Sabino Hazael Avila-Rojas, Omar Emiliano Aparicio‐Trejo, Marco Sánchez-Guerra, Olivier Barbier,
Fluoride is ubiquitous in the environment. Furthermore, drinking water represents the main source of exposure to fluoride for humans. Interestingly, low fluoride concentrations have beneficial effects on bone and teeth development; however, chronic fluoride exposure has harmful effects on human health. Besides, preclinical studies associate fluoride toxicity with oxidative stress, inflammation, and apoptosis. On the other hand, it is well-known that mitochondria play a key role in reactive oxygen ...
Tópico(s): Folate and B Vitamins Research
2022 - Elsevier BV | Environmental Toxicology and Pharmacology
Sabino Hazael Avila-Rojas, Omar Emiliano Aparicio‐Trejo, Alfredo Briones‐Herrera, Omar Noel Medina‐Campos, Laura María Reyes-Fermín, Elena Martínez‐Klimova, Juan Carlos León‐Contreras, Rogelio Hernández‐Pando, Edilia Tapia, José Pedraza‐Chaverrí,
Curcumin has protective effects in several acute kidney injury models, including that induced by potassium dichromate (K2Cr2O7). The protective effect of curcumin in this experimental model has been associated to the preservation of mitochondrial bioenergetics. This study is aimed at evaluating whether or not curcumin's protective effect in mitochondrial bioenergetics is related to the modulation of mitochondrial dynamics and biogenesis. Wistar rats were treated with a single subcutaneous dose of ...
Tópico(s): Vitamin C and Antioxidants Research
2020 - Elsevier BV | Food and Chemical Toxicology
Laura María Reyes-Fermín, Sabino Hazael Avila-Rojas, Omar Emiliano Aparicio‐Trejo, Edilia Tapia, Isabel Rivero, José Pedraza‐Chaverrí,
Cis-dichlorodiammineplatinum II (CDDP) is a chemotherapeutic agent that induces nephrotoxicity by different mechanisms, including oxidative stress, mitochondrial dysfunction, autophagy, and endoplasmic reticulum stress. This study aimed to evaluate if the protective effects of the antioxidant alpha-mangostin (αM) in CDDP-induced damage in proximal tubule Lilly laboratory culture porcine kidney (LLC-PK1) cells, are related to mitochondrial function preservation. It was found that αM co-incubation prevented ...
Tópico(s): Biochemical Acid Research Studies
2019 - Multidisciplinary Digital Publishing Institute | Antioxidants
Alfredo Briones‐Herrera, Sabino Hazael Avila-Rojas, Omar Emiliano Aparicio‐Trejo, Magdalena Cristóbal, Juan Carlos León‐Contreras, Rogelio Hernández‐Pando, Enrique Pinzón, José Pedraza‐Chaverrí, Laura G. Sánchez‐Lozada, Edilia Tapia,
Maleic acid (MA)-induced nephropathy that is characterized by proteinuria, glycosuria, phosphaturia and a deficient urinary acidification and concentration. Sulforaphane (SF) is an indirect antioxidant that shows nephroprotective effects. The aim of the present work was to test the pre-treatment with SF against the MA-induced nephropathy. Wistar rats (230–260 g) were separated in the following groups: control, MA (which received 400 mg/kg of MA), SF + MA (which received MA and 1 mg/kg of SF each day for ...
Tópico(s): Biochemical Acid Research Studies
2018 - Elsevier BV | Food and Chemical Toxicology
Produção Nacional
Revisado por pares
Laura Rocha Guerino, Iracy Lea Pecora, Marcel Sabino Miranda, Cryslaine Aguiar-Silva, Omar dos Santos Carvalho, Roberta Lima Caldeira, Reinaldo José da Silva,
Angiostrongylus cantonensis is causes eosinophilic meningoencephalitis in humans. Worldwide expansion of this nematode is linked to the dispersion of their hosts. This study aimed to determine the prevalence of A. cantonensis infection in Achatina fulica in the nine municipalities that make up Baixada Santista, São Paulo, Brazil.Angiostrongylus cantonensis larvae were analyzed using optical microscopy. We performed polymerase chain reaction and restriction fragment length polymorphism using restriction ...
Tópico(s): Medical and Biological Ozone Research
2017 - Brazilian Society of Tropical Medicine | Revista da Sociedade Brasileira de Medicina Tropical
Sabino Hazael Avila-Rojas, Alejandra Lira-León, Omar Emiliano Aparicio‐Trejo, Laura María Reyes-Fermín, José Pedraza‐Chaverrí,
Curcumin is a hydrophobic polyphenol compound extracted from the rhizome of turmeric. The protective effect of curcumin on kidney damage in multiple experimental models has been widely described. Its protective effect is mainly associated with its antioxidant and anti-inflammatory properties, as well as with mitochondrial function maintenance. On the other hand, occupational or environmental exposure to heavy metals is a serious public health problem. For a long time, heavy metals-induced nephrotoxicity ...
Tópico(s): Heavy Metal Exposure and Toxicity
2019 - Multidisciplinary Digital Publishing Institute | Medicina
Laura María Reyes-Fermín, Omar Emiliano Aparicio‐Trejo, Sabino Hazael Avila-Rojas, Tania Gómez‐Sierra, Elena Martínez‐Klimova, José Pedraza‐Chaverrí,
Endoplasmic reticulum (ER) stress is a normal molecular process induced by the over-accumulation of misfolded or unfolded proteins. ER stress induces the unfolded protein response (UPR), which reduces global protein synthesis, increases ER capacity and protein degradation, to restart ER homeostasis, allowing cell survival. However, the over-induction of UPR can also trigger inflammatory processes, tissue damage and cell death. ER stress is involved in several pathologies, like endothelial dysfunction, ...
Tópico(s): Vitamin C and Antioxidants Research
2020 - Elsevier BV | Food and Chemical Toxicology
Omar Emiliano Aparicio‐Trejo, Sabino Hazael Avila-Rojas, Edilia Tapia, Pedro Rojas‐Morales, Juan Carlos León‐Contreras, Elena Martínez‐Klimova, Rogelio Hernández‐Pando, Laura G. Sánchez‐Lozada, José Pedraza‐Chaverrí,
Recent studies suggest that mitochondrial bioenergetics and oxidative stress alterations may be common mechanisms involved in the progression of renal damage. However, the evolution of the mitochondrial alterations over time and the possible effects that their prevention could have in the progression of renal damage are not clear. Folic acid (FA)-induced kidney damage is a widely used experimental model to induce acute kidney injury (AKI), which can evolve to chronic kidney disease (CKD). Therefore, ...
Tópico(s): Chronic Kidney Disease and Diabetes
2020 - Elsevier BV | Free Radical Biology and Medicine
Sabino Hazael Avila-Rojas, Edilia Tapia, Alfredo Briones‐Herrera, Omar Emiliano Aparicio‐Trejo, Juan Carlos León‐Contreras, Rogelio Hernández‐Pando, José Pedraza‐Chaverrí,
Curcumin exhibits several therapeutic properties. Potassium dichromate (K2Cr2O7)-induced nephropathy is associated with oxidative stress. Reactive oxygen species production affects renal oxygenation that may participate in the progression of renal damage. The aim of the present work was to elucidate whether K2Cr2O7-induced nephropathy is associated to partial O2 pressure (pO2) impairment and if curcumin is able to prevent it. Four groups of rats were studied: control group; K2Cr2O7 group (12.5 mg/kg, ...
Tópico(s): Bone and Joint Diseases
2018 - Elsevier BV | Food and Chemical Toxicology
Omar Emiliano Aparicio‐Trejo, Pedro Rojas‐Morales, Sabino Hazael Avila-Rojas, Juan Carlos León‐Contreras, Rogelio Hernández‐Pando, Alexis Paulina Jiménez‐Uribe, Rodrigo Prieto, Laura G. Sánchez‐Lozada, José Pedraza‐Chaverrí, Edilia Tapia,
Five-sixths nephrectomy (5/6Nx) model is widely used for studying the mechanisms involved in chronic kidney disease (CKD) progression, a kidney pathology that has increased dramatically in recent years. Mitochondrial impairment is a key mechanism that aggravates CKD progression; however, the information on mitochondrial bioenergetics and redox alterations along a time course in a 5/6Nx model is still limited and in some cases contradictory. Therefore, we performed for the first time a time-course ...
Tópico(s): Organ Transplantation Techniques and Outcomes
2020 - Multidisciplinary Digital Publishing Institute | International Journal of Molecular Sciences
Rafik Karaman, Mustafa Khamis, Jehad Abbadi, Ahmad Amro, Mohannad Qurie, Ibrahim Ayyad, Fatima Ayyash, Omar Hamarsheh, Reem Yaqmour, Shlomo Nir, Sabino Aurelio Bufo, Laura Scrano, Sofia Lerman, Shirra Gur-Reznik, Carlos G. Dosoretz,
Kinetic studies on the stability of the pain killer paracetamol in Al-Quds activated sludge demonstrated that paracetamol underwent biodegradation within less than one month to furnish p-aminophenol in high yields. Characterizations of bacteria contained in Al-Quds sludge were accomplished. It was found that Pseudomonas aeruginosa is the bacterium most responsible for the biodegradation of paracetamol to p-aminophenol and hydroquinone. Batch adsorptions of paracetamol and its biodegradation product ( ...
Tópico(s): Environmental remediation with nanomaterials
2016 - Taylor & Francis | Environmental Technology
Omar Tujjar, Ilaria Belloni, Jean‐Michel Hougardy, Sabino Scolletta, Jean‐Louis Vincent, Jacques Créteur, Fabio Silvio Taccone,
Acute kidney injury (AKI) is common in critically ill patients and may contribute to poor outcome. Few data are available on the incidence and impact of AKI in patients suffering from nontraumatic subarachnoid hemorrhage (SAH).We reviewed all patients admitted to our Department of Intensive Care with SAH over a 3-year period. Exclusion criteria were time from SAH symptoms to intensive care unit (ICU) admission >96 hours and ICU stay <48 hours. AKI was defined as sustained oligoanuria (urine output 10% ...
