Nils Eiel Steen, Zillur Rahman, Attila Szabó, Guy Hindley, Nadine Parker, Weiqiu Cheng, Aihua Lin, Kevin S. O’Connell, Mashhood Ahmed Sheikh, Alexey Shadrin, Shahram Bahrami, Sandeep Karthikeyan, E. Hoseth, Anders M. Dale, Pål Aukrust, Olav B. Smeland, Thor Ueland, Oleksandr Frei, Srdjan Djurovic, Ole A. Andreassen,
Immune mechanisms are indicated in schizophrenia (SCZ). Recent genome-wide association studies (GWAS) have identified genetic variants associated with SCZ and immune-related phenotypes. Here, we use cutting edge statistical tools to identify shared genetic variants between SCZ and white blood cell (WBC) counts and further understand the role of the immune system in SCZ.GWAS results from SCZ (patients, n = 53 386; controls, n = 77 258) and WBC counts (n = 56 3085) were analyzed. We applied linkage disequilibrium ...
Tópico(s): Immune Cell Function and Interaction
2023 - Oxford University Press | Schizophrenia Bulletin
Thor Ueland, Lars Erik Laugsand, Lars J. Vatten, Imre Janszky, Carl Platou, Annika E. Michelsen, Jan Kristian Damås, Pål Aukrust, Bjørn Olav Åsvold,
Extracellular matrix remodelling may influence atherosclerotic progression and plaque stability. We hypothesized that evaluation of extracellular matrix markers, with potentially different roles during atherogenesis, could provide information on underlying mechanisms and risk of myocardial infarction (MI) in apparently healthy individuals. We conducted a case–control study nested within the population-based HUNT2 cohort in Norway. A total of 58,761 men and women, free of known cardiovascular disease, ...
Tópico(s): Studies on Chitinases and Chitosanases
2017 - Oxford University Press | European Journal of Preventive Cardiology
May‐Kristin Torp, Kuan Yang, Trine Ranheim, Knut H. Lauritzen, Katrine Alfsnes, Leif Erik Vinge, Pål Aukrust, Kåre‐Olav Stensløkken, Arne Yndestad, Øystein Sandanger,
Background: IL-1β is a highly potent pro-inflammatory cytokine and its secretion is tightly regulated. Inactive pro-IL-1β is transcribed in response to innate immune receptors activating NFκB. If tissue damage occurs, danger signals released from necrotic cells, such as ATP, can activate NLRP3-inflammasomes (multiprotein complexes consisting of NLRP3, ASC, and active caspase-1) which cleaves and activates pro-IL-1β. NLRP3 activation also depends on NEK7 and mitochondrial ROS-production. Thus, IL- ...
Tópico(s): Peptidase Inhibition and Analysis
2019 - Frontiers Media | Frontiers in Immunology
Marianne Nome, Leslie R. Euceda, Shakila Jabeen, Julia Debik, Tone F. Bathen, Guro F. Giskeødegård, Kristin Austlid Taskén, Gunhild M. Mælandsmo, Bente Halvorsen, Arne Yndestad, Elin Borgen, Øystein Garred, Pål Aukrust, Thor Ueland, Olav Engebraaten, Vessela N. Kristensen, Xavier Tekpli,
Angiogenesis is necessary for tumor growth and has been targeted in breast cancer; however, it is unclear which patients will respond and benefit from antiangiogenic therapy. We report noninvasive monitoring of patient response to neoadjuvant chemotherapy given alone or in combination with anti-vascular endothelial growth factor (bevacizumab) in a randomized clinical trial. At four time points during neoadjuvant chemotherapy ± bevacizumab of receptor tyrosine-protein kinase erbB-2-negative breast cancers, ...
Tópico(s): Cancer, Lipids, and Metabolism
2019 - Wiley | International Journal of Cancer
Tonje Skarpengland, Lars Erik Laugsand, Imre Janszky, Luisa Luna, Bente Halvorsen, Carl Platou, Wei Wang, Lars J. Vatten, Jan Kristian Damås, Pål Aukrust, Magnar Bjørås, Bjørn Olav Åsvold,
Enhanced generation of reactive oxygen species and increased oxidative-induced DNA damage have been identified as possible contributors to atherosclerosis. The base excision repair (BER) pathway is the principal mechanism by which mammalian cells repair oxidative DNA damage. BER deficiency can potentially accelerate atherogenesis. We evaluated the association of Single Nucleotide Polymorphisms (SNPs) in genes encoding four different BER proteins (NEIL3, OGG1, APEX1 and XRCC1) with the incidence of ...
