Produção Nacional
Edna Teruko Kimura, Sílvia E. Matsuo, Julio C. Ricarte‐Filho,
... através da fosforilação das proteínas R-SMADs (SMAD 2/3) e co-SMADs (SMAD4). O controle apropriado da via de TGFbeta/activina ainda depende da regulação negativa exercida pelo SMAD inibitório (SMAD7) e pelas enzimas E3 de ubiquitinação (Smurfs). Fisiologicamente, TGFbeta e activina atuam como potentes inibidores ...
Tópico(s): Hedgehog Signaling Pathway Studies
2007 - Editora da Universidade de São Paulo | Arquivos Brasileiros de Endocrinologia & Metabologia
Fee Klupp, CHARLES O. GIESE, Christoph Kahlert, Niels Halama, Clemens M. Franz, Troy Schmidt, Felix Lasitschka, Arne Warth, M Schneider, Alexis Ulrich,
Einleitung: Smurf2 (Smad ubiquitination regulatory factor 2) ist ein Mitglied der HECT-Familie der E3 Ubiquitin-Ligasen. Veränderungen in ihrem Expressionsmuster tragen zur Tumorigenese bei. Smurf2 spielt eine entscheidende Rolle in der Zelldifferenzierung, -proliferation und -migration und hat sowohl onkogene als auch tumorsuppressive Eigenschaften. Bisher sind Veränderungen in der Expression von Smurf2 in verschiedenen Karzinomentitäten beschrieben. Die Rolle von Smurf2 bei Patienten mit Kolorektalem ...
Tópico(s): TGF-β signaling in diseases
2016 - Thieme Medical Publishers (Germany) | Zeitschrift für Gastroenterologie
Chie Suzuki, Gyo Murakami, Minoru Fukuchi, Tomomasa Shimanuki, Yuko Shikauchi, Takeshi Imamura, Kohei Miyazono,
... regulated 4 (Nedd4) and Smad ubiquitin regulatory factor (Smurf) family proteins represent the HECT-type subclass of ... induce translocation of Smad7 to the cytoplasm. The Smurfs·Smad7 complexes then associate with TGF-β-type ... physically interact with I-Smads, Smad6 and Smad7. Smurfs induce nuclear export of Smad7, interact with the ... Text PDF PubMed Scopus (687) Google Scholar). Thus, Smurfs negatively regulate the Smad signaling pathways through interaction ... decapentaplegic pathway during development, suggesting critical roles for Smurf ubiquitin ligases in TGF-β superfamily signaling. Similar ...
Tópico(s): Renal and related cancers
2002 - Elsevier BV | Journal of Biological Chemistry
Yun‐Hye Jin, Eunjoo Jeon, Qinglin Li, Yong Hee Lee, Joong-Kook Choi, Wun‐Jae Kim, Kwang-Youl Lee, Suk‐Chul Bae,
... three lysine residues protects RUNX3 from ubiquitin ligase Smurf-mediated degradation. The extent of the acetylation is ... three lysine residues protects RUNX3 from ubiquitin ligase Smurf-mediated degradation. The extent of the acetylation is ... lysine residues can be targeted by ubiquitin ligase Smurfs, TGF-β appears to suppress RUNX3 ubiquitination and ... demonstrate previously unidentified links among p300, HDACs, and Smurf in controlling RUNX3 stabilization and degradation. Cell Culture— ... of RUNX3 (Fig. 5C). Acetylation Protects RUNX3 from Smurf-mediated Degradation—C-terminal truncation of RUNX3 was ...
Tópico(s): Ubiquitin and proteasome pathways
2004 - Elsevier BV | Journal of Biological Chemistry
Hiroyuki Kaneki, Ruolin Guo, Di Chen, Zhenqiang Yao, Edward M. Schwarz, Ying E. Zhang, Brendan F. Boyce, Lianping Xing,
... We hypothesized that TNF inhibits osteoblast function through Smurf-mediated Runx2 degradation. We treated C2C12 and 2T3 ... We hypothesized that TNF inhibits osteoblast function through Smurf-mediated Runx2 degradation. We treated C2C12 and 2T3 ... ligand; RT, reverse transcription; siRNA, small interfering RNA; Smurf, Smad ubiquitin regulatory factor; Tg, transgenic; TGF-β, ... the E3 ubiquitin ligase, Smad ubiquitin regulatory factor (Smurf)1, regulates osteoblast differentiation by promoting proteasomal degradation ...
