Dominique Deville‐Bonne, Olivier Sellam, Fabienne Mérola, Ioan Lascu, Michel Desmadril, Michel Véron,
Nucleoside diphosphate (NDP) kinase is the enzyme responsible in the cell for the phosphorylation of nucleoside or deoxynucleoside diphosphates into the corresponding triphosphates at the expense of ATP. Transfer of the gamma-phosphate is very fast (turnover number above 1000 s-1) and involves the phosphorylation of a histidine residue at the active site of the enzyme. We have used intrinsic protein fluorescence of the single tryptophan of Dictyostelium discoideum NDP kinase as a sensitive probe for ...
Tópico(s): Cancer Mechanisms and Therapy
1996 - American Chemical Society | Biochemistry
Faisal Nawaz, Mehdi Zaghouani, Damien Bonne, Olivier Chuzel, Jean Rodriguez, Yoann Coquerel,
Abstract A focused library of chiral imidazolinium salts functionalized with urea‐type hydrogen‐bond donor moieties has been prepared from the chiral pool. The corresponding N‐heterocyclic carbenes were evaluated as organocatalysts in three enantioselective reactions involving homoenolate intermediates generated from enals. The catalysts proved competent in enantioselective cyclopentannulation and γ‐lactonization reactions, a premiere for imidazoline‐based NHCs. This work conveys some new ideas ...
Tópico(s): Synthetic Organic Chemistry Methods
2013 - Wiley | European Journal of Organic Chemistry
Faisal Nawaz, Kishor Mohanan, Laurence Charles, Michel Rajzmann, Damien Bonne, Olivier Chuzel, Jean Rodriguez, Yoann Coquerel,
Abstract Nucleophilic addition of pyridines to benzyne generates zwitterionic adducts that evolve by a rapid intramolecular proton shift to produce the corresponding pyridine carbenes, N ‐phenyl pyrid‐2‐ylidenes. In the presence of electrophilic ketones (isatin derivatives), the pyridylidenes can further react by an original bis‐arylation reaction of the carbonyl compounds involving a formal pyridine CH bond functionalisation. The overall transformation is an unprecedented three‐component reaction ...
Tópico(s): Catalytic C–H Functionalization Methods
2013 - Wiley | Chemistry - A European Journal
Fatah Tidadini, J. Abba, Jean-Louis Quésada, Laurent Villeneuve, Alison Foote, Magalie Baudrant, Aline Bonne, Olivier Gléhen, Bertrand Trilling, Jean‐Luc Faucheron, C. Arvieux,
Tópico(s): Hernia repair and management
2022 - Springer Science+Business Media | International Journal of Colorectal Disease
Felix W. Friedrich, Gilles Dilanian, Patricia Khattar, Denise Juhr, Lucie Gueneau, Philippe Charron, Véronique Fressart, Jean‐Thomas Vilquin, Richard Isnard, Laurent Gouya, Pascale Richard, Naima Hammoudi, Michel Komajda, Gisèle Bonne, Thomas Eschenhagen, Olivier Dubourg, Eric Villard, Lucie Carrier,
Aims The transcription factor Islet‐1 (ISL1) is a marker of cardiovascular progenitors and is essential for mammalian cardiogenesis. An ISL1 haplotype has recently been associated with congenital heart disease. In this study we evaluated whether ISL1 variants are associated with hypertrophic (HCM), dilated (DCM), arrhythmogenic right ventricular cardiomyopathy (ARVC), or with Emery–Dreifuss muscular dystrophy (EDMD). Methods and results The six exon and intron boundaries of ISL1 were screened for genetic ...
Tópico(s): Congenital heart defects research
2012 - Elsevier BV | European Journal of Heart Failure
Jean‐Louis Bonne, Valérie Masson‐Delmotte, Olivier Cattani, Marc Delmotte, Camille Risi, Harald Sodemann, Hans Christian Steen‐Larsen,
Abstract. Since September 2011, a wavelength-scanned cavity ring-down spectroscopy analyser has been remotely operated in Ivittuut, southern Greenland, providing the first record of surface water vapour isotopic composition based on continuous measurements in South Greenland and the first record including the winter season in Greenland. The comparison of vapour data with measurements of precipitation isotopic composition suggest an equilibrium between surface vapour and precipitation. δ18O and deuterium ...
