J. Theisen, John J. Nigro, Tom R. DeMeester, Jeffrey H. Peters, Otávio Leite Gastal, J. A. Hagen, Masoomeh Hashemi, Cedric G. Bremner,
The objective of this study was to assess the course over time of the Barrett’s metaplasia–dysplasia–carcinoma sequence. The method used was a retrospective analysis of the medical records of a patient series with a median follow-up of 25 months. The study was undertaken in a university hospital foregut laboratory. The progress of seven patients was followed through the sequence of Barrett’s esophagus, low-grade dysplasia and high-grade dysplasia to cancer. They all underwent subsequent esophagectomy ...
Tópico(s): Head and Neck Cancer Studies
2004 - Oxford University Press | Diseases of the Esophagus
J. Theisen, Stefan Öberg, Jeffrey H. Peters, Otávio Leite Gastal, Cedric G. Bremner, Rodney J. Mason, Tom R. DeMeester,
It has been shown previously that patients with gastro-esophageal reflux disease (GERD) do not always have increased esophageal acid exposure on 24 h pH monitoring. The recent recognition of carditis as a sensitive marker for GERD raises the possibility for patients with mild disease to have normal esophageal acid exposure but inflamed cardiac mucosa on biopsies of the cardia, which may be an early sign of GERD. To test this hypothesis, 171 consecutive patients evaluated for symptoms of GERD and ...
Tópico(s): Eosinophilic Esophagitis
2001 - Oxford University Press | Diseases of the Esophagus
John J. Nigro, Steven R. DeMeester, Jeffrey A. Hagen, Tom R. DeMeester, Jeffrey H. Peters, Milton Kiyabu, Guilherme M. Campos, Stefan Öberg, Otávio Leite Gastal, Peter F. Crookes, Cedric G. Bremner,
Tópico(s): Esophageal and GI Pathology
1999 - Elsevier BV | Journal of Thoracic and Cardiovascular Surgery
Preoperative assessment can identify the predictors of esophageal shortening in patients with gastroesophageal reflux disease.Patient comparison study in a university-based tertiary care center.A total of 236 patients with gastroesophageal reflux disease underwent primary antireflux procedures. Sixty-five patients were suspected of having a short esophagus and underwent a transthoracic approach. In 37 patients, a lengthening procedure was necessary to avoid tension on the repair. The remaining 28 ...
Tópico(s): Esophageal Cancer Research and Treatment
1999 - American Medical Association | Archives of Surgery
Produção Nacional
Revisado por pares
Bruno Carlos Palombini, Carlos Antônio Castilhos Villanova, Elisabeth Araújo, Otávio Leite Gastal, Dayse Carneiro Alt, Daiana Prestes Stolz, Carlos Oliveira Palombini,
Background Coughing may be produced by a number of different disorders in distinct anatomic sites. Chronic cough causes major functional limitation in a considerable patient population and requires careful evaluation. Methods Seventy-eight nonsmoking patients of both genders who complained of cough for≥ 3 weeks and had normal findings on plain chest radiographs were studied prospectively. Their histories were obtained, and physical examinations were performed. The diagnostic workup included pulmonary ...
Tópico(s): Voice and Speech Disorders
1999 - Elsevier BV | CHEST Journal
Produção Nacional
Revisado por pares
Otávio Leite Gastal, June A. Castell, Donald O. Castell,
Prolonged ambulatory pH monitoring was performed on 89 patients with previous diagnosis of asthma (27 patients), chronic cough (28 patients), noncardiac chest pain (34 patients), and on 27 healthy control subjects. The extent of gastroesophageal reflux (GER) was determined using a catheter containing two antimony pH electrodes positioned 5 cm and 20 cm above the superior border of the manometrically determined lower esophageal sphincter. Reflux was defined as a drop in pH to <4 in the distal esophagus. ...
