Photograph of the cenotaphs of the Orchha Rajas on the Betwa River at Orchha, from an Album of Miscellaneous views in India, taken by Deen Dayal, c.1882. ...
0000 - Gale Group | NCCO Photography
Erika Shor, Christopher L. Warren, Joshua R. Tietjen, Zhonggang Hou, Ulrika Müller, Ilaria Alborelli, Florence H. Gohard, Adrian I. Yemm, Lev Borisov, James R. Broach, Michael Weinreich, Conrad A. Nieduszynski, Aseem Z. Ansari, Catherine A. Fox,
The origin recognition complex (ORC) marks chromosomal sites as replication origins and is essential for replication initiation. In yeast, ORC also binds to DNA elements called silencers, where ... have led to a model proposing that when ORC becomes limiting in the cell (such as in the orc2-1 mutant) only sites that bind ORC tightly (such as HMR-E) remain fully occupied by ORC, while lower affinity sites, including many origins, lose ORC occupancy. Since HMR-E possessed a unique non- ... other tight sites might reveal novel functions for ORC on chromosomes. Therefore, we comprehensively determined ORC "affinity" ...
Tópico(s): Genetic Neurodegenerative Diseases
2009 - Public Library of Science | PLoS Genetics
Srikumar Sen, Boxing Correspondent, Philip Schofield, Jon Ashworth, N. W. P. Cole, John White, Tim Judah and our Foreign Staff, Patricia Davies, Richard Ford, Home Correspondent, John O'leary Education Correspondent, Victor Serebriakoff (Chairman), Jill Sherman Political Correspondent, Bill Frost, Neil Bennett, Peter Briffa, Rachel Kelly and Douglas Broom, John Diamond, Debra Enderby, Alan Hamilton and Philip Jacobson, Angela MacKay, Ross Tieman, Industrial Correspondent, Peter H. Gillard, Philip Howard, Matthew D'Ancona, Ian Murray, Jeremy Kingston, James Bone, Martin Barthoud, Melinda Wittstock, Media Correspondent, Carol Leonard, Harry Eyres, Terry Landsbert (Secretary), Richard Eaton, Kevin Eason, Motoring Correspondent, Stuart Jones Football Correspondent, Neil Bennett, Banking Correspondent, Prince Rostislav Romanov, Simon Wilde, Geoff Brown, Michael Tate, City Editor, Joe Joseph, Bernard Levin, Martin ROGERS(Co-ordinator), Martin Fletcher, R. S. Musgrave, Duncan Alexander, Mitchell Platts, Golf Correspondent, Andrew Longmore Tennis Correspondent, Nicholas Wood Political Correspondent, Peter Stothard, US Editor, Peter Ball, Roger Tanner, Matthew d'Ancona and Ray Clancy, M. Pugsley, Alpa Raja, Louise Taylor, Martin Barrow, Douglas Broom, Michael Evans, Defence Correspondent, Richard Ford Home Correspondent, Alan Hamilton, V. S. Anthony, Secretary, John F. Martin, Rodney Milnes, R. W. Lund, Louise Hidalgo, Jenny MacArthur, Rachel Kelly, Property Correspondent, Robert Bruce, Angela Gallop, Philip Pangalos and Colin Narbrough, A. H. Stephenson, Andrew Colquhoun, Woodrow Wyatt, Philip Dinkel, S. Kukowski, Edward Fennell, Michael McCarthy Environment Correspondent, Lindsay Cook Money Editor, Melinda Wittstock Media Correspondent, David Miller, Robin Oakley Political Editor, Geoffrey Kemp, Barry Millington, Alison Roberts, Wolfgang Münchau, Simon Heffer, Harvey Elliott Travel Correspondent, Robin Oakley, Political Editor, Hilda Wilson, David Robinson, Alan Lee, Cricket Correspondent, Lois Rathbone, Lesley Chamberlain, Raymond Keene, Chess Correspondent, Craig Brown, Michael McCarthy, Environment Correspondent and James Bone, Paul Wilkinson, Ali Jaber, Peter Stothard, Joseph J. Nunan, Richard Evans, Nigel Hawkes, Michael Wright, Charles Warren, Clive Candy, Jeremy Hornsby (Chairman of Billiards), David Powell, Athletics Correspondent, Roger Boyes, Ronald Butt, Colin Campbell, Mining Correspondent, Christopher Thomas, Joanna Pitman, John Goodbody, Philip Webster Chief Political Correspondent, Sara McConnell, Henry Chadwick, Ross Tieman Industrial Correspondent, Tom Stacey, Malcolm Hardwick, Jo Stanley, Matthew Parris, Graham Searjeant Financial Editor, Clive White, Richard Evans Racing Correspondent, Sheila Gunn Political Correspondent, Simon Callow, Alan Lee, Mark Hannen, Peter Riddell, Alan Lee Cricket Correspondent, Michael Phillips, David Sinclair, Philip Pangalos, Russell Stockdale, Martin Waller, Ross Midgley, Colin Clifford, Derek Harris, Keith Waterhouse, Deirdre Edington, Frances Gibb, Ronald Paux, Beverley Shaw, John Phillips, Alan Jackson, I. D. Thurston, Matthew Bond, J. R. Stephenson, Secretary, Colin Campbell, John O'leary, Education Correspondent, Philip Jacobson, David Hands, Rugby Correspondent, John Munkman, Richard Ford, Andrew Longmore, Tennis Correspondent, John Watson,
... Bowers Country Landowners Association Multiple Display Advertising Items ORC European Information Centre Limited Multiple Display Advertising Items ... insecurity General Appointments Fimbra The British Museum Society ORC European Information Centre Limited Grampian Regional Council Dp ...
1992 - Gale Group | TDA
Pieter S. Stepaniak, Guido H. H. Mannaerts, Marcel de Quelerij, Guus de Vries,
The Operating Room Coordinator (ORC) is responsible for filling gaps in every operating room (OR) schedule. We have observed differences among the personalities of the four ORCs with regard to their willingness to agree to ... between the personality of each of the four ORCs and the risk an ORC is willing to take of cases running late ... In order to judge the personality of an ORC in relation to risk-taking in planning schedules, ... study. Seven anesthesiologists were asked to score every ORC on willingness to take risks in planning. To ...
