Toshifumi Tada, Takashi Kumada, Hidenori Toyoda, Takanori Ito, Yasuhiro Sone, Seiji Okuda, Nozomi Tsuji, Yumi Imayoshi, Eisuke Yasuda,
To clarify the diagnostic impact of liver fibrosis except for cirrhosis identified using shear wave elastography (SWE) in chronic hepatitis C (CHC) patients, and to compare the performance in diagnosing liver fibrosis among SWE and liver fibrosis indices.A total of 55 CHC patients who underwent liver biopsy were analyzed. The diagnostic performance for identifying significant liver fibrosis (F2-F3) for SWE, FIB-4 index, aspartate aminotransferase-to-platelet ratio index (APRI) and Forns' index was assessed ...
Tópico(s): Hepatitis B Virus Studies
2015 - Wiley | Hepatology Research
Yoshihiko Hirotani, Nozomi Ozaki, Yoshihiro Tsuji, Yoko Urashima, Michiaki Myotoku,
We investigated the ability of eicosapentaenoic acid (EPA) to prevent high-fat diet (HFD)-induced obesity and non-alcoholic fatty liver disease (NAFLD). Male C57BL/6J mice were fed standard chow (5.3% fat content), an HFD (32.0% fat content) or an HFD + EPA (1 g/kg/day EPA for the last 6 weeks) for 12 weeks. Serum total cholesterol, hepatic triglyceride and total cholesterol levels were significantly increased in the HFD group, in comparison with those of normal mice (p < 0.01). In contrast, hepatic triglyceride ...
Tópico(s): Diet, Metabolism, and Disease
2015 - Taylor & Francis | International Journal of Food Sciences and Nutrition
Yuka Ikeda, Nozomi Nagase, Ai Tsuji, Yasuko Kitagishi, Satoru Matsuda,
Alzheimer's disease (AD) is the most common reason for progressive dementia in the elderly. It has been shown that disorders of the mammalian/mechanistic target of rapamycin (mTOR) signaling pathways are related to the AD. On the other hand, diabetes mellitus (DM) is a risk factor for the cognitive dysfunction. The pathogenesis of the neuronal impairment caused by diabetic hyperglycemia is intricate, which contains neuro-inflammation and/or neurodegeneration and dementia. Glucagon-like peptide-1 (GLP1) ...
Tópico(s): Metabolism, Diabetes, and Cancer
2021 - Baishideng Publishing Group | World Journal of Biological Chemistry
Yuka Ikeda, Kurumi Taniguchi, Nozomi Nagase, Ai Tsuji, Yasuko Kitagishi, Satoru Matsuda,
Excessive reactive oxygen species (ROS) may cause oxidative stress which is involved in aging and in the pathogenesis of various human diseases. Whereas unregulated levels of the ROS may be harmful, regulated basal level of ROS are even necessary to support cellular functions as a second messenger for homeostasis under physiological conditions. Therefore, redox medicine could develop as a new therapeutic concept for human health-benefits. Here, we introduce the involvement of ROS on the crossroads ...
Tópico(s): Cancer, Hypoxia, and Metabolism
2021 - | Exploration of Medicine
Tomoyuki Nakamura, Yuko Sato, Daisuke Watanabe, Hideki Ito, Nozomi Shimonohara, Takahiro Tsuji, Noriko Nakajima, Yoshio Suzuki, Koma Matsuo, Hidemi Nakagawa, Tetsutaro Sata, Harutaka Katano,
To clarify whether mutations in the large T gene encoded by Merkel cell polyomavirus affect the expression and function of large T antigen in Merkel cell carcinoma cases, we investigated the expression of large T antigen in vitro and in vivo. Immunohistochemistry using a rabbit polyclonal antibody revealed that large T antigen was expressed in the nuclei of Merkel cell carcinoma cells with Merkel cell polyomavirus infection. Deletion mutant analyses identified an Arg–Lys–Arg–Lys sequence (amino acids ...
