Darren Hodgson, Sylvaine Gasparini, Pascal Drevet, Frédéric Ducancel, Françoise Bouet, Jean‐Claude Boulain, John B. Harris, Andre Ménèz,
... a methionine residue and the phospholipase A 2 notechis 11′2L, an isoform of notexin of Notechis scutatus scutatus , venom. Notechis 11′2L is a mutant of the naturally occuring notechis 11′2 [Bouchier, C., Boyot, P., Tesson, F., ... amino acid composition and N‐terminal sequence of notechis 11′2L. Notechis 11′2L and the wild notechis 11′2 displayed identical circular dichroic spectra and ... myotoxic and antigenic properties, suggesting that the recombinant notechis 11′2L was directly generated in a correctly ...
Tópico(s): Nicotinic Acetylcholine Receptors Study
1993 - Wiley | European Journal of Biochemistry
C.C. Yang, Long‐Sen Chang, Fang‐Jy Wu,
Column chromatography and polyacrylamide gel electrophoresis of Notechis scutatus scutatus venom showed that the venoms from different geographical locations had variations in their constituents. The venom collected from South Australia region contained both notexin and notechis II-5. The relative quantity of notechis II-5 was about three times that of ... region contained large amounts of notexin, but lacked notechis II-5. Instead, an unknown nontoxic protein, designated as notechis II-5b, exhibiting weak phospholipase A2 activity appeared ...
Tópico(s): Insect and Pesticide Research
1991 - Elsevier BV | Toxicon
Brian R. Francis, Ted R. John, Corrine Seebart, Ivan I. Kaiser,
... from the venom of the Australian tiger snake, Notechis scutatus scutatus. Both isoforms, of apparent mol. wt ... 000, are less basic than either notexin or notechis II-5. They both have similar i.v. ... notexin and about seven times more potent than notechis II-5. ELISAs and western blot analyses indicate ... new toxins are immunologically similar to notexin and notechis II-5, with phospholipase activities falling between these ... the previously reported non-toxic and enzymatically inactive notechis II-1. The combination of gel filtration on ...
Tópico(s): Nicotinic Acetylcholine Receptors Study
1991 - Elsevier BV | Toxicon
J.B. Harris, Margaret A. Johnson,
... from the venom of the Australian tiger snake, Notechis scutatus scutatus, are described. 2. The toxins used were notexin, notechis II-5, notechis II-1 and a modified form of notexin ( ... that caused by notexin. It was identified as notechis II-5. A third fraction, notechis II-1, was found to be inactive. 6. ...
Tópico(s): Rabies epidemiology and control
1978 - Wiley | Clinical and Experimental Pharmacology and Physiology
Michael Wisniewski, Robert E. Hill, Joshua M. Havey, Gregory M. Bogdan, Richard C. Dart,
... Mexican Micrurus (coral snake) antivenom and an Australian Notechis (tiger snake) antivenom to prevent lethality from a ... venom+Micrurus antivenom, (2) M. f. fulvius venom+Notechis antivenom, (3) M. f. fulvius venom+protein control, ( ... 0.9% normal saline+protein control, (5) saline+Notechis antivenom, (6) saline+Micrurus antivenom. Venom dose was ... observation period. Conclusions: Mexican Micrurus antivenom and Australian Notechis antivenom provide protection from lethality in mice envenomated ...
Tópico(s): Insect and Pesticide Research
2003 - Marcel Dekker | Journal of Toxicology Clinical Toxicology
Peter G. Hains, Kah-Leong Sung, Albert Tseng, Kevin W. Broady,
... inhibitor has been purified from the serum of Notechis ater using DEAE-Sephacel chromatography. The inhibitor was ... inhibitor has been purified from the serum of Notechis ater using DEAE-Sephacel chromatography. The inhibitor was ... purification and functional characterization of a PLI from Notechis ater (Australian tiger snake) serum. The inhibitor termed, ... micromole range dependent on the PLA2examined. Notexin from Notechis scutatus (Common tiger snake) and taipoxin from Oxyuranus ...
