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Artigo Acesso aberto Revisado por pares

Britta Buchhold, Stine Lutze, Jennis Freyer‐Adam, Michael Jünger, Marleen Ramp, Wolfgang Konschake, Andreas Jülich, Claudia Nordt, Sebastian Peters, Andreas Arnold, Hans‐Joachim Hannich,

The basis for adequate psycho-oncological care is the identification of patients with psychosocial support needs. The German Working Group for Psychooncology also recommends the Hornheider Screening Instrument (HSI) for this purpose. The question, "Is anyone in your family particularly burdened by the hospital stay?" is intended to capture disease-related family stress. But is this item equally suitable for outpatients and inpatients? The study objective was to examine how replacing the original item ...

Tópico(s): Psoriasis: Treatment and Pathogenesis

2022 - Wiley | JDDG Journal der Deutschen Dermatologischen Gesellschaft

Artigo Acesso aberto Revisado por pares

Britta Buchhold, Stine Lutze, Jennis Freyer‐Adam, Michael Jünger, Marleen Ramp, Wolfgang Konschake, Andreas Jülich, Claudia Nordt, Sebastian Peters, Andreas Arnold, Hans‐Joachim Hannich,

Die Basis für adäquate psychoonkologische Betreuung ist die Identifikation von Patienten mit psychosozialem Unterstützungsbedarf. Die Deutsche Arbeitsgemeinschaft für Psychoonkologie empfiehlt hierfür das Hornheider Screening-Instrument (HSI). Die Frage: „Ist jemand in Ihrer Familie durch den Krankenhausaufenthalt besonders belastet?“ soll die krankheitsbedingte familiäre Belastung erfassen. Doch ist dieses Item für ambulante und stationäre Patienten gleichermaßen geeignet? Studienziel war zu überprüfen, ...

Tópico(s): Psoriasis: Treatment and Pathogenesis

2022 - Wiley | JDDG Journal der Deutschen Dermatologischen Gesellschaft

Artigo

Matthäus Metz, Marianna Beghini, Peter Wolf, Lorenz Pfleger, Martina Häckl, Magdalena Bastian, Angelika Freudenthaler, Jürgen Harreiter, Maximilian Zeyda, Sabina Baumgartner‐Parzer, Rodrig Marculescu, Nara Marella, Thomas Hannich, Georg Györi, Gabriela Berlakovic, Michael Roden, Michael Krebs, Michael Trauner, Alexandra Kautzky-Willers, Martin Krššák, Herbert Stangl, Clemens Fürnsinn, Thomas Scherer,

Recombinant human leptin (metreleptin) reduces hepatic lipid content in patients with lipodystrophy and overweight non-alcoholic fatty liver disease patients with relative hypoleptinemia independent of its anorexic action. In rodents, CNS leptin signaling increases very-low density lipoprotein triglyceride (VLDL-TG) secretion and reduces hepatic lipid content via the vagus nerve. In this randomized, placebo-controlled, crossover trial we tested whether a comparable mechanism regulates hepatic lipid ...

Tópico(s): Adipose Tissue and Metabolism

2022 - RELX Group (Netherlands) | SSRN Electronic Journal

Artigo Acesso aberto Revisado por pares

Sevgi Köstel Bal, Sarah Giuliani, Jana Block, Peter Repiščák, Christoph Hafemeister, Tala Shahin, Nurhan Kasap, Bernhard Ransmayr, Yirun Miao, Cheryl van de Wetering, Alexandra Frohne, Raúl Jiménez Heredia, Michael Schuster, Samaneh Zoghi, Vanessa Hertlein, Marini Thian, Aleksandr Bykov, Royala Babayeva, Sevgi Bilgiç Eltan, Elif Karakoç-Aydıner, Lisa E. Shaw, Iftekhar Chowdhury, Markku Varjosalo, Rafael J. Argüello, Matthias Farlik, Ahmet Özen, Edgar Serfling, Loı̈c Dupré, Christoph Bock, Florian Halbritter, J. Thomas Hannich, Irinka Castanon, Michael J. Kraakman, Safa Barış, Kaan Boztuğ,

The nuclear factor of activated T cells (NFAT) family of transcription factors plays central roles in adaptive immunity in murine models; however, their contribution to human immune homeostasis remains poorly defined. In a multigenerational pedigree, we identified 3 patients who carry germ line biallelic missense variants in NFATC1, presenting with recurrent infections, hypogammaglobulinemia, and decreased antibody responses. The compound heterozygous NFATC1 variants identified in these patients ...

Tópico(s): Biochemical and Molecular Research

2023 - Elsevier BV | Blood