Tópico(s): Helicobacter pylori-related gastroenterology studies
1994 - Elsevier BV | CHEST Journal
Produção Nacional
Revisado por pares
Júlia Silveira Vianna, Ivy Bastos Ramis, Priscila Cristina Bartolomeu Halicki, Otávio Leite Gastal, Renato Azevedo da Silva, José Salomão, Deise Machado dos Santos, Ana Lucia Hentsch Chaves, Carlos Renan Varela Juliano, Heitor Alberto Jannke, Lande Vieira da Silva, Andréa von Groll, Pedro Eduardo Almeida da Silva,
CagA of Helicobacter pylori undergoes tyrosine phosphorylation in a region containing differing numbers of repeat sequences (EPIYAs), which can result in a modulation of the inflammatory response. This study investigated whether the presence of CagA EPIYA variations in strains of H. pylori that are positive for this region contributes to differing degrees of disease severity in the gastric mucosa. In this study, 157 H. pylori–positive patients were included, and of those, 40.8% (64/157) were infected ...
Tópico(s): Gastrointestinal disorders and treatments
2015 - Elsevier BV | Diagnostic Microbiology and Infectious Disease
Produção Nacional
Revisado por pares
Danielle Barbosa de Matos, Marcus Paulo Rosa Barbosa, Otávio Monteiro Leite, Juliana R. Steter, Nayara Silva Lima, Nádia Hortense Torres, Maria Nogueira Marques, Odélsia Leonor Sanchez de Alsina, Eliane Bezerra Cavalcanti,
After designing and constructing an electrochemical reactor with concentric electrodes and tangential feed (RECT), it is necessary to characterize it and to study its performance. The experimental study of the residence time distribution (RTD) was conducted for flow rates of 2.78 × 10-6 m3 s-1, 8.33 × 10-6 m3 s-1 and 13.9 × 10-6 m3 s-1. According to the values obtained from the Pe number (0.67-1.52), the RECT fits as tubular with great dispersion. The determined empirical correlation (Sh = 18.16 Re0.50 Sc0. ...
Tópico(s): Pesticide and Herbicide Environmental Studies
2018 - Taylor & Francis | Environmental Technology
Produção Nacional
Revisado por pares
Júlia Silveira Vianna, Ivy Bastos Ramis, Daniela Fernandes Ramos, Otávio Leite Gastal, Renato Azevedo da Silva, Carla Vitola Gonçalves, Pedro Eduardo Almeida da Silva,
In this study, we evaluated the mutations of Helicobacter pylori associated with resistance to clarithromycin and levofloxacin. Furthermore, based on the proposed interaction between antimicrobial resistance and pathogenicity, we correlated the mutation profiles of the strains with the presence of the pathogenicity gene cagA. We analyzed 80 gastric biopsy specimens from H. pylori-infected patients for point mutations in the 23S rRNA gene region and in the gyrA gene, which are related to clarithromycin ...
Tópico(s): Gastric Cancer Management and Outcomes
2018 - UNIVERSIDADE DE SÃO PAULO | Revista do Instituto de Medicina Tropical de São Paulo
Produção Nacional
Revisado por pares
Joel Alonso Palomino-Romero, Otávio Monteiro Leite, Katlin I.B. Eguiluz, Giancarlo R. Salazar‐Banda, Daniel Pereira Silva, Eliane Bezerra Cavalcanti,
PRODUCTION.The wastewaters from biodiesel production contain as primarily wastes sodium or potassium soaps, fatty acids, glycerin, alcohol and other contaminants.In general, these waters are chemically unsuitable for release to any water body, so, it is necessary the adoption of techniques for the treatment of this effluent.In this review, electrochemical, biological, physicochemical, and combined treatments reported for the removal of the wastewater containing pollutants come from biodiesel production ...
Tópico(s): Advanced oxidation water treatment
2012 - Brazilian Chemical Society | Química Nova
Produção Nacional
Revisado por pares
Sérgio Schalka, Denise Steiner, Flávia Naranjo Ravelli, Tatiana Aline Steiner, Aripuanã Cobério Terena, Carolina Reato Marçon, Eloísa Leis Ayres, Flávia Alvim Sant’Anna Addor, Hélio Amante Miot, Humberto Antonio Salomon Ponzio, Ida Duarte, Jane Marcy Neffá, José Antônio Jabur da Cunha, Juliana Catucci Boza, Luciana de Paula Samorano, Marcelo de Paula Corrêa, Marcus Maia, Nilton Nasser, Olga Maria Rodrigues Ribeiro Leite, Otávio Sérgio Lopes, Pedro Dantas Oliveira, Renata Leal Bregunci Meyer, Tânia Ferreira Cestari, Vitor Manoel Silva dos Reis, Vitória Regina Pedreira de Almeida Rêgo,
Brazil is a country of continental dimensions with a large heterogeneity of climates and massive mixing of the population. Almost the entire national territory is located between the Equator and the Tropic of Capricorn, and the Earth axial tilt to the south certainly makes Brazil one of the countries of the world with greater extent of land in proximity to the sun. The Brazilian coastline, where most of its population lives, is more than 8,500 km long. Due to geographic characteristics and cultural ...