Tópico(s): Intracranial Aneurysms: Treatment and Complications
2016 - Lippincott Williams & Wilkins | Journal of Neurosurgical Anesthesiology
Produção Nacional
Revisado por pares
Kamila Sabino Batista, Vanessa M Cintra, Paulo A F Lucena, Raul Manhães‐de‐Castro, Ana Elisa Toscano, Larissa Pereira Costa, Maria Eduarda Bezerra Sales Queiroz, Suellen Marinho Andrade, Omar Guzmán‐Quevedo, Jailane de Souza Aquino,
This comprehensive review establishes the role of vitamin B12 as adjunct therapy for viral infections in the treatment and persistent symptoms of COVID-19, focusing on symptoms related to the muscle-gut-brain axis. Vitamin B12 can help balance immune responses to better fight viral infections. Furthermore, data from randomized clinical trials and meta-analysis indicate that vitamin B12 in the forms of methylcobalamin and cyanocobalamin may increase serum vitamin B12 levels, and resulted in decreased ...
Tópico(s): Infectious Encephalopathies and Encephalitis
2021 - Oxford University Press | Nutrition Reviews
David E. Kandzari, Raymond R. Townsend, Kazuomi Kario, Felix Mahfoud, Michael A. Weber, Roland E. Schmieder, Stuart J. Pocock, Konstantinos Tsioufis, D. Konstantinidis, James W. Choi, Cara East, Lucas Lauder, Debbie L. Cohen, Taisei Kobayashi, Axel Schmid, David P. Lee, Adrian Ma, Joachim Weil, Tolga Agdirlioglu, Markus P. Schlaich, Sharad Shetty, Chandan Devireddy, Janice P. Lea, Jiro Aoki, Andrew S.P. Sharp, Richard Anderson, Martin Fahy, Vanessa DeBruin, Sandeep Brar, Michael Böhm, Yale Wang, Desmond Jay, Brent McLaurin, Carl Lomboy, Suhail Allaqaband, Fuad Jan, Bharat Gummadi, Marc R. Litt, Fidel Garcia, Jasvindar Singh, Angela L. Brown, James W. Choi, Ashley Paul, Andrew S.P. Sharp, James Coulson, Aravinda Nanjundappa, Ganpat G. Thakker, James Campbell, Benjamin Honton, Bruno Farah, Manesh R. Patel, Antonio Gutiérrez, Crystal C. Tyson, Laura P. Svetkey, Marat Fudim, Neha J. Pagidipati, Schuyler Jones, Sreekanth Vemulapalli, Chandan Devireddy, Ambar Kulshreshtha, Bryan Wells, Janice P. Lea, Bryan Batson, Robert B. Wilkins, Faisal Sharif, Abdullahi Mohamed Khair, Abhishek Wilson Pallippattu, Aishah Alhmoudi, Brian Gaffney, Christian Cawley, Colin Gorry, Hanan Hamed, Jennifer Carron, John Birrane, Liesbeth Rosseel, Mattia Lunardi, Michael J. Cronin, Myles McKittrick, Naeif Almagal, Noman Khalid, Qussai Shehahd, Shirjeel Shahzad, Simone Fezzi, Stanislav Tyulkin, Xavier Armario, Sanjit S. Jolly, Gordon Yip, Jon-David Schwalm, Michael Tsang, Shamir R. Mehta, Philipp Lurz, Christian Binner, Danilo Obradović, Florian Fahr, Ines Richter, Johannes Rotta detto Loria, Karl Fengler, Karl‐Philipp Rommel, Mateo Marin‐Cuartas, Matthias Lerche, Philipp Hartung, Phillip Münch, Robert Höllriegel, Silke John, Satoru Otsuji, Hirofumi Kusumoto, Hiroto Tamaru, Kasumi Ishibuchi, Katsuyuki Hasegawa, Ken Sugimoto, Mikio Kakishita, Rui Ishii, Shin Takiuchi, Shingo Yasuda, Sho Nakabayashi, Wataru Yamamoto, Yorihiko Higashino, Yuji Shimatani, Yusuke Taniguchi, Konstantinos Tsioufis, Alexandros Kasiakogias, D. Konstantinidis, E. Andrikou, Κωνσταντίνος Κωνσταντίνου, Kyriakos Dimitriadis, Theodoros Kalos, Debbie L. Cohen, Garvey Rene, Jordana B. Cohen, Maria Bonanni, Matthew G. Denker, Rasi Wickramisinghe, Robert Wilensky, Tai Kobayashi, Venkatesh Y. Anjan, Yonghong Huan, Walter Herbert Haught, Joshua Krasnow, Alejandro Arias Väsquez, C. Gessler, Christopher Roth, David Drenning, Enrique M. Velasquez, George Soliman, James E. Murphy, Kaushik K. Jain, Michael Butler, Mihir Kanitkar, Phillip Laney, Ross J. Hunter, Shi-Chi Cheng, Thomas C. Wright, Walter Herbert Haught, Neil Chapman, Ahran Arnold, Alexandra N. Nowbar, Azara Janmohamed, Ben Corden, Christopher Cook, Christopher Rajkumar, Daniel Keene, David Thompson, Henry Seligman, James P. Howard, Justin E. Davies, Mark Sweeney, Matthew Shun‐Shin, Michael Foley, Nicholas M. Quaife, Rasha Al‐Lamee, Savvas Hadjiphilippou, Sayan Sen, Yousif Ahmad, Kazuomi Kario, Hayato Shimizu, Hirotaka Waki, Keisuke Narita, Masahisa Shimpo, Satoshi Hoshide, Takahiro Komori, Yukako Ogoyama, Yukiyo Ogata, Yusuke Oba, Mohanned Bisharat, Anton Lishmanov, Mohanned Bisharat, Travis Jeffords, Magdi Ghali, Beth Chia, Rachel Onsrud, Randolph Rough, Jiro Aoki, Daijiro Tomii, Fumiko Mori, Hosei Kikushima, Kai Ninomiya, Kazuyuki Yahagi, Kengo Tanabe, Kôsuke Nakamura, Kota Komiyama, Masaaki Nakase, Masahiko Asami, Naoto Setoguchi, Tetsu Tanaka, Yu Horiuchi, Yusuke Watanabe, Dmitriy N. Feldman, Geoffrey Bergman, Ines Sherifi, Luke Kim, Nivee Amin, Robert M. Minutello, S. Chiu Wong, Stephen McCullough, Richard D’Souza, Andrew S.P. Sharp, Hibba Kurdi, Richard D’Souza, Sarah Statton, Tony Watkinson, Barry Bertolet, Amit Gupta, Benjamin Blossom, Chris Bell, D.C. Hill, Francisco Sierra, James G. Johnson, John Estess, Joseph P. Adams, Katie McDuffie, Lee Ferguson, Nelson Little, Richard Dane Ballard, Roger A. Williams, Wanda Ikeda, William J. Calhoun, William L. Carroll, Avneet Singh, Benjamin J. Hirsh, Perwaiz Meraj, Rajiv Jauhar, Harsh Golwala, Jose Rueda, Kellie Graham, Ramsey Al-Hakim, Robert Rope, David E. Kandzari, Dariush Bahrami, Denise Reedus, Shukri David, Iram Rehman, Khalid Zakaria, Nishit Choksi, Samer Kazziha, Sarwan Kumar, Souheil Saba, Susan Steigerwalt, Yassir Sirajeldin, Omar Hyder, Herbert D. Aronow, Andrea Connors, Douglas Shemin, Clare Bent, Terry Levy, Vivek Kodoth, Markus P. Schlaich, Márcio Galindo Kiuchi, Revathy Carnagarin, Sharad Shetty, Sabino R. Torre, Howard Levitt, Lin Chen, Sarah Fan, Sergio Waxman, Wendy Porr, George Mangos, Brendan Smyth, Cathie Lane, Mark Sader, Kirit Patel, Anjani Rao, Brett Milford, Guneet Ahluwalia, Jaqueline Sennott, Justin Field, Nihar Jena, Stacy Loree, John Graham, Abdul Al‐Hesayen, Akshay Bagai, Junya Shite, Amane Kozuki, Atsushi Suzuki, Eri Masuko, Fumitaka Soga, Hiroyuki Asada,
Renal denervation (RDN) reduces blood pressure (BP) in patients with uncontrolled hypertension in the absence of antihypertensive medications.
Elsevier BV
Omar Tujjar, Giulia Mineo, Antonio Maria Dell’Anna, Belen Poyatos-Robles, Katia Donadello, Sabino Scolletta, Jean‐Louis Vincent, Fabio Silvio Taccone,
Abstract Introduction The aim of this study was to evaluate the incidence and determinants of AKI in a large cohort of cardiac arrest patients. Methods We reviewed all patients admitted, for at least 48 hours, to our Dept. of Intensive Care after CA between January 2008 and October 2012. AKI was defined as oligo-anuria (daily urine output <0.5 ml/kg/h) and/or an increase in serum creatinine (≥0.3 mg/dl from admission value within 48 hours or a 1.5 time from baseline level). Demographics, comorbidities, ...
Tópico(s): Traumatic Brain Injury and Neurovascular Disturbances
2015 - BioMed Central | Critical Care
Evelien Dekker, Karlijn J. Nass, Marietta Iacucci, Alberto Murino, João Sabino, Marek Bugajski, Cristina Carretero, George Cortas, Edward J. Despott, James E. East, Michał F. Kamiński, John Gásdal Karstensen, Martin Keuchel, Mark Löwenberg, A Monged, Olga Maria Nardone, Helmut Neumann, M. Omar, María Pellisé, Laurent Peyrin‐Biroulet, Matthew D. Rutter, Raf Bisschops,
The European Society of Gastrointestinal Endoscopy (ESGE) presents a short list of performance measures for colonoscopy in inflammatory bowel disease (IBD) patients. Current performance measures for colonoscopy mainly focus on detecting (pre)malignant lesions. However, these performance measures are not relevant for all colonoscopy indications in IBD patients. Therefore, our aim was to provide endoscopy services across Europe and other interested countries with a tool for quality monitoring and improvement ...
