Masahito Ochiai, Norihiro Tada, Yoshio Nishi, Kentaro Murai,
Exposure of 1-alkynyl[p-(trifluoromethyl)phenyl](tetrafluoroborato)-λ3-bromanes to sodium benzenesulfinate or sodium trifluoromethanesulfinate in dichloromethane at 0 °C under argon resulted in tandem Michael–carbene insertion reactions to produce 1-sulfonylcyclopentenes selectively, with concomitant formation of a small amount of rearranged 1-alkynyl sulfones.
Tópico(s): Asymmetric Synthesis and Catalysis
2004 - Royal Society of Chemistry | Chemical Communications
Norihiro Tsujioka, Seiichi Imakura, Naoya Nishi, Takashi Kakiuchi,
Ion transfer across the polarized interface between a room-temperature ionic liquid (RTIL) or room-temperature molten salt, tetrahexylammonium bis(trifluoromethylsulfonyl)imide (THAC(1)C(1)N), and water has been studied voltammetrically using a micro liquid-liquid interface formed at the orifice of a glass capillary micropipette. A small current of nanoampere level circumvents the problem of the iR drop in the viscous ionic liquid phase. Voltammograms for the transfer of moderately hydrophilic ions, ...
Tópico(s): Analytical Chemistry and Sensors
2006 - Springer Nature | Analytical Sciences
Takashi Kakiuchi, Norihiro Tsujioka, Kenji Sueishi, Naoya Nishi, Masahiro Yamamoto,
The polarized potential window (ppw) of 450 mV is available at the interface between water (W) and the room-temperature molten salt (RTMS) that consists of tetraoctylammonium cations and trifluoromethylsulfonylnonafluoro-butylsulfonylimide anions. The ppw at the interface between W and RTMS made of several combinations of hydrophobic cations and anions is correlated with the standard ion-transfer potentials of the ions at the 1,2-dichloroethane | W interface. This correlation is useful not only to predict ...
Tópico(s): Analytical Chemistry and Sensors
2004 - The Electrochemical Society of Japan | Electrochemistry
Kazuno Arai, Hajime Naruse, Ryo Miura, Kiichiro Kawamura, Ryota Hino, Yoshihiro Ito, Daisuke Inazu, Miwa Yokokawa, Norihiro IZUMI, Masafumi Murayama, Takafumi Kasaya,
... this author on: GSW Google Scholar Norihiro Izumi; Norihiro Izumi 8Department of Civil Engineering, Hokkaido University, Nishi 8, Kita 13, Kita-ku, Sapporo, Hokkaido 060- ...
Tópico(s): Geological and Geochemical Analysis
2013 - Geological Society of America | Geology
Akimasa Hayashi, Naoko Yamauchi, Junji Shibahara, Hiroshi Kimurâ, Teppei Morikawa, Shumpei Ishikawa, Genta Nagae, Akihiro Nishi, Yoshihiro Sakamoto, Norihiro Kokudo, Hiroyuki Aburatani, Masashi Fukayama,
Analysis of acetylation and tri-methylation of the same residue of histone molecules might identify a subset of hepatocellular carcinoma (HCC) with aggressive behavior. In the present study, we examined acetylation and tri-methylation of lysine 27 on histone H3 (H3K27ac and H3K27me3, respectively) because these two modifications are known to exhibit opposite effects (enhancing and silencing) on gene expression. Neoplastic and non-neoplastic tissues from 198 HCC cases were immunostained with specific ...
Tópico(s): Genomics and Chromatin Dynamics
2014 - Public Library of Science | PLoS ONE
Sakine Nishi, Tsutomu Kobayashi, Norihiro Tanahashi, Masahide Yamaguchi,
We derive the cosmological matching conditions for the homogeneous and isotropic background and for linear perturbations in Horndeski's most general second-order scalar-tensor theory. In general relativity, the matching is done in such a way that the extrinsic curvature is continuous across the transition hypersurface. This procedure is generalized so as to incorporate the mixing of scalar and gravity kinetic terms in the field equations of Horndeski's theory. Our matching conditions have a wide ...