Tópico(s): Skin Protection and Aging
2014 - Elsevier BV | Anais Brasileiros de Dermatologia
Produção Nacional
Revisado por pares
Carlos Andres Ferrero, Lucas May Petry, Luís Otávio Álvares, Camila Leite da Silva, Willian Zalewski, Vânia Bogorny,
Tópico(s): Time Series Analysis and Forecasting
2020 - Springer Science+Business Media | Data Mining and Knowledge Discovery
Produção Nacional
Revisado por pares
Ramires Alsamir Tibana, Leonardo M. de Almeida, Nuno Manuel Frade de Sousa, Dahan da Cunha Nascimento, Ivo Vieira de Sousa Neto, Jeeser Alves de Almeida, Vinícius Carius de Souza, Maria de Fátima T. P. L. Lopes, Otávio Tolêdo Nóbrega, Denis César Leite Vieira, James W. Navalta, Jonato Prestes,
The aim of this study was to investigate the effects of two consecutive Crossfit® training sessions (24 hours apart) designed to enhance work-capacity that involved both cardiovascular and muscular exercises on cytokines, muscle power, blood lactate and glucose. Nine male members of the CrossFit® community (age 26.7 ± 6.6 years; body mass 78.8 ± 13.2 kg; body fat 13.5 ± 6.2 %; training experience 2.5 ± 1.2 years) completed two experimental protocols (24 hours apart): 1) strength and power exercises 2) gymnastic ...
Tópico(s): Occupational Health and Performance
2016 - Frontiers Media | Frontiers in Physiology
Produção Nacional
Revisado por pares
Carina de Souza Gondim, Otávio Augusto Mazzoni Coelho, Ronália Leite Alvarenga, Roberto Gonçalves Junqueira, Scheilla Vitorino Carvalho de Souza,
The lack of well-established references for the validation of qualitative analyses and the increasing demand for reliable binary responses were the main motivating factors for this study. A detailed procedure for single-laboratory validation of qualitative methods is proposed. The experimental design and the tools for data analysis were based on the theoretical background, as well as the aspects of efficiency, convenience and simplicity. Four experimental steps were defined, as follows: (i) preliminary ...
Tópico(s): Pharmaceutical and Antibiotic Environmental Impacts
2014 - Elsevier BV | Analytica Chimica Acta
Produção Nacional
Revisado por pares
Chandra Chiappin Cardoso, Camila Matiollo, Carolina Hilgert Jacobsen Pereira, Janaína Sant'Ana Fonseca, Helder Emmanuel Leite Alves, Otávio Marcos da Silva, Vivian de Souza Menegassi, Cláudia Regina dos Santos, Ana Carolina Rabello de Moraes, Leonardo de Lucca Schiavon, Maria Cláudia Santos‐Silva,
Liver cirrhosis is often complicated by an immunological imbalance known as cirrhosis-associated immune dysfunction. This study aimed to investigate disturbances in circulating monocytes and dendritic cells in patients with acute decompensation (AD) of cirrhosis. The sample included 39 adult cirrhotic patients hospitalized for AD, 29 patients with stable cirrhosis (SC), and 30 healthy controls (CTR). Flow cytometry was used to analyze monocyte and dendritic cell subsets in whole blood and quantify ...
Tópico(s): Hepatitis Viruses Studies and Epidemiology
2021 - Nature Portfolio | Scientific Reports
Produção Nacional
Revisado por pares
Julio César Álvarez Iglesias, Karen Soares Augusto, Otávio da Fonseca Martins Gomes, Alei Leite Alcântara Domingues, Maria Beatriz Vieira, Catia Casagrande, Sidnei Paciornik,
This paper presents an automatic system for mineralogical and textural characterization of iron ores based on digital microscopy and image analysis. It employs a motorized and computer-controlled reflected light microscope in a correlative approach that combines bright field and circular polarization modes. Mosaic images covering large areas of polished sections are acquired to image thousands of particles. Different classifiers discriminate compact and non-compact hematite, polycrystalline and ...
