By Fred Emery Political Editor, By Hugh Noyes Parliamentary Correspondent, From Dessa Trevisan, From a Staff Reporter, By R. W. Shakespeare, By Donald Macityre Labour Reporter, By Paul Routledge Labour Editor, By David Nicholson-Lord, By Hugh Clayton Agriculture Correspondent, By Nicholas Timmins, By Clifford Longley, By Michael Hatfield Political Reporter, By Our Agricultural Correspondent, By peter Hennessy, By Michael Horsnell, By Our Education Correspondent, By Staff Reporters, By Margaret Stone, By a Staff Reporter, By Our Health Services Correspondent, By Michael Baily Transport Correspondent, By Our Planning Reporter, By Our Medical Correspondent, By Lucy Hodges, By Pearce Wright Science Editor, By Our Planning reporter, From Our Correspondent, By Frances Gibb, From Stewart Tendler, By Michael Ratcliffe, By Ian Bradley, By Peter Evans Home Affairs Correspondent, By Our home Affairs Correspondent, From Christopher Thomas, From Peter Nichols, By Tony Samstag, From Our Own Correspondent, From Charles Hargrove, From Alan McGregor, From Patricia Clough, From David Bonavia, From Christopher Walker, From Harry Debelius, From Ian Murray, From Gretel Spitzer, by Patrick Brogan, From David Watts, From Trevor Fishlock, By Michael Frenchman, From Charles Harrison, From Bernard Estrade of Agence France-Presse Ho Chi Minh City, From Ray Kennedy, From Michael Leapman, Ian Murray, Patrick Knight, Ronald Faux, By Peter West Rugby Correspondent, Keith Macklin, By Keith Macklin, By John Witherow, By Rex Bellamy Squash Rackets Correspondent, From Levine Mair, By Michael Phillips Racing Correspondent, John Percival, William Mann, David Robinson, Irving Wardle, Ned Chaillet, Judith Nagley, Richard Owen, Geoffrey Smith, Michael Baily Transport Correspondent, Michael Binyon, Philip Howard, LAWRENCE NORCROSS, , CHRISTOPHER LEVER, , M. H. L. SALZEDO, , BESSBOROUGH, , NICHOLAS HINTON, , ASQUITH GIBBES, , C. G. B. FARWELL, , DIANA M. DOLLERY, , JOHN WALTON, , JAN KENNEDY, , NICHOLAS HERBERT, , T. W. MEADE, , DAVID H. REISSNER, , COSMO HASKARD, , DENNIS CHILES, , ERNEST MEHEW, , From Clive Cookson, By Kenneth Gosling, By Huon Mallalieu, By our Arts Reporter, By Our Arts Reporter, By David Blake Economics Editor, From Peter Norman, By Our Energy Correspondent, Richard Allen, By Our Financial Staff, By Nicholas Hirst and Ronald Pullen, By Roman Eisenstein, By Clifford Webb Midland Industrial Correspondent, Frances Williams, By John Huxley, By Bill Johnstone, By Nicholas Hirst Energy Correspondent, PETER KELVIN, , IAN FELLS, , WALTER GOLDSMITH, , JEAN LEWIS, , A. P. MITCHINSON, , IAN MAIDEN, , BY THE FINANCIAL EDITOR, Ross Davies, Kenneth Owen, By Richard Allen, By Margareta Pagano, By Rosemary Unsworth, By Michael Prest, Peter Waymark, Edited by Peter Davalle,
... 2.7m telephones hearing adjourned, Samim Ocean joins OMA, Business Diary: A tale of two chairmen, Unravelling ...
1980 - Gale Group | TDA
Min‐Yuan Cheng, Moh Nur Sholeh,
... novel optimization algorithm called the optical microscope algorithm (OMA) is developed and applied in this study. Drawing ... of an optical microscope on the target object, OMA uses the naked eye for initial observation and ... objective lens and an eyepiece. The performance of OMA, which is user friendly and does not require ... operating parameters, is validated through two experiments: (1) OMA is compared to nine well-known metaheuristic algorithms ... functions involving multiple dimensions. The results indicate that OMA consistently outperforms all other algorithms and requires a ...
Tópico(s): Resource-Constrained Project Scheduling
2023 - Elsevier BV | Knowledge-Based Systems
Directory of Open Access Journals (DOAJ)
Weiru Yuan, Shuling Hu, Min Li, Yang Li-jia, Lingling Liu, Min Zheng, Zaipei Guo, Zhiqiang Song, Chunlei Zhang, Qingchun Diao, Jinhua Xu, Alexia Richard, Moreshwar Patwardhan, Tianmeng Lyu, Alkaz Uddin, Robert Fogel, Monica Ligueros‐Saylan, Jie Zheng,
... to receive subcutaneous injections of omalizumab 300 mg (OMA 300), omalizumab 150 mg (OMA 150), or placebo. Patients were required to stay ... randomization. FIGURE 1Open in figure viewerPowerPoint Study design OMA 150/300, omalizumab 150/300 mg; sc, subcutaneous ... with USA7 ≤ 6 at week 12) for both OMA 300 and OMA 150. The power was examined according to the ... converge. The difference in LS mean estimates between OMA 300/OMA 150 versus placebo, together with a 95% confidence ... on the primary and all secondary endpoints between OMA 300/OMA 150 versus placebo were included in ...