Tópico(s): Bone and Joint Diseases
2005 - Elsevier BV | Journal of Biological Chemistry
Stephen T. Vernon, Thomas Hansen, Katharine A. Kott, Jean Yang, John O’Sullivan, Gemma A. Figtree,
... of the four standard modifiable cardiovascular risk factors (SMuRFs)-diabetes mellitus, hyperlipidaemia, hypertension, and cigarette smoking-has ... conjunction with primary and secondary prevention strategies targeting SMuRFs to reduce the burden of CAD. Recent studies ... 25% of ACS patients do not have any SMuRFs. Thus, SMuRFs do not explain the entire burden of CAD. ...
Tópico(s): Computational Drug Discovery Methods
2018 - Wiley | Microcirculation
Manching Ku, Shavonne Howard, Weihua Ni, Giorgio Lagna, Akiko Hata,
... SBE, Smad-binding element; siRNA, small interference RNA; Smurf, Smad ubiquitination regulatory factor; TUNEL, terminal deoxynucleotidyl transferase- ... ubiquitin ligases known as Smad ubiquitination regulatory factor (Smurf)-1 and Smurf-2, resulting in receptor ubiquitination and degradation and ...
Tópico(s): Kruppel-like factors research
2005 - Elsevier BV | Journal of Biological Chemistry
Yoshiko Nagano, Konstantinos J. Mavrakis, Kian Leong Lee, Tomoko Fujii, Daizo Koinuma, Hitoshi Sase, Keiko Yuki, Kazunobu Isogaya, Masao Saitoh, Takeshi Imamura, Vasso Episkopou, Kohei Miyazono, Keiji Miyazawa,
... used are: TGF-β, transforming growth factor-β; Smurf, Smad ubiquitin regulatory factor; HDACs, histone deacetylases; CBP, ... is translocated to the plasma membrane in a Smurf (Smad ubiquitin regulatory factor) 1/2-dependent fashion ( ...
Tópico(s): NF-κB Signaling Pathways
2007 - Elsevier BV | Journal of Biological Chemistry
Sreedhara Sangadala, Scott D. Boden, Manjula Viggeswarapu, Yunshan Liu, Louisa Titus,
... or TBST buffer. The blots were incubated with Smurf antibody at 1:5000 dilution (rabbit antibody raised ... We next determined that LMP-1 protein inhibits Smurf WW domain antibody from binding to Smurf1, suggesting ...
Tópico(s): Connective tissue disorders research
2006 - Elsevier BV | Journal of Biological Chemistry
Mengge Du, Fan Liu, Yan Chang, Shuai Tong, Wei Liu, Yujiao Chen, Ping Xie,
... J.L. Regulation of planar cell polarity by Smurf ubiquitin ligases.Cell. 2009; 137: 295-307Abstract Full ... The Nedd8 non-covalent binding region in the Smurf HECT domain is critical to its ubiquitn ligase ...
Tópico(s): Cancer-related gene regulation
2021 - Elsevier BV | Journal of Biological Chemistry
Steven A. Johnsen, Malayannan Subramaniam, David G. Monroe, Ralf Janknecht, Thomas C. Spelsberg,
... Smad2 and the Smad ubiquitination regulatory factor-2 (Smurf-2), an E3 ubiquitin ligase, and results in ...
Tópico(s): Kruppel-like factors research
2002 - Elsevier BV | Journal of Biological Chemistry
Ming Zhao, Mei Qiao, Babatunde O. Oyajobi, Gregory R. Mundy, Di Chen,
... formation in vivo. It has been shown that Smurf mutations in Drosophila lead to enhanced decapentaplegic (a ...
Tópico(s): Bone health and treatments
2003 - Elsevier BV | Journal of Biological Chemistry
Teresita Bellido, Arshad Ali, Lilian I. Plotkin, Qiang Fu, Igor Gubrij, Paula K. Roberson, Robert S. Weinstein, Charles A. O’Brien, Stavros C. Manolagas, Robert L. Jilka,
... at San Antonio); wt Smad ubiquitin regulatory factor (Smurf) 1 and dn Smurf1 from G. Thomsen (Stony ...