Tópico(s): Antenna Design and Analysis
2010 - Elsevier BV | Virology
Masaharu Tsuji, Nozomi Nakamura, Masatoshi Ogino, Koji Ikedo, Mika Matsunaga,
Octahedral and decahedral Au@Ag core-shell nanocrystals have been prepared in high yields using a two-step reduction method. In the first step, octahedral or decahedral Au core seeds were prepared by reducing HAuCl4·4H2O in tetraethylene glycol (TEG) under microwave (MW) heating or in diethylene glycol (DEG) under oil-bath heating, respectively, in the presence of polyvinylpyrrolidone (PVP) as a polymer surfactant. In the second step, Ag shells were overgrown on these Au seeds in N,N-dimethylformamide ( ...
Tópico(s): Quantum Dots Synthesis And Properties
2012 - Royal Society of Chemistry | CrystEngComm
Yuka Ikeda, Nozomi Nagase, Ai Tsuji, Kurumi Taniguchi, Yasuko Kitagishi, Satoru Matsuda,
Epigenetics contains various mechanisms by which cells employ to regulate the transcription of many DNAs. Histone acetylation is an obvious example of the epigenetic mechanism regulating the expression of several genes by changing chromatin accessibility. Histone deacetylases (HDACs) are a class of enzymes that play a critical role in the epigenetic regulation by deacetylation of histone proteins. Inhibitors of the histone deacetylase could result in hyperacetylation of histones, which eventually ...
Tópico(s): Epigenetics and DNA Methylation
2021 - | Oxygen
Masaharu Tsuji, Kanako Matsuda, Mayu Tanaka, Satsuki Kuboyama, Keiko Uto, Nozomi Wada, Hirofumi Kawazumi, Takeshi Tsuji, Hiroki Ago, Jun‐ichiro Hayashi,
Abstract A comparative study was carried out on the degradation of methyl orange (MO) by TiO 2 and Au/TiO 2 photocatalysts in neutral and acidic solutions. Au/TiO 2 photocatalysts with an Au : Ti atomic ratio of 1.5±0.1% : 98.5±0.1% were prepared by using a microwave‐polyol method in the presence of P25 TiO 2 . Initial degradation rates of MO by TiO 2 and Au/TiO 2 were 0.13 and 0.22 min −1 at pH 7, whereas they increased to 0.96 and 3.06 min −1 at pH 2, respectively. These results indicate that the MO degradation ...
Tópico(s): Advanced Nanomaterials in Catalysis
2018 - Wiley | ChemistrySelect
Nozomi Eto, Junichi Yamazoe, Akiko Tsuji, Naohisa Wada, Noriaki Ikeda,
Forensic dentistry identifies deceased individuals by comparing postmortem dental charts, oral-cavity pictures and dental X-ray images with antemortem records. However, conventional forensic dentistry methods are time-consuming and thus unable to rapidly identify large numbers of victims following a large-scale disaster.Our goal is to automate the dental filing process by using intraoral scanner images. In this study, we generated and evaluated an artificial intelligence-based algorithm that classified ...
Tópico(s): Endodontics and Root Canal Treatments
2022 - Public Library of Science | PLoS ONE
Nozomi Nagase, Yuka Ikeda, Ai Tsuji, Yasuko Kitagishi, Satoru Matsuda,
Diabetic nephropathy (DN) is a major cause of end-stage renal disease, and therapeutic options for preventing its progression are insufficient. The number of patients with DN has been increasing in Asian countries because of westernization of dietary lifestyle, which may be associated with the following changes in gut microbiota. Alterations in the gut microbiota composition can lead to an imbalanced gastrointestinal environment that promotes abnormal production of metabolites and/or inflammatory ...
Tópico(s): Tryptophan and brain disorders
2022 - | World Journal of Diabetes
Kazunari Nakahara, Yosuke Michikawa, Ryo Morita, Keigo Suetani, Nozomi Morita, Junya Sato, K Tsuji, Hiroki Ikeda, Kotaro Matsunaga, Tsunamasa Watanabe, Nobuyuki Matsumoto, Shinjiro Kobayashi, Takehito Otsubo, Fumio Itoh,
Background and study aims Biliary plastic stents are generally substituted for gallbladder stents in endoscopic transpapillary gallbladder stenting (EGBS), there is no sufficient evidence about what type of plastic stent is suitable. We examined outcomes of EGBS using standard biliary stents and a novel stent for acute cholecystitis and evaluated the efficacy of the novel stent. Patients and methods Seventy patients with acute cholecystitis in whom EGBS was performed were evaluated retrospectively. ...
