Afonso Maria da Silva Moreira, Maria José Diógenes, Alexandre de Mendonça, Nuno Lunet, Henrique Barros,
Cocoa-related products like chocolate have taken an important place in our food habits and culture. In this work, we aim to examine the relationship between chocolate consumption and cognitive decline in an elderly cognitively healthy population. In the present longitudinal prospective study, a coh ort of 531 participants aged 65 and over with normal Mini-Mental State Examination (MMSE; median 28) was selected. The median follow-up was 48 months. Dietary habits were evaluated at baseline. The MMSE ...
Tópico(s): Antioxidant Activity and Oxidative Stress
2016 - IOS Press | Journal of Alzheimer s Disease
Luís Fonseca, Joaquim Duarte, Álvaro Machado, Ioannis Sotiropoulos, Carlos Augusto de Mendonça Lima, Nuno Sousa,
International Journal of Geriatric PsychiatryVolume 29, Issue 2 p. 217-218 Letter to the Editor Suicidal behaviour in frontotemporal dementia patients—a retrospective study Correction(s) for this article Erratum: Suicidal behaviour in frontotemporal dementia patients—a retrospective study Luís Fonseca, Joaquim Duarte, Álvaro Machado, Ioannis Sotiropoulos, Carlos Lima, Nuno Sousa, Volume 29Issue 8International Journal of Geriatric Psychiatry pages: 880-880 First Published online: July 16, 2014 Luís ...
Tópico(s): Bipolar Disorder and Treatment
2014 - Wiley | International Journal of Geriatric Psychiatry
Eugenio Mercuri, Francesco Muntoni, Giovanni Baranello, Riccardo Masson, Odile Boespflug‐Tanguy, Claudio Bruno, Stefania Corti, Aurore Daron, Nicolas Deconinck, Laurent Servais, Volker Straub, Haojun Ouyang, Deepa H. Chand, Sitra Tauscher‐Wisniewski, Nuno Mendonça, Arseniy Lavrov, Andrea Seferian, S. De Lucia, Shotaro Tachibana, A. Jollet, S. Mouffak, Marina Pedemonte, Noemi Brolatti, Simone Morando, Arnaud Vanlander, Elke De Vos, Valentine Tahon, Alessandra Govoni, Francesca Magri, Giacomo P. Comi, Michaela Foà, Valeria Parente, L. Buscemi, Fabian Dal Farra, Olga Schneider, Anovick Jonas, A.C. Defeldre, Emanuela Pagliano, Riccardo Zanin, Maria Teresa Arnoldi, Veronica Schembri, Marina Solé, Anna Mandelli, Maria Carmela Pera, Laura Antonaci, Giorgia Coratti, Rita De Sanctis, Marika Pane, Mariacristina Scoto, Katie Groves, Lisa Edel, François Abel, H. van Ruiten, Robert Muni Lofra, E. T. Thompson,
Background Spinal muscular atrophy is a rare, autosomal recessive, neuromuscular disease caused by biallelic loss of the survival motor neuron 1 (SMN1) gene, resulting in motor neuron dysfunction. In this STR1VE-EU study, we aimed to evaluate the safety and efficacy of onasemnogene abeparvovec gene replacement therapy in infants with spinal muscular atrophy type 1, using broader eligibility criteria than those used in STR1VE-US. Methods STR1VE-EU was a multicentre, single-arm, single-dose, open-label ...
Tópico(s): RNA modifications and cancer
2021 - Elsevier BV | The Lancet Neurology
Catarina Duarte Santos, Nuno Lunet, Ana Azevedo, Alexandre de Mendonça, Karen Ritchie, Henrique Barros,
Alzheimer's disease has emerged in recent decades as a major health problem and the role of lifestyles in the modulation of risk has been increasingly recognized. Recent epidemiological studies suggest a protective effect for caffeine intake in dementia. We aimed to quantify the association between caffeine dietary intake and cognitive decline, in a cohort of adults living in Porto. A cohort of 648 subjects aged > or =65 years was recruited between 1999-2003. Follow-up evaluation (2005-2008) was carried ...
Tópico(s): Tea Polyphenols and Effects
2010 - IOS Press | Journal of Alzheimer s Disease
Vanessa Silva, Luciana Mayara Mendonça de Almeida, Vânia Gaio, Nuno Cerca, Vera Manageiro, Manuela Caniça, José Luís Capelo, Gilberto Igrejas, Patrícia Poeta,
Methicillin-resistant Staphylococcus aureus (MRSA) is one of the main pathogens causing chronic infections, mainly due to its capacity to form biofilms. However, the mechanisms underlying the biofilm formation of MRSA strains from different types of human infections are not fully understood. MRSA strains isolated from distinct human infections were characterized aiming to determine their biofilm-forming capacity, the biofilm resistance to conventional antibiotics and the prevalence of biofilm-related ...
