Lauralicia Sacre, S. Mohd Ali, Antoine Villa, Romain Jouffroy, Jean‐Herlé Raphalen, R. Garnier, Frédéric J. Baud,
... des mono-intoxications à l'oxazépam et au nordazépam. Les cas de mono-intoxications à l'oxazépam et au nordazépam collectés au centre antipoison de Paris de 1999 ... de mono-intoxications à l'oxazépam et au nordazépam ont été inclus, respectivement. L'Emax observé pour l'oxazépam et le nordazépam était somnolence/obnubilation survenant dans 106 et 36 ... 26,7 fois la dose recommandée pour le nordazépam et l'oxazépam. L'IT du patient ayant ... de paramètres toxicodynétiques. La toxicodynétique montre que le nordazépam, même à très forte dose, n'induit pas ...
Tópico(s): Drug-Induced Hepatotoxicity and Protection
2017 - Elsevier BV | Annales Pharmaceutiques Françaises
Thomas Stebler, T. W. Guentert,
... chromatographic assay was developed to quantitate diazepam and nordazepam in the milk and plasma of humans and ... was for diazepam 20 ng/ml and for nordazepam 15 ng/ml. The absolute recoveries of diazepam, nordazepam and flurazepam in human milk were 84, 86 ... between-day accuracy and precision for diazepam and nordazepam in milk and plasma at all concentrations tested ( ... monitor milk and plasma concentrations of diazepam and nordazepam in lactating New Zealand White rabbits during 26- ...
Tópico(s): Neuroendocrine regulation and behavior
1991 - Elsevier BV | Journal of Chromatography B Biomedical Sciences and Applications
Mahsa Torabizadeh, Zahra Talebpour, Nuoshin Adib, Hassan Y. Aboul‐Enein,
... detection for the simultaneous determination of diazepam and nordazepam in human plasma samples. To optimize the extraction ... ranges for diazepam (36-1200 ng/mL) and nordazepam (25-1200 ng/mL), with correlation coefficients of ... successfully applied to the analysis of diazepam and nordazepam at their therapeutic levels in human plasma. The ... simultaneous extraction of diazepam and its active metabolite, nordazepam in human plasma sample. The method was more ... similar methods for the determination of diazepam and nordazepam in biological fluids.
Tópico(s): Analytical Methods in Pharmaceuticals
2016 - Wiley | Journal of Separation Science
Sofia Valenti, Marı́a Barrio, P. Négrier, Michela Romanini, Roberto Macovez, J. Ll. Tamarit,
... of almost same molecular mass and structure (Diazepam, Nordazepam and Tetrazepam) were chosen as model compounds. Nordazepam is the only one that displays N-H··· ... motion appears to be largely hindered in glassy Nordazepam, possibly due to the presence of the hydrogen bonds. Supercooled liquid Tetrazepam and Nordazepam are observed to crystallize into their stable crystalline ... and thus of the structural relaxation time, with Nordazepam displaying slower growth kinetics. Diazepam does not instead ...
Tópico(s): Crystallization and Solubility Studies
2021 - American Chemical Society | Molecular Pharmaceutics
A. El Moussaoui, Alain Chauvet, Jacques Massé,
We have determined the eutectic composition nordazépam (NDZ) polyoxyethylene glycol 6000 (PEG): 4% NDZ, 96% PEG (T f =59,0±0,5°C ΔH f=155,9±2,4 ... X-ray diffraction. Folgende eutektische Zusammensetzungen wurden bestimmt: Nordazepam (NDZ) Polyoxyethylenglykol 6000 (PEG): 4% NDZ, 96% PEG ( ...
Tópico(s): Drug Solubulity and Delivery Systems
1993 - | Journal of thermal analysis
Helen Archontaki, Evagelos Gikas, Irene Panderi, P.M. Ovezikoglou,
... developed to study the acid-catalysed hydrolysis of nordazepam in hydrochloric acid solutions of 0.01, 0. ... 5% for the derivative method. Detection limits for nordazepam, intermediate and final degradation product were 1.8× ... method and 7.0×10−7 M for nordazepam in the latter. Estimation of k1, k−1 ...
Tópico(s): Neuroscience and Neuropharmacology Research
1998 - Elsevier BV | International Journal of Pharmaceutics
P.E.B. Reilly, Diane Thompson, Steven R. Mason, W. D. Hooper,
... and temazepam and C3-hydroxylation of diazepam and nordazepam. Both C3-hydroxylation reactions were more rapid in ... that the adjacent methyl N-substituent (absent in nordazepam but present in diazepam) did not affect the ...
Tópico(s): Neurotransmitter Receptor Influence on Behavior
1990 - American Society for Pharmacology and Experimental Therapeutics | Molecular Pharmacology
Saïd Kinani, Stéphane Bouchonnet, Nathalie Milan, Ivan Ricordel,
... tandem mass spectrometry method for detection of diazepam, nordazepam and oxazepam is presented. The method associates electron ... to provide two product ions for diazepam and nordazepam and one product ion for the decomposition product ... mL for diazepam, 1.0 ng/mL for nordazepam and 1.5 ng/mL for oxazepam. Mechanisms ...