Tópico(s): Patient Safety and Medication Errors
2009 - Lippincott Williams & Wilkins | Anesthesia & Analgesia
David Henshaw, Rosalind Mitchison, Jane James, John Mellors, Derek Robinson, Mervyn Jones, D. A. N. Jones, Roy Hattersley, Mabel Baker, Stephen Woodley, Rod Caird, Patricia Beer, Robert Foxcroft, Richard Combs, Enid R. Woollett, Edward Wates, E. S. Turner, Charles Freeman, Hilary Corke, Hyam Maccoby, Arthur Peacock, Russell Davies, Peter Reddaway, Gregory Macdonald, Milton Friedman, John Simpson, C. J. Bilton, P. N. Furbank, Anthony Howard, Andro Linklater, Enid Lakeman, E. M. Holroyd, John Elsom, Jack Pizzey, P. W. Selbourne, B. P. Scanlan, Alan Watkins,
... of the surveys carried out by Mafs and ORC Mister Knox-Richards Ltd. BBC Publications 50 Years ...
1980 - Gale Group | The Listener GDA
Taraka Donti, Shibani Datta, Pamela Y. Sandoval, Geoffrey M. Kapler,
Article15 January 2009free access Differential targeting of Tetrahymena ORC to ribosomal DNA and non-rDNA replication origins ... Figures & Info The Tetrahymena thermophila origin recognition complex (ORC) contains an integral RNA subunit, 26T RNA, which ... and hence complementarity to 26T RNA, suggesting that ORC is recruited to these sites by an RNA-independent mechanism. Consistent with this prediction, although ORC associated exclusively with origin sequences in the 21 kb rDNA minichromosome, the interaction between ORC and the non-rDNA ARS1 chromosome changed across ...
Tópico(s): Acute Lymphoblastic Leukemia research
2009 - Springer Nature | The EMBO Journal
From Harry Debelius, By Fred Emery Political Editor, By Andrew Goodrick-Clarke Financial Editor, From Anthony Hilton, By Our Diplomatic Correspondent, By Paul Routledge Labour Editor, Ex David Felton Labour Reporter, By Our Labour Staff, By Our Health Services Correspondent, By Donald Macintyre Labour Reporter, By Frances Gibb, By Diana Geddes, By George Clark Political Correspondent, By Pat Healy Social Services Correspondent, By Our Education Correspondent, By Ian Bradley, By Lucy Hodges, By Michael Baily Transport Correspondent, By Peter Hennessy, By Peter Evans Home Affairs Correspondent, By Our Home Affairs Correspondent, By A Staff Reporter, By Kenneth Gosling Arts Reporter, By a Staff Reporter, By Clifford Longley Religious Affairs Correspondent, By Our Religious Affairs Correspondent, From Christopher Warman Local Government Correspondent, From Ian Murray, From Our Own Correspondent, From Jose Shercliff, From Robert Schuil, From Denis Reinhardt, From Our Correspondent, From Nicholas Ashford, From Dessa Trevisan, From Michael Leapman, From David Watts, From Peter Hazelhurst, From Christopher Walker, From Ivor Davis, From John Young, From Stephen Downer, From Richard Streeton, By Jim Railton, By Keith Macklin, By Rex Bellamy Tennis Correspondent, By John Woodcock Cricket Correspondent, By Pamela Macgregor-Morris, By John Nicholls, By Michael Phillips Racing Correspondent, John Russell Taylor, Max Harrison, Richard Williams, Michael Church, Ned Chaillet, John Percival, Ronald Butt, Bernard Levin, Roger Berthoud, Marcel Berlins Legal Correspondent, A. BLYGHTON, Pearl Venit, WALTER GOLDSMITH, , R. H. SCHURINK, , GLANVILLE WILLIAMS, , DUNCAN WILSON, D. R. THORPE., FRANK ALLAUN, , HARRY KANTER, , JILL MARTIN, , PHILIP EVANS, , L. S. PRESSNELL, , MAX BELOFF, , Rosemary Brown, Shona Crawford Poole, By Norman Hammond Archeology Correspondent, By Geraldine Norman Sale Room Correspondent, By Pearce Wright Science Editor, A correspondent, Mr R. W. M. Rees and Mr D. G., Morris, A Correspondent, Michael Ratcliffe, Richard Holmes, Peter Tinniswood, Jo Grimond, Basil Boothroyd, By Ronald Pullen, By Our Financial Staff, By Patricia Tisdall Management Correspondent, By Roman Eisenstein Banking Correspondent, By Philip Robinson, David Hewsom, By Nicholas Hirst Energy Correspondent, By John Huxley, By Caroline Atkinson, By Our Energy Correspondent, Edward Townsend, From Frank Vogl United States Economics Correspondent, From Kenneth Owen, J. B. HOLGATE, , J. STANSBY, , R. H. RANSFORD., J. F. MARTIN., LEO KENNEDY., PHILIP H. STUNT., BY THE FINANCIAL EDITOR, Ross Davies, Caroline Atkinson, Hugh Stephenson, By Rosemary Unsworth, By Peter Wainwright, By Catherine Gunn, Michael Prest Mining Correspondent, By Michael Prest, Edited by Peter Davalle,
... weigh up Mr Manley's coup, The Times/ORC Poll Improving family life is main motivation for ...
1980 - Gale Group | TDA
Heather K. MacAlpine, Raluca Gordân, Sara Powell, Alexander J. Hartemink, David M. MacAlpine,
The origin recognition complex (ORC) is an essential DNA replication initiation factor conserved in all eukaryotes. In Saccharomyces cerevisiae, ORC binds to specific DNA elements; however, in higher eukaryotes, ORC exhibits little sequence specificity in vitro or in vivo. We investigated the genome-wide distribution of ORC in Drosophila and found that ORC localizes to specific chromosomal locations in the absence ... use machine learning approaches to accurately discriminate between ORC-associated sequences and ORC-free sequences based solely ...