Tópico(s): Gastric Cancer Management and Outcomes
2022 - Thieme Medical Publishers (Germany) | Endoscopy
Produção Nacional
Rosimeri Ferraz Sabino, Omar Pinto Monteiro, Maria Claudinete Santos Bispo, Fabrício Oliveira Aquino, José Alexandre Silva de Brito, Angela da Silva Andrade,
Esta pesquisa teve o objetivo de investigar a producao de comunicacoes oficiais em uma instituicao de ensino federal, analisando-as diante das orientacoes do Manual de Redacao da Presidencia da Republica, considerando os modelos e fluxos praticados no trato de seus expedientes. Buscaram-se identificar as formas de comunicacoes utilizadas, por meio de expedientes emitidos para o âmbito interno e externo da instituicao, verificando-se o conhecimento dos servidores e gestores sobre a existencia de ...
Tópico(s): Public Health in Brazil
2014 - Editora Univates | Estudo & Debate
Produção Nacional
Revisado por pares
Ricardo Ferreira, Carlos Sabino, Michael Canesche, Omar P. Vilela Neto, José Augusto M. Nacif,
Internet of Things (IoT) protocols and frameworks provide universal access to powerful computing resources regardless of geographical location or infrastructure limitations. Cloud-based platforms such as Google Colab are highlighted for hosting interactive educational materials and applications. Although Colab offers an interactive environment for various disciplines, there is a need to understand how students interact with computational notebooks. This work introduces an MQTT-based toolkit to measure ...
Tópico(s): Experimental Learning in Engineering
2024 - Elsevier BV | Internet of Things
Marek Gluza, João Sabino, Nelly H. Y. Ng, Giuseppe Vitagliano, Marco Pezzutto, Yasser Omar, I. E. Mazets, Marcus Huber, Jörg Schmiedmayer, Jens Eisert,
Recent years have enjoyed an overwhelming interest in quantum thermodynamics, a field of research aimed at understanding thermodynamic tasks performed in the quantum regime. Further progress, however, seems to be obstructed by the lack of experimental implementations of thermal machines in which quantum effects play a decisive role. In this work, we introduce a blueprint of quantum field machines, which—once experimentally realized—would fill this gap. Even though the concept of the QFM presented ...
Tópico(s): Quantum Information and Cryptography
2021 - American Physical Society | PRX Quantum
Sarah Bandali, Sarah Style, Lamine Thiam, Omar Ahmed Omar, Alice Sabino, Eleanor Hukin,
Traditional approaches to development programming with fixed targets and outcomes do not fit complex problems where the pathway to achieve results differs in each context and evolves constantly. Adaptive programming improves responses to complex problems by identifying which solutions bring change. This paper reviews the theory behind adaptive programming approaches and introduces the ‘Pathways of Change’ tool for achieving sustainability results, developed for the multi-country Women’s Integrated ...
Tópico(s): Global Health and Surgery
2021 - Taylor & Francis | Global Public Health
Produção Nacional
Revisado por pares
Omar Ribeiro Santos, Éster Cerdeira Sabino, Vinícius Tostes Carvalho, Bruno Oliveira de Figueiredo Brito, Léa Campos de Oliveira, Ariela Mota Ferreira, Marcelo Alves Maia, Nayana F. A. Gomes, Antônio Luiz Pinho Ribeiro, Maria Carmo Pereira Nunes,
Tópico(s): Viral Infections and Immunology Research
2022 - Springer Science+Business Media | The International Journal of Cardiovascular Imaging
Produção Nacional
Revisado por pares
Maryem Ouarhache, Sandrine Marquet, Amanda Farage Frade, Ariela Mota Ferreira, Bárbara Maria Ianni, Rafael Ribeiro Almeida, João Paulo Silva Nunes, Ludmila Rodrigues Pinto Ferreira, Vagner Oliveira Carvalho Rigaud, Darlan da Silva Cândido, Charles Mady, Ricardo Costa Fernandes Zaniratto, Paula Buck, Magali Torres, Frédéric Gallardo, Pauline Andrieux, Sergio Bydlowsky, Débora Levy, Laurent Abel, Clareci Silva Cardoso, Omar Ribeiro Santos-Junior, Léa Campos de Oliveira, Cláudia Di Lorenzo Oliveira, Maria do Carmo Pereira Nunes, Aurélie Cobat, Jorge Kalil, Antônio Luiz Pinho Ribeiro, Éster Cerdeira Sabino, Edécio Cunha‐Neto, Christophe Chevillard,
Abstract Abstract Cardiomyopathies are an important cause of heart failure and sudden cardiac death. Little is known about the role of rare genetic variants in inflammatory cardiomyopathy. Chronic Chagas disease cardiomyopathy (CCC) is an inflammatory cardiomyopathy prevalent in Latin America, developing in 30% of the 6 million patients chronically infected by the protozoan Trypanosoma cruzi , while 60% remain free of heart disease (asymptomatic (ASY)). The cytokine interferon-γ and mitochondrial dysfunction ...
Tópico(s): Viral Infections and Immunology Research
2021 - Springer Science+Business Media | Journal of Clinical Immunology
A Sgrò, Ruth Blanco‐Colino, WUR Ahmed, Niall Brindl, RR Gujjuri, Pierfrancesco Lapolla, EC Mills, S Pérez-Ajates, AS Soares, Chris Varghese, William Xu, Kenneth A McLean, SJ Chapman, Eloy Espín, James Glasbey, André L. Mihaljević, Dmitri Nepogodiev, Francesco Pata, Gianluca Pellino, Peter Pockney, Nagendra N. Dudi‐Venkata, N Egoroff, Isabella Ludbrook, Kyle Raubenheimer, Toby Richards, Peter Pockney, S Delibegovic, Mirhan Salibasic, T Amjad, Niall Brindl, Colette Dörr-Harim, Naomi Gedeon, Julia Gsenger, André L. Mihaljević, Michael Tachezy, Simone Bini, Gaetano Gallo, Gregorio Tugnoli, Pierfrancesco Lapolla, Francesco Pata, Gianluca Pellino, Arcangelo Picciariello, Mauro Podda, Cristiana Riboni, MJ Machatschek, Anh Nguyen, Matas Jakubauskas, Marius Kryžauskas, Tomas Poškus, SZ Kuiper, Jin Wang, CI Wells, IP Bissett, KM Augestad, Ingeborg Haug Steinholt, AS Soares, BN Vieira, Jovan Juloski, O Anabitarte Bautista, Y El Kasmy El Kasmy, S Pérez-Ajates, Paula Martín-Borregón, Marián Revilla, Eloy Espín, Stephanie Van Straten, MK Aktas, BE Baki, WUR Ahmed, Melika Akhbari, Daniel Baker, Sanchita Bhatia, Steven R. Brown, William Cambridge, Sivesh K. Kamarajah, RA Khaw, Omar Kouli, Kenneth A McLean, EC Mills, Victoria Murray, Isobel M Trout, I H Yasin, Y. J., H Reyhani, KHF Wong, R Pancharatnam, WL Chia, A. D. Walmsley, A Hassane, D Saeed, B Wang, B Walters, Z Nowinka, A Alsaif, Mehdi Ali Mirza, Katharine Foster, J. Luu, Pramath Kakodkar, JT Hughes, Thinesshwary Yogarajah, A Antypas, Atiqur Rahman, Melissa Bradbury, Michael McLarnon, Sana Ehsen Nagi, AM Riad, M Erotocritou, Harry Kyriacou, Viktorija Kaminskaite, S Alfadhel, Q Fatimah Hussain, Anjali Handa, C Massy-Westropp, Svemir Čustović, Rosen Dimov, Hira Mughal, Mihail Slavchev, Tsvetomir Ivanov, Nikolaos Gouvas, Aseel Hegazi, Petr Kocián, MD Kjaer, Anders Mark‐Christensen, Dimitrios Papakonstantinou, Nikolaos Machairas, Tania Triantafyllou, Zoe Garoufalia, Dimitrios Korkolis, Antonio Castaldi, Arcangelo Picciariello, S Giaccari, Gaya Spolverato, G Pagano, Marco Milone, Giulia Turri, F. Colombo, Eugenio Cucinotta, Gaetano Poillucci, Pierfrancesco Lapolla, Simone Bini, Teresa Perra, Roberta Tutino, Francesco Belia, Diego Coletta, Antonio Belli, Daniela Rega, Pasquale Cianci, Giovanni Pirozzolo, M. Di Lena, Fabrizio Perrone, Alessandro Giani, Federico Lovisetto, M Grassia, NS Pipitone Federico, Francesco Ferrara, Alessia Biancafarina, Nicolò Tamini, Giovanni Sinibaldi, F Tuminello, Raffaele Galleano, Diego Sasia, L Bragaglia, A De Manzoni Garberini, Antonio Pesce, F Cassaro, Paolina Venturelli, Gregorio Tugnoli, Gian Luigi Canu, G Esposito, Michela Campanelli, Roberto Cardia, Marco Ricciardiello, Andrea Sagnotta, Giuseppe Canonico, G. De Marco, Antonio Cappiello, Enrico Pinotti, Francesco Carlei, Giorgio Lisi, Giulia Bagaglini, Gaetano Gallo, Anh Nguyen, MJ Machatschek, M Farrugia, E Meima - van Praag, C Monteiro, Mário Pereira, Pedro Botelho, A Quigley, A O’Neill, L Gaule, Lauren Crone, Amber Arnold, Florin Grama, A Beuca, Inna Tulina, Andrey Litvin, Jovan Juloski, Arpád Panyko, M. E. Ossola, J Trujillo Díaz, JM Marín Santos, Ester Alonso Batanero, Sara Gortázar de las Casas, C Soldevila Verdeguer, Enrique Colás‐Ruiz, I Talal El-Abur, Melody García Domínguez, M Delorme, Marc‐Olivier Sauvain, Berk B. Özmen, MK Aktas, BB Ozkan, F Calikoglu, Said Kural, F Zafer, Yunus Kaya, Ali Yalçınkaya, K Kargici, Mustafa Deniz Tepe, OC Tatar, E Kabadayi, A Yıldırım, D Hurmuzlu, Kemal Korkmaz, Pradeep Sharma, R Troller, N Hagan, J Mooney, Alexander Light, Michael Tansey, Deepika Bhojwani, RM McGing, A Mallon, Marc Fadel, C Spilsbury, Rodney James, Stephen O’Brien, Amanda Isaac, S Balasubramanya, Hatem Sadik, Tanzeela Gala, Jy Chen, Benjamin Turner, En Lin Goh, Karim Hassan, Mehrdad Bakhshayesh Karam, P Mason, Nikolaos Tzoumas, T Noton, JK Seehra, Nauman Ahmed, RS Motiwale, Vasantkumar L. Tanna, Andreas A. Argyriou, SK Bylapudi, N Grace, Sehrish Latif, Adam Hounat, JS Kiam, Masooma Zaidi, K Elsamani, Christopher Hughes, Amritha Suresh, LOH Sinan, D El-Dalil, EJM Khoo, EE Salim, Dan Stark, N Minhas, G Fowler, E. Douglas Rees, I Giudiceandrea, A Bardon, P Jayawardena, N Dieseru, Andrew J. Murphy, Charlotte Yates, Karolina Ziółkowska, A Rafie, F Khoda, Michael Okocha, Thomas Ashdown, Parveen Vitish‐Sharma, J Gilliland, Simon Toh, K. A. Jones, A Devine, Alexander Berry, Shannon K. McDonnell, James Olivier, Gillian Richardson, Lim Hj, Parveen Vitish‐Sharma, N. Slim, K Elsayeh, Tarik Sammour,
Many surgeons routinely place intraperitoneal drains after elective colorectal surgery. However, enhanced recovery after surgery guidelines recommend against their routine use owing to a lack of clear clinical benefit. This study aimed to describe international variation in intraperitoneal drain placement and the safety of this practice.COMPASS (COMPlicAted intra-abdominal collectionS after colorectal Surgery) was a prospective, international, cohort study which enrolled consecutive adults undergoing ...
