Anders Andrae, Mikko Samuli Vaija,
... the simplified LCA method (Open Eco Rating LCA, OLCA) used by the open eco rating (OER) sustainability assessment. OLCA is described in detail. The comparisons use the ... that the difference between the FLCAs and the OLCA is up to 20% for the Global Warming ... significantly different emission intensities used in FLCAs and OLCA, especially for integrated circuit and screen production. The ... the FLCAs of mobile phones, and used in OLCA and compared with the corresponding FLCA ARDI score. ... vs. 3.76 grams Sb—eq.) higher than OLCA ARDI for the mobile phone and the tablet, ...
Tópico(s): Sustainable Supply Chain Management
2017 - Multidisciplinary Digital Publishing Institute | Challenges
... strategy, namely the Opposition-based Learning Cooking Algorithm (OLCA). The proposed OLCA algorithm consists of four stages: the first stage, ... applied again to update the population. The proposed OLCA has been examined over 23 test functions, and the OLCA outcomes are equated with several popular and top- ... see text]-test, reveal that the outcomes of OLCA may effectively address optimization problems by maintaining a ... balance between exploitation and exploration. Furthermore, the proposed OLCA has been employed to solve three real-world ...
Tópico(s): Metaheuristic Optimization Algorithms Research
2023 - World Scientific | International Journal of Modern Physics C
Fuqing Zhao, Bo Zhu, Ling Wang, Tianpeng Xu, Ningning Zhu, Jonrinaldi Jonrinaldi,
... corresponding problems. An offline learning co-evolutionary algorithm (OLCA) based on the fitness landscape analysis that introduces ... the beginning of the evolutionary process. The proposed OLCA is tested by using the CEC 2017 benchmark ... art algorithms. The results show that the proposed OLCA is efficient and competitive for solving complex continuous ... problems. In addition, the effectiveness of the proposed OLCA is also verified by using 19 IEEE CEC ...
Tópico(s): Evolutionary Algorithms and Applications
2022 - Elsevier BV | Swarm and Evolutionary Computation
Alexander Cremer, Markus Berger, Katrin Müller, Matthias Finkbeiner,
... major contributor to environmental pressures. Recently, organizational LCA (OLCA) has been found to align well with requirements ... scale environmental decision support and a novel city-OLCA framework was introduced. City-OLCA combines two relevant aspects: It covers activities beyond ... goal of this work is to test city-OLCA’s feasibility in a first case study with ...
Tópico(s): Sustainable Building Design and Assessment
2021 - Multidisciplinary Digital Publishing Institute | Sustainability
Clarisa Marotte, Gabriel Bryk, M.M.S. Gonzáles Chaves, Fima Lifshitz, María Luz Pita Martín de Portela, S.N. Zeni,
... 5 % (N) or 0.2 % (L) of Ca (OLCa, ONCa, WLCa and WNCa). Male pups were fed ... were higher, whereas body protein was lower in OLCa versus ONCa (p < 0.05). OLCa presented the highest body fat, glucose, non-HDL ... and total skeleton BMC/BW were lower in OLCa and WLCa versus their corresponding NCa groups (p < ...
Tópico(s): Diet and metabolism studies
2013 - Springer Science+Business Media | European Journal of Nutrition
Franco Tassi, Felipe Aguilera, Orlando Vaselli, Thomas H. Darrah, Eduardo Medina,
... from fumaroles and bubbling pools at Irruputuncu, Putana, Olca and Alitar volcanoes located in the central Andes ... high concentrations of magmatic gas emissions, including SO2. Olca and Alitar volcano fluid chemistries indicated lower amounts ... the present study show that the Irruputuncu, Putana, Olca and Alitar volcanoes should be considered as active ...
Tópico(s): Geology and Paleoclimatology Research
2011 - National Institute of Geophysics and Volcanology | Annals of Geophysics
Hui Mai, Jun Xia, Yongjun Wu, Junlong Ke, Junliang Li, Jiangang Pan, Wubiao Chen, Yiming Shao, Zhi Yang, Saihua Luo, Yonghua Sun, Bin Zhao, Longxuan Li,
... patients with occult lung cancer associated ischemic stroke (OLCA-stroke). A retrospective review of all ischemic stroke ... patterns on diffusion-weighted MRI in patients with OLCA-stroke, with respect to vascular territory involved, number ... and outcome of survivors. Thirteen patients with confirmed OLCA-stroke were identified. All had elevated D-dimer ...