Tópico(s): Molecular Sensors and Ion Detection
2006 - Elsevier BV | Journal of Chromatography A
I. Carpinteiro, Rosario Rodil, José Benito Quintana, R. Cela,
... work, the reaction of four benzodiazepines (diazepam, oxazepam, nordazepam and temazepam) during water chlorination was studied by ... a significant degradation, i.e. diazepam, oxazepam and nordazepam, parameters affecting to the reaction kinetics (pH, chlorine ... h and 2.5–637 h for oxazepam, nordazepam and diazepam, respectively, depending of the levels of ...
Tópico(s): Analytical chemistry methods development
2017 - Elsevier BV | Water Research
Yunfang Zhou, Deru Meng, Feifei Chen, Zhengping Wu, Binglan Wang, Shuanghu Wang, Peiwu Geng, Da‐Peng Dai, Quan Zhou, Weiwen Qiu,
... of CYP450. The IC50 values of imperatorin to nordazepam and temazepam were 1.54 μM and 1. ... respectively. The inhibitory constant values for temazepam and nordazepam were 1.24 μM and 1.29 μM, ... AUC(0-12h), AUC(0-∞), and Cmax of nordazepam and temazepam decreased significantly, and Vz/F and ...
Tópico(s): Plant chemical constituents analysis
2020 - Frontiers Media | Frontiers in Pharmacology
George A. Neville, H. F. Shurvell,
... R) at N‐1. The five compounds are nordazepam (R H), diazepam (R CH 3 ), pinazepam (R ... structure and the substituent groups. The spectra of nordazepam suggest that the compound exists as a centrosymmetric ...
Tópico(s): Analytical Methods in Pharmaceuticals
1990 - Wiley | Journal of Raman Spectroscopy
Ning Yue, Linhai Wu, Lie Li, Chuanlai Xu,
... clonazepam, 7-aminonitrazepam, 7-amidoclonzepam, chlordiazepoxide, delorazepam and nordazepam. Class selective artificial antigens were prepared by haptens ... nitrazepam, clonazepam, 7-aminonitrazepam, 7-aminoclonazepam, delorazepam and nordazepam, respectively. Assay performance was validated using spiked pig ...
Tópico(s): Analytical chemistry methods development
2009 - Taylor & Francis | Food and Agricultural Immunology
Hironobu Umezawa, Xiao‐Pen Lee, Yoshiko Arima, Chika Hasegawa, Akemi Marumo, Takeshi Kumazawa, Keizo Sato,
Abstract Diazepam and its major metabolites, nordazepam, temazepam and oxazepam, in human urine samples, were analyzed by liquid chromatography (LC)/tandem mass spectrometry (MS/MS) using a hydrophilic polymer ... determination of diazepam and its three metabolites, oxazepam, nordazepam and temazepam, in human urine after oral administration ...
Tópico(s): Analytical Methods in Pharmaceuticals
2008 - Wiley | Rapid Communications in Mass Spectrometry
Salvatore Millefiori, Andrea Alparone,
Vertical ionization energies (VIEs) of medazepam, nordazepam and their molecular subunits have been calculated using the electron propagator method in the P3/CEP-31G* approximation. Vertical electron affinities (VEAs) ... less hard (i.e., less stable) compound than nordazepam.
Tópico(s): Molecular Junctions and Nanostructures
2010 - Springer Science+Business Media | Journal of Molecular Modeling
Nathalie Cartiser, Fabien Bévalot, C. Le Meur, Yvan Gaillard, Daniel Malicier, N. Hubert, Jérôme Guitton,
... order to quantify citalopram and 4 benzodiazepines (diazepam, nordazepam, oxazepam and temazepam) in 11 biological matrices (blood, ... of the method was 1 ng/g for nordazepam, 5 ng/g for citalopram and 10 ng/ ...
Tópico(s): Analytical Chemistry and Chromatography
2011 - Elsevier BV | Journal of Chromatography B
Frank T. Peters, Julia Jung, Thomas Kræmer, Hans H. Maurer,
... includes relevant analytes (thiopental, pentobarbital, methohexital, phenobarbital, diazepam, nordazepam, and midazolam) and proposes limits of quantification. Propofol ... 05-2.5 mg/L for diazepam and nordazepam, and 0.01-0.5 mg/L for ...
Tópico(s): Anesthesia and Sedative Agents
2005 - Lippincott Williams & Wilkins | Therapeutic Drug Monitoring
Hermı́nio P. Diogo, Joaquim J. Moura Ramos,
... glass transformation region of two compounds, diazepam and nordazepam; these are two benzodiazepines, a family of psychotropic ...
