John Huxley, Malcolm Brown, John Goodwin, Barbara Hall, Jim Tucker, Richard Ellis, Lucian Freud, John Jay City Editor, John Davison, Jon Swain, Catherine Bennett, Philip Norman, Rob Hughes, John Peter, Philips Drew, Jonathan Miller, Eric Dymock, Jill Hartley, Christopher Smallwood Economics Editor, Brian Deer Social Affairs Correspondent, Sarah Miller, John Jay, Geordle Greig, Snehlata Patel, J Shepherd, Geoffrey Lee Editor, Nick Rufford, Danby Bloch, Graham Rose, Alistair Scott, Julia Brookes, Celia Hammond, Stephen Milligan, Marten Julian, Jason Tomas, John Rowland, Mark Hosenball, Edward Welsh, Carol Sarler, Deborah Moggach, Caroline St John-Brooks, John Westwell, Jon Craig, Judy Goldhill, Patrick Stoddart, Susan Marling, Kevin Mitchell, Robert Sandall, Iain Johnstone, Alex Sutherland, David Brierley, Irwin Stelzer, Peter Godwin, Robert Hewison, Ivan Fallon, Deryk Brown, Mick Brown, David Dougill, Joe Irving, Dymphna Byrne, Cliff Temple, Jane Bird, Alfred Brendel, Tavleen Singh Amritsar, Philip Beresford Industrial Editor, John Witherow, Dr A Williams, Muriel Spark, Christine Walker, Egon Ronay, Susan Crosland, Peter Kemp, John Ballantine, Norman Harris, Richard Burton, David Connett, Robert Tapsfield, Geoff Whitten, M Catty, Dr P Drew, Richard Linning, John Newman, Andrew Weir, John Cassidy, Sue Mott, Brian Moynihan, Clive Freeman, Jean Simister, Bernard Cafferty, Lesley Abdela, Brian Moynahan, Huston Horn, D G Moss, Paul Taylor, Robert Muller, James Adams, Marjorie Wallace, David Hughes, Graham Jenkins, Austin MacCurtain, David Leppard, Blake Pinnell, Mazher Mahmood, Matthew, Carrie French, Wendy McFadden, Nigel Bowden, Martin Jacques, Brian Walden, Roger Williams, Peter Wilsher, Gill Charlton, Gareth David, Dr F Wright, Ronald Katz, Stephen Pile, Dr Mark Stocker, Peter Scott, Malcolm Winton, J. H. Perryman, Richard Cook, Marie Colvin, Michael Brooks, Craig Brown, Katherine Stephen, Christopher Smallwood, Nick Smurthwaite, Brian Court-Mappin, Dr Ivan Tucker Principal, Tony Peisley, Stephen Jones, Michel Syrett, Anthony Cavendish, Eric Hobsbawm, Raymond Barre, Richard Palmer, Raymond Godfrey, Roberta Bearing, Paul Gogerty, Keith Wheatley, Dadu Patel, Patrick Rowley, Dilys Powell, Roger Eglin Business Editor, Brough Scott, Deyan Sudjic, Alison Beckett, Tony Rocca, Dr G Coles, Caroline McGhie, Richard Woods, Nicholas Bethell, Louise Branson, Norman Stone, S Semons, Maurice Chittenden, Ian Dunning, Iola Smith, Felix Aprahamian, Dr Robert Burchfield, Andrew Sinclair, Arun Desai, Elena Ceasescu, David Hughes Political Correspondent, Brian MacArthur, Michael Jones Political Editor, Adrian Spooner, Steve Tongue, Philip Beresford, Saadi Haeri, Nicholas Kochan, Hugh Lloyd-Jones, Russell Harty's, Michèle Jaffé-Pearce, Credit Suisse First Boston, Brian Glanville, Angus Roxburgh, Burt Keimach, Edward Pearce, Anthony Holden, Simon Jenkins, Godfrey Golzen, Jon Craig Home Affairs Correspondent, David Sinclair, Howard Jacobson, Patricia Mowbray, John Grant, A Needham, Anne Jarvis, Ian Williams, Allan Cooper, Valerie Grove, Hugh Pearman, Alexander MacLeod, Marina Vaizey, Margaret Park, Angela Long Innovation Editor, Tony James, Anthony Smith, Tony Hetherington, Peter Roebuck, Joanna Simon, Ellen Pennington, Boris Schapiro,
... College Prestige Homes Ltd L' Escala Costa Brava Prado, Asua & Co. Multiple Classified Advertising Items St. Aldates ... Travel Turkey Travellers Abroad American Travel Centre Florida Orlando USA Canada Genuine Low Fares Travel Australia Club ...