Tópico(s): Cerebrovascular and Carotid Artery Diseases
2014 - Elsevier BV | Journal of Clinical Neuroscience
Thomas Nemecek, Assumpció Antón, Claudine Basset‐Mens, Céline Gentil‐Sergent, Christel Renaud‐Gentié, Carlos Melero, Pierre Naviaux, Nancy Peña, Philippe Roux, Peter Fantke,
... missing environmental compartments, and environmental impact pathways. The OLCA-Pest project was implemented to address these aspects ...
Tópico(s): Effects and risks of endocrine disrupting chemicals
2022 - Springer Science+Business Media | The International Journal of Life Cycle Assessment
Hendrik Marx, Silvia Forin, Matthias Finkbeiner,
... avoid burden shifting. The organizational life cycle assessment (OLCA) method was conceived and successfully tested for the ... application to service providing organizations. In this paper, OLCA was applied to a service providing SME in ...
Tópico(s): Photovoltaic Systems and Sustainability
2020 - Multidisciplinary Digital Publishing Institute | Sustainability
Roberto Cirocchi, Justus Randolph, Isaac Cheruiyot, Justin Davies, James Wheeler, Massimo Lancia, Sara Gioia, Luigi Carlini, Salomone Di Saverio, Brandon Michael Henry,
... and the origin of the left colic artery (OLCA). Results A total of 19 studies ( n = 2040 ... pooled mean distance from the OIMA to the OLCA was 40.41 mm (95 CI% 38.69– ...
Tópico(s): Colorectal Cancer Surgical Treatments
2019 - Wiley | Colorectal Disease
Alessandro Manzardo, Andrea Loss, Monia Niero, Chiara Vianello, Antonio Scipioni,
In this study, Organizational Life Cycle Assessment (OLCA) was applied to a multisite beverage company along with a product LCA to one of its representative beverage product. Results proved that, given ... it is important to use both LCA and OLCA results to effectively plan environmental performance improvement of ...
Tópico(s): Environmental Sustainability in Business
2018 - Elsevier BV | Procedia CIRP
Daqian Wu, Jian Liu, Gaosheng Zhang, Wenjuan Ding, Wei Wang, Renqing Wang,
... Lour.), CA models based on ordinary logistic regression (OLCA model) and autologistic regression (ALCA model) were developed ... minimum requirement, ALCA models showed considerable improvement upon OLCA models. Our results suggested that the incorporation of ...
Tópico(s): Remote Sensing in Agriculture
2009 - Elsevier BV | Ecological Modelling
J. Eric Schmitt, Paras Mehta, Steven H. Aggen, Thomas S. Kubarych, Michael C. Neale,
Ordered latent class analysis (OLCA) can be used to approximate unidimensional latent distributions. The main objective of this study is to evaluate the method of OLCA in detecting non-normality of an unobserved continuous ...
Tópico(s): Statistical Methods and Bayesian Inference
2006 - Taylor & Francis | Multivariate Behavioral Research
Κωνσταντίνος Ιωάννου, I. Panoutsopoulos, Stavros Koubias, Stavros Kotsopoulos,
... DCMS), using both a one-layer cellular architecture (OLCA) and a two-layer cellular architecture (TLCA), for ... The philosophy of DCMS is based either on OLCA or TLCA, and is proposed for optimisation of ...
Tópico(s): Advanced Wireless Network Optimization
2004 - Institution of Engineering and Technology | Electronics Letters
Produção Nacional
Revisado por pares
Thales Eduardo Tavares Dantas, Luis Fernando Spoladore Amaral, Sebastião Roberto Soares,
... a combined circularity and Organizational Life Cycle Assessment (OLCA) of a certified zero-waste vegan restaurant in ... restaurant was 26% higher than the reported organization). OLCA results point at the environmental benefit of following ...
