Xiaojing Liu, Jason W. Locasale,
... tumors is unknown. In this issue of EBioMedicine, Okegawa et al. use metabolomics to not only demonstrate ... metabolic differences within regions of the same tumor (Okegawa et al., 2017Okegawa T. Morimoto M. Nishizawa S. ... Full Text PDF Scopus (146) Google Scholar). Now Okegawa et al. not only characterized distinct metabolic profiles ... imply that the pathways identified are required. Therefore, Okegawa et al. treated patient kidney tumor derived cell ... some kidney cancers. Beyond identifying this therapeutic target, Okegawa et al. further showed that distinct metabolic patterns ...
Tópico(s): Pancreatic and Hepatic Oncology Research
2017 - Elsevier BV | EBioMedicine
Takatsugu Okegawa, Yingming Li, Rey-Chen Pong, Jer‐Tsong Hsieh,
... Apr 2002Cell Adhesion Proteins As Tumor Suppressors Takatsugu Okegawa, Yingming Li, Rey-Chen Pong, and Jer-Tsong Hsieh Takatsugu OkegawaTakatsugu Okegawa , Yingming LiYingming Li , Rey-Chen PongRey-Chen Pong , ... Inc.Keywordsurologic neoplasmscell adhesion moleculesurinary tractMetricsAuthor Information Takatsugu Okegawa More articles by this author Yingming Li More ...
Tópico(s): Galectins and Cancer Biology
2002 - Lippincott Williams & Wilkins | The Journal of Urology
Yingming Li, Takatsugu Okegawa, Donald P. Lombardi, Eugene P. Frenkel, Jer‐Tsong Hsieh,
... THERAPY BY TAXANE CHEMOTHERAPEUTIC AGENTS YINGMING LI, TAKATSUGU OKEGAWA, DONALD P. LOMBARDI, EUGENE P. FRENKEL, and JER- ... LI More articles by this author , TAKATSUGU OKEGAWATAKATSUGU OKEGAWA More articles by this author , DONALD P. LOMBARDIDONALD ... YINGMING LI More articles by this author TAKATSUGU OKEGAWA More articles by this author DONALD P. LOMBARDI ...
Tópico(s): Ubiquitin and proteasome pathways
2002 - Lippincott Williams & Wilkins | The Journal of Urology
Takatsugu Okegawa, Kikuo Nutahara, Eiji Higashihara,
... Invasiveness and Growth of Prostate Cancer Cells Takatsugu Okegawa, Kikuo Nutahara, and Eiji Higashihara Takatsugu OkegawaTakatsugu Okegawa , Kikuo NutaharaKikuo Nutahara , and Eiji HigashiharaEiji Higashihara View ... neoplasmsprostate-specific antigenneoplasm metastasisneoplasm circulating cellsMetricsAuthor Information Takatsugu Okegawa More articles by this author Kikuo Nutahara More ...
Tópico(s): Radiation Therapy and Dosimetry
2008 - Lippincott Williams & Wilkins | The Journal of Urology
Takatsugu Okegawa, Kikuo Nutahara, Rey-Chen Pong, Eiji Higashihara, Jer‐Tsong Hsieh,
... CANCER GENE THERAPY WITH HISTONE DEACETYLASE INHIBITOR TAKATSUGU OKEGAWA, KIKUO NUTAHARA, REY-CHEN PONG, EIJI HIGASHIHARA, and JER-TSONG HSIEH TAKATSUGU OKEGAWATAKATSUGU OKEGAWA , KIKUO NUTAHARAKIKUO NUTAHARA , REY-CHEN PONGREY-CHEN PONG , ... Association, Inc.Keywordsbladderhistone deacetylasesbladder neoplasmsadenovirus receptorMetricsAuthor Information TAKATSUGU OKEGAWA More articles by this author KIKUO NUTAHARA More ...
