Olivier Join‐Lambert, Florence Ribadeau-Dumas, Vincent Jullien, Marie-Dominique Kitzis, Jean-Philippe Jaı̈s, Hélène Coignard-Biehler, Hélène Guet‐Revillet, Paul‐Henri Consigny, M. Delage, Xavier Nassif, Olivier Lortholary, Aude Nassif,
The oral clindamycin-rifampin combination is a treatment option of hidradenitis suppurativa (HS) [1–3]. The following report suggests that a significant pharmacokinetic interaction exists between the two drugs that may alter the efficacy of the treatment.In July 2007, the clindamycin and rifampin plasma concentrations were measured in a 26-year-old HS patient who did not respond to a standard dosing regimen of clindamycin (20-40 mg/kg/day, tid) and rifampin (20 mg/kg/day, bid). The trough level [...]
Tópico(s): Chemotherapy-related skin toxicity
2014 - John Libbey Eurotext | European Journal of Dermatology
K El Karoui, F. Méchaï, Florence Ribadeau-Dumas, J-P Viard, Marc Lecuit, Bertille de Barbeyrac, Olivier Lortholary,
An ongoing outbreak of lymphogranuloma venereum (LGV) L2b proctitis, predominantly in HIV-positive men who have sex with men (MSM), has been reported in industrialised countries. A case of reactive arthritis after L2b proctitis is described. This case expands the spectrum of severe complications related to LGV L2b proctitis. Since this infection may be asymptomatic, this organism should be screened for in HIV-positive MSM with symptoms consistent with reactive arthritis.
Tópico(s): Autoimmune and Inflammatory Disorders
2009 - BMJ | Sexually Transmitted Infections
Yaël Zermati, Paulo De Sepulveda, Frédéric Féger, Sébastien Létard, Joëlle Kersual, Nathalie Castéran, Guy Gorochov, Michel Dy, Antoni Ribadeau Dumas, Karim Dorgham, Christophe Parizot, Yann Bieche, Michel Vidaud, Olivier Lortholary, Michel Arock, Olivier Hermine, Patrice Dubreuil,
Tópico(s): Eosinophilic Disorders and Syndromes
2003 - Springer Nature | Oncogene
Olivier Join‐Lambert, Sylvie Fraitag, Florence Ribadeau-Dumas, A. Leguern, Sylvie Behillil, Francisco Castillo, Paul‐Henri Consigny, F Auquier, François Eb, Henri Sevestre, Olivier Lortholary, Xavier Nassif, Aude Nassif,
Auteur(s) : Olivier Join-Lambert1,2, Sylvie Fraitag3, Florence Ribadeau-Dumas1,4, Anne-Sophie Leguern1, Sylvie Behillil1, Francisco-J Del Castillo1,5, Paul-Henri Consigny1, Frederic Auquier6, Francois Eb6, Henri Sevestre6, Olivier Lortholary1,4, Xavier Nassif1,2, Aude Nassif1 1Centre d’Infectiologie, Necker-Pasteur, Institut Pasteur, Centre Medical, 25 rue du Docteur Roux, 75724 Paris Cedex 15, France 2Laboratoire de Microbiologie, Hopital Necker-Enfants malades, 149 rue de [...]
Tópico(s): Fungal Infections and Studies
2009 - John Libbey Eurotext | European Journal of Dermatology
Jean‐Ralph Zahar, Marc Lecuit, Étienne Carbonnelle, Florence Ribadeau-Dumas, Xavier Nassif, Olivier Lortholary,
Until recently, most reported cases of bacteraemia caused by multidrug-resistant strains of Enterobacteriacae producing an extended-spectrum beta-lactamase (ESBL) in Europe have been nosocomial in origin. However, increasing numbers of reports of community-acquired bacteraemia and urinary tract infection caused by ESBL-producing microorganisms suggest that the geographical origin of patients should be taken into account as a risk-factor for possible ESBL production. Early identification of patients ...
