonine. We examined the association of systemic lupus erythematosus (SLE) with one of the NKG2D gene variants. We also studied the functional impact of that allele in SLE. Restriction fragment length polymorphism/polymerase chain reaction specific for the SNP rs2255336 G→ A was performed with 247 German SLE patients and ...
Tópico(s): IL-33, ST2, and ILC Pathways
2009 - Elsevier BV | Human Immunology
Elena Sánchez, Behrooz Z. Alizadeh, Gustavo Valdigem, Norberto Ortego‐Centeno, J Jiménez-Alonso, Enrique de Ramón, Antonio Delgado, Miguel Ángel López‐Nevot, Cisca Wijmenga, Javier Martı́n, Bobby P. C. Koeleman,
The aim of the study was to test MYO9B gene polymorphisms for association with three autoimmune diseases, systemic lupus erythematosus (SLE), rheumatoid arthritis (RA), and celiac disease (CD), in a Spanish population. We analyzed three SNPs (rs2305767, rs1457092, and rs2305764) in a case–control cohort composed of 349 SLE patients, 356 RA patients, 90 CD patients, and 345 healthy controls. All three SNPs showed a consistent increased frequency of the A allele in SLE, RA, and CD patients compared with ...
Tópico(s): Immunodeficiency and Autoimmune Disorders
2007 - Elsevier BV | Human Immunology
Elena Sánchez, Blanca Rueda‐Medina, José Luis Callejas‐Rubio, José Mario Sabio, Norberto Ortego‐Centeno, J Jiménez-Alonso, Miguel Ángel López‐Nevot, Javier Martı́n,
Abstract The aim of this study was to evaluate the association between systemic lupus erythematosus (SLE) and polymorphisms in the interleukin‐23 receptor ( IL23R ) gene, which have been previously found to be associated with two autoimmune diseases: inflammatory bowel disease and psoriasis. Our study includes 224 SLE patients and 342 healthy controls. The genotyping of IL23R variants was carried out using a polymerase chain reaction system with predeveloped TaqMan allelic discrimination assays. No statistically ...
Tópico(s): Psoriasis: Treatment and Pathogenesis
2007 - Wiley | Tissue Antigens
Elena Sánchez, Anna-Karin Abelson, José Mario Sabio, Miguel Á. González‐Gay, Norberto Ortego‐Centeno, J Jiménez-Alonso, Enrique de Ramón, Julio Sánchez-Román, Miguel Ángel López‐Nevot, Iva Gunnarsson, Elisabet Svenungsson, Gunnar Sturfelt, Lennart Truedsson, Andreas Jönsen, M.F. González‐Escribano, Torsten Witte, Marta E. Alarcón‐Riquelme, Javier Martı́n,
Abstract Objective To determine the potential role of the CD24 A57V gene polymorphism in systemic lupus erythematosus (SLE). Methods We studied 3 cohorts of Caucasian patients and controls. The Spanish cohort included 696 SLE patients and 539 controls, the German cohort included 257 SLE patients and 317 controls, and the Swedish cohort included 310 SLE patients and 247 controls. The CD24 A57V polymorphism was genotyped by polymerase chain reaction, using a predeveloped TaqMan allele discrimination ...
Tópico(s): Immune Cell Function and Interaction
2007 - Wiley | Arthritis & Rheumatism
Elena Sánchez, Belén Torres, J. R. Vilches, Miguel Ángel López‐Nevot, Norberto Ortego‐Centeno, J Jiménez-Alonso, Miguel Á. González‐Gay, Enrique de Ramón, J Sánchez-Román, Antonio Núñez‐Roldán, Javier Martı́n, Marı́a-Francisca González-Escribano,
Objective. To replicate the described association between MHC class I chain-related A (MICA) gene polymorphism and susceptibility to systemic lupus erythematosus (SLE). Methods. MICA transmembrane microsatellite polymorphism was genotyped using a polymerase chain reaction (PCR)-based method. Genotyping of HLA-B* and DRB1* was performed using PCR and detection with a reverse sequence-specific oligonucleotide (SSO) probe system. Combined data for these three loci (HLA-B*, DRB1* and MICA) were obtained ...