Tópico(s): Cholangiocarcinoma and Gallbladder Cancer Studies
2019 - Thieme Medical Publishers (Germany) | Endoscopy International Open
Nozomi Matsuda, Atsuko Taki, Atsumi Tsuji‐Hosokawa, Keisuke Nakajima, Kei Takasawa, Chikako Morioka, Yoshihiro Minosaki, Kikuko Oku, Kenichi Kashimada, Tomohiro Morio,
Factors affecting growth and development in extremely low birth weight infants (ELBWIs) born small for gestational age (SGA) have not been precisely elucidated. We performed a retrospective analysis of ELBWIs born SGA who were treated in the neonatal intensive care unit of Kawaguchi Municipal Medical Centre, Japan. A total 244 ELBWIs were born from 2003 to 2010, and 31 were born with weight and height below the 10th percentile for their gestational age. Among the 31 ELBWIs born SGA, we excluded 9 ...
Tópico(s): Infant Nutrition and Health
2018 - Japanese Society for Pediatric Endocrinology | Clinical Pediatric Endocrinology
Nozomi Ahiko, Yoshiyuki Baba, Michiko Tsuji, Reiko Horikawa, Keiji Moriyama,
ABSTRACT Turner syndrome is associated with an X chromosome abnormality in women and is characterized by infantilism, congenital webbed neck, and cubitus valgus. The aim of this study was to determine the maxillofacial morphology and oral characteristics of Japanese girls (mean age, 8.5 years) with Turner syndrome and early mixed dentition. Lateral cephalograms obtained at the first visit were used to analyze maxillofacial morphology. Oral characteristics were identified using orthopantomograms, ...
Tópico(s): Oral and Maxillofacial Pathology
2018 - Wiley | Congenital Anomalies
Shigeru Takishima, Keisuke Nakajima, Risa Nomura, Atsumi Tsuji‐Hosokawa, Nozomi Matsuda, Yohei Matsubara, Makoto Ono, K Miyai, Kei Takasawa, Tomohiro Morio, Yukihiro Hasegawa, Kenichi Kashimada,
21-hydroxylase deficiency (21-OHD) is the most common type of congenital adrenal hyperplasia. In addition to the clinical problems caused by adrenal insufficiency and androgen excess, a risk for obesity and metabolic syndrome during young adulthood is a major ramification of the disease. Although glucocorticoid therapy is very likely to be one of the contributory factors, the precise causes of the metabolic status of adult 21-OHD patients remain to be clarified. Previously we reported that 21-OHD ...
Tópico(s): Growth Hormone and Insulin-like Growth Factors
2016 - Japan Endocrine Society | Endocrine Journal
Kazunari Nakahara, Yosuke Michikawa, Ryo Morita, Keigo Suetani, Nozomi Morita, Junya Sato, K Tsuji, Hiroki Ikeda, Kotaro Matsunaga, Tsunamasa Watanabe, Nobuyuki Matsumoto, Shinjiro Kobayashi, Takehito Otsubo, Fumio Itoh,
Tópico(s): Cholangiocarcinoma and Gallbladder Cancer Studies
2018 - Springer Science+Business Media | Digestive Diseases and Sciences
Kurumi Taniguchi, Yuka Ikeda, Nozomi Nagase, Ai Tsuji, Yasuko Kitagishi, Satoru Matsuda,
<abstract> <p>Psychiatric disorders may extremely impair the quality of life with patients and are important reasons of social disability. Several data have shown that psychiatric disorders are associated with an altered composition of gut microbiota. Dietary intake could determine the microbiota, which contribute to produce various metabolites of fermentation such as short chain fatty acids. Some of the metabolites could result in epigenetic alterations leading to the disease susceptibility. ...
Tópico(s): Gut microbiota and health
2021 - AIMS Press | AIMS bioengineering
Nozomi Ahiko, Yoshiyuki Baba, Michiko Tsuji, Shoichi Suzuki, Tsuyoshi Kaneko, Junko Kindaichi, Keiji Moriyama,
Objective : Hemifacial microsomia (HFM) is a congenital anomaly characterized by unilateral underdevelopment of the mandible and ear. This study was conducted to characterize maxillofacial morphology and dental development in Japanese patients with HFM. Design : This is a retrospective hospital-based study. Patients : The subject population comprised 12 boys and 12 girls (average age, 9.3 years) diagnosed with HFM. Main Outcome Measures : We used posteroanterior (PA) and lateral cephalograms obtained at the ...
