Sally Brock, V S, Professor Gideon Garter, Ashia Hansen, Ferdinand Mount, Polly Poynbee, David Hopkins, Neil Wormald, Fiona Ronaldson, Kingstom Smith, Roger Panding, Joseph Dunn, Martin James, Anthony Sattin, Rosie Millard, Phil Baty, David Hewson, Hugh Canning, Sarah Dempster, Kevin Jackson, Peter Millar, Ashley Stoop, Mark Fitzsimons, Tom Tom, Catherine Lunken, John Humphrys, Nicholas Hellen, Danny Scott, Alicia Wyllie, Jim McGill, Paul Martin, Chemmy Alcott, Ed Porter, Adrain Furnham, Nick Rennison, T Tarlton, Bob Dwuer, Bryan Appleyard, John Elliott, Ali Allen, Maurice Chittenden, Richard Brooks Arts Editor, Brian Smyth, Godfrey Smith, Alex Pell, Matthew Campbell, Louise Johncox, Enda Leahy, Jacqui Goddard, Graham Norwood, David Budworth, William Lewis Business editor, Jane Horrocks, Mrs Mills, Susannah Price, Sarah Baxter, David McLeish, Bob Dwyer, Ed Hughes, Pamela Coleman, Jason Dawe, William Gray, Jonathan Northcroft, Hala Jaber, Matthew Wall, Colin Coyle, Felice Hardy, Peter Whittle, Andrew Longmore, Melanie Eskenazi, Caroline Brannigan, Paul Marinko, Steven Poole, E P, Andrew Sullivan, Clive Davis, Doug Bradshaw, Alan Milburn, Colin Batsman, Tom Otley, Christobel Flood, Fiona MacDonald-Smith, Anna Bruning, Peter Jones, David Bond, Carole Tucker, Frank Dobson, Alasdair Reid, D Taylor, Gilly Banyard, Victoria Segal, Edward Porter, Dave Pollard, Rosy Cheeks, Patrick Maxwell, Shelley von Strunckel, Geoffrey Wheatcroft, Doug Sager, Christopher Silvester, Stuart Wavell, Paul Donovan, David Howgrave-Graham, Steve Boyd, Garth Pearce, Richard Brooks, Stuart Andrews, David Leppard, Sarah Rundell, Graham Bell, Scott Atkins, Alan Combes, Gareth Huw Davies, David Cracknell, Jayesh Ghaghda, Katrina Manson, Greg Hadfield, Diana Wright, Clare Short, Barry Flatman, Kenneth Clarke, Natalie Graham, David Walsh, Jack Grimston, Andreas Viestad, Stephen Armstrong, Bethan Cole, Michael Sheridan Far East Correspondent, N R, Richard Woods, Martin Pilcher, Ray Hutton, Chris woodhead, Ian Thomson, A A Gill, Lord Fowler, Michael Bright, Brian Doogan, Ben Dowell, Clifford Bishop, John Cornwell, Jonathan Futrell, Victor Bryant, Hugh Pearman, Tom Deveson, Martin Booth, Ann Waite, Richard Lewis, Helen Stewart, John Dugdale, Barbara Hall, Nigel Botherway, Nicholas Rufford, Stuart Shaw, Rob Hughes, John Peter, Susan d'Arcy, Ivo Tennant, Markie Robson-Scott, David Smith, Tim Richards, David Cracknell Political Editor, Dipesh Gadher Transport Correspondent, Tom English, Alastair Campbell, Lawrence Dallaglio, Susanna Doyle, John McCarthy, Sir Brian Barder, Stewart Lee, Peter Conradi, Debbie Taylor, Helen Kenny, Patricia Nicol, John O'Donnell, Brain Deogan, Jeremy Guscott, Christine Toomey, Vincent Crump, Chris Woodhead, Harvey Cole, Alex Clark, Mark Edwards, Rachel Bridge, Susan Clark, Rajiv Radhakrishnan Pinner, Stuart Miles, Chloë Beeney, Sean Newsom, Boris Becker, Lizzie McGuire, Raymond Keene, Peter Howarth, Stephen Jones, Paul Sullivan, Louise Armitstead, Nick Cain, Melinda Stevens, Tim Moorey, Gary Buchanan, Trevor Lewis, Victoria O'brien, Roland White, Peter Hardy, Alex Fortune, Stuart Derrick, Richard Rae, Mark Franchetti, Jon Ungoed-Thomas, Susan Elkin, Michael Sheridan, Barry Collins, John Waples, Hunter Davies, Jeremy Hart, Ralph Oswick, Roger Holmes, Stephen Pettitt, Maria McErlane, Mark Hodson, Andrew Frankel, George, Joe Lovejoy, Dan Cairns, David Grylls, David Smith Economics Editor, Simon Howard, Reginald Williams, Dominic