Keiichi Yonemori, Naohiko Seki, Tetsuya Idichi, Hiroshi Kurahara, Yusaku Osako, Keiichi Koshizuka, Takayuki Arai, Atsushi Okato, Yoshiaki Kita, Takaaki Arigami, Yuko Mataki, Yuko Kijima, Kosei Maemura, Shoji Natsugoe,
... 1 , Keiichi Koshizuka 2 , Takayuki Arai 2 , Atsushi Okato 2 , Yoshiaki Kita 1 , Takaaki Arigami 1 , Yuko ...
Tópico(s): RNA modifications and cancer
2017 - Impact Journals LLC | Oncotarget
Tetsuya Idichi, Naohiko Seki, Hiroshi Kurahara, Keiichi Yonemori, Yusaku Osako, Takayuki Arai, Atsushi Okato, Yoshiaki Kita, Takaaki Arigami, Yuko Mataki, Yuko Kijima, Kosei Maemura, Shoji Natsugoe,
... 1 , Yusaku Osako 1 , Takayuki Arai 2 , Atsushi Okato 2 , Yoshiaki Kita 1 , Takaaki Arigami 1 , Yuko ...
Tópico(s): RNA modifications and cancer
2017 - Impact Journals LLC | Oncotarget
Keiichi Koshizuka, Naoko Kikkawa, Toyoyuki Hanazawa, Yasutaka Yamada, Atsushi Okato, Takayuki Arai, Koji Katada, Yoshitaka Okamoto, Naohiko Seki,
... 2 , Toyoyuki Hanazawa 2 , Yasutaka Yamada 1 , Atsushi Okato 1 , Takayuki Arai 1 , Koji Katada 2 , Yoshitaka ...
Tópico(s): Circular RNAs in diseases
2017 - Impact Journals LLC | Oncotarget
Koichiro Osozawa, Nobuyoshi Okato, Yasushi Fukase, K. Yokota,
Effects of alloying elements on the pitting corrosion resistance of 17Cr-16Ni steels with and without 4% Mo were evaluated by the corrosion rate in 10% FeCl3·6H2O and 4% NaCl added with hydrogen peroxide and by the polarization measurement in 0.1N NaCl+0.1-0.25N Na2SO4 at 40°C. The elements, the content of which was varied, were carbon, nitrogen, silicon, phosphorus, sulfur, manganese and nickel. The supplementary alloying elements were aluminum, titanium, vanadium, cobalt, copper, zirconium, niobium, ...
Tópico(s): Microstructure and Mechanical Properties of Steels
1975 - | Corrosion engineering digest
... 220 yr b.p. At most localities the Okato Tephra, dated (NZ1143 at 12 550 ± 150 yr ...
Tópico(s): Coastal wetland ecosystem dynamics
1975 - Taylor & Francis | New Zealand Journal of Geology and Geophysics
Akira Ninomiya, Toshitaka Okato,
(1990). A Critical Analysis of Job‐satisfied Teachers in Japan. Comparative Education: Vol. 26, No. 2-3, pp. 249-257.
Tópico(s): Global Education and Multiculturalism
1990 - Taylor & Francis | Comparative Education
Shuichiro Okato, Sumiko Magari, Yūzō Yamamoto, Masahiro Sakanaka, Hiroaki Takahashi,
The sites of interaction between antigenpresenting cells (dendritic cells, macrophages) and lymphocytes in the human palatine tonsil were investigated by pre-embedding immuno-electron microscopy and acid-phosphatase histochemistry. Used in this study were: an S-100 protein antiserum recognizing Langerhans cells and interdigitating cells, OKT6 monoclonal antibody reacting with surface antigens of Langerhans cells, and Leu-3a monoclonal antibody directed to surface antigens of helper-T-cells.In the ...