1988 - Gale Group | Sunday Times HA GDA
Produção Nacional
Revisado por pares
Diogo Fernandes dos Santos, José Luiz Pedroso, Pedro Braga‐Neto, Giselle Melo Fontes Silva, Luciane Bizari Coin de Carvalho, Lucila Bizari Fernandes do Prado, Orlando Graziani Póvoas Barsottini, Gilmar Fernandes do Prado,
Machado-Joseph disease (MJD) is a neurodegenerative disease which usually presents several clinical findings including cerebellar ataxia and other extracerebellar features, such as Parkinsonism, dystonia, peripheral neuropathy, and lower motor neuron disease. Some data have demonstrated a high frequency of sleep disorders in these patients, including excessive daytime sleepiness (EDS), insomnia, obstructive sleep apnea (OSA), rapid eye movement (REM) sleep behavior disorder (RBD), and restless legs syndrome ( ...
Tópico(s): Glycogen Storage Diseases and Myoclonus
2014 - Elsevier BV | Sleep Medicine
Julia Llewellyn Smith, Jon Ashworth, Edward Owen, Andrew Pierce, Alexandra Frean, James Haskel, Andrew Longmore, Ronald Faux, Janet Bush, Economics Correspondent, Ross Tieman, Industrial Correspondent, Nicholas Wood, Jill Sherman and Arthur Leathley, Philip Howard, R. E. Andrews, Hilary Finch, Jeremy Kingston, Alexandra Frean Media Correspondent, Noel Goodwin, Carl Mortished, Hugh I. Grant (Managing Director), Mike Calvert, Simon Wilde, Stuart Jones Tennis Correspondent, Robert Sheehan, Bridge Correspondent, Robert Miller, Stefan B. Tietz, Jonathan Eyal, Martin Fletcher, Ben Preston Education Correspondent, Roger Boyes and George Brock, R. M. Battle, John Hopkins, Golf Correspondent, John O'leary, Education Editor, Raymond Keene Chess Correspondent, John Street, Richard Evans, Racing Correspondent, Peter Waymark, Michael Evans, Defence Correspondent, Richard Ford Home Correspondent, Chris Cramer, Rodney Milnes, Michael Clark, Eve-Ann Prentice, Diplomatic Correspondent and Stacy Sullivan, Eve-Ann Prentice, John O'Leary, John Young, Jeremy Laurance, Health Correspondent, Janet Bush, Eve-Ann Prentice Diplomatic Correspondent, David Hands, Sarah Bagnall, Philip Bassett, Industrial Editor, Patricia Tehan, Banking Correspondent, Simon Tait, Richard Cork, Charles W. Palmer, A. Howard, Barry Sutton, David Miller, Lin Jenkins, Paul Sexton, Gregory Segal, Dalya Alberge, Arts Correspondent, Tim Mickleburgh, Raymond Keene, Adam Sage, Peter Davalle, Alan Lee, Cricket Correspondent, Frances Gibb, Legal Correspondent, P. H. S, Alix Ramsay, Rachel Collins, Alan Jones, Richard Evans, Eric Reguly, Oliver Holt, Hermann Bondi (President), Philip Webster, Political Editor, Kate Alderson, Nicholas Wood, Chief Political Correspondent, Nicholas Wood, John Goodbody, Christopher Walker, Chris Parker, Brian MacArthur, Mel Webb, Christine Webb, Claire Pilton, Peter Riddell, Ben MacIntyre, Brian Clarke, Simon Jenkins, Tim Jones, Kate Bassett, Alan Coren, Terry Maher, Tom Rhodes, Dr Thomas Stuttaford, Jill Sherman, Political Correspondent, Christopher Patten, Alice Thomson, Political Reporter, Martin Waller Deputy City Editor, Ben Preston and Edward Gorman, Walter Ellis, David Hands, Rugby Correspondent, Jonathan Mirsky, John M. Meade, Sam Kiley, Africa Correspondent,
... News 1,300 architects vie to renovate the Prado Amnesty frees 1,500 French criminals Dell Bonn ... in Brief Motor Insurance The Dream who is Orlando's living nightmare Oliver Holt reports from Houston ...
