Hirenkumar Nakawala, Elena De Momi, Antonia Tzemanaki, Sanja Dogramadzi, Andrea Russo, Michele Catellani, Roberto Bianchi, Ottavio De Cobelli, Aristotelis Sideridis, Emmanuel Papacostas, Anthony Koupparis, Edward Rowe, Raj Persad, Raimondo Ascione, Giancarlo Ferrigno,
The robotic surgical systems and computer-assisted technologies market has seen impressive growth over the last decades, but uptake by end-users is still scarce. The purpose of this article is to provide a comprehensive and informed list of the end-user requirements for the development of new generation robot- and computer-assisted surgical systems and the methodology for eliciting them. The requirements were elicited, in the frame of the EU project SMARTsurg, by conducting interviews on use cases ...
Tópico(s): Soft Robotics and Applications
2019 - SAGE Publishing | International Journal of Advanced Robotic Systems
Barbara Alicja Jereczek‐Fossa, G. Beltramo, Laura Fariselli, Cristiana Fodor, Luigi Santoro, Andrea Vavassori, Dario Zerini, Federica Gherardi, Carmen Ascione, Isa Bossi-Zanetti, Roberta Di Mauro, Achille Bregantin, Livia Bianchi, Ottavio De Cobelli, Roberto Orecchia,
Purpose To evaluate the outcome of robotic CyberKnife (Accuray, Sunnyvale, CA)–based stereotactic radiotherapy (CBK-SRT) for isolated recurrent primary, lymph node, or metastatic prostate cancer. Methods and Materials Between May 2007 and December 2009, 34 consecutive patients/38 lesions were treated (15 patients reirradiated for local recurrence [P], 4 patients reirradiated for anastomosis recurrence [A], 16 patients treated for single lymph node recurrence [LN], and 3 patients treated for single metastasis [ ...
Tópico(s): Prostate Cancer Treatment and Research
2011 - Elsevier BV | International Journal of Radiation Oncology*Biology*Physics
Genevieve Ko, Summer Paradise, Hong Chen, Morven Graham, Manuela Vecchi, Fabrizio Bianchi, Ottavio Cremona, Pier Paolo Di Fiore, Pietro De Camilli,
Epsin is a ubiquitin-binding endocytic adaptor, which is highly concentrated at clathrin-coated pits and coordinates acquisition of bilayer curvature with coat recruitment and cargo selection. Epsin is encoded by three distinct genes in mammals. Epsin 1 and 2 have broad tissue distribution with high-level expression in the brain. In contrast, epsin 3 was reported to be expressed primarily in immature keratinocytes. Here, we show that epsin 3 is selectively expressed at high levels in the stomach ( ...
Tópico(s): Ubiquitin and proteasome pathways
2010 - National Academy of Sciences | Proceedings of the National Academy of Sciences
L Parenzan, Giancarlo Crupi, Ottavio Alfieri, T Bianchi, V. Vanini, Giuseppe Locatelli, R Tiraboschi, Giuseppe Di Benedetto, M Villani, Francesco Paolo Annecchino, Paolo Ferrazzi,
Fourteen patients younger than two years of age with persistent truncus arteriosus underwent primary repair. Twelve of them were less than 1 year and 4 less than 3 months of age. Intractable heart failure was the indication for surgery in all patients but one who had increased pulmonary vascular resistance. There were 5 hospital and 2 late deaths. Six out of the 7 survivors (median follow-up: 29 months) were symptom-free. The remaining infant who preoperatively had significant truncal valve regurgitation ...
Tópico(s): Congenital Diaphragmatic Hernia Studies
1980 - Georg Thieme Verlag | The Thoracic and Cardiovascular Surgeon
Martino Pepe, Alessandro Cafaro, Valeria Paradies, Nicola Signore, Francesco Addabbo, Alessandro Santo Bortone, Eliano Pio Navarese, Gaetano Contegiacomo, Cinzia Forleo, Francesco Bartolomucci, Ottavio Di Cillo, Francesco Paolo Bianchi, Domenico Zanna, Stefano Favale,
Abstract Objectives The aim of this observational study was to determine the benefits of the novel, orally delivered P2Y 12 ‐inhibitors (Is) in terms of angiographic endpoints and in relation to the time of the loading dose (LD) administration. Background The goal of ST‐elevation myocardial infarction (STEMI) treatment is timely reperfusion. The P2Y 12 ‐Is prasugrel and ticagrelor have improved the angiographic outcome of primary percutaneous coronary intervention (pPCI) and patients' prognosis. However, ...