Tópico(s): Galaxies: Formation, Evolution, Phenomena
2014 - Institute of Physics | Journal of Cosmology and Astroparticle Physics
Masahito Ochiai, Yoshio Nishi, Takeshi Mori, Norihiro Tada, Takashi Suefuji, Hermann Josef Frohn,
Reported here for the first time are the synthesis, isolation, and characterization of hypervalent beta-haloalkenyl-lambda3-bromanes. Exposure of terminal alkynes to p-trifluoromethylphenyl(difluoro)-lambda3-bromane activated by BF3-i-Pr2O resulted in fluoro-lambda3-bromanation of the triple bonds in a Markovnikov fashion, yielding (E)-beta-fluoroalkenyl-lambda3-bromanes stereoselectively in good yields. 5-Chloro-1-pentynes undergo domino lambda3-bromanation-chlorine shift-fluorination or lambda3- ...
Tópico(s): Synthesis and Biological Evaluation
2005 - American Chemical Society | Journal of the American Chemical Society
... and temporal description logics Get access Norihiro Kamide Norihiro Kamide Waseda Institute for Advanced Study, Waseda University, 1-6-1 Nishi Waseda, Shinjuku-ku, Tokyo 169-8050, Japan.E- ...
Tópico(s): Logic, programming, and type systems
2011 - Oxford University Press | Journal of Logic and Computation
Keitaro Kanda, Jiro Sakamoto, Y Matsumoto, Kozo Ikuta, Norihiro Goto, Yusuke Morita, Mikiko Ohno, Kiyoto Nishi, Koji Eto, Yuto Kimura, Yuki Nakanishi, Kanako Ikegami, Takaaki Yoshikawa, Akihisa Fukuda, Kenji Kawada, Yoshiharu Sakai, Akihiro Ito, Minoru Yoshida, Takeshi Kimura, Tsutomu Chiba, Eiichiro Nishi, Hiroshi Seno,
Colon cancer is a complex disease affected by a combination of genetic and epigenetic factors. Here we demonstrate that nardilysin (N-arginine dibasic convertase; NRDC), a metalloendopeptidase of the M16 family, regulates intestinal tumorigenesis via its nuclear functions. NRDC is highly expressed in human colorectal cancers. Deletion of the Nrdc gene in ApcMin mice crucially suppressed intestinal tumor development. In ApcMin mice, epithelial cell-specific deletion of Nrdc recapitulated the tumor ...
Tópico(s): Signaling Pathways in Disease
2018 - American Society for Clinical Investigation | JCI Insight
Tomio Nishi, Norihiro Suzuki, Takayuki Tani, Hiroshi Aonuma,
A 45-year-old male presented to the emergency room of our institution complaining of severe pain around the left elbow. While playing volleyball, he slipped down with his left arm hit between the floor and his body. He complaind of strong pain from left elbow to hand, and active motion of elbow and wrist joint was impossible. His forearm was held in supinated position. On X-ray examination, radius head was deviated to anterior lateral side, and distal end of radius was dislocated to dorsal side. ...
Tópico(s): Shoulder Injury and Treatment
2013 - Hindawi Publishing Corporation | Case Reports in Orthopedics
Norihiro Kamide, Nishi Waseda,
Temporal description logics (TDLs) have been studied by many researchers (see e.g., [1, 10] for surveys and [4, 2, 15] for recent or important results). These TDLs are, however, not compatible in the following sense: these are not embeddable into the standard (non-temporal) description logics (DLs), and hence the existing algorithms for testing satisfiability in the standard DLs are not available for these TDLs. Such a compatibility issue is important for obtaining reusable and practical algorithms for ...
Tópico(s): Advanced Database Systems and Queries
2010 - Samara National Research University | CEUR Workshop Proceedings
Kiyoaki Sugiura, Yuki Seo, Takayuki Takahashi, Hideyuki Tokura, Yasuhiro Ito, Motomu Tanaka, Norihiro Kishida, Yusuke Nishi, Yoshihiko Onishi, Hikaru Aoki,
Abstract Background TAS-102 plus bevacizumab is an anticipated combination regimen for patients who have metastatic colorectal cancer. However, evidence supporting its use for this indication is limited. We compared the cost-effectiveness of TAS-102 plus bevacizumab combination therapy with TAS-102 monotherapy for patients with chemorefractory metastatic colorectal cancer. Method Markov decision modeling using treatment costs, disease-free survival, and overall survival was performed to examine ...