Tópico(s): CAR-T cell therapy research
2005 - Lippincott Williams & Wilkins | The Journal of Urology
Eiji Higashihara, Kikuo Nutahara, Miho Kojima, Takatsugu Okegawa, Ichiro Miura, Akiomi Miyata, Moriaki Kato, Hajime Sugisaki, Takeshi Tomaru,
... Cancer Eiji Higashihara, Kikuo Nutahara, Miho Kojima, Takatsugu Okegawa, Ichiro Miura, Akiomi Miyata, Moriaki Kato, Hajime Sugisaki, ... Kikuo NutaharaKikuo Nutahara , Miho KojimaMiho Kojima , Takatsugu OkegawaTakatsugu Okegawa , Ichiro MiuraIchiro Miura , Akiomi MiyataAkiomi Miyata , Moriaki KatoMoriaki ... Miho Kojima More articles by this author Takatsugu Okegawa More articles by this author Ichiro Miura More ...
Tópico(s): Urologic and reproductive health conditions
1996 - Lippincott Williams & Wilkins | The Journal of Urology
Takatsugu Okegawa, Kikuo Nutahara, Eiji Higashihara,
... RECURRENCE IN PATHOLOGICAL STAGE T2 PROSTATE CANCER. Takatsugu Okegawa, Kikuo Nutahara, and Eiji Higashihara Takatsugu OkegawaTakatsugu Okegawa , Kikuo NutaharaKikuo Nutahara , and Eiji HigashiharaEiji Higashihara View ... antigenpolymerase chain reactionprostate-specific antigenbiochemical recurrenceMetricsAuthor Information Takatsugu Okegawa More articles by this author Kikuo Nutahara More ...
Tópico(s): Molecular Biology Techniques and Applications
2000 - Lippincott Williams & Wilkins | The Journal of Urology
Carolyn B. Coyne, Tauni Voelker, Susan L. Pichla, Jeffrey M. Bergelson,
... C.J. Shieh J.T. Pickles R.J. Okegawa T. Hsieh J.T. Bergelson J.M. Proc. ... C.J. Shieh J.T. Pickles R.J. Okegawa T. Hsieh J.T. Bergelson J.M. Proc. ... C.J. Shieh J.T. Pickles R.J. Okegawa T. Hsieh J.T. Bergelson J.M. Proc. ...
Tópico(s): Vector-Borne Animal Diseases
2004 - Elsevier BV | Journal of Biological Chemistry
Andrea Dörner, Dingding Xiong, Kellie Couch, Toshitaka Yajima, Kirk U. Knowlton,
... C.J. Shieh J.T. Pickles R.J. Okegawa T. Hsieh J.T. Bergelson J.M. Proc. ... C.J. Shieh J.T. Pickles R.J. Okegawa T. Hsieh J.T. Bergelson J.M. Proc. ...
Tópico(s): CAR-T cell therapy research
2004 - Elsevier BV | Journal of Biological Chemistry
K. Ichikawa, Katsunori Tanaka, Hiroyuki Kamiya,
Tokyu Dwell Okegawa adopted the idea of Woonerf in the design of passages at housing developments to improve the living environment ... introduces the actual condition of management and operation. Okegawa Village planning is evaluated by results of questionnaires ...
Tópico(s): Urban and spatial planning
1984 - Elsevier BV | IATSS Research
Motohatsu Fujiwara, Chikako Tanaka, Takashi Honjo, Tadao Okegawa,
The localization of tissue noradrenaline in rat salivary glands has been studied by a fluorescence method for histochemical demonstration of catecholamines in combination with a pharmacological approach.In the submaxillary gland, noradrenaline fluorescence showed a fine network surrounding the secretory acini and the granular tubules, but there was no fluorescence in their cell bodies. The walls of arteries and arterioles were also surrounded by noradrenaline fluorescence but the intra- and interlobular ...
Tópico(s): Stress Responses and Cortisol
1965 - Japanese Pharmacological Society | The Japanese Journal of Pharmacology
Motohatsu Fujiwara, Chikako Tanaka, H Hikosaka, Tadao Okegawa,
The cytological localization of noradrenaline, monoamine oxidase and acetylcholinesterase was examined in the salivary glands of the dog. The noradrenaline-fluorescent nerve fibers surrounded the secretory acini of the submaxillary, sublingual and parotid glands, but the density in the sublingual gland was much less than in the other two glands. Noradrenaline fluorescence was not seen in the cytoplasms of the acinar cells nor in the vicinity of the excretory ducts. Intense fluorescence was present ...