Tópico(s): Autoimmune Bullous Skin Diseases
2022 - Wiley | Dermatologic Therapy
Torsten Zuberbier, Robert A. Wood, Carsten Bindslev‐Jensen, Alessandro Fiocchi, R. Sharon Chinthrajah, Margitta Worm, A. Deschildre, Montserrat Fernández‐Rivas, Alexandra F. Santos, Xavier Jaumont, Paolo Tassinari,
... of studies have shown encouraging results with omalizumab (OMA) as monotherapy and as an adjunct to oral immunotherapy (OMA+OIT) in patients with single/multiple food allergies.ObjectivesTo evaluate the efficacy and safety of OMA or OMA+OIT in patients with immunoglobulin E (IgE)–mediated ... identify randomized, controlled, and observational studies that assessed OMA as monotherapy or OMA+OIT in patients with IgE-mediated food allergy. ... significant.ResultsIn total, 36 studies were included. The OMA monotherapy (vs pre-OMA) significantly increased the tolerated ...
Tópico(s): Asthma and respiratory diseases
2022 - Elsevier BV | The Journal of Allergy and Clinical Immunology In Practice
B. Gilbert, D. Courvoisier, D. Mongin, K. Lauper, Clémentine Perrier, Rüdiger Müller, Axel Finckh,
... inhibitors (TNFi) and other mode of action bDMARDs (OMA), excluding tsDMARDs. A secondary analysis focusing specifically on ... other tsDMARD, 473 in TNFi and 318 in OMA). Drug maintenance was significantly shorter for TNFi compared ... Drug maintenance was also numerically shorter for the OMA group compared to BARI, but the difference was ... LDA ranged from 63% to 67% (BARI vs OMA p = 0.87; BARI vs TNFi p = 0. ... and remission from 19% to 23% (BARI vs OMA p = 0.30; BARI vs TNFi p = 0. ... than TNFi, and a similar drug maintenance to OMA, both in a bDMARD-naïve population and in ...
Tópico(s): Biosimilars and Bioanalytical Methods
2021 - BMJ | Annals of the Rheumatic Diseases
Guy A. Orban, Marco Lanzilotto, Luca Bonini,
... phAIP are selective for observed manipulative actions (OMAs).OMA selective neurons encode the identity of the observed ... to the level of semantic representation in phAIP.OMA identity may result from the combination of two ... AIP and phAIP allows a stable readout of OMA identity across visual formats, but human neurons exhibit ... AIP and phAIP allows a stable readout of OMA identity across visual formats, but human neurons exhibit ... body movement itself, because its dynamics make the OMA predictable in terms of its motor goal [15. ...
Tópico(s): Psychology of Moral and Emotional Judgment
2021 - Elsevier BV | Trends in Cognitive Sciences
Daiki Matsubara, Shunsuke Takahagi, Ryo� Saito, Akiko Kamegashira, Akio Tanaka, Michihiro Hide,
Omalizumab (OMA) is highly effective for refractory chronic spontaneous urticaria (CSU), but its high cost exerts a great economic ... the economic impact of long-term administration of OMA on patients with CSU in the real-world ... period before through to 12 months after starting OMA in actual clinical practice. This study involved 32 patients who received at least two injections of OMA (300 mg/4 weeks) and achieved good responses ... 14 496/month to ¥104 522 after starting OMA, but reduced to ¥48 810 in 12 months ...
Tópico(s): Autoimmune Bullous Skin Diseases
2020 - Wiley | The Journal of Dermatology
Safaa Mohammed Al-Farsi, Saleem K. Nadaf, Abdullah M. Al‐Sadi, Aman Ullah, Muhammad Farooq,
... 1 than 3 dS m−1. Alfalfa landraces OMA 257, OMA, 245, OMA 270, OMA 315, OMA 211, OMA 117, OMA 56, OMA 239, OMA 148, OMA 131, OMA 95, OMA 263, OMA 262, OMA ...
