National Bureau of Economic Research (NBER)
Sushruta Koppula, Mun-Jeong Yum, Jin-Seoub Kim, Gwang-Mo Shin, Yun-Jin Chae, Tony Yoon, Chi-Su Chun, Jae-Dong Lee, Min-Dong Song,
... the anti-fibrotic effects of O. japonicus extract (OJE) in cellular and experimental hepatofibrotic rat models were ... divided into five groups (n = 8): Control, TAA, OJE 10 (TAA with OJE 10 mg/kg), OJE 100 (TAA with OJE 100 mg/kg) and silymarin (TAA with Silymarin ... p.) twice per week for 13 weeks, while OJE and silymarin were administered orally two times per ... PCR and spectrophotometry, respectively, using commercial kits.RESULTS: OJE (0.5 and 0.1 mg/ mL) and ... induced apoptosis (16.95% and 27.48% for OJE and 25.87% for silymarin, respectively) in HSC- ...
Tópico(s): Drug Transport and Resistance Mechanisms
2017 - | Nutrition Research and Practice
National Bureau of Economic Research (NBER)
Jong-Dai Kim, Moo‐Ho Won, JoonHa Park, Inhye Kim, JiHyeon Ahn, Yoogyeong Oh, Sung‐Su Kim, Tae-Kyeong Lee, Jae‐Chul Lee, Bich‐Na Shin, Taehu Sim, Hyun-Sam Lee, Jeong-Hwi Cho, In Koo Hwang, Il‐Jun Kang,
Recently, we have reported that Oenanthe javanica extract (OJE) displays strong neuroprotective effect against ischemic damage after transient global cerebral ischemia. However, neuroprotective mechanisms of OJE have not been fully identified. Thus, this study investigated the neuroprotection of OJE in the hippocampal CA1 area and its anti- ... We treated the animals by intragastrical injection of OJE (100 and 200 mg/kg) once daily for ... prior to transient global cerebral ischemia. Neuroprotection of OJE was observed by immunohistochemistry for neuronal nuclear antigen ...
Tópico(s): Natural Compounds in Disease Treatment
2019 - Medknow | Neural Regeneration Research
Zixiong Zhou, Jing Qi, Jing Zhao, Jeong Hun Seo, Dong Gue Shin, Jeong‐Dan Cha, Chae Woong Lim, Jong-Won Kim, Bumseok Kim,
... the effects of ethanol extract of O. japonicus (OJE) on acetaminophen (N-acetyl-p-aminophenol, APAP) overdose- ... study was aimed to investigate the effects of OJE against APAP-induced acute liver injury (ALI) and ... the underlying mechanisms. Mice were treated orally with OJE (50, 100, or 200 mg/kg) for seven ... was also applied in this study. Pretreatment with OJE, especially at a dose of 200 mg/kg, ... aspartate aminotransferase levels, histopathological damage, and inflammation. Consistently, OJE pretreatment reduced the gene transcription of cytochrome P450 ( ...
Tópico(s): Pharmacogenetics and Drug Metabolism
2020 - Elsevier BV | Journal of Ethnopharmacology
Directory of Open Access Journals (DOAJ)
Jung Ho Kim, Sanghee Kim, Ramesh Mariappan, Daeun Moon, Jinu Kim, Sang Pil Yoon,
... cancer effects of aqueous extract of Orostachys japonica (OJe) have not yet been thoroughly investigated.To evaluate the anti-cancer effects of OJe, its possible mechanisms of action were investigated in ... FUR colorectal cancer cells.The functional compounds of OJe were identified with high performance liquid chromatography. The anti-cancer effects of OJe in SNU-C5/5-FUR cells were investigated ... Possible signalling pathways were assayed with Western blotting.OJe (250 μg/ml) showed anti-cancer effects in ...
Tópico(s): Natural product bioactivities and synthesis
2021 - Elsevier BV | Journal of Ethnopharmacology
Choong‐Hyun Lee, Joon-Ha Park, Jeong-Hwi Cho, In‐Hye Kim, JiHyeon Ahn, Jae‐Chul Lee, Bai Hui Chen, Bich‐Na Shin, Hyun‐Jin Tae, Eun Joo Bae, Il‐Jun Kang, Moo‐Ho Won, Jong-Dai Kim,
... We examined the effect of O. javanica extract (OJE) on antioxidant enzymes in the rat liver.We examined the effect of the OJE on copper, zinc-superoxide dismutase (SOD1), manganese superoxide ... group) as a positive control, (3) diet containing OJE-fed group (OJE-group).In this study, no histopathological finding in ... normal-group. On the other hand, in the OJE-group, numbers of SOD1, SOD2, CAT, and GPx ... of SOD1, SOD2, CAT, and GPx in the OJE-group were also significantly much higher than those in the AA-group.OJE significantly increased expressions of SOD1 and SOD2, CAT, ...