Tópico(s): Economic and Financial Impacts of Cancer
2021 - BioMed Central | BMC Gastroenterology
Masakazu Yoshioka, Takeshi Mori, Toshiyuki Okuma, Nobuo Kitamura, Norihiro Ito, Kazuhiko Nishi,
Tópico(s): Gestational Trophoblastic Disease Studies
2000 - Springer Nature | The Japanese Journal of Thoracic and Cardiovascular Surgery
Tomoko Tamaki, Kennosuke Karube, Shugo Sakihama, Yuma Tsuruta, Ryoko AWAZAWA, Masaki Hayashi, Norihiro Nakada, Hirofumi Matsumoto, Nobutake YAGI, Kazuiku Ohshiro, Iwao Nakazato, Sakiko Kitamura, Yukiko Nishi, Takuya Miyagi, Sayaka Yamaguchi, Sawako Nakachi, Satoko Morishima, Hiroaki Masuzaki, Kenzo Takahashi, Takuya Fukushima, Naoki Wada,
Adult T-cell leukemia/lymphoma (ATLL) is a mature T-cell tumor caused by human T-lymphotropic virus type 1 (HTLV-1). The typical ATLL immunophenotypes are described in the 2017 World Health Organization Classification of Tumours of Haematopoietic and Lymphoid Tissues (positive: CD2, CD3, CD5, CD4, and CD25; negative: CD7, CD8, and cytotoxic markers; and partially positive: CD30, CCR4, and FOXP3). However, limited studies are available on the expression of these markers, and their mutual relationship ...
Tópico(s): Animal Disease Management and Epidemiology
2023 - Elsevier BV | Modern Pathology
Heinrich Wansing, Norihiro Kamide,
... author on: Oxford Academic Google Scholar Norihiro Kamide Norihiro Kamide Waseda Institute for Advanced Study, Waseda University,1-6-1 Nishi Waseda, Shinjuku-ku, Tokyo 169-8050, JapanE-mail: ...
Tópico(s): Rough Sets and Fuzzy Logic
2010 - Oxford University Press | Journal of Logic and Computation
Kiyoaki Sugiura, Yuki Seo, Hikaru Aoki, Yoshihiko Onishi, Yusuke Nishi, Norihiro Kishida, Motomu Tanaka, Yasuhiro Ito, Hideyuki Tokura, Takayuki Takahashi,
Tópico(s): Hernia repair and management
2022 - Springer Science+Business Media | Surgery Today
... for linear-time formalism Get access Norihiro Kamide Norihiro Kamide Waseda Institute for Advanced Study, Waseda University, 1-6-1 Nishi Waseda, Shinjuku-ku, Tokyo 169-8050, JAPAN. Search ...
Tópico(s): Logic, Reasoning, and Knowledge
2010 - Oxford University Press | Logic Journal of IGPL
Arata Oh‐Nishi, Makoto Saji, Shigeki Satoh, Masao Ogata, Norihiro Suzuki,
Abstract Activation of N -methyl-d-aspartic acid (NMDA) glutamate receptors (NMDARs) is required for long-term potentiation (LTP) of excitatory synaptic transmission at hippocampal CA1 synapses, the proposed cellular mechanisms of learning and memory. We demonstrate here that a brief bath co-application of a low concentration of NMDA, an agonist of NMDARs, and the selective antagonist of NR2B-containing NMDARs, (α R, β S)-α-(4-hydroxyphenyl)-β-methyl-4-(phenylmethyl)-1-piperidinepropanol (Ro25-6981), to hippocampal ...