Tópico(s): Vitamin K Research Studies
2000 - Elsevier BV | Journal of Biological Chemistry
Venoms from Notechis scutatus scutatus, Notechis ater serventyi, Notechis ater humphreysi and Notechis ater ater were compared using gel filtration, polyacrylamide gel electrophoresis, and western blotting. All ...
Tópico(s): Ion channel regulation and function
1990 - Elsevier BV | Toxicon
The complete amino acid sequence of notechis 5, a neurotoxic phospholipase A from the venom of Notechis scutatus scutatus (Australian tiger snake), has been elucidated. The main fragmentation of ... degradation by means of the direct phenylthiohydantoin method. Notechis 5 differs in seven positions from the recently ... the presynaptic neurotoxin notexin from the same venom. Notechis 5 has a 50% higher specific prospholipase A ...
Tópico(s): Ion channel regulation and function
1976 - Elsevier BV | Journal of Biological Chemistry
Christiane Bouchier, P. Boyot, Frédérique Tesson, O. Trémeau, Françoise Bouet, Darren Hodgson, Jean‐Claude Boulain, Andre Ménèz,
... from the venom gland of the Australian elapid Notechis scutatus scutatus . The corresponding protein has now been identified, purified from the venom and named Notechis 11′2. Its complete amino acid sequence has ... the residues putatively required for PLA 2 activity, Notechis 11′2 exhibits an esterase activity, preferentially against ... toxic PLA 2 present in the venom of Notechis scutatus scutatus , notechis 11′2 has no lethal activity. This observation ... that the lethal activity of PLA 2 from Notechis scutatus scutatus is not due to the esterasic ...
Tópico(s): Marine Invertebrate Physiology and Ecology
1991 - Wiley | European Journal of Biochemistry
Geoffrey K. Isbister, Nicholas A. Buckley, Simon G.A. Brown,
... Issue 4 p. 194-195 Letter Tiger snake (Notechis spp) envenoming: Australian Snakebite Project (ASP-13) Geoffrey ... Leary MA, Elliott M, Brown SG. Tiger snake (Notechis spp) envenoming: Australian Snakebite Project (ASP-13). Med ... com.au/journal/2012/197/3/tiger-snake-notechis-spp-envenoming-australian-snakebite-project-asp-13 4Whyte ...
Tópico(s): Bioactive Natural Diterpenoids Research
2013 - Wiley | The Medical Journal of Australia
... studied in four island populations of tiger snakes (Notechis ater) in southern Australia. Within islands, snakes were ... bians and Reptiles l atterns in Tiger Snakes (Notechis ater. Elapidae) on Dispersion is the spatial pattern ... During mark-recapture studies of black tiger snakes (Notechis ater) on several offshore islands in southern Australia ( ...
Tópico(s): Animal Ecology and Behavior Studies
1991 - The Society for the Study of Amphibians and Reptiles | Journal of Herpetology
Serge Chwetzoff, Pascale Mollier, Françoise Bouet, Edward G. Rowan, Alan L. Harvey, Andre Ménèz,
Venom of the Australian tiger snake, Notechis scutatus scutatus was fractionated by conventional ion-exchange chromatography. The fraction containing notexin, a well-known single-chain toxic phospholipase A2, was ... corresponded to notexin. The other component, designated as notechis Ns, was an isoform of notexin. Notechis Ns and notexin possessed similar in vitro esterase ... V8-protease peptides demonstrated that primary structures of notechis Ns and notexin differed from each other by ...
Tópico(s): Healthcare and Venom Research
1990 - Wiley | FEBS Letters
The complete amino acid sequence of Notechis II-1, a non-neurotoxic, non-enzymatic phospholipase A2 homolog from the venom of the Australian tiger snake Notechis s. scutatus has been determined. The protein consists ... which was determined mainly by automated Edman degradation. Notechis II-1 contains all of the residues that ...
