Matt Lechner, Yoko Takahashi, Mario Turri‐Zanoni, Jacklyn Liu, Nicholas Counsell, Mario Hermsen, Raman Preet Kaur, Tianna Zhao, Murugappan Ramanathan, Volker Hans Schartinger, Oscar Emanuel, Sam Helman, Jordan Varghese, József Dudás, Herbert Riechelmann, Susanne Sprung, Johannes Haybaeck, David Howard, Nils W. Engel, Sarah Stewart, Laura Brooks, Jessica C. Pickles, Thomas S. Jacques, Tim R. Fenton, Luke Williams, Francis Vaz, Paul O’Flynn, Paul Stimpson, Shih‐Yu Wang, S. Alam Hannan, Samit Unadkat, Jonathan Hughes, Raghav C. Dwivedi, Cillian T. Forde, Premjit S. Randhawa, Simon Gane, J. Joseph, Peter Andrews, Gary Royle, Alessandro Franchi, Roberta Maragliano, Simonetta Battocchio, Helen Bewicke‐Copley, Christodoulos P. Pipinikas, Amy P. Webster, Chrissie Thirlwell, Debbie L. L. Ho, Andrew E. Teschendorff, Tianyu Zhu, Christopher D. Steele, Nischalan Pillay, Bart Vanhaesebroeck, Ahmed Mohyeldin, Juan C. Fernandez‐Miranda, Ki Wan Park, Quynh‐Thu Le, Robert B. West, Rami Saade, R. Peter Manes, Sacit Bulent Omay, Eugenia M. Vining, Benjamin L. Judson, Wendell G. Yarbrough, Maddalena Sansovini, Silvia Nicolini, Ilaria Grassi, Alberto Bongiovanni, David Capper, Ulrich Schüller, Selvam Thavaraj, Ann Sandison, Pavol Šurda, Claire Hopkins, Marco Ferrari, Davide Mattavelli, Vittorio Rampinelli, Fabio Facchetti, Piero Nicolai, Paolo Bossi, Oswaldo A. Henriquez, Kelly R. Magliocca, C. Arturo Solares, Sarah K. Wise, José Luís Llorente, Zara M. Patel, Jayakar V. Nayak, Peter H. Hwang, Peter D. Lacy, Robbie Woods, James P. O’Neill, Amrita Jay, Dawn Carnell, Martin Förster, Masaru Ishii, Nyall R. London, Diana Bell, Gary L. Gallia, Paolo Castelnuovo, Stefano Severi, Valerie J. Lund, Ehab Y. Hanna,
Abstract Introduction Olfactory neuroblastoma (ONB) is a rare cancer of the sinonasal region. We provide a comprehensive analysis of this malignancy with molecular and clinical trial data on a subset of our cohort to report on the potential efficacy of somatostatin receptor 2 (SSTR2)-targeting imaging and therapy. Methods We conducted a retrospective analysis of 404 primary, locally recurrent, and metastatic olfactory neuroblastoma (ONB) patients from 12 institutions in the United States of America, United ...
Tópico(s): Ocular Oncology and Treatments
2021 - Elsevier BV | European Journal of Cancer
Andrew J. Steehler, Brian Pettitt‐Schieber, Matthew Studer, Geetha Mahendran, Barbara J. Pettitt, Oswaldo A. Henriquez,
Objective To develop and evaluate a virtual otolaryngology medical student elective created during the COVID‐19 crisis with the intention of teaching the basic tenets of otolaryngology and increasing exposure to the specialty. Study Design Cross‐sectional survey. Setting Emory University School of Medicine. Methods A 1‐week virtual otolaryngology curriculum was offered to third‐ and fourth‐year medical students that centered on the American Academy of Otolaryngology–Head and Neck Surgery Foundation’ ...