Oxford University Press
Athanasios Kousathanas, Erola Pairo‐Castineira, Konrad Rawlik, A. Stuckey, Christopher A. Odhams, Susan Walker, Clark D Russell, Tomas Malinauskas, Yang Wu, Jonathan Millar, Xia Shen, Katherine S. Elliott, Fiona Griffiths, Wilna Oosthuyzen, Kirstie Morrice, Seán Keating, Bo Wang, Daniel R. Rhodes, Lucija Klarić, Marie Zechner, Nick Parkinson, Afshan Siddiq, Peter Goddard, Sally Donovan, David M. Maslove, Alistair Nichol, Malcolm G. Semple, Tala Zainy, F. Maleady-Crowe, Linda Todd, Shahla Salehi, Julian C. Knight, Greg Elgar, G. C. Chan, Prabhu Arumugam, Christine Patch, Augusto Rendon, David Bentley, Clare Kingsley, Jack A. Kosmicki, Julie Horowitz, Aris Baras, Gonçalo R. Abecasis, Manuel A. R. Ferreira, Anne E. Justice, Tooraj Mirshahi, Matthew T. Oetjens, Daniel J. Rader, Marylyn D. Ritchie, Anurag Verma, Tom Fowler, Manu Shankar‐Hari, Charlotte Summers, Charles Hinds, Peter Horby, Lowell Ling, Daniel F. McAuley, Hugh Montgomery, Peter Openshaw, Paul Elliott, Timothy Walsh, Albert Tenesa, J. Kenneth Baillie, Colin B. Begg, Sara Clohisey, Charles Hinds, Peter Horby, Julian C. Knight, Lowell Ling, David M. Maslove, Daniel F. McAuley, Johnny Millar, Hugh Montgomery, Alistair Nichol, Peter Openshaw, Alexandre C. Pereira, Chris P. Ponting, Kathy Rowan, Malcolm G. Semple, Manu Shankar‐Hari, Charlotte Summers, Timothy Walsh, Latha Aravindan, Ruth Armstrong, Heather Biggs, Ceilia Boz, Adam Brown, Richard E. Clark, Audrey Coutts, J. Terrence Coyle, Louise Cullum, Sukamal Das, Nicky Day, Lorna Donnelly, Esther Duncan, Angie Fawkes, Paul Finernan, Max Head Fourman, Anita Furlong, James Furniss, Bernadette Gallagher, Tammy Gilchrist, Ailsa Golightly, Fiona Griffiths, Katarzyna Hafezi, Debbie Hamilton, Ross Hendry, Andy Law, Dawn Law, R. M. Law, Sarah Law, Rebecca Lidstone-Scott, Louise MacGillivray, Alan Maclean, Hanning Mal, Sarah McCafferty, Ellie Mcmaster, Jen Meikle, Shona C. Moore, Kirstie Morrice, Lee Murphy, Sheena Murphy, Mybaya Hellen, Wilna Oosthuyzen, Chenqing Zheng, Jiantao Chen, Nick Parkinson, Trevor Paterson, Katherine Schon, Andrew Stenhouse, Mihaela Das, Maaike Swets, Helen Szoor-McElhinney, Filip Taneski, Lance Turtle, Tony Wackett, Mairi Ward, Jane Weaver, Nicola Wrobel, Marie Zechner, Gill Arbane, Aneta Bociek, Sara Campos, Neus Grau, Tim Jones, Rosario Lim, Martina Marotti, Marlies Ostermann, Manu Shankar‐Hari, R. Chris Whitton, Zoe Alldis, Raine Astin-Chamberlain, Fatima Bibi, Jack Biddle, Sarah Blow, Matthew L. Bolton, Catherine Borra, Ruth Bowles, Maudrian Burton, Yasmin Choudhury, David Collier, Amber Cox, Amy Easthope, Patrizia Ebano, Stavros Fotiadis, Jana Gurasashvili, Rosslyn Halls, Pippa Hartridge, Delordson Kallon, Jamila Kassam, Ivone Lancoma-Malcolm, Maninderpal Matharu, P. May, Oliver Mitchelmore, Tabitha Newman, Mital Patel, Jane Pheby, Irene Pinzuti, Zoe Prime, Oleksandra Prysyazhna, Julian Shiel, Melanie Taylor, Carey Tierney, S. M. Wood, Anne Zak, Olivier Zongo, Stephen Bonner, Keith Hugill, Jessica Jones, Steven Liggett, Evie Headlam, Nageswar Bandla, Minnie Gellamucho, Michelle Davies, C. C. Thompson, Marwa Abdelrazik, Dhanalakshmi Bakthavatsalam, Munzir Elhassan, Arunkumar Ganesan, Anne Haldeos, Jerónimo Moreno-Cuesta, Dharam Purohit, Rachel Vincent, Kugan Xavier, Rohit Kumar, Alasdair Frater, Malik Saleem, Emma Carter, Samuel Jenkins, Zoe Lamond, Alanna Wall, Jaime Fernandez-Roman, David Hamilton, Emily Johnson, Brian Johnston, Maria Lopez Martinez, Suleman Mulla, David Shaw, Alicia Waite, Victoria Waugh, Ingeborg Welters, Karen Williams, Anna Cavazza, Maeve Cockrell, Eleanor Corcoran, Maria Depante, Clare Finney, Ellen Jerome, Mark McPhail, Monalisa Nayak, Harriet Noble, Kevin O’Reilly, Evita Pappa, Rohit Saha, Sian Saha, John Smith, Abigail Knighton, David Antcliffe, Dorota Banach, Stephen J. Brett, Phoebe Coghlan, Ziortza Fernandez, Anthony Gordon, Roceld Rojo, Sonia Sousa Arias, Maie Templeton, Megan Meredith, Lucy Morris, Lucy Ryan, Amy Clark, Julia Sampson, Cecilia Peters, Martin Dent, Margaret Langley, Saima Ashraf, Shuying Wei, Angela Andrew, Archana Bashyal, Neil Davidson, Paula Hutton, Stuart McKechnie, Jean Wilson, David Baptista, Rebecca Crowe, Rita Fernandes, Rosaleen Herdman-Grant, Anna Joseph, Denise O’Connor, Meryem Allen, Adam Loveridge, India McKenley, Eriko Morino, Andrés Naranjo, Richard Simms, Kathryn Sollesta, Andrew Swain, Harish Venkatesh, Jacyntha Khera, Jonathan Fox, Gillian Andrew, J. Kenneth Baillie, Lucy Barclay, Marie Callaghan, Rachael Campbell, Sarah J. Clark, Dave Hope, Lucy Marshall, Corrienne McCulloch, Kate Briton, Jo Singleton, Sophie Birch, Lutece Brimfield, Zoe Daly, David Pogson, Steve Rose, Angela Nown,
Abstract Critical COVID-19 is caused by immune-mediated inflammatory lung injury. Host genetic variation influences the development of illness requiring critical care 1 or hospitalization 2–4 after infection with SARS-CoV-2. The GenOMICC (Genetics of Mortality in Critical Care) study enables the comparison of genomes from individuals who are critically ill with those of population controls to find underlying disease mechanisms. Here we use whole-genome sequencing in 7,491 critically ill individuals ...