Tópico(s): RNA regulation and disease
2015 - Elsevier BV | DNA repair
Pål Aukrust, Jan Kristian Damås, Nils Olav Solum,
Platelet adhesion and aggregation at the site of plaque rupture is a crucial event in thrombus formation and the development of acute coronary syndrome (ACS). However, recent studies suggest that platelets also may trigger ACS through other mechanisms such as the stimulation of an inflammatory
Tópico(s): Antiplatelet Therapy and Cardiovascular Diseases
2004 - Elsevier BV | Journal of the American College of Cardiology
Kari Otterdal, Camilla Smith, Erik Øie, Turid M. Pedersen, Arne Yndestad, Espen Stang, Knut Endresen, Nils Olav Solum, Pål Aukrust, J Damås,
Tópico(s): Inflammatory Biomarkers in Disease Prognosis
2006 - Elsevier BV | Blood
Torgun Wæhre, Jan Kristian Damås, Turid M. Pedersen, Lars Gullestad, Arne Yndestad, Arne K. Andreassen, Stig S. Frøland, Anne Grete Semb, V. H. Hansteen, Erik Gjertsen, Thor Ueland, Frank Brosstad, Nils Olav Solum, Pål Aukrust,
Chemokines and platelet activation are both important in atherogenesis. Platelet inhibitors are widely used in coronary artery disease (CAD), and we hypothesized that the platelet inhibitor clopidogrel could modify chemokines in CAD patients.We sought to investigate the effect of clopidogrel on the expression of chemokines and chemokine receptors in peripheral blood mononuclear cells (PBMC) in CAD patients.Thirty-seven patients with stable angina were randomized to clopidogrel (n = 18) or placebo (n = 19). ...
Tópico(s): Chemokine receptors and signaling
2006 - Elsevier BV | Journal of Thrombosis and Haemostasis
Torgun Wæhre, J Damås, Arne Yndestad, Kjetil Taskén, Turid M. Pedersen, Camilla Smith, Bente Halvorsen, Stig S. Frøland, Nils Olav Solum, Pål Aukrust,
Summary Platelets may act as inflammatory cells. To study the effects of soluble and cell-bound platelet factors on the expression of several cytokines and related mediators in leukocytes, peripheral blood mononuclear cells (PBMC) were incubated with platelet-free supernatants from SFLLRN-activated platelet-rich plasma (PRP) or SFLLRN-activated PRP in itself. Our main findings were: (i) the gene expression of several chemokines and some cytokines were markedly increased by both activated PRP and supernatants, ...
Tópico(s): Heparin-Induced Thrombocytopenia and Thrombosis
2004 - Thieme Medical Publishers (Germany) | Thrombosis and Haemostasis
Øystein Sandanger, Liv Ryan, Janne Ø. Bohnhorst, Ann‐Charlotte Iversen, Harald Husebye, Øyvind Halaas, Linn Landrø, Pål Aukrust, Stig S. Frøland, Greg Elson, Alberto Visintin, Olav Øktedalen, Jan Kristian Damås, Anders Sundan, Douglas T. Golenbock, Terje Espevik,
Abstract Soluble proteins that bind LPS, like myeloid differentiation-2 (MD-2) and CD14, have essential roles in regulating LPS signaling through TLR4. During a Gram-negative bacterial infection, the host may control the response by adjusting the levels of soluble MD-2 and CD14. To address the surface expression of MD-2 on human leukocytes, we developed a mAb, IIC1, that recognized MD-2 both free and when bound to TLR4. MD-2 was found on the surface of freshly isolated monocytes, on a subpopulation ...