1995 - Gale Group | TDA
Produção Nacional
Revisado por pares
Thiago Cardoso Vale, José Luiz Pedroso, Lívia Almeida Dutra, Lyamara Apostólico de Azevedo, Lúcio Huebra Pimentel Filho, Lucila Bizari Fernandes do Prado, Romana Höftberger, Gilmar Fernandes do Prado, Orlando Graziani Póvoas Barsottini,
A 65-year-old right-handed businessman presented with a 3-month history of worsening muscle twitching and painful proximal muscle spasms, excessive sweating, constipation, cold hands, and a burning sensation in his feet. He had lost 10 kg and his wife reported that he seemed to have hallucinations during sleep. He had no relevant family or alcohol history, and was an ex-smoker with a 10 pack-year history.
Tópico(s): Glycogen Storage Diseases and Myoclonus
2017 - Elsevier BV | The Lancet
Produção Nacional
Revisado por pares
Thiago Cardoso Vale, Lucila Bizari Fernandes do Prado, Gilmar Fernandes do Prado, Orlando Graziani Póvoas Barsottini, José Luiz Pedroso,
Study Objectives:To report two female patients with paraneoplastic cerebellar degeneration (PCD) related to breast cancer that presented with rapid eye movement-sleep behavior disorder (RBD) and improved sleep symptoms with immunotherapy.
Tópico(s): Genetics and Neurodevelopmental Disorders
2015 - Oxford University Press | SLEEP
Produção Nacional
Revisado por pares
José Luiz Pedroso, Edson Bor‐Seng‐Shu, Pedro Braga‐Neto, Rodrigo Souza Ribeiro, Márcio Luiz Escórcio Bezerra, Lucila Bizari Fernandes do Prado, Ilza Rosa Batista, Helena Alessi, Manoel Jacobsen Teixeira, Gilberto Mastrocola Manzano, Gilmar Fernandes do Prado, Orlando Graziani Póvoas Barsottini,
Tópico(s): Neurological disorders and treatments
2014 - Springer Science+Business Media | The Cerebellum
Produção Nacional
Revisado por pares
José Luiz Pedroso, Wladimir Bocca Vieira de Rezende Pinto, Paulo Victor Sgobbi de Souza, Irapuá Ferreira Ricarte, Michele Christine Landemberger, Vilma R. Martins, Lucila Bizari Fernandes do Prado, Gilmar Fernandes do Prado, Orlando Graziani Póvoas Barsottini,
Fatal familial insomnia (FFI) represents a rare neurodegenerative autosomal dominant prion disease, usually affecting patients between the fifth and sixth decades, evolving rapidly to death.1,2 FFI results from a missense mutation at codon 178 (D178N) of the PRNP gene (located on chromosome 20p13) linked with methionine at codon 129 of the mutated allele. Its major neuropathologic features include severe neuronal loss with astrogliosis of mediodorsal and ventral anterior thalamic nuclei and inferior ...