Tópico(s): RNA Research and Splicing
2009 - Cold Spring Harbor Laboratory Press | Genome Research
Giles Smith, Richard Mabey, Andrew Robson, Janice Turner, Christina Hardyment, John McNamara, Jon Ashworth, Cath Urquhart, David Adams, Richard Whitehead, Mousse, Benedict Cottrell Boyce, Nigel Colborn, Adam Sherwin Media Reporter, Dr Thomas Stuttaford and Suzi Godson, Jane MacQuitty, Simon Barnes, Jasper Rees, Magnus Linklater, Paul Hoggart, Tom Gard, Richard Hobson, Stephen D. Rountree (President and Chief Executive Officer), Ivo Tennant, Clare Lazaro, Olivia Lichtenstein, William Starling, Tony Turnbull, Philip Howard, Mykel Nicolaou, Hannah Betts, Carol Midgley, Shobna Gulati, Christine Seib, Tara Holmes, David Chater, Kenneth Stern (Chairman), Suna Erdem, James Bone, Rachel Campbell-Johnston, Dominic Wells, Nic Hopkins, Mom Rock, Clive Davis, Laura Peek, Rob Garrett and Kate Nevens, John Kenny, Elizabeth Judge, Gabrielle Starkey, Lucia Van Der Post, Ian Kelly, Iraq Burhan Wazir, Wendy Ide, Tristram Hunt, John Bungey, Kevin Eason, Angela Lindvall, Geoff Brown, Philippe Naughton, Clare Stewart, Pauline McLeod, Giles Coren, David Sharrock, Antonia Senior, Peter Draper (Director), Christine Lamb, Sir Roger Moore, Nancy Durrant, John Clarke, Howard Davies, Valerie Elliott, Rob Cassy, Mariella Frostrup, Katherine Swift, Steve Bird, July Skies, Jeremy Irons, Ruth Jamieson, Allan Simmons, Natasha Bedingfield, Dr Jane Collins, Tim Reid, Daniel Finkelstein, Angela Jameson Industrial Correspondent, Jeanette Winterson, Ruth Gledhill Religion Correspondent, Jane Clarke, MM, Tom Gatti, Candida Crewe, Jo Morris, Nick Robinson, Alan Hamilton, Peter Millar, Theresa May, Steve Harries, Denis Richmond, Steven Thomson, Mark Gatiss, Valerie Elliott Consumer Editor, Peter Newble, Roland Watson, Daisy Goodwin, David Hands, Tina Gaudoin, Charles Bremner, Richard Johnson, Ian MacKinnon, Ron Lewis, Stefanie Marsh, Sarah Tucker, Genevieve Fox, David Charter, Tim Teeman, Nigella Lawson, Derwent May, Sir Trevor McDonald, Angela Jameson, Harriet O'Brien, Ivan Hewett, John Mendelsohn, John Lawrence, Russell Kempson, Paula Hawkins, Timely Gifts, Peter Paphides, Adrian Woolfson, David Rowan, Dan Silver, Tony Halpin Education Editor, Richard Cork, Oliver Kay, Ed Potton, Nigel Williamson, Emanuele Paladino, Stephen Anderton, Amber Cowan, Lisa Grainger, Antony Bye, Mark Atherton, John Westerby, Lisa Armstrong, Rick Broadbent, Patrick Hosking Investment Editor, Tom Baldwin, Sam Coates, Chris Power, Dr Feelgood, Philip Webster and Peter Riddell, Murray Boldt, Credo Jonathan Sacks, Simon de Bruxelles, John Hopkins Golf Correspondent, Rob Wright, Marisa Leaf (Legal Officer), Celia Brayfield, Sheila Hancock, Magnus Grimond, Sarah Turner, Stuart Miles, Gabriel Rozenberg, Benjamin Fry, Jack Nicholson, Raymond Keene, Joanna Lumley, Adam Sage, Suzi Godson, Lewis Smith, Matthew Pryor, Alan Filmer, Matt Dickinson, Richard Brass, Fiona Morrow, Gordon Ramsay, Peter Stothard, Paul Levy, Michael Poole, Royal Doulton, Richard Dixon, Kaveh Solhekol, Jeremy Page, Clare Longrigg, Chris Campling, Ellin Stein, Edwin Booth, Patrick Hosking, Richard Owen, Christopher Martin-Jenkins Chief Cricket Correspondent, Alex Hawkes, Erica Wagner, Marcel Berlins, Jeremy Paxman, Susie Amy, Bridget Chapple Table Talk, Barry Shooter, Chloë Bryan-Brown, James Naughtie, Moira Lavery Callaghan, Graham Searjeant Personal Investor, Bill Bryson, David Hands Rugby Correspondent, Tom Dart, Victoria O'brien, Julian Muscat, Paul Simons, Robin Lane Fox, Adam Fresco, Chris Condron, Anna Frame, Marie Tourres and Elsa Brely, Michelle Henery, Sam Mcknight, Anne Ashworth, John Goodbody, Dominic Kennedy, Santa Myth, Joanna Pitman, James Doran, Tom Cox, Nigel Kendall, Mark Morris, Leo Lewis and Ben Hoyle, Robert Crampton, Jane Shilling, Craig Lord, Julie Burchill, Matthew Parris, Graham Searjeant Financial Editor, Adrian Edmondson, Anjana Ahuja, Amanda Craig, Jonathan Rendall, Tim Wapshott, Russell Jenkins, Caitlin Moran, Sheila Keating, Rebecca Ley, Hugh Fearnley-Whittingstall, Iain Finlayson, Anthony Loyd, Peter Riddell, Ben MacIntyre, Antony Beevor, Brian Glanville, David James, John Carey, Alison Gibson, John Naish, Anne Ashworth Personal Finance Editor, Annabelle Thorpe, Catherine Philp, Martin Waller, Michael Horsnell, Chris Ayres, Frank Gehry (Architect), Kate Quill, Richard Thompson (Solicitor), Sarah Butler, Darian Leader, Oliver Kamm, Benedict Nightingale, Dalya Alberg and Sean O'Neill, Valerie Elliott and Shirley English, Jonathan Meades, Stephen Dalton, Jill Crawshaw, Anna-Marie Crowhurst, Alyson Rudd, Paul Connolly, Tom Chesshyre, James Christopher, Fred Dellar, Abigail Rayner, Simon Crompton, Alan Lee Racing Correspondent, Sebastian Smith, Owen Slot, Cath Urquhart Travel Editor, Louise Hancock, Douglas Kennedy, Daphne Lockyer, Colin Rafferty, Clare Simmons, Richard Ford, Peter Klinger, Patience Wheatcroft, Joe Bolger, Lisa Verrico, Irma Kurtz, Bad Santa, Stephen Pollard,
... for Middle-Earth Game Reviews Go hunt some orc with The Battle for Middle-earth The Moment ...
2004 - Gale Group | TDA
... the poor thermal efficiency of organic Rankine cycles (ORC). A novel idea is proposed where a vapour ... chiller (VAC) can be employed to lower the ORC condensing temperature, thus increasing its power output. This ... extract heat from the geothermal brine leaving the ORC vaporizer. The evaporator of the VAC serves as the ORC condenser. A computer program is coded to simulate the combined ORC-VAC performance and compare it with that of the conventional ORC. The results indicate that the ORC-VAC option would render power generation more economical. ...
