Waldemar Januszczak, John Dugdale, Michael Prescott, Peter Brookes, Diana Wrights, Jon Snow, Mark Stretton, Matthew Wall, Patrick French, Barbara Hall, Alec Stewart, Nigel Botherway, Ronald Ferguson, Jimmy Johnson, Emma Payne, James Clark, Sibylla Brodzinsky, Nigel Denton, Jeffrey Bennett, Rob Hughes, John Peter, Pam Barrett, Emma Moore, Karen Wheeler, Amanda Ursell, Jonathan Miller, Bruce Millar, Jim Munro football editor, J D, Stephen Bayley, Frank Whitford, F A spokesman, Martin Madsen, Ivo Tennant, Christopher Roberts, Alex Todorovic, Kathryn Cooper, Sarah Mower, David Smith, Edin Hamzic, Rory Godson, Melanie Phillips, Neil Wormald, E P, Andrew Sullivan, Clive Davis, Tracey Allen, John Emsley, Cathy Buckle, Mary Wilson, Sarah Hunt, Sally Brown, Dr Roger Henderson, C D, Dick Cheney, Kathy Brewis, Joseph Dunn, Tony Allen-Mills, Simon Wilde, Martin James, Steve Newman, Robert Sandall, Tom Walker, Anthony Sattin, Alison Brace, Robert Winnett, Robert Hewison, Peter Wilson, Roger Anderson, David Dougill, Phll Craigle, Rachel Dobson, Mark Grant, Suzy Hoodless, Philip Kingsley, Simon Kenna, Sue Clayton, H C, Sarah Toyne, David Hewson, Jonathon Carr-Brown, Alasdair Reid, Margarette Driscoll, Hugh Canning, Jeremy Clarkson, Stewart Lee, Edward Porter, Peter Conradi, David Cairns, Louise Taylor, Lewis Haynes, John Waples Deputy City Editor, Patrick Loughlin, Jenny Shields, Cheryl Markosky, Robert Harris, Anita Chaudhuri, John O'Donnell, Douglas Fairbairn, Sean Condon, David Eimer, Joan Smith, Andrew Cunningham, Irwin Steltzer, Victoria Hervey, Nick Gardner, Patrick Garratt, Crystal McClory, Paul Abdale, Peter Parker, Richard Johnson, Antonio Carluccio, Stuart Wavell, Roger Eglin, Stella Bingham, Paul Donovan, Deborah Collcutt, Josephine Smith, Alastair Hendy, Liz Bailey, David Rowley, Stephen Pribul, Denis Quom, Hugh McIlvanney, Jean Loutz, Lucinda Kemeny, Jasper Gerard, Paul Bray, Paul Driver, Garth Pearce, John Humphrys, Sue Fox, John Follain, Peter Windsor, Nicholas Hellen, Richard Brooks, Ian Hawkey, Shelley Von Strunckel, Alex Clark, Danny Sullivan, Stuart Andrews, Phill Baker, Paul Durman, Adam Roche, Claire Mingham-Smith, Mark Edwards, Neil Hynd, Nicola Goldie, Derren Gilhooley, Susan Clark, David Lawrenson, Francess McDonnell, Eben Black Chief Political Correspondent, S Browne, Gavin McGowan, David Cooper, Richard Congdon, Danny O'Brien, David Beckham, Don Beadle, Lois Rogers, Anthony Grayling, Jennifer Asiama, Sue Reid, John O'donnell, Raymond Keene, D Stanton, Gareth Huw Davies, J S, Cosmo Landesman, Uki Goni, Diana Wright, Andy Knott, Eric Watson, Michael Prescott Political Editor, Stephen Jones, Richard Evans, Uzi Mahnaimi, Nick Cain, Mike Donovan, Michael Wright, Peta Bee, M J, Caroline Donald, Dominic Rushe, Lois Rogers Medical correspondent, Pat Butcher, Miranda Seymour, David Walsh, Ann Toms, Anthony Quinn, Sir Peter Squire Chief of the Air Staff, Trevor Lewis, Bryan Appleyard, Chris Jones, Stephen Armstrong, John Elliott, Ron Clarke, David Leigh, Paul Kavanagh, Michael Sheridan Far East Correspondent, R W Johnson, Dave Coombs, Mark Prigg, Ed Case, Roland White, Garth Alexander, David