Tópico(s): Biochemical and Structural Characterization
1980 - Wiley | European Journal of Biochemistry
James R. Halpert, Jan Fohlman, David Eaker,
... 60 percent of the protein in tiger snake (Notechis scutatus scutatus) venom consists of the basic per-synaptically neurotoxic and myotoxic phospholipases notexin and Notechis II-5 and other phospholipase homologs such as Notechis II-1, several post-synaptic "curaremimetic" neurotoxins are ...
Tópico(s): Insect and Pesticide Research
1979 - Elsevier BV | Biochimie
Hong-Liang Zhang, Yuming Li, Jing Sun, Yu-Yuan Zhang, Tong-Yun Wang, Ming-xia Sun, Meng-Hang Wang, Yue-Lin Yang, Xiao-Liang Hu, Yan-Dong Tang, Jincun Zhao, Xuehui Cai,
... ferrumequinum (greater horseshoe bat), Gallus gallus (red junglefowl), Notechis scutatus (mainland tiger snake), or Mus musculus (house ... ferrumequinum (greater horseshoe bat), Gallus gallus (red junglefowl), Notechis scutatus (mainland tiger snake), or Mus musculus (house ... Manis javanica (Malayan pangolin), Gallus gallus (red junglefowl), Notechis scutatus (mainland tiger snake), Mus musculus (house mouse), ...
Tópico(s): SARS-CoV-2 detection and testing
2021 - Elsevier BV | Journal of Biological Chemistry
Choo Hock Tan, Nget Hong Tan, Nget Hong Tan,
... this study, the venom of Australian tiger snake (Notechis scutatus) was trypsin-digested in solution and subjected ... the venom of common tiger snake from Australia, Notechis scutatus. The proteomic findings provided additional information on ...
Tópico(s): Rabies epidemiology and control
2016 - Elsevier BV | Journal of Proteomics
Geoffrey K. Isbister, Margaret A. O’Leary, Matthew Elliott, Simon G.A. Brown,
... Issue 3 p. 173-177 Research Tiger snake (Notechis spp) envenoming: Australian Snakebite Project (ASP-13) Geoffrey ... the clinical syndrome associated with definite tiger snake (Notechis spp) envenoming and to examine the ability of ...
Tópico(s): Food Allergy and Anaphylaxis Research
2012 - Wiley | The Medical Journal of Australia
... male combat occurs in mainland populations of tigersnakes (Notechis scutatus), but authorities have disagreed as to whether ... not this behaviour also occurs in island tigersnakes (Notechis ater). In this paper, we confirm that intraspecific ...
Tópico(s): Animal Behavior and Reproduction
1996 - Brill | Amphibia-Reptilia
... Australian elapid snakes. Two species of the genus Notechis were involved: Notechis ater (Black Tiger Snake) and Notechis scutatus (Eastern or Mainland Tiger Snake). The infection ...
Tópico(s): Dermatological diseases and infestations
1993 - Wiley | Australian Veterinary Journal
Sally Preston, Christine E. Davis, John B. Harris,
... International Reference Venom from the Australian tiger snake, Notechis scutatus, to study possible methods for the assessment ... the W.H.O. International Standard Antivenom for Notechis scutatus. Muscle wet weight increased following the inoculation ...
Tópico(s): Ion channel regulation and function
1990 - Elsevier BV | Toxicon
Pascale Mollier, Serge Chwetzoff, Paule Frachon, André Ménez,
... notexin, the most toxic phospholipase A2 (PLA2) from Notechis scutatus scutatus venom, without the necessity of detoxifying ... related isoforms of notexin and (iii) venoms from Notechis genus snakes. In contrast, they failed to recognize ...
Tópico(s): Nicotinic Acetylcholine Receptors Study
1989 - Wiley | FEBS Letters
Vaughan Williams, Jennifer A. White,
The procoagulant from Notechis ater niger was purified by gel filtration and anion exchange chromatography. It is a protein with an approximate mol. ... the venom. The activity of the procoagulant from Notechis species has been equated with factor Xa and ...