Tópico(s): Biotin and Related Studies
1966 - SAGE Publishing | Journal of Histochemistry & Cytochemistry
YASUHISA SAIKI, KUNIO MORINAGA, OSAMU OKEGAWA, SACHIKO SAKAI, YOSHIMASA AMAYA, Akira Ueno, SEIGO FUKUSHIMA,
The chemical components of Japanese Baizhi (Byakushi), the root of Angelica dahurica BENTH. et HOOK. (Umbelliferae), were investigated. As coumarin components, xanthotoxin, marmesin, scopoletin, anhydrobyakangelicin (isobyakangelicol), and neobyakangelicol (I) were newly isolated, in addition to byakangelicol, byakangelicin, phellopterin, oxypeucedanin, and imperatorin reported previously. The structure of I was elucidated as 5-methoxy-8-(2'-hydroxy-3'-methyl-buten-3'-yl) oxypsoralen from the following ...
Tópico(s): Synthesis of Organic Compounds
1971 - Pharmaceutical Society of Japan | YAKUGAKU ZASSHI
Toshimichi Tsuboi, Buichi Fujitani, J. Maeda, Kōji Yoshida, M Shimizu, A Kawasaki, T Okegawa, M Tsuboshima,
OP 1206, 17(S)-methyl-ω-homo-trans-Δ2-prostaglandin E1, inhibited guinea-pig platelet aggregation induced by ADP, collagen, A 23187, arachidonic acid, labile aggregation stimulating substances (LASS) and thromboxane A2 (TXA2)-like substance, and platelet adhesiveness to a glass bead column. The potency of inhibition was 10–16 times stronger than that of prostaglandin E1 (PGE1). ADP-induced platelet aggregation was notably disaggregated by the addition of OP 1206 after induction of aggregation. The ...
Tópico(s): Analytical Methods in Pharmaceuticals
1980 - Elsevier BV | Thrombosis Research
Katsuhiro Imaki, Shigeru Sakuyama, Takanori Okada, Masaaki Toda, Masaki Hayashi, Tsumoru Miyamoto, Akiyoshi Kawasaki, Tadao Okegawa,
1-[3-Mercaptoalkanoyl] pyroglutamic acids and 1-[3-mercaptoalkanoyl]-4-hetero (oxa, thia and aza) pyroglutamic acids were prepared and their inhibitory activities against angiotensin-converting enzyme (ACE) were examined. (2S)-1-[(2S)-3-Mercapto-2-methylpropanoyl] pyroglutamic acid 2 was found to be the most potent orally active inhibitor of ACE of rabbit lung among the derivatives synthesized in the present study and appeared to have great potential for use as an oral antihypertensive agent.
Tópico(s): Chemical Reaction Mechanisms
1981 - Pharmaceutical Society of Japan | Chemical and Pharmaceutical Bulletin
T Okegawa, Phyllis Jonas, Katherine DeSchryver, A Kawasaki, Philip Needleman,
Unilateral ureter obstruction in rabbits produced profound changes in endogenous and exogenous renal arachidonic acid metabolism. Isolated perfused hydronephrotic kidneys (removed after 3 or 10 d of ureter obstruction) responded to bradykinin stimulation with a markedly enhanced release of prostaglandin E2 and thromboxane A2. Reversal (3 or 10 d) of the ureter obstruction resulted in a reduction in the vasoactive peptide-induced release of prostaglandin E2 and thromboxane A2 from the perfused hydronephrotic ...