Rushe, David Newbury, Fred Redwood, Helen Davies, Daniel Carpenter, Pam Barrett, Barry Toomey, Frank Whitford, Kathryn Cooper, William Lewis, P D, John Simpson, Humphrey Carpenter, Andrew Porter, Tony Allen-Mills, Simon Wilde, Robert Sandall, Rosie Garthwaite, John R Bradley, Robert Winnett, Irwin Stelzer, Brian Glanvilla, Peter Wilson, David Dougill, Rachel Dobson, David Coulthard, Geraldine Hackett Education Correspondent, Jeremy Clarkson, David Cairns, Lydia Slater, Phil Craigie, Paula Robinson, Dame Marie Stubbs, Paul Ham, Roger Eglin, Lucinda Kemeny, Jasper Gerard, Paul Driver, Ian Hawkey, Oleg Gordievsky, Paul Durman, Phill Baker, Lisa Grainger, Gerald Hartup, Arnie Wilson, Lyn Plumpton, Frank Morpeth, Sharron Davies, Christina Lamb, Gillian Anderson, Douglas Alexander, Cosmo Landesman, Dominic O'Connell, Erica Jong, Niall Toner, Caroline Donald, Alan Beale, Colin McDowell, Aleks Sierz, Ron Clarke, Christopher Goodwin, David Lepard, Shane Watson, Judith O'Reilly, Jonathan Leake, Amanda Craig, Clare Francis, Jonathan Leake Science Editor, Sally Kinnes, Naomi Caine, David Wickers, Peter Almond, Minette Marrin, Andrew Davidson, Paul Stephen Lubicz, Zara Phillips, John Alzlewood, Catriona Cook, Joanna Simon, David Robertson, Matthew Goodman, Alistair Cook,
... the Leeds job? Ljungberg's lucky derby winner Iversen rescues tenacious Wolves Okocha deserves better than this ...
2003 - Gale Group | Sunday Times HA GDA
Vegard Iversen, Odd-Helge Fjeldstad, Godfrey Bahiigwa, Frank Ellis, Robert C. James,
This article examines the growing role and impacts of private tax collection under fiscal decentralisation in Uganda. Based on evidence from six rural councils, three aspects of privatised tax collection are examined: (i) the impact on the nature of fiscal corruption; (ii) the problem of overzealous collection; and (iii) the challenge of assessing revenue potentials. While possibly meeting short-term demands for local revenue growth and stability, the present form of private tax collection appears ...
Tópico(s): Taxation and Compliance Studies
2006 - Wiley | Public Administration and Development
Sissel Gyrid Freim Wahl, Hong Dai, Elisabeth Fritzke Emdal, Thomas Berg, Tarje Onsøien Halvorsen, Anine Larsen Ottestad, Marius Lund‐Iversen, Odd Terje Brustugun, Dagny Førde, Erna‐Elise Paulsen, Tom Dønnem, Sigve Andersen, Bjørn Henning Grønberg, Elin Richardsen,
due to emerging therapeutics targeting
Tópico(s): PI3K/AKT/mTOR signaling in cancer
2021 - Multidisciplinary Digital Publishing Institute | Cancers
Lilly Roth, Verena Jordan, Stefania Schwarz, Klaus Willmes, Hans‐Christoph Nuerk, Jean‐Philippe van Dijck, Krzysztof Cipora,
... sided responses to odd/even numbers, respectively; Nuerk, Iversen, & Willmes, 2004), and Odd (i.e., faster responses to even numbers; Hines, ...
Tópico(s): Behavioral and Psychological Studies
2024 - Elsevier BV | Cognition
Jon Michael Gran, Bjørn G Iversen, Olav Hungnes, Odd O. Aalen,
SUMMARY Influenza can be a serious, sometimes deadly, disease, especially for people in high-risk groups such as the elderly and patients with underlying, severe disease. In this paper we estimated the influenza-related excess mortality in Norway for 1975–2004, comparing it with dominant virus types and estimates of the reproduction number. Analysis was done using Poisson regression, explaining the weekly all-cause mortality by rates of reported influenza-like illness, together with markers for ...
