Amina Zedan, Mohamed I. Sakran, Omar Bahattab, Yousef M. Hawsawi, Osama M. Al‐Amer, Atif Abdulwahab A. Oyouni, Samah Nasr Eldeen, Mohammed A. El‐Magd,
The use of insects as a feasible and useful natural product resource is a novel and promising option in alternative medicine. Several components from insects and their larvae have been found to inhibit molecular pathways in different stages of cancer. This study aimed to analyze the effect of aqueous and alcoholic extracts of Vespa orientalis larvae on breast cancer MCF7 cells and investigate the underlying mechanisms. Our results showed that individual treatment with 5% aqueous or alcoholic larval ...
Tópico(s): Neurobiology and Insect Physiology Research
2021 - Multidisciplinary Digital Publishing Institute | Molecules
Syed Sameer Aga, Muhammad Anwar Khan, Mansour Qurashi, Bader Khawaji, Mubarak Al‐Μansour, Syed Waqas Shah, Amir Abushouk, Hassan Abdullah Alabdali, Ahmed Sultan Alharbi, Mishal Essam Hawsawi, Osama Ali Alzharani,
Dundee Ready Education Environment Measure (DREEM) inventory has been exhaustively used to evaluate the education environment (EE), especially in the health sector to identify the strengths and weaknesses of the program. This study was designed to investigate the medical students’ perceptions about the education environment (EE) of the College of Medicine (COM), Jeddah. This cross-sectional study was carried out on medical students and conducted between May and August 2020. A predesigned DREEM questionnaire ...
Tópico(s): Educational Environments and Student Outcomes
2021 - Hindawi Publishing Corporation | Education Research International
Rami B. Kassab, Ahmed A. Elhenawy, AbdulrahmanTheyab, Yousef M. Hawsawi, Osama M. Al‐Amer, Atif Abdulwahab A. Oyouni, Ola A. Habotta, Hussam A. Althagafi, Fahad Alharthi, Maha S. Lokman, Khalaf F. Alsharif, Ashraf Albrakati, Ali O. Al-Ghamdy, Ehab Kotb Elmahallawy, Mohamed Elhefny, Kalid E. Hassan, Alaa Jameel A. Albarakati, Ahmed E. Abdel Moneim, Ahmed A. Moustafa,
Tópico(s): Alcohol Consumption and Health Effects
2023 - Springer Science+Business Media | Environmental Science and Pollution Research
Ibrahim O. Alanazi, Jilani P. Shaik, Narasimha Reddy Parine, Nahla Azzam, Othman Alharbi, Yousef M. Hawsawi, Atif Abdulwahab A. Oyouni, Osama M. Al‐Amer, Faisal A. Alzahrani, Majid A. Almadi, Abdulrahman Aljebreen, Mohammad Saud Alanazi, Zahid Khan,
Background. Colorectal cancer (CRC) is a major health concern worldwide. A series of sequential accumulation of genetic and epigenetic changes are responsible for the initiation and progression of diseases via the normal > adenoma > carcinoma sequence. Genetic variants in crucial cancer-causing genes are known to mediate the risk of cancer. Objective. In this case-control study, we examined single nucleotide polymorphism (SNP) in HER1 (rs763317 and rs3752651) and HER2 (rs1136201 and rs1058808) genes to ...
Tópico(s): Gastric Cancer Management and Outcomes
2021 - Hindawi Publishing Corporation | Journal of Oncology
Mohammed A. El‐Magd, Ahmed Abdelfattah‐Hassan, Rasha A. Elsisy, Yousef M. Hawsawi, Atif Abdulwahab A. Oyouni, Osama M. Al‐Amer, Eman S. El‐Shetry,
The expression profile of early B-cell factor (Ebf) genes and loss of function experiments denote a crucial role for these genes during the late stage of skeletogenesis. However, little is known regarding the expression and function of these genes during the early stage of skeletogenesis. Therefore, this study aimed to detail the spatiotemporal expression pattern of cEbf1, in comparison to cEbf2 and cEbf3, in chick limb buds and investigate its function during chondrogenesis. cEbf1-3 were co-expressed ...