Tópico(s): Thermal Radiation and Cooling Technologies
1992 - Elsevier BV | Heat Recovery Systems and CHP
By David Wood Political Editor, By a Staff Reporter, By Peter Hennessy, By Malcolm Brown, From Dan van der Vat, By Our Political Correspondent, By Raymond Perman Labour Staff, By Paul Routledge Labour Editor, From Robert Fisk, From Our Correspondent, By Our Legal Correspondent, By Marcel Berlins Legal Correspondent, By Tim Devlin Education Correspondent, By Our Political Staff, Hugh Clayton, By Pearce Wright Science Correspondent, From Hugh Noyes, From Geoffrey Browning, From Christopher Walker, From Peter Evans, From John Winder, By George Clark Political Correspondent, Philip Howard, From Christopher Warman, By Nicholas Ashford, From Our Own Correspondent, From Richard Wigg, From Patrick Brogan, From Fred Emery, From Michael Hornsby, From Mario Modiano, From Paul Martin, European Parliament Luxembourg, David Robinson, Stanley Sadie, John Percival, Paul Griffiths, Alan Coren, Charles Lewsen, By Rex Bellamy Tennis Correspondent, By Pamela MacGregor-Morris, By Peter West Rugby Correspondent, By John Blunsden, By John Woodcock Cricket Correspondent, By Neil Allen Athletics Correspondent, By Norman Fox, By Joyce Whitehead, By Michael Phillips Racing Correspondent, Geoffrey Parkinson, John Maddox, Henry Stanhope Defence Correspondent, PHS, Ronald Faux, PAUL SIEGHART, , DAVID GREEN, , ROLAND MOYLE, Minister of State for Northern Ireland, House of Commons, September 25., GHITA JONESCU., RUTH JONES., CHRIS MILLER., CHRISTOPHER JAMES., F. R. ALTHAUS, PHILIP NIMAN, , ROY PLOMLEY, , P. L. SHINNIE, , STUART ANDREWS, , BARNES WALLIS, , BARBARA DYER, , H. G. LEVENTHALL, , CLARE HAWKINS, , From Frank Vogl, From Our United States Economics Correspondent, By R. W. Shakespeare., By Maurice Corina Industrial Editor, By Christopher Wilkins, By Malcom Brown, From Kenneth Owen, By Peter Hill, By Our Industrial Editor, By Tim Congdon, W. B. HEMINGWAY., M. K. ATKINS., C. J. THOMAS, , R. Y. HOLDSWORTH, , BY THE FINANCIAL EDITOR, by Margaret Stone, by Vera Di Palma, M.S., by Toby Everitt, J.G., by Gerald Reitlinger, by John Gaselee, by Barbara Conway,
... Mr Rockefeller by denouncing him over jail killings, ORC poll shows that voters are ignorant of the ...
1974 - Gale Group | TDA
Christian Keller, Eva‐Maria Ladenburger, Marcel Kremer, Rolf Knippers,
The locations of the origin recognition complex (ORC) in mammalian genomes have been elusive. We have therefore analyzed the DNA sequences associated with human ORC via in vivo cross-linking and chromatin immunoprecipitation. ... protein precipitate chromatin fragments that also contain other ORC proteins, suggesting that the proteins form multisubunit complexes on chromatin in vivo. A binding region for ORC was identified at the CpG island upstream of ... gene. Nascent strand abundance assays show that the ORC binding region coincides with an origin of bidirectional ...
Tópico(s): Chromosomal and Genetic Variations
2002 - Elsevier BV | Journal of Biological Chemistry
From John Hennessy, From Robert Fisk, By Our Labour Editor, By Paul Routledge Labour Editor, From Dessa Trevisan, By Stewart Tendler, From Christopher Walker, By Michael Baily Shipping Correspondent, By David Felton Labour Reporter, By Ian Bradley, By Frances Gibb, By Marcel Berlins Legal Correspondent, By Michael Hatfield Political Reporter, By Our Political Reporter, By Peter Hill Industrial Editor, By Christopher Warman Local Government Correspondent, By Peter Evans Home Affairs Correspondent, By Pat Healy Social Services Correspondent, By Craig Seton, By a Staff Reporter, From Our Correspondent, By Pearce Wright Science Editor, By Kenneth Gosling Arts Reporter, By Martin Huckerby Music Reporter, From Harry Debelius, From Charles Hargrove, From Our Own Correspondent, From Nicholas Ashford, From Eric Marsden, From Ian Murray, From Michael Binyon, By Henry Stanhope Defence Correspondent, From David Cross, From Patrick Brogan, From Neil Kelly, From Jean-Pierre Gallois, From Richard Hughes, From Ivor Davis, From John Woodcock Cricket Correspondent, By Sydney Friskin, By Peter West Rugby Correspondent, By Norman Fox Football Correspondent, From Peter Ryde, By Michael Seely, By Keith Macklin, John Russell Taylor, Kenneth Loveland, Paul Griffiths, William Mann, Joan Chissell, Noel Goodwin, Stanley Sadie, Barry Millington, John Percival, Michael Leapman, Philip Howard, David Wood, WILLIAM HAYTER, , MICHAEL OGDEN, , NEVILLE MARCH HUNNINGS, , DAVID SNEATH, , JEREMY MITCHELL, , JEAN WILSON, , PETER MASEFIELD, , DAVID LANE, , ALFRED A. WOOD, , ROY A. GRANTHAM, , PETER LISTER, , ROY SOUTHWELL, , MIKE ST AUBYN, , By Clifford Longley, From Clive Cookson of The, Leonard Amey, By Harry Golombek Chess Correspondent, H. F. writes:, F. H. H. writes:, E. L. writes, S. S. T. writes:, By Edward Townsend, By Margaret Stone, Frank Vogl, By Andrew Goodrick-Clarke Financial Editor, From Anthony Hilton, By Clifford Webb, By Nicholas Hirst Energy Correspondent, By John Huxley, BY THE FINANCIAL EDITOR, Arthur Reed, John Whitmore, Ronald Faux, Ronald Kershaw, Patricia Tisdall, Michael Clark, Michael Prest, Adrienne Gleeson, W. H. FULTON, , JAMES LIPSCOMBE, , F. G. HOLLAND, , BERNARD WOOD, , B. A. LIGHT, , Peter Wainwright, David Robinson, Wallace Jackson Commodities Editor, Gerald Ely, Edited by Peter Davalle,
... GLC, Mr Nkomo seen as the unifying politician, Orc A sweeping disapproval of flying pickets, Seamen's ...
1980 - Gale Group | TDA
John F.X. Diffley, Karim Labib,
... binding of the six subunit origin recognition complex (ORC), which has been conserved in evolution from yeast to humans. In budding yeast, ORC binds specifically to an essential, bipartite sequence element within replication origins. ORC binds ATP and this binding is required for DNA binding. ORC can also hydrolyse ATP; however, ATP hydrolysis is ... and is, in fact, inhibited upon origin binding. ORC remains bound to origins throughout the cell cycle ... yeast, even through mitosis. In multicellular eukaryotes some ORC subunits remain bound throughout G1, S and G2 ...