Tópico(s): Groundwater and Isotope Geochemistry
2014 - Copernicus Publications | Atmospheric chemistry and physics
... 142, Issue 3 p. 345-369 Certifier la bonne conduite des entreprises: enjeux et perspectives d'avenir Olivier BOIRAL, Olivier BOIRAL *Université Laval, Québec, Canada. Courriel: ...
Tópico(s): Labor Movements and Unions
2003 - Wiley | Revue internationale du Travail
Konstantin Gribanov, J. Jouzel, Vladislav Bastrikov, Jean‐Louis Bonne, François‐Marie Bréon, Martin Butzin, Olivier Cattani, Valérie Masson‐Delmotte, Nikita Rokotyan, Martin Werner, V. A. Zakharov,
Abstract. Water stable isotopologues provide integrated tracers of the atmospheric water cycle, affected by changes in air mass origin, non-convective and convective processes and continental recycling. Novel remote sensing and in situ measuring techniques have recently offered opportunities for monitoring atmospheric water vapour isotopic composition. Recently developed infrared laser spectrometers allow for continuous in situ measurements of surface water vapour δDv and δ18Ov. So far, very few ...
Tópico(s): Meteorological Phenomena and Simulations
2014 - Copernicus Publications | Atmospheric chemistry and physics
Fatah Tidadini, J. Abba, Jean-Louis Quésada, Magalie Baudrant, Aline Bonne, Alison Foote, Jean‐Luc Faucheron, Olivier Gléhen, Laurent Villeneuve, C. Arvieux,
Tópico(s): Ovarian cancer diagnosis and treatment
2021 - Springer Science+Business Media | Journal of Gastrointestinal Cancer
Marie-Hèlène Malclès, Nathalie Cueille, Francisca Méchali, Olivier Coux, Catherine Bonne-Andréa,
ABSTRACT Papillomaviruses maintain their genomes in a relatively constant copy number as stable extrachromosomal plasmids in the nuclei of dividing host cells. The viral initiator of replication, E1, is not detected in papillomavirus-infected cells. Here, we present evidence that E1 encoded by bovine papillomavirus type 1 is an unstable protein that is degraded through the ubiquitin-proteasome pathway. In a cell-free system derived from Xenopus egg extracts, E1 degradation is regulated by both cyclin ...
Tópico(s): T-cell and Retrovirus Studies
2002 - American Society for Microbiology | Journal of Virology
Nadège Salvi, Aziz Guellich, Pierre Michelet, Alexandre Demoule, Morgan Le Guen, Laure Renou, Gisèle Bonne, Bruno Riou, Olivier Langeron, Catherine Coirault,
Diabetes mellitus is associated with alterations in peripheral striated muscles and cardiomyopathy. We examined diaphragmatic function and fiber composition and identified the role of peroxisome proliferator-activated receptors (PPAR alpha and beta/delta) as a factor involved in diaphragm muscle plasticity in response to type I diabetes.Streptozotocin-treated rats were studied after 8 weeks and compared with their controls. Diaphragmatic strips were stimulated in vitro and mechanical and energetic ...
Tópico(s): Muscle Physiology and Disorders
2010 - Public Library of Science | PLoS ONE
Laure Jacquemin, Nicolien van der Poel, Lana Biot, Joris Schollaert, Fien Bonné, Olivier M. Vanderveken, Marc J. W. Lammers, Vincent Van Rompaey, Annick Gilles,
To estimate the prevalence of tinnitus and hyperacusis in children aged 9-12 years in Flanders, as well as to explore the associations with hearing abilities and listening behaviours.A cross-sectional survey was undertaken in four different Flemish schools. The questionnaire was distributed among 415 children, with a response rate of 97.3%.The prevalence of permanent tinnitus was 10.5% and of hyperacusis was 3.3%. The hyperacusis prevalence was higher in girls (p < .05). Some children reported effects ...