Tópico(s): NF-κB Signaling Pathways
2003 - Elsevier BV | Journal of Biological Chemistry
Alessandra Magnifico, Seth A. Ettenberg, Cuihong Yang, Jennifer Mariano, Swati Tiwari, Shengyun Fang, Stan Lipkowitz, Allan M. Weissman,
... E3s that share significant homology with these include SMURF-1 and -2, which are involved in degradation ...
Tópico(s): Genetics and Neurodevelopmental Disorders
2003 - Elsevier BV | Journal of Biological Chemistry
Amjad Javed, Jong-Sup Bae, Faiza Afzal, Soraya Gutiérrez, Jitesh Pratap, Sayyed K. Zaidi, Yang Lou, André J. van Wijnen, Janet L. Stein, Gary S. Stein, Jane B. Lian,
... with binding sites for SMAD ubiquitination-related factor (SMURF) ubiquitin ligases, and phosphorylation sites for several classes ...
Tópico(s): Bone health and treatments
2008 - Elsevier BV | Journal of Biological Chemistry
Nadiya M. Teplyuk, Mario Galindo, Viktor I. Teplyuk, Jitesh Pratap, Daniel Young, David Lapointe, Amjad Javed, Janet L. Stein, Jane B. Lian, Gary S. Stein, André J. van Wijnen,
... other WW domain-containing proteins (e.g. TAZ, SMURF, and SCHNURRI) that all recognize a PPYP motif ...
Tópico(s): Cytokine Signaling Pathways and Interactions
2008 - Elsevier BV | Journal of Biological Chemistry
Hyung Cheol Kim, Alanna M Steffen, Michael L. Oldham, Jue Chen, Jon M. Huibregtse,
... JL (2010) The ubiquitin binding region of the Smurf HECT domain facilitates polyubiquitylation and binding of ubiquitylated ...
Tópico(s): Glycosylation and Glycoproteins Research
2011 - Springer Nature | EMBO Reports
T HOOPMAN, G. G. Birch, S. Serghat, Marie O. Portmann, M. Mathlouthi,
... using a sensory measuring unit for recording flux (SMURF) device. In all cases sweetness intensity and persistence ...
Tópico(s): Analytical Chemistry and Chromatography
1993 - Elsevier BV | Food Chemistry
Libing Feng, Susana Guedes, Tongwen Wang,
... as shown to be the case for the Smurfs (27Zhu H. Kavsak P. Abdollah S. Wrana J. ...
Tópico(s): Wnt/β-catenin signaling in development and cancer
2004 - Elsevier BV | Journal of Biological Chemistry
Ekaterina Pak, Rosalind A. Segal,
... T. Zhang Y.E. et al.Requirement of Smurf-mediated endocytosis of patched1 in sonic hedgehog signal ...
Tópico(s): Epigenetics and DNA Methylation
2016 - Elsevier BV | Developmental Cell
Yang Jia, Meng Wang, Yagang Wang,
... attributes in x, 41 features and a label. Smurf is the label of the record x. First ...
Tópico(s): Internet Traffic Analysis and Secure E-voting
2018 - Institution of Engineering and Technology | IET Information Security
Yana Xu, Meiyu Qu, Yangxun He, Qiangqiang He, Tingyu Shen, Jiahao Luo, Dan Tan, Hangyang Bao, Chengyun Xu, Xing Ji, Xinhua Hu, Muhammad Qasim Barkat, Linghui Zeng, Ximei Wu,
... invasion (17Koganti P. Levy-Cohen G. Blank M. Smurfs in protein homeostasis, signaling, and cancer.Front. Oncol. ... X. Zhang L. The functions and regulation of Smurfs in cancers.Semin. Cancer Biol. 2020; 67: 102- ... X. Zhang L. The functions and regulation of Smurfs in cancers.Semin. Cancer Biol. 2020; 67: 102- ...