Tópico(s): Viral Infections and Vectors
2010 - Cambridge University Press | Epidemiology and Infection
Ane Kongsgaard, Marius Lund‐Iversen, G Berge, Odd Terje Brustugun, Steinar Solberg, Gunhild M. Mælandsmo, Kjetil Boye,
Abstract Background The metastasis-promoting protein S100A4 induces expression of ephrin-A1 and osteopontin in osteosarcoma cell lines. The aim of this study was to investigate S100A4-mediated stimulation of ephrin-A1 and osteopontin in non-small cell lung cancer (NSCLC) cell lines, and to characterize the expression of these biomarkers in primary tumor tissue from NSCLC patients. Methods Four NSCLC cell lines were treated with extracellular S100A4, and ephrin-A1 and osteopontin expression was analyzed ...
Tópico(s): Thyroid Cancer Diagnosis and Treatment
2012 - BioMed Central | BMC Cancer
Camilla Sagerup, Dag André Nymoen, Ann Rita Halvorsen, Marius Lund‐Iversen, Åslaug Helland, Odd Terje Brustugun,
Background. Unlike cervical, anogenital and oropharyngeal cancers, where high-risk human papillomavirus (hrHPV) has long been known to play a major role, a causative link between HPV and lung cancer has been investigated for decades with discrepant results.Methods. Lung cancer patients eligible for surgical treatment were tested for the presence of HPV-DNA in excised, fresh frozen lung tumor tissue. Patients that tested positive were further examined for the presence of HPV-DNA in adjacent normal ...
Tópico(s): Cancer-related molecular mechanisms research
2014 - Taylor & Francis | Acta Oncologica
Anna‐Lena Kjøniksen, Bo Nyström, Christian Iversen, Torgeir Nakken, Odd Palmgren, Terje Tande,
Viscosity measurements have been carried out on dilute acid aqueous solutions of chitosan and of hydrophobically modified chitosan (HM-chitosan) with three different degrees of C12-aldehyde substitution. The experiments were performed in the presence of different amounts of the cationic surfactant cetyltrimethylammonium bromide (CTAB) (0−30 mm) and with and without salt addition. By using Huggins equation, the intrinsic viscosity [η], and Huggins constant (k') were evaluated at different conditions. ...
Tópico(s): Polymer Surface Interaction Studies
1997 - American Chemical Society | Langmuir
Åsa Kristina Öjlert, Ann Rita Halvorsen, Daniel Nebdal, Marius Lund‐Iversen, Steinar Solberg, Odd Terje Brustugun, Ole Christian Lingjærde, Åslaug Helland,
The impact of the tumor immune microenvironment on overall survival in non‐small cell lung cancer ( NSCLC ) has been studied, but there is little information on its relevance for risk of relapse after surgery. Understanding more about the immune microenvironment in previously untreated NSCLC could help in identifying high‐risk patients and patients more likely to benefit from neoadjuvant/adjuvant immunotherapy. Here, we examined gene expression in 399 surgically derived NSCLC samples and 47 samples ...
Tópico(s): Radiomics and Machine Learning in Medical Imaging
2019 - Elsevier BV | Molecular Oncology
Bjørn Henning Grønberg, Marius Lund‐Iversen, Erik H. Strøm, Odd Terje Brustugun, Helge Scott,
Introduction Pemetrexed is effective in the treatment of non–small-cell lung cancer, mainly in nonsquamous cell carcinomas. Inhibition of thymidylate synthase (TS) is considered the key mechanism of action. Folate receptor-α facilitates uptake of pemetrexed. Polyglutamation by folylpolyglutamate synthetase enhances activity and prolongs cellular retention of pemetrexed. Thyroid transcription factor-1 (TTF-1) is mainly positive in nonsquamous cell carcinoma and has been proposed as a marker for sensitivity to ...
Tópico(s): Cholangiocarcinoma and Gallbladder Cancer Studies
2013 - Elsevier BV | Journal of Thoracic Oncology
Anna‐Lena Kjøniksen, Christian Iversen, Bo Nyström, Torgeir Nakken, Odd Palmgren,
Intensity (ILS) and dynamic light scattering (DLS) experiments were performed on semidilute acid aqueous solutions of unmodified chitosan (UM-chitosan) and of hydrophobically modified chitosan (HM-chitosan) with two different degrees of C12-aldehyde substitution. Both the ILS and the DLS measurements suggest the formation of association structures. According to the ILS measurements in the range qξ > 1 (q is the wave vector and ξ is the correlation length), all the systems have a fractal structure and the ...