Tópico(s): TGF-β signaling in diseases
2021 - Elsevier BV | Gene
Yousef M. Hawsawi, Nouf S. Al‐Numair, Turki M. Sobahy, Areej M. Al‐Ajmi, Raneem M. Al‐Harbi, Mohammed Baghdadi, Atif Abdulwahab A. Oyouni, Osama M. Al‐Amer,
Abstract Background BRCA1/2 pathogenic variants have become associated with familial breast and ovarian cancers, and hereditary cancer‐predisposition syndrome. With advances in molecular biology, BRCA profiling facilitates early diagnosis and the implementation of preventive and therapeutic strategies. The genes exhibit variable prevalence among different individuals and moderate interpretation complexity. BRCA deficiency is instrumental in cancer development, affects therapeutic options and is ...
Tópico(s): CRISPR and Genetic Engineering
2019 - Wiley | Molecular Genetics & Genomic Medicine
Vidya Devanathadesikan Seshadri, Atif Abdulwahab A. Oyouni, Yousef MohammedRabaa Hawsawi, Saad Ali S. Aljohani, Osama M. Al‐Amer, Waseem AlZamzami, Ahmad H. Mufti,
Lung cancer (LC) is a foremost cause of cancer-associated mortalities worldwide and it causes 17 % of the total cancer incidences and 20 % of the cancer-associated mortalities annually. In this exploration, we intended to formulate the Tin oxide-Chitosan-Polyethylene glycol-Crocin nanocomposites (SCP-Cr-NCs) and examine its anticancer role against the LC in both in vitro and in vivo models. The formulated SCP-Cr-NCs were characterized using several methods. The LC was initiated to the BALB/c mice via ...
Tópico(s): Pomegranate: compositions and health benefits
2022 - Elsevier BV | Process Biochemistry
Yousef MohammedRabaa Hawsawi, Samar Zailaie, Atif Abdulwahab A. Oyouni, Othman R. Alzahrani, Osama M. Al‐Amer, Saad Ali S. Aljohani,
Abstract Prostate cancer (PC) is the most prevalent type of cancer in men worldwide. In Saudi Arabia, the rate of PC is increasing annually. The sex steroid hormones androgens and their receptors have critical roles in PC development and progression. Additionally, apoptosis-related proteins such as heat-shock proteins are vital molecules in PC development. Steroid hormone-deprivation therapies remain the essential treatment for patients with metastatic PCs; however, acquired resistance to hormone ...
Tópico(s): Xenotransplantation and immune response
2020 - Springer Science+Business Media | Journal of Biological Research - Thessaloniki
Faisal A. Alzahrani, Yousef M. Hawsawi, Hisham N. Altayeb, Naif Alsiwiehri, Othman R. Alzahrani, Hanan E. Alatwi, Osama M. Al‐Amer, Suliman Yousef Alomar, Lamjed Mansour,
Abstract Background Testis expressed 19 ( TEX19 ) is a specific human stem cell gene identified as cancer‐testis antigen (CTA), which emerged as a potential therapeutic drug target. TEX19.1, a mouse paralog of human TEX19, can interact with LINE‐1 retrotransposable element ORF1 protein (LIRE1) and subsequently restrict mobilization of LINE‐1 elements in the genome. Aim This study aimed to predict the interaction of TEX19 with LIRE1 and analyze TEX19 missense polymorphisms. TEX19 model was generated using ...