Tópico(s): Hippo pathway signaling and YAP/TAZ
2023 - Elsevier BV | Journal of Biological Chemistry
Guillaume Roger, Grégory Ducrocq, Jules Mesnier, Neila Sayah, Jérémie Abtan, Roberto Ferrari, Ian Ford, Kim Fox, Jean‐Claude Tardif, Michał Tendera, Laurent J. Feldman, Yedid Elbez, Philippe Gabríel Steg, Philippe Gabríel Steg, Roberto Ferrari, Ian Ford, Kim Fox, Jean‐Claude Tardif, Michał Tendera, Fernando Sökn, Christopher M. Reid, Iréne Lang, F. Van Den Branden, Luis Machado César, Nazar Luqman, Assen Goudev, Paul Dorian, Dayi Hu, Petr Widimský, Christian Hassager, Nicolas Danchin, Stefan Kääb, Panos Vardas, Kadhim Sulaiman, Wael Al Mahmeed, Jassim Al Suwaidi, Ibrahim Al Rashdan, Fuad Abdulkader, Béla Merkely, Upendra Kaul, Kieran Daly, Luigi Tavazzi, Roberto Ferrari, Yangsoo Jang, Andrejs Ērglis, Aleksandras Laucevičius, Ahmad Nizar Jamaluddin, Marco Alcocer Gamba, Igor I. Tulevski, Janina Stępińska, Jońo Morais, Cezar Macarie, Р. Г. Оганов, S. А. Shalnova, Muayed Al‐Zaibag, Mak Koon Hou, Assoc Gabriel Kamensky, Zlatko Fras, Vojko Kanič, D.P. Naidoo, José Luis Zamorano, Hans Rickli, Andres Jaussi, Assoc Charn Sriratanasathavorn, Paul R. Kalra, Mykhailo Lutai, Oleksandr Parkhomenko, Lan Viet Nguyen, Ronald M.A. Henry, Andrea A Guerrero, Michael L. Basara, Fernando Belcastro, J A Bertarini, C Cazenave, H Dreycopp, J. Egido, Jeannelyn S. Estrella, Diana C. Garofalo, Jennifer Giordano, H Lagioia, Nieves Martínez Lago, R La Greca, Leonor Varela Lema, Néstor López-Cabanillas, Hugo A Luquez, Chad Miller, Elena Prada, Paloma Albacete Ródenas, R G Schena, G Suárez, Alejandro Tomatti, David Colquhoun, A. Conradie, Shanice Cox, Deanna Cross, Robert Fathi, B. Fitzgerald, Ian Hamilton‐Craig, Geoff Holt, Sakunthala Jayasinghe, N Mai, Johan A. Moolman, R. Motyer, Katherine W. Phillips, Anthony Rafter, A. Rahman, A. Rainbird, G. Scalia, Addison A. Taylor, Patrick West, Kevin Alford, R. Amor, P Astridge, Boris C. Bastian, Frank S. Bates, M. Doohan, J Du Plooy, Janet Ford, Lukshe Kanagaratnam, Vincent Khoury, Rebecca Parkin, Jennifer K. Rogers, G Sceats, Amy Waldman, D Wang, Sally Wright, JES Ardill, Philip E. Aylward, John F. Beltrame, Julie A. Bradley, William Heddle, Matthew Joseph, S. Rajendran, S Varughese, Edmund Brice, Bernard E.F. Hockings, Judith Janssen, Antoni Kozłowski, Joyce E O’Shea, Jonathan T. Tan, David Playford, Keith V Woollard, A. Ajani, Gemma A. Barron, Nathan Better, Thomas N. Carruthers, B. Chan, Ruth Chan, Joseph V. Cotroneo, J. Counsell, D. Eccleston, Brett H Forge, A. J. Hamer, Mark Horrigan, V. Michael Jelinek, Raymond Lew, D O'Donnell, Fabio Panetta, Martin Sebastian, Prakash Shetty, Alan Soward, Piyush Srivastava, N. Strathmore, S. Sylivris, G. Szto, V Veth, Terence Yip, Roza Badr-Eslam, Lucas Kleemann, Günther Steurer, B Mörz-Proszowski, F Auhser, U Teleky, G Sepp, A dreas Beinhauer, Darko Kero, C Lavicka, Teodora Perger, V Hadjiivanov, M Feldner-Busztin, R Mika, Wioleta Filip, Alfred Mahr, J Toplak, M G Millauer, P Haralambus, K Walcher, K H Karner, E Ziak, P Painsipp, Ulrich Frank, ANTON SUNTINGER, Walter Gritsch, G. Bode, Rolf Herrmann, R Raffelsberger, Hg Topf, E. C. Moser, J Föchterle, T Honsig, Karl Mayr, Harald Mayr, R Kaserbacher, Alexander Dzien, E Galehr, M