Nature Portfolio
ForestPlots.net, Cecilia Blundo, Julieta Carilla, Ricardo Grau, Agustina Malizia, Lucio R. Malizia, Oriana Osinaga-Acosta, Michael Bird, Matt Bradford, Damien Catchpole, Andrew Ford, Andrew W. Graham, David Hilbert, J. Kemp, Susan Laurance, William F. Laurance, Francoise Yoko Ishida, Andrew Marshall, Catherine E. Waite, Hannsjoerg Woell, Jean‐François Bastin, Marijn Bauters, Hans Beeckman, Pfascal Boeckx, Jan Bogaert, Charles De Cannière, Thalès de Haulleville, Jean‐Louis Doucet, Olivier J. Hardy, Wannes Hubau, Elizabeth Kearsley, Hans Verbeeck, Jason Vleminckx, Steven W. Brewer, Alfredo Alarcón, Alejandro Araujo‐Murakami, E.J.M.M. Arets, Luzmila Arroyo, Ezequiel Chavez, Todd Fredericksen, René Guillén Villaroel, Gloria Gutierrez Sibauty, Timothy J. Killeen, Juan Carlos Licona, John Lleigue, Casimiro Mendoza, Samaria Murakami, Alexander Parada Gutierrez, Guido Pardo, Marielos Peña‐Claros, Lourens Poorter, Marisol Toledo, Jeanneth Villalobos Cayo, Laura Jessica Viscarra, Vincent Antoine Vos, Jorge Ahumada, Everton Almeida, Jarcilene Silva de Almeida‐Cortez, Edmar Almeida de Oliveira, Wesley Alves da Cruz, Atila Alves de Oliveira, Fabrício Alvim Carvalho, Irina Amorim, Ana Andrade, Fernanda Antunes Carvalho, Simone Aparecida Vieira, Ana Carla Medeiros Morato de Aquino, Luiz E. O. C. Aragão, Ana Cláudia Araújo, Marco Antônio Assis, José Ataliba Mantelli Aboin Gomes, Fabrício Baccaro, Plínio Barbosa de Camargo, Paulo Eduardo Barni, Jorcely Barroso, Luis Carlos Bernacci, Kauane Maiara Bordin, Marcelo Brilhante de Medeiros, Igor S. Broggio, José Luís Camargo, Domingos Cardoso, Maria Antônia Carniello, André Luis Casarin Rochelle, Carolina V. Castilho, Antônio Alberto Jorge Farias Castro, Wendeson Castro, Sabina Cerruto Ribeiro, Flávia R. C. Costa, Rodrigo Costa de Oliveira, Italo Coutinho, John Cunha, Lola da Costa, L Ferreira, Richarlly da Costa Silva, Marta da Graça Zacarias Simbine, Vitor de Andrade Kamimura, Haroldo Cavalcante de Lima, Lia de Oliveira Melo, Luciano de Queiroz, José Romualdo de Sousa Lima, Mário M. Espírito‐Santo, Tomas Domingues, Nayane Cristina Candida dos Santos Prestes, Steffan Eduardo Silva Carneiro, Fernando Elias, Gabriel Eliseu, Thaíse Emilio, Camila Laís Farrapo, Letícia Fernandes, Gustavo Ferreira, Joice Ferreira, Leandro Valle Ferreira, Socorro Ferreira, Marcelo Fragomeni Simon, Maria Aparecida Freitas, Queila S. García, Ângelo Gilberto Manzatto, Paulo Maurı́cio Lima de Alencastro Graça, Frederico Augusto Guimarães Guilherme, Eduardo Hase, Niro Higuchi, Mariana Iguatemy, Reinaldo Imbrózio Barbosa, Margarita Jaramillo, Carlos Joly, Joice Klipel, Iêda Leão do Amaral, Carolina Levis, Antonio S. Lima, Maurício Lima Dan, Aline Pontes Lopes, Herison Madeiros, William E. Magnusson, Rubens Manoel dos Santos, Beatriz Schwantes Marimon, Ben Hur Marimon, Roberta Marotti Martelletti Grillo, Luiz Antônio Martinelli, Simone Matias Reis, Salomão de Sousa Medeiros, Milton Serpa de Meira, Thiago Metzker, Paulo S. Morandi, Natanael Moreira do Nascimento, Magna Moura, Sandra Cristina Müller, László Nagy, Henrique Eduardo Mendonça Nascimento, Marcelo Trindade Nascimento, Adriano Nogueira Lima, Raimunda Oliveira de Araújo, Jhonathan Oliveira Silva, M Pansonato, Gabriel Pavan Sabino, Karla Maria Pedra de Abreu, Pablo José Francisco Pena Rodrigues, Maria Teresa Fernandez Piedade, Domingos de Jesus Rodrigues, José Roberto Rodrigues Pinto, Carlos Alberto Quesada, Eliana Ramos, Rafael Ramos, Priscyla Rodrigues, Thaiane R. Sousa, Rafael Salomão, Flávia Delgado Santana, M. A. Scaranello, Rodrigo Scarton Bergamin, Juliana Schietti, Jochen Schöngart, Gustavo Schwartz, Natalino Silva, Marcos Silveira, Cristiana Simão Seixas, Marta da Graça Zacarias Simbine, Ana Cláudia Mércio Loredo Souza, Priscila Souza, Rodolfo Souza, Tereza Cristina Souza Spósito, Edson JF Stefani, Julio Daniel do Vale, Ima Célia Guimarães Vieira, Dora Maria Villela, Marcos Salgado Vital, Harón Abrahim Magalháes Xaud, Kátia J. Zanini, Charles Eugene Zartman, Nur Khalish Hafizhah Ideris, Faizah binti Hj Metali, Kamariah Abu Salim, Muhd Shahruney Saparudin, Rafizah Mat Serudin, Rahayu Sukmaria Sukri, Serge K. Begne, George B. Chuyong, Marie Noël Kamdem Djuikouo, Christelle Gonmadje, Murielle Simo‐Droissart, Bonaventure Sonké, Hermann Taedoumg, Lise Zemagho, Sean C. Thomas, Fidèle Baya, Gustavo Saiz, Javier E. Silva‐Espejo, Dexiang Chen, Alan Hamilton, Yide Li, Tushou Luo, Shukui Niu, Han Xu, Zhang Zhou, Estebán Álvarez, Juan Carlos Andrés Escobar, Henry Arellano-Peña, Jaime Cabezas Duarte, Jhon Calderón, Lina Maria Corrales Bravo, Borish Cuadrado, Hermes Cuadros, Alvaro Duque, Luisa Fernanda Duque, Sandra Milena Espinosa, Rebeca Franke‐Ante, Hernando García, Alejandro Gómez, Roy González‐M., Álvaro Idárraga-Piedrahíta, E. Jiménez, Rubén Jurado, Wilmar López Oviedo, René López Camacho, Omar Aurelio Melo Cruz, Irina Mendoza Polo, Edwin Paky, Karen Pérez, Angel Pijachi, Camila Pizano, Adriana Prieto, Laura Ramos, Zorayda Restrepo Correa, James Richardson, Elkin Rodríguez, Gina M. Rodriguez M., Agustín Rudas, Pablo Stevenson, Markéta Chudomelová, Martin Dančák, Radim Hédl, Stanislav Lhota, Martin Svátek, Jacques M. Mukinzi, Corneille E. N. Ewango, Térese B. Hart, Emmanuel Kasongo Yakusu, Janvier Lisingo, Jean‐Remy Makana, Faustin M. Mbayu, Benjamin Toirambe, John Tshibamba Mukendi, Lars Peter Kvist, Gustav Nebel, Selene Báez, Carlos Céron, Daniel M. Griffith, Juan Ernesto Guevara Andino, David Neill, Walter Palacios, Maria Cristina Peñuela-Mora, Gonzalo Rivas‐Torres, Gorky Villa, Sheleme Demissie, Tadesse Woldemariam Gole, Techane Gonfa, Kalle Ruokolainen, Michel Baisie, Fabrice Bénédet, Wemo Betian, Vincent Bézard, Damien Bonal, Jérôme Chave, Vincent Droissart, Sylvie Gourlet‐Fleury, Annette Hladik, Nicolas Labrière, Pétrus Naisso, Maxime Réjou‐Méchain, Plinio Sist, Lilian Blanc, Benoît Burban, Géraldine Derroire, Aurélie Dourdain, Clément Stahl, Natacha Nssi Bengone, Éric Chézeaux, Fidèle Evouna Ondo,
Tropical forests are the most diverse and productive ecosystems on Earth. While better understanding of these forests is critical for our collective future, until quite recently efforts to measure and monitor them have been largely disconnected. Networking is essential to discover the answers to questions that transcend borders and the horizons of funding agencies. Here we show how a global community is responding to the challenges of tropical ecosystem research with diverse teams measuring forests ...