Tópico(s): Plant responses to water stress
2020 - Springer Science+Business Media | Physiology and Molecular Biology of Plants
Şafak Hatırnaz, Alper Başbuğ, Ebru Hatırnaz, Samer Tannus, Kaan Hatırnaz, Kadir Bakay, Michael H. Dahan,
... due to various forms of oocyte maturation arrest (OMA). Methods Retrospective cohort study. Results In all, 63 women with IVF failure due to OMA were evaluated in this study. According to the Hatirnaz & Dahan classification, 11 (17.5%) women were OMA type 1, 22 (34.9%) were OMA type 2, 0 were OMA type 3, 11 (17.5%) were OMA type 4, and 19 women were OMA type 5 (30.1%). Fewer oocytes were retrieved ... collected in the IVM cycles of women with OMA types 1, 2, and 4. In the OMA type 5 group, 9 (47.4%) day 2 ... transfer was performed for the six patients with OMA type 5 but no clinical pregnancies occurred. Conclusions ...
Tópico(s): Assisted Reproductive Technology and Twin Pregnancy
2020 - Elsevier BV | International Journal of Gynecology & Obstetrics
Cihan Karadağ, Tevfik Yoldemir, Sinem Demircan, Abdülkadir Turgut,
... and bilaterality on ovarian reserve. The patients with OMA were determined by ultrasonographic examination. Fifty patients with unilateral OMA (Group A), 30 patients with bilateral OMA (Group B), and 60 women without ovarian cysts ( ... a significant correlation between serum AMH level and OMA size in Group A (R = −.372, p = .008). ... associated with damage to the ovarian reserve. Increased OMA size is related to decreased AMH levels in patients with OMA. Bilateral OMAs have a more destructive effect on ... we found decreased AMH levels in patients with OMA. The results showed significant negative correlation between OMA ...
Tópico(s): Gynecological conditions and treatments
2019 - Informa | Journal of Obstetrics and Gynaecology
Mathilde Bourdon, Jade Raad, Yaniv Dahan, Louis Marcellin, Chloé Maignien, Marc Even, Khaled Pocate-Cheriet, Marie Charlotte Lamau, Piétro Santulli, Charles Chapron,
... become pregnant. However, the influence of ovarian endometriosis (OMA) on ovarian responsiveness to hyperstimulation has not been ... to stimulation and ART outcomes in women with OMA. Materials and methods We conducted a large observational ... hormone (AMH) levels, 201 infertile women afflicted with OMA (the OMA group) and 402 disease-free women (the control ... accurate diagnosis and staging of their disease. An OMA diagnosis was based on published imaging criteria (obtained ... POR to hyperstimulation was significantly higher for the OMA group than for the control group [62/201 ( ...
Tópico(s): Ovarian function and disorders
2018 - Public Library of Science | PLoS ONE
Project Gutenberg
Bradley E. Chipps, Bob Lanier, Henry Milgrom, A. Deschildre, Gunilla Hedlin, Stanley J. Szefler, Meyer Kattan, Farid Kianifard, Benjamin Ortiz, Tmirah Haselkorn, Ahmar Iqbal, Karin Rosén, Benjamin Trzaskoma, William W. Busse,
... FEV1(pred) ≥60%•Randomized patients (no.):○Total, 334○OMA, 225○Pbo, 109•Mean age (y), range:○OMA, 9.4 (5–12)○Pbo, 9.5 (6-12)•Mean serum IgE level (IU/mL), range:○OMA, 348 (20-1269)○Pbo, 323 (29-1212)•4- ... control achieved with previous ICS, before randomization to OMA or Pbo•16-wk stable-steroid phase: constant ... Minimum dose.•Median percentage reduction of ICS dose: OMA, 100%; Pbo, 66.7%; P = .001•Proportion of patients in whom ICS use was withdrawn completely: OMA, 55%; Pbo, 39%; P = .004•Exacerbation rate during ...
Tópico(s): Respiratory and Cough-Related Research
2017 - Elsevier BV | Journal of Allergy and Clinical Immunology
Izabela Kupryś‐Lipińska, Paweł Majak, Joanna Molińska, Piotr Kuna,
... of severe allergic (IgE-dependent) asthma with omalizumab (OMA) was implemented in Poland in 2013. This observational study evaluated the effectiveness of the Polish OMA program and monitored asthma control after treatment discontinuation. ... 53 patients (23 new/30 continuing treatment) received OMA in the Barlicki Hospital, Poland. Patients were evaluated at baseline and after 16 weeks of OMA treatment by spirometry, mean dose of inhaled corticosteroids ( ... and the Asthma Quality of Life Questionnaire (AQLQ). OMA treatment responses were determined using the global effectiveness ...