Tópico(s): Antimicrobial Peptides and Activities
1989 - International Society Histology & Cytology | Archives of Histology and Cytology
Yūzō Yamamoto, Shuichiro Okato, Hiroaki Takahashi, Kazuo Takeda, Sumiko Magari,
The distribution and morphology of macrophages were studied by immunohistochemical and electronmicroscopic methods in three diseases of the palatine tonsils: tonsillar hypertrophy, recurrent tonsillitis and tonsils with focal infection. We confirmed the presence of two types of macrophages in the tonsils, a monocyte-macrophage cell line and dendritic cells with subtypes, Langerhans' and interdigitating reticulum cells. In the lymphoepithelial symbiosis area and in the subepithelial area, the monocyte- ...
Tópico(s): Streptococcal Infections and Treatments
1988 - Taylor & Francis | Acta Oto-Laryngologica
Solis Norton, C. Heuer, Rod Jackson,
... Clinic, Manawatu Veterinary Services, Morrinsville Animal Health Centre, Okato Veterinary Clinic, New Plymouth-Stratford District Vet Services, ...
Tópico(s): Infectious Diseases and Mycology
2009 - Taylor & Francis | New Zealand Veterinary Journal
Ryo Nishimura, Tatsunori Sakano, Takeshi Okato, Toshiharu Saiki, Minoru Obara,
We demonstrate the growth of ZnO nanorods on a Si(100) substrate through a two-step process, annealing and off-axis pulsed laser deposition (PLD), without a catalyst. ZnO powder was first dispersed on the Si substrate, and annealed to form seeds for ZnO nanorod growth for 2.5 h. In the second step, ZnO was deposited on the seeds by PLD for 1 h. It was experimentally confirmed that the surface morphology after annealing acts as growth nuclei of nanorods. Controlling growth parameters during deposition ...
Tópico(s): Gas Sensing Nanomaterials and Sensors
2008 - Institute of Physics | Japanese Journal of Applied Physics
Takeshi Okato, Tatsunori Sakano, Minoru Obara,
We report the role of N in epitaxial films of anatase $\mathrm{Ti}{\mathrm{O}}_{2}$. The films were artificially grown with a two-step temperature-tuned epitaxy which utilized the high-temperature cubic phase of $\mathrm{La}\mathrm{Al}{\mathrm{O}}_{3}$ substrates. The preparation of highly crystallized anatase with various N concentrations $({C}_{\mathrm{N}}\ensuremath{\leqslant}3.85\phantom{\rule{0.3em}{0ex}}\mathrm{at.}\phantom{\rule{0.2em}{0ex}}%)$ allowed us to identify the optimum dopant concentration $({ ...
Tópico(s): TiO2 Photocatalysis and Solar Cells
2005 - American Physical Society | Physical Review B
Akira Kurozumi, Yusuke Goto, Atsushi Okato, Tomohiko Ichikawa, Naohiko Seki,
Tópico(s): Circular RNAs in diseases
2016 - Springer Nature | Journal of Human Genetics
Ichiro Fukumoto, Keiichi Koshizuka, Toyoyuki Hanazawa, Naoko Kikkawa, Ryosuke Matsushita, Akira Kurozumi, Mayuko Kato, Atsushi Okato, Yoshitaka Okamoto, Naohiko Seki,
Our recent studies of microRNA (miRNA) expression signatures in human cancers revealed that two clustered miRNAs, microRNA-23b (miR-23b) and microRNA-27b (miR‑27b), were significantly reduced in cancer tissues. Few reports have provided functional analyses of these clustered miRNAs in oral squamous cell carcinoma (OSCC). The aim of this study was to investigate the functional significance of miR-23b and miR-27b in OSCC and to identify novel miR-23b/27b-mediated cancer pathways and target genes involved ...
Tópico(s): RNA modifications and cancer
2016 - Spandidos Publishing | International Journal of Oncology
Atsushi Okato, Yusuke Goto, Akira Kurozumi, Mayuko Kato, Satoko Kojima, Ryosuke Matsushita, Masaya Yonemori, Kazutaka Miyamoto, Tomohiko Ichikawa, Naohiko Seki,
Advanced prostate cancer (PCa) metastasizes to bone and lymph nodes, and currently available treatments cannot prevent the progression and metastasis of the disease. Therefore, an improved understanding of the molecular mechanisms of the progression and metastasis of advanced PCa using current genomic approaches is needed. Our miRNA expression signature in castration-resistant prostate cancer (CRPC) revealed that microRNA-320a (miR‑320a) was significantly reduced in cancer tissues, suggesting that ...