Elsevier BV
Mari Niemi, Juha Karjalainen, Rachel G. Liao, Benjamin M. Neale, Mark J. Daly, Andrea Ganna, Gita A. Pathak, Shea J. Andrews, Masahiro Kanai, Kumar Veerapen, Israel Fernández‐Cadenas, Eva C. Schulte, Pasquale Striano, M. Marttila, Camelia C. Minică, Eirini Marouli, Mohd Anisul Karim, Frank R. Wendt, Jeanne E. Savage, Laura Sloofman, Guillaume Butler‐Laporte, Han‐Na Kim, Stavroula Kanoni, Yukinori Okada, Jinyoung Byun, Younghun Han, Mohammed Jashim Uddin, George Davey Smith, Cristen J. Willer, Joseph D. Buxbaum, Juha Mehtonen, Hilary K. Finucane, Mattia Cordioli, Alicia R. Martin, Wei Zhou, Bogdan Paşaniuc, Hanna Julienne, Hugues Aschard, Huwenbo Shi, Loïc Yengo, Renato Polimanti, Maya Ghoussaini, Jeremy Schwartzentruber, Ian Dunham, Karolina Chwiałkowska, Margherita Francescatto, Amy Trankiem, Mary K. Balaconis, Lea K. Davis, Sulggi A. Lee, James R. Priest, Alessandra Renieri, Vijay G. Sankaran, David A. van Heel, Patrick Deelen, J. Brent Richards, Tomoko Nakanishi, Les Biesecker, V. Eric Kerchberger, J. Kenneth Baillie, Francesca Mari, Anna Bernasconi, J. Kenneth Baillie, Arif Canakoglu, Brooke N. Wolford, Annika Faucon, Atanu Kumar Dutta, Claudia Schurmann, Emi N. Harry, Ewan Birney, Huy Nguyen, Jamal Nasir, Mari Kaunisto, Matthew Solomonson, Nicole Dueker, Nirmal Vadgama, Sophie Limou, Souad Rahmouni, Hamdi Mbarek, Dima Darwish, Md Mesbah Uddin, Raquel Albertos, Jordi Pérez‐Tur, Ruolin Li, Lasse Folkersen, Ida Moltke, Nils Koelling, Alexander Teumer, Athanasios Kousathanas, Alicia Utrilla, Ricardo A. Verdugo, Ruth Zárate, Carolina Medina‐Gómez, David Gómez-Cabrero, Elena Carnero‐Montoro, Carmen L. Cadilla, Andrés Moreno‐Estrada, Adriana Garmendia, Leire Moya, Bahareh Sedaghati-khayat, Palwendé Romuald Boua, Marie-Julie Favé, Laurent C. Francioli, Audrey Lemaçon, Isabelle Migeotte, Sanjay Patel, Réka Várnai, József Szentpéteri, Csilla Sipeky, Francesca Colombo, Kathrin von Hohenstaufen, Píetro Lió, Costanza L. Vallerga, Qingbo Wang, Yosuke Tanigawa, Hogune Im, Chulho Han, Han Song, Jiwoo Lim, Y.‐A. Lee, Sugyeong Kim, Sangyoon Im, Biljana Atanasovska, Hajar Fauzan Ahmad, Cindy G. Boer, Philip R. Jansen, Lude Franke, Elżbieta Kaja, Dorota Pasko, Ingrid Kennis-Szilagyi, Sergey A. Kornilov, Vid Prijatelj, Ivana Nedeljković, Ilangkumaran Sivanadhan, Sarala Perumal, Sahar Esmaeeli, Nathaniel M. Pearson, Adam Auton, Janie F. Shelton, Anjali J. Shastri, Teresa Filshtein-Sonmez, Daniella Coker, Antony Symons, Jorge Esparza-Gordillo, Stella Aslibekyan, Jared O’Connell, Chelsea Ye, Catherine H. Weldon, Minoli A. Perera, Kevin J. O’Leary, Matthew Tuck, Travis J. O’Brien, David Meltzer, Peter H. O’Donnell, Edith A. Nutescu, Guang Yang, Cristina Alarcón, Stefanie Herrmann, Sophia Mazurek, Jeff Banagan, Zacharia Hamidi, April Barbour, Noora Raffat, Diana Moreno, Paula N. Friedman, Bart Ferwerda, Diederik van de Beek, Matthijs C. Brouwer, Alexander P. J. Vlaar, W. Joost Wiersinga, Daniëlle Posthuma, Elleke Tissink, Aeliko Zwinderman, Emil Uffelmann, Michiel A. van Agtmael, Anne Geke Algera, Frank van Baarle, Diane Bax, Martijn Beudel, Harm Jan Bogaard, Marije K. Bomers, Peter I. Bonta, Lieuwe D. J. Bos, Michela Botta, Justin de Brabander, Godelieve de Bree, Sanne de Bruin, Marianna Bugiani, Esther Bulle, Osoul Chouchane, Alex Cloherty, Dave A. Dongelmans, Paul Elbers, Lucas M. Fleuren, Suzanne E. Geerlings, Bart F. Geerts, Teunis B. H. Geijtenbeek, Armand R. J. Girbes, Abraham Goorhuis, Martin P. Grobusch, Florianne Hafkamp, Laura A. Hagens, Jörg Hamann, Vanessa Harris, Robert Hemke, Sabine Hermans, Leo Heunks, Markus W. Hollmann, Janneke Horn, Joppe W. Hovius, Menno D. de Jong, Rutger Koning, Niels van Mourik, Jeannine F. Nellen, Esther J. Nossent, Frederique Paulus, Edgar Peters, Tom van der Poll, Bennedikt Preckel, Jan M. Prins, Jorinde Raasveld, Tom D. Y. Reijnders, Michiel Schinkel, Marcus J. Schultz, Alex R. Schuurman, Kim Sigaloff, Marry R. Smit, Cornelis Stijnis, Willemke Stilma, Charlotte E. Teunissen, Patrick Thoral, Anissa M. Tsonas, Marc van der Valk, Denise P. Veelo, Heder de Vries, Michèle van Vugt, Dorien Wouters, René Minnaar, Adrie Kromhout, Kees W. J. van Uffelen, Ruud A. Wolterman, Genevieve Roberts, Daniel J. Park, Catherine A. Ball, Marie V. Coignet, Shannon McCurdy, Spencer C. Knight, Raghavendran Partha, Brooke Rhead, Miao Zhang, Nathan Berkowitz, Michael Gaddis, Keith Noto, Luong Ruiz, Miloš Pavlović, Eurie L. Hong, Kristin A. Rand, Ahna R. Girshick, Harendra Guturu, Asher Haug Baltzell, Souad Rahmouni, Julien Guntz, Y Beguin, Sara Pigazzini, Lindokuhle Nkambule, Youssef Bouysran, Adeline Busson, Xavier Peyrassol, Françoise Wilkin, Bruno Pichon, Guillaume Smits, Isabelle Vandernoot, Jean‐Christophe Goffard, Michel Georges, Michel Moutschen, Benoît Misset, Gilles Darcis, Julien Guiot, Laurent Jadot, Samira Azarzar, Patricia Dellot, Stéphanie Gofflot, Sabine Claassen, Axelle Bertrand, Gilles Parzibut, Mathilde Clarinval, Catherine Moermans, Olivier Malaise, Kamilia El Kandoussi, Raphaël Thonon, Pascale Huynen, Alyssia Mesdagh, Sofia Ferreira Melo, Nicolas Jacques, Emmanuel Di Valentin, François Giroule,
The genetic make-up of an individual contributes to the susceptibility and response to viral infection. Although environmental, clinical and social factors have a role in the chance of exposure to SARS-CoV-2 and the severity of COVID-191,2, host genetics may also be important. Identifying host-specific genetic factors may reveal biological mechanisms of therapeutic relevance and clarify causal relationships of modifiable environmental risk factors for SARS-CoV-2 infection and outcomes. We formed ...
Nature Portfolio
Chiara Fallerini, Nicola Picchiotti, Margherita Baldassarri, Kristina Zguro, Sergio Daga, Francesca Fava, Elisa Benetti, Sara Amitrano, Mirella Bruttini, Maria Palmieri, Susanna Croci, Mirjam Lista, Giada Beligni, Floriana Valentino, Ilaria Meloni, Marco Tanfoni, Francesca Minnai, Francesca Colombo, Enrico Cabri, Maddalena Fratelli, Chiara Gabbi, Stefania Mantovani, Elisa Frullanti, Marco Gori, Francis P. Crawley, Guillaume Butler‐Laporte, Brent Richards, Hugo Zeberg, Miklós Lipcsey, Michael Hultström, Kerstin U. Ludwig, Eva C. Schulte, Erola Pairo‐Castineira, J. Kenneth Baillie, Axel Schmidt, Robert Frithiof, Simone Furini, Francesca Montagnani, Mario Tumbarello, Ilaria Rancan, Massimiliano Fabbiani, Barbara Rossetti, Laura Bergantini, Miriana d’Alessandro, Paolo Cameli, David Bennett, Federico Anedda, Simona Marcantonio, Sabino Scolletta, Federico Franchi, Maria Antonietta Mazzei, Susanna Guerrini, Edoardo Conticini, Luca Cantarini, Bruno Frediani, Danilo Tacconi, Chiara Spertilli Raffaelli, Marco Feri, Alice Donati, Raffaele Scala, Luca Guidelli, Genni Spargi, Marta Corridi, Cesira Nencioni, Leonardo Croci, Gian Piero Caldarelli, Maurizio Spagnesi, Davide Romani, Paolo Piacentini, Maria Bandini, Elena Desanctis, Silvia Cappelli, Anna Canaccini, Agnese Verzuri, Valentina Anemoli, Manola Pisani, Agostino Ognibene, Alessandro Pancrazzi, Francesca Mari, Massimo Vaghi, Antonella d’Arminio Monforte, Federica Gaia Miraglia, Mario U. Mondelli, Massimo Girardis, Sophie Venturelli, Stefano Busani, Andrea Cossarizza, Andrea Antinori, Alessandra Vergori, Arianna Emiliozzi, Stefano Rusconi, Matteo Siano, Arianna Gabrieli, Agostino Riva, Daniela Francisci, Elisabetta Schiaroli, Francesco Paciosi, Andrea Tommasi, Pier Giorgio Scotton, Francesca Andretta, Sandro Panese, Stefano Baratti, Renzo Scaggiante, Francesca Gatti, Saverio Giuseppe Parisi, Francesco Castelli, Eugenia Quirós-Roldán, Melania Degli Antoni, Isabella Zanella, Matteo Della Monica, Carmelo Piscopo, Mario Capasso, Roberta Russo, Immacolata Andolfo, Achille Iolascon, Giuseppe Fiorentino, Massimo Carella, Marco Castori, Filippo Aucella, Pamela Raggi, Rita Perna, Matteo Bassetti, Antonio Di Biagio, Maurizio Sanguinetti, Luca Masucci, Alessandra Guarnaccia, Serafina Valente, Oreste De Vivo, Gabriella Doddato, Rossella Tita, Annarita Giliberti, Maria Antonietta Mencarelli, Caterina Lo Rizzo, Anna Maria Pinto, Valentina Perticaroli, Francesca Ariani, Miriam Lucia Carriero, Laura Di Sarno, Diana Alaverdian, Elena Bargagli, Marco Mandalà, Alessia Giorli, Lorenzo Salerni, Patrizia Zucchi, Pierpaolo Parravicini, E. Menatti, Tullio Trotta, Ferdinando Giannattasio, Gabriella Coiro, Fabio Lena, Leonardo Gianluca Lacerenza, Domenico Coviello, Cristina Mussini, Enrico Martinelli, Sandro Mancarella, Luisa