Tópico(s): Bacterial Identification and Susceptibility Testing
2021 - Multidisciplinary Digital Publishing Institute | Pathogens
Liliana Mendonça, João Nuno Moreira, Maria C. Pedroso de Lima, Sérgio Simões,
Abstract Chronic myeloid leukemia (CML) is triggered by the BCR‐ABL oncogene. Imatinib is the first‐line treatment of CML; however imatinib resistance and intolerance have been detected in many patients. Therefore, new therapeutic approaches are required. The present work aimed at the development and application of transferrin receptor (TrfR) targeted liposomes co‐encapsulating anti‐ BCR‐ABL siRNA and imatinib at different molar ratios. The encapsulation yields and drug loading of each molecule was ...
Tópico(s): Monoclonal and Polyclonal Antibodies Research
2010 - Wiley | Biotechnology and Bioengineering
Nádia Lago Costa, Rosário Silva, Maria Cristina de Mendonça, Francisco Gonçalves, Duarte Nuno Vieira, Helena M. Teixeira,
This study presents the prevalence of ethanol and illicit drugs in fatal road traffic accident victims in the Centre of Portugal between January 1990 and December 2007. Among the violent deaths, road traffic accidents presented the highest percentage (around 35%; n=3095), but decreasing throughout the years. Accidents were preponderant in males (about 80%; n=2402), between 21 and 30 years-old. Accidents involving drivers (55%; n=1310) were of the most common, being the car the main vehicle (45%), followed ...
Tópico(s): Cardiac Arrest and Resuscitation
2011 - Elsevier BV | Forensic Science International
Francisco Ruas, Maria Cristina de Mendonça, Francisco Gonçalves, Duarte Nuno Vieira, Helena M. Teixeira,
This study presents the epidemiology and the postmortem forensic aspects in cases with a carboxihemoglobin (COHb) analysis, from autopsies performed at the Forensic Pathology Department of the Centre Branch of the National Institute of Legal Medicine and Forensic Sciences of Portugal. Between January 2000 and December 2010, 69 COHb analyses were requested in our institution. In approximately 70% of the situations, circumstantial information included a Carbon Monoxide (CO) source at the death scene. ...
Tópico(s): Burn Injury Management and Outcomes
2014 - Elsevier BV | Journal of Forensic and Legal Medicine
Daniel Dias, Maria Cristina de Mendonça, Francisco Gonçalves, Duarte Nuno Vieira, Helena M. Teixeira,
As one of the more specific and distinctive problems of human beings, suicide has been investigated with increasing attention all over the world. Several risk factors have been described as well as limitations arising from their study. The World Health Organization estimates that this scourge affects one million people annually, which corresponds to one death every 40s worldwide. According to recent studies, Portugal, despite the good rates (10 suicide deaths per 100,000 inhabitants), had shown an ...
Tópico(s): Homicide, Infanticide, and Child Abuse
2013 - Elsevier BV | Forensic Science International
Álvaro Carvalho, Ana Rita Henriques, Paula Queirós, Joana Rodrigues, Nuno Mendonça, Ana Maria Rodrigues, Helena Canhão, Germano de Sousa, Francisco Antunes, Miguel Guimarães,
Background and aim The kinetics of antibody production in response to coronavirus disease 2019 (COVID-19) infection is not well-defined yet. This study aimed to evaluate the antibody responses to SARS-CoV-2 and its dynamics during 9-months in a cohort of patients infected during the first phase of the pandemic. As a secondary aim, it was intended to evaluate the factors associated with different concentrations of IgG antibodies. Methods A prospective cohort study was conducted from June 2020 to January ...
Tópico(s): Diabetes and associated disorders
2023 - Frontiers Media | Frontiers in Public Health
Nuno Mendonça, Alan Flores, Jorge Pagola, Marta Rubiera, David Rodríguez‐Luna, Maria Angels de Miquel, Pere Cardona, Helena Quesada, Paloma Mora, José Álvarez‐Sabín, Carlos A. Molina, Marc Ribó,
ABSTRACT BACKGROUND AND PURPOSE Recent reports have indicated that mechanical thrombectomy may have the potential to treat acute ischemic stroke. This study aims to describe the safety and effectiveness of Trevo Retriever, using Stentriever technology, in revascularization of patients with acute ischemic stroke. METHODS Prospective study evaluating the clinical, radiological, and functional outcome of 13 patients with an angiographically verified occlusion of the anterior cerebral circulation. All ...
Tópico(s): Stroke Rehabilitation and Recovery
2011 - Wiley | Journal of Neuroimaging
Nuno Mendonça, Alan Flores, Jorge Pagola, Marta Rubiera, David Rodríguez‐Luna, Maria Angels de Miquel, Pere Cardona, Helena Quesada, Paloma Mora, José Álvarez‐Sabín, Carlos A. Molina, Marc Ribó,
ABSTRACT BACKGROUND AND PURPOSE Recent reports have indicated that mechanical thrombectomy may have potential to treat acute ischemic stroke. However, few comparative studies of neurothrombectomy devices are reported. This study aims to compare the safety and effectiveness of two retrievable stent systems in acute ischemic stroke patients. METHODS A prospective study comparing the clinical, radiological, and functional outcome of 33 patients with an angiographically verified occlusion of the anterior ...