Tópico(s): Congenital limb and hand anomalies
2014 - SAGE Publishing | The Cleft Palate-Craniofacial Journal
Toshifumi Tada, Takashi Kumada, Hidenori Toyoda, Yasuhiro Sone, Yuji Kaneoka, Atsuyuki Maeda, Seiji Okuda, Katsuhiko Otobe, Nozomi Tsuji,
To clarify the value of gray-scale ultrasound (US) combined with contrast-enhanced US (CEUS) with perflubutane in diagnosing early hepatocellular carcinoma (HCC).A total of 57 surgically resected, well differentiated HCCs were analyzed. Hepatocellular carcinomas were macroscopically diagnosed as vaguely nodular or distinctly nodular types, which correspond to early HCC or progressed HCC, respectively. Gray-scale US findings were evaluated in terms of shape (round or roundish, or irregular), border and ...
Tópico(s): Liver Disease and Transplantation
2016 - Wiley | Hepatology Research
Atsumi Tsuji‐Hosokawa, Nozomi Matsuda, Kenji Kurosawa, Kenichi Kashimada, Tomohiro Morio,
MECP2 duplication syndrome, which is caused by duplication of part of the Xq28 region containing the MECP2 gene, causes intellectual disability and mild dysmorphic features in males. To date, precocious puberty has not been reported as a clinical feature of MECP2 duplication syndrome.A 6-year-old male with severe intellectual disability was referred because of growth acceleration and precocious puberty. We checked his hormonal profile and conducted imaging studies and an array comparative genomic ...
Tópico(s): Congenital heart defects research
2016 - Karger Publishers | Hormone Research in Paediatrics
Yoshifumi Noda, Satoshi Goshima, Kazuto Kozaka, Norihide Yoneda, Nozomi Mizuno, Akiko Kato, Keita Fujimoto, Yusuke Tsuji, Toshiharu Miyoshi, Hiroshi Kawada, Nobuyuki Kawai, Yukichi Tanahashi, Masayuki Matsuo,
To determine the optimal window settings for monochromatic images with various energy levels in single-source dual-energy computed tomography (DECT) of the abdomen.Two hundred consecutive patients underwent contrast-enhanced DECT to screen tumor metastases and/or recurrences after surgery for malignant tumors. Two independent radiologists reviewed eight energy levels (40, 45, 50, 55, 60, 65, 70, and 75 kilo-electron volts [keV]) of the portal venous phase monochromatic images. For each keV image, the ...
Tópico(s): Medical Imaging Techniques and Applications
2018 - Elsevier BV | European Journal of Radiology
Nozomi Iwanaga, Kohei Harada, Yoshika Tsuji, Chieko Kawahara, Kazuhiro Kurohama, Yasumori Izumi, Shinichiro Yoshida, Keita Fujikawa, Masahiro Ito, Atsushi Kawakami, Kiyoshi Migita,
A 25-year-old woman diagnosed 1 year earlier with Primary Sjogren's syndrome was admitted to a nearby hospital with fever of unknown origin. Examination revealed anasarca, systemic lymphadenopathy, hepatosplenomegaly and high C-reactive protein level. The patient's symptoms were initially suspected to be caused by severe bacterial infection with Sjogren's syndrome flare. She was given antibiotics and prednisolone (PSL) at 50 mg/day. However, the patient developed anemia and thrombocytopenia and was ...
Tópico(s): Vascular anomalies and interventions
2016 - Japanese Society for Clinical Immunology | Japanese Journal of Clinical Immunology
Kousuke Tsuji, Takuma Asayama, Nozomi Shiraki, Shota Inoue, Erina Okuda, Chizuru Hayashi, Kazuma Nishida, Hiroshi Hasegawa, Emiko Harada,
Many aquatic plants act as biosorbents, removing and recovering metals from the environment. To assess the biosorbent activity of Egeria densa, a submerged freshwater macrophyte, plants were collected monthly from a circular drainage area in Lake Biwa basin and the Mn concentrations of the plants were analysed. Mn concentrations in these plants were generally above those of terrestrial hyperaccumulators, and were markedly higher in spring and summer than in autumn. Mn concentrations were much lower ...