Tópico(s): Acute Myocardial Infarction Research
2018 - Wiley | Catheterization and Cardiovascular Interventions
Giulio Alessandri Bonetti, Ottavio Piccin, Lorenzo Lancellotti, Alberto Bianchi, Claudio Marchetti,
Tópico(s): Cleft Lip and Palate Research
2008 - Springer Science+Business Media | Sleep And Breathing
Ottavio Alfieri, Giuseppe Locatelli, Tiziano Bianchi, Vittorio Vanini, L Parenzan,
Sixty-three corrective operations have been performed in patients with Tetralogy of Fallot and a previously constructed Waterston shunt. The patients were from 1.4 to 8 years of age (median 4.3 years), and the mean interval between the Waterston shunt and the repair was 39.3 +/- 16.05 months. Three patients developed pulmonary atresia and six required a second anastomosis prior to intracardiac repair. Kinking and stenosis of the right pulmonary artery at the site of the Waterston anastomosis occurred ...
Tópico(s): Congenital Diaphragmatic Hernia Studies
1979 - Elsevier BV | Journal of Thoracic and Cardiovascular Surgery
... These included proto-fascists such as Sergio Panunzio, Ottavio Dinale, Agostino Lanzillo, Angelo Oliviero Olivetti, Michele Bianchi and Edmondo Rossoni, and fascists such as Mussolini' ...
Tópico(s): Economic Theory and Institutions
2006 - Taylor & Francis | New Political Economy
L Parenzan, Ottavio Alfieri, Vittorio Vanini, Tiziano Bianchi, Massimo Villani, R Tiraboschi, Giancarlo Crupi, Giuseppe Locatelli,
Two hundred twenty-seven patients (median age 5.4 months) in whom a Waterston anastomosis was done for initial palliation of tetralogy of Fallot between 1966 and 1979 were studied. Twelve patients died in the hospital (5.3%; 70% confidence limits, 3.8% to 7.3%). Young age, low weight, and poor clinical condition did not appear to be incremental risk factors, whereas a too large or a too small shunt was largely responsible for the hospital mortality and morbidity. Follow-up information was available ...
Tópico(s): Congenital Diaphragmatic Hernia Studies
1981 - Elsevier BV | Journal of Thoracic and Cardiovascular Surgery
Sarah Alessi, Paola Pricolo, Paul Summers, Marco Femia, Elena Tagliabue, Giuseppe Renne, Roberto Bianchi, Gennaro Musi, Ottavio De Cobelli, Barbara Alicja Jereczek‐Fossa, Massimo Bellomi, Giuseppe Petralia,
To evaluate whether low PI-RADS v2 assessment categories are effective at excluding extraprostatic extension (EPE) of prostate cancer (≥pT3a PCa). The local institutional ethics committee approved this retrospective analysis of 301 consecutive PCa patients. Patients were classified as low- or intermediate/high-risk based on clinical parameters and underwent pre-surgical multiparametric magnetic resonance imaging. A PI-RADS v2 assessment category and ESUR EPE score were assigned for each lesion by two ...
Tópico(s): Urologic and reproductive health conditions
2019 - Springer Science+Business Media | European Radiology
A. Petrone, Fortunato Battaglia, Cheng Wang, Adina Dusa, Jing Su, David Zagzag, Riccardo Bianchi, Patrizia Casaccia‐Bonnefil, Ottavio Arancio, Jan Sap,
... more papers by this author Riccardo Bianchi Riccardo Bianchi Department of Physiology and Pharmacology, SUNY Downstate Medical Center, Brooklyn, NY, 11203 USA Search for more papers by this author Patrizia Casaccia-Bonnefil Patrizia Casaccia-Bonnefil Department of Neuroscience and Cell Biology, UMDNJ, Piscataway, NJ, 08854 USA Search for more papers by this author Ottavio Arancio Ottavio Arancio Nathan Kline Institute for Psychiatric ... more papers by this author Riccardo Bianchi Riccardo Bianchi Department of Physiology and Pharmacology, SUNY Downstate Medical Center, Brooklyn, NY, 11203 USA Search for more papers by this author Patrizia Casaccia-Bonnefil Patrizia Casaccia-Bonnefil Department of Neuroscience and Cell Biology, UMDNJ, Piscataway, NJ, 08854 USA Search for more papers by this author Ottavio Arancio Ottavio Arancio Nathan Kline Institute for Psychiatric ...