Tópico(s): Environmental Sustainability in Business
2022 - Mary Ann Liebert, Inc. | Environmental Engineering Science
Zachary Sethna, Pablo Guasp, Charlotte Reiche, Martina Milighetti, Nicholas Ceglia, Erin Patterson, Jayon Lihm, George C. Payne, Olga Lyudovyk, Luis A. Rojas, Nan Pang, Akihiro Ohmoto, Masataka Amisaki, Abderezak Zebboudj, Zagaa Odgerel, Emmanuel M. Bruno, Siqi Linsey Zhang, C. K. Cheng, Yuval Elhanati, Evelyna Derhovanessian, Luisa Manning, Felicitas Müller, Ina Rhee, Mahesh Yadav, Taha Merghoub, Jedd D. Wolchok, Olca Baştürk, Mithat Gönen, Andrew S. Epstein, Parisa Momtaz, Wungki Park, Ryan Sugarman, Anna M. Varghese, Elizabeth Won, Avni M. Desai, Alice C. Wei, Michael I. D’Angelica, T. Peter Kingham, Kevin C. Soares, William R. Jarnagin, Jeffrey A. Drebin, Eileen M. O’Reilly, Ira Mellman, Uğur Şahin, Özlem Türeci, Benjamin Greenbaum, Vinod P. Balachandran,
Tópico(s): Cancer Genomics and Diagnostics
2025 - Nature Portfolio | Nature
Linda Bojmar, Constantinos P. Zambirinis, Jonathan M. Hernandez, Jayasree Chakraborty, Lee Shaashua, Junbum Kim, Kofi Ennu Johnson, Samer Hanna, Gökçe Aşkan, Jonas Burman, Hiranmayi Ravichandran, Jian Zheng, Joshua S. Jolissaint, Rami Srouji, Yi Song, Ankur P. Choubey, Han Sang Kim, Michele Cioffi, Elke van Beek, Carlie Sigel, José Jessurun, P Riestra, Hakon Blomstrand, Carolin Jönsson, Anette Bach Jønsson, Pernille Lauritzen, Weston Buehring, Yonathan Ararso, D.E Hernández, Jessica P. Vinagolu-Baur, Madison Friedman, Caroline Glidden, Laetitia Firmenich, Grace Lieberman, D. Mejia, Naaz Nasar, Anders P. Mutvei, Doru Paul, Yaron Bram, Bruno Costa‐Silva, Olca Baştürk, Nancy Boudreau, Haiying Zhang, Irina Matei, Ayuko Hoshino, David P. Kelsen, Irit Sagi, Avigdor Scherz, Ruth Scherz‐Shouval, Yosef Yarden, Moshe Oren, Mikala Egeblad, Jason S. Lewis, Kayvan R. Keshari, Paul M. Grandgenett, Michael A. Hollingsworth, Vinagolu K. Rajasekhar, John H. Healey, Bergþór Björnsson, Diane M. Simeone, David A. Tuveson, Christine A. Iacobuzio‐Donahue, Jaqueline Bromberg, C. Theresa Vincent, Eileen M. O’Reilly, Ronald P. DeMatteo, Vinod P. Balachandran, Michael I. D’Angelica, T. Peter Kingham, Peter J. Allen, Amber L. Simpson, Olivier Elemento, Per Sandström, Robert E. Schwartz, William R. Jarnagin, David Lyden,
Tópico(s): Cancer Genomics and Diagnostics
2024 - Nature Portfolio | Nature Medicine
Shubham Pant, Zev A. Wainberg, Colin D. Weekes, Muhammad Furqan, Pashtoon Murtaza Kasi, Craig Devoe, Alexis D. Leal, Vincent Chung, Olca Baştürk, Haley VanWyk, Amy Tavares, Lochana M. Seenappa, James Perry, Thian Kheoh, Lisa K. McNeil, Esther Welkowsky, Peter C. DeMuth, Christopher M. Haqq, Eileen M. O’Reilly,
Pancreatic and colorectal cancers are often KRAS mutated and are incurable when tumor DNA or protein persists or recurs after curative intent therapy. Cancer vaccine ELI-002 2P enhances lymph node delivery and immune response using amphiphile (Amph) modification of G12D and G12R mutant KRAS (mKRAS) peptides (Amph-Peptides-2P) together with CpG oligonucleotide adjuvant (Amph-CpG-7909). We treated 25 patients (20 pancreatic and five colorectal) who were positive for minimal residual mKRAS disease (ctDNA ...