Tópico(s): Lymphadenopathy Diagnosis and Analysis
2020 - Wiley | Otolaryngology
Oswaldo A. Henriquez, Kyle A. Den Beste, Elizabeth K. Hoddeson, Charles A. Parkos, Asma Nusrat, Sarah K. Wise,
Epithelial permeability is highly dependent upon the integrity of tight junctions, which are cell-cell adhesion complexes located at the apical aspect of the lateral membrane of polarized epithelial cells. We hypothesize that sinonasal epithelial exposure to Der p 1 house dust mite antigen decreases expression of tight junction proteins (TJPs), representing a potential mechanism for increased permeability and presentation of antigens across the sinonasal epithelial layer.Confluent cultured primary ...
Tópico(s): Asthma and respiratory diseases
2013 - Wiley | International Forum of Allergy & Rhinology
Samuel L. Oyer, Jennifer K. Mulligan, Alkis J. Psaltis, Oswaldo A. Henriquez, Rodney J. Schlosser,
Objectives/Hypothesis Compare cytokine levels in sinus tissue to sinus secretions from controls and chronic rhinosinusitis patients. Study Design In vitro. Methods Polyurethane foam sponges were placed into middle meati of patients with chronic rhinosinusitis without nasal polyps (CRSsNP), with polyps (CRSwNP), and controls. Sinus biopsies were then taken from the same location. Protein levels of tumor necrosis factor‐alpha (TNF‐α), interferon‐γ (IFN‐γ), and interleukins (IL) 2, 4, 6, 8, 10, and 17A ...
Tópico(s): Allergic Rhinitis and Sensitization
2013 - Wiley | The Laryngoscope
Oswaldo A. Henriquez, Rodney J. Schlosser, Jess C. Mace, Timothy L. Smith, Zachary M. Soler,
Objectives/Hypothesis Synechiae are one of the most common unwanted outcomes after endoscopic sinus surgery (ESS) for chronic rhinosinusitis (CRS). However, there has been scant investigation into the true significance of synechiae formation after ESS. The aim of this study was to evaluate the impact of synechiae formation on health‐related quality of life (HRQoL) outcomes after ESS in patients with CRS. Study Design Prospective, multi‐institutional cohort. Methods Rhinosinusitis Disability Index (RSDI) ...
Tópico(s): Head and Neck Surgical Oncology
2013 - Wiley | The Laryngoscope
Craig Miller, Jeffrey D. Suh, Oswaldo A. Henriquez, Rodney J. Schlosser, Vijay R. Ramakrishnan, Alexander G. Chiu,
Background The abducens nerve, cranial nerve VI (CNVI), is the medial-most nerve in the cavernous sinus. Its close proximity to the sphenoid sinus makes it susceptible to injury, invasion, or compression from a sphenoid pathology leading to horizontal gaze diplopia. A wide range of literature describes myriad causes for CNVI palsy, but there is a lack of references that point to paranasal sinus pathology as an etiology, as well as the prognosis and timeline for resolution. Here, we describe a series ...
Tópico(s): Ophthalmology and Eye Disorders
2013 - SAGE Publishing | American Journal of Rhinology and Allergy
Alkis J. Psaltis, Rodney J. Schlosser, James R. Yawn, Oswaldo A. Henriquez, Jennifer K. Mulligan,
Background Recent research suggest that B and plasma cells may play an important role in the pathogenesis of chronic rhinosinusitis with nasal polyposis (CRSwNP). The purpose of this study was to subcharacterize the B cell response in the sinus mucosa of control and CRS patients. Methods Representative tissue samples and peripheral blood samples were obtained from controls, CRS without nasal polyps (CRSsNP) and CRSwNP. Using single‐cell suspension flow cytometry these samples were analyzed for overall ...
Tópico(s): Head and Neck Surgical Oncology
2013 - Wiley | International Forum of Allergy & Rhinology
Oswaldo A. Henriquez, Lindy Wolfenden, Arlene A. Stecenko, John M. DelGaudio, Sarah K. Wise,
To ascertain the effect of endoscopic sinus surgery (ESS) on lung function, intravenous (IV) antibiotic use, and hospitalization in adults with cystic fibrosis (CF).Retrospective analysis.Tertiary care center.Fifteen adults with a diagnosis of CF undergoing ESS between March 1, 2006, and June 31, 2008.Twelve-month preoperative and 12-month postoperative pulmonary function testing (forced vital capacity [FVC] and forced expired volume in 1 second [FEV1]), number of IV antibiotic courses, total number of ...