Felbermayer, R Schwarz, Rose‐Marie Amini, H Appeltants, A Ballet, Clémence Niel, Guy Berkenboom, Xavier Bernard, T. Bouvy, Mathias Claeys, Y. Dascotte, Laurent Davin, T De Backer, A. De Meester, S. de Ridder, Paul Dendale, K Denef, Marieke Emonts, J T M Geraedts, Marc Goethals, J.M. Grégoire, T Herbots, E Hoffer, W. Hutse, Patrick R. LaFontaine, Philippe Lefèbvre, H Lesseliers, G Odent, A. Pasquet, Béatrice Peperstraete, Philippe Purnode, A Rogowsky, Michaël Rosseel, J. Salembier, P Surmont, A Vandeplas, Steven Van de Walle, F. Van Den Branden, Peter Vandergoten, B. Vanhauwaert, Lies Vanneste, J Vercammen, Dirk Verleyen, D Vermander, C Weytjens, Andrea De Lorenzo, A Felice Castro Issa, Bruno Mahler Mioto, C de Brito Vianna, C Okawabata, Elisa Rossi, F Fernandes, Felipe Arriva Pitella, Fernando Henpin Yue Cesena, Jennifer Ferreira, J F, L Tonet, L Machado Cesar, Luís Henrique Wolff Gowdak, Marcos André de Matos, M Moretti, Reynaldo Vicente Amato, R Tadeu Munhoz, Silmara Regina Coimbra, Andrea De Lorenzo, A Felice Castro Issa, Bruno Mahler Mioto, C de Brito Vianna, C Okawabata, Elisa Rossi, F Fernandes, Felipe Arriva Pitella, Fernando Henpin Yue Cesena, Jennifer Ferreira, J F, L Tonet, L Machado Cesar, Luís Henrique Wolff Gowdak, Marcos André de Matos, M Moretti, Reynaldo Vicente Amato, R Tadeu Munhoz, Silmara Regina Coimbra, Hajra Luqman, S Yakovova, M Mantcheva, Valentina M Mincheva, L. Baurenski, K Karastanev, V. Yordanova, Y Peneva,
... patients without standard modifiable cardiovascular (CV) risk factors (SMuRFs—diabetes, dyslipidaemia, hypertension, and smoking) presenting with first ... aims to explore the long-term outcomes of SMuRF-less patients with stable coronary artery disease (CAD). ... and clinical outcomes of patients with and without SMuRFs were compared. The primary outcome was a composite ... factor and outcome information, 977 (4.4%) were SMuRF-less. Age, sex, and time since CAD diagnosis were similar across groups. SMuRF-less patients had a lower 5-year rate ...
Oxford University Press
Ion S. Jovin, Edward O. McFalls,
... of management of the standard modifiable risk factors (SMuRFs) such as diabetes, hypertension, smoking, and hyperlipidemia. Although ... of patients presenting with a STEMI have no SMuRFs and have been referred to as SMuRF-less patients. Unfortunately, these patients seem to have ... noncardiovascular outcomes than patients with 1 or more SMuRFs. 2 Figtree GA Vernon ST Hadziosmanovic N Sundström ...
Tópico(s): Cardiac Health and Mental Health
2023 - Elsevier BV | The American Journal of Cardiology
Kaiyue Ma, Shushu Huang, Kenneth Ng, Nicole J. Lake, Soumya Joseph, J. Xu, Angela Lek, Lin Ge, Keryn G. Woodman, Katherine Koczwara, Justin Cohen, Vincent Ho, Christine O’Connor, Melinda A. Brindley, Kevin P. Campbell, Monkol Lek,
... genes. Our framework, saturation mutagenesis-reinforced functional assays (SMuRF), offers simple and cost-effective saturation mutagenesis paired ... to enhance the interpretation of unresolved variants. Applying SMuRF to neuromuscular disease genes FKRP and LARGE1, we ... in resolving clinically reported variants of uncertain significance. SMuRF also demonstrates utility in predicting disease severity, resolving ...