Tópico(s): MicroRNA in disease regulation
2003 - Springer Nature | The EMBO Journal
Rosanna Mezzapelle, Francesco De Marchis, Chiara Passera, M. Di Leo, Francesca Brambilla, Federica Colombo, Maura Casalgrandi, Alessandro Preti, Samuel Zambrano, Patrizia Castellani, Riccardo Ertassi, Marco Silingardi, Francesca Caprioglio, Veronica Basso, Renzo Boldorini, Angelo Carretta, Francesca Sanvito, Ottavio Rena, Anna Rubartelli, Lina Sabatino, Anna Mondino, Massimo P. Crippa, Vittorio Colantuoni, Marco E. Bianchi,
... Basso7, Renzo Boldorini8,9, Angelo Carretta10, Francesca Sanvito11, Ottavio Rena12, Anna Rubartelli6, Lina Sabatino3, Anna Mondino7, Massimo P Crippa1, Vittorio Colantuoni *,3 and Marco E Bianchi *,1,2 1Chromatin Dynamics Unit, Division of Genetics ...
Tópico(s): Immunotherapy and Immune Responses
2021 - Springer Nature | EMBO Molecular Medicine
Gabriele Cozzi, Gennaro Musi, Massimo Monturano, Vincenzo Bagnardi, Samuele Frassoni, Barbara Alicja Jereczek‐Fossa, Matteo Ferro, Roberto Bianchi, Francesco Alessandro Mistretta, Ottavio De Cobelli,
Aims of this study were to assess sexual recovery after robotic-assisted radical prostatectomy (RARP) and to build a nomogram predicting 1-year sexual function. From May 2015 to July 2016, all patients eligible for RARP at our institution were invited to enter the study. The Expanded Prostate cancer Index Composite (EPIC) questionnaire was administered pre-operatively, then at 45 days, and at 3, 6, 9, and 12 months post-operatively. According to sexual function scores, patients were divided into four ...
Tópico(s): Sexual function and dysfunction studies
2019 - Wiley | Andrologia
Hirenkumar Nakawala, Roberto Bianchi, Laura Erica Pescatori, Ottavio De Cobelli, Giancarlo Ferrigno, Elena De Momi,
Tópico(s): Anatomy and Medical Technology
2018 - Springer Science+Business Media | International Journal of Computer Assisted Radiology and Surgery
Robert Schueler, Marek Kowalski, Jörg Hausleiter, Joachim Schöfer, Volker Rudolph, Maurizio Taramasso, Francesco Maisano, Neil Fam, Giovanni Bianchi, Francesco Bedogni, Ottavio Alfieri, Azeem Latib, Antonio Colombo, Christoph Hammerstingl, Georg Nickenig,
from reoperation at 10 years was similar between two groups (66.7±27.2% vs. 50±35%, p=0.610)When compared to general population (sex and age-matched) patients of both groups as a significant lower long-term survival.Conclusion: TVS appears to confer satisfactory short and long-term results despite its surgical complexity and higher risk.The choice of the mitral procedure did not significantly affected survival and major adverse events at 10 years after surgery in our population.
Tópico(s): Cardiac Arrhythmias and Treatments
2017 - Oxford University Press | European Heart Journal
Andrea Vavassori, Barbara Alicja Jereczek‐Fossa, G. Beltramo, Luigi De Cicco, Laura Fariselli, Livia Bianchi, M. Possanzini, A. Bergantin, Ottavio De Cobelli, Roberto Orecchia,
Technological advances in treatment planning and execution are providing new potential opportunities in the treatment of recurrent prostate cancer. This study was conducted to evaluate the feasibility and safety of reirradiation with image-guided radiosurgery using CyberKnife, a robotic arm-driven compact linear accelerator, for intraprostatic recurrence after external beam radiotherapy (EBRT).Between September 2007 and May 2008, 6 patients diagnosed with locally recurrent prostate cancer after EBRT ...