Tópico(s): RNA regulation and disease
2013 - Lippincott Williams & Wilkins | Neurology
Produção Nacional
Revisado por pares
José Luiz Pedroso, Pedro Braga‐Neto, André C. Felício, Thaı́s Minett, Elton Yamaguchi, Lucila Bizari Fernandes do Prado, Luciane Bizari Coin de Carvalho, Lívia Almeida Dutra, Marcelo Q. Hoexter, Antônio José da Rocha, Rodrigo A. Bressan, Gilmar Fernandes do Prado, Orlando Graziani Póvoas Barsottini,
Objectives Sleep disorders, especially restless legs syndrome (RLS) and rapid eye movement sleep behavior disorder (RBD), are common in spinocerebellar ataxia type 3 or Machado–Joseph disease (MJD), and a possible underlying dopaminergic dysfunction is implicated. This study assessed the relationship between sleep disorders in MJD and dopamine transporter (DAT) densities. Patients and methods Twenty-two patients with MJD and twenty healthy subjects were enrolled in this study. MJD patients underwent ...
Tópico(s): Neurological disorders and treatments
2012 - Elsevier BV | Journal of the Neurological Sciences
Produção Nacional
Revisado por pares
José Luiz Pedroso, Pedro Braga‐Neto, André C. Felício, Lívia Almeida Dutra, William Adolfo Celso dos Santos, Gilmar Fernandes do Prado, Orlando Graziani Póvoas Barsottini,
Tópico(s): Genetic Neurodegenerative Diseases
2011 - Springer Science+Business Media | The Cerebellum
Produção Nacional
Revisado por pares
José Luiz Pedroso, Pedro Braga‐Neto, André C. Felício, Camila C. Aquino, Lucila Bizari Fernandes do Prado, Gilmar Fernandes do Prado, Orlando Graziani Póvoas Barsottini,
Cerebellar ataxias comprise a wide range of etiologies leading to central nervous system-related motor and non-motor symptoms. Recently, a large body of evidence has demonstrated a high frequency of non-motor manifestations in cerebellar ataxias, specially in autosomal dominant spinocerebellar ataxias (SCA). Among these non-motor dysfunctions, sleep disorders have been recognized, although still under or even misdiagnosed. In this review, we highlight the main sleep disorders related to cerebellar ...
Tópico(s): Neurological disorders and treatments
2011 - Thieme Medical Publishers (Germany) | Arquivos de Neuro-Psiquiatria
Chanjuan Shi, Anna Szcześniak, Lucy Mao, Christine A. B. Jollimore, Miguel Coca‐Prados, Orlando Hung, Michael E. Kelly,
We examined A3 adenosine and CB1 cannabinoid receptor‐coupled signaling pathways regulating Cl − current in a human nonpigmented ciliary epithelial (NPCE) cell line. Whole‐cell patch‐clamp recordings demonstrated that the A3 receptor agonist, IB‐MECA, activates an outwardly rectifying Cl − current ( I Cl,Aden ) in NPCE cells, which was inhibited by the adenosine receptor antagonist, CGS‐15943 or by the protein kinase C (PKC) activator, phorbol 12,13 dibutyrate (PDBu). Treatment of NPCE cells with pertussis‐ ...
Tópico(s): Ion channel regulation and function
2003 - Wiley | British Journal of Pharmacology
Produção Nacional
Revisado por pares
Felipe Augusto Folha Santos, Luciane Bizari Coin de Carvalho, Lucila Prado, Gilmar Fernandes do Prado, Orlando Graziani Póvoas Barsottini, José Luiz Pedroso,
Machado-Joseph disease (MJD) or spinocerebellar ataxia type 3 (SCA3) is the most common type of autosomal dominant spinocerebellar ataxia (SCA). Sleep disorders have been described as frequent non-motor symptoms in MJD, and with marked impairment on quality of life. However, few studies have evaluated the frequency and characteristics of sleep apnea in MJD.This study analyzed the prevalence of sleep apnea in 47 patients with MJD by using polysomnography. Clinical variables such as age, age at onset ...