Price, David Churchill, Maurice Chittenden, T N, Richard Brooks Arts Editor, David Hirst, Carmel Joseph Bezzina, Richard Rae, Mark Franchetti, Jonathan Powell, Ray Hutton, Jon Ungoed-Thomas, Martin Ivens, Frank Fitzgibbon, Jonathan Leake, Michael Sheridan, Gary Kemp, Christine Webb, Stephen Varea, Bally Brown, John Harlow, Godfrey Smith, Tim Taylor, John Urbanek, Dipesh Gadher, Hilary Lowe, Mike Wilson, John Waples, Hunter Davies, A A Gill, Matthew Campbell, Brian Glanville, Tom Neale, John Carey, N W, Amber Rust, Tom Robbins, David Sumner Smith, Harvey Jones, Barry O'Donnell, Nick Fielding, Stephen Pettitt, Brian Glockler, Claudia Croft, Chrissy Iley, R H, Tom Walker Diplomatic Correspondent, Sally Kinnes, Peter Semler, Nicholas Hellen Media Editor, Liam Clarke, David Wickers, Graham Hopkins, Jeremy Lazell, Mark Hodson, Andrew Frankel, Graham Norwood, Michael Holroyd, Joe Lovejoy, Jonathan Futrell, Elizabeth Buchan, Rupert Steiner, Terry Burgess, Gordon Brown, Byron Davies, Julia Matthews, Dan Cairns, Tony Perrottet, David Parsley, Professor Alan Bullock, F B, Mrs Mills, David Smith Economics Editor, Tom Deveson, Rowena Hall, Christian Dymond, Paul Richardson, John Bridges, Martin Booth, Bob Dwyer, William Gray, Sean Newsome, India Knight, Walter Ellis, Steve Grant, Joanna Simon, Simon Howard, Ronnie Horesh, Dan Pearson, Lisa Verrico, Rosie Waterhouse, Boris Schapiro, Karen Robinson,
... 12.99 The Soft Boys Underwater Moonlight Matador OLE-500, £15.99 Noah John Had a Burning ...
2001 - Gale Group | Sunday Times HA GDA
... On the generation of long waves Ole Secher Madsen, Ole Secher MadsenSearch for more papers by this author Ole Secher Madsen, Ole Secher MadsenSearch for more papers by this author ...
Tópico(s): Nonlinear Waves and Solitons
1971 - American Geophysical Union | Journal of Geophysical Research Atmospheres
Ole Steen Nielsen, Paul O. Madsen,
... Genitourinary Organs Ole S. Nielsen, and Paul O. Madsen Ole S. NielsenOle S. Nielsen More articles by this ... Urological Association Education and Research, Inc.MetricsAuthor Information Ole S. Nielsen More articles by this author Paul O. Madsen More articles by this author Expand All Advertisement ...
Tópico(s): Urinary Bladder and Prostate Research
1982 - Lippincott Williams & Wilkins | The Journal of Urology
... Cite Icon Cite Search Site Citation Poul Bastrup-Madsen, Ole Greisen; Hypothalamic Obesity in Acute Leukaemia: Report of ...
Tópico(s): Childhood Cancer Survivors' Quality of Life
1963 - Karger Publishers | Acta Haematologica
Ole Steen Nielsen, Svend Maigaard, Niels Frimodt‐Møller, Paul O. Madsen,
... Svend Maigaard, Niels Frimodt-Møller, and Paul O. Madsen Ole S. NielsenOle S. Nielsen , Svend MaigaardSvend Maigaard , Niels Frimodt-MøllerNiels Frimodt-Møller , and Paul O. MadsenPaul O. Madsen View All Author Informationhttps://doi.org/10.1016/ ... Urological Association Education and Research, Inc.MetricsAuthor Information Ole S. Nielsen More articles by this author Svend Maigaard More articles by this author Niels Frimodt-Møller More articles by this author Paul O. Madsen More articles by this author Expand All Advertisement ...