Tópico(s): Neuroinflammation and Neurodegeneration Mechanisms
2008 - Elsevier BV | Neuroscience
Shimon Kurasawa, Yoshinari Yasuda, Sawako Kato, Shoichi Maruyama, Hirokazu Okada, Naoki Kashihara, Ichiei Narita, Takashi Wada, Kunihiro Yamagata, Tomoya Hirayama, Nobuhiko Togashi, Akira Sugiura, Kunihiro Yamagata, Tatsuo Shiigai, Kazue Ueki, Ken Kikkawa, Tsukasa Nakamura, Eiichi Sato, Hideki Matsukuma, Shinsuke Harasawa, Takehiko Washio, Yuko Shibuya, Hitoshi Tagawa, Takashi Yasuda, Shuzo Kobayashi, Masaki Nagasawa, Minako Wakasugi, Hajime Yamazaki, Michio Matsumoto, Shoichi Maruyama, Norihiro Suga, Keiichi Tamagaki, Taiko Kimura, Tsutomu Tabata, Yoshihiro Tsujimoto, Shinichi Nishi, Y Yonekura, Hitoshi Sugiyama, Naoki Kashihara, Tadashi Sofue, Kazuhiko Tsuruya, Toshiaki Nakano, Masato Tadokoro, Shoichi Fujimoto, Masao Kikuchi, Kiyoyuki Tokuyama,
Tópico(s): Renal and Vascular Pathologies
2023 - Springer Nature | Hypertension Research
Yasuyo Nishi, Hajime Shinoda, Atsuro Uchida, Takashi Koto, Hiroshi Mochimaru, Norihiro Nagai, Kazuo Tsubota, Yoko Ozawa,
Abstract. Purpose: Patients with epiretinal membrane sometimes complain of impaired central visual function, despite good best corrected visual acuity (BCVA), as measured by visual acuity (VA) charts. Here, we evaluate early epiretinal membrane–induced changes in central VA. Methods: Subjects were 72 eyes of 36 patients with epiretinal membrane in only one eye and a BCVA in each eye better than 1.0, as measured by conventional Landolt C chart, at the Retina Division Clinic of the Department of Ophthalmology, ...
Tópico(s): Glaucoma and retinal disorders
2013 - Wiley | Acta Ophthalmologica
Norihiro Okada, Kenshiro Oshima, Yuki Iwasaki, Akiko Maruko, Kenya Matsumura, Erica Iioka, Trieu-Duc Vu, Naoki Fujitsuka, Akinori Nishi, Aiko Sugiyama, Mitsue Nishiyama, Atsushi Kaneko, Kazushige Mizoguchi, Masahiro Yamamoto, Susumu Nishimura,
Intron retention (IR) is an important regulatory mechanism that affects gene expression and protein functions. Using klotho mice at the pre-symptomatic state, we discovered that retained-introns accumulated in several organs including the liver and that among these retained introns in the liver a subset was recovered to the normal state by a Japanese traditional herbal medicine. This is the first report of IR recovery by a medicine. IR-recovered genes fell into two categories: those involved in liver- ...
Tópico(s): Cancer, Hypoxia, and Metabolism
2021 - Elsevier BV | Gene
Kiyoaki Sugiura, Yuki Seo, Hikaru Aoki, Yoshihiko Onishi, Yusuke Nishi, Norihiro Kishida, Motomu Tanaka, Yasuhiro Ito, Hideyuki Tokura, Takayuki Takahashi,
Few studies have compared management and outcomes of bridge to surgery (BTS) for obstructive colonic cancer according to the location of the tumor. Additional information is needed about this procedure's characteristics and short-term and long-term outcomes. We aimed to compare patient and tumor characteristics, and outcomes of BTS for obstructive right-sided versus left-sided colonic cancers.This was a retrospective, single center, cohort study. The study cohort comprised 149 patients, including ...
Tópico(s): Gastric Cancer Management and Outcomes
2021 - | Journal of the Anus Rectum and Colon
Atsushi Takahara, Yoshio Nishi, Norihiro Kaiya, Tisato Kajiyama,
The high-density polyethylene (HDPE) films have been prepared either through melt quenching or isothermal crystallization. The fatigue behavior of those HDPE films under constant strain amplitude has been investigated based on dynamic viscoelastic and small angle light scattering (SALS) measurements during the fatigue process. Non-linear viscoelastic behavior under cyclic fatigue has been observed for both melt quenched and isothermally crystallized HDPE's. Melt quenched HDPE showed greater fatigue ...