Tópico(s): Antibiotic Resistance in Bacteria
2007 - Elsevier BV | Clinical Microbiology and Infection
Olivier Join‐Lambert, H. Coignard, Jean-Philippe Jaı̈s, Hélène Guet‐Revillet, S. Poirée, Sylvie Fraitag, Vincent Jullien, Florence Ribadeau-Dumas, Jacques Thèze, Anne Le Flèche‐Matéos, Sylvie Behillil, Anne Le Flèche‐Matéos, Patrick Berche, Paul‐Henri Consigny, Olivier Lortholary, Xavier Nassif, Aude Nassif,
Antibiotics have been shown to improve hidradenitis suppurativa (HS) patients but complete remission is rare using these treatments.To assess the efficacy and safety of a combination of oral rifampin, moxifloxacin and metronidazole in long-lasting refractory HS.We retrospectively studied 28 consecutive HS patients including 6, 10 and 12 Hurley stage 1, 2 and 3 patients, respectively. Complete remission, defined as a clearance of all inflammatory lesions including hypertrophic scars, was the main ...
Tópico(s): Colorectal and Anal Carcinomas
2010 - Karger Publishers | Dermatology
Marion Gabillot-Carré, Yves Lepelletier, Martine Humbert, Paulo de Sepuvelda, Nadine Benhamouda, Jean Pierre Zappulla, Roland Liblau, Antoine Ribadeau Dumas, François Machavoine, Sébastien Létard, Cédric Baude, Aurélie Hermant, Ying Yang, Jacques Vargaftig, Christine Bodemer, Emmanuel Morélon, Olivier Lortholary, Christian Récher, Guy Laurent, Michel Dy, Michel Arock, Patrice Dubreuil, Olivier Hermine,
Two classes of oncogenic mutations of the c-kit tyrosine kinase have been described: the juxtamembrane domain V560G mutation, which is preferentially found in gastrointestinal stromal tumors (GISTs), and the kinase domain D816V mutation, which is highly representative of systemic mastocytosis (SM). Here we show that both mutations constitutively activate the mammalian target of rapamycin (mTOR) signaling pathway. Surprisingly, the mTOR inhibitor rapamycin induces only apoptosis in HMC-1 cells bearing ...
Tópico(s): PI3K/AKT/mTOR signaling in cancer
2006 - Elsevier BV | Blood
F. Taieb, Alban Le Monnier, E. Bille, F. Lanternier, F. Méchaï, F. Ribadeau-Dumas, E. Maenulein, C. Forge, O. Corriol, X. Nassif, Olivier Lortholary, Jean‐Ralph Zahar,
Vancomycin is still the cornerstone of antibiotic therapy for patients with suspected or proven invasive methicillin resistant Staphylococcus aureus infections. However, clinical and pharmacodynamic studies underline that appropriate doses depend on the infection site, the patient's weight, his renal function, and the bacterial susceptibility.In this prospective study made in a Paris teaching hospital, our two goals were to describe the modalities of infusion and serum concentration obtained during ...
Tópico(s): Bacterial Identification and Susceptibility Testing
2009 - Elsevier BV | Médecine et Maladies Infectieuses
R. Carbajal, K. Ayoub, L. Ribadeau-dumas, M. Olivier-martin, N. Simon,
Tópico(s): Streptococcal Infections and Treatments
1998 - Elsevier BV | Réanimation Urgences
... 184; Aldrich, GCHQ, pp.25–6. 17 L. Ribadeau-Dumas, ‘Essai historique du chiffre de l'Armée de ... mai 1940). 38 Ibid., pp.272–3. 39 Ribadeau-Dumas, ‘Essai historique du chiffre de l'Armée de ... Diary of a Staff Officer, p.36. 44 Ribadeau-Dumas, ‘Essai d'historique du chiffre de l'Armée ...
Tópico(s): European history and politics
2013 - Taylor & Francis | Intelligence & National Security