Tópico(s): Vestibular and auditory disorders
2023 - Springer Science+Business Media | European Archives of Oto-Rhino-Laryngology
Laurent Michel, Olivier Maguet,
Le manque de consensus dans les pratiques de soins en matière de traitements de substitution en milieu carcéral participe aux difficultés rencontrées par les équipes sanitaires et à l'insatisfaction exprimée par les détenus. Le travail que nous présentons ici est une proposition de Guide des Bonnes Pratiques applicable à l'ensemble des établissements pénitentiaires et reposant sur la confrontation des textes réglementaires, documents et rapports officiels avec les résultats d'une enquête effectuée ...
Tópico(s): Health, Medicine and Society
2005 - Elsevier BV | L Encéphale
Jeanne Flavigny, Pascale Richard, Richard Isnard, Lucie Carrier, Philippe Charron, Gisèle Bonne, Jean-Fran x E ois Forissier, Michel Desnos, Olivier Dubourg, Michel Komajda, Ketty Schwartz, Bernard Hainque,
Tópico(s): Viral Infections and Immunology Research
1998 - Springer Science+Business Media | Journal of Molecular Medicine
Alexandre Terseleer, Olivier Witmeur,
Le mouvement Lean Startup connaît un retentissement important depuis le début des années 2010. Concrètement, cette nouvelle approche de la préparation d’une jeune entreprise propose de collecter systématiquement, rapidement et par itération successive un maximum de connaissances sur ses clients et leurs besoins. L’objectif est alors d’économiser ses rares ressources et l’aider à atteindre rapidement une bonne adéquation entre son produit et le marché. Face à un tel succès, il est nécessaire de faire ...
Tópico(s): Business Strategy and Innovation
2014 - | Entreprendre & Innover
Mathieu Marx, Isabelle Mosnier, C. Vincent, N.-X. Bonne, D. Bakhos, E. Lescanne, Jonathan Flament, Danièle Bernardeschi, Olivier Sterkers, Bernard Fraysse, Benoît Lepage, Benoît Godey, S. Schmerber, Alain Uziel, Michel Mondain, F. Venail, Olivier Déguine,
Abstract Objectives To describe the treatment choice in a cohort of subjects with single‐sided deafness (SSD) and asymmetric hearing loss (AHL). To assess the reliability of the treatment trials. Design In this national, multicentre, prospective study, the choice of subjects was made after two consecutive trials of Contralateral Routing Of the Signal (CROS) hearing aids and a Bone Conduction Device (BCD) on a headband. Subjects could proceed with one of these two options, opt for cochlear implantation ...
Tópico(s): Hearing Impairment and Communication
2020 - Wiley | Clinical Otolaryngology
Jean‐Pierre Levraud, Olivier Disson, Karima Kissa, Isabelle Bonne, Pascale Cossart, Philippe Herbomel, Marc Lecuit,
ABSTRACT The zebrafish, Danio rerio , has become a popular vertebrate model for the study of infections, mainly because of its excellent optical accessibility at the embryonic and larval stages, when the innate immune system is already effective. We have thus tested the susceptibility of zebrafish larvae to the human pathogen Listeria monocytogenes , a gram-positive, facultative, intracellular bacterium that is known to survive and multiply in professional phagocytes and that causes fatal meningitis ...
Tópico(s): Listeria monocytogenes in Food Safety
2009 - American Society for Microbiology | Infection and Immunity
Wilfried Raimondi, Olivier Baslé, Thierry Constantieux, Damien Bonne, Jean Rodriguez,
Abstract When activated with Takemoto’s catalyst, 1,2‐keto esters constitute versatile nucleophiles in the Michael addition reaction with nitroalkenes affording synthetically valuable, optically active anti‐ adducts in very good yields and high enantiomeric excesses.