Tópico(s): Stroke Rehabilitation and Recovery
2012 - Wiley | Journal of Neuroimaging
Teresa Madeira, Catarina Peixoto-Plácido, Beatriz Goulão, Nuno Mendonça, Violeta Alarcão, Nuno C. Santos, Rita Machado de Oliveira, Agneta Yngve, Asta Bye, Astrid Bergland, Carla Lopes, Paulo Nicola, Osvaldo Santos, J. Gorjão Clara,
Worldwide we are facing a serious demographic challenge due to the dramatic growth of the population over 60 years. It is expected that the proportion of this population will nearly double from 12 to 22 %, between 2015 and 2050. This demographic shift comes with major health and socio-economic concerns. Nutrition is a fundamental determinant of both health and disease and its role in extending a healthy lifespan is the object of considerable research. Notably, malnutrition is one of the main threats ...
Tópico(s): Nutritional Studies and Diet
2016 - BioMed Central | BMC Geriatrics
Gennaro Perrone, Mario Giuffrida, Fikri M. Abu‐Zidan, Vitor Favali Kruger, Marco Livrini, Gabriele Luciano Petracca, G. Rossi, Antonio Tarasconi, Brian Tian, Elena Bonati, Ricardo Mentz, Federico N. Mazzini, Juan Pablo Campana, Elisabeth Gasser, Reinhold Kafka‐Ritsch, Daniel Moritz Felsenreich, Christopher Dawoud, Stefan Riss, Carlos Augusto Gomes, Felipe Couto Gomes, Ricardo Alessandro Teixeira Gonzaga, Cassio Alfred Brattig Canton, Bruno M. Pereira, Gustavo Pereira Fraga, Leticia Gonçalves Zem, Vinicius Cordeiro-Fonseca, Renato de Mesquita Tauil, Boyko Atanasov, Nikolay Belev, Nikola Kovachev, Libardo J. Meléndez, Ana Dimova, Stefan Dimov, Zdravko Zelić, Goran Augustin, Branko Bogdanić, Trpimir Morić, Élie Chouillard, Melinda Bajul, Belinda De Simone, Yves Panís, Francesco Esposito, Margherita Notarnicola, Lelde Lauka, Anna Adele Fabbri, Hassen Hentati, Iskander Fnaiech, Venara Aurélien, M. Bougard, Maxime Roulet, Zaza Demetrashvili, Irakli Pipia, G Merabishvili, Konstantinos Bouliaris, George Koukoulis, Christos Doudakmanis, Sofia Xenaki, Emmanuel Chrysos, Stamatios Kokkinakis, Pantelis Vassiliu, Nikolaos V. Michalopoulos, Ioannis Margaris, Aristotelis Kechagias, Konstantinos Avgerinos, Jevgeni Katunin, Eftychios Lostoridis, Eleni-Aikaterini Nagorni, Antonio Pujante, Francesk Mulita, Ioannis Maroulis, Michail Vailas, Athanasios Marinis, Ioannis Siannis, Eirini Bourbouteli, Dimitrios K. Manatakis, Nikolaos Tasis, Vasileios Acheimastos, Sotiropoulou Maria, Kapiris Stylianos, Harilaos Kuzeridis, Dimitrios Korkolis, Evangelos Fradelos, George Kavalieratos, Thalia Petropoulou, Andreas Polydorou, Ioannis Papacostantinou, Tania Triantafyllou, Despina Kimpizi, Dimitrios Theodorou, Konstantinos Toutouzas, Alexandros Chamzin, Maximos Frountzas, Dimitriοs Schizas, Ioannis Karavokyros, Athanasios Syllaios, Alexandros Charalabopoulos, Maria Boura, Efstratia Baili, Orestis Ioannidis, Lydia Loutzidou, Elissavet Anestiadou, Ioannis Tsouknidas, Georgios Petrakis, Eleni Polenta, Lovenish Bains, Rahul Gupta, Sudhir Singh, Archana Khanduri, Miklosh Bala, Asaf Kedar, Marcello Pisano, Mauro Podda, Adolfo Pisanu, Gennaro Martines, Giuseppe Trigiante, Giuliano Lantone, Antonino Agrusa, Giuseppe Di Buono, Salvatore Buscemi, Massimiliano Veroux, Rossella Gioco, G Veroux, Luigi Oragano, Sandro Zonta, Federico Lovisetto, Carlo V. Feo, Antonio Pesce, Nicolò Fabbri, G Lantone, Fabio Marino, Fabrizio Perrone, Leonardo Vincenti, Vincenzo Papagni, Arcangelo Picciariello, Stefano Rossi, Biagio Picardi, Simone Rossi Del Monte, Diego Visconti, Giulia Osella, Luca Petruzzelli, Giusto Pignata, Jacopo Andreuccetti, Rossella D’Alessio, Massimo Buonfantino, Eleonora Guaitoli, S. Spinelli, Gianluca M. Sampietro, Carlo Corbellini, L. Lorusso, Alice