Tavecchia, Mary Ann Belli, Lia Crotti, Gianfranco Parati, Maurizio Sanarico, Francesco Raimondi, Filippo Biscarini, Alessandra Stella, Marco Rizzi, Franco Maggiolo, Diego Ripamonti, Claudia Suardi, Tiziana Bachetti, Maria Teresa La Rovere, Simona Sarzi Braga, Maurizio Bussotti, Katia Capitani, Simona Dei, Sabrina Ravaglia, Rosangela Artuso, Elena Andreucci, Giulia Gori, Angelica Pagliazzi, Erika Fiorentini, Antonio Perrella, Francesco Paolo Bianchi, Paola Bergomi, E Catena, Riccardo Colombo, Sauro Luchi, Giovanna Morelli, Paola Petrocelli, Sarah Iacopini, Sara Modica, Silvia Baroni, Francesco Vladimiro Segala, Francesco Menichetti, Marco Falcone, Giusy Tiseo, Chiara Barbieri, Tommaso Matucci, Davide Grassi, Claudio Ferri, Franco Marinangeli, Francesco Brancati, M. A. Vincenti, Valentina Borgo, Stefania Lombardi, Mirco Lenzi, Massimo Antonio Di Pietro, Francesca Vichi, Benedetta Romanin, Letizia Attala, Cecilia Costa, Andrea Gabbuti, Roberto Mené, Umberto Zuccon, Lucia Vietri, Stefano Ceri, Pietro Pinoli, Patrizia Casprini, Giuseppe Merla, Gabriella Maria Squeo, Marcello Maffezzoni, Raffaele Bruno, Marco Vecchia, Marta Colaneri, Serena Ludovisi, Yanara Marincevic-Zuniga, Jessica Nordlund, Tomas Luther, Anders Larsson, Katja Hanslin Anna Gradin, Sarah Galien, Sara Bulow Anderberg, Jacob Rosén, Sten Rubertsson, Hugo Zeberg, Robert Frithiof, Miklós Lipcsey, Michael Hultström, Sara Clohisey Peter Horby, Johnny Millar, Julian C. Knight, Hugh Montgomery, David M. Maslove, Lowell Ling, Alistair Nichol, Charlotte Summers, Timothy Walsh, Charles Hinds, Malcolm G. Semple, Peter Openshaw, Manu Shankar‐Hari, Antonia Ho, Daniel F. McAuley, Chris P. Ponting, Kathy Rowan, J. Kenneth Baillie, Fiona Griffiths, Wilna Oosthuyzen, Jen Meikle, Paul Finernan, James Furniss, Ellie Mcmaster, Andy Law, Sara Clohisey, J. Kenneth Baillie, Trevor Paterson, Tony Wackett, Ruth Armstrong, Lee Murphy, Angie Fawkes, Richard Clark, Audrey Coutts, Lorna Donnelly, Tammy Gilchrist, Katarzyna Hafezi, Louise MacGillivray, Alan Maclean, Sarah McCafferty, Kirstie Morrice, Jane Weaver, Ceilia Boz, Ailsa Golightly, M. M. Ward, Hanning Mal, Helen Szoor-McElhinney, Adam Brown, Ross Hendry, Andrew Stenhouse, Louise Cullum, Dawn Law, Sarah Law, R. M. Law, Max Head Fourman, Maaike Swets, Nicky Day, Filip Taneski, Esther Duncan, Francesca Mari,
The combined impact of common and rare exonic variants in COVID-19 host genetics is currently insufficiently understood. Here, common and rare variants from whole-exome sequencing data of about 4000 SARS-CoV-2-positive individuals were used to define an interpretable machine-learning model for predicting COVID-19 severity. First, variants were converted into separate sets of Boolean features, depending on the absence or the presence of variants in each gene. An ensemble of LASSO logistic regression ...
Springer Science+Business Media
Michael D. Kessler, Douglas P. Loesch, James A. Perry, Nancy L. Heard‐Costa, Daniel Taliun, Brian E. Cade, Heming Wang, Michelle Daya, John Ziniti, Soma Datta, Juan C. Celedón, Manuel E. Soto-Quirós, Lydiana Ávila, Scott T. Weiss, Kathleen C. Barnes, Susan Redline, Ramachandran S. Vasan, Andrew D. Johnson, Rasika A. Mathias, Ryan D. Hernandez, James G. Wilson, Deborah A. Nickerson, Gonçalo R. Abecasis, Sharon R. Browning, Sebastian Zöllner, Jeffrey R. O’Connell, Braxton D. Mitchell, Timothy D. O’Connor, Sanne E. Aalbers, Moustafa Abdalla, Omar Abdul‐Rahman, Gonçalo R. Abecasis, Avinash Abhyankar, Indra Adrianto, François Aguet, Rachel Akers, Rafet Al-Tobasei, Christine M. Albert, Micheala A. Aldred, Laura Almasy, Márcio Rodrigues de Almeida, Álvaro Alonso, Seth A. Ament, Elizabeth Ampleford, Ping An, Christopher D. Anderson, Charlotte Andersson, Pramod Anugu, Elizabeth L. Appelbaum, Kristin Ardlie, Dan Arking, Sebastian M. Armasu, Donna K. Arnett, Heather T Arruda, Marios Arvanitis, Allison E. Ashley‐Koch, Aneel A. Ashrani, Stella Aslibekyan, Tim Assimes, Elizabeth J. Atkinson, Paul L. Auer, Thomas R. Austin, Christy L. Avery, Julián Ávila-Pacheco, Paul Avillach, Abraham Aviv, Dimitrios Avramopoulos, Christie M. Ballantyne, Pallavi Balte, Michael J. Bamshad, Mike Bancks, John Barnard, Kathleen C. Barnes, R. Graham Barr, Emily Barron‐Casella, Traci M. Bartz, Lucas Barwick, Saonli Basu, Alexis Battle, Michaël Baumann, David Beame, Terri Beaty, Gerald J. Beck, Lewis C. Becker, Diane M. Becker, Rebecca Beer, Ferdouse Begum, Alexa S. Beiser, Amber L. Beitelshees, Emelia J. Benjamin, Takis Benos, Hanna Berk-Rauch, Zachary M Besich, Marcos Bezerra, Surya P. Bhatt, Wenjian Bi, Alexander G. Bick, Larry Bielak, Mary L. Biggs, Joshua C. Bis, Thomas W. Blackwell, John Blangero, Eugene Bleecker, Brandon M. Blobner, Toby Bloom, Elizabeth Blue, Corneliu Bodea, Mike Boehnke, Eric Boerwinkle, Sílvia Bonàs‐Guarch, Donald W. Bowden, Michael Bowers, Russell P. Bowler, Jan Bressler, Jennifer A. Brody, Ulrich Broeckel, Jai Broome, Matthew R. Brown, Michael Brown, Brian L. Browning, Sharon R. Browning, Joseph L. Bundy, Esteban G. Burchard, Robert D. Burk, Carlos D. Bustamante, Erin Buth, Javed Butler, Brian E. Cade, Jonathan Cardwell, Vincent J. Carey, Jenna C. Carlson, Cara L. Carty, Richard Casaburi, James F. Casella, Peter J. Castaldi, Mark Chaffin, Jin Choul Chai, Aravinda Chakravarti, Lavanya Challagundla, Nathalie Chami, Kei Hang, Kei Hang Katie Chan, I-Shou Chang, Christy Chang, Yi‐Cheng Chang, Sinéad B. Chapman, Daniel I. Chasman, Sameer Chavan Yii-Der, Ida Chen, Wei‐Min Chen, Zhanghua Chen, Han Chen, Fang Chen, Shu Hui Chen, Ming‐Huei Chen, Chen Ye, Susan Cheng, Yen‐Feng Chiu, Michael Cho, Seung Hoan Choi, Zechen Chong, Jessica X. Chong, Ingrid E. Christophersen, Audrey Y. Chu, Shih‐Kai Chu, Lee‐Ming Chuang, Sung Chun, Jaeyoon Chung, Mina K. Chung, Ren‐Hua Chung, Mina Cintho, Ozahata Mete Civelek, Steven A. Claas, Robert Clark, Shoa L. Clarke, Melina Claussnitzer, Jean R. Clemenceau, Clary B. Clish, Sean Coady, Bradley P. Coe, John W. Cole, Suzy Comhair, Matthew P. Conomos, Brandon J. Coombes, Matthew G. Cordes, Laura Corlin, Elaine Cornell, Adolfo Correa, André Corvelo, Paul Courchesne, Laura Courtney, Carolyn Crandall, James D. Crapo, Damien C. Croteau‐Chonka, Pedro Cruz, L. Adrienne Cupples, Joanne E. Curran, Jeffrey L. Curtis, Brian Custer, Michael J. Cutler, Coleen Damcott, Scott M. Damrauer, Dawood Darbar, Sean P. David, Warwick Daw, Michelle Daya, Mariza de Andrade, Paul S. de Vries, Michael R. DeBaun, Christopher R. deFilippi, Ranjan Deka, Chris Delaney, Tracie DeLuca, Dawn L. DeMeo, Serkalem Demissie, Xutao Deng, Vimal K. Derebail, Pinkal Desai, Anita L. DeStefano, Scott E. Devine, Daniel DiCorpo, Carla Luana Dinardo, Jingzhong Ding, Jun Ding, Jasmin Divers, Avantika R. Diwadkar, Ron Do, HarshaVardhan Doddapaneni, Huawei Dong, Margaret Mengmeng Du, Qing Duan, Shannon Dugan‐Perez, Ravi Duggirala, Josée Dupuis, Jon Peter Durda, Susan K. Dutcher, Charles B. Eaton, Walter L. Eckalbar, Clara S. Ehrman, Evan E. Eichler, Lynette Ekunwe, Adel Boueiz, Jennifer R. Elhawary, Patrick T. Ellinor, Amanda Elliott, Connor A. Emdin, Leslie Emery, Mary J. Emond, Celeste Eng, Serpil C. Erzurum, Tõnu Esko, Luke M. Evans, Shaohua Fan, Fang Fang, Nauder Faraday, Charles R. Farber, David W. Fardo, Candace N. Farmer, Leanna Farnam, Diane Fatkin, Mary F. Feitosa, Adam L. Felsenfeld, Jean Feng, Mike Feolo, Lindsay Fernández‐Rhodes, Nicole M. Ferraro, Jorge Ferrer, Jessica L. Fetterman, Allison Fialkowski, Tasha E. Fingerlin, Annette L. Fitzpatrick, Jonathan M. Flanagan, Jason Flannick, Katherine Fleck, Matthew Flickinger, José C. Florez, James S. Floyd, Bernard Fongang, Marilyn G. Foreman, Myriam Fornage, Cassandra Foster, Caroline S. Fox, Ervin R. Fox, Nora Franceschini, Laurent C. Francioli, Alan J. Franklin, Chris Frazar, Amanda M. Fretts, Yi‐Ping Fu, Mao Fu, Stephanie M. Fullerton, Lucinda A. Fulton, Anna Furniss, Stacey Gabriel, Sarah A. Gagliano Taliun, Daniel Taliun,
De novo mutations (DNMs), or mutations that appear in an individual despite not being seen in their parents, are an important source of genetic variation whose impact is relevant to studies of human evolution, genetics, and disease. Utilizing high-coverage whole-genome sequencing data as part of the Trans-Omics for Precision Medicine (TOPMed) Program, we called 93,325 single-nucleotide DNMs across 1,465 trios from an array of diverse human populations, and used them to directly estimate and analyze ...