Tópico(s): Electrostatics and Colloid Interactions
1998 - American Chemical Society | Macromolecules
Marius Lund‐Iversen, Lilach Kleinberg, Lars Fjellbirkeland, Åslaug Helland, Odd Terje Brustugun,
Introduction:The characteristics of different types of epidermal growth factor receptor (EGFR) gene mutations in non–small-cell lung cancer (NSCLC) are not extensively studied. The distribution of EGFR mutations is known, with the most frequent in exon 19 (deletions) or exon 21 (point mutations). Aberrations in exon 18 or 20 are infrequently found. Point mutations in exon 20 confer resistance against tyrosine kinase inhibitors (TKIs), whereas the effect of the rare exon 20 insertions is, to a lesser ...
Tópico(s): Lung Cancer Research Studies
2012 - Elsevier BV | Journal of Thoracic Oncology
Marc McGowan, Aleksandra Silye Hoven, Marius Lund‐Iversen, Steinar Solberg, Åslaug Helland, Fred R. Hirsch, Odd Terje Brustugun,
Objectives Mutation in the PIK3CA gene is reported frequent in squamous cell carcinomas of the lung, but its potential prognostic role is still obscure. We have studied the prognostic importance of PIK3CA mutations as well as the relation to other markers in a large number of early stage lung cancers of squamous carcinoma subtype. Patients and methods Tumour tissue was obtained from 308 consecutively operated lung cancer patients with squamous cell carcinoma in the period 2003–2013. DNA was isolated ...
Tópico(s): Cancer Genomics and Diagnostics
2016 - Elsevier BV | Lung Cancer
Christian Iversen, Anna‐Lena Kjøniksen, Bo Nyström, Torgeir Nakken, Odd Palmgren, Terje Tande,
Tópico(s): Rheology and Fluid Dynamics Studies
1997 - Springer Science+Business Media | Polymer Bulletin
Martin Peifer, Lynnette Fernández-Cuesta, Martin L. Sos, Julie George, Danila Seidel, Lawryn H. Kasper, Dennis Plenker, Frauke Leenders, Ruping Sun, Thomas Zander, Roopika Menon, Mirjam Koker, Ilona Dahmen, Christian Müller, Vincenzo Di Cerbo, Hans‐Ulrich Schildhaus, Janine Altmüller, Ingelore Baessmann, Christian Becker, Bram De Wilde, Jo Vandesompele, Diana Böhm, Sascha Ansén, Franziska Gabler, Ines Wilkening, Stefanie Heynck, Johannes M. Heuckmann, Xin Lü, Scott L. Carter, Kristian Cibulskis, Shantanu Banerji, Gad Getz, Kwon-Sik Park, Daniel Rauh, Christian Grütter, Matthias Fischer, Laura Pasqualucci, Gavin Wright, Zoe Wainer, Prudence A. Russell, Iver Petersen, Yuan Chen, Erich Stoelben, Corinna Ludwig, Philipp A. Schnabel, Hans Hoffmann, Thomas Muley, Michael Brockmann, Walburga Engel-Riedel, Lucia Anna Muscarella, Vito Michele Fazio, Harry J.M. Groen, Wim Timens, Hannie Sietsma, Erik Thunnissen, Egbert F. Smit, Daniëlle A.M. Heideman, Peter J.F. Snijders, Federico Cappuzzo, Claudia Ligorio, Stefania Damiani, John K. Field, Steinar Solberg, Odd Terje Brustugun, Marius Lund‐Iversen, Jörg Sänger, Joachim H. Clement, Alex Soltermann, Holger Moch, Walter Weder, Benjamin Solomon, Jean‐Charles Soria, Pierre Validire, Benjamin Besse, Élisabeth Brambilla, Christian Brambilla, Sylvie Lantuéjoul, Philippe Lorimier, Peter M. Schneider, Michael Hallek, William Pao, Matthew Meyerson, Julien Sage, Jay Shendure, Robert C. Schneider, Reinhard Büttner, Jürgen Wolf, Peter Nürnberg, Sven Perner, Lukas C. Heukamp, Paul K. Brindle, Stefan A. Haas, Roman K. Thomas,
Roman Thomas and colleagues report exome sequencing of 29 small-cell lung cancers (SCLCs), 2 SCLC genomes and transcriptomes of 15 SCLCs. They identify recurrent mutations in the CREBBP, EP300 and MLL genes encoding histone modifiers. They identify mutations in SLIT2 and EPHA7, which have a role in axon guidance and cell migration, and focal amplifications of FGFR1. Small-cell lung cancer (SCLC) is an aggressive lung tumor subtype with poor prognosis1,2,3. We sequenced 29 SCLC exomes, 2 genomes and ...