Tópico(s): Immune Cell Function and Interaction
2009 - American Association of Immunologists | The Journal of Immunology
Ben Brumpton, Lars G. Fritsche, Jie Zheng, Jonas B. Nielsen, Maria Mannila, Ida Surakka, Humaira Rasheed, Gunnhild Åberge Vie, Sarah E. Graham, Maiken E. Gabrielsen, Lars Erik Laugsand, Pål Aukrust, Lars J. Vatten, Jan Kristian Damås, Thor Ueland, Imre Janszky, John‐Anker Zwart, Ferdinand M. van’t Hooft, Nabil G. Seidah, Kristian Hveem, Cristen J. Willer, George Davey Smith, Bjørn Olav Åsvold,
... Trondheim. Department of Cardiology (L.E.L.), St. Olavs Hospital, Trondheim University Hospital, Norway. , Pål AukrustPål Aukrust Research Institute of Internal Medicine (P.A., T. ...
Tópico(s): Atherosclerosis and Cardiovascular Diseases
2019 - Wolters Kluwer | Circulation Genomic and Precision Medicine
Nadine Parker, Weiqiu Cheng, Guy Hindley, Kevin S. O’Connell, Sandeep Karthikeyan, Børge Holen, Alexey Shadrin, Zillur Rahman, Naz Karadag, Shahram Bahrami, Aihua Lin, Nils Eiel Steen, Thor Ueland, Pål Aukrust, Srdjan Djurovic, Anders M. Dale, Olav B. Smeland, Oleksandr Frei, Ole A. Andreassen,
For many brain disorders, a subset of patients jointly exhibit alterations in cortical brain structure and elevated levels of circulating immune markers. This may be driven in part by shared genetic architecture. Therefore, we investigated the phenotypic and genetic associations linking global cortical surface area and thickness with blood immune markers (i.e., white blood cell counts and plasma C-reactive protein levels).Linear regression was used to assess phenotypic associations in 30,823 UK Biobank ...
Tópico(s): Neuroinflammation and Neurodegeneration Mechanisms
2023 - Elsevier BV | Biological Psychiatry
Thor Ueland, Lars Erik Laugsand, Lars J. Vatten, Imre Janszky, Carl G. P. Platou, Annika E. Michelsen, Jan Kristian Damås, Pål Aukrust, Bjørn Olav Åsvold,
We hypothesized that circulating markers reflecting monocyte/macrophage and T cell activation are associated with increased risk of myocardial infarction (MI) in apparently healthy individuals. Serum monocyte/macrophage and T cell activation markers soluble (s) CD163, sCD14, Gal3BP, sCD25 and sCD166 were analyzed by enzyme-immunoassay in a case-control study nested within the population-based HUNT2 cohort in Norway. Among 58,761 apparently healthy men and women followed a median 11.3 years, 1587 incident ...
Tópico(s): Adipokines, Inflammation, and Metabolic Diseases
2017 - Elsevier BV | International Journal of Cardiology
B. Tirkkonen, A. Aukrust, E. Couture, David Grace, Y. Haile, Kerstin Holm, H. Hope, Alf Olav Larsen, H. Sivertsen Lunde, Carl E. Sjøgren,
To determine the structure and various physicochemical properties of mangafodipir (MnDPDP) trisodium, the active ingredient of Teslascan, a new-organ-specific contrast medium for MR imaging.The structure of MnDPDP trisodium crystals was determined by X-ray crystallography. The possible existence of polymorphism in MnDPDP trisodium was evaluated by powder X-ray diffraction, optical microscopy, thermal analysis and IR spectroscopy. In addition, various spectroscopic techniques and physicochemical measurements ...
Tópico(s): Advanced MRI Techniques and Applications
1997 - SAGE Publishing | Acta Radiologica
Pål Aukrust, Fredrik Müller, Thor Ueland, Trude Berget, E. Aaser, Anne Brunsvig, Nils Olav Solum, Kolbjørn Forfang, Stig S. Frøland, Lars Gullestad,
Background —The CD40 ligand (CD40L) on activated T cells and platelets may be activating matrix metalloproteinases, inducing procoagulant activity, and be involved in the pathogenesis of acute coronary syndromes by promoting plaque rupture in atheroma. Methods and Results —To study the role of CD40L-CD40 interaction in coronary disease, we analyzed levels of soluble (s) and membrane-bound CD40L in the peripheral blood from 29 patients with stable angina, 26 with unstable angina, and 19 controls. Our ...