Tópico(s): Paleontology and Stratigraphy of Fossils
2017 - Wiley | Plant Cell & Environment
Kazuya Honda, Nozomi Iwanaga, Yasumori Izumi, Yoshika Tsuji, Chieko Kawahara, Toru Michitsuji, Shuntaro Higashi, Atsushi Kawakami, Kiyoshi Migita,
We report a case of reactive arthritis (ReA) triggered by Yersinia enterocolitica enteritis. A 24-year-old Japanese man developed polyarthritis in the lower limbs. Two weeks prior to these symptoms, he noted diarrhea, right lower abdominal pain and a fever. Y. enterocolitica was not isolated from a stool culture; however, he was diagnosed with ReA based on the colonoscopic findings of a high anti-Y. enterocolitica antibody titer and HLA-B27 antigen positivity. Following treatment with methotrexate ...
Tópico(s): Pharmacological Effects of Natural Compounds
2017 - The Japanese Society of Internal Medicine | Internal Medicine
Hiroki Mukoyama, Mirei Shirakashi, Nozomi Tanaka, Takeshi Iwasaki, Toshiki Nakajima, Hideo Onizawa, Hideaki Tsuji, Koji Kitagori, Shuji Akizuki, Ran Nakashima, Kosaku Murakami, Masao Tanaka, Akio Morinobu, Hajime Yoshifuji,
Pulmonary artery involvement (PAI) in Takayasu arteritis (TAK) can lead to severe complications, but the relationship between the two has not been fully clarified.We retrospectively investigated 166 consecutive patients with TAK who attended Kyoto University Hospital from 1997 to 2018. The demographic data, clinical symptoms and signs, comorbidities, treatments, and imaging findings were compared between patients with and without PAI. TAK was diagnosed based on the American College of Rheumatology ...
Tópico(s): Amyloidosis: Diagnosis, Treatment, Outcomes
2021 - BioMed Central | Arthritis Research & Therapy
Fumihiko Toyoda, Yoshiaki Tanaka, Ayumi Ota, Machiko Shimmura, Nozomi Kinoshita, Hiroko Takano, Takafumi Matsumoto, Jun‐ichi Tsuji, Akihiro Kakehashi,
Purpose . To evaluate the effect of ranirestat, a new aldose reductase inhibitor (ARI), on diabetic retinopathy (DR) in Spontaneously Diabetic Torii (SDT) rats. Methods . The animals were divided into six groups, normal Sprague-Dawley rats ( n = 8 ) , untreated SDT rats ( n = 9 ) , ranirestat-treated SDT rats (0.1, 1.0, and 10 mg/kg/day, n = 7 , 8 , and 6 , resp.), and epalrestat-treated SDT rats (100 mg/kg/day, n = 7 ) . Treated rats received oral ranirestat or epalrestat once daily for 40 weeks after the onset of diabetes. After the ...
Tópico(s): Adenosine and Purinergic Signaling
2014 - Hindawi Publishing Corporation | Journal of Diabetes Research
Ryuta Shigefuku, Tsunamasa Watanabe, Nobuhiro Hattori, Hiroki Ikeda, Kotaro Matsunaga, Nobuyuki Matsumoto, Takuya Ehira, Tatsuya Suzuki, Ryosuke Oumi, Yosuke Igarashi, K Tsuji, Nozomi Morita, Ryo Morita, Yosuke Michikawa, Kazunari Nakahara, Keigo Suetani, Hiroyasu Nakano, Tetsuya Hiraishi, Y. Noguchi, Hideaki Takahashi, Toshiya Ishii, Hiroyuki Kunishima, Chiaki Okuse, Michihiro Suzuki, Fumio Itoh,
当院において過去20年間に経験した肝膿瘍153例の病原微生物,背景疾患,臨床経過に関して,後方視的に検討した.化膿性肝膿瘍ではアメーバ性肝膿瘍と比較し,糖尿病,悪性疾患,胆道系疾患が有意に高率であった.化膿性肝膿瘍の原因菌は,Klebsiella pneumoniae,Escherichia coliの順に多い.血液培養の検出率は44%であるのに対して,膿瘍培養の検出率は83%と高率であった.抗菌薬に抵抗性を有する原因菌の頻度は少なかった.アメーバ性肝膿瘍では,常用飲酒家が多いことが特徴であった.また感染経路不明の無症候性囊子保有者における免疫抑制療法中の発症があるため注意を要する.肝膿瘍は重症化する例があるため,早期に膿瘍培養を行い,適切に治療することが重要である.中でも,悪性疾患や複数細菌の混合感染例,多臓器に膿瘍形成を有する症例では重症化することがあり留意すべきである.