Tópico(s): Surgical site infection prevention
1981 - Lippincott Williams & Wilkins | The Journal of Urology
Jinyan Teng, Yahui Gao, Hongwei Yin, Zhonghao Bai, Shuli Liu, Haonan Zeng, Lijing Bai, Zexi Cai, Bingru Zhao, Xiujin Li, Zhiting Xu, Qing Lin, Zhangyuan Pan, Wenjing Yang, Xiaoshan Yu, Dailu Guan, Yali Hou, Brittney N. Keel, G. A. Rohrer, Amanda K. Lindholm‐Perry, William T. Oliver, María Ballester, Daniel Crespo-Piazuelo, Raquel Quintanilla, Oriol Canela‐Xandri, Konrad Rawlik, Charley Xia, Yuelin Yao, Qianyi Zhao, Wenye Yao, Liu Yang, Houcheng Li, Huicong Zhang, Liao Wang, Tianshuo Chen, Peter Karlskov‐Mortensen, Merete Fredholm, Marcel Amills, Alex Clop, Elisabetta Giuffra, Jun Wu, Xiaodian Cai, Shuqi Diao, Xiangchun Pan, Wei Chen, Jinghui Li, Hao Cheng, Sheng Wang, Guosheng Su, Goutam Sahana, Mogens Sandø Lund, Jack C. M. Dekkers, Luke Kramer, Christopher K. Tuggle, Ryan J. Corbett, Martien A. M. Groenen, Ole Madsen, Marta Gòdia, Dominique Rocha, Mathieu Charles, Congjun Li, Hubert Pausch, Xiaoxiang Hu, Laurent Frantz, Yonglun Luo, Lin Lin, Zhongyin Zhou, Zhe Zhang, Zitao Chen, Leilei Cui, Ruidong Xiang, Xia Shen, Pinghua Li, Ruihua Huang, Guoqing Tang, Mingzhou Li, Yunxiang Zhao, Guoqiang Yi, Zhonglin Tang, Jicai Jiang, Fuping Zhao, Xiaolong Yuan, Xiaohong Liu, Yaosheng Chen, Xuewen Xu, Shuhong Zhao, Pengju Zhao, Chris Haley, Huaijun Zhou, Qishan Wang, Yuchun Pan, Xiangdong Ding, Li Ma, Jiaqi Li, Pau Navarro, Qin Zhang, Bingjie Li, Albert Tenesa, Kui Li, George E. Liu, Zhe Zhang, Lingzhao Fang,
Abstract The Farm Animal Genotype-Tissue Expression (FarmGTEx) project has been established to develop a public resource of genetic regulatory variants in livestock, which is essential for linking genetic polymorphisms to variation in phenotypes, helping fundamental biological discovery and exploitation in animal breeding and human biomedicine. Here we show results from the pilot phase of PigGTEx by processing 5,457 RNA-sequencing and 1,602 whole-genome sequencing samples passing quality control ...
Tópico(s): Cancer-related molecular mechanisms research
2024 - Nature Portfolio | Nature Genetics
B Michelsen, Jacob Petersen, Tina B. Rambrandt, Esper Boel, Allan E. Karlsen, Nicoline Videbæk, Niels Blume, Ole Madsen,
... on: This Site PubMed Google Scholar Ole D. Madsen Ole D. Madsen *Hagedorn Research Institute, Gentofte, Denmark Search for other ... Boel, Allan E. Karlsen, Nicoline Videbæk, Niels Blume, Ole D. Madsen; Differential islet cell expression of two glutamate decarboxylases, ...
Tópico(s): Sirtuins and Resveratrol in Medicine
1993 - Portland Press | Biochemical Society Transactions
René Panduro Poggenborg, Charlotte Wiell, Pernille Bøyesen, Annelies Boonen, Paul Bird, Susanne Juhl Pedersen, IJ Sørensen, Ole Rintek Madsen, Ole Slot, J. Møller, Maria Hasselquist, Olga Kubassova, Mikkel Østergaard,
Objective. In a comparative conventional MRI, dynamic contrast-enhanced (DCE)-MRI, CT and radiography study, the authors aimed to monitor whether inflammation is reduced or even eliminated and damage halted in PsA patients receiving anti-TNF therapy.
Tópico(s): Rheumatoid Arthritis Research and Therapies
2013 - Oxford University Press | Lara D. Veeken
Ole Madsen, Palle Serup, Christina Karlsen, Kaare Lund, Helle V. Petersen, Niels Blume, Frank G. Andersen, Jan Jensen, B Michelsen,
... the study of islet cell differentiation Ole D. Madsen; Ole D. Madsen 1Hagedorn Research Institute, Niels Steensensvej 6, DK-2820 ... Twitter LinkedIn Cite Icon Cite Get Permissions Citation Ole D. Madsen, Palle Serup, Christina Karlsen, Kaare Lund, Helle V. ...