Tópico(s): Neuroendocrine Tumor Research Advances
2012 - Nature Portfolio | Nature Genetics
K. J. Nilssen, Odd A. Gulseth, Martin Haugmo Iversen, R. Kjol,
Anadromous Arctic charr (Salvelinus alpinus L.) were caught on their way to and from the sea with the use of a fish trap placed in the Dieset watercourse located on the Spitsbergen Island (79 degrees 10' Northern latitude) within the high-Arctic Svalbard archipelago. When subjected to a seawater challenge test (34 parts/thousand at 4-5 degrees C), charr on their way to the sea showed only minor and temporary changes in blood plasma osmolality and Na+ and Mg2+ concentrations. The seawater tests also ...
Tópico(s): Fish Ecology and Management Studies
1997 - American Physiological Society | AJP Regulatory Integrative and Comparative Physiology
Julie George, Vonn Walter, Martin Peifer, Ludmil B. Alexandrov, Danila Seidel, Frauke Leenders, Lukas Maas, Christian Müller, Ilona Dahmen, Tiffany M. Delhomme, Maude Ardin, Noémie Leblay, Graham Byrnes, Ruping Sun, Aurélien de Reyniès, Anne McLeer‐Florin, Graziella Bosco, Florian Malchers, Roopika Menon, Janine Altmüller, Christian Becker, Peter Nürnberg, Viktor Achter, Ulrich Lang, Peter M. Schneider, Magdalena Bogus, Matthew G. Soloway, Matthew D. Wilkerson, Yupeng Cun, James McKay, Denis Moro‐Sibilot, Christian Brambilla, Sylvie Lantuéjoul, Nicolas Lemaître, Alex Soltermann, Walter Weder, Verena Tischler, Odd Terje Brustugun, Marius Lund‐Iversen, Åslaug Helland, Steinar Solberg, Sascha Ansén, Gavin Wright, Benjamin Solomon, Luca Roz, Ugo Pastorino, Iver Petersen, Joachim H. Clement, Jörg Sänger, Jürgen Wolf, Martin Vingron, Thomas Zander, Sven Perner, William D. Travis, Stefan A. Haas, Magali Olivier, Matthieu Foll, Reinhard Büttner, D. Neil Hayes, Élisabeth Brambilla, Lynnette Fernández-Cuesta, Roman K. Thomas,
Pulmonary large-cell neuroendocrine carcinomas (LCNECs) have similarities with other lung cancers, but their precise relationship has remained unclear. Here we perform a comprehensive genomic (n = 60) and transcriptomic (n = 69) analysis of 75 LCNECs and identify two molecular subgroups: "type I LCNECs" with bi-allelic TP53 and STK11/KEAP1 alterations (37%), and "type II LCNECs" enriched for bi-allelic inactivation of TP53 and RB1 (42%). Despite sharing genomic alterations with adenocarcinomas and squamous ...
Tópico(s): Lung Cancer Treatments and Mutations
2018 - Nature Portfolio | Nature Communications
Nicolas Alcala, Noémie Leblay, Alice‐Agnes Gabriel, Lise Mangiante, David Hervás, Théo Giffon, Anne-Sophie Sertier, Anthony Ferrari, Jules L. Derks, A. Ghantous, Tiffany M. Delhomme, Amélie Chabrier, Cyrille Cuenin, Behnoush Abedi‐Ardekani, Anne Boland, Robert Olaso, Vincent Meyer, Janine Altmüller, Florence Le Calvez‐Kelm, Geoffroy Durand, Catherine Voegele, Sandrine Boyault, Laura Moonen, Nicole Lemaître, P. Lorimier, Anne‐Claire Toffart, Alex Soltermann, Joachim H. Clement, Joerg Saenger, John K. Field, Marie Brevet, Cécile Blanc‐Fournier, Françoise Galateau-Sallé, Nolwenn Le Stang, Prudence A. Russell, Gavin Wright, Gabriella Sozzi, Ugo Pastorino, Stéphanie Lacomme, J Vignaud, Véronique Hofman, Paul Hofman, Odd Terje Brustugun, Marius Lund‐Iversen, Vincent de Montpréville, Lucia Anna Muscarella, Paolo Graziano, Helmut Popper, Jelena Stojšić, Jean‐François Deleuze, Zdenko Herceg, Alain Viari, Peter Nüernberg, Giuseppe Pelosi, Anne‐Marie C. Dingemans, Massimo Milione, Luca Roz, Luka Brčić, Marco Volante, Mauro Papotti, Christophe Caux, Juan Sandoval, Héctor Hernández‐Vargas, Élisabeth Brambilla, E.J.M. Speel, Nicolas Girard, Sylvie Lantuéjoul, James McKay, Matthieu Foll, Lynnette Fernández-Cuesta,
Abstract The worldwide incidence of pulmonary carcinoids is increasing, but little is known about their molecular characteristics. Through machine learning and multi-omics factor analysis, we compare and contrast the genomic profiles of 116 pulmonary carcinoids (including 35 atypical), 75 large-cell neuroendocrine carcinomas (LCNEC), and 66 small-cell lung cancers. Here we report that the integrative analyses on 257 lung neuroendocrine neoplasms stratify atypical carcinoids into two prognostic groups ...