Frontali, Isabella Pezzoli, Alessandro Bonomi, Andréa Chierici, Christian Cotsoglou, Giuseppe Manca, Antonella Delvecchio, Nicola Musa, Massimiliano Casati, Laface Letizia, Emmanuele Abate, Giorgio Ercolani, Fabrizio D’Acapito, Leonardo Solaini, Gianluca Guercioni, Simone Cicconi, Diego Sasia, Felice Borghi, Giorgio Giraudo, Giuseppe Sena, Pasquale Castaldo, Eugenia Cardamone, Giuseppe Portale, Matteo Zuin, Ylenia Camilla Spolverato, Marialusia Esposito, R. Isernia, Maria Di Salvo, Romina Manunza, Giuseppe Esposito, Marcello Agus, Emanuele Asti, Daniele Bernardi, Tommaso Panici Tonucci, Davide Luppi, Massimiliano Casadei, Stefano Bonilauri, Angela Pezzolla, Annunziata Panebianco, Rita Laforgia, Maurizio De Luca, Monica Zese, Dario Parini, Elio Jovine, Giuseppina De Sario, Raffaele Lombardi, Giovanni Aprea, Giuseppe Palomba, Marianna Capuano, Giulio Argenio, Gianluca Orio, Mariano Fortunato Armellino, Marina Troian, Martina Guerra, Carlo Nagliati, Alan Biloslavo, Paola Germani, Giada Aizza, Igor Monsellato, Ali Chaouki Chahrour, Gabriele Anania, Cristina Bombardini, Francesco Bagolini, Gabriele Sganga, Pietro Fransvea, Valentina Bianchi, Paolo Boati, Francesco Ferrara, Francesco Palmieri, Pasquale Cianci, Domenico Gattulli, Enrico Restini, Nicola Cillara, Alessandro Cannavera, Gabriela Elisa Nita, Jlenia Sarnari, Francesco Roscio, Federico Clerici, Ildo Scandroglio, Stefano Berti, Alessandro Cadeo, Alice Filippelli, Luigi Conti, Carmine Grassi, G Cattaneo, Marina Pighin, Davide Papis, Giovanni Gambino, V. Bertino, Domenico Schifano, Daniela Prando, Luisella Fogato, Fabio Cavallo, Luca Ansaloni, Roberto Picheo, Nicholas Pontarolo, Norma Depalma, Marcello Spampinato, Stefano D’Ugo, L Lepre, M Capponi, Rossella D. Campa, Giuliano Sarro, Vincenza Paola Dinuzzi, Stefano Olmi, Matteo Uccelli, Davide Ferrari, Marco Inama, Gianluigi Moretto, Michele Fontana, Francesco Favi, Erika Picariello, Alessia Rampini, Andrea Barberis, Antonio Azzinnaro, Alba Oliva, Luigi Totaro, Ilaria Benzoni, Valerio Ranieri, Gabriella Teresa Capolupo, Filippo Carannante, Marco Caricato, Maurizio Ronconi, Silvia Casiraghi, Giovanni Casole, D Pantalone, Giovanni Alemanno, Maximilian Scheiterle, Marco Ceresoli, Marco Cereda, Chiara Fumagalli, Federico Zanzi, Stefano Bolzon, Enrico Guerra, Francesca Lecchi, P Cellerino, Antonella Ardito, Rosa Teresa Scaramuzzo, Andrea Balla, Pasquale Lepiane, Nicola Tartaglia, Antonio Ambrosi, Giovanna Pavone, Gian Marco Palini, Simone Veneroni, Gianluca Garulli, Claudio Ricci,
Abstract Background Literature suggests colonic resection and primary anastomosis (RPA) instead of Hartmann’s procedure (HP) for the treatment of left-sided colonic emergencies. We aim to evaluate the surgical options globally used to treat patients with acute left-sided colonic emergencies and the factors that leading to the choice of treatment, comparing HP and RPA. Methods This is a prospective, international, multicenter, observational study registered on ClinicalTrials.gov. A total 1215 patients ...
BioMed Central
Liliana Mendonça, Filipe Firmino, João Nuno Moreira, Maria C. Pedroso de Lima, Sérgio Simões,
The present work aimed at the development and application of transferrin receptor (TrfR)-targeted sterically stabilized liposomes encapsulating anti-BCR-ABL siRNA or asODN. Transferrin was coupled to the surface of liposomes encapsulating siRNA or asODN through the postinsertion method. Cell association and internalization were assessed by flow cytometry and confocal microscopy, respectively. BCR-ABL mRNA and Bcr-Abl protein levels were evaluated by qRT-PCR and Western blot, respectively. Cell viability ...