Tópico(s): Microtubule and mitosis dynamics
1993 - Portland Press | Biochemical Society Transactions
Mark J. Kwakkenbos, Mourad Matmati, Ole Madsen, Walter Pouwels, Yongyi Wang, Ronald E. Bontrop, Peter J. Heidt, Robert M. Hoek, Jörg Hamann, Mark J. Kwakkenbos, Mourad Matmati, Ole Madsen, Walter Pouwels, Yongyi Wang, Ronald E. Bontrop, Peter J. Heidt, Robert M. Hoek, Jörg Hamann,
The epidermal growth factor (EGF)-TM7 receptors CD97, EMR1, EMR2, EMR3, and EMR4 form a group of adhesion class heptahelical molecules predominantly expressed by cells of the immune system. These receptors bind cellular ligands through EGF-like domains, localized N-terminal to a large extracellular region. Remarkably, EMR2 possesses a chimeric structure with a seven-span transmembrane (TM7) region most related to EMR3 and an EGF domain region nearly identical to CD97. By comparing EGF-TM7 receptors ...
Tópico(s): T-cell and B-cell Immunology
2006 - Wiley | The FASEB Journal
Ann M. Mc Cartney, Giulio Formenti, Alice Mouton, Diego De Panis, Luísa Marins, Henrique G. Leitão, Genevieve Diedericks, Joseph Kirangwa, Marco Morselli, Judit Salces-Ortiz, Nuria Escudero, Alessio Iannucci, Chiara Natali, Hannes Svardal, Rosa Fernández, Tim De Pooter, Geert Joris, Mojca Stražišar, Jonathan Wood, Katie E Herron, Ole Seehausen, Phillip C. Watts, Felix Shaw, Robert Davey, Alice Minotto, José M. Fernández, Astrid Böhne, Carla Alegria, Tyler Alioto, Paulo C. Alves, Isabel R. Amorim, Jean‐Marc Aury, Niclas Backström, Petr Baldrián, Laima Baltrūnaitė, Endre Barta, Bertrand Bed’Hom, Caroline Belser, Johannes Bergsten, Laurie Bertrand, Helena Bilandija, Mahesh Panchal, Iliana Bista, Mark Blaxter, Paulo A. V. Borges, Guilherme Borges Dias, Mirte Bosse, Tom Brown, Rémy Bruggmann, Elena Buena‐Atienza, Josephine Burgin, Elena Bužan, Alessia Cariani, Nicolas Casadei, Matteo Chiara, Sérgio Chozas, Fedor Čiampor, Angelica Crottini, Corinne Cruaud, Fernando Cruz, Love Dalén, Alessio De Biase, Javier del Campo, Teo Delić, Alice B. Dennis, Martijn F. L. Derks, Maria Angela Diroma, Mihajla Djan, Simone Duprat, Klara Eleftheriadi, Philine G. D. Feulner, Jean‐François Flot, Giobbe Forni, Bruno Fosso, Pascal Fournier, Christine Fournier‐Chambrillon, Toni Gabaldon, Shilpa Garg, Carmela Gissi, Luca Giupponi, Jèssica Gómez‐Garrido, Josefa González, Miguel L. Grilo, Björn Grüning, Thomas Guérin, Nadège Guiglielmoni, Marta Gut, Marcel P. Haesler, Christoph Hahn, Bálint Halpern, Peter W. Harrison, Julia Heintz, Maris Hindrikson, Jacob Höglund, Kerstin Howe, Graham M. Hughes, Benjamin Istace, J. Mark Cock, Franc Janžekovič, Zophonı́as O. Jónsson, Sagane Joye-Dind, Janne J. Koskimäki, Boris Kryštufek, Justyna Kubacka, Heiner Kuhl, Szilvia Kusza, Karine Labadie, Meri Lähteenaro, Henrik Lantz, Anton Lavrinienko, Lucas Leclère, Ricardo J. Lopes, Ole Madsen, Ghislaine Magdelenat, Giulia Magoga, Tereza Manousaki, Tapio Mappes, João Pedro Marques, Gemma I. Martínez‐Redondo, Florian Maumus, Shane McCarthy, Hendrik‐Jan Megens, José Melo‐Ferreira, Sofia L. Mendes, Matteo Montagna, Joao Moreno, Mai‐Britt Mosbech, Mónica Moura, Zuzana Musilová, Eugene W. Myers, Will Nash, Alexander Nater, Pamela Nicholson, Manuel Niell, Reindert