Tópico(s): Genetics and Neurodevelopmental Disorders
2024 - Cell Press | Cell
Akihiro Takasaki, Tairo Kurita, T Takeuchi, Takashi Omura, Jun Masuda, Tetsuya Seko, Tatsuhiko Tanigawa, Τakeshi Kitamura, Hitoshi Kakimoto, Kaoru Dohi,
... smoking are recognized as standard modifiable risk factors (SMuRFs) for adverse cardiovascular events such as acute myocardial ... Recent studies have shown that AMI patients without SMuRFs are associated with increased mortality compared to those with SMuRFs. However, the relationship between the number of SMuRFs in patients with AMI and mortality has not ... of AMI patients stratified by the number of SMuRFs. Methods We studied 6,706 AMI patients between ... in AMI patients stratified by the number of SMuRFs as the primary outcome. In addition, all-cause ...
Tópico(s): Healthcare Systems and Public Health
2024 - Oxford University Press | European Heart Journal
Javeria Jamal, Hanan Idris, A. Faour, Wesley Yang, Alison McLean, S. Burgess, I. Shugman, Aiden O’Loughlin, Dominic Y. Leung, C. Mussap, C. Juergens, S. Lo, J. French,
... the absence of standard modifiable cardiovascular risk factors (SMuRFs; smoking, hypertension, hypercholesterolemia, diabetes) have poorer outcomes compared to those with atleast one SMuRF. It has been hypothesised that this may be ... low risk. Long term outcomes of patients without SMuRFs based on reperfusion strategy received during the index ... clinical outcomes of STEMI patients with and without SMuRFs based on reperfusion strategy received during the index ... Late clinical outcomes of patients with and without SMuRFs were analysed overall and based on reperfusion strategy [ ...
Tópico(s): Heart rate and cardiovascular health
2022 - Oxford University Press | European Heart Journal
Anfal Hamza, Muhammad Khalid Razaq, Ghulam Mustafa, Umair J. Chaudhary, Ali Ayan, Bismillah Sehar,
Standard Modifiable Cardiovascular Risk Factors (SMuRF) like smoking and hypertension, Diabetes Mellitus, and dyslipidaemias, studies reveal a concerning trend: an increasing incidence of ST-elevation myocardial infarction ( ... patients with Standard Modifiable Cardiovascular Risk Factors as SMuRFs and without Standard Modifiable Cardiovascular Risk Factors as ... illustrate this phenomenon.2,3,4 STEMI without SMuRF was more common in younger patients with a ... Family History of Coronary Artery Disease and without SMuRF exhibited a predominant Multi Vessel Coronary Artery Disease ...
Tópico(s): Lipoproteins and Cardiovascular Health
2024 - Royal College of Physicians | Clinical Medicine
Como e que uma brincadeira de miudos, chamada smurfs, que chegou a Franca vinda dos Estados-Unidos ...
Tópico(s): Cultural, Media, and Literary Studies
2019 - University of Porto | Todas as Artes Revista Luso-Brasileira de Artes e Cultura
... through a presentation of standard modifiable CV factors (SMuRFs) [ [2] Shrestha B. Mochon A. Poudel B. Poudel ... hospital outcomes in patients with an absence of SMuRFs [ [3] Ando T. Akintoye E. Adegbala O. Ashraf ... with poor clinical outcome in an absence of SMuRFs versus those with SMuRFs were younger, more likely men with underweight (body ... other data indicate that this vulnerable population of SMuRF-less STEMI / AMI patients composed of rather white ... Google Scholar ]. Yet, some authors noticed that among SMuRF-less STEMI patients percutaneous coronary interventions (PCI) were ...
Tópico(s): Cardiac Health and Mental Health
2022 - Elsevier BV | International Journal of Cardiology