Tópico(s): Ginger and Zingiberaceae research
2015 - Lippincott Williams & Wilkins | Chinese Medical Journal
Tae Hyun-Jin, Joon Ha Park, Cho Jeong-Hwi, In Hye Kim, Ji Hyeon Ahn, Jae Chul Lee, Jong-Dai Kim, Jinseu Park, Soo Young Choi, Won Moo-Ho,
... investigate the effect of the Oenanthe javanica extract (OJE) in the rat kidney using immunohistochemistry for antioxidant ... AAgroup) as a positive control, (3) diet containing OJE-fed group (OJE-group). AA and OJE were supplied during 28 days. Results The side- ... kidney, and their immunoreactivities in the AA- and OJE-groups were increased to about 1.4–1. ... compared with those in the normal-group. Conclusion OJE significantly increased expressions of SOD1 & 2, CAT and ... that significant enhancements of endogenous enzymatic antioxidants by OJE treatment may be a legitimate strategy for decreasing ...
Tópico(s): Energy and Environment Impacts
2014 - Lippincott Williams & Wilkins | Chinese Medical Journal
Joon Ha Park, Jeong Hwi Cho, In Hye Kim, Ji Hyeon Ahn, Jae‐Chul Lee, Bai Hui Chen, Bich‐Na Shin, Hyun‐Jin Tae, Ki‐Yeon Yoo, Seongkweon Hong, Il‐Jun Kang, Moo‐Ho Won, Jong-Dai Kim,
... examined the neuroprotective effect of Oenanthe javanica extract (OJE) in the hippocampal cornus ammonis 1 region (CA1 ... arteries for 5 min. The neuroprotective effect of OJE was estimated by cresyl violet staining. In addition, ... with 200 mg/kg, not 100 mg/kg, OJE protected CA1 pyramidal neurons from ischemic damage. In addition, 200 mg/kg OJE treatment increased or maintained antioxidants immunoreactivities. Especially, among ... increased in the CA1 pyramidal neurons of the OJE-treated sham-operated and ischemia-operated groups. Conclusion: ...
Tópico(s): Medicinal Plants and Neuroprotection
2015 - Lippincott Williams & Wilkins | Chinese Medical Journal
Giuseppe Montalbano, Manuela Mania, Maria Cristina Guerrera, Rosaria Laurà, Francesco Abbate, Maria Levanti, Alessandro Maugeri, Antonino Germanà, Michele Navarra,
... flavonoid-rich extract of orange (Citrus sinensis) juice (OJe) in diet-induced obese zebrafish.Adult zebrafish were ... NF); (ii) overfed (OF); (iii) NF supplemented with OJe (5 mL/L in fish water; NF + OJe); and (iv) OF supplemented with OJe (OF + OJe). Each week, body weight (BW) and body mass ... microscopic evaluations and qPCR analyses.In OF zebrafish, OJe significantly decreased both BW and BMI values and ... well as their number in OF fish. Finally, OJe modulated some obesity-related genes, such as leptin ...
Tópico(s): Ginseng Biological Effects and Applications
2019 - Multidisciplinary Digital Publishing Institute | International Journal of Molecular Sciences
Chris T. Stivers, Licheng Sun, Yong Sun,
... and subperiod evidence for the other January effect (OJE) documented in Cooper et al. [2006. The other ... Financial Economics 82, 315–341]. When examining the OJE in 22 countries starting as early as 1801, ... subsequent 11-month return spreads. Further, the international OJE spreads and the OJE spreads in disaggregate U.S.-style portfolios are ... specific or portfolio-specific January return. Finally, the OJE is weaker over the 1975–2006 post-discovery ... pre-discovery period. Our evidence indicates that the OJE is primarily a U.S. market-level-based ...
Tópico(s): Housing Market and Economics
2009 - Elsevier BV | Journal of Financial Markets
Anders Hansson, Julio C. Zelada, Hugo P. Noriega,
The anthelmintic remedy ojé, prepared latex of Ficus insipida, is still used by indigenous and local people in the Amazonian regions. However, overdosage ... year-old girl in Pucallpa, who had received ojé in a dose close to the recommended one, ... of all hospitalized patients with toxic reactions to ojé over a 12-year-period. The use of ojé in and around Pucallpa was estimated. Most cases ... 01–0.015% among patients supposedly treated with ojé in the area. Severe intoxication led to symptoms ... toxic reactions from an expected continued use of ojé.
Tópico(s): Psidium guajava Extracts and Applications
2005 - Elsevier BV | Journal of Ethnopharmacology
... exchange (LMX), work engagement (WE), organizational job embeddedness (OJE) and organizational citizenship behaviour (OCB) of employees in ... WE on IT employees’ citizenship behaviour mediated by OJE. Design/methodology/approach The sample has been taken ... been used to analyse the mediating role of OJE. Findings The study findings reveal significant association between the key study variables. Organizational job embeddedness (OJE partially mediated the relationship between organizational factors such ... useful insights to better understand the antecedents of OJE and how it influences employees’ citizenship behaviour. Exploring ...