Tópico(s): Advanced Radiotherapy Techniques
2010 - SAGE Publishing | Tumori Journal
Georg Nickenig, Marek Kowalski, Jörg Hausleiter, Daniel Braun, Joachim Schöfer, Ermela Yzeiraj, Volker Rudolph, Kai Friedrichs, Francesco Maisano, Maurizio Taramasso, Neil Fam, Giovanni Bianchi, Francesco Bedogni, Paolo Denti, Ottavio Alfieri, Azeem Latib, Antonio Colombo, Christoph Hammerstingl, Robert Schueler,
Background: Current surgical and medical treatment options for severe tricuspid regurgitation (TR) are limited, and additional interventional approaches are required. In the present observational study, the safety and feasibility of transcatheter repair of chronic severe TR with the MitraClip system were evaluated. In addition, the effects on clinical symptoms were assessed. Methods: Patients with heart failure symptoms and severe TR on optimal medical treatment were treated with the MitraClip system. ...
Tópico(s): Cardiac Arrhythmias and Treatments
2017 - Lippincott Williams & Wilkins | Circulation
Rita Pavasini, Gioele Fabbri, Luca Di Ienno, Maria Angela Deserio, Federico Sanguettoli, Nicola Bianchi, Ottavio Zucchetti, Emanuele D’Aniello, Alberto Papi, Savino Spadaro, Marco Contoli, Gianluca Campo,
To the Editor One of the most common complications of Coronavirus Disease 19 (COVID-19) is the development of supraventricular arrhythmias (SA).1–4 COVID-19 patients developing SA are at higher risk of worse prognosis, because of the development of hemodynamic instability, of the difficult management of the rhythm and rate control and of the related treatments (i.e. anticoagulants drugs) further causing adverse events (i.e. bleedings).3 The aim of this study was to detect clinical, and echocardiographic ...
Tópico(s): COVID-19 Clinical Research Studies
2022 - Lippincott Williams & Wilkins | Journal of Cardiovascular Medicine
Laura Curti, Sara Rohban, Nicola Bianchi, Ottavio Croci, Adrian Andronache, Sara Barozzi, Michela Mattioli, Fernanda Ricci, Elena Pastori, Silvia Sberna, Simone Bellotti, Anna Accialini, Roberto Ballarino, Nicola Crosetto, Mark Wade, Dario Parazzoli, Stefano Campaner,
The identification of genes involved in replicative stress is key to understanding cancer evolution and to identify therapeutic targets. Here, we show that CDK12 prevents transcription-replication conflicts (TRCs) and the activation of cytotoxic replicative stress upon deregulation of the MYC oncogene. CDK12 was recruited at damaged genes by PARP-dependent DDR-signaling and elongation-competent RNAPII, to repress transcription. Either loss or chemical inhibition of CDK12 led to DDR-resistant transcription ...
Tópico(s): Genomics and Chromatin Dynamics
2024 - Nature Portfolio | Nature Communications
Barbara Alicja Jereczek‐Fossa, Laura Fariselli, G. Beltramo, Gianpiero Catalano, Flavia Serafini, Cristina Garibaldi, Raffaella Cambria, Lorenzo Brait, M. Possanzini, Livia Bianchi, Andrea Vavassori, Dario Zerini, Franco Orsi, Ottavio De Cobelli, Roberto Orecchia,
We report on 14 patients treated with linac- or robotic image-guided stereotactic radiotherapy for isolated lymph node recurrence from prostate cancer, up to the mean dose of 30Gy/3 fractions. At the mean follow-up of 18.6months, five patients experienced clinical out-field progression. Toxicity was minimal. Further investigation is warranted in order to identify the patients that benefit most from this treatment modality and to define the optimal association of such local approach with androgen ...