Tópico(s): Extracellular vesicles in disease
2016 - Spandidos Publishing | International Journal of Oncology
Mayuko Kato, Akira Kurozumi, Yusuke Goto, Ryosuke Matsushita, Atsushi Okato, Rika Nishikawa, Ichiro Fukumoto, Keiichi Koshizuka, Tomohiko Ichikawa, Naohiko Seki,
Tópico(s): Inflammatory mediators and NSAID effects
2016 - Springer Nature | Journal of Human Genetics
Yusuke Goto, Satoko Kojima, Akira Kurozumi, Mayuko Kato, Atsushi Okato, Ryosuke Matsushita, Tomohiko Ichikawa, Naohiko Seki,
MicroRNA-224 (miR-224) and microRNA-452 (miR-452) are closely located on the human chromosome Xq28 region. miR-224 functions as a tumour suppressor by targeting tumour protein D52 (TPD52) in prostate cancer (PCa). Here, we aimed to investigate the functional significance of miR-452 in PCa cells.Functional studies of PCa cells were performed using transfection with mature miRNAs or siRNAs. Genome-wide gene expression analysis, in silico analysis, and dual-luciferase reporter assays were applied to identify ...
Tópico(s): Cancer-related molecular mechanisms research
2016 - Springer Nature | British Journal of Cancer
Akira Kurozumi, Mayuko Kato, Yusuke Goto, Ryosuke Matsushita, Rika Nishikawa, Atsushi Okato, Ichiro Fukumoto, Tomohiko Ichikawa, Naohiko Seki,
Our recent studies of microRNA (miRNA) expression signatures in human cancers revealed that microRNA-26a (miRNA-26a) and microRNA-26b (miRNA-26b) were significantly reduced in cancer tissues. To date, few reports have provided functional analyses of miR-26a or miR-26b in renal cell carcinoma (RCC). The aim of the present study was to investigate the functional significance of miR-26a and miR-26b in RCC and to identify novel miR-26a/b-mediated cancer pathways and target genes involved in RCC oncogenesis ...
Tópico(s): Angiogenesis and VEGF in Cancer
2016 - Spandidos Publishing | International Journal of Oncology
Yusaku Osako, Naohiko Seki, Keiichi Koshizuka, Atsushi Okato, Tetsuya Idichi, Takayuki Arai, Itaru Omoto, Ken Sasaki, Yasuto Uchikado, Yoshiaki Kita, Hiroshi Kurahara, Kosei Maemura, Shoji Natsugoe,
Tópico(s): RNA modifications and cancer
2017 - Springer Nature | Journal of Human Genetics
Yusuke Goto, Akira Kurozumi, Takayuki Arai, Nijiro Nohata, Satoko Kojima, Atsushi Okato, Mayuko Kato, Kazuto Yamazaki, Yasuo Ishida, Yukio Naya, Tomohiko Ichikawa, Naohiko Seki,
Despite recent advancements, metastatic castration-resistant prostate cancer (CRPC) is not considered curative. Novel approaches for identification of therapeutic targets of CRPC are needed. Next-generation sequencing revealed 945–1248 miRNAs from each lethal mCRPC sample. We constructed miRNA expression signatures of CRPC by comparing the expression of miRNAs between CRPC and normal prostate tissue or hormone-sensitive prostate cancer (HSPC). Genome-wide gene expression studies and in silico analyses ...