Tópico(s): Image and Object Detection Techniques
2018 - Elsevier BV | Journal of Materials Research and Technology
Produção Nacional
Revisado por pares
Antonieta Middea, Luciana S. Spinelli, Fernando Gomes de Souza, Reiner Neumann, Thais L.A.P. Fernandes, Fabiano Richard Leite Faulstich, Otávio da Fonseca Martins Gomes,
ABSTRACT Water contaminated by oil poses challenges to the management of water resources. Magnetic nanoparticles has been issue of different potential applications including remotion oil from water. Magnetic polystyrene–palygorskite nanocomposites were prepared by a heterogeneous phase polymerization for the removal of organic contaminants from water. The organo‐Fe 3 O 4 ‐palygorskite nanoparticles were coated with polystyrene, forming water repellent and oil absorbing surfaces to promote the removal ...
Tópico(s): Iron oxide chemistry and applications
2017 - Wiley | Journal of Applied Polymer Science
Produção Nacional
Revisado por pares
Alexandre Sampaio Moura, Ricardo Andrade Carmo, Antônio Lúcio Teixeira, Virgínia Hora Rios Leite, Manoel Otávio da Costa Rocha,
Host immune response seems to be mainly responsible for the progression of liver disease among patients with hepatitis C virus (HCV) infection. Immune activation involves the release of cytokines and their receptors that can be measured in plasma samples. The study aimed to evaluate the association between plasma levels of chemokines and soluble tumor necrosis factor receptors (sTNFR) and liver histological changes among patients with chronic HCV infection. Seventy-one treatment-naive patients were ...
Tópico(s): Liver Disease Diagnosis and Treatment
2010 - Springer Science+Business Media | European Journal of Clinical Microbiology & Infectious Diseases
Produção Nacional
Revisado por pares
André L.A. Oliveira, Hitoshi Hayakawa, Doris Schor, Ana Claúdia Celestino Bezerra Leite, Otávio de Melo Espíndola, Allison Waters, Jonathan Dean, Derek G. Doherty, Abelardo Araújo, William W. Hall,
Abstract Human T lymphotropic virus type 2 (HTLV-2) is characterized by a clinically asymptomatic persistent infection in the vast majority of infected individuals. In this study, we have characterized for the first time ex vivo specific CTL responses against the HTLV-2 Tax protein. We could detect CTL responses only against a single HLA-A*0201-restricted Tax2 epitope, comprising residues 11–19 (LLYGYPVYV), among three alleles screened. Virus-specific CTLs could be detected in most evaluated subjects, ...
Tópico(s): Immune Cell Function and Interaction
2009 - American Association of Immunologists | The Journal of Immunology
Produção Nacional
Revisado por pares
Armênio Costa Guimarães, Marcus Vinícius Bolívar Malachias, Otávio Rizzi Coelho, E Zilli, Rafael Leite Luna,
Tópico(s): Hormonal and reproductive studies
1999 - Sociedade Brasileira de Cardiologia (SBC) | Arquivos Brasileiros de Cardiologia
Produção Nacional
Revisado por pares
Caroline Madeira, Mychael V. Lourenco, Charles Vargas-Lopes, Cláudia Kimie Suemoto, Carlos Otávio Brandão, Taylor Reis, Renata Elaine Paraízo Leite, Jerson Laks, Wilson Jacob Filho, Carlos Augusto Pasqualucci, Lea T. Grinberg, Sérgio T. Ferreira, Rogério Panizzutti,
Alzheimer's disease (AD) is a severe neurodegenerative disorder still in search of effective methods of diagnosis. Altered levels of the NMDA receptor co-agonist, d-serine, have been associated with neurological disorders, including schizophrenia and epilepsy. However, whether d-serine levels are deregulated in AD remains elusive. Here, we first measured D-serine levels in post-mortem hippocampal and cortical samples from nondemented subjects (n=8) and AD patients (n=14). We next determined d-serine ...