Nijland, Benjamin Noël, Karin Norén, Pedro H. Oliveira, Remi‐André Olsen, Lino Ometto, Rebekah A. Oomen, Stephan Ossowski, Vaidas Palinauskas, Snæbjörn Pálsson, Jerome P. Panibe, Joana Paupério, Martina Pavlek, Emilie Payen, Julia Pawłowska, Jaume Pellicer, Graziano Pesole, João Pimenta, Martin Pippel, Anna Maria Pirttilä, Nikos Poulakakis, Jeena Rajan, Rúben M C Rego, Roberto Resendes, Philipp Resl, Ana Riesgo, Patrik Rödin‐Mörch, André E. R. Soares, Carlos Fernandes, María M. Romeiras, Guilherme Roxo, Lukas Rüber, María José Ruiz‐López, Urmas Saarma, Luís P. da Silva, Manuela Sim‐Sim, Lucile Solér, Vítor C. Sousa, Carla Sousa‐Santos, Alberto Spada, Milomir Stefanović, Viktor Stéger, Josefin Stiller, Matthias Stöck, Torsten H. Struck, Hiranya Sudasinghe, Riikka Tapanainen, Christian Tellgren‐Roth, Helena Trindade, Eugene Tukalenko, Ilenia Urso, Benoît Vacherie, Steven M. Van Belleghem, Kees van Oers, Carlos Vargas-Chávez, Nevena Veličković, Noel Vella, Adriana Vella, Cristiano Vernesi, Sara Vicente, Sara Villa, Olga Vinnere Pettersson, Filip Volckaert, Judit Vörös, Patrick Wincker, Sylke Winkler, Claúdio Ciofi, Robert M. Waterhouse, Camila J. Mazzoni,
A genomic database of all Earth's eukaryotic species could contribute to many scientific discoveries; however, only a tiny fraction of species have genomic information available. In 2018, scientists across the world united under the Earth BioGenome Project (EBP), aiming to produce a database of high-quality reference genomes containing all ~1.5 million recognized eukaryotic species. As the European node of the EBP, the European Reference Genome Atlas (ERGA) sought to implement a new decentralised, ...
Tópico(s): Molecular Biology Techniques and Applications
2024 - | npj Biodiversity
MReza Naeemabadi, Birthe Dinesen, Ole Kæseler Andersen, Niels Kragh Madsen, Ole Simonsen, John Hansen,
Telerehabilitation programmes have been attracting increasing attention as a potential alternative to conventional rehabilitation. Video conferencing can facilitate communication between healthcare professionals and patients. However, in certain cases, video conferencing may face practical limitations. As an alternative to real-time conferencing, sensor-based technologies can transmit the acquired data to healthcare providers. This study aimed to design and develop a sensor-based telerehabilitation ...
Tópico(s): Total Knee Arthroplasty Outcomes
2019 - BMJ | BMJ Health & Care Informatics
Sara Kamp Felbo, Charlotte Wiell, Mikkel Østergaard, René Panduro Poggenborg, Pernille Bøyesen, Hilde Berner Hammer, Annelies Boonen, Susanne Juhl Pedersen, Inge Juul Sørensen, Ole Rintek Madsen, Ole Slot, J. Møller, Marcin Szkudlarek, Lene Terslev,
Abstract Objective To investigate the association between clinical joint tenderness and intra- and periarticular inflammation as assessed by ultrasound and MRI in patients with active PsA and to explore if the associations differ according to patient-reported outcomes (PROs) and structural damage. Methods Forty-one patients with active PsA and hand involvement had 76/78 joints examined for swelling/tenderness and ultrasound and MRI of 24 and 12 finger joints, respectively. Synovitis, tenosynovitis, ...