Tópico(s): Synthetic Organic Chemistry Methods
2012 - Wiley | Advanced Synthesis & Catalysis
Olivier Payet, L. Maurin, C. Bonne, Agnès Müller,
Glutamate uptake in neurons and glial cells is essential to prevent the persistence of excitotoxic levels of glutamate observed during ischemia. We demonstrated that a short period of hypoxia stimulated the apparent glutamate transport rate in isolated rat retinal cells. The observed increase in glutamate uptake was not affected by glutamate receptor antagonists, protein kinase inhibitors, antioxidant or neo-synthesis inhibitors. However, inhibition of actin polymerization reversed the hypoxia-induced ...
Tópico(s): Retinal Development and Disorders
2004 - Elsevier BV | Neuroscience Letters
Catherine Bonne-Andréa, Malik Kahli, Francisca Méchali, Jean-Marc Lemaı̂tre, Guillaume Bossis, Olivier Coux,
The small ubiquitin-like modifier (SUMO) pathway is essential for the maintenance of genome stability. We investigated its possible involvement in the control of DNA replication during S phase by using the Xenopus cell-free system. Here we show that the SUMO pathway is critical to limit the number and, thus, the density of replication origins that are activated in early S phase. We identified cyclin E, which regulates cyclin-dependent kinase 2 (Cdk2) to trigger origin firing, as an S-phase substrate ...
Tópico(s): Microtubule and mitosis dynamics
2013 - Nature Portfolio | Nature Communications
Ce papier propose d'explorer l'articulation au secteur du bâtiment de l'approche par la démonstration issue de politiques européennes d'innovation technologique, en prenant pour cela le cas du programme européen CONCERTO et de l'expérience française de la ZAC de Bonne à Grenoble. Après avoir resitué les enjeux conceptuels qui sous-tendent l'analyse des pratiques de démonstration (i), cet article donne des éléments de contexte relatifs à la Stratégie de Lisbonne et détaille les ambitions du programme ...
Tópico(s): Regional resilience and development
2015 - Éditions en environnement VertigO | VertigO
Tópico(s): Health, Medicine and Society
2010 - | Corps
Yoshinori L. Doi, Hiroaki Kitaoka, Nobuhiko Hitomi, Manatsu Satoh, Akinori Kimura,
... Richard, MD, Komajda Michel, MD, Carrier Lucie, PhD, Bonne Gisele, PhD, Schwartz Ketty, PhD, Camproux Anne-Claude, PhD, Richard Pascale, PhD, Hainque Bernard, PhD, Dubourg Olivier, MD, Desnos Michel, MD, Hagege Albert, MD, Langlard ...
Tópico(s): Williams Syndrome Research
1999 - Lippincott Williams & Wilkins | Circulation
Comment le système financier peut-il assurer un financement stable des investissements physiques, tout en satisfaisant l’exigence de liquidité des investisseurs financiers qui souhaitent généralement pouvoir récupérer leurs fonds en cas de besoin ? Cet article examine le rôle des différents intervenants dans ce qui ressemble à une mystérieuse quadrature du cercle. Les marchés secondaires de titres, les fonds collectifs d’investissement et les banques fournissent de façon complémentaire ou en compétition ...
Tópico(s): Economic Theory and Policy
2015 - | Revue française d économie
Jérôme Baschet, Jean‐Claude Bonne, Pierre-Olivier Dittmar,
Les images médiévales peuvent être considérées comme des images-objets et celles dont nous traitons ici, les chapiteaux des églises romanes auvergnates, comme des images-lieux 1 .Des images en situation, c'est-à-dire d'abord des images localisées, inscrites dans ce lieu bien particulier qu'est l'édifice ecclésial.Il s'avère donc indispensable de s'interroger sur la façon dont les chapiteaux s'agencent au sein du lieu et sur les interactions complexes entre ces images-objets et le fonctionnement de ...
Tópico(s): Medieval Architecture and Archaeology
2012 - Centre d´Histoire et Théorie des Arts | Images re-vues
Thessa Van Limbergen, Inez Roegiers, Robin Bonné, Federica Mare, Tom Haeldermans, Bjorn Joos, Olivier Nouwen, Jean Manca, Jaco Vangronsveld, Sofie Thijs,
The inclusion of bioaugmented low-cost biochar in current wastewater treatment technologies is a promising way to enhance the removal and degradation of emerging contaminants. In this paper, the properties of two wood waste biochars (wood waste mix - AB, and date palm fiber wood - PDF), and coffee bean husks (COF), produced at four temperatures (350, 450, 500, 550°C) were compared, and investigated in the presence of Geobacter sulfurreducens or a mixed freshwater stream bacterial culture to understand ...