Tópico(s): Head and Neck Surgical Oncology
2012 - American Medical Association | Archives of Otolaryngology - Head and Neck Surgery
Vasantha L. Kolachala, Oswaldo A. Henriquez, Samantha Shams, Justin S. Golub, Young Tae Kim, Hamed Laroui, Edilson Torres‐Gonzalez, Kenneth L. Brigham, Mauricio Rojas, Ravi V. Bellamkonda, Michael M. Johns,
There is a need for a slow-release system for local delivery of therapeutics to the larynx. Most therapeutic substances, such as steroids or chemotherapeutic agents that are injected into the larynx are cleared rapidly. Repeated laryngeal injection of these substances at short intervals is impractical. Injectable encapsulated poly(lactide-co-glycolide) (PLGA) nanoparticles offer a potential slow-release delivery system for biologically active substances in the larynx.Controlled animal study.PLGA ...
Tópico(s): Dysphagia Assessment and Management
2010 - Wiley | The Laryngoscope
René Utrera, Vanessa K. Ridaura, Yuryanni Rodríguez, María José Contreras Rojas, Leomig Mago, Simón I. Angeli, Oswaldo A. Henriquez,
Severe to profound hearing impairment affects 1 of every 1000 newborn children each year. Inheritance accounts for 60% of these cases, of which 70% are nonsyndromic. The most common cause of autosomal recessive nonsyndromic hearing loss (ARNSHL) is mutation in GJB2, a gene on chromosome 13, which encodes a gap junction protein named Connexin 26. Mutations in GJB2 are responsible for 40% of genetic childhood deafness. The most common mutation, 35delG, predominates in many ethnic groups. Some families ...
Tópico(s): Neuroscience of respiration and sleep
2007 - Mary Ann Liebert, Inc. | Genetic Testing
Wael Abdelkafy, Johnathon Q Smith, Oswaldo A. Henriquez, Justin S. Golub, Jianguo Xu, Mauricio Rojas, Kenneth L. Brigham, Michael M. Johns,
Changes in voice are commonly associated with aging (presbyphonia). Age-related voice change significantly impairs elderly individuals' ability to communicate meaningfully with others and affects their quality of life. With changing age demographics in our society and increasing emphasis on quality of life, treatment of presbylaryngis is becoming more paramount.We used 9 aged and 9 young mice to validate a mouse model for the aging larynx. We stained the larynges with Alcian blue to determine the ...
Tópico(s): Cancer-related molecular mechanisms research
2007 - SAGE Publishing | Annals of Otology Rhinology & Laryngology
Simón I. Angeli, René Utrera, Samar Dib, Edgar Chiossone, C.M. Naranjo, Oswaldo A. Henriquez, Magdalena Porta,
The frequency of childhood deafness is estimated at 1:1,000 and at least half of these cases are genetic. Recently, mutations in the GJB2 gene have been found in a great number of familial and sporadic cases of congenital deafness in Caucasians. The most common mutation (70%) is the frameshift mutation of a single guanine in position 35 (35delG). More than 20 mutations in the GJB2 gene are associated with DFNB1, a prevalent type of autosomal recessive non-syndromic neurosensory deafness. Last year ...
Tópico(s): Connexins and lens biology
2000 - Taylor & Francis | Acta Oto-Laryngologica
Dina Amin, Kareem Al‐Mulki, Oswaldo A. Henriquez, Angela Cheng, Steven M. Roser, Shelly Abramowicz,
To perform a comprehensive review and analysis of surgically treated orbital fractures.Retrospective cohort chart review study for surgically treated orbital fractures during 5 years.A total of 173 patients (average age 41.6 years) were diagnosed with orbital fractures. Most were male with a ratio of 3.3:1. Most fractures were caused by assault (39.3%); 22.5% of the cases were bilateral. The left orbit (40.5%) was fractured more than the right. The orbital floor (97.1%) was the most common anatomic ...