Tópico(s): Customer Service Quality and Loyalty
2019 - Emerald Publishing Limited | Journal of Indian Business Research
... workplace fun, perceived workplace aggression, and organizational JE (OJE). It examines to what extent these relationships vary ... Workplace fun is positively associated with restaurant employees’ OJE while only coworker aggression is negatively related to employees’ OJE. Restaurant employees’ use of affiliative humor and aggressive ... fun, as well as between workplace fun and OJE. Our findings contribute to clarifying the dynamics between ... organizational factors for understanding when employees may develop OJE. The implication is that restaurant companies with international ...
Tópico(s): Communication in Education and Healthcare
2021 - SAGE Publishing | Journal of Hospitality & Tourism Research
Ui‐Jin Bae, Ha‐Na Jang, Sung Hyen Lee, Kyung Mo Kim, Gi-Chang Kim,
... colitis. First, treatment of O. javanica ethanol extract (OJE) inhibited the production of inflammatory cytokines in lipopolysaccharide- ... macrophages. Second, in mice with DSS-induced colitis, OJE administration reduced pathological damage to the colon while ... length, including inflammation and mucosal necrosis. In addition, OJE significantly (p < 0.01) restricted the activation of ... of fecal microbiota was markedly elevated in the OJE group. OJE administration reduced the abundance of Proteobacteria including Escherichia ...
Tópico(s): Genomics, phytochemicals, and oxidative stress
2022 - Multidisciplinary Digital Publishing Institute | Antioxidants
Seok-Jun Hwang, Sung Jin Park, Jong-Dai Kim,
... The concentrations of total phenol and flavonoids of OJE were $88.9{\pm}0.46$ mg GAE/ ... acid, catechin, chlorogenic acid, and caffeic acid in OJE as measured by using HPLC were $0.9{\ ... The DPPH and ABTS radical scavenging activities of OJE were 72.2%, and 66.1%, respectively, at $ ... g/mL$ . The FRAP and reducing power of OJE were 0.79, and 0.41 absorbance units value respectively, at $1,000{\mu}g/mL$ . OJE possessed significant antioxidant properties, which suggests its great ...
Tópico(s): Natural product bioactivities and synthesis
2013 - Korean Society of Food Science and Technology | Korean Journal of Food Science and Technology
A study of Yoruba Ss from traditional (OJE) and educated (ELITE) homes suggested that the advantage of economically and intellectually privileged socialisation was greatest at three years of age but diminished ... assessing threeand-a-half to eight-year-old OJE and ELITE Ss on a Stanford Binet Intelligence ... coefficient indicating steeper growth under five years for OJE Ss and an absolutely steeper curve for ELITE ... five years was noted. An intervention program for OJE Ss was proposed to compensate for the intellectual ...
Tópico(s): Psychological and Educational Research Studies
1971 - SAGE Publishing | Journal of Cross-Cultural Psychology
Ben R. Marshall, Nuttawat Visaltanachoti,
The Other January Effect (OJE), which suggests positive (negative) equity market returns in January predict positive (negative) returns in the following 11 months of the ... and after risk-adjustment. Even the best modified OJE strategy, which benefits from several ex-post adjustments, ... statistically or economically significant excess returns. When the OJE is tested with a method that is consistent with investor experience it is clear the OJE is no more profitable than an 11-month ...
Tópico(s): Auditing, Earnings Management, Governance
2010 - Elsevier BV | Journal of Banking & Finance
Seon‐Hee Kim, Deok‐Seon Ryu, Hyeong-Seon Lee, Hye-Ryoung Shin, Jihye Kwon, Dong‐Seok Lee,
... of the ethyl acetate fraction of O. japonicus (OJE) after the oral administration in Balb/c mice ... and organ weight. The LD50 of orally administered OJE was higher than 2000 mg/kg/d in ... sexes. These finding suggest that oral administration of OJE does not produce acute toxicity. Therefore, these results ... to launch clinical trials on standardized formulation of OJE to be a biohealth product.
Tópico(s): Ginseng Biological Effects and Applications
2014 - Taylor & Francis | Pharmaceutical Biology
Rita Citraro, Michele Navarra, Antonio Leo, Eugenio Donato Di Paola, E Santangelo, Pellegrino Lippiello, Rossana Aiello, Emilio Russo, Giovambattista De Sarro,
... of a flavonoid-rich extract from orange juice (OJe) in some rodent models of epilepsy and to ... of depression were used. Our results demonstrate that OJe was able to exert anticonvulsant effects on AGS- ... findings suggest that the anti-convulsant effects of OJe are likely mediated by both an inhibition of ... study provides evidences for the antiepileptic activity of OJe, and its results could be used as scientific ...