Tópico(s): Inhalation and Respiratory Drug Delivery
2016 - BioMed Central | BMC Pulmonary Medicine
Hsiao-Han Wang, Yu‐Chuan Li, Yu‐Chen Huang,
... Scopus (154) Google Scholar 2005Case series3 OMA450 mg OMA q2w for 4 moSystemic steroids and ISA/NANo ... 171) Google Scholar 2006Case series3 OMA150-450 mg OMA q2w for 6 moSystemic steroids and ISA/antibiotics ... Scopus (120) Google Scholar 2006Case series7 OMA300 mg OMA q2w for 3-7 moSystemic steroid/NABeneficial effect ... PubMed Scopus (140) Google Scholar2007Case series11 OMA150 mg OMA q2w for 5 mo (10 cycles)≥1 systemic ... 32) Google Scholar 2010Case series3 OMA300-375 mg OMA q2w for 3 moSystemic steroid and ISA/oral ...
Tópico(s): Allergic Rhinitis and Sensitization
2016 - Elsevier BV | Journal of Allergy and Clinical Immunology
Izabela Kupryś‐Lipińska, Piotr Kuna,
... and observational studies have demonstrated effectiveness of omalizumab (OMA) in the treatment of severe asthma, but the ... The article presents the authors' clinical experience on OMA cessation in routine practice.Due to new reimbursement criteria, OMA therapy has been interrupted in 11 subjects (6 ... of them had an excellent/good response to OMA. The duration of OMA therapy was 67.73 ±11.64 months.Nine ... exacerbation within the first 5 months after the OMA withdrawal. The mean time to the first severe ... 56 ±2.67 weeks. Between the time of OMA cessation and the time of reassessment, the mean ...
Tópico(s): Allergic Rhinitis and Sensitization
2014 - Termedia Publishing House | Advances in Dermatology and Allergology
Caroline A. Spike, Donna Coetzee, Yuichi Nishi, Tugba Guven-Ozkan, Marieke Oldenbroek, Ikuko Yamamoto, Rueyling Lin, David Greenstein,
... two related TIS11 zinc-finger RNA-binding proteins, OMA-1 and OMA-2, are redundantly required for normal oocyte growth and meiotic maturation. We affinity purified OMA-1 and identified associated mRNAs and proteins using ... spectrometry, respectively. As a class, mRNAs enriched in OMA-1 ribonucleoprotein particles (OMA RNPs) have reproductive functions. Several of these mRNAs were tested and found to be targets of OMA-1/2-mediated translational repression, dependent on sequences ... 3′-UTRs). Consistent with a major role for OMA-1 and OMA-2 in regulating translation, OMA- ...
Tópico(s): RNA modifications and cancer
2014 - Oxford University Press | Genetics
... how they select specific mRNA targets for regulation. OMA-1 and OMA-2 are redundant proteins required for oocyte maturation— ... Here, we define the RNA binding specificity of OMA-1 and demonstrate that OMA-1/2 are required to repress the expression ... glp-1 3′-UTR reporter in developing oocytes. OMA-1 binds with high affinity to a conserved ... posterior of fertilized embryos. Our results reveal that OMA-1 is a sequence-specific RNA-binding protein ... transcripts during oogenesis and suggest that interplay between OMA-1 and other factors for overlapping binding sites ...
Tópico(s): Reproductive System and Pregnancy
2013 - Elsevier BV | Journal of Biological Chemistry
Bruno Borghese, Piétro Santulli, Delphine Héquet, Guillaume Pierre, Dominique de Ziegler, Daniel Vaiman, Charles Chapron,
... on the surface of the peritoneum; ii) endometriomas (OMA), which are endometriotic ovarian cysts; and iii) deeply ... in all clinical classes of endometriosis (superficial endometriosis, OMA, and DIE), whereas hypomethylated regions were uniformly spotted ... population to only include patients with histologically proved OMA, but no DIE lesion, per preoperative magnetic resonance ... in light of the disease-known heterogeneous character, OMA probably represents the most distinct and clear-cut ... with chromosome end hypermethylation, are risk markers of OMA. The data were obtained from 444 unrelated women ...
Tópico(s): Family Support in Illness
2012 - Elsevier BV | American Journal Of Pathology
Ida Mav-Golež, David Pahovnik, Michal Bláha, Majda Žigon, Jiřı́ Vohlı́dal,
... of partly self-doped copolymers of 2-methoxyaniline (OMA) with the anilinic acids (ANIA) 2- and 3- ... and impedance spectroscopy. The molar fraction of the OMA units, F1, in a P(OMA/ANIA) copolymer always exceeded the OMA fraction, f1, in the feed monomer mixture since the OMA is much more reactive than any ANIA due ... and the molecular weight (MW) of the P(OMA/ANIA), and with an under-stoichiometric amount of ... reaction time this favored the incorporation of the OMA into the copolymer chains. Increasing the acidity of ...
Tópico(s): Electrochemical sensors and biosensors
2011 - Elsevier BV | Synthetic Metals