Tópico(s): Systemic Lupus Erythematosus Research
2006 - Oxford University Press | Lara D. Veeken
Gisela Orozco, Elena Sánchez, Miguel Á. González‐Gay, Miguel Ángel López‐Nevot, Belén Torres, Rafael Cáliz, Norberto Ortego‐Centeno, J Jiménez-Alonso, Dora Pascual‐Salcedo, Alejandro Balsa, Rosario de Pablo, Antonio Núñez‐Roldán, Ma Francisca González‐Escribano, Javier Martı́n,
Abstract Objective To assess the possible association between the PTPN22 gene 1858C→T polymorphism and the predisposition and clinical expression of 2 systemic autoimmune diseases, rheumatoid arthritis (RA) and systemic lupus erythematosus (SLE). Methods Our study population consisted of 826 RA patients, 338 SLE patients, and 1,036 healthy subjects. All subjects were of Spanish Caucasian origin. Genotyping of the PTPN22 gene 1858C→T polymorphism was performed by real‐time polymerase chain reaction ...
Tópico(s): Galectins and Cancer Biology
2005 - Wiley | Arthritis & Rheumatism
Gorka Urbikaín, Francisco J. Campa, J.J. Zulaika, Luís Norberto López de Lacalle, Miguel Alonso, Valentín Collado,
Productivity and surface finish are typical user manufacturer requirements that are restrained by chatter vibrations sooner or later in every machining operation. Thus, manufacturers are interested in knowing, before building the machine, the dynamic behaviour of each machine structure with respect to another. Stability lobe graphs are the most reliable approach to analyse the dynamic performance. During heavy rough turning operations a model containing (a) several modes, or (b) modes with non-conventional ( ...
Tópico(s): Advanced Measurement and Metrology Techniques
2014 - Elsevier BV | Journal of Sound and Vibration
Daniel Krähmer, R. Polvorosa, Luís Norberto López de Lacalle, Unai Alonso, Germán Abate, F. Riu,
Tópico(s): Erosion and Abrasive Machining
2016 - Springer Science+Business Media | Experimental Techniques
Norberto A. Gandini, Eliana Noelia Alonso, María Eugenia Fermento, Marilina Mascaró, Martı́n C. Abba, Georgina P. Coló, Julián Arévalo, María Julia Ferronato, Josefina Alejandra Guevara, Myriam Núñez, Pamela Pichel, Alejandro C. Curino, María M. Facchinetti,
Aims: Heme oxygenase-1 (HO-1) is an enzyme involved in cellular responses to oxidative stress and has also been shown to regulate processes related to cancer progression. In this regard, HO-1 has been shown to display a dual effect with either antitumor or protumor activity, which is also true for breast cancer (BC). In this work, we address this discrepancy regarding the role of HO-1 in BC. Results: HO-1 was detected in human BC tissues, and its protein levels correlated with reduced tumor size and ...
Tópico(s): High Altitude and Hypoxia
2018 - Mary Ann Liebert, Inc. | Antioxidants and Redox Signaling
Enrique M. San Norberto, Daniel Gómez-Alonso, José M. Trigueros, Jorge Quiroga, Javier Gualis, Carlos Vaquero,
Tópico(s): Digital Imaging in Medicine
2012 - Elsevier BV | Angiología
Elena Sánchez, José Mario Sabio, José Luis Callejas‐Rubio, Enrique de Ramón, M. de Haro, J Jiménez-Alonso, Norberto Ortego‐Centeno, J Sánchez-Román, Miguel Á. González‐Gay, Miguel Ángel López‐Nevot, M.F. González‐Escribano, Javier Martı́n,
The aim of this study was to assess the possible association between the p53 suppressor gene codon 72 polymorphism and systemic lupus erythematosus (SLE). Our study population consisted of 513 SLE patients and 567 healthy controls. All the individuals were of Spanish Caucasian origin. Genotyping of the p53 codon 72 polymorphism was performed by allele-specific PCR. No statistically significant differences were observed between SLE patients and healthy controls when p53 codon 72 genotype and allele ...
Tópico(s): Protein Tyrosine Phosphatases
2006 - SAGE Publishing | Lupus