Tópico(s): Genomics and Chromatin Dynamics
2002 - The Company of Biologists | Journal of Cell Science
From David Blake and Peter Norman, From Harry Debelius, From Michael Hornsby, By Donald Macintyre Labour Reporter, From Trevor Fishlock, From Our Correspondent, From Ian Murray, From Paul Routledge Labour Editor, By Our Political Reporter, By Our Labour Editor, By Michael Hatfield Political Reporter, By Peter Hennessy, By Christopher Thomas, By Our Motoring Correspondent, By Christopher Warman Local Government Correspondent, By Diana Geddes Education Correspondent, By Annabel Ferriman Health Services Correspondent, By Our Health Services Correspondent, By Norman Hammond Archaeology Correspondent, By Lucy Hodges, By John Huxley, By John Chartres, By Peter Waymark, By Hugh Clayton Agriculture Correspondent, From Gretel Spitzer, From Our Own Correspondent, From John Earle, From Tewfik Mishlawi, From Charles Harrison, By Caroline Moorehead, From Peter Hazelhurst, From Jacqueline Reditt, From Michael Leapman, Ned Chaillet, Paul Griffiths, Max Harrison, Judith Nagley, John Percival, William Mann, Andrew Sinclair, By John Woodcock Cricket Correspondent, From Richard Streeton, By Peter Ryde, From Norman Fox Football Correspondent, By Rex Bellamy Tennis Correspondent, By Pamela Macgregor-Morris, By Our Rifle Shooting Correspondent, By Iain Mackenzie, By Michael Phillips Racing Correspondent, By the Staff of Nature, Gerald Ely, Philip Howard, Michael Leapman, John Grant, David Spanier Diplomatic Correspondent, David Wood, W. B. JOHNSTON, IAIN O. MACDONALD, , HUMPHRY BERKELEY, , PHILLIPS, , FRANK HELLNER, , W. H. LEVY, , JOHN LYONS, , JEREMY ROWE, , TITO BENADY, , J. DOMINIAN, , ROGER CLEGG, , JOHN F. A. WILLIAMS, , MALCOLM JOHNSON, , By Clifford Longley Religious Affairs Correspondent, Hugh Clayton, By Geraldine Norman Sale Room Correspondent, Lady Bawden, Henry Stanhope Defence Correspondent, Christopher Thomas, Henry Stanhope, Derek Harris Commercial Editor, Patrick O'Leary, E. P. Thompson, Pearce Wright Science Editor, H.S., Arthur Reed Air Correspondent, A.R., Pearce Wright, P.W., By Nicholas Hirst Energy Correspondent, Frank Vogl, By Patricia Tisdall Management Correspondent, From Frank Vogl U.S. Economics Correspondent, By John Whitmore Financial Correspondent, By Peter Hill, By Bill Johnstone, Derek Harris, Sydney Paulden, Jan van der Beek, Michael Webb-Bowen, ALLAN THORNTON, , I. H. F. FINDLAY, , G. H. BLAKE, , A. P. M. MYERS, , P. J. R. SPIRA, , SIMON GRAY, , KENNETH REID, , BY THE FINANCIAL EDITOR, Ross Davies, Andrew Goodrick-Clarke, James Mead, By Peter Wilson-Smith, Michael Clark, Rosemary Unsworth, John McIlwraith, Michael Prest Commodities Correspondent, David Robinson, By Our Financial Staff, Edited by Peter Dear,
... start talk of a new Watergate, The Times/ORC Poll The erosion of our will to work ...
1980 - Gale Group | TDA
Ray-Yuan Chuang, Louise Chrétien, Jianli Dai, Thomas J. Kelly,
The origin recognition complex (ORC) plays a central role in the initiation of DNA replication in eukaryotic cells. It interacts with origins of DNA replication ... level except in the case of Saccharomyces cerevisiae ORC. We report here the expression, purification, and initial ... reaction with purified proteins. The origin recognition complex (ORC) plays a central role in the initiation of ... level except in the case of Saccharomyces cerevisiae ORC. We report here the expression, purification, and initial ...
Tópico(s): Microtubule and mitosis dynamics
2002 - Elsevier BV | Journal of Biological Chemistry
Srikumar Sen, Boxing Correspondent, Nicholas Ross, Victoria McKee, Garry Humphreys, Frances Gibb, Legal Affairs Correspondent, Nicholas Wood, Political Correspondent, Sara Baverstock, Patricia Davies, Mike Lamb, Simon Barnes, Jasper Rees, Laszlo Kiss, David Miller Chief Sports Correspondent, Cellan Williams, Mark Souster, Ronald Faux, David Lowry, Director, Sheridan Morley, B. W. Beckett, Angela MacKay, Michael Stevenson, Philip Howard, Tom Giles, Ian Murray, Michael Binyon, Harvey Elliott and Lin Jenkins, Howard William, Melinda Wittstock, Media Correspondent, Liz Hodgkinson, Carol Leonard, Mandarin (Michael Phillips), V. M., Albert Dormer, Richard Streeton, Stuart Jones Football Correspondent, Stewart Tendler, Crime Correspondent, Roddy Forsyth, Colin Narbrough Economics Correspondent, Jane Elliott, Joe Joseph, Martin Fletcher, Tim Jones, Employment Correspondent, Michael Tate, P. I. Packwood, David Haslam, Mohamed Heikal, Ruth Gledhill, Peter Ball, Roger Walkinton, R. S. Byram, Raymond Keene Chess Correspondent, Louise Taylor, Lawrence James, Matin Fletcher, David Tytler Education Editor, Elaine Fogg, Michael Clark, H. J. Baker, Henry Lawson-Tancred, Kevin Eason Motoring Correspondent, Charles Bremner, John Percival, John Hennessy, Wolfgang MüNCHAU European Business Correspondent, Roddy MacKenzie, Harvey Elliott, Air Correspondent, Andrew Gibbon Williams, Gavin Bell, Sydney Friskin, A. M. Jones, Robin Oakley Political Editor, Martin Jacques, John Higgins, Kerry Gill, Jonathan Prynn, Alan Lee, Cricket Correspondent, Nicholas Beeston, M. W. S. Hitchcock, Craig Brown, Peter Stothard, Steve Acteson, Ruth Gledhill, Religious Affairs Reporter, Alan Ryan, Richard Evans, Peter Dear and Gillian Maxey, Barry Pickthall, Ian Ross, John O'leary, Higher Education Correspondent, Michael Hornsby, Agriculture Correspondent, Simon Tait, Arts Correspondent, David Brewerton, Christopher Thomas, John Goodbody, Jane Bidder, Christopher Walker, Alan Tillier, Clive White, Michael Hartnack, I. Lyenn Evans, Thomson Prentice, Medical Correspondent, Peter Victor, Michael Knipe, Diplomatic Correspondent, Arthur Leathley and Michael Evans, Philip Webster and Michael Evans, Melinda Wittstock, Michael Horsnell, Benedict Nightingale, David Powell, Steve Turner, Derek Harris Industrial Editor, Anne McElvoy, Michael Evans, Charles Mathiesen, Matthew Bond, Colin Campbell, Susan Ellicott, Keith Hindell, Philip Jacobson, David Hands, Rugby Correspondent, Mary Dejevsky, John Watson,
... PA Multiple Classified Advertising Items Per Search & Selection ORC Multiple Display Advertising Items Sarah Hodge Aspen Hobstones ...