Tópico(s): Vitamin K Research Studies
1989 - Elsevier BV | Toxicon
Vaughan Williams, Jennifer A. White,
... a single isolated population of peninsula tiger snake (Notechis ater niger). Toxicon25, 1240 – 1243, 1987. — Venom from seven individuals in a homogeneous isolated population of Notechis ater niger on Roxby Island, off the South ...
Tópico(s): Healthcare and Venom Research
1987 - Elsevier BV | Toxicon
Lorraine Marshall, Richard Herrmann,
... man who was bitten by a bardick snake (Notechis curtus) and who, apart from marked local swelling, ... detection kit, but did not react with the Notechis antivenom. This anomalous reactivity was confirmed when dried ... are the venoms of other snakes of the Notechis genus. The clinical importance of these findings is ...
Tópico(s): Marine Invertebrate Physiology and Ecology
1984 - Wiley | The Medical Journal of Australia
Indira Sen, A. Baba, R. A. Schulz, J. R. Cooper,
Abstract The neurochemical activity of notexin and notechis II‐5 was investigated using a synaptosomal preparation of rat cerebral cortices. In preparations preincubated with [ 3 H]choline in order to label ... a concentration of 0.1 μM, notexin and notechis II‐5 caused a 50% increase in the ...
Tópico(s): Photoreceptor and optogenetics research
1978 - Wiley | Journal of Neurochemistry
Vijay Kumar, Thomas A. Rejent, W.B. Elliott,
... venoms from Naja, Bungarus, Ophiophagus, Dendroaspis, Hemachatus and Notechis species, only Notechis scutatus venom totally lacked anticholinesterase activity while N. ... magnesium, nickelous, stannous and manganous ions were inactive. Notechis scutatus and to a lesser extent Dendroaspis jamesoni ...
Tópico(s): Computational Drug Discovery Methods
1973 - Elsevier BV | Toxicon
... neurotoxins from the venom of the tiger snake Notechis scutatus scutatus Hazel M. Doery Hazel M. Doery ... neurotoxins from the venom of the tiger snake Notechis scutatus scutatus. Biochem J 1 December 1958; 70 ( ...
Tópico(s): Healthcare and Venom Research
1958 - Portland Press | Biochemical Journal
Damian C. Lettoof, Vy Nguyen, William R. Richmond, Helen E. Nice, Marthe Monique Gagnon, David J. Beale,
... a top predator of wetlands, the tiger snake (Notechis scutatus). Tiger snakes (18 male and 17 female) ...
Tópico(s): Effects and risks of endocrine disrupting chemicals
2023 - Elsevier BV | The Science of The Total Environment
Christina N. Zdenek, Bianca op den Brouw, Daniel Dashevsky, Alexandra Gloria, Nicholas J. Youngman, Ebony Watson, Patrick Green, Chris Hay, Nathan Dunstan, Luke Allen, Bryan G. Fry,
... currently known from the tiger snake clade (Hoplocephalus, Notechis, Paroplocephalus, and Tropidechis species), brown/taipan (Oxyuranus and ... relatedness of the species used in antivenom production (Notechis scutatus), which underscores a fundamental principle that the ...
Tópico(s): Marine Invertebrate Physiology and Ecology
2019 - Elsevier BV | Toxicology Letters
Alessandro Palci, Michael S. Y. Lee, Mark N. Hutchinson,
... bicolor , Cylindrophis ruffus , Aspidites melanocephalus , Acrochordus arafurae , and Notechis scutatus ] and two lizard outgroups ( Ctenophorus decresii , Varanus ... quadrates of the macrostomatan snakes Aspidites , Acrochordus and Notechis , but also, surprisingly, in the iguanian lizard Ctenophorus . ...
Tópico(s): Evolution and Paleontology Studies
2016 - Wiley | Journal of Anatomy