Tópico(s): Prostate Cancer Treatment and Research
2009 - Elsevier BV | Radiotherapy and Oncology
Stefano Luzzago, Ottavio De Cobelli, Francesco Alessandro Mistretta, Mattia Luca Piccinelli, Vito Lorusso, Michele Morelli, Roberto Bianchi, Michele Catellani, Gabriele Cozzi, Ettore Di Trapani, Paola Pricolo, Sarah Alessi, Matteo Ferro, Giulia Marvaso, D.V. Matei, Barbara Alicja Jereczek‐Fossa, Giuseppe Petralia, Gennaro Musi,
Tópico(s): Prostate Cancer Treatment and Research
2020 - Springer Nature | Prostate Cancer and Prostatic Diseases
Gabriele Cozzi, Gennaro Musi, Martina Milani, Costantino Jemos, Sara Gandini, Ludovica Mazzoleni, Matteo Ferro, Stefano Luzzago, Roberto Bianchi, Emanuela Omodeo Salè, Ottavio De Cobelli,
Introduction: Radical cystectomy (RC) is the gold standard treatment for patients with muscle-invasive or refractory non-muscle invasive bladder cancer. It is estimated that approximately 64% and 13% of RC patients experience any complication and major complications, respectively. Specialized immunonutrition (SIM) aims to reduce the rates of complications after RC. We reported surgical complication rates in RC patients who received (SIM group) versus who did not receive (no-SIM group) perioperative ...
Tópico(s): Urological Disorders and Treatments
2021 - SAGE Publishing | Integrative Cancer Therapies
Elena Bignami, Nunzia Casamassima, Elena Frati, Chiara Lanzani, Laura Corno, Ottavio Alfieri, Stephen S. Gottlieb, Marco Simonini, Keyur B. Shah, Anna Mizzi, Elisabetta Messaggio, Alberto Zangrillo, Mara Ferrandi, Paolo Ferrari, Giuseppe Bianchi, John M. Hamlyn, Paolo Manunta,
Acute kidney injury is a frequent complication of cardiac surgery and increases morbidity and mortality. As preoperative biomarkers predicting the development of acute kidney injury are not available, we have tested the hypothesis that preoperative plasma levels of endogenous ouabain may function as this type of biomarker.Endogenous ouabain is an adrenal stress hormone associated with adverse cardiovascular outcomes. Its involvement in acute kidney injury is unknown. With studies in patients and ...
Tópico(s): Hemodynamic Monitoring and Therapy
2013 - Lippincott Williams & Wilkins | Critical Care Medicine
Francesco A Mistretta, Ottavio De Cobelli, Paolo Verze, Francesco Botticelli, Letizia Maria Ippolita Jannello, Stefano Luzzago, Gabriele Cozzi, Roberto Bianchi, Ettore Di Trapani, Matteo Ferro, Giovanni Cordima, Danilo Bottero, Deliu‐Victor Matei, Vincenzo Mirone, Gennaro Musi,
Sexual disorders following retroperitoneal pelvic lymph node dissection (RPLND) for testis tumor can affect the quality of life of patients. The aim of the current study was to investigate several different andrological outcomes, which may be influenced by robot-assisted (RA) RPLND. From January 2012 to March 2020, 32 patients underwent RA-RPLND for stage I nonseminomatous testis cancer or postchemotherapy (PC) residual mass. Modified unilateral RPLND nerve-sparing template was always used. Major variables ...
Tópico(s): Genital Health and Disease
2022 - Medknow | Asian Journal of Andrology
Mihai Dorin Vartolomei, D.V. Matei, Giuseppe Renne, Valeria Tringali, Mark A. Ferro, R. M. Bianchi, Anthony J. Russo, G. Cozzi, Ottavio De Cobelli,
Tópico(s): Testicular diseases and treatments
2017 - Elsevier BV | European Urology Supplements
Deliu Victor Matei, Mihai Dorin Vartolomei, Giuseppe Renne, Valeria Tringali, Andrea Russo, Roberto Bianchi, Gabriele Cozzi, Danilo Bottero, Gennaro Musi, Giovanni Mazzarol, Matteo Ferro, Ottavio De Cobelli,
Frozen section examination (FSE) for testicular masses is gaining popularity because of the possibility of performing testis-sparing surgery (TSS) on the basis of the FSE results. The aim of our study was to investigate the reliability of FSE in the diagnosis of testicular masses.From 1999 to 2016, 144 of 692 patients who underwent surgery in our tertiary center for testicular masses had FSE. The indications for FSE were: masses < 1 cm, nonpalpable, multiple, or with unusual presentation. Mean follow- ...