1990 - Gale Group | TDA
Mark G. Alexandrow, Marion Ritzi, Alexander Pemov, Joyce L. Hamlin,
... recognized by a six-membered protein complex called ORC (for origin recognition complex; reviewed in Refs. 11Dutta ... 357: 128-134Crossref PubMed Scopus (988) Google Scholar). ORC binds to origins throughout the cell cycle and ... synthesized and localized to origins via interaction with ORC (11Dutta A. Bell S.P. Annu. Rev. Cell ... 547-563Crossref PubMed Google Scholar). The assemblage of ORC, Cdc6, and the MCM subunits is collectively called ... Loss-of-function mutations in any of the ORC, MCM, or cdc6 genes in yeast impairs replication ...
Tópico(s): Chromosomal and Genetic Variations
2002 - Elsevier BV | Journal of Biological Chemistry
Waldemar Januszczak, Vladimir Putin, Hala Jaber, Ivan Pike, John Dugdale, Nicholas Pyke, Matthew Wall, Steven Simpson, Barbara Hall, Nigel Botherway, Colin Kitt, Nigel Ross, Fred Redwood, Jim Munro, Jon Swain, Helen Davies, Sally Brock, Nicholas Rufford, Rob Hughes, George Georgiou, John Peter, Pam Barrett, V S, Mark Hodgkinson, Tony Eldridge, Jonathan Cox, Jonathan Miller, Professor Gideon Garter, Amanda Ursell, Andrew Longmore, Gurdeep Grewal, J D, Susan d'Arcy, Tom Walters, Irene Hofman, Chris Shelley, Tim Nagle, Gareth Walsh, Frank Whitford, Ivo Tennant, J Phillips, Nicolette Jones, Ferdinand Mount, Sam Gilpin, Charles Peat, Kathryn Cooper, William Lewis, Ian Woosnam, David Smith, Virginia McKenna, Humphrey Carpenter, P D, David Cracknell Political Editor, Nick Pitt, Frederic Raphael, Neil Wormald, E P, Colin Bullen, Andrew Sullivan, Clive Davis, James Glover, Sally Brown, Andrew Porter, Tony Allen-Mills, Simon Wilde, Jonathan Ungoed-Thomas, Robert Winnett, Natasha Garnett, Tim Adams, Irwin Stelzer, Mike Pattenden, Peter Wilson, Rosie Millard, Naimat Arghandabi, Lawrence Dallaglio, David Dougill, Rachel Dobson, Nick Scott, Geraldine Hackett, Matthew Robinson, Nick Speed, Rob Maul, David Hewson, Harold Cohen, David Bond, Jonathon Carr-Brown, Margarette Driscoll, Alasdair Reid, Geraldine Hackett Education Correspondent, Hugh Canning, Jeremy Clarkson, David Cairns, Edward Porter, Peter Conradi, Andrew Oswald, Stewart Lee, Dean Nelson, Debbie Taylor, Victoria Segal, Patricia Nicol, Scott Morris, Sarah Dempster, K E Mawardy, Eben Black, Dave Pollard, John O'Donnell, John Simons, Graham Clutton, David Eimer, Lydia Slater, Karena Batstone, Clive Anderson, Robert Potts, Dr Martin Stephen, Shelley von Strunckel, Doug Sager, Paula Robinson, Phil Stockton, Rick Wakeman, Roger Eglin, Paul Donovan, Tom Conran, Dominique Coughlin, Pat Cash, Pat Hodgson, Tom Stubbs, Monsieur Mangetout, Chris Woodhead, Steve Boyd, Lucinda Kemeny, Jasper Gerard, Emma Thompson, Paul Driver, John Humphrys, Nicholas Hellen, Ian Hawkey, Alex Clark, Christopher Morgan, Lizzie Vann, Bert Wright, Paul Durman, Mark Ludlow, Lisa Grainger, Alicia Wyllie, Arnie Wilson, Mark Edwards, Robin Davis, Susan Clark, Stephen Amidon, Damian Barton, Harriet Perry, Hugo Barnacle, Bryan Oates, Christina Lamb, Tim Lawrence, Victoria O'Brien, Miranda Eeles, Raymond Keene, David Cracknell, Cosmo Landesman, Katrina Manson, Robbie Hudson, Diana Wright, Benji Wilson, Jay Leno, Dominic O'Connell, Stephen Jones, Barry Flatman, Uzi Mahnaimi, Richard Evans, Louise Armitstead, Michael Wright, D Douglas, Bennett Maxwell, Natalie Graham, Kate Rew, Caroline Donald, Nick Rennison, S D, Rob Ryan, Keith Wheatley, Jessica Brinton, Miranda Seymour, David Walsh, Helen Brown, Tom Maynard, Tiffanie Darke, Wilf Altman, Trevor Lewis, Colin McDowell, Stephen Armstrong, John Elliott, John King, Aleks Sierz, Bethan Cole, Roland White, Katrien Nachtergaele, Shane Watson, Alex Fortune, Richard Rae, Mark Franchetti, Ray Hutton, Lauren Quaintance, Marie Pierre Zielinsky, C Nixon, Linda Aston, Michael Sheridan, Clare Francis, Joan Woolard, Simon Potter, John Harlow, D J Taylor, Godfrey Smith, Helen Mound, Victoria Masterson, Don Black, John Waples, Richard de Melim, Jeremy Hart, A A Gill, Matthew Campbell, Robert MacFarlane, James Hillhouse, Trevor Clawson, Alice Elden, Amber Rust, John Carey, David Horspool, Tania Davenport, Nick Fielding, Stephen Pettitt, Anna Tobin, Claudia Croft, Will Iredale, Jonathan Calvert, John Spurling, T L, Maria McErlane, Sally Kinnes, Naomi Caine, Graeme Nation, David Wickers, Francis Warren, Nigel Powell, Roger Dobson, Minette Marrin, John Cornwell, Andrew Frankel, Graham Norwood, Jonathan Futrell, Rupert Steiner, Alan Yentob, William Lewis Business editor, Hugh Pearman, Andrew Davidson, Paul Stephen Lubicz, Dan Cairns, Justin Wintle, Dorothy Wade, David Smith Economics Editor, Cary Cooper, Sarah Baxter, Bob Dwyer, Stuart Kelly, Matthew Goodman, India Knight, Paul Gogarty, Chris Feetenby, Simon Howard, Ed Hughes, Jason Dawe, Dominic Rushe, Richard Lewis, Karen Robinson,
... victory over France Countdown to the World Cup Orc alert: is England's pack seriously lacking in ...