Tópico(s): Chromosomal and Genetic Variations
2021 - Wiley | Molecular Genetics & Genomic Medicine
Nouf S. Al‐Numair, Abdulrahman Theyab, Faisal A. Alzahrani, Anwar Shams, Ibrahim O. Alanazi, Atif Abdulwahab A. Oyouni, Osama M. Al‐Amer, Charalampos Mavromatis, Islam M. Saadeldin, Wed A. Abdali, Yousef MohammedRabaa Hawsawi,
Cancer is a major health concern and accounts for one of the main causes of death worldwide. Innovative strategies are needed to aid in the diagnosis and treatment of different types of cancers. Recently, there has been an evolving interest in utilizing nanobodies of camel origin as therapeutic tools against cancer. Nanotechnology uses nanobodies an emerging attractive field that provides promises to researchers in advancing different scientific sectors including medicine and oncology. Nanobodies ...
Tópico(s): Hepatitis B Virus Studies
2022 - BioMed Central | Cancer Cell International
Ibrahim Omar Barnawi, Yousef M. Hawsawi, Philip R. Dash, Atif Abdulwahab A. Oyouni, Syed Khalid Mustafa, Nahed Ahmed Hussien, Osama M. Al‐Amer, Suliman Yousef Alomar, Lamjed Mansour,
Despite the advancement in the fields of medical science and molecular biology, cancer is still the leading cause of death worldwide. Chemotherapy is a choice for treatment; however, the acquisition of chemoresistance is a major impediment for cancer management. Many mechanisms have been postulated regarding the acquisition of chemo-resistance in breast cancer and the impact on cellular signalling and the induction of apoptosis in tumour cells. The mechanism of the apoptotic mutation ofp53 and bcl- ...
Tópico(s): Bioactive Compounds and Antitumor Agents
2021 - Bentham Science Publishers | Anti-Cancer Agents in Medicinal Chemistry
Abdulelah Alanazi, Saad Alanazi, Anhar Alhamyani, Abdulhadi Alkhalifah, Amal Alsaif, Muath Sulaiman G. Alhamdi, Danh Alghamdi, Osama Alariany, Etedal Hawsawi, Abdulaziz Bawazeer, Raghad Alrasheedi, Hala Khashoggi,
Background: Surgical practice is constantly altering due to computer-assisted solutions. When it comes to computer-integrated surgical methods, augmented reality is one of the most innovative technologies. Although augmented reality is becoming more and more common in many medical fields, its use in orthopedic surgery is still unclear. This article aims to give a comprehensive overview of the state of the art and the potential applications of AR in orthopedic surgery. Method: A thorough study of ...
Tópico(s): Anatomy and Medical Technology
2023 - | International Journal of Medicine in Developing Countries
Othman R. Alzahrani, Hanan E. Alatwi, Amnah A. Alharbi, Abdulrahman H. Alessa, Osama M. Al‐Amer, Abeer F. R. Alanazi, Anwar Shams, Esra’a Alomari, Abdallah Y. Naser, Faisal A. Alzahrani, Salman Hosawi, Saeed M. Alghamdi, Wed A. Abdali, Imadeldin Elfaki, Yousef M. Hawsawi,
Background: Autosomal dominant polycystic kidney disease (ADPKD) is a condition usually caused by a single gene mutation and manifested by both renal and extrarenal features, eventually leading to end-stage renal disease (ESRD) by the median age of 60 years worldwide. Approximately 89% of ADPKD patients had either PKD1 or PKD2 gene mutations. The majority (85%) of the mutations are in the PKD1 gene, especially in the context of family history. Objectives: This study investigated the genetic basis and ...