Tópico(s): DNA and Nucleic Acid Chemistry
2009 - American Chemical Society | Bioconjugate Chemistry
Sérgio L. Costa, João Pedro Mendonça, Nuno Peixinho,
In this study the crashworthy performance of an ultimate safety toe cap model made of high-strength steel was evaluated. The structural response to impact loading conditions under normative requirements was properly related to the potential of lightweight design for a significant thickness reduction. Two grades of fully martensitic steels were selected and numerical models modelling extensive plastic deformation and strain-rate dependence were performed. The mathematical description of the impact ...
Tópico(s): Cellular and Composite Structures
2015 - Elsevier BV | Materials & Design
Frederico Simões do Couto, Nuno Lunet, Sandra Ginó, Catarina Chester, V. Freitas, Carolina Maruta, Maria Luísa Figueira, Alexandre de Mendonça,
Depression has been reported to increase the risk of subsequently developing dementia, but the nature of this relation remains to be elucidated. Depression can be a prodrome/manifestation of dementia or an early risk factor, and the effect may differ according to depression subtypes. Our aim was to study the association between early-onset depression and different depression subtypes, and the later occurrence of dementia. We conducted a cohort study including 322 subjects with depression, recruited ...
Tópico(s): Memory and Neural Mechanisms
2016 - Elsevier BV | Journal of Affective Disorders
Isabel Onofre, Nuno Mendonça, Sara Lopes, Rui Jorge Nobre, Joana Barbosa Melo, Isabel M. Carreira, Cristina Januário, António Freire Gonçalves, Luís Pereira de Almeida,
Abstract Machado Joseph Disease (MJD) is the most frequent autosomal dominantly inherited cerebellar ataxia caused by the over-repetition of a CAG trinucleotide in the ATXN3 gene. This expansion translates into a polyglutamine tract within the ataxin-3 protein that confers a toxic gain-of-function to the mutant protein ataxin-3, contributing to protein misfolding and intracellular accumulation of aggregates and neuronal degeneration. Autophagy impairment has been shown to be one of the mechanisms ...
Tópico(s): Mitochondrial Function and Pathology
2016 - Nature Portfolio | Scientific Reports
Paula Proença, Helena M. Teixeira, Maria Cristina de Mendonça, Fernando Castanheira, Estela P. Marques, Francisco Gonçalves, Duarte Nuno Vieira,
The carbamate aldicarb (Temik®) is a highly toxic (LD50 = 0.9 mg/kg oral in rats) insecticide often used in agriculture. The authors present a fatal intoxication case with aldicarb, in a 24-year-old male, under police custody in the island of S. Tome and Prince (STP), in Africa. He was found 3 h after his arrest, lying on the floor of his cell, unconscious, frothing at the mouth, and entered into the hospital already dead. Aldicarb analysis was carried out by high-performance liquid chromatography, with ...
Tópico(s): Animal Ecology and Behavior Studies
2004 - Elsevier BV | Forensic Science International
Nuno Rocha, Patrícia V. Mendonça, Joana R. Góis, Rosemeyre A. Cordeiro, Ana C. Fonseca, Paula Ferreira, Tamaz Guliashvili, Krzysztof Matyjaszewski, Arménio C. Serra, Jorge F. J. Coelho,
Recent developments in controlled/living radical polymerization methods (CLRP) have created the opportunity to prepare polymeric based systems with site specific functionality that has significantly expanded the range of physical and chemical properties that can be generated in materials prepared by these systems. For example, CLRP prepared block copolymers can self-assemble into nanoparticles that can be used in drug delivery applications. The development of synthetic procedures for preparation ...
Tópico(s): Polymer Surface Interaction Studies
2013 - Springer Nature (Netherlands) | Advances in predictive, preventive and personalised medicine
Pedro M. Costa, Ana L. Cardoso, Liliana Mendonça, Angelo Serani, Carlos Custódia, Mariana Conceição, Sérgio Simões, João Nuno Moreira, Luís Pereira de Almeida, Maria C. Pedroso de Lima,
The present work aimed at the development and application of a lipid-based nanocarrier for targeted delivery of nucleic acids to glioblastoma (GBM). For this purpose, chlorotoxin (CTX), a peptide reported to bind selectively to glioma cells while showing no affinity for non-neoplastic cells, was covalently coupled to liposomes encapsulating antisense oligonucleotides (asOs) or small interfering RNAs (siRNAs). The resulting targeted nanoparticles, designated CTX-coupled stable nucleic acid lipid particles ( ...
Tópico(s): MicroRNA in disease regulation
2013 - Cell Press | Molecular Therapy — Nucleic Acids
André Almeida, MARIA L. DELGADO, Sónia Soares, A. Castro, Maria João Moreira, Carla Mendonça, Nuno Canada, José Manuel Correia da Costa, HELENA G. COELHO,
... papers by this authorCARLA M. MENDONÇA, CARLA M. MENDONÇA Centro de Estudo de Ciência Animal, ICETA, Universidade do Porto, and Abel Salazar Institute for Biomedical Sciences, ICBAS, Universidade do Porto, Portugal, andSearch for more papers by this authorNUNO B. CANADA, NUNO B. CANADA Centro de Estudo de Ciência Animal, ... papers by this authorCARLA M. MENDONÇA, CARLA M. MENDONÇA Centro de Estudo de Ciência Animal, ICETA, Universidade do Porto, and Abel Salazar Institute for Biomedical Sciences, ICBAS, Universidade do Porto, Portugal, andSearch for more papers by this authorNUNO B. CANADA, NUNO B. CANADA Centro de Estudo de Ciência Animal, ...