Tópico(s): Dental Radiography and Imaging
2020 - SAGE Publishing | Craniomaxillofacial Trauma & Reconstruction
Eduardo J. Medina, J. Manuel Revuelta Barbero, Edoardo Porto, Tomás Garzón-Muvdi, Oswaldo A. Henriquez, C. Arturo Solares, Gustavo Pradilla,
... Porto, Edoardo MD*; Garzon-Muvdi, Tomas MD, MS*; Henriquez, Oswaldo MD‡; Solares, C. Arturo MD‡; Pradilla, Gustavo MD* ...
Tópico(s): Medical Imaging Techniques and Applications
2022 - Lippincott Williams & Wilkins | Operative Neurosurgery
Andrew J. Steehler, Samir A. Ballestas, Danielle Scarola, Oswaldo A. Henriquez, Charles E. Moore,
Our understanding of the novel coronavirus, COVID-19, is growing; yet, there remains much we do not understand, and unique presentations are abundant. One potential presentation is retropharyngeal edema, defined as fluid in the retropharyngeal space. Multiplanar imaging with computed tomography or magnetic resonance imaging is ideal for characterizing and diagnosing these fluid collections rapidly as possible life-threatening complications may develop (eg, airway obstruction and mediastinitis). Here, ...
Tópico(s): Tracheal and airway disorders
2020 - SAGE Publishing | Ear Nose & Throat Journal
Nefize Turan, Griffin R. Baum, Christopher M. Holland, Faiz U. Ahmad, Oswaldo A. Henriquez, Gustavo Pradilla,
Background Cholesterol granulomas arising at the petrous apex can be treated via traditional open surgical, endoscopic, and endoscopic-assisted approaches. Endoscopic approaches require access to the sphenoid sinus, which is technically challenging in patients with conchal sphenoidal anatomy. Clinical Presentation A 55-year-old woman presented with intermittent headaches and tinnitus. Formal audiometry demonstrated moderately severe bilateral hearing loss. CT of the temporal bones and sella revealed a well- ...
Tópico(s): Ear and Head Tumors
2015 - Thieme Medical Publishers (Germany) | Journal of Neurological Surgery Reports
J. Manuel Revuelta Barbero, Roberto M. Soriano, David P. Bray, Rima S. Rindler, Oswaldo A. Henriquez, C. Arturo Solares, Gustavo Pradilla,
The objective of the present study was to describe and evaluate the feasibility, mobility, and surface area provided by the simple and extended transorbital pericranial flap (TOPF). Furthermore, we compared this novel technique with the current practice of pericranial flap harvesting and insetting techniques. We also studied the adequacy of the TOPF in the reconstruction of postoperative anterior cranial fossa (ACF) defects.The TOPF was performed bilaterally in 5 alcohol-preserved, latex-injected ...
Tópico(s): Craniofacial Disorders and Treatments
2021 - Elsevier BV | World Neurosurgery
Osvaldo Larrazábal Henríquez, Oswaldo Larrazábal Henriquez,
Cuando Roinulo Gallegos public' su primera novela, El iiltimo Solar (Reinaldo Solar),l en 1920, comenzo a implementar, literariamente, todo un cuimulo de ideas que habia venido manejando y madurando a lo largo de sus tareas docentes, de sus intervenciones como ensayista en la revista Alborada y, sobre todo, en el intercambio de opiniones y de experiencias al lado del reducido grupo de amigos que constituyo la celebre agrupacion que a comienzos de este siglo culmino con la publicacion de la revista ...