Tópico(s): Renal cell carcinoma treatment
2022 - Multidisciplinary Digital Publishing Institute | Medicina
Nouf S. Al‐Numair, Abdulrahman Theyab, Faisal A. Alzahrani, Anwar Shams, Ibrahim O. Alanazi, Atif Abdulwahab A. Oyouni, Osama M. Al‐Amer, Charalampos Mavromatis, Islam M. Saadeldin, Wed A. Abdali, Yousef M. Hawsawi,
Tópico(s): Proteins in Food Systems
2023 - BioMed Central | Cancer Cell International
Osama Abdulaziz, Farhan R. Khan, Nahed S. Alharthi, Hayaa M. Alhuthali, Ali Hazazi, Hind A. Alzahrani, Amal F. Gharib, Ohud Alsalmi, Nahed M. Hawsawi, Abdulfattah Yahya M. Alhazmi,
In the present study, the formation of a heterodimer involving both epidermal growth factor receptor (EGFR) and human epidermal growth factor receptor 2 (HER2) has been explored as a potential therapeutic mechanism to inhibit the progression of breast cancer. Virtual screening using molecular docking resulted in the three hit compounds (ZINC08382411, ZINC08382438, and ZINC08382292) with minimum binding scores and commonly binding to both receptors. Further, MD simulation analysis of these complexes ...
Tópico(s): Monoclonal and Polyclonal Antibodies Research
2024 - Taylor & Francis | Journal of Biomolecular Structure and Dynamics
Sara Ahmed Hifny, Mohammed Abdulrazzag Hawsawi, Abdulaziz Mohammed Baraat, Wesam Faiz Bakhadlaq, Hafiz Mohammed Hakami, Abdullah Abdulghani Alghamdi, Homood Mohammed Alsayegh, Asmaa Tariq Ashour, Ahmed Abdullah Bahamid, Rehan Salem Alsalem, Shereen Osama Jiffri,
Traumatic dental injuries can significantly impact the appearance and the functions of the affected teeth and can induce significant damages to the surrounding structures within the oral cavity including both the soft and hard ones. This present literature review aimed to discuss the appropriate orthodontic management of dental traumatic events and to present evidence from previous studies in the literature. The search took place in the relevant databases l, such as PubMed, Web of Science, Scopus ...
Tópico(s): Dental Radiography and Imaging
2021 - Medip Academy | International Journal of Community Medicine and Public Health
Shaimaa M. Badr-Eldin, Hibah M. Aldawsari, Usama A. Fahmy, Osama A. A. Ahmed, Nabil A. Alhakamy, Mahmoud A. Elfaky, Alaa Sirwi, Salman A. Hawsawi, Ali H. Alzahrani, Abdulrahman Y. Yaseen, Mohannad Qassim, Sabna Kotta,
Fluconazole (FLZ) is the most widely used antifungal agent for treating cutaneous candidiasis. Although oral FLZ has been proved to be effective, the incidence of side effects necessitates the development of an effective formulation that could surpass the pitfalls associated with systemic availability. Accordingly, this research aimed at developing a self-assembled mixed micelles topical delivery system to enhance the topical delivery of the drug. Self-assembled mixed micelles were developed using ...
Tópico(s): Antifungal resistance and susceptibility
2022 - De Gruyter Open | Acta Pharmaceutica
Osama M. Al‐Amer, Rashid Mir, Abdullah Hamadi, Mohammed Alasseiri, Malik A. Altayar, Waseem AlZamzami, Mamdoh S. Moawadh, Sael Alatawi, Hanan A. Niaz, Atif Abdulwahab A. Oyouni, Othman R. Alzahrani, Hanan E. Alatwi, Aishah E. Albalawi, Khalaf F. Alsharif, Ashraf Albrakati, Yousef M. Hawsawi,
The findings of earlier investigations of antiapoptotic gene genotypes and allele variants on lymphoma risk are ambiguous. This study aimed to examine the relationship between the mutation in the antiapoptotic genes and lymphoma risk among Saudi patients.This case-control study included 205 patients, 100 of whom had lymphoma (cases) and 105 who were healthy volunteers (controls). We used tetra amplification refractory mutation polymerase chain reaction (PCR) to identify antiapoptotic genes such as ...
Tópico(s): Chronic Lymphocytic Leukemia Research
2023 - Multidisciplinary Digital Publishing Institute | Cancers