Tópico(s): MicroRNA in disease regulation
2017 - Springer Nature | British Journal of Cancer
Yasutaka Yamada, Rika Nishikawa, Mayuko Kato, Atsushi Okato, Takayuki Arai, Satoko Kojima, Kazuto Yamazaki, Yukio Naya, Tomohiko Ichikawa, Naohiko Seki,
Tópico(s): Circular RNAs in diseases
2017 - Springer Nature | Journal of Human Genetics
Keiichi Koshizuka, Toyoyuki Hanazawa, Naoko Kikkawa, Koji Katada, Atsushi Okato, Takayuki Arai, Tetsuya Idichi, Yusaku Osako, Yoshitaka Okamoto, Naohiko Seki,
Objective Our recent studies have revealed that both strands of pre-miRNAs, the guide strand and the passenger strand, are involved in cancer pathogenesis. Analyses of miRNA expression signatures by RNA sequencing in head and neck squamous cell carcinoma (HNSCC) showed that both of the strands of pre-miR-150 (miR-150-5p and miR-150-3p) were significantly downregulated, and that these miRNAs acted as antitumor miRNAs in HNSCC cells. The aim of this study was to identify oncogenic genes in HNSCC cells ...
Tópico(s): RNA modifications and cancer
2017 - Elsevier BV | Auris Nasus Larynx
Keiichi Koshizuka, Toyoyuki Hanazawa, Takayuki Arai, Atsushi Okato, Naoko Kikkawa, Naohiko Seki,
Tópico(s): RNA modifications and cancer
2017 - Springer Science+Business Media | Cancer and Metastasis Reviews
Takayuki Suetsugu, Keiichi Koshizuka, Naohiko Seki, Keiko Mizuno, Atsushi Okato, Takayuki Arai, Shunsuke Misono, Akifumi Uchida, Tomohiro Kumamoto, Hiromasa Inoue,
In the present study, in order to elucidate the aggressive nature of lung squamous cell carcinoma (LUSQ), we investigated the oncogenic RNA networks regulated by antitumor microRNAs (miRNAs or miRs) in LUSQ cells. The analysis of our original miRNA expression signatures of human cancers revealed that microRNA‑150‑5p (miR‑150‑5p) was downregulated in various types of cancer, indicating that miR‑150‑5p acts as an antitumor miRNA by targeting several oncogenic genes. Thus, the aims of this study were ...
Tópico(s): RNA modifications and cancer
2017 - Spandidos Publishing | International Journal of Oncology
Keiichi Koshizuka, Nijiro Nohata, Toyoyuki Hanazawa, Naoko Kikkawa, Takayuki Arai, Atsushi Okato, Ichiro Fukumoto, Koji Katada, Yoshitaka Okamoto, Naohiko Seki,
We adopted into RNA-sequencing technologies to construct the microRNA (miRNA) expression signature of head and neck squamous cell carcinoma (HNSCC). Our signature revealed that a total of 160 miRNAs (44 upregulated and 116 downregulated) were aberrantly expressed in cancer tissues. Expression of miR-150-5p (guide strand miRNA) and miR-150-3p (passenger strand miRNA) were significantly silenced in cancer tissues, suggesting both miRNAs act as antitumor miRNAs in HNSCC cells. Ectopic expression of mature ...
Tópico(s): Circular RNAs in diseases
2017 - Impact Journals LLC | Oncotarget
Takayuki Arai, Atsushi Okato, Satoko Kojima, Tetsuya Idichi, Keiichi Koshizuka, Akira Kurozumi, Mayuko Kato, Kazuto Yamazaki, Yasuo Ishida, Yukio Naya, Tomohiko Ichikawa, Naohiko Seki,
Analysis of our original micro RNA (mi RNA ) expression signature of patients with advanced renal cell carcinoma ( RCC ) showed that micro RNA ‐10a‐5p ( miR‐10a‐5p ) was significantly downregulated in RCC specimens. The aims of the present study were to investigate the antitumor roles of miR‐10a‐5p and the novel cancer networks regulated by this mi RNA in RCC cells. Downregulation of miR‐10a‐5p was confirmed in RCC tissues and RCC tissues from patients treated with tyrosine kinase inhibitors ( TKI ). Ectopic expression ...