Tópico(s): Diagnosis and treatment of tuberculosis
2018 - The Japan Society of Hepatology | Kanzo
Yoshika Tsuji, Nozomi Iwanaga, Anna Adachi, Kinuyo Tsunozaki, Yasumori Izumi, Yuji Moriwaki, Kazuhiro Kurohama, Masahiro Ito, Atsushi Kawakami, Kiyoshi Migita,
We report a 64-year-old female case of intractable adult-onset Still's disease (AOSD). Initial high-dose steroid therapy combined with cyclosporin A was ineffective against macrophage-activation syndrome (MAS), which was accompanied by the systemic type of AOSD. Treatment for MAS with intravenous cyclophosphamide resulted in remission of AOSD and a reduction in the high doses of steroids. Efficacy of biologics against MAS in AOSD is unclear. Cyclophosphamide, a conventional cytotoxic agent, should ...
Tópico(s): Family and Disability Support Research
2015 - Hindawi Publishing Corporation | Case Reports in Rheumatology
Ayumi Ota, Akihiro Kakehashi, Fumihiko Toyoda, Nozomi Kinoshita, Machiko Shinmura, Hiroko Takano, Hiroto Obata, Takafumi Matsumoto, Jun‐ichi Tsuji, Yoh Dobashi, Wilfred Y. Fujimoto, Masanobu Kawakami, Yasunori Kanazawa,
We evaluated ranirestat, an aldose reductase inhibitor, in diabetic cataract and neuropathy (DN) in spontaneously diabetic Torii (SDT) rats compared with epalrestat, the positive control. Animals were divided into groups and treated once daily with oral ranirestat (0.1, 1.0, 10 mg/kg) or epalrestat (100 mg/kg) for 40 weeks, normal Sprague-Dawley rats, and untreated SDT rats. Lens opacification was scored from 0 (normal) to 3 (mature cataract). The combined scores (0-6) from both lenses represented the ...
Tópico(s): Connexins and lens biology
2013 - Hindawi Publishing Corporation | Journal of Diabetes Research
Fumihito Ushiyama, Hajime Takashima, Yohei Matsuda, Yuya Ogata, Naoki Sasamoto, Risa Kurimoto-Tsuruta, Kaori Ueki, Nozomi Tanaka-Yamamoto, Mayumi Endo, Masashi Mima, Kiyoko Fujita, Iichiro Takata, Satoshi Tsuji, Haruhiro Yamashita, Hirotoshi Okumura, Katsumasa Otake, Hiroyuki Sugiyama,
Infectious diseases caused by resistant Gram-negative bacteria have become a serious problem, and the development of therapeutic drugs with a novel mechanism of action and that do not exhibit cross-resistance with existing drugs has been earnestly desired. UDP-3-O-acyl-N-acetylglucosamine deacetylase (LpxC) is a drug target that has been studied for a long time. However, no LpxC inhibitors are available on the market at present. In this study, we sought to create a new antibacterial agent without ...
Tópico(s): Pneumonia and Respiratory Infections
2020 - Elsevier BV | Bioorganic & Medicinal Chemistry
Ikuo Kawasaki, Kazuya Tsunoda, Tomoko Tsuji, Tomoko Yamaguchi, Hiroki Shibuta, Nozomi Uchida, Masayuki Yamashita, Shunsaku Ohta,
A novel task-specific ionic ligand with an imidazolium salt moiety was synthesized, and its catalytic ability and recyclability for asymmetric transfer hydrogenation of acetophenone derivatives with a formic acid–triethylamine azeotropic mixture in an ionic liquid [bmim][PF6] was examined.
Tópico(s): Carbon dioxide utilization in catalysis
2005 - Royal Society of Chemistry | Chemical Communications