Tópico(s): Viral gastroenteritis research and epidemiology
2006 - Wiley | Journal of Eukaryotic Microbiology
André Almeida, MARIA L. DELGADO, Sónia Soares, A. Castro, Maria João Moreira, Carla Mendonça, Nuno Canada, José Manuel Correia da Costa,
... papers by this authorCARLA M. MENDONÇA, CARLA M. MENDONÇA Centro de Estudo de Ciência Animal—ICETA, Universidade do Porto, Porto, Portugal, and Abel Salazar Institute for Biomedical Sciences—ICBAS, Universidade do Porto, PortugalSearch for more papers by this authorNUNO B. CANADA, NUNO B. CANADA Centro de Estudo de Ciência Animal— ... papers by this authorCARLA M. MENDONÇA, CARLA M. MENDONÇA Centro de Estudo de Ciência Animal—ICETA, Universidade do Porto, Porto, Portugal, and Abel Salazar Institute for Biomedical Sciences—ICBAS, Universidade do Porto, PortugalSearch for more papers by this authorNUNO B. CANADA, NUNO B. CANADA Centro de Estudo de Ciência Animal— ...
Tópico(s): Enterobacteriaceae and Cronobacter Research
2006 - Wiley | Journal of Eukaryotic Microbiology
Carla Mendonça, André Almeida, A. Castro, Maria de Lurdes Delgado, Sónia Soares, José Manuel Correia da Costa, Nuno Canada,
Fecal samples from 291 calves and 176 adult cattle in Northern Portugal were screened for Cryptosporidium and Giardia using a formalin–ethyl acetate concentration method. Acid-fast staining techniques for Cryptosporidium oocyst identification and direct microscopic observation of fecal smears for Giardia cyst identification were performed so as immunofluorescence microscopy examination. Polymerase chain reaction methods were employed to determine the genotype of each isolate. Molecular characterization ...
Tópico(s): Amoebic Infections and Treatments
2007 - Elsevier BV | Veterinary Parasitology
Mariana Conceição, Liliana Mendonça, Clévio Nóbrega, Célia Gomes, Pedro M. Costa, Hirokazu Hirai, João Nuno Moreira, Maria C. Pedroso de Lima, N. Manjunath, Luís Pereira de Almeida,
Others and we showed that RNA interference holds great promise for the treatment of dominantly inherited neurodegenerative disorders such as Machado-Joseph disease (MJD), for which there is no available treatment. However, successful experiments involved intracranial administration of viral vectors and there is a need for a safer and less invasive procedure. In this work, we successfully generated stable nucleic acid lipid particles (SNALPs), incorporating a short peptide derived from rabies virus ...
Tópico(s): RNA Research and Splicing
2015 - Elsevier BV | Biomaterials
Leonor Orge, Carla Caroline Valença de Lima, Carla Machado, Paula Tavares, Paula Mendonça, Paulo Carvalho, João P. N. Silva, Maria de Lurdes Pinto, Estela Bastos, Jorge C. Pereira, Nuno Gonçalves-Anjo, Adelina Gama, Alexandra Esteves, Anabela Alves, A.C. Matos, Fernanda Seixas, Filipe Silva, Isabel Pires, L. Figueira, Madalena Vieira‐Pinto, Roberto Sargo, M.A. Pires,
Transmissible Spongiform Encephalopathies (TSEs) or prion diseases are a fatal group of infectious, inherited and spontaneous neurodegenerative diseases affecting human and animals. They are caused by the conversion of cellular prion protein (PrPC) into a misfolded pathological isoform (PrPSc or prion- proteinaceous infectious particle) that self-propagates by conformational conversion of PrPC. Yet by an unknown mechanism, PrPC can fold into different PrPSc conformers that may result in different prion ...