Tópico(s): Mechanical Behavior of Composites
1991 - Society of Rheology, Japan | Nihon Reoroji Gakkaishi
Masayuki Ide, Tetsuo Ohnishi, Manabu Toyoshima, Shabeesh Balan, Motoko Maekawa, Chie Shimamoto‐Mitsuyama, Yoshimi Iwayama, Hisako Ohba, Akiko Watanabe, Takashi Ishii, Norihiro Shibuya, Yuka Kimura, Yasuko Hisano, Y. Murata, Tomonori Hara, Momo Morikawa, Kenji Hashimoto, Yayoi Nozaki, Tomoko Toyota, Yuina Wada, Yosuke Tanaka, Tadafumi Kato, Akinori Nishi, Shigeyoshi Fujisawa, Hideyuki Okano, Masanari Itokawa, Nobutaka Hirokawa, Yasuto Kunii, Akiyoshi Kakita, Hirooki Yabe, Kazuya Iwamoto, Kohji Meno, Takuya Katagiri, Brian Dean, Kazuhiko Uchida, Hideo Kimura, Takeo Yoshikawa,
Article28 October 2019Open Access Source DataTransparent process Excess hydrogen sulfide and polysulfides production underlies a schizophrenia pathophysiology Masayuki Ide Laboratory of Molecular Psychiatry, RIKEN Center for Brain Science, Wako, Saitama, Japan Department of Psychiatry, Division of Clinical Medicine, Faculty of Medicine, University of Tsukuba, Tsukuba, Ibaraki, Japan Search for more papers by this author Tetsuo Ohnishi Laboratory of Molecular Psychiatry, RIKEN Center for Brain Science, ...
Tópico(s): Cannabis and Cannabinoid Research
2019 - Springer Nature | EMBO Molecular Medicine
Hiroaki Tanaka, Hideaki Rikimaru, Yukiko Rikimaru‐Nishi, Norihiro Muraoka, Mina Anegawa, Shoya Ueki, Ou Oishi, Kensuke Kiyokawa,
Objective Stimulation of the subthalamic nucleus by implanted electrodes (deep brain stimulation [DBS]) is performed to suppress symptoms of Parkinson's disease. However, postoperative wound dehiscence and infection can require removal of the implanted electrode leads. This report describes treatment of intractable unilateral wound infection in two patients without removing the DBS device. Methods First, components of the DBS system were removed except for the electrode lead and thorough debridement ...
Tópico(s): Parkinson's Disease and Spinal Disorders
2020 - Thieme Medical Publishers (Germany) | Journal of Neurological Surgery Reports
Yasuo Morimoto, Akira Ogami, Motoi Todoroki, Makoto Yamamoto, Masahiro Murakami, Masami Hirohashi, Takako Oyabu, Toshihiko Myojo, Kenichiro Nishi, Chikara Kadoya, Sayumi Yamasaki, Hiroko Nagatomo, Katsuhide Fujita, Shigehisa Endoh, Kunio Uchida, Kazuhiro Yamamoto, Norihiro Kobayashi, Junko Nakanishi, Isamu Tanaka,
The objective of this study was to examine what kinds of cytokines are related to lung disorder by well-dispersed nanoparticles. The mass median diameter of nickel oxide in distilled water was 26 nm. Rats intratracheally received 0.2 mg of nickel oxide suspended in distilled water, and were sacrificed from three days to six months. The concentrations of 21 cytokines including inflammation, fibrosis and allergy-related ones were measured in the lung. Infiltration of alveolar macrophages was observed ...
Tópico(s): Occupational exposure and asthma
2010 - Taylor & Francis | Nanotoxicology
Kozo Ikuta, Akihisa Fukuda, Satoshi Ogawa, Kenji Masuo, Norihiro Goto, Yukiko Hiramatsu, Motoyuki Tsuda, Yoshito Kimura, Y Matsumoto, Yuto Kimura, Takahisa Maruno, Keitaro Kanda, Kiyoto Nishi, Kyoichi Takaori, Shinji Üemoto, Shigeo Takaishi, Tsutomu Chiba, Eiichiro Nishi, Hiroshi Seno,
Objective Nardilysin (NRDC), a zinc peptidase, exhibits multiple localisation-dependent functions including as an enhancer of ectodomain shedding in the extracellular space and a transcriptional coregulator in the nucleus. In this study, we investigated its functional role in exocrine pancreatic development, homeostasis and the formation of pancreatic ductal adenocarcinoma (PDA). Design We analysed Ptf1a-Cre; Nrdc flox/flox mice to investigate the impact of Nrdc deletion. Pancreatic acinar cells were ...