Tópico(s): Autoimmune and Inflammatory Disorders Research
2021 - Oxford University Press | Lara D. Veeken
Morten Hedetoft, Peter Garred, Martin Bruun Madsen, Ole Hyldegaard,
The pathophysiological understanding of the inflammatory response in necrotizing soft-tissue infection (NSTI) and its impact on clinical progression and outcomes are not resolved. Hyperbaric oxygen (HBO2 ) treatment serves as an adjunctive treatment; however, its immunomodulatory effects in the treatment of NSTI remains unknown. Accordingly, we evaluated fluctuations in inflammatory markers during courses of HBO2 treatment and assessed the overall inflammatory response during the first 3 days after ...
Tópico(s): Inflammasome and immune disorders
2021 - Wiley | Physiological Reports
Nadia Schou Vorndran Lund, Morten Borup, Henrik Madsen, Ole Mark, Peter Steen Mikkelsen,
Abstract Combined sewer overflows (CSO) of mixed stormwater and wastewater pollute nearby receiving surface waters and pose a risk to the environment and human health. We use “integrated stormwater inflow control” to mitigate CSO by dynamically controlling the inflow of stormwater to the combined sewer system in real time, expanding the physical space of traditional real‐time control. This control is carried out with model predictive control (MPC), which we base on convex optimization including a linear ...
Tópico(s): Irrigation Practices and Water Management
2020 - Wiley | Water Resources Research
MReza Naeemabadi, Jesper Søndergaard, Anita Klastrup, Anne Philbert Schlünsen, Rikke Emilie Kildahl Lauritsen, John Hansen, Niels Kragh Madsen, Ole Simonsen, Ole Kæseler Andersen, Katherine Kim, Birthe Dinesen,
Telerehabilitation programs can be employed to establish communication between patients and healthcare professionals and empower patients performing their training remotely. This study aimed to identify patients’ requirements after a total knee replacement following a self-training rehabilitation program, leading to the design and development of a telerehabilitation program that can meet the stakeholders’ actual needs. System design, development, and testing were conducted in five iterations based ...
Tópico(s): Stroke Rehabilitation and Recovery
2020 - SAGE Publishing | Health Informatics Journal
Stine Rauff Søndergaard, Poul Henning Madsen, Ole Hilberg, Troels Bechmann, Erik Jakobsen, Karina Mølgaard Jensen, Karina Olling, Karina Dahl Steffensen,
Concerns of increased time consumption and of the impact on clinical decisions may restrain doctors from shared decision making (SDM). This paper evaluates consultation length and decisions made when using an in-consult patient decision aid (PtDA). This prospective cohort study compared an unexposed cohort with a cohort exposed to SDM and a PtDA in two preference-sensitive decision situations: invasive lung cancer diagnostics and adjuvant treatment for early breast cancer. Outcome measures were consultation ...
Tópico(s): Palliative Care and End-of-Life Issues
2020 - Elsevier BV | Patient Education and Counseling
Morten Hedetoft, Martin Bruun Madsen, Lærke Bruun Madsen, Ole Hyldegaard,
Objective To assess the incidence, comorbidities, treatment modalities and mortality in patients with necrotising soft-tissue infections (NSTIs) in Denmark. Design Nationwide population-based registry study. Setting Denmark. Participants Danish residents with NSTI between 1 January 2005 and 31 August 2018. Main outcome measure Incidence of disease per 100 000 person/year and all-cause mortality at day 90 obtained from Danish National Patient Registry and the Danish Civil Registration System. Results ...
Tópico(s): Rabies epidemiology and control
2020 - BMJ | BMJ Open
Stine Rauff Søndergaard, Poul Henning Madsen, Ole Hilberg, Karina Mølgaard Jensen, Karina Olling, Karina Dahl Steffensen,
The objective of this study was to describe the impact on patient-reported outcomes of introducing Shared Decision Making (SDM) and a Patient Decision Aid (PtDA) in the initial process of lung cancer diagnostics. We conducted a prospective cohort study, where a control cohort was consulted according to usual clinical practice. After introducing SDM through a PtDA and training of the staff, the SDM cohort was enrolled in the study. All patients completed four questionnaires: the Decisional Conflict ...