Tópico(s): T-cell and B-cell Immunology
1999 - Lippincott Williams & Wilkins | Circulation
Nils Olav Solum, Thor Ueland, Vibeke Videm, Pål Aukrust, Jan Roar Mellembakken,
Activated platelets may release inflammatory mediators that activate leukocytes and trigger inflammatory reactions in endothelial cells. We examined the concentrations of soluble CD40 ligand (sCD40L) and the chemokines RANTES and GRO-alpha in platelet-free plasma (PFP), and unstimulated and SFLLRN-stimulated platelet-rich plasma (PRP), as well as in platelet pellets before stimulation using enzyme immunoassays. Nineteen women with normal and twenty-one with preeclamptic pregnancies were studied, and ...
Tópico(s): MicroRNA in disease regulation
2001 - Thieme Medical Publishers (Germany) | Thrombosis and Haemostasis
Morten Bækken, Ingjerd W. Manner, Thor Ueland, Stig S. Frøland, Ingrid Os, Pål Aukrust, Olav Øktedalen, J Damås,
... Frøland, MD, PhD§ Ingrid Os, MD, PhD∥ Pål Aukrust, MD, PhD¶ Olav Øktedalen, MD, PhD** Jan K. Damås, MD, PhD†† * ...
Tópico(s): HIV Research and Treatment
2010 - Lippincott Williams & Wilkins | JAIDS Journal of Acquired Immune Deficiency Syndromes
Jan Kristian Damås, Torgun Wæhre, Arne Yndestad, Kari Otterdal, Aina Hognestad, Nils Olav Solum, Lars Gullestad, Stig S. Frøland, Pål Aukrust,
Background— Atherogenesis and plaque destabilization involve immune-mediated mechanisms, but the actual mediators have not been fully clarified. Interleukin (IL)-7 is a regulator of T-cell homeostasis but also may be involved in inflammation. We hypothesized that IL-7 could be involved in the inflammatory processes observed in atherosclerosis and acute coronary syndromes. Methods and Results— To study the role of IL-7 in coronary artery disease, we analyzed IL-7 levels and the effect of this cytokine ...
Tópico(s): Chemokine receptors and signaling
2003 - Lippincott Williams & Wilkins | Circulation
Produção Nacional
Revisado por pares
T. Holm, J Damås, Kirsten B. Holven, Ingvild Nordøy, Frank Brosstad, Thor Ueland, T. Währe, John Kjekshus, Stig S. Frøland, Hans Geir Eiken, Nils Olav Solum, Lars Gullestad, Marit S. Nenseter, Pål Aukrust,
SummaryCXC-chemokines may be involved in atherogenesis. Herein we examined the possible role of CXC-chemokines in the inflammatory interactions between oxidized (ox-) low-density lipoprotein (LDL), platelets and peripheral blood mononuclear cells (PBMC) in 15 patients with coronary artery disease (CAD) without ‘traditional’ risk factors and 15 carefully matched controls. Our main findings were: (a) ox-LDL stimulated the release of the CXC-chemokines interleukin (IL)-8, ENA-78 and GRO-α from PBMC, particularly ...
Tópico(s): Adipokines, Inflammation, and Metabolic Diseases
2003 - Elsevier BV | Journal of Thrombosis and Haemostasis
J Damås, Kari Otterdal, Arne Yndestad, Halfdan Aass, Nils Olav Solum, Stig S. Frøland, Svein Simonsen, Pål Aukrust, Arne K. Andreassen,
Inflammatory processes seem to be involved in pulmonary arterial hypertension (PAH). CD40 ligand (L) may promote inflammation and thrombus formation, and we hypothesized that CD40L could be involved in the pathogenesis of PAH.Several significant findings were revealed when examining the possible role of CD40L in PAH. (1) Patients with primary (n=13) and secondary (n=11) PAH but not those with chronic thromboembolic pulmonary hypertension (n=8) had increased plasma levels of soluble (s) CD40L compared with ...