Tópico(s): Trace Elements in Health
2021 - Multidisciplinary Digital Publishing Institute | Biomolecules
Jan‐Thorsten Gräsner, Rolf Lefering, Rudolph W. Koster, Siobhán Masterson, Bernd W. Böttiger, Johan Herlitz, Jan Wnent, Ingvild Tjelmeland, Fernando Rosell Ortiz, H. Mäurer, Michael Baubin, Pierre Mols, Irzal HadžibegoviL·, Marios Ioannides, Roman Škulec, Mads Wissenberg, Ari Salo, Hervé Hubert, Νικόλαος Νικολάου, Gerda Lóczi, Hildigunnur Svavarsdóttir, Federico Semeraro, P.J. Wright, Carlo Clarens, Ruud Pijls, Grzegorz Cebula, Vitor Gouveia Correia, Diana Cimpoeşu, Violetta Raffay, Stefan Trenkler, Andrej Markota, Anneli Strömsöe, Roman Burkart, Gavin D. Perkins, Leo Bossaert, Marc Kaufmann, Markus Thaler, Martin Maier, Gerhard Prause, Helmut Trimmel, Diane de Longueville, Thierry Préseau, Dominique Biarent, Christian Mélot, Nicolas Mpotos, Koenraad G. Monsieurs, Patrick Van de Voorde, Marie Vanhove, Pascale Lievens, Mathias Faniel, Slobodanka Keleuva, Milan Lazarević, Radmila Majhen Ujević, Mato Devcic, Branka Bardak, Fabijan Barisic, Silvija Hunyadi Antičević, Μάριος Γεωργίου, Anatolij Truhlás, Jisí Knor, Eva Smržová, Roman Sviták, Robin Šín, Petr Mokrejš, Freddy Lippert, Juhana Hallikainen, Marko Hoikka, Timo Iirola, Timo Jama, Helena Jäntti, Raimo Jokisalo, Milla Jousi, Hetti Kirves, Markku Kuisma, Jukka Laine, Sami Länkimäki, Petri Loikas, Vesa Lund, Teuvo Määttä, Heini Nal, Heimo M. Niemela, Petra Portaankorva, Marko Pylkkänen, Marko Sainio, Piritta Setälä, Jerry Tervo, Taneli Väyrynen, Timo Jama, Davy Murgue, A. Champenois, Marc Fournier, Daniel Meyrán, Romain Tabary, Aurélie Avondo, Gelin Gelin, Bruno Simonnet, M Joly, Isabelle Megy-Michoux, Xavier Paringaux, Yves Duffait, Michael Vial, Julien Segard, Sophie Narcisse, David Hamban, Jonathan Hennache, Sylvain Thiriez, Mathieu Doukhan, Carine Vanderstraeten, Jean-Charles Morel, Gilles Majour, Corinne Michenet, Laurent Tritsch, Marc Dubesset, Olivier Peguet, David Piñero, F Guillaumée, Patrick Fuster, Jean-François Ciacala, B. Jardel, Jean-Yves Letarnec, Frank Goes, Philippe Gosset, Muriel Vergne, Christian Bär, Fabienne Branche, Stevens Prineau, Steven Lagadec, Carole Cornaglia, C. Ursat, P Bertrand, Jean‐Marc Agostinucci, Pierre Nadiras, Géraldine Gonzales de Linares, Line Jacob, François Revaux, Thomas Pernot, Nathalie Roudiak, A. Ricard-Hibon, Laurent Villain-Coquet, Stefan Beckers, Thomas C. Hanff, Bernd Strickmann, Nicolai Wiegand, P. Wilke, Harald Sues, S. Bogatzki, Wolfgang Baumeier, Kai Pohl, B Werner, Hans Fischer, Torsten Zeng, Erik Popp, Andreas Guenther, Andreas Hochberg, A. Lechleuthner, Jens‐Christian Schewe, Hans Lemke, Erich Wranze-Bielefeld, Andreas Böhn, Markus Roeßler, Frank Naujoks, Frank Sensen, Torben Esser, Matthias Fischer, Martin Messelken, Christopher Rose, G. Schlüter, W. Lotz, Michael Corzilius, Claus-Martin Muth, Christian Diepenseifen, Björn Tauchmann, Torsten Birkholz, A. Flemming, Stefanie Herrmann, U. Kreimeier, Clemens Kill, Frank Marx, R Schröder, W. Lenz, Glykeria Botini, Barakos Grigorios, N. Giannakoudakis, Michail Zervopoulos, Dimitrios Papangelis, Sofia Petropoulou-Papanastasiou, Themistoklis Liaskos, Spyridon Papanikolaou, Andreas Karabinis, Attila Zentay, Hólmgeir ÿorsteinsson, Anna Gilsdóttir, S Birgisson, Fjölnir Freyr Guðmundsson, Hallgrímur Hreiðarsson, Björgvin ÿrnason, Hermann Hermannsson, Gísli Björnsson, Brynjar ÿór Friðriksson, Gunnar Baldursson, ÿrmann Höskuldsson, Jórunn Valgarðsdottir, Matthildur ÿsmundardóttir, Guðmundur A. Guðmundsson, Hjörtur Kristjánsson, Eyþór Rúnar ÿórarinsson, Jon Oskar Gudlaugsson, Sigurður Skarphéðinsson, Alberto Peratoner, Andrea Santarelli, Cesare Sabetta, Giovanni Gordini, Giovanni Sesana, Riccardo Giudici, Simone Savastano, Tommaso Pellis, Jean Beissel, Jean Uhrig, Tom Manderscheid, Marco Klop, Pascal Stammet, Marc Koch, Philippe Welter, R Schuman, Wendy Bruins, Hesam Amin, Nina Braa, Staale Bratland, Eirik Alnes Buanes, Tomas Drægni, Knut Roar Johnsen, Wenche Torunn Mathisen, Terje Oedegaarden, Marie Oppedal, Alf Stolt-Nielsen Reksten, Mats Eirik Roedsand, Jon Erik