Tópico(s): Spanish Literature and Culture Studies
1980 - Tufts University | Revista de Crítica Literaria Latinoamericana
Scott M. Russell, Lindsey Highsmith, Samir Belagaje, Oswaldo A. Henriquez, Charles E. Moore,
Background/Aims Patients in acute care who have received a tracheotomy require efficient management to adequately progress through the acute care setting. This progression is predicated on efficient tracheostomy weaning through tracheostomy downsizing, capping and decannulation. The objective of this retrospective study was to review the outcomes of tracheostomy tube changes by speech-language pathologists. Methods A retrospective cohort analysis was performed of adult patients who received a tracheostomy ...
Tópico(s): Esophageal and GI Pathology
2024 - Mark Allen Group | International Journal of Therapy and Rehabilitation
Brian P. Hall, J. Anderson, Clementino Solares Rivera, Oswaldo A. Henriquez, John M. DelGaudio, Mark W. McDonald, Kelly R. Magliocca,
Background: Biphenotypic sinonasal sarcoma (BSNS) is an extremely rare malignancy with limited clinical experience or data on treatment outcomes. This descriptive series reports clinicopathological characteristics and treatment outcomes of a series of patients with BSNS evaluated and/or treated at our institution.
Tópico(s): Microbial infections and disease research
2024 - Thieme Medical Publishers (Germany) | Journal of Neurological Surgery Part B Skull Base
Edoardo Porto, J. Manuel Revuelta Barbero, Hanyao Sun, John M. DelGaudio, Oswaldo A. Henriquez, Gabriel Zada, Emily Barrow, C. Arturo Solares, Tomas Garzon Muvdi, Gustavo Pradilla,
Background: Internal carotid artery injury (ICAI) represents one of the most challenging complications in endoscopic endonasal neurosurgery (EEN) and its rarity results in limited opportunities for trainees and surgeons to achieve proficiency in its management. Currently, available models for ICAI have employed costly systems that prevent their widespread use.
Tópico(s): Cerebrovascular and Carotid Artery Diseases
2023 - Thieme Medical Publishers (Germany) | Journal of Neurological Surgery Part B Skull Base
Edoardo Porto, J. Manuel Revuelta Barbero, Hanyao Sun, Justin Maldonado, Alejandra Rodas, John M. DelGaudio, Oswaldo A. Henriquez, Emily Barrow, Gabriel Zada, C. Arturo Solares, Tomás Garzón-Muvdi, Gustavo Pradilla,
Internal carotid artery injury (ICAI) represents one of the most challenging complications in endoscopic endonasal neurosurgery and its rarity results in limited opportunities for trainees and surgeons to achieve proficiency in its management. Currently, available models for ICAI have employed costly systems that prevent their widespread use. The objective of this study is to validate an affordable submersible peristaltic pump (SPP)-based model as a reproducible and realistic paradigm for ICAI management ...
Tópico(s): Intracranial Aneurysms: Treatment and Complications
2022 - Elsevier BV | World Neurosurgery
Scott M. Russell, Lindsey Highsmith, Oswaldo A. Henriquez, Samir Belagaje, Charles E. Moore,
Background/Aims: The number of tracheostomised patients in the acute care setting are increasing, resulting in an equal need of providers who can safely change tracheostomy tubes without complications. The objective of this retrospective study was to ascertain if trained speech-language pathologists were able to safely and efficiently perform tracheostomy tube changes in the acute care setting with minimal adverse events. Methods: Our retrospective case series spans from June 2010 to March 2015 ...
Tópico(s): Trauma Management and Diagnosis
2017 - Mark Allen Group | International Journal of Therapy and Rehabilitation
Lluı́s Samaranch, Oswaldo Lorenzo‐Betancor, José Matías Arbelo, Isidró Ferrer, Elena Lorenzo, Jaione Irigoyen, María A. Pastor, Carmen Marrero, Concepción Isla, Joanna Herrera-Henriquez, Pau Pástor,
Phosphatase and tensin homolog-induced putative kinase 1 gene mutations have been associated with autosomal recessive early-onset Parkinson's disease. To date, no neuropathological reports have been published from patients with Parkinson's disease with both phosphatase and tensin homolog-induced putative kinase 1 gene copies mutated. We analysed the coding region of phosphatase and tensin homolog-induced putative kinase 1 gene in a large Spanish family with six members with parkinsonism. The phenotype ...