Tópico(s): Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
2004 - Lippincott Williams & Wilkins | Circulation
Pål André Holme, Fredrik Müller, Nils Olav Solum, Frank Brosstad, Stig S. Frøland, Pål Aukrust,
Besides their role in hemostasis, platelets are involved in inflammatory and immunological processes, and we hypothesize that platelet activation may play an immunopathogenetic role in HIV-1 infection. Blood was drawn from 15 controls and 20 HIV-1-infected patients with normal platelet counts, classified into groups of non-AIDS and AIDS. Platelet activation was detected using flow cytometry with mAbs against the release markers P-selectin and CD63, mAb against GPIb, and the probe annexin V detecting ...
Tópico(s): HIV Research and Treatment
1998 - Wiley | The FASEB Journal
Pål André Holme, Fredrik Müller, Nils Olav Solum, Frank Brosstad, Stig S. Frøland, Pål Aukrust,
Besides their role in hemostasis, platelets are involved in inflammatory and immunological processes, and we hypothezise that platelet activation may play an immunopathogenetic role in HIV-1 infection. Blood was drawn from 15 controls and 20 HIv-1-infected patients with normal platelet counts, classified into groups of non-AIDS and AIDS. Platelet activation was detected using flow cytometry with mAbs against the release markers P-selectin and CD63, mAb against GPIb, and the probe annexin V detecting ...
Tópico(s): HIV Research and Treatment
1998 - Wiley | The FASEB Journal
Pål Aukrust, Stine Bjørnsen, B Lunden, Kari Otterdal, Ermakova Ng, W. Ameln, Thor Ueland, Fredrik Müller, Nils Olav Solum, Frank Brosstad, Stig S. Frøland,
Summary Levels of circulating von Willebrand factor (vWf) antigen are thought to reflect endothelial involvement in various disorders. In the present study we found markedly elevated plasma levels of vWf in HIV-infected patients demonstrated on both cross-sectional and longitudinal testing. Notably, we found that a persistent rise in vWf antigen was associated with progression of HIV-related disease. This elevation of vWf antigen represented functionally normal vWf as evaluated by plasma FVIII, ristocetin ...
Tópico(s): Parvovirus B19 Infection Studies
2000 - Thieme Medical Publishers (Germany) | Thrombosis and Haemostasis
Bjørn Waagsbø, Asbjørn Svardal, Thor Ueland, Linn Landrø, Olav Øktedalen, Rolf K. Berge, Trude H. Flo, Pål Aukrust, Jan Kristian Damås,
Abstract Background Carnitine plays an essential role in fatty acid metabolism, exerts substantial antioxidant action and regulates immune functions. We hypothesized that a disturbed carnitine metabolism could be involved in progression of HIV infection. Materials and methods Plasma levels of L‐carnitine, its precursors, and short‐, medium‐ and long‐chain acylcarnitines were analysed with HPLC /mass spectrometry in HIV ‐infected patients with various disease severities including patients who acquired ...
Tópico(s): Infectious Encephalopathies and Encephalitis
2016 - Wiley | European Journal of Clinical Investigation
... dialect in four nynorsk writers from North Gudbrandsdal—Olav Aukrust, Tor Jonsson, Tore 0rjasa;ter, and Jan Magnus ...
Tópico(s): linguistics and terminology studies
1990 - Linguistic Society of America | Language
Christian Prebensen, Thor Ueland, Annika E. Michelsen, Andreas Lind, Frank Olav Pettersen, Tom Eirik Mollnes, Pål Aukrust, Anne Ma Dyrhol‐Riise, Dag Kvale,
Background: HIV-infected patients who fail to reconstitute their CD4 T-cell counts during suppressive antiretroviral therapy (ART) have increased risk of both AIDS-related and non–AIDS-related morbidity and mortality. Improved understanding of immunological nonresponse (INR) is necessary to enable earlier clinical intervention. Methods: In a cohort of 112 HIV-infected patients starting ART, we performed a serial analysis of 32 plasma-soluble markers, assessed by multiplex cytokine and enzyme immunoassay. ...