Tópico(s): Pharmacogenetics and Drug Metabolism
1983 - American Society for Clinical Investigation | Journal of Clinical Investigation
J B Lefkowith, Tadao Okegawa, K DeSchryver-Kecskemeti, Philip Needleman,
Unilateral ureteral obstruction in rabbits leads to an influx of macrophages into the kidney, a proliferation of interstitial cells, and an increase in arachidonic acid metabolism. The role of the macrophage in the metabolic changes of hydronephrosis was investigated by using endotoxin and nitrogen mustard. The in vivo administration of endotoxin, a macrophage agonist, 1 hour before perfusion of the hydronephrotic kidney markedly enhanced (fourfold to tenfold) the peptide-stimulated arachidonic acid ...
Tópico(s): Fatty Acid Research and Health
1984 - Elsevier BV | Kidney International
Hidetada Komatsu, Yasuo Takehana, Shinji Kikuchi, Masami Kojima, Shuichiro Hamano, Hiroshi Kusama, Tadao Okegawa, Shigeru Ikeda,
We studied the effect of (E)-3-[p-(1H-imidazol-1-ylmethyl)phenyl]-2-propenoic acid hydrochloride monohydrate (OKY-046.HCl), a specific thromboxane (TX) A2 synthetase inhibitor, on airway hyperresponsiveness of guinea pigs. OKY-046.HCl (30-100 mg/kg, intraduodenally (i.d.) or orally (p.o.)) suppressed dose dependently the airway hyperresponsiveness to acetylcholine (ACh) induced by formyl-methionyl-leucyl-phenylalanine (FMLP), platelet activating factor (PAF) and repetitive antigen. OKY-046.HCl (100 mg/kg) ...
Tópico(s): Mast cells and histamine
1990 - Elsevier BV | European Journal of Pharmacology
Seiji Hiraku, Ken Taniguchi, Korekiyo Wakitani, Nagashige Omawari, Heizo KtRA, Tsumoru Miyamoto, Tadao Okegawa, A Kawasaki, Arao Ujiie,
The effects of (E)-3-[p-(1H-imidazol-1-ylmethyl)phenyl]-2-propenoic acid (OKY-046) on thromboxane A2 (TXA2) synthetase in vitro and on experimental animal models of sudden death and cerebral infarction were studied. IC50 values of OKY-046 for the TXA2 synthetase of human, rabbit, dog and guinea pig washed platelets were 0.004. 0.004. 0.26 and 2.4 μM. respectively. OKY-046 at concentrations up to 1 mM. however, did not inhibit prostacyclin (PGI2) synthetase from bovine aorta microsomes or cyclooxygenase ...
Tópico(s): Eicosanoids and Hypertension Pharmacology
1986 - Japanese Pharmacological Society | The Japanese Journal of Pharmacology
Yoshinobu Masuda, Y Ochi, Yoshiaki Ochi, Tadahiko Karasawa, Naonobu Hatano, Toshiaki Kadokawa, Tadao Okegawa,
Protective effects of OP-2507 [15-cis-(4-propylcyclohexyl)-16,17,18,19,20-pentanor-9-deoxy -9 alpha, 6-nitrilo-PGF1 methyl ester] against cerebral anoxia and edema were investigated in a variety of experimental models in mice and rats. OP-2507 given s.c. or p.o. led to a consistent and dose-dependent prolongation of survival time against cerebral anoxia in hypobaric and normobaric hypoxia, KCN-induced anoxia and decapitation-induced gasping. Furthermore, treatment with 0.03-0.1 mg/kg s.c. or 0.3 mg/ ...
Tópico(s): High Altitude and Hypoxia
1986 - Elsevier BV | European Journal of Pharmacology
Kigen Kondo, Rumi Seo, Masao Naka, Toshikazu Kitagawa, Korekiyo Wakitani, Moriyuki Sakata, Heizo Kira, Tadao Okegawa, Akiyoshi Kawasaki,
The beneficial effects of an antagonist of the thromboxane A2/prostaglandin endoperoxide receptor, 7-[2α,4α-(dimethylmethano)-6β-(2-cyclopentyl-2β-hydroxyacetamido)-1α-cyclohexyl]-5(Z)-heptenoic acid (ONO-3708) on thrombosis were examined. ONO-3708 at 0.1–3 μM inhibited the human platelet aggregation induced by thromboxane A2, prostaglandin H2, collagen, ADP (secondary phase) and epinephrine (secondary phase) without affecting prostanoid synthesis and the content of cyclic AMP in platelets. The in ...