Tópico(s): RNA Interference and Gene Delivery
2024 - Nature Portfolio | Nature Medicine
Laura D. Wood, Volkan Adsay, Olca Baştürk, Lodewijk A.A. Brosens, Noriyoshi Fukushima, Seung‐Mo Hong, Sung Joo Kim, Jae W. Lee, Claudio Luchini, Michaël Noë, Martha B. Pitman, Aldo Scarpa, Aatur D. Singhi, Mariko Tanaka, Toru Furukawa,
Intraductal papillary mucinous neoplasms (IPMNs) are a cystic precursor to pancreatic cancer. IPMNs deemed clinically to be at high-risk for malignant progression are frequently treated with surgical resection, and pathological examination of the pancreatectomy specimen is a key component of the clinical care of IPMN patients. Systematic literature reviews were conducted around eight topics of clinical relevance in the examination of pathological specimens in patients undergoing resection of IPMN. ...
Tópico(s): Cholangiocarcinoma and Gallbladder Cancer Studies
2023 - Elsevier BV | Pancreatology
İsmail Can Karaoğlu, Aybaran Olca Kebabci, Seda Kızılel,
Gelatin methacryloyl (GelMA) hydrogels are promising materials for tissue engineering applications due to their biocompatibility and tunable properties. However, the time-consuming process of preparing GelMA hydrogels with desirable properties for specific biomedical applications limits their clinical use. Visible-light-induced cross-linking is a well-known method for the preparation of GelMA hydrogels; however, a comprehensive investigation on the influence of critical parameters such as Eosin Y ( ...
Tópico(s): Electrospun Nanofibers in Biomedical Applications
2023 - American Chemical Society | ACS Applied Materials & Interfaces
Diana Mandelker, Antonio Marra, Nikita Mehta, Pier Selenica, Zarina Yelskaya, Ciyu Yang, Joshua Somar, Miika Mehine, Maksym Misyura, Olca Baştürk, Alicia Latham, Maria I. Carlo, Michael F. Walsh, Zsofia K. Stadler, Kenneth Offit, Chaitanya Bandlamudi, Meera Hameed, Ping Chi, Jorge S. Reis‐Filho, Özge Ceyhan-Birsoy,
Traditional genetic testing for patients with gastrointestinal stromal tumors (GISTs) focus on those with syndromic features. To assess whether expanded genetic testing of GIST patients could identify hereditary cancer predisposition, we analyzed matched tumor-germline sequencing results from 103 patients with GISTs over a 6-year period. Germline pathogenic/likely pathogenic (P/LP) variants in GIST-associated genes (SDHA, SDHB, SDHC, NF1, KIT) were identified in 69% of patients with KIT/PDGFRA-wildtype ...
Tópico(s): Sarcoma Diagnosis and Treatment
2023 - Nature Portfolio | npj Precision Oncology
Sarah E. Umetsu, Sanjay Kakar, Olca Baştürk, Grace Kim, Deyali Chatterjee, Kwun Wah Wen, Gillian Hale, Nafis Shafizadeh, Soo‐Jin Cho, Julia Whitman, Ryan M. Gill, Kirk D. Jones, Pooja Navale, Emily K. Bergsland, David S. Klimstra, Nancy M. Joseph,
Distinguishing grade 3 pancreatic neuroendocrine tumor (G3 PanNET) from neuroendocrine carcinoma (PanNEC) is a known diagnostic challenge, and accurate classification is critical because clinical behavior and therapies differ. Although current recommendations suggest that immunohistochemistry for p53, Rb, ATRX, and DAXX can distinguish most cases, some cases remain difficult to classify using this approach. In this study, we reviewed 47 high-grade neoplasms originally diagnosed as pancreatic neuroendocrine ...