2003 - Gale Group | Sunday Times HA GDA
Wei Sun, Thomas R. Coleman, Melvin Depamphilis,
... in the affinity of the origin recognition complex (ORC) for chromatin are involved in regulating initiation of ... replication. To test this hypothesis, chromatin lacking functional ORCs was isolated from metaphase hamster cells and incubated ... egg extracts to initiate DNA replication. Intriguingly, Xenopus ORC rapidly bound to hamster somatic chromatin in a ... geminin or by depletion of XlMcm proteins, augmented ORC binding by inhibiting ORC release. These results demonstrate a programmed release of ... S phase, consistent with the proposed role for ORC in preventing re-initiation of DNA replication during ...
Tópico(s): RNA Research and Splicing
2002 - Springer Nature | The EMBO Journal
By Our Foreign Staff, From Dessa Trevisan, By Paul Routledge Labour Editor, By David Blake, By Peter Hill Industrial Editor, By George Clark Political Correspondent, By Fred Emery Political Editor, By Our Political Staff, From Our Correspondent, By a Staff Reporter, By Pat Healy Social Services Correspondent, By Stewart Tendler, By John Roper Health Services Correspondent, From Penny Symon, By Nicholas Timmins, From David Nicholson-Lord, By Michael Hatfield Political Reporter, By Our Consumer Affairs Correspondent, By Diana Geddes Education Correspondent, By Frances Gibb, By Michael Baily Transport Correspondent, By Robin Young Consumer Affairs Correspondent, By Peter Evans Home Affairs Correspondent, By Peter Hennessy, By Our Home Affairs Correspondent, By John Young Planning Reporter, By Our Crime Reporter, By Pearce Wright Science Editor, By Christopher Warman Local Government Correspondent, By Annabel Ferriman, By Craig Seton, From David Wood, From Our Own Correspondent, From Patricia Clough, From Peter Nichols, From Ian Murray, From Michael Hornsby, From David Cross, By Our Political Editor, From Michael Binyon, From David Spanier Diplomatic Correspondent, From Christopher Walker, By Henry Stanhope Defence Correspondent, From Robert Fisk, By Hugh Noyes Parliamentary Correspondent, From Nicholas Ashford, By David Watts, From Richard Hughes, From Neil Kelly, From Eric Marsden, By Roger Berthoud, Marcel Berlins Legal Correspondent, Shona Crawford Poole, By Norman Fox Football Correspondent, David Hands, By Srikumar Sen Boxing Correspondent, By Rex Bellamy Tennis Correspondent, From John Woodcock Cricket Correspondent, By Rex Bellamy, From Richard Streeton, Bu Sydney Friskin, By John Hennessy, Michael Ratcliffe, A. M. Rendel, Robert Nye, Robert Mark, Elaine Feinstein, H.R.F. Keating, John Russell Taylor, Joan Bakewell, Paul Griffiths, William Mann, Ronald Butt, Bernard Levin, Martin Huckerby, DAVID BAGGLEY, , JEREMY GANN, , S. COLBRAN, , JAMES JARDINE, , A. M. MACARTHUR, , R. T. SEVERN, , MARGARET BROWN, , HUGH WEEKS, , DAVD CROUCH, , K. P. FRAMPTON, , F. W. COLLINS, , ROBERT SKIDELSKY, , NORA BELOFF, , MICHAEL S. MOSS, , By Our Music Reporter, By the Staff of Nature, By Kenneth Gosling Arts Reporter, By Norman Hammond, A friend writes:, Professor S. Dillon Ripley, By Geraldine Norman Sale Room Correspondent, Benjamin Luxon writes:, By Nicholas Hirst Energy Correspondent, By David Blake Economics Editor, John Huxley, By Caroline Atkinson, By Kenneth Owen, By Philip Robinson, Koji Nakamura, From Peter Norman, By Derek Harris Commercial Editor, By David Hewson, By David Felton, H. S. HILL, , JOHN SAYER, , D. M. L. ALEXANDER, , A. S. BRODE, , H. M. WILLIAMS, , FRED HARDMAN, , STANLEY STEWARD, , BY THE FINANCIAL EDITOR, Ross Davies, Caroline Atkinson, Frank Vogl, By Alison Mitchell, By Peter Wainwright, By Michael Prest, Edited by Peter Davalle,
... Boy was crushed to death by giant snowball, Orc Survey Voters in right mood for formation of ...
1980 - Gale Group | TDA
Dragana Stefanovic, Slavica Stanojčić, Alessandro Vindigni, Alexander Ochem, Arturo Falaschi,
... bound in vivo by the origin recognition complex (ORC). In order to analyze the in vitro interactions ... of preparations of HeLa nuclear proteins containing the ORC complex. Here we show that both HsOrc4 alone ... activity of HeLa cells requires the presence of ORC and can be reproduced in the absence of ... proteins known to be recruited to origins by ORC. Both HsOrc4 alone and HeLa nuclear proteins exhibit ... vitro approach points to the sequence requirements for ORC binding as a key element for origin recognition. ...