Tópico(s): HIV/AIDS drug development and treatment
2015 - Lippincott Williams & Wilkins | JAIDS Journal of Acquired Immune Deficiency Syndromes
Lars Erik Laugsand, Bjørn Olav Åsvold, Lars J. Vatten, Imre Janszky, Carl Platou, Annika E. Michelsen, Jan Kristian Damås, Pål Aukrust, Thor Ueland,
The usefulness of circulating proprotein convertase subtilisin-kexin type 9 (PCSK9) as a risk marker of coronary heart disease in the general population remains unclear. In a nested case-control study in Norway, 1,488 incident myocardial infarctions were registered during 11.3 years of follow-up and compared with 3,819 controls. Compared with participants in the lowest quartile of PCSK9, myocardial infarction risk was 47% higher in the highest quartile after adjustment for age and sex. After additional ...
Tópico(s): Cardiac Imaging and Diagnostics
2016 - Elsevier BV | JACC Basic to Translational Science
Lars Erik Laugsand, Bjørn Olav Åsvold, Lars J. Vatten, Imre Janszky, Carl Platou, Annika E. Michelsen, Fizza Arain, Jan Kristian Damås, Pål Aukrust, Thor Ueland,
Background and aims CXCL16 is an interferon-γ-regulated chemokine and scavenger receptor for oxidized low-density lipoprotein that is expressed in atherosclerotic lesions. High soluble CXCL16 levels during acute cardiovascular events may indicate impaired long-term prognosis, but it is not known if CXCL16 is associated with the risk of developing cardiovascular disease in healthy individuals. We aimed to assess whether soluble CXCL16 is associated with risk of myocardial infarction (MI) in a nested ...
Tópico(s): Cytokine Signaling Pathways and Interactions
2015 - Elsevier BV | Atherosclerosis
Jan Kristian Damås, Morten Bækken, Thor Ueland, Ingjerd W. Manner, Ingrid Os, Arne Yndestad, Trude H. Flo, Olav Øktedalen, Pål Aukrust,
To the Editors: With improved survival after the introduction of antiretroviral therapy (ART), cardiovascular and hepatic diseases represent an increasing burden for HIV-infected individuals.1 Renal diseases have also emerged as significant causes of morbidity and mortality in these patients.1 HIV-associated nephropathy has been the most common cause of renal failure in HIV-infected persons of African descent who are not receiving ART. However, other causes of kidney disease related to ART, its metabolic ...
Tópico(s): Muscle and Compartmental Disorders
2012 - Lippincott Williams & Wilkins | JAIDS Journal of Acquired Immune Deficiency Syndromes
Trine Kåsine, Anne Ma Dyrhol‐Riise, Andreas Barratt‐Due, Anders Benjamin Kildal, Inge Christoffer Olsen, Kateřina Nezvalová‐Henriksen, Fridtjof Lund‐Johansen, Hedda Hoel, Aleksander Rygh Holten, Anders Tveita, Alexander Mathiessen, Mette Haugli, Ragnhild Eiken, Åse Berg, Asgeir Johannessen, Lars Heggelund, Tuva B. Dahl, Bente Halvorsen, Paweł Mielnik, Lan Ai Kieu Le, Lars Thoresen, Gernot Ernst, Dag Arne Lihaug Hoff, Hilde Skudal, Bård Reiakvam Kittang, Roy Bjørkholt Olsen, Birgitte Tholin, Carl Magnus Ystrøm, Nina Vibeche Skei, Raisa Hannula, Olav Dalgård, Ane‐Kristine Finbråten, Kristian Tonby, Saad Aballi, Fredrik Müller, Kristin Greve‐Isdahl Mohn, Marius Trøseid, Pål Aukrust, Thor Ueland,
To the Editor: Despite numerous studies on SARS-CoV-2-induced inflammation, we still lack markers for rapid disease progression with admission to intensive care unit (ICU) or respiratory failure (RF). Few studies have evaluated the prognostic value of routine diagnostic repertoire available at most hospitals. The NOR-Solidarity trial is an independent add-on study to the WHO Solidarity trial, evaluating hydroxychloroquine (HCQ) and remdesivir compared to standard of care in hospitalized COVID-19 patients [ ...
Tópico(s): Sepsis Diagnosis and Treatment
2021 - Wiley | Journal of Internal Medicine