Steen-Hansen, Marta Dyrda, Anna Frejlich, Ssawomir MaciL·g, Sonia Osadnik, Ireneusz Weryk, Eugénio Mendonça, Carlos Clayton Macedo de Freitas, Pinto Cruz, Carmo Caldeira, José Barros, Luís Vale, António Brazão, Nuno Jardim, Fernanda Rocha, Ricardo Duarte, Nicodemos Fernandes, Pedro Ramos, Margarida Jardim, Miguel Reis, Rômulo José da Costa Ribeiro, Sérgio Zenha, Jorge Fernandes, Juan Francisco, David N. Assis, Fernanda Abreu, Dinarte Freitas, Leonardo Coutinho Ribeiro, Paulo Henrique Silva Marques de Azevedo, Débora Calafatinho, Rui Jardim, Aleixo Pestana, Rui Faria, Bogdan Oprita, Alis Grasu, Paul Nedelea, Sorina Sovar, Florin Agapi, Aleksandar KliL·koviL·, Aleksandra LaziL·, Bogdan NikoliL·, Bogdan Zivanovic, Branislav MartinoviL·, Dušan MilenkoviL·, HuseinoviL· Damir, Jovanka Koprivica, Kornelija Horvat JakšiL·, Margit Pajor, Saša MiliL·, Mirko VidoviL·, Radojka Petrovic Glamoclija, Sladjana Andjelić, Vlajovic Sladjana, Zlatko BabiL·, Z Fiser, Peter Androvic, Ľubica Bajerovská, Miroslav Chabroň, Viliam Dobias, Eva Havlíková,
The aim of the EuReCa ONE study was to determine the incidence, process, and outcome for out of hospital cardiac arrest (OHCA) throughout Europe.This was an international, prospective, multi-centre one-month study. Patients who suffered an OHCA during October 2014 who were attended and/or treated by an Emergency Medical Service (EMS) were eligible for inclusion in the study. Data were extracted from national, regional or local registries.Data on 10,682 confirmed OHCAs from 248 regions in 27 countries, ...
Elsevier BV
J Monteiro, R. Rodrigues, Micaela Neto, J Sousa, Flávio Mendonça, M Serrão, Nuno Santos, Bruno M. Silva, Ana Paula de Faria, Décio Pereira, E Henriques, António Drumond Freitas, M I Mendonça,
Complex risk scores have limited applicability in the assessment of patients with myocardial infarction (MI). In this work, the authors aimed to develop a simple to use clinical score to stratify the in-hospital mortality risk of patients with MI at first medical contact. In this single-center prospective registry assessing 1504 consecutively admitted patients with MI, the strongest predictors of in-hospital mortality were selected through multivariate logistic regression. The KAsH score was developed ...
Tópico(s): Healthcare cost, quality, practices
2019 - Elsevier BV | Revista Portuguesa de Cardiologia
Mariana Conceição, Liliana Mendonça, Clévio Nóbrega, Célia Gomes, Pedro M. Costa, Hirokazu Hirai, João Nuno Moreira, Maria C. Pedroso de Lima, N. Manjunath, Luís Pereira de Almeida,
In a clinical setting, where multiple administrations of the therapeutic agent are usually required to improve the therapeutic outcome, it is crucial to assess the immunogenicity of the administered nanoparticles. In this data work, we investigated the safety profile of the repeated intravenous administration of brain-targeted stable nucleic acid lipid particles (RVG-9r-targeted SNALPs). To evaluate local activation of the immune system, we performed analysis of mouse tissue homogenates and sections ...
Tópico(s): Toxoplasma gondii Research Studies
2016 - Elsevier BV | Data in Brief
Gaëlle Marteil, Adán Guerrero, André Filipe Vieira, Bernardo P. de Almeida, Pedro Machado, Susana Mendonça, Marta Mesquita, Beth Villarreal, Irina Fonseca, María E. Francia, Katharina Dores, Nuno Pimpão Martins, Swadhin Chandra Jana, Erin M. Tranfield, Nuno L. Barbosa‐Morais, Joana Paredes, David Pellman, Susana A. Godinho, Mónica Bettencourt‐Dias,
Abstract Centrosomes are the major microtubule organising centres of animal cells. Deregulation in their number occurs in cancer and was shown to trigger tumorigenesis in mice. However, the incidence, consequence and origins of this abnormality are poorly understood. Here, we screened the NCI-60 panel of human cancer cell lines to systematically analyse centriole number and structure. Our screen shows that centriole amplification is widespread in cancer cell lines and highly prevalent in aggressive ...
Tópico(s): Cancer-related Molecular Pathways
2018 - Nature Portfolio | Nature Communications