Tópico(s): Cellular transport and secretion
2010 - Oxford University Press | Brain
Marvin Goldstein, Julia Choate Roslaniec, James D. Gallup, Peter Medawar, Sandor J. Woren, Oswaldo Henriquez,
Tópico(s): Veterinary Practice and Education Studies
1976 - Taylor & Francis | Hospital Practice
Alexandrea Kim, Anthony Botros, Oswaldo A. Henriquez,
This article provides a review of the current technologies available in the preoperative and intraoperative management of complex and secondary maxillofacial trauma reconstruction. These patients present a unique challenge for which the advancement of imaging technologies, patient-specific modeling and implants, and intraoperative imaging and navigation can play an important role to improve their post-treatment outcomes.
Tópico(s): Spinal Fractures and Fixation Techniques
2023 - Elsevier BV | Otolaryngologic Clinics of North America
Alexandros Georgolios, Oswaldo A. Henriquez,
"International Medical Graduates" (IMGs) make up a large percentage of "underrepresented in medicine" physicians and comprise 25% of the US physician workforce. The American Academy of Otolaryngology-Head and Neck Surgery, in its "Statement on Diversity," has expressed its enduring commitment to inclusion and diversity in all its forms. However, unlike various other specialties, a discussion about integration of IMGs in Otolaryngology has not been raised in our community. This commentary reviews the ...
Tópico(s): Surgical Simulation and Training
2023 - Wiley | Otolaryngology
J. Manuel Revuelta Barbero, Roberto M. Soriano, Edoardo Porto, David P. Bray, Emily Barrow, Oswaldo A. Henriquez, C. Arturo Solares, Gustavo Pradilla,
Background/objective In this radioanatomical study with clinical correlate, we study a variation of the ‘extended nasal floor mucosa’ (ENFM) free-graft, the purely nasal floor mucosa (PuNFM) free-graft. The objectives of this study are to evaluate the coverage surface area provided by the PuNFM, study the adequacy of the PuNFM in the reconstruction of endoscopic endonasal approach (EEA) transsellar postoperative defects and compare and evaluate this reconstructive technique with current sellar region ...
Tópico(s): Nasal Surgery and Airway Studies
2023 - Taylor & Francis | British Journal of Neurosurgery
J. Manuel Revuelta-Barbero, Alejandra Rodas, Edoardo Porto, Jackson R. Vuncannon, Youssef M. Zohdy, Justin Maldonado, C. Arturo Solares, Oswaldo A. Henriquez, Gustavo Pradilla,
This study aimed to objectively compare maneuverability at the contralateral medial orbit when approached through the traditional endoscopic endonasal approach (EEA) and EEA with transeptal window (TW).
Tópico(s): Pituitary Gland Disorders and Treatments
2023 - Thieme Medical Publishers (Germany) | Journal of Neurological Surgery Part B Skull Base
Hanyao Sun, Edoardo Porto, David P. Bray, J. Manuel Revuelta Barbero, John M. DelGaudio, Emily Barrow, Oswaldo A. Henriquez, Tomas Garzon Muvdi, C. Arturo Solares, Gustavo Pradilla,
Background: Proficiency in endoscopic endonasal neurosurgery (EEN) requires a unique skill set and is associated with a steep learning curve. Endoscopic simulation models present an opportunity for trainees to evolve their surgical skills and anatomical knowledge in a risk-free environment. Up to date, four main categories of training modalities have been recorded: cadaveric, synthetic, animal and virtual reality (VR) models.
Tópico(s): Augmented Reality Applications
2023 - Thieme Medical Publishers (Germany) | Journal of Neurological Surgery Part B Skull Base