Tópico(s): Diabetes Treatment and Management
2018 - BMJ | Gut
Sho Ishihara, Akio Yanagisawa, Hirotoshi Ohta, Masashi Ueno, Masami Arai, Makoto Seki, Norihiro Kokudo, Keiichiro Ohta, Takashi Takahashi, Mitsumasa Nishi,
Liver metastasis has the highest incidence of course of death in patients with early gastric carcinoma. We analyzed 14 patients with early gastric carcinoma and liver metastasis clincopathologically to ascertain the clinicopathologic features of the high risk group for liver metastasis in early gastric carcinoma. A series of 304 patients with early gastric carcinoma without liver metastasis were served as controls. The clinicopathologic features of early gastric carcinomas with liver metastasis ...
Tópico(s): Gastrointestinal Tumor Research and Treatment
1999 - Japan Surgical Association | Nihon Rinsho Geka Gakkai Zasshi (Journal of Japan Surgical Association)
Masatake Nishi, Yoshiyuki Abe, Sakashi Fujimori, Atsushi Hamamoto, Yoshimasa Inoue, Noriyuki MIYAZAKI, Yasuhisa Oida, Norihiro Ikoma, Yasuyuki Ohnishi, Hitoshi Yamazaki, Yoshito Ueyama, Masato Nakamura,
Glutamate cysteine ligase (GCL) plays an important role in the intracellular detoxification of cisplatin (CDDP). GCL is composed of a modifier or light chain subunit (GCLM) and a catalytic or heavy chain subunit (GCLC). Previously, we showed that the GCL subunits enhanced CDDP-resistance in non-small cell lung cancer (NSCLC) xenografts. In small cell lung cancer (SCLC), it is unclear whether the GCL subunits are essential to CDDP-resistance. We examined the gene expression of GCLM and GCLC in four human ...
Tópico(s): Neuroendocrine Tumor Research Advances
2005 - Elsevier BV | Oncology Reports
Tetsu Ohnuma, Yoshiro Hayashi, Kazuto Yamashita, John Marquess, Alan Kawarai Lefor, Masamitsu Sanui, Kenji Andoh, Moritoki Egi, Motoki Fujita, Shigeki Fujitani, Yasuhiro Gushima, Kenji Hagiya, Hideharu Hagiya, Takeshi Ide, Yusuke Iizuka, Tetsu Ohnuma, Taiga Itagaki, Tetsuya Ito, Michiho Ito, Yoshiaki Iwashita, Junichi Izawa, S. Izuta, K Kabutan, Masayuki Kamochi, Masahiro Kashiura, Koichi Matsuo, Hideaki Matsushima, Dai Miyazaki, M Miyazu, I. Nagata, Tatsuro Takei, Hiroshi NAGATANI, M Nakagawa, Motoyuki Nakane, Kosuke Nishi, M. Noguchi, Tomohisa Nomura, Shin Nunomiya, Takehisa Obayashi, T. Oda, Kenichi Oe, Kazuki Ota, Norihiro Saito, Shigeki Sako, Motohiro Sekino, Ryutaro Seo, Yutaka Shiino, Nobuaki Shime, Koki Shimizu, Katsumi Takada, Kazuto Takimoto, Mitsuaki Taneda, K. Uehara, Kyoko Unemoto, Toshiyuki Yamada, Hideto Yasuda,
Although most patients in the intensive care unit (ICU) receive antibiotics, little is known about patterns of antibiotic use in ICUs in Japan. The objective of this study was to evaluate the pattern of antibiotic use in ICUs. A nationwide one-day cross-sectional surveillance of antibiotic use in the ICU was conducted three times between January 2011 and December 2011. All patients aged at least16 years were included. Data from 52 ICUs and 1148 patients were reviewed. There were 1028 prescriptions ...
Tópico(s): Nosocomial Infections in ICU
2018 - Elsevier BV | International Journal of Antimicrobial Agents