Tópico(s): Epigenetics and DNA Methylation
2017 - Wiley | Cancer Science
Keiichi Koshizuka, Toyoyuki Hanazawa, Naoko Kikkawa, Takayuki Arai, Atsushi Okato, Akira Kurozumi, Mayuko Kato, Koji Katada, Yoshitaka Okamoto, Naohiko Seki,
For patients with head and neck squamous cell carcinoma ( HNSCC ), survival rates have not improved due to local recurrence and distant metastasis. Current targeted molecular therapies do not substantially benefit HNSCC patients. Therefore, it is necessary to use advanced genomic approaches to elucidate the molecular mechanisms underlying the aggressiveness of HNSCC cells. Analysis of our micro RNA (mi RNA ) expression signature by RNA sequencing showed that the miR‐199 family ( miR‐199a‐5p , miR‐199a‐3p , miR‐ ...
Tópico(s): MicroRNA in disease regulation
2017 - Wiley | Cancer Science
Yasutaka Yamada, Keiichi Koshizuka, Toyoyuki Hanazawa, Naoko Kikkawa, Atsushi Okato, Tetsuya Idichi, Takayuki Arai, Sho Sugawara, Koji Katada, Yoshitaka Okamoto, Naohiko Seki,
Analysis of the microRNA (miRNA) expression signature of head and neck squamous cell carcinoma (HNSCC) based on RNA sequencing showed that dual strands of pre‑miR‑145 (miR‑145‑5p, guide strand; and miR‑145‑3p, passenger strand) were significantly reduced in cancer tissues. In miRNA biogenesis, passenger strands of miRNAs are degraded and have no biological activities in cells. The aims of this study were to investigate the functional significance of the passenger strand of miR‑145 and to identify miR‑ ...
Tópico(s): RNA modifications and cancer
2017 - Spandidos Publishing | International Journal of Oncology
Atsushi Okato, Takayuki Arai, Satoko Kojima, Keiichi Koshizuka, Yusaku Osako, Tetsuya Idichi, Akira Kurozumi, Yusuke Goto, Mayuko Kato, Yukio Naya, Tomohiko Ichikawa, Naohiko Seki,
Analysis of our microRNA (miRNA) expression signature in human cancers has shown that guide and passenger strands of pre-miR‑150, i.e., miR‑150‑5p and miR‑150‑3p, are significantly downregulated in cancer tissues. In miRNA biogenesis, the passenger strand of miRNA is degraded and is thought to have no functions. Thus, the aim of this study was to investigate the functional significance of miR‑150‑5p and miR‑150‑3p in naïve prostate cancer (PCa) and castration-resistant prostate cancer (CRPC). Ectopic ...
Tópico(s): RNA modifications and cancer
2017 - Spandidos Publishing | International Journal of Oncology
Keiko Mizuno, Hiroko Mataki, Takayuki Arai, Atsushi Okato, Kazuto Kamikawaji, Tomohiro Kumamoto, Tsubasa Hiraki, Kazuhito Hatanaka, Hiromasa Inoue, Naohiko Seki,
Tópico(s): Cancer Mechanisms and Therapy
2017 - Springer Nature | Journal of Human Genetics
Atsushi Okato, Takayuki Arai, Yasutaka Yamada, Sho Sugawara, Keiichi Koshizuka, Lisa Fujimura, Akira Kurozumi, Mayuko Kato, Satoko Kojima, Yukio Naya, Tomohiko Ichikawa, Naohiko Seki,
Our recent studies revealed that dual strands of certain pre-microRNAs, e.g., pre-miR-144, pre-miR-145, and pre-miR-150, act as antitumor microRNAs (miRNAs) in several cancers. The involvement of passenger strands of miRNAs in cancer pathogenesis is a novel concept in miRNA research. The analysis of a miRNA expression signature in clear cell renal cell carcinoma (ccRCC) has revealed that the guide strand of pre-miR-149 is significantly downregulated in cancer tissues. The aims of this study were to ...
Tópico(s): FOXO transcription factor regulation
2017 - Multidisciplinary Digital Publishing Institute | International Journal of Molecular Sciences