Tópico(s): Adsorption and biosorption for pollutant removal
2022 - Frontiers Media | Frontiers in Environmental Science
J.-F. Forissier, Gisèle Bonne, Christiane Bouchier, Laëtitia Duboscq-Bidot, Pascale Richard, Claudine Wisnewski, Sylvain Briault, Claude Moraine, Olivier Dubourg, Ketty Schwartz, Michel Komajda,
Abstract Background: Mutations in LMNA gene encoding two ubiquitously expressed nuclear proteins, lamins A and C, give rise to up to 7 different pathologies affecting specific tissues. Three of these disorders affect cardiac and/or skeletal muscles with atrio‐ventricular conduction disturbances, dilated cardiomyopathy and sudden cardiac death as common features. Results: A new LMNA mutation (1621C>T, R541C) was found in two members of a French family with a history of ventricular rhythm disturbances ...
Tópico(s): Cardiomyopathy and Myosin Studies
2003 - Elsevier BV | European Journal of Heart Failure
Pascale Richard, Richard Isnard, Lucie Carrier, Olivier Dubourg, Yves Donatien, Bénédicte Mathieu, Gisèle Bonne, Françoise Gary, Philippe Charron, Albert Hagège, Michel Komajda, Ketty Schwartz, Bernard Hainque,
Familial hypertrophic cardiomyopathy is a genetically heterogeneous autosomal dominant disease, caused by mutations in several sarcomeric protein genes. So far, seven genes have been shown to be associated with the disease with the β-myosin heavy chain (MYH7) and the cardiac myosin binding protein C (MYBPC3) genes being the most frequently involved. We performed electrocardiography (ECG) and echocardiography in 15 subjects with hypertrophic cardiomyopathy from a French Caribbean family. Genetic analyses ...
Tópico(s): Congenital heart defects research
1999 - BMJ | Journal of Medical Genetics
Jean-Franc ̧ois Forissier, Lucie Carrier, Hend Farza, Gisèle Bonne, J. Bercovici, Pascale Richard, Bernard Hainque, Philip J. Townsend, Magdi H. Yacoub, Sabine Fauré, Olivier Dubourg, A Millaire, Albert Hagège, Michel Desnos, Michel Komajda, Ketty Schwartz,
Familial hypertrophic cardiomyopathy is a phenotypically and genetically heterogeneous disease. In some families, the disease is linked to the CMH2 locus on chromosome 1q3, in which the cardiac troponin T gene (TNNT2) has been identified as the disease gene. The mutations found in this gene appear to be associated with incomplete penetrance and poor prognosis. Because mutational hot spots offer unique possibilities for analysis of genotype-phenotype correlations, new missense mutations that could ...
Tópico(s): Galectins and Cancer Biology
1996 - Lippincott Williams & Wilkins | Circulation
Alain Makinson, Maurice Hayot, Sabrina Eymard‐Duvernay, Mylène Quesnoy, F. Raffi, L. Thirard, Fabrice Bonnet, Pierre Tattevin, Sophie Abgrall, Xavier Quantin, H. Léna, Sébastien Bommart, Jacques Reynes, Vincent Le Moing,
... Viget, Xavier de la Tribonniere, Thomas Huleux, Séverine Bonne, Raphaël Biekre, Armelle Pasquet, Christophe Allienne, Jean Marie Behra, Agnès Meybeck and Emmanuelle Aissi (Hôpital Gustave Dron, Tourcoing, France); Sophie Abgrall, Olivier Bouchaud, Régine Barruet, François Rouges, Tania Kandel, Fréderic ...
Tópico(s): Pneumonia and Respiratory Infections
2014 - European Respiratory Society | European Respiratory Journal