Tópico(s): Parkinson's Disease Mechanisms and Treatments
2018 - Elsevier BV | Sleep Medicine
Produção Nacional
Revisado por pares
André Cavalcanti, Maria Odete Esteves Hilário, Flávia H. Santos, Sílvia Adriana Prado Bolognani, Orlando Francisco Amodeo Bueno, Cláudio Arnaldo Len,
To evaluate the neuropsychological profile and health-related quality of life (HRQOL) of adults who had rheumatic fever (RF) during childhood with and without Sydenham's chorea (SC).Three groups of patients were assessed: adults who had RF with SC during childhood (SC group), adults who had RF without SC during childhood (RF group), and controls (CT group). A range of neuropsychological tests looked at several cognitive domains. HRQOL was measured through a Brazilian version of the Short Form 36 (SF-36) ...
Tópico(s): Williams Syndrome Research
2010 - Wiley | Arthritis Care & Research
B.M. Prado, Baraem Ismail, Orlando Rivera Ramos, K.D. Hayes,
Thermal stabilities of bovine plasminogen (PG) activators, tissue and urokinase type (t-PA and u-PA), and their impact on activation of PG, were studied after application of various heating conditions (65, 75, 85, or 90 °C for 15, 20, or 30 s), in both milk and buffer systems. Both t-PA and u-PA were thermally stable in milk heated at ⩽75 °C. However, almost half of the t-PA activity and 30% of u-PA activity was lost after heating milk at 85 °C for 30 s. A lower heat stability of both t-PA and u-PA was ...
Tópico(s): Protease and Inhibitor Mechanisms
2007 - Elsevier BV | International Dairy Journal
Produção Nacional
Revisado por pares
Carlos Edmundo Rodrigues Fontes, Murched Omar Taha, Djalma José Fagundes, Marcos Victor Ferreira, Orlando Ribeiro Prado Filho, Marino José Mardegan,
OBJETIVO: estudar comparativamente o uso de cianoacrilato e cola de fibrina no reparo do ferimento hepático, para evidenciar suas respectivas capacidades de integração aos tecidos à curto prazo. MÉTODOS: 30 ratos Wistar-EPM1 foram separados em 2 grupos e submetidos à anestesia com tiopental na concentração de 40mg/kg EV. Realizada laparotomia com exposição do fígado. Usando um "punch" dermatológico de 3mm foi produzido um ferimento padronizado em lobo direito hepático. Os animais do grupo A foram ...
Tópico(s): Hernia repair and management
2004 - Sociedade Brasileira Para o Desenvolvimento da Pesquisa em Cirurgia | Acta Cirúrgica Brasileira
Produção Nacional
Revisado por pares
Anderson M. Santos, Ademar Wong, Thiago Martimiano do Prado, Elson Luiz Fava, Orlando Fatibello‐Filho, Marı́a Del Pilar Taboada Sotomayor, Fernando C. Moraes,
The present work reports the development of a sensitive and selective method for ethinylestradiol detection using screen-printed electrode (SPE) modified with functionalized graphene (FG), graphene quantum dots (GQDs) and magnetic nanoparticles coated with molecularly imprinted polymers ([email protected]). The performance of the [email protected] sensor was compared with that of a non-molecularly imprinted sensor ([email protected]). Chemical and physical characterizations of the [email protected] and [email ...