Tópico(s): Neuroblastoma Research and Treatments
2019 - Nature Portfolio | Nature Communications
... j.1468-0114.2007.00290.xArco Timmermans, T Iversen Coalition Governance in Belgium and The Netherlands: Rising Government Stability Against All Electoral Odds, Acta Politica 41, no.44 (Dec 2006): 389– ...
Tópico(s): Political Philosophy and Ethics
1993 - University of Chicago Press | Ethics
Janna Berg, Lars Fjellbirkeland, Pål Suhrke, Peter Jebsen, Marius Lund‐Iversen, Lilach Kleinberg, Lars Helgeland, Odd Terje Brustugun, Åslaug Helland,
Background. Patients with advanced stage lung cancer and somatic mutations in the epithelial growth factor receptor (EGFR) gene are currently treated with tyrosine-kinase inhibitors. The Norwegian Lung Cancer Group (NLCG) recommended EGFR testing of all patients with non-small cell lung carcinoma (NSCLC) from June 2010. From March 2013, testing of squamous cell carcinomas was terminated. We have analysed how these recommendation were followed at a medium-sized Norwegian hospital and we present data ...
Tópico(s): Cancer Genomics and Diagnostics
2015 - Taylor & Francis | Acta Oncologica
Åsa Kristina Öjlert, Daniel Nebdal, Marius Lund‐Iversen, Renée Åstrøm Ellefsen, Odd Terje Brustugun, Jon Michael Gran, Ann Rita Halvorsen, Åslaug Helland,
Background The implementation of immune checkpoint inhibitors (ICI) into the standard care of advanced non-small cell lung cancer (NSCLC) has improved prognosis for this group of patients. However, long-term survival is rare. The aim of the study was to identify predictors of response and, especially, to investigate the impact radiotherapy might have on duration of response.Material and methods The association between pretreatment patient/tumor characteristics and progression-free survival (PFS), overall ...
Tópico(s): Inflammatory Biomarkers in Disease Prognosis
2020 - Taylor & Francis | Acta Oncologica
Anne Pernille Harlem Dyrbekk, Abdirashid Warsame, Pål Suhrke, Marianne Odnakk Ludahl, Joakim Oliu Moe, Inger Johanne Zwicky Eide, Marius Lund‐Iversen, Odd Terje Brustugun,
ROS1 fusion is an infrequent, but attractive target for therapy in patients with metastatic non- small-cell lung cancer. In studies on mainly late-stage disease, the prevalence of ROS1 fusions is about 1-3%. In early-stage lung cancer ROS1 might also provide a fruitful target for neoadjuvant or adjuvant therapy. In the present study, we investigated the prevalence of ROS1 fusion in a Norwegian cohort of early-stage lung cancer. We also explored whether positive ROS1 immunohistochemical (IHC) stain ...
Tópico(s): Cancer Genomics and Diagnostics
2023 - BioMed Central | Diagnostic Pathology
Inger Johanne Zwicky Eide, Yngvar Nilssen, Marius Lund‐Iversen, Odd Terje Brustugun,
Long-term data on disease trajectory of EGFR-mutated early-stage non-small cell lung cancer (NSCLC) is still limited. This is relevant in the context of the recently approved introduction of adjuvant EGFR-targeting therapy, specifically osimertinib in resected stage II-III EGFR-mutated NSCLC.Long-term data on patients with resected adenocarcinoma of the lung and known EGFR-status were analysed with focus on site of relapse and detailed cause of death. Patients resected in the period 2006 to 2018 ...