National Academy of Sciences
Francesco Perrone, Maria Carmela Piccirillo, Paolo A. Ascierto, Carlo Salvarani, Roberto Parrella, Anna Maria Marata, Patrizia Popoli, Laurenzia Ferraris, Massimiliano M. Marrocco‐Trischitta, Diego Ripamonti, Francesca Binda, Paolo Bonfanti, Nicola Squillace, Francesco Castelli, María Lorenza Muiesan, Miriam Lichtner, Carlo Calzetti, Nicola Duccio Salerno, Luigi Atripaldi, Marco Cascella, Massimo Costantini, Giovanni Dolci, Nicola Facciolongo, Fiorentino Fraganza, Marco Massari, Vincenzo Montesarchio, Cristina Mussini, Emanuele Alberto Negri, Gerardo Botti, Claudia Cardone, Piera Gargiulo, Adriano Gravina, Clorinda Schettino, Laura Arenare, Paolo Chiodini, Ciro Gallo, Francesco Perrone, Maria Carmela Piccirillo, Clorinda Schettino, Adriano Gravina, Piera Gargiulo, Claudia Cardone, Laura Arenare, Paolo A. Ascierto, Maria Grazia Vitale, Claudia Trojaniello, Marco Palla, Attilio Antonio Montano Bianchi, Gerardo Botti, Gianfranco De Feo, Leonardo Miscio, Ciro Gallo, Paolo Chiodini, Laurenzia Ferraris, Massimiliano M. Marrocco‐Trischitta, M. Froldi, Lorenzo Menicanti, Maria Teresa Cuppone, Giulia Gobbo, Chiara Baldessari, Vincenzo Valenti, Serenella Castelvecchio, Federica Poli, Francesca Giacomazzi, Rosangela Piccinni, Maria Laura Annnunziata, Andrea Biondi, Cecilia Bussolari, Manuel Giovanni Mazzoleni, Andrea Giachi, Annalisa Filtz, Arianna Manini, Enrico Poletti, Federico Masserini, Francesco Conforti, Gianfranco Gaudiano, Vittoria Favero, A. Moroni, Tommaso Viva, Fabiana Fancoli, Davide Ferrari, Dario Niro, Marco Resta, Andrea Ballotta, Marco Poli, Marco Ranucci, Diego Ripamonti, Francesca Binda, Alessandra Tebaldi, Giuseppe Gritti, L. Pasulo, Leonardo Gaglio, Roberto Del Fabbro, Leonardo Alborghetti, Paolo Bonfanti, Nicola Squillace, Giulia Giustinetti, Paola Columpsi, Marina Elena Cazzaniga, Serena Capici, Luca Sala, Riccardo Di Sciacca, Giacomo Mosca, Maria Rosa Pirozzi, Francesco Castelli, María Lorenza Muiesan, Franco Franceschini, Aldo M. Roccaro, Massimo Salvetti, Anna Paini, Luciano Corda, Chiara Ricci, Lina Rachele Tomasoni, Paola Nasta, Silvia Lorenzotti, Silvia Odolini, Emanuele Focà, Eugenia Quirós-Roldán, Marco Metra, Stefano Maria Magrini, Paolo Borghetti, Nicola Latronico, Simone Piva, Matteo Filippini, Francesco Zuccalà, Sergio Cattaneo, Francesco Scolari, Nicola Bossini, Mario Gaggiotti, Martina Properzi, Miriam Lichtner, Cosmo Del Borgo, Raffaella Marocco, Valeria Belvisi, Tiziana Tieghi, Margherita De Masi, Paola Zuccalà, Paolo Fabietti, Angelo Vetica, V. S. Mercurio, Anna Carraro, Laura Fondaco, Blerta Kertusha, Ambrogio Curtolo, Emanuela Del Giudice, Riccardo Lubrano, Maria Gioconda Zotti, Antonella Puorto, Marcello Ciuffreda, Antonella Sarni, Gabriella Monteforte, Domenico M. Romeo, Emanuela Viola, C. Damiani, Antonietta Barone, Barbara Mantovani, Daniela Di Sanzo, Vincenzo Gentili, Massimo Carletti, Massimo Aiuti, Andrea Gallo, Piero Giuseppe Meliante, Salvatore Martellucci, Oliviero Riggio, Vincenzo Cardinale, Lorenzo Ridola, Maria Consiglia Bragazzi, Stefania Gioia, Emiliano Valenzi, Camilla Graziosi, Niccolò Bina, Martina Fasolo, Silvano Ricci, Maria Teresa Gioacchini, Antonella Lucci, Luisella Corso, Daniela Tornese, Parni Nijhawan, Francesco Equitani, Carmine Cosentino, Marcello Palladino, Frida Leonetti, Gaetano Leto, Camillo Gnessi, Giuseppe Campagna, Roberto Cesareo, Francesca Marrocco, Giuseppe Straface, Alessandra Mecozzi, Lidia Di Cerbo, Valentina Isgrò, Sergio Parrocchia, Giuseppe Visconti, Giorgio Casati, Carlo Calzetti, Alarico Ariani, Lorenzo Donghi, Nicola Duccio Salerno, Evelina Tacconelli, M. Bertoldi, Paolo Cattaneo, Lorenza Lambertenghi, Leonardo Pereira Motta, Luca Omega, Giovanni Albano, Roberto Parrella, Fiorentino Fraganza, Luigi Atripaldi, Vincenzo Montesarchio, Francesco Scarano, Annunziata De Rosa, Amalia Buglione, Sabrina Lavoretano, Gianfranco Gaglione, Mario De Marco, Vincenzo Sangiovanni, Francesco Maria Fusco, Rosaria Viglietti, Elio Manzillo, Carolina Rescigno, Raffaella Pisapia, Giulia Plamieri, Alberto Enrico Maraolo, Giosuè Calabria, Mario Catalano, Giuseppe Fiorentino, Anna Annunziata, Giorgio Emanuele Polistina, Pasquale Imitazione, Mariano Mollica, Vincenzo Esposito, Maurizio D’Abraccio, Rodolfo Punzi, Vincenzo Bianco, Costanza Sbreglia, Rosa Fontana Del Vecchio, Alessandro Bordonali, Antonina Franco, Carlo Salvarani, Marco Massari, Giovanni Dolci, Pierpaolo Salsi, Giuseppe Virzì, Ornella Calderone, Alfredo Molteni, Silvia Gennarini, Umberto Gnudi, Maria Anastasia Ricci, Giancarlo Titolo, Giulio Mensi, Pietro Vuotto, Beatrice Gasperini, Mauro Mancini, Zeno Pasquini, P. Spanu, Stefano Clementi, Simona Pierini, Daniela Bokor, Davide Gori, Morena Ciofetti, Marina Caimi, L. Bettazzi, E. Allevi, Silvia Furiani, Chiara Capitanio, Bernardino Mastropasqua, Claudio Fara, Grazia Pulitanò, Jun Matsuno, Francesca Porta, Viola Dolfini, Nebiat Balei Beyene, Michela Bezzi, Mauro Novali, Pierluigi Viale, Sara Tedeschi, Renato Pascale, Raffaele Bruno, Di Filippo A, Michele Sachs, Tiberio Oggionni, M. Di Stefano, Caterina Mengoli, Cesarina Facchini, De Nardo Daniele, Gabriele Frausini, Luciano Mucci, Silvia Tedesco, Rita Girolimetti, Elena Manfredini, Anna Maria Di Carlo, Emma Espinosa, Donatella Dennetta, Andrea Ticinesi, Tiziana Meschi, Antonio Nouvenne,
Abstract Background Tocilizumab blocks pro-inflammatory activity of interleukin-6 (IL-6), involved in pathogenesis of pneumonia the most frequent cause of death in COVID-19 patients. Methods A multicenter, single-arm, hypothesis-driven trial was planned, according to a phase 2 design, to study the effect of tocilizumab on lethality rates at 14 and 30 days (co-primary endpoints, a priori expected rates being 20 and 35%, respectively). A further prospective cohort of patients, consecutively enrolled ...
BioMed Central
Andrew Sih, James J. Krupa, Steven E. Travers,
... L Russell, Stephen L Buchmann, William de O Sabino, Daniel R Papaj Brawls Bring Buzz: Male Size ...
Tópico(s): Animal Behavior and Reproduction
1990 - University of Chicago Press | The American Naturalist