Tópico(s): Tryptophan and brain disorders
2015 - Springer Nature | Translational Psychiatry
Produção Nacional
Revisado por pares
Marco Antônio Lima, Marcus Tulius T. Silva, Cristiane Soares, Renan Coutinho, Henrique Soares Dutra Oliveira, Lívia Afonso, Otávio de Melo Espíndola, Ana Claúdia Celestino Bezerra Leite, Abelardo Araújo,
COVID-19 pandemic revealed several neurological syndromes related to this infection. We describe the clinical, laboratory, and radiological features of eight patients with COVID-19 who developed peripheral facial palsy during infection. In three patients, facial palsy was the first symptom. Nerve damage resulted in mild dysfunction in five patients and moderate in three. SARS-Cov-2 was not detected in CSF by PCR in any of the samples. Seven out of eight patients were treated with steroids and all ...
Tópico(s): Vestibular and auditory disorders
2020 - Springer Science+Business Media | Journal of NeuroVirology
Produção Nacional
Revisado por pares
Marco Antônio Lima, Marcus Tulius T. Silva, Raquel de Vasconcellos Carvalhães de Oliveira, Cristiane Soares, Crissi L. Takano, Anna E. Azevedo, Raissa L. Moraes, Rafaela B. Rezende, Ingrid T. Chagas, Otávio de Melo Espíndola, Ana Claúdia Celestino Bezerra Leite, Abelardo Araújo,
Tópico(s): Biochemical Analysis and Sensing Techniques
2020 - Elsevier BV | Journal of the Neurological Sciences
Produção Nacional
Revisado por pares
Clarissa R. Nascimento, Marco Antônio Lima, Maria José de Andrada Serpa, Otávio de Melo Espíndola, Ana Claúdia Celestino Bezerra Leite, Juliana Echevarria‐Lima,
Abstract Human T-cell lymphotropic virus type 1 (HTLV-1) is a causative agent of adult T-cell leukemia and HTLV-1–associated myelopathy/tropical spastic paraparesis. HTLV-1–associated myelopathy/tropical spastic paraparesis is a chronic inflammatory disease characterized by loss of motor movement in response to spinal marrow cell destruction by T lymphocytes. To perform their cellular function, T cells need to be activated by antigen-presenting cells, such as dendritic cells (DCs). The aim of this ...
Tópico(s): Vector-Borne Animal Diseases
2010 - Elsevier BV | Blood
Produção Nacional
Vanessa van der Linden, Epitácio Leite Rolim Filho, Otávio Gomes Lins, Ana van der Linden, Máría de Fátima Viana Vasco Aragão, Alessandra Mertens Brainer-Lima, Danielle Di Cavalcanti Sousa Cruz, Maria Ângela Wanderley Rocha, Paula Fabiana Sobral da Silva, Maria Durce Costa Gomes Carvalho, Fernando José do Amaral, Joelma Arruda Gomes, Igor Colaço Ribeiro de Medeiros, Camila V. Ventura, Regina Coeli Ferreira Ramos,
To describe the clinical, radiological, and electromyographic features in a series of children with joint contractures (arthrogryposis) associated with congenital infection presumably caused by Zika virus.Retrospective case series study.Association for Assistance of Disabled Children, Pernambuco state, Brazil.Seven children with arthrogryposis and a diagnosis of congenital infection presumably caused by Zika virus during the Brazilian microcephaly epidemic.Main clinical, radiological, and electromyographic ...
Tópico(s): Cerebral Palsy and Movement Disorders
2016 - | BMJ
Produção Nacional
Revisado por pares
Otávio de Melo Espíndola, Marilda Mendonça Siqueira, Cristiane Soares, Marco Antônio Lima, Ana Claúdia Celestino Bezerra Leite, Abelardo Araújo, Carlos Otávio Brandão, Marcus Tulius T. Silva,
We report that patients with COVID-19 displaying distinct neurological disorders have undetectable or extremely low levels of SARS-CoV-2 RNA in the cerebrospinal fluid, indicating that viral clearance precede the neurological involvement. This finding points to the need for the development of more sensitive molecular tests and the investigation of other neurotropic pathogens to exclude concurrent neuroinfection.