Tópico(s): Electrochemical Analysis and Applications
2020 - Elsevier BV | Talanta
Produção Nacional
Revisado por pares
Rafael M. Cardoso, Pablo R.L. Silva, Ana P. Lima, Diego P. Rocha, Thiago C. Oliveira, Thiago Martimiano do Prado, Elson Luiz Fava, Orlando Fatibello‐Filho, Eduardo M. Richter, Rodrigo A.A. Muñoz,
Additive manufacturing, also known as 3D-printing, is receiving great interest by chemists due to the easy design of novel materials, fast prototyping and reducing waste, which enables large-scale fabrication of electrochemical devices. Herein we demonstrate the development of (bio)sensors for the analysis of biological fluids using 3D-printing. Fused deposition modelling was used to fabricate (bio)sensing platforms from commercially-available filaments made of polylactic acid containing graphene ( ...
Tópico(s): Biosensors and Analytical Detection
2019 - Elsevier BV | Sensors and Actuators B Chemical
Produção Nacional
Revisado por pares
José Luiz Pedroso, Pedro Braga‐Neto, Alberto Martínez, Carlos Roberto Martins, Flávio Moura Rezende Filho, Manoel Alves Sobreira-Neto, Lucila Bizari Fernandes do Prado, Gilmar Fernandes do Prado, Marcondes C. França, Orlando Graziani Póvoas Barsottini,
This article provides a description on clinical features and pathophysiology of the main sleep disorders observed in Machado-Joseph disease (MJD).Pathological studies have clearly demonstrated that degenerative process in MJD is widespread in the nervous system, and not restricted to the cerebellum. Nonmotor manifestations are frequent and may include pain, cramps, dysautonomia, cognitive deficits, psychiatric manifestations, olfactory deficits, fatigue, nutritional issues, and sleep disorders.Sleep ...
Tópico(s): Restless Legs Syndrome Research
2016 - Lippincott Williams & Wilkins | Current Opinion in Psychiatry
Produção Nacional
Revisado por pares
José Luiz Pedroso, Edson Bor‐Seng‐Shu, André C. Felício, Pedro Braga‐Neto, Lívia Almeida Dutra, Camila C. Aquino, Henrique Ballalai Ferraz, Gilmar Fernandes do Prado, Manoel J. Teixeira, Orlando Graziani Póvoas Barsottini,
Abstract Objective Hyperechogenicity of the substantia nigra is a frequent observation on transcranial sonography in Parkinson's disease and Machado–Joseph disease patients. Additionally, restless legs syndrome is a sleep disorder that is also frequently found in both diseases. Autopsy studies have demonstrated increased SN iron content in hyperechogenic substantia nigra. Iron storage is also known to be involved in restless legs syndrome. We formally compared echogenicity of the substantia nigra with restless ...
Tópico(s): Transcranial Magnetic Stimulation Studies
2012 - Elsevier BV | Journal of the Neurological Sciences
Produção Nacional
Revisado por pares
Thaís Bianca Brandão, César A. Migliorati, Aljomar José Vechiato Filho, Wagner Gomes da Silva, Ana Carolina Prado Ribeiro, Orlando Parise-Junior, Luiz Paulo Kowalski, Alan Roger Santos‐Silva,
During the current pandemic scenario, maxillofacial rehabilitation specialists involved with supportive care in cancer must transform its practice to cope with COVID-19 and improve protocols that could quickly return the oral function of complex cancer patients who cannot wait for surgical complex rehabilitation. This includes the role of the maxillofacial prosthodontist for the rehabilitation of surgically treated patients with maxillary cancers by the means of filling obturator prostheses that ...
Tópico(s): Dental Research and COVID-19
2020 - Springer Science+Business Media | Supportive Care in Cancer
Produção Nacional
Revisado por pares
Giselle Melo Fontes Silva, José Luiz Pedroso, Diogo Fernandes dos Santos, Pedro Braga‐Neto, Lucila Bizari Fernandes do Prado, Luciane Bizari Coin de Carvalho, Orlando Graziani Póvoas Barsottini, Gilmar Fernandes do Prado,
Spinocerebellar ataxias (SCA) are autosomal dominant neurodegenerative disorders that affect the cerebellum and its connections, and have a marked clinical and genetic variability. Machado-Joseph disease (MJD) or spinocerebellar ataxia type 3 (SCA3)--MJD/SCA3--is the most common SCA worldwide. MJD/SCA3 is characterized classically by progressive ataxia and variable other motor and non-motor symptoms. Sleep disorders are common, and include rapid eye movement (REM) sleep behaviour disorder (RBD), restless ...