Tópico(s): Patient Satisfaction in Healthcare
2019 - Elsevier BV | Patient Education and Counseling
Nadia Schou Vorndran Lund, Morten Borup, Henrik Madsen, Ole Mark, Karsten Arnbjerg‐Nielsen, Peter Steen Mikkelsen,
Cities increasingly use real-time control of combined sewer systems and green infrastructure to decrease emissions to surface waters, and incorporate infrastructure into the urban landscape to reduce flooding from short, intense rainfall events called cloudbursts, which can cause flash flooding. Inspired by the ‘smart cities’ agenda, we propose the use of integrated stormwater inflow control to dynamically activate cloudburst conveyance infrastructure in the urban landscape as well as green storage ...
Tópico(s): Urban Heat Island Mitigation
2019 - Nature Portfolio | Nature Sustainability
Robert Thänert, Andreas Itzek, Jörn Hoßmann, Domenica Hamisch, Martin Bruun Madsen, Ole Hyldegaard, Steinar Skrede, Trond Bruun, Anna Norrby‐Teglund, Oddvar Oppegaard, Eivind Rath, Torbjørn Nedrebø, Per Arnell, Anders Rosén, Peter Polzik, Marco Bo Hansen, Mattias Svensson, Johanna Snäll, Ylva Karlsson, Michael Nekludov, Eva Medina, Dietmar H. Pieper,
Necrotizing soft tissue infections (NSTIs) are devastating infections caused by either a single pathogen, predominantly Streptococcus pyogenes, or by multiple bacterial species. A better understanding of the pathogenic mechanisms underlying these different NSTI types could facilitate faster diagnostic and more effective therapeutic strategies. Here, we integrate microbial community profiling with host and pathogen(s) transcriptional analysis in patient biopsies to dissect the pathophysiology of streptococcal ...
Tópico(s): Antimicrobial Resistance in Staphylococcus
2019 - Nature Portfolio | Nature Communications
Rasmus E. Christiansen, Joakim Vester-Petersen, S. Madsen, Ole Sigmund,
This paper discusses a non-linear bi-material interpolation scheme for the relative electric permittivity, ϵr, through the refractive index and extinction coefficient. The scheme is tailored for density-based topology optimization of metallic micro- and nano-structures, in electromagnetic problems in the optical wavelength regime. The scheme is shown to exhibit superior properties in the ultraviolet to low infrared wavelength regime, compared to simple linear and inverse interpolation schemes for ...
Tópico(s): Photonic Crystals and Applications
2018 - Elsevier BV | Computer Methods in Applied Mechanics and Engineering
Viktor K. Lund, Kenneth L. Madsen, Ole Kjærulff,
Rab2 is a conserved Rab GTPase with a well-established role in secretory pathway function and phagocytosis. Here we demonstrate that Drosophila Rab2 is recruited to late endosomal membranes, where it controls the fusion of LAMP-containing biosynthetic carriers and lysosomes to late endosomes. In contrast, the lysosomal GTPase Gie/Arl8 is only required for late endosome-lysosome fusion, but not for the delivery of LAMP to the endocytic pathway. We also find that Rab2 is required for the fusion of ...
Tópico(s): Autophagy in Disease and Therapy
2018 - Taylor & Francis | Autophagy
Jonas Stenløkke Madsen, Ole Hylling, Samuel Jacquiod, S. Pécastaings, Lars Hestbjerg Hansen, Leise Riber, Gisle Vestergaard, Søren J. Sørensen,
The second messenger cyclic diguanylate (c-di-GMP) is ubiquitously used by bacteria to modulate and shift between different phenotypes including motility, biofilm formation and virulence. Here we show that c-di-GMP-associated genes are widespread on plasmids and that enzymes that synthesize or degrade c-di-GMP are preferentially encoded on transmissible plasmids. Additionally, expression of enzymes that synthesize c-di-GMP was found to increase both biofilm formation and, interestingly, conjugative ...
Tópico(s): Cancer Research and Treatments
2018 - Springer Nature | The ISME Journal
Mathias Munkholm, Jacob Louis Marott, Lars Bjerre-Kristensen, Flemming Madsen, Ole F. Pedersen, Peter Lange, Børge G. Nordestgaard, Jann Mortensen,
The aim of this study was to determine reference equations for the combined measurement of diffusing capacity of the lung for carbon monoxide (CO) and nitric oxide (NO) ( D LCONO ). In addition, we wanted to appeal for consensus regarding methodology of the measurement including calculation of diffusing capacity of the alveolo-capillary membrane ( D m ) and pulmonary capillary volume ( V c ). D LCONO was measured in 282 healthy individuals aged 18–97 years using the single-breath technique and a breath-hold time ...