Tópico(s): Nuclear Structure and Function
2003 - Elsevier BV | Journal of Biological Chemistry
Andrew Robson, David Adams, David Charter Health Correspondent, Robert Cole, Andrew Pierce, James Moore, Zahid Hussain, Sarah Potter, Magnus Linklater, Peter Lansley, David Rhys Jones, Matt Wolf, Philip Howard, Ian Cobain, Adam Mars-Jones, David Chater, Joanna Bale, James Bone, David Squire, Gillian Harris Scotland Correspondent, Barbara Ellen, Paul wilkinson, Geoff Brown, M. R. Lewis, Joe Joseph, Giles Coren, Andrew Norfolk, John O'Leary Education Editor, Martin Fletcher, Pat Gibson, Valerie Elliott Countryside Editor, Stewart Tendler Crime Correspondent, Jeff Dunne, Dominic Walsh, Ruth Gledhill, Susan Sturrock, Dominic Walsh and Sally Patten, Ross Dunn, Martin Barrow, Ed Cairney, Richard Ford Home Correspondent, J. G. K. Birch, Alan Hamilton, Oliver Wright, Robert Bruce, Anatole Kaletsky, James Landale Political Correspondent, David Hands, Charles Bremner, Helen Rumbelow, Damian Barr, Greg Hurst, Peter Barnard, Mark Court, Caroline Merrell Banking Correspondent, James Doran City Correspondent, Angela Jameson, Russell Kempson, Oliver Kay, Walter J. Ablett, David Lister, Michael Theodoulou, Jonny McIrvine, Matt Dickinson Football Correspondent, Jill Sherman Whitehall Editor, Barry Millington, Simon de Bruxelles, Rob Wright, Adam Jones, David Powell Athletics Correspondent, Raymond Keene, Sean MacAulay, Philip E. Roe, David Hands and Lewis Stuart, Philip Webster and Roland Watson, Chris Partridge, Nigel Cliff, Beryl Dixon, Greg Hurst Parliamentary Correspondent, Nigel Hawkes, Bronwen Maddox, Oliver Holt, Richard Owen, Brian Gilbert, Christopher Martin-Jenkins Chief Cricket Correspondent, Emily Davies, Oliver August, Nick Hasell, Richard Holledge, David Hands Rugby Correspondent, David Cruickshank, Helen Carroll, Adam Fresco, Mike Mulvihill, Martin Fletcher European Correspondent, John Goodbody, James Doran, Mel Webb, Ian Johns, Annie Turner, Kevin McCarra, Matthew Parris, Graham Searjeant Financial Editor, Chris McGrath, George Caulkin, Glen Owen Education Correspondent, Mark Court Health Industries Correspondent, Peter Riddell, Ben MacIntyre, Roy Hattersley, John Goodbody Sports News Correspondent, Richard Miles, Gary Duncan Economics Correspondent, Martin Waller, Chris Ayres, James Jackson, Laura Peek, Nigel Hawkes Health Editor, Christopher Andrew, Benedict Nightingale, Dr Thomas Stuttaford, David Powell, Bill Edgar, Sam Kiley, Richard Morrison, James Christopher, John de Bono, Arthur Leathley, Adam Sherwin, Susan MacDonald, Tom Baldwin Deputy Political Editor, Roland Watson Chief Political Correspondent, Jennifer Meech, Terence Conran, Thomas Stuttaford, Ben Webster and Arthur Leathley, Kim Newman, Emma Burns, Richard Ford, Sally Patten Retail Correspondent, Richard Beeston Diplomatic Correspondent, Joanna Coles,
... No Title Times Newspapers DH Department of Health ORC International Yaadgaar Sweets Multiple Display Advertising Items The ...
2001 - Gale Group | TDA
Yasutoshi Tatsumi, Satoshi Ohta, Hiroshi Kimurâ, Toshiki Tsurimoto, Chikashi Obuse,
Components of ORC (the origin recognition complex) are highly conserved among eukaryotes and are thought to play an essential role in ... The level of the largest subunit of human ORC (ORC1) during the cell cycle was studied in ... S phase. In contrast, the levels of other ORC subunits (ORCs 2–5) remain constant throughout the cell cycle. ... cycle and preventing origins from refiring. Components of ORC (the origin recognition complex) are highly conserved among ... The level of the largest subunit of human ORC (ORC1) during the cell cycle was studied in ...
Tópico(s): Cancer-related Molecular Pathways
2003 - Elsevier BV | Journal of Biological Chemistry
Renata Dziak, David Leishman, Maja Radovic, Bik K. Tye, Krassimir Yankulov,
... 1The abbreviations used are: MCM, mini-chromosome maintenance; ORC, origin recognition complex; CDC, cell division cycle; LTR, ... in a manner dependent on origin recognition complex (ORC) and Cdc6 (2Lei M. Tye B.K. J. ... However, genome-wide mapping of the association of ORC and MCM proteins to chromatin (22Wyrick J.J. ... sites for these complexes. Only 79% of the ORC·MCM binding sites on chromosome X serve as origins. Another notable feature of ORC·MCM distribution is the clustering of ORC·MCM at telomeres, near Ty-transposable elements as ...
Tópico(s): RNA Research and Splicing
2003 - Elsevier BV | Journal of Biological Chemistry
Satoshi Ohta, Yasutoshi Tatsumi, Masatoshi Fujita, Toshiki Tsurimoto, Chikashi Obuse,
The origin recognition complex (ORC) plays a central role in regulating the initiation of DNA replication in eukaryotes. The level of the ORC1 subunit oscillates ... and is degraded in S phase, although other ORC subunits (ORCs 2–5) remain at almost constant levels. The behavior of ORC components in human cell nuclei with respect to the ORC1 cycle demonstrates that ORCs 2–5 form a complex that is present ... with ORC1 when it accumulates in G1 nuclei. ORCs 2–5 are found in both nuclease-insoluble and -soluble fractions. The appearance of nuclease-insoluble ORCs 2–5 parallels the increase in the level ...
Tópico(s): DNA and Nucleic Acid Chemistry
2003 - Elsevier BV | Journal of Biological Chemistry
Masaki Makise, Hitomi Takenaka, Wakako Kuwae, Naoko Takahashi, Tomofusa Tsuchiya, Tohru Mizushima,
Origin recognition complex (ORC), a candidate initiator of chromosomal DNA replication in eukaryotes, binds specifically to ATP through two of its subunits (Orc1p ... we investigated the kinetics of ATP binding to ORC by a filter binding assay. The Kd values for the ATP of wild-type ORC and ORC-1A (mutant ORC containing Orc1p with a defective Walker A motif) ... hand, the Kd values for the ATP of ORC-5A (mutant ORC containing Orc5p with a defective Walker A motif) ... ATP dissociated more rapidly from its complex with ORC-5A than from its complex with ORC-1A, ...
Tópico(s): Drug Transport and Resistance Mechanisms
2003 - Elsevier BV | Journal of Biological Chemistry
Daniel Spangler, Stephen Rothenburger, Kien T. Nguyen, Hanuman B. Jampani, Scott Weiss, Shubhangi Bhende,
... pH, which is produced by oxidized regenerated cellulose (ORC), is a broad-spectrum physiological detriment to survival ... study was to examine the antimicrobial effect of ORC against antibiotic-resistant organisms.ORC products were challenged with ATCC reference strains and ... S. aureus and Pseudomonas aeruginosa. Samples of three ORC products (SURGICEL absorbable hemostat, SURGICEL Fibrillar absorbable hemostat, ... NU-KNIT absorbable hemostat and identified, respectively, as ORC-R, ORC-F, and ORC-N for this ...
Tópico(s): Surgical Sutures and Adhesives
2003 - Mary Ann Liebert, Inc. | Surgical Infections