Tópico(s): Urologic and reproductive health conditions
2017 - Elsevier BV | Clinical Genitourinary Cancer
Stefano Luzzago, Francesco Mistretta, Giovanni Mauri, Chiara Vaccaro, Gaia Ghilardi, Daniele Maiettini, Andrea Marmiroli, Gianluca Maria Varano, Ettore Di Trapani, Nicola Camisassi, Roberto Bianchi, Paolo Della Vigna, Matteo Ferro, Guido Bonomo, Ottavio De Cobelli, Franco Orsi, Gennaro Musi,
To test TRIFECTA achievement [1) absence of CLAVIEN-DINDO ≥3 complications; 2) complete ablation; 3) absence of ≥30% decrease in eGFR] and local recurrence rates, according to tumor size, in patients treated with thermal ablation (TA: radiofrequency [RFA] and microwave ablation [MWA]) for small renal masses.Retrospective analysis (2008-2020) of 432 patients treated with TA (RFA: 162 vs. MWA: 270). Tumor size was evaluated as: 1) continuously coded variable (cm); 2) tumor size strata (0.1-2 vs. 2.1-3 vs. 3. ...
Tópico(s): Bladder and Urothelial Cancer Treatments
2022 - Elsevier BV | Urologic Oncology Seminars and Original Investigations
Francesco Bedogni, Luca Testa, Antonio Popolo Rubbio, Giovanni Bianchi, Carmelo Grasso, Salvatore Scandura, Federico De Marco, Maurizio Tusa, Paolo Denti, Ottavio Alfieri, Arturo Giordano, Paolo Ferraro, Antonio L. Bartorelli, Annalisa Mongiardo, Anna Sonia Petronio, Cristina Giannini, Francesco De Felice, Cesare Baldi, Fausto Castriota, Marianna Adamo, Giulia Masiero, Cosmo Godino, Matteo Montorfano, Giuseppe Tarantini, Corrado Tamburino,
Available scientific evidence of transcatheter mitral valve repair with the MitraClip comes from randomized controlled trials, which showed controversial results that hardly translate into real-world practice, and from registries of relatively small sample size. To collect real-world data in a multicenter, prospective, country-level registry. The Italian Society of Interventional Cardiology (GIse) Registry Of Transcatheter Treatment of Mitral Valve RegurgitaTiOn (GIOTTO) is an ongoing single-arm, ...
Tópico(s): Cardiac pacing and defibrillation studies
2020 - Elsevier BV | Cardiovascular revascularization medicine
Ottavio Alfieri, T Bianchi, Giuseppe Locatelli, V. Vanini, L Parenzan,
Intracardiac repair of a variety of cardiac anomalies was performed in 104 infants aged 10 days to 6 mo, presenting with severe hypoxia and/or intractable heart failure. Thirty-eight patients (33 less than three mo of age) did not survive the operation or died during the first postoperative month. Above 6 mo of age, correction of heart defects is often carried out on an elective basis, and results are more favorable. A more convenient choice between corrective and palliative procedures is suggested ...
Tópico(s): Hemodynamic Monitoring and Therapy
1977 - Elsevier BV | Journal of Pediatric Surgery
Matteo Ferro, Danilo Bottero, Carolina D’Elia, Deliu Victor Matei, Antonio Cioffi, Gabriele Cozzi, Alessandro Serino, Giovanni Cordima, Roberto Bianchi, Piero Incarbone, A. Brescia, Gennaro Musi, Ferdinando Fusco, Serena Detti, Vincenzo Mirone, Ottavio De Cobelli,
To evaluate the efficacy and safety of the Virtue® male sling (Coloplast, Humlebaek, Denmark) in a cohort of patients affected by post-prostatectomy stress urinary incontinence (SUI).All 29 consecutive patients treated with a Virtue male sling at our Institution between July 2012 and October 2013 were included in the present prospective, non-randomized study. Patients were evaluated preoperatively and at 1, 3, 6, 12, 24 and 36 months after surgery using a 24-h pad weight test, the International Consultation ...
Tópico(s): Urinary Bladder and Prostate Research
2016 - Wiley | BJU International