Tópico(s): Obstructive Sleep Apnea Research
2018 - European Respiratory Society | European Respiratory Journal
Pia Iben Pietersen, Kristian Rørbæk Madsen, Ole Graumann, Lars Konge, Bjørn Ulrik Nielsen, Christian B. Laursen,
Clinical lung ultrasound examinations are widely used in the primary assessment or monitoring of patients with dyspnoea or respiratory failure. Despite being increasingly implemented, there is no international consensus on education, assessment of competencies, and certification. Today, training is usually based on the concept of mastery learning, but is often unstructured and limited by bustle in a clinical daily life. The aim of the systematic review is to provide an overview of published learning ...
Tópico(s): Radiation Dose and Imaging
2018 - Springer Nature | Critical Ultrasound Journal
Johannes Westman, Bhavya Chakrakodi, Johanna Snäll, Matthias Mörgelin, Martin Bruun Madsen, Ole Hyldegaard, Ariane Neumann, Inga-Maria Frick, Anna Norrby‐Teglund, Lars Björck, Heiko Herwald,
Innate immunity relies on an effective recognition of the pathogenic microorganism as well as on endogenous danger signals. While bacteria in concert with their secreted virulence factors can cause a number of inflammatory reactions, danger signals released at the site of infection may in addition determine the amplitude of such responses, and influence the outcome of the disease. Here we report that protein SIC, Streptococcal Inhibitor of Complement, an abundant secreted protein from Streptococcus ...
Tópico(s): Inflammasome and immune disorders
2018 - Frontiers Media | Frontiers in Immunology
Simon Ladefoged Rasmussen, Henrik Krarup, Kåre Andersson Gotschalck, Martin Berg Johansen, Mogens Tornby Stender, Inge Søkilde Pedersen, Poul Henning Madsen, Ole Thorlacius‐Ussing,
Colorectal cancer (CRC) is one of the most common cancers in the western world. Screening is an efficient method of reducing cancer-related mortality. Molecular biomarkers for cancer in general and CRC in particular have been proposed, and hypermethylated DNA from stool or blood samples are already implemented as biomarkers for CRC screening. We aimed to evaluate the performance of proven hypermethylated DNA promoter regions as plasma based biomarkers for CRC detection.We conducted a cross-sectional ...
Tópico(s): Colorectal Cancer Screening and Detection
2017 - Public Library of Science | PLoS ONE
Sigrid S. Árnadóttir, Maria Jeppesen, Philippe Lamy, Jesper B. Bramsen, Iver Nordentoft, Michael Knudsen, Søren Vang, Mogens Rørbæk Madsen, Ole Thastrup, Jacob Thastrup, Claus L. Andersen,
Patient-derived in vitro cultures of colorectal cancer (CRC) may help guide treatment strategies prior to patient treatment. However, most previous studies have been performed on a single biopsy per tumor. The purpose of this study was to analyze multiple spatially distinct biopsies from CRCs and see how well intratumor heterogeneity (ITH) was recapitulated in matching patient-derived spheroids. Three to five biopsies were collected from six CRC tumors. Each biopsy was split in two; one half was used ...
Tópico(s): Genetic factors in colorectal cancer
2017 - Elsevier BV | Molecular Oncology
Ida Hovdenak Jakobsen, Therese Juul, Inge Bernstein, Peter Christensen, Frank Svendsen Jensen, Christoffer Johansen, Susie Lindhardt Larsen, Søren Laurberg, Mogens Rørbæk Madsen, Ole Thorlacius‐Ussing, Henriette Vind Thaysen,
The main treatment for non-metastatic rectal cancer (RC) is surgical resection. Late adverse effects that are highly prevalent and negatively impact patients' symptom burden and quality of life are: bowel-, urological and sexual dysfunctions; psychological distress; fear of recurrence. Patients and clinicians have requested a more patient-centred follow-up, balancing the focus on detection of recurrence, and physiological and psychological late adverse effects. The current follow-up program primarily ...
Tópico(s): Stoma care and complications
2017 - Taylor & Francis | Acta Oncologica