Tópico(s): Multiple Sclerosis Research Studies
2020 - Elsevier BV | International Journal of Infectious Diseases
Produção Nacional
Revisado por pares
José Mendes Ribeiro, Lenaura de Vasconcelos Costa Lobato, Jeni Vaitsman, Luís Otávio Farias, Maurício Teixeira Leite de Vasconcellos, Eliane Hollanda, Carla Pacheco Teixeira,
This study analyzes the mechanisms used in Brazil by health plan and insurance operators, hospitals and physicians for organizing the access to health care services and their strategies towards cost reduction and decision-making. The study is based on the literature about regulation of the health services, with special focus on micro-management and managed care. From an intentional sample of health care organizations selected according to the number of beneficiaries, organizational modality and ...
Tópico(s): Public Health in Brazil
2008 - ASSOCIAÇÃO BRASILEIRA DE SAÚDE COLETIVA | Ciência & Saúde Coletiva
Produção Nacional
Revisado por pares
Otávio T. Ranzani, Matt D. T. Hitchings, Rosana Leite de Melo, Giovanny Vinícius Araújo de França, Cássia de Fátima Rangel Fernandes, Margaret L. Lind, Mario Torres, Daniel Henrique Tsuha, Leticia C. S. David, Rodrigo Said, María Almirón, Roberto Dias de Oliveira, Derek A. T. Cummings, Natalie E. Dean, Jason R. Andrews, Albert I. Ko, Júlio Croda,
Abstract The effectiveness of inactivated vaccines (VE) against symptomatic and severe COVID-19 caused by omicron is unknown. We conducted a nationwide, test-negative, case-control study to estimate VE for homologous and heterologous (BNT162b2) booster doses in adults who received two doses of CoronaVac in Brazil in the Omicron context. Analyzing 1,386,544 matched-pairs, VE against symptomatic disease was 8.6% (95% CI, 5.6–11.5) and 56.8% (95% CI, 56.3–57.3) in the period 8–59 days after receiving a ...
Tópico(s): Vaccine Coverage and Hesitancy
2022 - Nature Portfolio | Nature Communications
Produção Nacional
Revisado por pares
Luís Otávio Sales Ferreira Caboclo, Eliana Garzón, Pedro Alessandro Leite de Oliveira, Henrique Carrete, Ricardo Silva Centeno, Marino Muxfeldt Bianchin, Elza Márcia Targas Yacubian, Américo Ceiki Sakamoto,
Summary Objective The objective of this retrospective study is to analyze ictal patterns observed during continuous Video-EEG monitoring in patients with temporal lobe epilepsy (TLE) due to unilateral hippocampal sclerosis (HS), and to correlate these EEG patterns to temporal pole abnormalities observed on magnetic resonance imaging exams. Methods We analyzed 147 seizures from 35 patients with TLE and unilateral HS. Ictal patterns were classified and correlated to signal abnormalities and volumetric measures ...
Tópico(s): EEG and Brain-Computer Interfaces
2006 - Elsevier BV | Seizure
Produção Nacional
Revisado por pares
Uirá Kulesza, Sérgio Soares, Christina Chávez, Fernando Castor, Paulo Borba, Carlos Lucena, Paulo César Masiero, Cláudio Sant’Anna, Fabiano Cutigi Ferrari, Vander Alves, Roberta Coelho, Eduardo Figueiredo, Paulo F. Pires, Flávia C. Delicato, Eduardo Kessler Piveta, Carla Silva, Valter Vieira de Camargo, Rosana Teresinha Vaccare Braga, Julio César Sampaio do Prado Leite, Otávio Augusto Lazzarini Lemos, Nabor C. Mendonça, Thaı́s Batista, Rodrigo Bonifácio, Nélio Cacho, Lyrene Fernandes da Silva, Arndt von Staa, Fábio Fagundes Silveira, Marco Túlio Valente, Fernanda Alencar, Jaelson Castro, Ricardo Ramos, Rosângela A. D. Penteado, Cecília M. F. Rubira,
Aspect-Oriented Software Development (AOSD) is a paradigm that promotes advanced separation of concerns and modularity throughout the software development lifecycle, with a distinctive emphasis on modular structures that cut across traditional abstraction boundaries. In the last 15 years, research on AOSD has boosted around the world. The AOSD-BR research community (AOSD-BR stands for AOSD in Brazil) emerged in the last decade, and has provided different contributions in a variety of topics. However, ...
Tópico(s): Software Engineering Techniques and Practices
2012 - Elsevier BV | Journal of Systems and Software