Tópico(s): Lung Cancer Research Studies
2023 - Elsevier BV | Modern Pathology
Luis A. Rojas, Zachary Sethna, Kevin C. Soares, Cristina Olcese, Nan Pang, Erin Patterson, Jayon Lihm, Nicholas Ceglia, Pablo Guasp, Alexander L. Chu, Rebecca Yu, Adrienne Kaya Chandra, Theresa Waters, Jennifer Jin Ruan, Masataka Amisaki, Abderezak Zebboudj, Zagaa Odgerel, George C. Payne, Evelyna Derhovanessian, Felicitas Müller, Ina Rhee, Mahesh Yadav, Anton Dobrin, Michel Sadelain, Marta Łuksza, Noah A. Cohen, Laura H. Tang, Olca Baştürk, Mithat Gönen, Seth S. Katz, Richard Kinh Gian, Andrew S. Epstein, Parisa Momtaz, Wungki Park, Ryan Sugarman, Anna M. Varghese, Elizabeth Won, Avni M. Desai, Alice C. Wei, Michael I. D’Angelica, T. Peter Kingham, Ira Mellman, Taha Merghoub, Jedd D. Wolchok, Uğur Şahin, Özlem Türeci, Benjamin Greenbaum, William R. Jarnagin, Jeffrey A. Drebin, Eileen M. O’Reilly, Vinod P. Balachandran,
Abstract Pancreatic ductal adenocarcinoma (PDAC) is lethal in 88% of patients 1 , yet harbours mutation-derived T cell neoantigens that are suitable for vaccines 2,3 . Here in a phase I trial of adjuvant autogene cevumeran, an individualized neoantigen vaccine based on uridine mRNA–lipoplex nanoparticles, we synthesized mRNA neoantigen vaccines in real time from surgically resected PDAC tumours. After surgery, we sequentially administered atezolizumab (an anti-PD-L1 immunotherapy), autogene cevumeran ( ...
Tópico(s): CAR-T cell therapy research
2023 - Nature Portfolio | Nature
Boris V. Janssen, Stijn van Roessel, Susan van Dieren, Onno J. de Boer, Volkan Adsay, Olca Baştürk, Lodewijk A.A. Brosens, Fiona Campbell, Deyali Chatterjee, Angela Chou, Claudio Doglioni, Iréne Esposito, Roger Feakins, Talia L. Fuchs, Noriyoshi Fukushima, Anthony J. Gill, Seung‐Mo Hong, Ralph H. Hruban, Jeffrey Kaplan, Alyssa Krasinkas, Claudio Luchini, Chanjuan Shi, Aatur D. Singhi, Elizabeth A. Thompson, Marie‐Louise F. van Velthuysen, Marc G. Besselink, Joanne Verheij, Huamin Wang, Caroline S. Verbeke, Arantza Fariña Sarasqueta,
Abstract Background Most tumour response scoring systems for resected pancreatic cancer after neoadjuvant therapy score tumour regression. However, whether treatment-induced changes, including tumour regression, can be identified reliably on haematoxylin and eosin-stained slides remains unclear. Moreover, no large study of the interobserver agreement of current tumour response scoring systems for pancreatic cancer exists. This study aimed to investigate whether gastrointestinal/pancreatic pathologists ...
Tópico(s): Colorectal Cancer Screening and Detection
2022 - Oxford University Press | British journal of surgery
Guido Rindi, Özgür Mete, Silvia Uccella, Olca Baştürk, Stefano La Rosa, Lodewijk A.A. Brosens, Shereen Ezzat, Wouter W. de Herder, David S. Klimstra, Mauro Papotti, L. Sylvia,
Tópico(s): Lung Cancer Research Studies
2022 - Springer Science+Business Media | Endocrine Pathology
Nicolás A. Giraldo, Esther Drill, Baby A. Satravada, Imane El Dika, A. Rose Brannon, Josephine K. Dermawan, Abhinita Mohanty, Kerem Özcan, Debyani Chakravarty, Ryma Benayed, Efsevia Vakiani, Ghassan K. Abou‐Alfa, Ritika Kundra, Nikolaus Schultz, Bob T. Li, Michael F. Berger, James J. Harding, Marc Ladanyi, Eileen M. O’Reilly, William R. Jarnagin, Chad Vanderbilt, Olca Baştürk, Maria E. Arcila,
Gallbladder carcinoma (GBC) is an uncommon and aggressive disease, which remains poorly defined at a molecular level. Here, we aimed to characterize the molecular landscape of GBC and identify markers with potential prognostic and therapeutic implications.