Tópico(s): Lung Cancer Research Studies
2022 - Taylor & Francis | Acta Oncologica
Ane Kongsgaard, Kjetil Boye, Miriam Øijordsbakken, Marius Lund‐Iversen, Ann Rita Halvorsen, Steinar Solberg, G Berge, Åslaug Helland, Odd Terje Brustugun, Gunhild M. Mælandsmo,
Abstract Background In a previously published report we characterized the expression of the metastasis-associated proteins S100A4, osteopontin (OPN) and ephrin-A1 in a prospectively collected panel of non-small cell lung cancer (NSCLC) tumors. The aim of the present follow-up study was to investigate the prognostic impact of these potential biomarkers in the same patient cohort. In addition, circulating serum levels of OPN were measured and single nucleotide polymorphisms (SNP) in the -443 position ...
Tópico(s): Cancer, Hypoxia, and Metabolism
2013 - BioMed Central | BMC Cancer
Henrik Auråen, Hans Henrik Lawaetz Schultz, Pekka Hämmäinen, Gerdt C. Riise, Hillevi Larsson, Lennart Hansson, Göran Dellgren, Michael Perch, Odd Geiran, Arnt E. Fiane, Martin Iversen, Are Martin Holm,
Throughout the world, the scarcity of donor organs makes optimal allocation systems necessary. In the Scandiatransplant countries, organs for lung transplantation are allocated nationally. To ensure shorter wait time for critically ill patients, the Scandiatransplant urgent lung allocation system (ScULAS) was introduced in 2009, giving supranational priority to patients considered urgent. There were no pre-defined criteria for listing a patient as urgent, but each center was granted only 3 urgent ...
Tópico(s): Renal Transplantation Outcomes and Treatments
2018 - Elsevier BV | The Journal of Heart and Lung Transplantation
Marius Lund‐Iversen, Helge Scott, Erik H. Strøm, Noah Theiss, Odd Terje Brustugun, Bjørn Henning Grønberg,
Background/Aim: The favorable prognosis of women with non-small-cell lung cancer (NSCLC) compared to men might be explained by sex hormone-related mechanisms. We investigated whether this observation could be explained by the expression of estrogen receptor-alpha (ER-α) in tumor tissue. Materials and Methods: Archived, formalin fixed, paraffin embedded tumor tissue samples were retrospectively analyzed for nuclear expression of ER-α with immunohistochemistry. Results: Biopsies from 222 patients were ...
Tópico(s): Cytokine Signaling Pathways and Interactions
2018 - International Institute of Anticancer Research (IIAR) Conferences 1997. Athens, Greece. Abstracts | Anticancer Research
Marius Lund‐Iversen, Krystyna Grøholt, Åslaug Helland, Elin Borgen, Odd Terje Brustugun,
Nuclear protein in testis (NUT) midline carcinomas (NMC) are rare, highly aggressive epithelial neoplasms, characterised by protein expression of NUT-fusion proteins which reflects the genetic translocation between chromosome 15 and 19. NMC occurs mainly in midline structures, but there are reports regarding occurrence in structures outside the midline. We investigated specimens from 519 surgically resected lung carcinomas and carcinoid tumours for the presence of NUT protein using immunohistochemistry. ...