Tópico(s): Thermodynamic properties of mixtures
2022 - Elsevier BV | Journal of Pharmaceutical Sciences
Alain Chauvet, Abdelghani Moussaoui, Jacques Massé,
... and spectral behaviour of benzodiazepines we have studied nordazepam. After crystallization in various solvents at different temperatures ... us to characterize the polymorphism and pseudopolymorphism of nordazepam. We have obtained form I after transition at ... kJ mol−1) and a solvate (5-1) nordazepam-dioxane. Poursuivant l'étude thermoanalytique et spectrale de benzodiazépines nous nous sommes intéressés au nordazépam. Après recristallisation dans divers solvants et à différentes ... de déceler le polymorphisme et le pseudopolymorphisme du nordazépam. Nous avons obtenu la forme I après transformation ...
Tópico(s): Crystallization and Solubility Studies
1992 - Elsevier BV | Thermochimica Acta
Lele Wang, Xinxin Ren, Yi He, Guan-feng Cui, Zhiwen Wei, Keming Yun,
... chromatography-tandem mass spectrometry method, and diazepam and nordazepam were detected in the oral fluid of volunteers. ... 68.5, 12.1 ± 11.6 h, respectively, nordazepam conformed to an one-compartment model, and k01_ ... 3 ± 365.5 h, respectively. Both diazepam and nordazepam could be detected continuously for 15 days, although ...
Tópico(s): Epilepsy research and treatment
2020 - Oxford University Press | Journal of Analytical Toxicology
Sofia Valenti, Claudio Cazorla, Michela Romanini, J. Ll. Tamarit, Roberto Macovez,
... of two commercial active pharmaceutical ingredients, diazepam and nordazepam, of which the latter, besides being administered as ... eutectic composition of 0.18 molar fraction of nordazepam, with a eutectic melting point of Te = 395. ... onset of thermal decomposition of either compound (pure nordazepam decomposes upon melting and pure diazepam well above ...
Tópico(s): Thermodynamic properties of mixtures
2023 - Multidisciplinary Digital Publishing Institute | Pharmaceutics
Z. J. Vejdělek, M. Rajšner, A Dlabac, Miroslav Ryska, J. HOLUBEK, E. SVATEK, M. PROTIVA,
... propyl chloride afforded the N-substituted derivatives of nordazepam III and IV ; compound IV revealed properties of ...
Tópico(s): Coordination Chemistry and Organometallics
1980 - Wiley-VCH | Collection of Czechoslovak Chemical Communications
... the rat, except for very high doses of nordazepam. The interaction results from a pharmacokinetic process. In ...
Tópico(s): Poisoning and overdose treatments
2009 - Elsevier BV | Annales Pharmaceutiques Françaises
Pilar Fernández Fernández, Isaac Lourido, Ana María Bermejo, Manuel López‐Rivadulla, Angelines Cruz, L. Concheiro,
... determination of diazepam and its three active metabolites, nordazepam, oxazepam and temazepam, in plasma was proposed. The ...
Tópico(s): Analytical Chemistry and Chromatography
1991 - Marcel Dekker | Journal of Liquid Chromatography
Herschel Sidransky, Ethel Verney, James W. Cosgrove, Arnold M. Schwartz,
... that the addition of chlordiazepoxide, diazepam, prazepam, flurazepam, nordazepam, N-desalkylflurazepam, temazepam, oxazepam, lorazepam, or 4-chlorodiazepam ...
Tópico(s): Endoplasmic Reticulum Stress and Disease
1992 - SAGE Publishing | Toxicologic Pathology
Thomas Stebler, Theodor W. Guentert,
Tópico(s): Veterinary Pharmacology and Anesthesia
1992 - Springer Science+Business Media | Pharmaceutical Research
Stéphane Pirnay, Ivan Ricordel, Danielle Libong, Stéphane Bouchonnet,
... among the most frequently encountered in forensic toxicology: nordazepam, oxazepam, bromazepam, flunitrazepam and prazepam.
Tópico(s): Analytical Chemistry and Chromatography
2002 - Elsevier BV | Journal of Chromatography A
Wayne M. Mullett, K. Levsen, Dieter Lubda, Janusz Pawliszyn,
... the sample preparation requirements. The calculated oxazepam, temazepam, nordazepam and diazepam detection limits were 26, 29, 22 ...
Tópico(s): Forensic Toxicology and Drug Analysis
2002 - Elsevier BV | Journal of Chromatography A
Anna Koski, Ilkka Ojanperä, Erkki Vuori,
... ethanol with any combination of diazepam, chlordiazepoxide, and nordazepam. Results The median concentration of ethanol was 3. ...
Tópico(s): Alcohol Consumption and Health Effects
2002 - Wiley | Alcoholism Clinical and Experimental Research
Beat Aebi, R Sturny-Jungo, Wolfgang Bernhard, Robert V. Blanke, Roman Hirsch,
... of a mixture of three selected benzodiazepines (diazepam, nordazepam and bromazepam) were used to compare gas chromatography ( ...
Tópico(s): Analytical Methods in Pharmaceuticals
2002 - Elsevier BV | Forensic Science International
Wayne M. Mullett, Janusz Pawliszyn,
... the extracted compounds. The calculated clonazepam, oxazepam, temazepam, nordazepam, and diazepam detection limits were 600, 750, 333, ...
Tópico(s): Analytical Chemistry and Chromatography
2002 - American Chemical Society | Analytical Chemistry