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Artigo Acesso aberto Revisado por pares

Timothy I. Richardson, Christian A. Clarke, Kuo‐Long Yu, Ying K. Yee, Thomas J. Bleisch, José Enrique López, Scott A. Jones, Norman E. Hughes, Brian S. Muehl, Charles W. Lugar, Terry L. Moore, Pamela K. Shetler, Richard W. Zink, John Osborne, Chahrzad Montrose‐Rafizadeh, Nita Patel, Andrew G. Geiser, Rachelle J. Sells Galvin, Jeffrey A. Dodge,

We report the synthesis and characterization of novel 3-aryl indoles as potent and efficacious progesterone receptor (PR) antagonists with potential for the treatment of uterine fibroids. These compounds demonstrated excellent selectivity over other steroid nuclear hormone receptors such as the mineralocorticoid receptor (MR). They were prepared from 2-bromo-6-nitro indole in four to six steps using a Suzuki cross-coupling as the key step. Compound 8f was orally active in the complement 3 model of ...

Tópico(s): Estrogen and related hormone effects

2010 - American Chemical Society | ACS Medicinal Chemistry Letters

Artigo Revisado por pares

Rhonda F. Souza, Joel H. Rubenstein, John Y. Kao, Ikuo Hirano,

... That same year, Gerson et al19Gerson L.B. Shetler K. Triadafilopoulos G. Prevalence of Barrett's esophagus ...

Tópico(s): Eosinophilic Disorders and Syndromes

2018 - Elsevier BV | Gastroenterology