Tópico(s): Ubiquitin and proteasome pathways
2015 - BioMed Central | Diagnostic Pathology
Danila Seidel, Thomas Zander, Lukas C. Heukamp, Martin Peifer, Marc Bos, Lynnette Fernández-Cuesta, Frauke Leenders, Xin Lü, Sascha Ansén, Masyar Gardizi, Chau Nguyen, Johannes Berg, Prudence A. Russell, Zoe Wainer, Hans‐Ulrich Schildhaus, Toni-Maree Rogers, Benjamin Solomon, William Pao, Scott L. Carter, Gad Getz, D. Neil Hayes, Matthew D. Wilkerson, Erik Thunnissen, William D. Travis, Sven Perner, Gavin Wright, Élisabeth Brambilla, Reinhard Buettner, Juergen Wolf, Roman K. Thomas, Franziska Gabler, Ines Wilkening, Christian Mueller, Ilona Dahmen, Roopika Menon, Katharina Koenig, Kerstin Albus, Sabine Merkelbach‐Bruse, Jana Fassunke, Katja Schmitz, Helen Kuenstlinger, Michaela Angelika Kleine, Elke Binot, Silvia Querings, Janine Altmueller, Ingelore Boessmann, Peter Nuemberg, Peter M. Schneider, Magdalena Bogus, Alex Soltermann, Holger Moch, Odd Terje Brustugun, Steinar Solberg, Marius Lund‐Iversen, Åslaug Helland, Thomas Muley, Hans Hoffmann, Philipp A. Schnabel, Yuan Chen, Harry J.M. Groen, Wim Timens, Hannie Sietsma, Joachim H. Clement, Walter Weder, Joerg Saenger, Erich Stoelben, Corinna Ludwig, Walburga Engel-Riedel, Egbert F. Smit, Danille A. M. Heideman, Peter J.F. Snijders, Lucia Nogová, Martin L. Sos, Christian Mattonet, Karin Toepelt, Matthias Scheffler, Eray Goekkurt, Rainer Kappes, Stefan Krueger, Kato Kambartel, Dirk Behringer, Wolfgang Schulte, Wolfgang Galetke, Winfried Randerath, Matthias Heldwein, Andreas Schlesinger, Monika Serke, Khosro Hekmat, Konrad Frank, Roland Schnell, Marcel Reiser, Ali-Nuri Huenerlituerkoglu, Stephan Schmitz, Lisa Meffert, Yon‐Dschun Ko, Markus Litt-Lampe, Ulrich Gerigk, Rainer Fricke, Benjamin Besse, Christian Brambilla, Sylvie Lantuéjoul, Philippe Lorimier, Denis Moro‐Sibilot, Federico Cappuzzo, Claudia Ligorio, Stefania Damiani, John K. Field, R. Katherine Hyde, Pierre Validire, Philippe Girard, Lucia Anna Muscarella, Vito Michele Fazio, Michael Hallek, Jean‐Charles Soria, Viktor Achter, Ulrich Lang,
The pattern of mutations in human lung cancer differs by tumor subtype and is a useful addition to histology for selecting targeted therapy and improving patient survival.
Tópico(s): Cholangiocarcinoma and Gallbladder Cancer Studies
2013 - American Association for the Advancement of Science | Science Translational Medicine
T. Donnem, Thomas K. Kilvaer, Sigve Andersen, Elin Richardsen, Erna‐Elise Paulsen, Sigurd M. Hald, Samer Al‐Saad, Odd Terje Brustugun, Åslaug Helland, Marius Lund‐Iversen, Steinar Solberg, Bjørn Henning Grønberg, Sissel Gyrid Freim Wahl, Lars Helgeland, Øystein Fløtten, Mette Pøhl, Khalid Al‐Shibli, Torkjel M. Sandanger, Francesco Pezzella, L. T. Busund, Roy M. Bremnes,
ABSTRACT Immunoscore is a prognostic tool defined to quantify in situ immune cell infiltrates and appears highly promising as a supplement to the tumor–node–metastasis (TNM) classification of various tumors. In colorectal cancer, an international task force has initiated prospective multicenter studies aiming to implement TNM-Immunoscore (TNM-I) in a routine clinical setting. In breast cancer, recommendations for the evaluation of tumor-infiltrating lymphocytes (TILs) have been proposed by an international ...
Tópico(s): Inflammatory Biomarkers in Disease Prognosis
2015 - Elsevier BV | Annals of Oncology
Tom Dønnem, Sigurd M. Hald, Erna‐Elise Paulsen, Elin Richardsen, Samer Al‐Saad, Thomas K. Kilvaer, Odd Terje Brustugun, Åslaug Helland, Marius Lund‐Iversen, Mette Poehl, Karen Ege Olsen, Henrik J. Ditzel, Olfred Hansen, Khalid Al‐Shibli, Yury Kiselev, Torkjel M. Sandanger, Sigve Andersen, Francesco Pezzella, Roy M. Bremnes, Lill‐Tove Busund,
Abstract Purpose: Immunoscore is a prognostic tool defined to quantify in situ immune cell infiltrates, which appears to be superior to the tumor–node–metastasis (TNM) classification in colorectal cancer. In non–small cell lung cancer (NSCLC), no immunoscore has been established, but in situ tumor immunology is recognized as highly important. We have previously evaluated the prognostic impact of several immunological markers in NSCLC, yielding the density of stromal CD8+ tumor-infiltrating lymphocytes ( ...
Tópico(s): Colorectal and Anal Carcinomas
2015 - American Association for Cancer Research | Clinical Cancer Research