Tópico(s): Sleep and Wakefulness Research
2015 - Wiley | Journal of Sleep Research
Produção Nacional
Revisado por pares
Thiago Martimiano do Prado, Fernando Henrique Cincotto, Orlando Fatibello‐Filho, Fernando C. Moraes,
Abstract The nanocomposite material bismuth vanadate and reduced graphene oxide BiVO 4 /rGO was prepared and deposited onto a fluorine‐doped tin oxide glass surface for application of a photoelectrochemical sensor for the determination of sodium diclofenac in urine samples. This drug is considered as an emergent pollutant because of its ecotoxicological risk when discarded in wastewater. Electrochemistry Impedance Spectroscopy experiments shown that the rGO contributed to the efficiency of the DCF ...
Tópico(s): Advanced biosensing and bioanalysis techniques
2018 - Wiley | Electroanalysis
Produção Nacional
Revisado por pares
José Luiz Pedroso, Márcio Luiz Escórcio Bezerra, Pedro Braga‐Neto, Denise Spinola Pinheiro, Thaı́s Minett, Gilmar Fernandes do Prado, Gilberto Mastrocola Manzano, Orlando Graziani Póvoas Barsottini,
<i>Objective:</i> To evaluate a group of spinocerebellar ataxia type 3 (SCA3) or Machado-Joseph disease (MJD) (SCA3/MJD) patients and assess whether there is an association between neuropathy and serum ferritin levels and restless legs syndrome (RLS). <i>Methods:</i> Twenty-six SCA3/MJD patients underwent electromyography studies to check for neuropathy. Their serum ferritin levels were measured as well. These findings were evaluated based on the presence or not of RLS and its severity. < ...
Tópico(s): Sleep and Wakefulness Research
2011 - Karger Publishers | European Neurology
Andaine Seguin‐Orlando, Mikkel Schubert, Joël Clary, Julia Stagegaard, Marı́a Teresa Alberdi, José Luis Prado, Alfredo Prieto, Eske Willerslev, Ludovic Orlando,
Ancient DNA extracts consist of a mixture of endogenous molecules and contaminant DNA templates, often originating from environmental microbes. These two populations of templates exhibit different chemical characteristics, with the former showing depurination and cytosine deamination by-products, resulting from post-mortem DNA damage. Such chemical modifications can interfere with the molecular tools used for building second-generation DNA libraries, and limit our ability to fully characterize the ...
Tópico(s): RNA and protein synthesis mechanisms
2013 - Public Library of Science | PLoS ONE
Produção Nacional
Revisado por pares
Thiago Martimiano do Prado, Amanda Carrico, Fernando Henrique Cincotto, Orlando Fatibello‐Filho, Fernando C. Moraes,
A photoelectrochemical sensor for dopamine was fabricated by the immobilization of bismuth vanadate (BiVO4) and graphene quantum dots on a fluorine-doped tin oxide (FTO) glass electrode. Electrochemical impedance spectroscopy experiments demonstrated that the presence of graphene quantum dots contributed to the decrease in charge transfer resistance of the sensor under irradiation of visible light in the presence of dopamine. The photocurrent signals obtained were proportional to the dopamine concentration ...
Tópico(s): Quantum Dots Synthesis And Properties
2019 - Elsevier BV | Sensors and Actuators B Chemical
Produção Nacional
Revisado por pares
Carlos Edmundo Rodrigues Fontes, Marino Jose MARDEGAM, Orlando Ribeiro PRADO-FILHO, Marcos Victor Ferreira,
ABSTRACT Background Obtaining effective hemostasis either in the traumatic or surgical lesions of parenchymal viscera, especially the liver, has always been a challenge. Aim: Comparative study between the use of different hemostatic sponges in hepatic wound and their capacity of integration to cells in a short period. Methods: Fifteen Wistar rats were divided into three groups. Through laparotomy a standardized wound in hepatic right lobe was made. The animals were treated with three sponges, being ...