Tópico(s): GABA and Rice Research
2016 - Multidisciplinary Digital Publishing Institute | Molecules
Ji Hyun Kim, Gi Suk Nam, Sung Hyun Kim, Deok‐Seon Ryu, Dong‐Seok Lee,
... quercetin, kaempferol, and flavonol glycosides from O. japonicus (OJE) exhibited significant anticancer activity against the PANC-1. OJE activated caspase-3, caspase-8, and caspase-9, ... G1/S and G2/M phases. In addition, OJE phosphorylated MAPKs such as p38, JNK, and ERK, ... arrest of cell cycle inducing system. In conclusion, OJE effectively exerted antipancreatic cancer activity via induction of ...
Tópico(s): Cell death mechanisms and regulation
2019 - Wiley | Food Science & Nutrition
Roberta Fusco, Santa Cirmi, Enrico Gugliandolo, Rosanna Di Paola, Salvatore Cuzzocrea, Michele Navarra,
... of a flavonoid-rich extract of orange juice (OJe) in mice exposed to experimental colitis. Four days ... caused colitis in mice. Daily oral administration of OJe decreased the loss of body weight caused by ... Bcl-2 and Bax. Our results indicate that OJe may be used as functional food in case ...
Tópico(s): Tea Polyphenols and Effects
2017 - Elsevier BV | Journal of Functional Foods
... explains the mediating role of organizational job embeddedness (OJE) on the relationship between LMX and OCB in ... significant relationship among the key study variables. The OJE was found to partially mediate the LMX–OCB ... suggest that the organizations can proactively enhance both OJE and OCB through high quality of LMX. The ...
Tópico(s): Organizational Leadership and Management Strategies
2018 - SAGE Publishing | South Asian Journal of Human Resources Management
Kyung‐Sun Lee, S. Kim, Hyeong‐Seon Lee,
... the ethyl acetate fraction from O. japonicus extract (OJE) on the growth inhibition of OVCAR-3 human ... regulating the expression of pro-caspase-3. Furthermore, OJE treatment elicited p-p38 activation and p-ERK1/2 inhibition. In conclusion, our results demonstrated that OJE reduced the growth of OVCAR-3 human ovarian ...
Tópico(s): Bioactive Compounds and Antitumor Agents
2018 - Wiley | Food Science & Nutrition
Santa Cirmi, Basilio Randazzo, Caterina Russo, Laura Musumeci, Alessandro Maugeri, Giuseppe Montalbano, Maria Cristina Guerrera, Giovanni Enrico Lombardo, Maria Levanti,
... of a flavonoid-rich extract of orange juice (OJe) in an experimental model of enteritis induced by ... enteritis in zebrafish. Three days of treatment with OJe before the pathogenic insult resulted in a remarkable ... IL-6 and TNFα. Our data suggest that OJe counteracts the inflammation of zebrafish intestinal mucosa, indicating ...
Tópico(s): Neuroinflammation and Neurodegeneration Mechanisms
2020 - Taylor & Francis | Natural Product Research
Roberta Fusco, Santa Cirmi, Enrico Gugliandolo, Rosanna Di Paola, Salvatore Cuzzocrea, Michele Navarra,
... of a flavonoid-rich extract of orange juice (OJe) in mice exposed to experimental colitis. Four days ... caused colitis in mice. Daily oral administration of OJe decreased the loss of body weight caused by ... Bcl-2 and Bax. Our results indicate that OJe may be used as functional food in case ...
Tópico(s): Genomics, phytochemicals, and oxidative stress
2017 - Elsevier BV | Free Radical Biology and Medicine
Alex I. Oje, A. A. Ogwu, Mojtaba Mirzaeian, A.M. Oje, Nathaniel Tsendzughul,
The potential of a radio frequency (RF) magnetron sputtered silver (Ag) thin film electrodes, for electrochemical energy storage application is presented in this paper. Scanning electron microscope (SEM) was used to reveal the information on the morphology and growth mode of the deposited silver thin film samples. The stoichiometry of the RF sputtered silver thin films was evaluated using X-ray diffraction (XRD), while the elemental constituents of the deposited thin films were confirmed using energy ...
Tópico(s): Advanced battery technologies research
2019 - Elsevier BV | Applied Surface Science
A. Miles, P. Bentley, Joseph E Grey, Andreas Polychronis,
... of Westminster 33 Queen Anne Street London W1M OJE UKSearch for more papers by this authorP. Bentley ... of Westminster 33 Queen Anne Street London W1M OJE UKSearch for more papers by this authorP. Bentley ...
Tópico(s): Healthcare cost, quality, practices
1995 - Wiley | Journal of Evaluation in Clinical Practice