Tópico(s): Eicosanoids and Hypertension Pharmacology
1989 - Elsevier BV | European Journal of Pharmacology
Tamiya Terawaki, Toshio Takakuwa, Sadahiko Iguchi, Korekiyo Wakitani, Heizo Kira, Tadao Okegawa, Akiyoshi Kawasaki, Yoshinobu Masuda,
We evaluated the inhibitory activity of a novel prostacyclin analog, OP-2507 (15-cis-(4-n-propylcyclohexyl)-16,17,18,19,20-pentanor-9-deo xy-6,9 alpha- nitriloprostaglandin F1 methyl ester) on the brain edema induced by occlusion of the middle cerebral artery in cats. Middle cerebral artery occlusion for 4h caused a decrease of regional cerebral blood flow. The specific gravity of the cerebral cortex measured 4h after the middle cerebral artery occlusion as an index of cerebral edema showed a significant ...
Tópico(s): Acute Ischemic Stroke Management
1988 - Elsevier BV | European Journal of Pharmacology
Takatsugu Okegawa, Kikuo Nutahara, Eiji Higashihara,
Using the CellSearch System we evaluated whether circulating tumor cells predict survival in patients with hormone refractory prostate cancer.Circulating tumor cells were counted with the CellSearch System in whole blood. This system was developed using epithelial cell adhesion prostate cancer antibody based, immunomagnetic capture and automated staining methodology. Blood samples from 64 patients with hormone refractory prostate cancer were analyzed.A threshold of 5 or more circulating tumor cells ...
Tópico(s): Cancer Genomics and Diagnostics
2009 - Lippincott Williams & Wilkins | The Journal of Urology
... Feb-1997.Higashihara E, Nutahara K, Kojima M, Okegawa T, Miura I, Miyata A, Kato M, Sugisaki ...
Tópico(s): Urologic and reproductive health conditions
1991 - Lippincott Williams & Wilkins | The Journal of Urology
Avi Stein, Jean B. deKernion, Robert B. Smith, Frederick J. Dorey, Hetal Patel,
... 101-105), Online publication date: 1-Jul-2000.Okegawa T, Nutahara K and Higashihara E (2018) DETECTION ...
Tópico(s): Urologic and reproductive health conditions
1992 - Lippincott Williams & Wilkins | The Journal of Urology
Fernand Labrie, André Dupont, Raul Suburu, Léonello Cusan, Marjolaine Tremblay, José‐Luis Gomez, Jean Emond,
... Jun-1997.Higashihara E, Nutahara K, Kojima M, Okegawa T, Miura I, Miyata A, Kato M, Sugisaki ...
Tópico(s): Molecular Biology Techniques and Applications
1992 - Lippincott Williams & Wilkins | The Journal of Urology
Ove Gustafsson, Ulf Norming, Lars-Erik Almgård, A Fredriksson, Göran Gustavsson, Bengt Harvig, Claes R. Nyman,
... May-2003.Higashihara E, Nutahara K, Kojima M, Okegawa T, Miura I, Miyata A, Kato M, Sugisaki ...
Tópico(s): Molecular Biology Techniques and Applications
1992 - Lippincott Williams & Wilkins | The Journal of Urology
Hitoshi Maegawa, Nobuo Katsube, Tadao Okegawa, Hideki Aishita, Akiyoshi Kawasaki,
Tópico(s): Memory and Neural Mechanisms
1992 - Elsevier BV | Life Sciences
Takatsugu Okegawa, YINGMING LI, Rey-Chen Pong, Jer‐Tsong Hsieh,
Tópico(s): Cellular Mechanics and Interactions
2002 - Lippincott Williams & Wilkins | The Journal of Urology
... 41-49), Online publication date: 1-Feb-2007. OKEGAWA T, ODAGANE A, NUTAHARA K and HIGASHIHARA E ( ...
Tópico(s): Urological Disorders and Treatments
2002 - Lippincott Williams & Wilkins | The Journal of Urology