Tópico(s): RNA modifications and cancer
2022 - American Association for Cancer Research | Clinical Cancer Research
Gaetano Paolino, Iréne Esposito, Seung‐Mo Hong, Olca Baştürk, Paola Mattiolo, Takuma Kaneko, Nicola Veronese, Aldo Scarpa, Volkan Adsay, Claudio Luchini,
Intraductal tubulopapillary neoplasm (ITPN) of the pancreas is a recently recognized pancreatic tumor entity. Here we aimed to determine the most important features with a systematic review coupled with an integrated statistical approach.PubMed, SCOPUS, and Embase were searched for studies reporting data on pancreatic ITPN. The clinicopathological, immunohistochemical, and molecular data were summarized. Then a comprehensive survival analysis and a comparative analysis of the molecular alterations ...
Tópico(s): Neuroendocrine Tumor Research Advances
2022 - Wiley | Histopathology
Vinod P. Balachandran, Luis A. Rojas, Zachary Sethna, Kevin C. Soares, Evelyna Derhovanessian, Felicitas Mueller, Mahesh Yadav, Olca Baştürk, Mithat Gönen, Alice C. Wei, Michael I. D’Angelica, T. Peter Kingham, Benjamin Greenbaum, Taha Merghoub, William R. Jarnagin, Jeffrey A. Drebin, Uğur Şahin, Oezlem Tuereci, Jedd D. Wolchok, Eileen M. O’Reilly,
2516 Background: Pancreas ductal adenocarcinoma (PDAC) is a lethal cancer that claims ̃90% of patients in <24 months of diagnosis. PDAC is also refractory to immunotherapy as most tumors exhibit an immune excluded/desert phenotype. However, although characterized by low mutation rates, most PDACs harbor mutations that can generate immunogenic neoantigens. Here, we report the results of a phase-I trial of autogene cevumeran, a systemic RNA-lipoplex individualized neoantigen-specific immunotherapy (iNeST) ...
Tópico(s): Monoclonal and Polyclonal Antibodies Research
2022 - Lippincott Williams & Wilkins | Journal of Clinical Oncology
Juan Carlos Roa, Olca Baştürk, Volkan Adsay,
Pathological evaluation of gallbladder neoplasia remains a challenge. A significant proportion of cases presents as clinically and grossly inapparent lesions, and grossing protocols are not well established. Among epithelial alterations, pseudo‐pyloric gland metaplasia is ubiquitous and of no apparent consequence, whereas goblet cell metaplasia and a foveolar change in surface cells require closer attention. Low‐grade dysplasia is difficult to objectively define and appears to be clinically inconsequential ...
Tópico(s): Genetic factors in colorectal cancer
2021 - Wiley | Histopathology
Anna M. Varghese, Isha Singh, Ritu Singh, Siddharth Kunte, Joanne F. Chou, Marinela Capanu, Winston Wong, Maeve A. Lowery, Zsofia K. Stadler, Erin Salo‐Mullen, Lily V. Saadat, Alice C. Wei, Marsha Reyngold, Olca Baştürk, Ryma Benayed, Diana Mandelker, Christine A. Iacobuzio‐Donahue, David P. Kelsen, Wungki Park, Kenneth H. Yu, Eileen M. O’Reilly,
Recent evidence suggests a rising incidence of cancer in younger individuals. Herein, we report the epidemiologic, pathologic, and molecular characteristics of a patient cohort with early-onset pancreas cancer (EOPC).
Tópico(s): Renal cell carcinoma treatment
2021 - Oxford University Press | JNCI Journal of the National Cancer Institute