Tópico(s): Trauma, Hemostasis, Coagulopathy, Resuscitation
2018 - Colégio Brasileiro de Cirurgia Digestiva | ABCD Arquivos Brasileiros de Cirurgia Digestiva (São Paulo)
Produção Nacional
Revisado por pares
Emmanuel A. Burdmann, Viktória Woronik, E B A Prado, R. C. Abdulkader, Luiz Balthazar Saldanha, Orlando C. O. Barreto, Marcello Marcondes,
Acute renal failure (ARF) has been frequently reported after bites from the Viperidae snake family. The lack of a reproducible animal model has hampered the study of renal damage mechanisms. Intravenous injection of rats with 0.4 mg/kg of Bothrops jararaca venom produced functional and morphologic changes similar to those observed in human snakebite-induced ARF. There was an acute and significant decrease in the glomerular filtration rate, diuresis, and renal plasma flow. Serum fibrinogen levels ...
Tópico(s): Rabies epidemiology and control
1993 - American Society of Tropical Medicine and Hygiene | American Journal of Tropical Medicine and Hygiene
Produção Nacional
Revisado por pares
Elson Luiz Fava, Tiago Almeida Silva, Thiago Martimiano do Prado, Fernando C. Moraes, Ronaldo C. Faria, Orlando Fatibello‐Filho,
A disposable microfluidic electrochemical paper-based device for multiplexed analysis based on sixteen independent microfluidic channels with electrochemical detection is proposed. A major advantage of this work was the non-necessary use of a wax printer for devices manufacturing which has a high cost of operation. In addition, a commercial multiplexing module was used that has the multiplexing capability of 8-16 channels and, for the first time using this module, the strategy of multiplexing both ...
Tópico(s): Electrochemical sensors and biosensors
2019 - Elsevier BV | Talanta
Produção Nacional
Revisado por pares
Adriana Dourado Rueda, José Luiz Pedroso, Eveli Truksinas, Gilmar Fernandes do Prado, Fernando Morgadinho Santos Coelho, Orlando Graziani Póvoas Barsottini,
Summary Spinocerebellar ataxia type 6 ( SCA 6) is usually described as a pure ataxia syndrome. However, SCA 6 patients may have sleep complaints. In this paper, sleep disorders were investigated in patients with SCA 6. Twelve SCA 6 patients and 12 subjects matched by gender, age and body mass index (control group) underwent polysomnography and clinical investigation for sleep disorders. SCA 6 had a higher frequency of snoring ( P = 0.01), a higher index of awakening due to respiratory events ( P = 0.003) and ...
Tópico(s): Sleep and Wakefulness Research
2016 - Wiley | Journal of Sleep Research
Produção Nacional
Revisado por pares
Lucas Debatin Vieira, Anderson Camargo Moreira, Iara Frangiotti Mantovani, Alisson Rech Honorato, Orlando Faria Prado, M.R O.C. Assis R.R.P. Alv Becker, Celso Peres Fernandes, Breno Leitão Waichel,
The porosity of volcanic rocks can be strongly affected by secondary processes such as the percolation of water and hydrothermal fluids, thus promoting crystallization of secondary minerals in the pores. With an aim to evaluate the impact of secondary mineral fillings, this paper shows the segmentation of secondary and filled pores based on the micro-CT technique. The mineralogy of the sample was analyzed with optical microscopy. Multiscale analysis was performed to determine the total porosity ...
Tópico(s): Mineral Processing and Grinding
2021 - Elsevier BV | Applied Radiation and Isotopes